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101. P.02.6 LOW FODMAP DIET IN THE LONG TERM: EFFICACY, ACCEPTABILITY AND INDIVIDUAL PERCEPTION OF TRIGGER FOODS. A PILOT STUDY

Author

Rossi, A., primary, Nagy, A.G., additional, Gambaccini, D., additional, Bertani, L., additional, Pancetti, A., additional, Zari, M., additional, Costa, F., additional, Bazzichi, L., additional, De Bortoli, N., additional, Morganti, R., additional, Mosca, M., additional, Marchi, S., additional, and Bellini, M., additional

Published
2019
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102. P.01.25 CAN A NON-INVASIVE TEST PREDICT THE RESULTS OF PH-IMPEDANCE? PROSPECTIVE STUDY OF A COHORT OF PATIENTS WITH EXTRA-ESOPHAGEAL MANIFESTATIONS OF GERD

Author

Cesario, S., primary, De Bortoli, N., additional, Savarino, E., additional, Singh, H., additional, Zari, M., additional, Di Chio, T., additional, Miraglia, C., additional, Franzoni, L., additional, Nouvenne, A., additional, Crafa, P., additional, Marchi, S., additional, and Di Mario, F., additional

Published
2019
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104. P.07.31 PREGNANCY AND INFANT FEEDING PATTERN IN IBD PATIENTS: A SINGLE CENTER EXPERIENCE

Author

Laino, G., primary, Di Fluri, G., additional, Mbeng, T.S.A., additional, Mumolo, M.G., additional, Ceccarelli, L., additional, Carmignani, A., additional, Tongiorgi, A., additional, De Bortoli, N., additional, Albano, E., additional, Tapete, G., additional, Bertani, L., additional, Svizzero, G. Baiano, additional, Marchi, S., additional, and Costa, F., additional

Published
2019
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107. P.01.2 ESOPHAGO-GASTRIC JUNCTION CONTRACTILE INTEGRAL (EGJ-CI) MAY PREDICT RESPONSE TO TREATMENT IN PATIENTS WITH ESOPHAGEAL ACHALASIA

Author

De Bortoli, N., primary, Di Chio, T., additional, Frazzoni, M., additional, Santi, S., additional, Sgherri, G., additional, Nasoni, S., additional, Frazzoni, L., additional, Fuccio, L., additional, Zari, M., additional, Albano, E., additional, Pallabazzer, G., additional, Bellini, M., additional, Peroni, D., additional, Marchi, S., additional, and Savarino, E., additional

Published
2019
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108. OC.11.1 UNRESPONSIVE DYSPHAGIA TO PROTON PUMP INHIBITORS IN EOSINOPHILIC ESOPHAGITIS PATIENTS SUGGESTS TO START STEROID THERAPY WITHOUT THE NEED OF PERFORMING A SECOND UPPER ENDOSCOPY

Author

Della Coletta, M., primary, Frazzoni, M., additional, Frazzoni, L., additional, Ghisa, M., additional, Tolone, S., additional, De Bortoli, N., additional, Gubbiotti, A., additional, Marabotto, E., additional, Furnari, M., additional, Savarino, V., additional, and Savarino, E.V., additional

Published
2019
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111. P416 Faecal calprotectin can predict mucosal healing in patients with inflammatory bowel diseases treated with vedolizumab: a prospective single-centre study

Author

Bertani, L, primary, Ceccarelli, L, additional, Mumolo, M G, additional, Tedeschi, R, additional, Albano, E, additional, Tapete, G, additional, Baiano Svizzero, G, additional, De Bortoli, N, additional, Ricchiuti, A, additional, Bellini, M, additional, Marchi, S, additional, and Costa, F, additional

Published
2019
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113. Overlap of GERD & gastrointestinal functional disorders

Author

S. Melissari, Natali, G. Tapete, N. Simonetti, Santino Marchi, and de Bortoli N

Subjects
medicine.medical_specialty, Gastrointestinal Diseases, Endocrinology, Diabetes and Metabolism, Population, Chest pain, Gastroenterology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Internal Medicine, medicine, Humans, Esophagus, Dyspepsia, education, Irritable bowel syndrome, education.field_of_study, business.industry, Reflux, Heartburn, medicine.disease, digestive system diseases, medicine.anatomical_structure, Gastroesophageal, 030220 oncology & carcinogenesis, GERD, Gastroesophageal Reflux, 030211 gastroenterology & hepatology, medicine.symptom, business
Abstract

The functional gastrointestinal disorders (FGIDs) are common conditions with an overall prevalence burden estimated at approximately one-third of the population. These represent a heterogeneous group of conditions which may include both abnormal symptom perception and functional causes and seems to share similar trigger factors as food, lifestyle and psychological factor. GERD develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms, with or without mucosal involvement. Functional heartburn (FH) represents a subcategory of patients who refers with heartburn but without abnormal esophageal acid exposure, abnormal number of reflux events or any temporal correlation between symptoms and reflux events, on the same hands these patients do not report any symptom relief during antisecretory treatment with proton pump inhibitors. To date, several studies have reported a certain degree of overlap between GERD and FGIDs that it is only partially explained solely by chance. This review evaluated the overlap between GERD but especially FH and different FGIDs as: functional non-cardiac chest pain, irritable bowel syndrome, functional dyspepsia, gastric belching and supragastric belching and pharyngeal globus. A large number of mechanisms have been proposed to elucidate the connection between these numerous conditions. When pathophysiologic tests to subgroup GERD have been performed, FH seems overlap more frequently than GERD with FGIDs. From a therapeutic point of view visceral hypersensitivity, that characterize these functional disorders might be modulated by antidepressant therapy even if there are limited evidences. More studies and especially randomized controlled trials should consider these agents for future agenda researches.

Published
2017

118. OC.09.6 CLINICAL AND IMPEDANCE-PH FACTORS ASSOCIATED TO PPI RESPONSE IN PATIENTS WITH WITH EXTRAESOPHAGEAL SYMPTOMS SUGGESTIVE OF GERD

Author

Svizzero, G. Baiano, primary, Savarino, E., additional, Frazzoni, M., additional, Mauro, A., additional, Tolone, S., additional, Casini, V., additional, Efthymakis, K., additional, Frazzoni, L., additional, Martinucci, I., additional, Marabotto, E., additional, Zentilin, P., additional, Pace, F., additional, Savarino, V., additional, Penagini, R., additional, Neri, M., additional, Marchi, S., additional, and De Bortoli, N., additional

Published
2018
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126. OC.06.5 LOW-FODMAP DIET RESULTED EFFECTIVE IN REDUCING SYMPTOM PERCEPTION IN PATIENTS WITH FUNCTIONAL HEARTBURN: RANDOMIZED, CROSS-OVER CONTROLLED STUDY

Author

Albano, E., primary, De Bortoli, N., additional, Savarino, E., additional, Guidi, G., additional, Nardi, K., additional, Tolone, S., additional, Frazzoni, M., additional, Fuccio, L., additional, Frazzoni, L., additional, Martinucci, I., additional, Bellini, M., additional, Savarino, V., additional, and Marchi, S., additional

Published
2018
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131. P.06.9 MULTIPLE RAPID SWALLOW MIGHT BE HELPFUL TO IMPROVE THE DIAGNOSIS OF INEFFECTIVE ESOPHAGEAL MOTILITY

Author

Tapete, G., primary, Savarino, E., additional, Tolone, S., additional, Mauro, A., additional, Martinucci, I., additional, Marabotto, E., additional, Frazzoni, M., additional, Frazzoni, L., additional, Ceccarelli, L., additional, Bellini, M., additional, Savarino, V., additional, Penagini, R., additional, Marchi, S., additional, and De Bortoli, N., additional

Published
2018
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132. P.07.6 LOW-FODMAPS DIET IMPROVES INTESTINAL SYMPTOMS IN IBD PATIENTS WITH DISEASE REMISSION: RANDOMIZED CASE-CONTROL STUDY

Author

Tapete, G., primary, De Bortoli, N., additional, Ceccarelli, L., additional, Mumolo, M.G., additional, Vinci, E., additional, Albano, E., additional, Bertani, L., additional, Di Fluri, G., additional, Laino, G., additional, Ricchiuti, A., additional, Bellini, M., additional, Marchi, S., additional, and Costa, F., additional

Published
2018
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133. P621 Faecal calprotectin after the induction of anti-TNF therapy predicts mucosal healing in patients with ulcerative colitis: A prospective single-centre study

Author

Bertani, L, primary, de Bortoli, N, additional, Ceccarelli, L, additional, Mumolo, G, additional, Tapete, G, additional, Albano, E, additional, Laino, G, additional, Di Fluri, G, additional, Bellini, M, additional, Ricchiuti, A, additional, Marchi, S, additional, and Costa, F, additional

Published
2018
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136. Voluntary and controlled weight loss can reduce symptoms and proton pump inhibitor use and dosage in patients with gastroesophageal reflux disease: A comparative study

Author

de Bortoli N, Guidi G, Martinucci I, Savarino E, Imam H, Bertani L, Russo S, Franchi R, Macchia L, Manuele Furnari, Ceccarelli L, Savarino V, and Marchi S

Subjects
Adult, Male, Weight loss, Diet, Reducing, Gastroenterology, Proton Pump Inhibitors, GERD, Middle Aged, Overweight, Body Mass Index, Exercise Therapy, Erosive esophagitis, Gastroesophageal Reflux, Esophagitis, Humans, Female, Obesity
Abstract

A wide variety of pieces of evidence has suggested that obesity is associated with a significant increase in the risk for gastroesophageal reflux disease (GERD) symptoms and its complications. The aim of this study was to evaluate the effect of weight loss on reflux symptoms in overweight/obese patients with proven GERD. We enrolled overweight/obese patients with typical GERD symptoms and erosive esophagitis. At baseline, patients underwent detailed reflux symptoms evaluation and anthropometric assessment, and were divided into two treatment groups: group A received proton pump inhibitor (PPI) and a personalized hypocaloric diet and aerobic exercise; and group B received PPI and a 'standard of care diet'. The dietetic treatment was considered effective if at least 10% of weight loss was achieved within 6 months. All patients were evaluated in terms of anthropometric data, GERD symptoms, and PPI use. In group A, mean body mass index (BMI) decreased from 30.3 ± 4.1 to 25.7 ± 3.1 (P0.05), and mean weight decreased from 82.1 ± 16.9 kg to 69.9 ± 14.4 kg (P0.05). In group B, there was no change in BMI and weight. Symptom perception decreased (P0.05) in both groups during PPI therapy, but a higher improvement was recorded in group A. In group A, PPI therapy was completely discontinued in 27/50 of the patients, and halved in 16/50. Only 7/50 continued the same PPI dosage. In group B, 22/51 halved the therapy and 29/51 maintained full dosage of therapy, but none was able to discontinue PPI due to a symptom recurrence. Overall, weight loss of at least 10% is recommended in all patients with GERD in order to boost the effect of PPI on reflux symptom relief and to reduce chronic medication use.

Published
2016

137. The natural history of gastro-esophageal reflux disease: A comprehensive review

Author

Savarino, EDOARDO VINCENZO, de Bortoli, N., DE CASSAN, Chiara, Della Coletta, M., Bartolo, O., Furnari, Manuele, Ottonello, A., Marabotto, Elisa, Bodini, Giorgia, and Savarino, Vincenzo

Subjects
Adult, Male, NERD, GERD, endoscopy, erosive esophagitis, natural history, Natural history, Gastroenterology, Endoscopy, Middle Aged, Erosive esophagitis, Barrett Esophagus, Esophagus, Disease Progression, Gastroesophageal Reflux, Esophagitis, Humans, Female
Abstract

Gastroesophageal reflux disease (GERD) is a common disorder of the upper gastrointestinal tract which is typically characterized by heartburn and acid regurgitation. These symptoms are widespread in the community and range from 2.5% to more than 25%. Economic analyses showed an increase in direct and indirect costs related to the diagnosis, treatment and surveillance of GERD and its complications. The aim of this review is to provide current information regarding the natural history of GERD, taking into account the evolution of its definition and the worldwide gradual change of its epidemiology. Present knowledge shows that there are two main forms of GERD, that is erosive reflux disease (ERD) and non-erosive reflux disease (NERD) and the latter comprises the majority of patients (up to 70%). The major complication of GERD is the development of Barrett esophagus, which is considered as a pre-cancerous lesion. Although data from medical literature on the natural history of this disease are limited and mainly retrospective, they seem to indicate that both NERD and mild esophagitis tend to remain as such with time and the progression from NERD to ERD, from mild to severe ERD and from ERD to Barrett's esophagus may occur in a small proportion of patients, ranging from 0 to 30%, 10 to 22% and 1 to 13% of cases, respectively. It is necessary to stress that these data are strongly influenced by the use of powerful antisecretory drugs (PPIs). Further studies are needed to better elucidate this matter and overcome the present limitations represented by the lack of large prospective longitudinal investigations, absence of homogeneous definitions of the various forms of GERD, influence of different treatments, clear exclusion of patients with functional disorders of the esophagus.

Published
2016

140. OC.15.2: Low-Volume Multiple Rapid Swallow Better Distinguishes Peristaltic Esophageal Reserve Compared to High-Volume Rapid Drinking Test

Author

Natali, V., primary, Savarino, E., additional, Martinucci, I., additional, Tolone, S., additional, Furnari, M., additional, Frazzoni, M., additional, Frazzoni, L., additional, Giannotti, S., additional, Ceccarelli, L., additional, Albano, E., additional, Bertani, L., additional, Costa, F., additional, Savarino, V., additional, Penagini, R., additional, Marchi, S., additional, and De Bortoli, N., additional

Published
2017
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144. P.01.6: Vigor of Contraction is Directly Related to Esophageal Chemical Clearance (PSPW Index)

Author

Fani, B., primary, Savarino, E., additional, Martinucci, I., additional, Tolone, S., additional, Frazzoni, M., additional, Frazzoni, L., additional, Ceccarelli, L., additional, Furnari, M., additional, Surace, L., additional, Ricco, G., additional, Laino, G., additional, Savarino, V., additional, Marchi, S., additional, and De Bortoli, N., additional

Published
2017
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145. P.02.1: Individual Assessment of Gastric Acid Production by Means of a Non-Invasive Test: Relationship Between Maximal Acid Output and Serum Pepsinogen I Levels in Patients with Different Upper GI Diseases

Author

Di Mario, F., primary, Scida, S., additional, Miraglia, C., additional, Franceschi, M., additional, Bertelè, A., additional, Cannizzaro, R., additional, Dal Bò, N., additional, Savarino, E., additional, De Bortoli, N., additional, Rugge, M., additional, and Scarpignato, C., additional

Published
2017
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146. OC.15.1: High-Volume Rapid Drinking test Better Distinguishes Esophageal Body Inhibition Compared to Low-Volume Multiple Rapid Swallows

Author

Giannotti, S., primary, Savarino, E., additional, Martinucci, I., additional, Marzio, F., additional, Russo, S., additional, Frazzoni, L., additional, Tolone, S., additional, Marabotto, E., additional, Ceccarelli, L., additional, Melissari, S., additional, Bellini, M., additional, Savarino, V., additional, Penagini, R., additional, Marchi, S., additional, and De Bortoli, N., additional

Published
2017
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148. OC.15.4: High Resolution Manometry Should be Considered the best Test to Diagnose Sliding Hiatal Hernia

Author

Sellitri, R., primary, De Bortoli, N., additional, Savarino, E., additional, Martinucci, I., additional, Tolone, S., additional, Frazzoni, M., additional, Marabotto, E., additional, Frazzoni, L., additional, Ricco, G., additional, Surace, L., additional, Laino, G., additional, Ceccarelli, L., additional, Bellini, M., additional, Savarino, V., additional, and Marchi, S., additional

Published
2017
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149. OC.15.5: Post-Reflux Swallow-Induced Peristaltic wave Index and Mean Nocturnal Baseline Impedance Predict Heartburn Response to Proton PUMP Inhibitors Better than Acid Exposure Time

Author

Frazzoni, L., primary, Frazzoni, M., additional, De Bortoli, N., additional, Tolone, S., additional, Furnari, M., additional, Martinucci, I., additional, Marchi, S., additional, Conigliaro, R., additional, Fuccio, L., additional, Bazzoli, F., additional, Savarino, V., additional, and Savarino, E., additional

Published
2017
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