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105. Sex-specific benefits of sirolimus-eluting stent on long-term outcomes in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: Insights from the Multicenter Evaluation of Single High-Dose Bolus Tirofiban Versus Abciximab With Sirolimus-Eluting Stent or Bare-Metal Stent in Acute Myocardial Infarction Study trial

Author

Ferrante, Giuseppe, Presbitero, Patrizia, Corrada, Elena, Campo, Gianluca, Bolognese, Leonardo, Vassanelli, Corrado, Colangelo, Salvatore, De Cesare, Nicoletta, Rodriguez, Alfredo E., Bramucci, Ezio, Moreno, Raul, Piva, Tommaso, Sheiban, Imad, Pasquetto, Giampaolo, Prati, Francesco, Nazzaro, Marco S., Ferrari, Roberto, and Valgimigli, Marco

Published
2012
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108. PRECISE-DAPT score for bleeding risk prediction in patients on dual or single antiplatelet regimens: insights from the GLOBAL LEADERS and GLASSY

Author

Gragnano, Felice, primary, Heg, Dik, additional, Franzone, Anna, additional, McFadden, Eugène P, additional, Leonardi, Sergio, additional, Piccolo, Raffaele, additional, Vranckx, Pascal, additional, Branca, Mattia, additional, Serruys, Patrick W, additional, Benit, Edouard, additional, Liebetrau, Christoph, additional, Janssens, Luc, additional, Ferrario, Maurizio, additional, Zurakowski, Aleksander, additional, Diletti, Roberto, additional, Dominici, Marcello, additional, Huber, Kurt, additional, Slagboom, Ton, additional, Buszman, Paweł, additional, Bolognese, Leonardo, additional, Tumscitz, Carlo, additional, Bryniarski, Krzysztof, additional, Aminian, Adel, additional, Vrolix, Mathias, additional, Petrov, Ivo, additional, Garg, Scot, additional, Naber, Christoph, additional, Prokopczuk, Janusz, additional, Hamm, Christian, additional, Steg, Philippe Gabriel, additional, Jüni, Peter, additional, Windecker, Stephan, additional, and Valgimigli, Marco, additional

Published
2020
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111. An autoantibody profile detects Brugada syndrome and identifies abnormally expressed myocardial proteins

Author

Chatterjee, Diptendu, primary, Pieroni, Maurizio, additional, Fatah, Meena, additional, Charpentier, Flavien, additional, Cunningham, Kristopher S, additional, Spears, Danna A, additional, Chatterjee, Dipashree, additional, Suna, Gonca, additional, Bos, J Martjin, additional, Ackerman, Michael J, additional, Schulze-Bahr, Eric, additional, Dittmann, Sven, additional, Notarstefano, Pasquale G, additional, Bolognese, Leonardo, additional, Duru, Firat, additional, Saguner, Ardan M, additional, and Hamilton, Robert M, additional

Published
2020
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117. Impact of recruitment and retention on all-cause mortality in a large all-comers randomised controlled trial: insights from the GLOBAL LEADERS trial

Author

Takahashi, Kuniaki, primary, Kogame, Norihiro, additional, Tomaniak, Mariusz, additional, Chichareon, Ply, additional, Chang, Chun-Chin, additional, Modolo, Rodrigo, additional, Benit, Edouard, additional, Liebetrau, Christoph, additional, Janssens, Luc, additional, Ferrario, Maurizio, additional, Zurakowski, Aleksander, additional, van Geuns, Robert Jan, additional, Dominici, Marcello, additional, Huber, Kurt, additional, Buszman, Pawel, additional, Bolognese, Leonardo, additional, Tumscitz, Carlo, additional, Żmudka, Krzysztof, additional, Aminian, Adel, additional, Vrolix, Mathias, additional, Petrov, Ivo, additional, Wykrzykowska, Joanna J., additional, de Winter, Robbert J., additional, Hamm, Christian, additional, Steg, Philippe Gabriel, additional, Onuma, Yoshinobu, additional, Valgimigli, Marco, additional, Windecker, Stephan, additional, Vranckx, Pascal, additional, Garg, Scot, additional, and Serruys, Patrick W., additional

Published
2019
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119. [Dual antiplatelet therapy in elderly patients with acute coronary syndrome: does age make the difference?]

Author

Tarantini, Giuseppe, Cirillo, Plinio, De Servi, Stefano, Parodi, Guido, Capodanno, Davide, D'Amico, Gianpiero, Boccanelli, Alessandro, Cattaneo, Marco, Bolognese, Leonardo, Cavallini, Claudio, Musumeci, Giuseppe, Marchionni, Niccolò, Tarantini, Giuseppe, Cirillo, Plinio, De Servi, Stefano, Parodi, Guido, Capodanno, Davide, D'Amico, Gianpiero, Boccanelli, Alessandro, Cattaneo, Marco, Bolognese, Leonardo, Cavallini, Claudio, Musumeci, Giuseppe, and Marchionni, Niccolò

Subjects
DAPT, ACS, Elderly
Abstract

The appropriate use of dual antiplatelet therapy (DAPT) in elderly patients with acute coronary syndrome (ACS) remains a highly debated subject. In fact, achieving the correct balance between the reduction of ischemic risk and the increase in hemorrhagic events is more difficult in this population than in younger subjects, especially in the case of very potent drug therapy. As a consequence of this, despite guideline recommendations, antiplatelet therapy is currently underutilized in elderly patients with ACS.In current clinical practice, the antiplatelet drugs that can be used in combination with aspirin are clopidogrel, prasugrel and ticagrelor. The efficacy of these molecules is supported by randomized clinical trials, which gave variable results in terms of the extent of reduction in ischemic events and increase in hemorrhagic complications. The purpose of this article is to identify, based on the results of a consensus meeting, common elements in the use of DAPT in the elderly and to identify areas where further scientific evidence is required to better define the role of the individual antiplatelet agents.

Published
2018

120. Systematic primary angioplasty in octogenarian and older patients

Author

Antoniucci, David, Valenti, Renato, Santoro, Giovanni M., Bolognese, Leonardo, Moschi, Guia, Trapani, Maurizio, Taddeucci, Enrica, and Fazzini, Pier Filippo

Subjects
Heart attack -- Care and treatment, Transluminal angioplasty -- Evaluation, Aged patients -- Care and treatment, Health
Published
1999

122. The role of European national journals in education

Author

Mills, Peter, Timmis, Adam, Huber, Kurt, Ector, Hugo, Lancellotti, Patrizio, Masic, Izet, Ivanusa, Mario, Antoniades, Loizos, Aschermann, Michael, Laucevicius, Alexandras, Mustonen, Pirjo, Artigou, Jean-Yves, Vardas, Panos, Stefanadis, Christodoulos, Chiarello, Massimo, Bolognese, Leonardo, Ambrosio, Guiseppe, van der Wall, Ernst E, Kułakowski, Piotr, Pinto, Fausto J, Apetrei, Eduard, Oganov, Rafael G, Kamensky, Gabriel, Lüscher, Thomas F, Lerch, René, Haouala, Habib, Sansoy, Vedat, Shumakov, Valentin, Tajer, Carlos Daniel, Lau, Chu-Pak, Márquez, Manlio, Krittayaphong, Rungroj, Arai, Kaduo, and Alfonso, Fernando

Published
2009
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123. Ostial and midshaft lesions vs. bifurcation lesions in 1111 patients with unprotected left main coronary artery stenosis treated with drug-eluting stents: results of the survey from the Italian Society of Invasive Cardiology

Author

Palmerini, Tullio, Sangiorgi, Diego, Marzocchi, Antonio, Tamburino, Corrado, Sheiban, Imad, Margheri, Massimo, Vecchi, Giuseppe, Sangiorgi, Giuseppe, Ruffini, Michele, Bartorelli, Antonio L., Briguori, Carlo, Vignali, Luigi, Di Pede, Francesco, Ramondo, Angelo, Inglese, Luigi, De Carlo, Marco, Bolognese, Leonardo, Benassi, Alberto, Palmieri, Cataldo, Filippone, Vincenzo, Barlocco, Fabio, Lauria, Giulia, and De Servi, Stefano

Published
2009

124. Are drug-eluting stents superior to bare-metal stents in patients with unprotected non-bifurcational left main disease? Insights from a multicentre registry

Author

Tamburino, Corrado, Di Salvo, Maria Elena, Capodanno, Davide, Marzocchi, Antonio, Sheiban, Imad, Margheri, Massimo, Maresta, Aleardo, Barlocco, Fabio, Sangiorgi, Giuseppe, Piovaccari, Giancarlo, Bartorelli, Antonio, Briguori, Carlo, Ardissino, Diego, Di Pede, Francesco, Ramondo, Angelo, Inglese, Luigi, Petronio, Anna Sonia, Bolognese, Leonardo, Benassi, Alberto, Palmieri, Cataldo, Patti, Aldo, and De Servi, Stefano

Published
2009

125. Long-term clinical benefit of drug-eluting stents over bare-metal stents in diabetic patients with de novo left main coronary artery disease: Results from a real-world multicenter registry

Author

Capodanno, Davide, Di Salvo, Maria Elena, Palmerini, Tullio, Sheiban, Imad, Margheri, Massimo, Vecchi, Giuseppe, Sangiorgi, Giuseppe, Piovaccari, Giancarlo, Bartorelli, Antonio, Briguori, Carlo, Ardissino, Diego, Di Pede, Francesco, Ramondo, Angelo, Inglese, Luigi, Petronio, Anna Sonia, Bolognese, Leonardo, Benassi, Alberto, Palmieri, Cataldo, Filippone, Vincenzo, De Servi, Stefano, and Tamburino, Corrado

Published
2009
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126. Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction:ATLANTIC-Morphine

Author

Lapostolle, Frederic, van't Hof, Arnoud W., Hamm, Christian W., Stibbe, Olivier, Ecollan, Patrick, Collet, Jean-Philippe, Silvain, Johanne, Lassen, Jens Flensted, Heutz, Wim M. J. M., Bolognese, Leonardo, Cantor, Warren J., Cequier, Angel, Chettibi, Mohamed, Goodman, Shaun G., Hammett, Christopher, Huber, Kurt, Janzon, Magnus, Merkely, Bela, Storey, Robert F., ten Berg, Jur, Zeymer, Uwe, Licour, Muriel, Tsatsaris, Anne, Montalescot, Gilles, Bougherbal, Rachid, Bouafia, Mohamed Tahar, Nibouche, Djamaleddine, Moklati, Abdelkader, Benalia, Ahmed, Krim, Messaad, Garraby, Paul, Jayasinghe, Rohan, Rashford, Stephen, Neunteufl, Thomas, Brussee, Helmut, Alber, Hannes, Weidinger, Franz, Baubin, Michael, Sebald, Dieter, Cantor, Warren, Vijayaraghavan, Ram, Bata, Iqbal, Lavoie, Andrea, Ravkilde, Jan, Jensen, Lisette Okkels, Christensen, Alf Mol, Université Sorbonne Paris Cité (USPC), Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Brigade de sapeurs pompiers de Paris (BSPP), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), Aarhus University Hospital, University of Toronto, University of Barcelona, Centre Hospitalo-Universitaire de Blida (CHU Blida), St. Michael's Hospital, Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), Linköping University (LIU), Semmelweis University of Medicine [Budapest], University of Sheffield [Sheffield], St. Antonius Hospital [Nieuwegein], AstraZeneca, RS: Carim - H01 Clinical atrial fibrillation, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), and RS: CARIM - R2.01 - Clinical atrial fibrillation

Subjects
Male, Ticagrelor, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Chest pain, DOUBLE-BLIND, 0302 clinical medicine, PRASUGREL, REPERFUSION, Pharmacology (medical), 030212 general & internal medicine, Myocardial infarction, Stroke, OUTCOMES, Morphine, General Medicine, Thrombolysis, ASSOCIATION, Middle Aged, 3. Good health, Analgesics, Opioid, INSIGHTS, Treatment Outcome, surgical procedures, operative, Cardiology, Female, TRIAL, medicine.symptom, Cardiology and Cardiovascular Medicine, TIMI, medicine.drug, Adult, medicine.medical_specialty, Pain, Platelet Glycoprotein GPIIb-IIIa Complex, Revascularization, 03 medical and health sciences, Percutaneous Coronary Intervention, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, Humans, cardiovascular diseases, Aged, Retrospective Studies, business.industry, Percutaneous coronary intervention, medicine.disease, ST Elevation Myocardial Infarction, business, Platelet Aggregation Inhibitors
Abstract

Background: Morphine adversely impacts the action of oral adenosine diphosphate (ADP)-receptor blockers in ST-segment elevation myocardial infarction (STEMI) patients, and is possibly associated with differing patient characteristics. This retrospective analysis investigated whether interaction between morphine use and pre-percutaneous coronary intervention (pre-PCI) ST-segment elevation resolution in STEMI patients in the ATLANTIC study was associated with differences in patient characteristics and management. Methods: ATLANTIC was an international, multicenter, randomized study of treatment in the acute ambulance/hospital setting where STEMI patients received ticagrelor 180 mg ± morphine. Patient characteristics, cardiovascular history, risk factors, management, and outcomes were recorded. Results: Opioids (97.6% morphine) were used in 921 out of 1862 patients (49.5%). There were no significant differences in age, sex or cardiovascular history, but more morphine-treated patients had anterior myocardial infarction and left-main disease. Time from chest pain to electrocardiogram and ticagrelor loading was shorter with morphine (both p = 0.01) but not total ischemic time. Morphine-treated patients more frequently received glycoprotein IIb/IIIa inhibitors (p = 0.002), thromboaspiration and stent implantation (both p < 0.001). No significant difference between the two groups was found regarding pre-PCI ≥ 70% ST-segment elevation resolution, death, myocardial infarction, stroke, urgent revascularization and definitive acute stent thrombosis. More morphine-treated patients had an absence of pre-PCI Thrombolysis in Myocardial Infarction (TIMI) 3 flow (85.8% vs. 79.7%; p = 0.001) and more had TIMI major bleeding (1.1% vs. 0.1%; p = 0.02). Conclusions: Morphine-treatment was associated with increased GP IIb/IIIa inhibitor use, less pre-PCI TIMI 3 flow, and more bleeding. Judicious morphine use is advised with non-opioid analgesics preferred for non-severe acute pain. Trial Registration: clinicaltrials.gov identifier: NCT01347580.

Published
2019

127. Two-by-two factorial comparison of high-bolus-dose tirofiban followed by standard infusion versus abciximab and sirolimus-eluting versus bare-metal stent implantation in patients with acute myocardial infarction: Design and rationale for the MULTI-STRATEGY trial

Author

Valgimigli, Marco, Bolognese, Leonardo, Anselmi, Maurizio, Campo, Gianluca, Rodriguez, Alfredo E., de Cesare, Nicoletta, Cohen, David J., Sheiban, Imad, Colangelo, Salvatore, Pasquetto, Giampaolo, Hamon, Martial, Vranckx, Pascal, Ferrario, Maurizio, Prati, Francesco, Agostoni, Pierfrancesco, Malagutti, Patrizia, Arcozzi, Chiara, Parrinello, Giovanni, Vassanelli, Corrado, Ferrari, Roberto, and Percoco, Gianfranco

Published
2007

128. Restenosis after coronary stenting in current clinical practice

Author

Antoniucci, David, Valenti, Renato, Santoro, Giovanni M., Bolognese, Leonardo, Trapani, Maurizio, Cerisano, Giampaolo, Boddi, Vieri, and Fazzini, Pier Filippo

Subjects
Stent (Surgery) -- Complications, Arteries -- Stenosis, Health
Published
1998

133. Pre-hospital administration of ticagrelor in diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty : A sub-analysis of the ATLANTIC trial

Author

Fabris, Enrico, Van't Hof, Arnoud, Hamm, Christian W, Lapostolle, Frédéric, Lassen, Jens Flensted, Goodman, Shaun G, Ten Berg, Jurriën M, Bolognese, Leonardo, Cequier, Angel, Chettibi, Mohamed, Hammett, Christopher J, Huber, Kurt, Janzon, Magnus, Merkely, Béla, Storey, Robert F, Zeymer, Uwe, Cantor, Warren J, Kerneis, Mathieu, Diallo, Abdourahmane, Vicaut, Eric, Montalescot, Gilles, Fabris, Enrico, Van't Hof, Arnoud, Hamm, Christian W, Lapostolle, Frédéric, Lassen, Jens Flensted, Goodman, Shaun G, Ten Berg, Jurriën M, Bolognese, Leonardo, Cequier, Angel, Chettibi, Mohamed, Hammett, Christopher J, Huber, Kurt, Janzon, Magnus, Merkely, Béla, Storey, Robert F, Zeymer, Uwe, Cantor, Warren J, Kerneis, Mathieu, Diallo, Abdourahmane, Vicaut, Eric, and Montalescot, Gilles

Abstract

OBJECTIVE: We investigated, in the contemporary era of ST-elevation myocardial infarction (STEMI) treatment, the influence of diabetes mellitus (DM) on cardiovascular outcomes, and whether pre-hospital administration of ticagrelor may affect these outcomes in a subgroup of STEMI patients with DM. BACKGROUND: DM patients have high platelet reactivity and a prothrombotic condition which highlight the importance of an effective antithrombotic regimen in this high-risk population. METHODS: In toal 1,630 STEMI patients enrolled in the ATLANTIC trial who underwent primary percutaneous coronary intervention (PCI) were included. Multivariate analysis was used to explore the association of DM with outcomes and potential treatment-by-diabetes interaction was tested. RESULTS: A total of 214/1,630 (13.1%) patients had DM. DM was an independent predictor of poor myocardial reperfusion as reflected by less frequent ST-segment elevation resolution (≥70%) after PCI (OR 0.59, 95% CI 0.43-0.82, P < 0.01) and was an independent predictor of the composite 30-day outcomes of death/new myocardial infarction (MI)/urgent revascularization/definite stent thrombosis (ST) (OR 2.80, 95% CI 1.62-4.85, P < 0.01), new MI or definite acute ST (OR 2.46, 95% CI 1.08-5.61, P = 0.03), and definite ST (OR 10.00, 95% CI 3.54-28.22, P < 0.01). No significant interaction between pre-hospital ticagrelor vs in-hospital ticagrelor administration and DM was present for the clinical, electrocardiographic and angiographic outcomes as well as for thrombolysis in myocardial infarction major bleeding. CONCLUSIONS: DM remains independently associated with poor myocardial reperfusion and worse 30-day clinical outcomes. No significant interaction was found between pre-hospital vs in-hospital ticagrelor administration and DM status. Further approaches for the treatment of DM patients are needed. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT01347580., Funding agencies: Astrazeneca

Published
2019
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134. Clinical impact and predictors of complete ST segment resolution after primary percutaneous coronary intervention : A subanalysis of the ATLANTIC Trial

Author

Fabris, Enrico, van 't Hof, Arnoud, Hamm, Christian W, Lapostolle, Frédéric, Lassen, Jens F, Goodman, Shaun G, Ten Berg, Jurriën M, Bolognese, Leonardo, Cequier, Angel, Chettibi, Mohamed, Hammett, Christopher J, Huber, Kurt, Janzon, Magnus, Merkely, Béla, Storey, Robert F, Zeymer, Uwe, Cantor, Warren J, Tsatsaris, Anne, Kerneis, Mathieu, Diallo, Abdourahmane, Vicaut, Eric, Montalescot, Gilles, Fabris, Enrico, van 't Hof, Arnoud, Hamm, Christian W, Lapostolle, Frédéric, Lassen, Jens F, Goodman, Shaun G, Ten Berg, Jurriën M, Bolognese, Leonardo, Cequier, Angel, Chettibi, Mohamed, Hammett, Christopher J, Huber, Kurt, Janzon, Magnus, Merkely, Béla, Storey, Robert F, Zeymer, Uwe, Cantor, Warren J, Tsatsaris, Anne, Kerneis, Mathieu, Diallo, Abdourahmane, Vicaut, Eric, and Montalescot, Gilles

Abstract

BACKGROUND: In the ATLANTIC (Administration of Ticagrelor in the catheterization laboratory or in the Ambulance for New ST elevation myocardial Infarction to open the Coronary artery) trial the early use of aspirin, anticoagulation, and ticagrelor coupled with very short medical contact-to-balloon times represent good indicators of optimal treatment of ST-elevation myocardial infarction and an ideal setting to explore which factors may influence coronary reperfusion beyond a well-established pre-hospital system. METHODS: This study sought to evaluate predictors of complete ST-segment resolution after percutaneous coronary intervention in ST-elevation myocardial infarction patients enrolled in the ATLANTIC trial. ST-segment analysis was performed on electrocardiograms recorded at the time of inclusion (pre-hospital electrocardiogram), and one hour after percutaneous coronary intervention (post-percutaneous coronary intervention electrocardiogram) by an independent core laboratory. Complete ST-segment resolution was defined as ≥70% ST-segment resolution. RESULTS: Complete ST-segment resolution occurred post-percutaneous coronary intervention in 54.9% ( n=800/1456) of patients and predicted lower 30-day composite major adverse cardiovascular and cerebrovascular events (odds ratio 0.35, 95% confidence interval 0.19-0.65; p<0.01), definite stent thrombosis (odds ratio 0.18, 95% confidence interval 0.02-0.88; p=0.03), and total mortality (odds ratio 0.43, 95% confidence interval 0.19-0.97; p=0.04). In multivariate analysis, independent negative predictors of complete ST-segment resolution were the time from symptoms to pre-hospital electrocardiogram (odds ratio 0.91, 95% confidence interval 0.85-0.98; p<0.01) and diabetes mellitus (odds ratio 0.6, 95% confidence interval 0.44-0.83; p<0.01); pre-hospital ticagrelor treatment showed a favorable trend for complete ST-segment resolution (odds ratio 1.22, 95% confidence interval 0.99-1.51; p=0.06). CONCLUSIONS: This s, Funding agencies: AstraZeneca

Published
2019
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135. Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction : ATLANTIC-Morphine

Author

Lapostolle, Frédéric, Van't Hof, Arnoud W, Hamm, Christian W, Stibbe, Olivier, Ecollan, Patrick, Collet, Jean-Philippe, Silvain, Johanne, Lassen, Jens Flensted, Heutz, Wim M J M, Bolognese, Leonardo, Cantor, Warren J, Cequier, Angel, Chettibi, Mohamed, Goodman, Shaun G, Hammett, Christopher J, Huber, Kurt, Janzon, Magnus, Merkely, Béla, Storey, Robert F, Ten Berg, Jur, Zeymer, Uwe, Licour, Muriel, Tsatsaris, Anne, Montalescot, Gilles, Lapostolle, Frédéric, Van't Hof, Arnoud W, Hamm, Christian W, Stibbe, Olivier, Ecollan, Patrick, Collet, Jean-Philippe, Silvain, Johanne, Lassen, Jens Flensted, Heutz, Wim M J M, Bolognese, Leonardo, Cantor, Warren J, Cequier, Angel, Chettibi, Mohamed, Goodman, Shaun G, Hammett, Christopher J, Huber, Kurt, Janzon, Magnus, Merkely, Béla, Storey, Robert F, Ten Berg, Jur, Zeymer, Uwe, Licour, Muriel, Tsatsaris, Anne, and Montalescot, Gilles

Abstract

BACKGROUND: Morphine adversely impacts the action of oral adenosine diphosphate (ADP)-receptor blockers in ST-segment elevation myocardial infarction (STEMI) patients, and is possibly associated with differing patient characteristics. This retrospective analysis investigated whether interaction between morphine use and pre-percutaneous coronary intervention (pre-PCI) ST-segment elevation resolution in STEMI patients in the ATLANTIC study was associated with differences in patient characteristics and management. METHODS: ATLANTIC was an international, multicenter, randomized study of treatment in the acute ambulance/hospital setting where STEMI patients received ticagrelor 180 mg ± morphine. Patient characteristics, cardiovascular history, risk factors, management, and outcomes were recorded. RESULTS: Opioids (97.6% morphine) were used in 921 out of 1862 patients (49.5%). There were no significant differences in age, sex or cardiovascular history, but more morphine-treated patients had anterior myocardial infarction and left-main disease. Time from chest pain to electrocardiogram and ticagrelor loading was shorter with morphine (both p = 0.01) but not total ischemic time. Morphine-treated patients more frequently received glycoprotein IIb/IIIa inhibitors (p = 0.002), thromboaspiration and stent implantation (both p < 0.001). No significant difference between the two groups was found regarding pre-PCI ≥ 70% ST-segment elevation resolution, death, myocardial infarction, stroke, urgent revascularization and definitive acute stent thrombosis. More morphine-treated patients had an absence of pre-PCI Thrombolysis in Myocardial Infarction (TIMI) 3 flow (85.8% vs. 79.7%; p = 0.001) and more had TIMI major bleeding (1.1% vs. 0.1%; p = 0.02). CONCLUSIONS: Morphine-treatment was associated with increased GP IIb/IIIa inhibitor use, less pre-PCI TIMI 3 flow, and more bleeding. Judicious morphine use is advised with non-opioid analgesics preferred for non-severe acute pain. TRI

Published
2019
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138. Introduction

Author

Antoniucci, David, Bolognese, Leonardo, and Santoro, Giovanni M.

Published
1999

139. European Society of Cardiology: Cardiovascular Disease Statistics 2017

Author

Timmis, Adam, Townsend, Nick, Gale, Chris, Grobbee, Rick, Maniadakis, Nikos, Flather, Marcus, Wilkins, Elizabeth, Wright, Lucy, Vos, Rimke, Bax, Jeroen, Blum, Maxim, Logstrup, Susanne, Pinto, Fausto J., Vardas, Panos, Goda, Artan, Demiraj, Aurel F, Weidinger, Franz, Metzler, Bernard, Ibrahimov, Firdovsi, Pasquet, Agnes A, Claeys, Marc, Thorton, Yolanda, Kusljugic, Zumreta, Smajic, Elnur, Velchev, Vasil, Ivanov, Nikolay, Antoniades, Loizos, Agathangelou, Petros, Táborský, Miloš, Gerdes, Christian, Viigima, Margus, Juhani, Pietila Mikko, Juilliere, Yves, Cattan, Simon, Aladashvili, Alexander, Hamm, Christian, Kuck, Karl-Heinz, Papoutsis, Konstantinos, Bestehorn, Kurt, Foussas, Stefanos, Giannoulidou, Georgia, Varounis, Christos, Kallikazaros, Ioannis, Kiss, Robert Gabor, Czétényi, Tunde, Becker, Dávid, Gudnason, Thorarinn, Kearney, Peter, McDonald, Kenneth, Rozenman, Yoseph, Ziv, Batia, Bolognese, Leonardo, Luciolli, Paola, Boriani, Giuseppe, Berkinbayev, Salim, Rakisheva, Amina, Mirrakhimov, Erkin, Erglis, Andrejs, Jegere, Sandra, Marinskis, Germanas, Beissel, Jean, Marchal, Nathalie, Kedev, Sasko, Xuereb, Robert G, Tilney, Terence, Felice, Tiziana, Popovici, Mihail, Mulder, Barbara, Simoons, Maarten, Elsendoorn, Moniek, Steigen, Terje K, Atar, Dan, Kalarus, Zbigniew, Tendera, Michal, Cardoso, Jose Silva, Ribeiro, José, Mateus, Cristina, Tatu-Chitoiu, Gabriel, Seferovic, Petar, Beleslin, Branko, Simkova, Iveta, Durcikova, Petra, Belicova, Veronica, Fras, Zlatko, Radelj, Sasa, Gonzalez Juanatey, Jose Ramon, Legendre, Sharon, Braunschweig, Frieder, Kaufmann, Urs Philipp, Rudiger-Sturchler, Marjam, Tokgozoglu, Lale, Unver, Ahmet, Kovalenko, Volodymir, Nesukay, Elena, Naum, Anastasia, de Courtelary, Paola Thellung, Martin, Stephan, Sebastiao, David, Ghislain, Daval, Bardinet, Isabel, and Repositório da Universidade de Lisboa

Subjects
medicine.medical_specialty, Inequality, media_common.quotation_subject, Health infrastructure, Disease, 030204 cardiovascular system & hematology, European Society of Cardiology, 03 medical and health sciences, 0302 clinical medicine, Economic indicator, Internal medicine, Health care, Statistics, medicine, Cardiovascular disease, Morbidity, Mortality, Risk factors, Service provision, Cardiology and Cardiovascular Medicine, 030212 general & internal medicine, Disease burden, Cause of death, media_common, business.industry, medicine.disease, Obesity, Years of potential life lost, Cardiology, business
Abstract

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com., Aims: The European Society of Cardiology (ESC) Atlas has been compiled by the European Heart Agency to document cardiovascular disease (CVD) statistics of the 56 ESC member countries. A major aim of this 2017 data presentation has been to compare high-income and middle-income ESC member countries to identify inequalities in disease burden, outcomes, and service provision. Methods and results: The Atlas utilizes a variety of data sources, including the World Health Organization, the Institute for Health Metrics and Evaluation, and the World Bank to document risk factors, prevalence, and mortality of cardiovascular disease and national economic indicators. It also includes novel ESC-sponsored survey data of health infrastructure and cardiovascular service provision provided by the national societies of the ESC member countries. Data presentation is descriptive with no attempt to attach statistical significance to differences observed in stratified analyses. Important differences were identified between the high-income and middle-income member countries of the ESC with regard to CVD risk factors, disease incidence, and mortality. For both women and men, the age-standardized prevalence of hypertension was lower in high-income countries (18% and 27%) compared with middle-income countries (24% and 30%). Smoking prevalence in men (not women) was also lower (26% vs. 41%) and together these inequalities are likely to have contributed to the higher CVD mortality in middle-income countries. Declines in CVD mortality have seen cancer becoming a more common cause of death in a number of high-income member countries, but in middle-income countries declines in CVD mortality have been less consistent where CVD remains the leading cause of death. Inequalities in CVD mortality are emphasized by the smaller contribution they make to potential years of life lost in high-income countries compared with middle-income countries both for women (13% vs. 23%) and men (20% vs. 27%). The downward mortality trends for CVD may, however, be threatened by the emerging obesity epidemic that is seeing rates of diabetes increasing across all the ESC member countries. Survey data from the National Cardiac Societies showed that rates of cardiac catheterization and coronary artery bypass surgery, as well as the number of specialist centres required to deliver them, were greatest in the high-income member countries of the ESC. The Atlas confirmed that these ESC member countries, where the facilities for the contemporary treatment of coronary disease were best developed, were often those in which declines in coronary mortality have been most pronounced. Economic resources were not the only driver for delivery of equitable cardiovascular health care, as some middle-income ESC member countries reported rates for interventional procedures and device implantations that matched or exceeded the rates in wealthier member countries. Conclusion: In documenting national CVD statistics, the Atlas provides valuable insights into the inequalities in risk factors, health care delivery, and outcomes of CVD across the ESC member countries. The availability of these data will underpin the ESC’s ambitious mission ‘to reduce the burden of cardiovascular disease’ not only in its member countries but also in nation states around the world.

Published
2018

140. Impact of long-term ticagrelor monotherapy following 1-month dual antiplatelet therapy in patients who underwent complex percutaneous coronary intervention: insights from the Global Leaders trial

Author

Serruys, Patrick W, primary, Takahashi, Kuniaki, additional, Chichareon, Ply, additional, Kogame, Norihiro, additional, Tomaniak, Mariusz, additional, Modolo, Rodrigo, additional, Chang, Chun Chin, additional, Komiyama, Hidenori, additional, Soliman, Osama, additional, Wykrzykowska, Joanna J, additional, de Winter, Robbert J, additional, Ferrario, Maurizio, additional, Dominici, Marcello, additional, Buszman, Paweł, additional, Bolognese, Leonardo, additional, Tumscitz, Carlo, additional, Benit, Edouard, additional, Stoll, Hans-Peter, additional, Hamm, Christian, additional, Steg, Philippe Gabriel, additional, Onuma, Yoshinobu, additional, Jüni, Peter, additional, Windecker, Stephan, additional, Vranckx, Pascal, additional, Colombo, Antonio, additional, and Valgimigli, Marco, additional

Published
2019
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141. Validation of the updated logistic clinical SYNTAX score for all-cause mortality in the GLOBAL LEADERS trial

Author

Chichareon, Ply, primary, Onuma, Yoshinobu, additional, van Klaveren, David, additional, Modolo, Rodrigo, additional, Kogame, Norihiro, additional, Takahashi, Kuniaki, additional, Chang, Chun Chin, additional, Tomaniak, Mariusz, additional, Asano, Taku, additional, Katagiri, Yuki, additional, van Geuns, Robert-Jan M., additional, Bolognese, Leonardo, additional, Tumscitz, Carlo, additional, Vrolix, Mathias, additional, Petrov, Ivo, additional, Garg, Scot, additional, Naber, Christoph Kurt, additional, Sabaté, Manel, additional, Iqbal, Javaid, additional, Wykrzykowska, Joanna J., additional, Piek, Jan J., additional, Spitzer, Ernest, additional, Jüni, Peter, additional, Hamm, Christian, additional, Steg, Philippe Gabriel, additional, Valgimigli, Marco, additional, Vranckx, Pascal, additional, Windecker, Stephan, additional, and Serruys, Patrick W., additional

Published
2019
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145. Reply

Author

Pieroni, Maurizio, primary, Notarstefano, Pasquale, additional, Oliva, Antonio, additional, Santangeli, Pasquale, additional, and Bolognese, Leonardo, additional

Published
2019
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146. Rationale and design of a prospective substudy of clinical endpoint adjudication processes within an investigator-reported randomised controlled trial in patients with coronary artery disease: the GLOBAL LEADERS Adjudication Sub-StudY (GLASSY)

Author

Leonardi, Sergio, primary, Franzone, Anna, additional, Piccolo, Raffaele, additional, McFadden, Eugene, additional, Vranckx, Pascal, additional, Serruys, Patrick, additional, Benit, Edouard, additional, Liebetrau, Christoph, additional, Janssens, Luc, additional, Ferrario, Maurizio, additional, Zurakowski, Aleksander, additional, van Geuns, Robert-Jan, additional, Dominici, Marcello, additional, Huber, Kurt, additional, Slagboom, Ton, additional, Buszman, Paweł, additional, Bolognese, Leonardo, additional, Tumscitz, Carlo, additional, Bryniarski, Krzysztof, additional, Aminian, Adel, additional, Vrolix, Mathias, additional, Petrov, Ivo, additional, Garg, Scot, additional, Naber, Christoph, additional, Prokopczuk, Janusz, additional, Hamm, Christian, additional, Steg, Gabriel, additional, Heg, Dik, additional, Juni, Peter, additional, Windecker, Stephan, additional, and Valgimigli, Marco, additional

Published
2019
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147. Time Course of Ischemic and Bleeding Burden in Elderly Patients With Acute Coronary Syndromes Randomized to Low‐Dose Prasugrel or Clopidogrel

Author

Crimi, Gabriele, primary, Morici, Nuccia, additional, Ferrario, Maurizio, additional, Ferri, Luca A., additional, Piatti, Luigi, additional, Grosseto, Daniele, additional, Cacucci, Michele, additional, Mandurino Mirizzi, Alessandro, additional, Toso, Anna, additional, Piscione, Federico, additional, De Carlo, Marco, additional, Elia, Luigi Raffaele, additional, Trimarco, Bruno, additional, Bolognese, Leonardo, additional, Bovenzi, Francesco M., additional, De Luca, Giuseppe, additional, Savonitto, Stefano, additional, and De Servi, Stefano, additional

Published
2019
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148. PRECISE-DAPT score for bleeding risk prediction in patients on dual or single antiplatelet regimens: insights from the GLOBAL LEADERS and GLASSY

Author

Gragnano, Felice, Heg, Dik, Franzone, Anna, McFadden, Eugène P, Leonardi, Sergio, Piccolo, Raffaele, Vranckx, Pascal, Branca, Mattia, Serruys, Patrick W, Benit, Edouard, Liebetrau, Christoph, Janssens, Luc, Ferrario, Maurizio, Zurakowski, Aleksander, Diletti, Roberto, Dominici, Marcello, Huber, Kurt, Slagboom, Ton, Buszman, Paweł, Bolognese, Leonardo, Tumscitz, Carlo, Bryniarski, Krzysztof, Aminian, Adel, Vrolix, Mathias, Petrov, Ivo, Garg, Scot, Naber, Christoph, Prokopczuk, Janusz, Hamm, Christian, Steg, Philippe Gabriel, Jüni, Peter, Windecker, Stephan, and Valgimigli, Marco

Published
2022
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149. Documento di consenso intersocietario ANMCO/ISS/AMD/ANCE/ARCA/FADOI/ GICR-IACPR/SICI-GISE/SIBioC/SIC/SICOA/ SID/SIF/SIMEU/SIMG/SIMI/SISA Colesterolo e rischio cardiovascolare: percorso diagnostico-terapeutico in Italia

Author

Gulizia, Michele Massimo, Colivicchi, Furio, Ricciardi, Gualtiero, Giampaoli, Simona, Maggioni, Aldo Pietro, Averna, Maurizio, Graziani, Maria Stella, Ceriotti, Ferruccio, Mugelli, Alessandro, Rossi, Francesco, Medea, Gerardo, Parretti, Damiano, Abrignani, Maurizio Giuseppe, Arca, Marcello, Filardi, Pasquale Perrone, Perticone, Francesco, Catapano, Alberico, Griffo, Raffaele, Nardi, Federico, Riccio, Carmine, Di Lenarda, Andrea, Scherillo, Marino, Musacchio, Nicoletta, Panno, Antonio Vittorio, Zito, Giovanni Battista, Campanini, Mauro, Bolognese, Leonardo, Faggiano, Pompilio Massimo, Musumeci, Giuseppe, Pusineri, Enrico, Ciaccio, Marcello, Bonora, Enzo, Cantelli Forti, Giorgio, Ruggieri, Maria Pia, Cricelli, Claudio, Romeo, Francesco, Ferrari, Roberto, Maseri, Attilio, Gulizia, Michele Massimo, Colivicchi, Furio, Ricciardi, Gualtiero, Giampaoli, Simona, Maggioni, Aldo Pietro, Averna, Maurizio, Graziani, Maria Stella, Ceriotti, Ferruccio, Mugelli, Alessandro, Rossi, Francesco, Medea, Gerardo, Parretti, Damiano, Abrignani, Maurizio Giuseppe, Arca, Marcello, Filardi, Pasquale Perrone, Perticone, Francesco, Catapano, Alberico, Griffo, Raffaele, Nardi, Federico, Riccio, Carmine, Di Lenarda, Andrea, Scherillo, Marino, Musacchio, Nicoletta, Panno, Antonio Vittorio, Zito, Giovanni Battista, Campanini, Mauro, Bolognese, Leonardo, Faggiano, Pompilio Massimo, Musumeci, Giuseppe, Pusineri, Enrico, Ciaccio, Marcello, Bonora, Enzo, Cantelli Forti, Giorgio, Ruggieri, Maria Pia, Cricelli, Claudio, Romeo, Francesco, Ferrari, Roberto, and Maseri, Attilio

Subjects
Settore BIO/12 - Biochimica Clinica E Biologia Molecolare Clinica, Settore MED/09 - Medicina Interna, Italy, Cardiovascular Disease, Risk Factor, Anticholesteremic Agent, Hypercholesterolemia, Settore BIO/14 - Farmacologia, Consensu, Cardiology and Cardiovascular Medicine, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Human
Abstract

Atherosclerotic cardiovascular disease still represents the leading cause of death in western countries. A wealth of scientific evidence demonstrates that increased blood cholesterol levels have a major impact on the outbreak and progression of atherosclerotic plaques. Moreover, several cholesterol-lowering pharmacological agents, including statins and ezetimibe, have proven effective in improving clinical outcomes. This document is focused on the clinical management of hypercholesterolemia and has been conceived by 16 Italian medical associations with the support of the Italian National Institute of Health. The authors have considered with particular attention the role of hypercholesterolemia in the genesis of atherosclerotic cardiovascular disease. Besides, the implications of high cholesterol levels in the definition of the individual cardiovascular risk profile have been carefully analyzed, while all available therapeutic options for blood cholesterol reduction and cardiovascular risk mitigation have been considered. Finally, this document outlines the diagnostic and therapeutic pathways for the clinical management of patients with hypercholesterolemia.

Published
2016

150. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Author

Roffi, Marco, Patrono, Carlo, Collet, Jean Philippe, Mueller, Christian, Valgimigli, Marco, Andreotti, Felicita, Bax, Jeroen J., Borger, Michael A., Brotons, Carlos, Chew, Derek P., Gencer, Baris, Hasenfuss, Gerd, Kjeldsen, Keld, Lancellotti, Patrizio, Landmesser, Ulf, Mehilli, Julinda, Mukherjee, Debabrata, Storey, Robert F., Windecker, Stephan, Zamorano, Jose Luis, Aboyans, Victor, Achenbach, Stephan, Agewall, Stefan, Badimon, Lina, Barón Esquivias, Gonzalo, Baumgartner, Helmut, Bueno, Héctor, Carerj, Scipione, Dean, Veronica, Erol, Çetin, Fitzsimons, Donna, Gaemperli, Oliver, Kirchhof, Paulus, Kolh, Philippe, Lip, Gregory Y. H., Nihoyannopoulos, Petros, Piepoli, Massimo F., Ponikowski, Piotr, Torbicki, Adam, Carneiro, Antonio Vaz, Chilingaryan, Aram, Weidinger, Franz, Najafov, Ruslan, Sinnaeve, Peter R., Terzić, Ibrahim, Postadzhiyan, Arman, Miličić, Davor, Eftychiou, Christos, Widimsky, Petr, Bang, Lia, El Etriby, Adel, Marandi, Toomas, Pietilä, Mikko, Kedev, Sasko, Koning, René, Aladashvili, Alexander, Neumann, Franz Josef, Tsioufis, Kostantinos, Becker, Dávid, Guðnason, Thorarinn, Matetzky, Shlomi, Bolognese, Leonardo, Mussagaliyeva, Aisulu, Beishenkulov, Medet, Latkovskis, Gustavs, Serpytis, Pranas, Pereira, Bruno, Magri, Caroline Jane, Grosu, Aurel, Abir Khalil, Saadia, Larsen, Alf Inge, Budaj, Andrzej, Mimoso, Jorge M. Vieira, Ginghina, Carmen, Averkov, Oleg, Nedeljkovic, Milan A., Studenčan, Martin, Barrabés, José A., Held, Claes, Rickli, Hans, Peters, Ron J. G., Mourali, Mohamed Sami, Atalar, Enver, Swanson, Neil, Parkhomenko, Alexander, Baigent, Colin, Casselman, Filip, Cuisset, Thomas, Halle, Martin, BUGIARDINI, RAFFAELE, Roffi, Marco, Patrono, Carlo, Collet, Jean-Philippe, Mueller, Christian, Valgimigli, Marco, Andreotti, Felicita, Bax, Jeroen J., Borger, Michael A., Brotons, Carlo, Chew, Derek P., Gencer, Bari, Hasenfuss, Gerd, Kjeldsen, Keld, Lancellotti, Patrizio, Landmesser, Ulf, Mehilli, Julinda, Mukherjee, Debabrata, Storey, Robert F., Windecker, Stephan, Zamorano, Jose Lui, Aboyans, Victor, Achenbach, Stephan, Agewall, Stefan, Badimon, Lina, Barón-Esquivias, Gonzalo, Baumgartner, Helmut, Bueno, Héctor, Carerj, Scipione, Dean, Veronica, Erol, Çetin, Fitzsimons, Donna, Gaemperli, Oliver, Kirchhof, Paulu, Kolh, Philippe, Lip, Gregory Y. H., Nihoyannopoulos, Petro, Piepoli, Massimo F., Ponikowski, Piotr, Torbicki, Adam, Carneiro, Antonio Vaz, Chilingaryan, Aram, Weidinger, Franz, Najafov, Ruslan, Sinnaeve, Peter R., Terzić, Ibrahim, Postadzhiyan, Arman, Miličić, Davor, Eftychiou, Christo, Widimsky, Petr, Bang, Lia, El Etriby, Adel, Marandi, Tooma, Pietilä, Mikko, Kedev, Sasko, Koning, René, Aladashvili, Alexander, Neumann, Franz-Josef, Tsioufis, Kostantino, Becker, Dávid, Guðnason, Thorarinn, Matetzky, Shlomi, Bolognese, Leonardo, Mussagaliyeva, Aisulu, Beishenkulov, Medet, Latkovskis, Gustav, Serpytis, Prana, Pereira, Bruno, Magri, Caroline Jane, Grosu, Aurel, Abir-Khalil, Saadia, Larsen, Alf Inge, Budaj, Andrzej, Mimoso, Jorge M. Vieira, Ginghina, Carmen, Averkov, Oleg, Nedeljkovic, Milan A., Studenčan, Martin, Barrabés, José A., Held, Clae, Rickli, Han, Peters, Ron J. G., Mourali, Mohamed Sami, Atalar, Enver, Swanson, Neil, Parkhomenko, Alexander, Baigent, Colin, Bugiardini, Raffaele, Casselman, Filip, Cuisset, Thoma, and Halle, Martin

Subjects
High-sensitivity troponin, Ticagrelor, Chest pain unit, Platelet inhibition, Glycoprotein IIb/IIIa inhibitor, Guideline, Myocardial ischaemia, Diabete, Nitrate, Early invasive strategy, Vorapaxar, Anticoagulation, Rivaroxaban, Stent, Apixaban, Beta-blocker, Enoxaparin, Bypass surgery, Rhythm monitoring, Aspirin, Heparin, Revascularization, Angioplasty, Atherothrombosi, Statin, Cangrelor, Acute cardiac care, Recommendation, Clopidogrel, Dabigatran, Fondaparinux, Acute coronary syndrome, Non-ST-elevation myocardial infarction, European society of cardiology, Cardiology and Cardiovascular Medicine, Bivalirudin, Prasugrel, Unstable angina
Abstract

N/A

Published
2016

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