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101. Reference of Plan Comparison Study for Liver-SBRT - Results DEGRO AG/DGMP AK Stereotaxis

Author

Moustakis, C., Blanck, O., Andratschke, N., Boda-Heggemann, J., Wilke, L., Tanadini-Lang, S., Albers, D., Alraun, M., Baeumer, C., Beckers, E., Blaschek, M., Brunner, T., Chan, M. K. H., Dierl, M., Droege, S., Duma, M-N., Ebrahimi, F., Eich, H. T., Fleckenstein, J., Ganswindt, U., Garbe, S., Gkika, E., Heinz, C., Henkenberens, C., Hennig, A., Henning, S., Koehn, J., Kornhuber, C., Kretschmer, M., Krieger, T., Loufti-Kraus, B., Mayr, M., Mensing, T., Pfeiler, T., Pollul, G., Ramm, U., Rieken, S., Roeder, F., Schmidthalter, D., Schmitt, D., Schoeffler, J., Ulm, C., Walke, M., Weigel, R., Wiehle, R., Wiezorek, T., Wolf, U., Zimmer, J., Baus, W., Guckenberger, M., Moustakis, C., Blanck, O., Andratschke, N., Boda-Heggemann, J., Wilke, L., Tanadini-Lang, S., Albers, D., Alraun, M., Baeumer, C., Beckers, E., Blaschek, M., Brunner, T., Chan, M. K. H., Dierl, M., Droege, S., Duma, M-N., Ebrahimi, F., Eich, H. T., Fleckenstein, J., Ganswindt, U., Garbe, S., Gkika, E., Heinz, C., Henkenberens, C., Hennig, A., Henning, S., Koehn, J., Kornhuber, C., Kretschmer, M., Krieger, T., Loufti-Kraus, B., Mayr, M., Mensing, T., Pfeiler, T., Pollul, G., Ramm, U., Rieken, S., Roeder, F., Schmidthalter, D., Schmitt, D., Schoeffler, J., Ulm, C., Walke, M., Weigel, R., Wiehle, R., Wiezorek, T., Wolf, U., Zimmer, J., Baus, W., and Guckenberger, M.

Published
2018

102. The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases

Author

Andratschke, N; https://orcid.org/0000-0003-3647-5916, Alheid, H, Allgäuer, M, Becker, G, Blanck, O, Boda-Heggemann, J, Brunner, T, Duma, M, Gerum, S, Guckenberger, M, Hildebrandt, G, Klement, R J, Lewitzki, V, Ostheimer, C, Papachristofilou, A, Petersen, C, Schneider, T, Semrau, R, Wachter, S, Habermehl, D, Andratschke, N; https://orcid.org/0000-0003-3647-5916, Alheid, H, Allgäuer, M, Becker, G, Blanck, O, Boda-Heggemann, J, Brunner, T, Duma, M, Gerum, S, Guckenberger, M, Hildebrandt, G, Klement, R J, Lewitzki, V, Ostheimer, C, Papachristofilou, A, Petersen, C, Schneider, T, Semrau, R, Wachter, S, and Habermehl, D

Abstract

BACKGROUND The intent of this pooled analysis as part of the German society for radiation oncology (DEGRO) stereotactic body radiotherapy (SBRT) initiative was to analyze the patterns of care of SBRT for liver oligometastases and to derive factors influencing treated metastases control and overall survival in a large patient cohort. METHODS From 17 German and Swiss centers, data on all patients treated for liver oligometastases with SBRT since its introduction in 1997 has been collected and entered into a centralized database. In addition to patient and tumor characteristics, data on immobilization, image guidance and motion management as well as dose prescription and fractionation has been gathered. Besides dose response and survival statistics, time trends of the aforementioned variables have been investigated. RESULTS In total, 474 patients with 623 liver oligometastases (median 1 lesion/patient; range 1–4) have been collected from 1997 until 2015. Predominant histologies were colorectal cancer (n = 213 pts.; 300 lesions) and breast cancer (n = 57; 81 lesions). All centers employed an SBRT specific setup. Initially, stereotactic coordinates and CT simulation were used for treatment set-up (55%), but eventually were replaced by CBCT guidance (28%) or more recently robotic tracking (17%). High variance in fraction (fx) number (median 1 fx; range 1–13) and dose per fraction (median: 18.5 Gy; range 3–37.5 Gy) was observed, although median BED remained consistently high after an initial learning curve. Median follow-up time was 15 months; median overall survival after SBRT was 24 months. One- and 2-year treated metastases control rate of treated lesions was 77% and 64%; if maximum isocenter biological equivalent dose (BED) was greater than 150 Gy EQD2Gy, it increased to 83% and 70%, respectively. Besides radiation dose colorectal and breast histology and motion management methods were associated with improved treated metastases control. CONCLUSION After an initial lea

Published
2018

103. OC-0523: SBRT for oligo-metastatic liver disease–effect of chemotherapy and histology on local tumor control

Author

Klement, R., primary, Guckenberger, M., additional, Alheid, H., additional, Allgaeuer, M., additional, Becker, G., additional, Blanck, O., additional, Boda-Hegemann, J., additional, Brunner, T., additional, Duma, M., additional, Gerum, S., additional, Habermehl, D., additional, Hildebrandt, G., additional, Lewitzki, V., additional, Ostheimer, C., additional, Papachristofilou, A., additional, Petersen, C., additional, Schneider, T., additional, Semrau, R., additional, Wachter, S., additional, and Andratschke, N., additional

Published
2017
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106. Stereotactic body radiotherapy for oligo-metastatic liver disease - Influence of pre-treatment chemotherapy and histology on local tumor control

Author

Klement, R. J., Guckenberger, M., Alheid, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Heggemann, J., Brunner, T., Duma, M., Gerum, S., Habermehl, D., Hildebrandt, G., Lewitzki, V., Ostheimer, C., Papachristofilou, A., Petersen, C., Schneider, T., Semrau, R., Wachter, S., Andratschke, N., Klement, R. J., Guckenberger, M., Alheid, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Heggemann, J., Brunner, T., Duma, M., Gerum, S., Habermehl, D., Hildebrandt, G., Lewitzki, V., Ostheimer, C., Papachristofilou, A., Petersen, C., Schneider, T., Semrau, R., Wachter, S., and Andratschke, N.

Abstract

Introduction:, Stereotactic body radiation therapy (SBRT) is applied in the oligometastatic setting to treat liver metastases. However, factors influencing tumor control probability (TCP) other than radiation dose have not been thoroughly investigated. Here we set out to investigate such factors with a focus on the influence of histology and chemotherapy prior to SBRT using a large multi-center database from the German Society of Radiation Oncology. Methods: 452 SBRT treatments in 363 patients were analyzed after collection of patient, tumor and treatment data in a multi-center database. Histology was considered through random effects in semi parametric and parametric frailty models. Dose prescriptions were parametrized by conversion to the maximum biologically effective dose using alpha/beta of 10 Gy (BEDmax). Results: After adjusting for histology, BEDmax was the strongest predictor of TCP. Larger PTV volumes, chemotherapy prior to SBRT and simple motion management techniques predicted significantly lower TCP. The model predicted a BED of 209 +/- 67 Gy(10) necessary for 90% TCP at 2 years with no prior chemotherapy, but 286 +/- 78 Gy(10) when chemotherapy had been given. Breast cancer metastases were significantly more responsive to SBRT compared to other histologies with 90% TCP at 2 years achievable with BED,. of 157 +/- 80 Gy(10) or 80 +/- 62 Gy(10) with and without prior chemotherapy, respectively. Conclusions: Besides dose, histology and pretreatment chemotherapy were important factors influencing local TCP in this large cohort of liver metastases. After adjusting for prior chemotherapy, our data add to the emerging evidence that breast cancer metastases do respond better to hypofractionated SBRT compared to other histologies. (C) 2017 Elsevier B.V. All rights reserved.

Published
2017

107. SBRT for oligo-metastatic liver disease-effect of chemotherapy and histology on local tumor control

Author

Klement, R., Guckenberger, M., Alheid, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Hegemann, J., Brunner, T., Duma, M., Gerum, S., Habermehl, D., Hildebrandt, G., Lewitzki, V., Ostheimer, C., Papachristofilou, A., Petersen, C., Schneider, T., Semrau, R., Wachter, S., Andratschke, N., Klement, R., Guckenberger, M., Alheid, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Hegemann, J., Brunner, T., Duma, M., Gerum, S., Habermehl, D., Hildebrandt, G., Lewitzki, V., Ostheimer, C., Papachristofilou, A., Petersen, C., Schneider, T., Semrau, R., Wachter, S., and Andratschke, N.

Published
2017

108. The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases

Author

Klement, R. J., Adebahr, S., Alheit, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Heggemann, J., Brunner, T., Duma, M., Eble, M. J., Ernst, I, Gerum, S., Habermehl, D., Hass, P., Henkenberens, C., Hildebrandt, G., Imhoff, D., Kahl, H., Klass, N. D., Krempien, R., Lewitzki, V, Lohaus, F., Ostheimer, C., Petersen, C., Papachristofilou, A., Rieber, J., Schneider, T., Schrade, E., Semrau, R., Teichgraeber, U., Wachter, S., Wittig, A., Guckenberger, M., Andratschke, N., Klement, R. J., Adebahr, S., Alheit, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Heggemann, J., Brunner, T., Duma, M., Eble, M. J., Ernst, I, Gerum, S., Habermehl, D., Hass, P., Henkenberens, C., Hildebrandt, G., Imhoff, D., Kahl, H., Klass, N. D., Krempien, R., Lewitzki, V, Lohaus, F., Ostheimer, C., Petersen, C., Papachristofilou, A., Rieber, J., Schneider, T., Schrade, E., Semrau, R., Teichgraeber, U., Wachter, S., Wittig, A., Guckenberger, M., and Andratschke, N.

Published
2017

109. Patterns of care and outcome analysis of SBRT for colorectal lung and liver metastases in 388 patients with 500 metastases: an analysis of the DEGRO working group Stereotactic Radiotherapy

Author

Basler, L., Adebahr, S., Alheit, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Heggemann, J., Brunner, T., Duma, M., Eble, M. J., Ernst, I, Gerum, S., Habermehl, D., Hass, P., Henkenberens, C., Hildebrandt, G., Imhoff, D., Kahl, H., Klass, N. D., Klement, R. J., Krempien, R., Lewitzki, V, Lohaus, F., Ostheimer, C., Petersen, C., Papachristofilou, A., Rieber, J., Schneider, T., Schrade, E., Semrau, R., Teichgraeber, U., Wachter, S., Wittig, A., Guckenberger, M., Andratschke, N., Basler, L., Adebahr, S., Alheit, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Heggemann, J., Brunner, T., Duma, M., Eble, M. J., Ernst, I, Gerum, S., Habermehl, D., Hass, P., Henkenberens, C., Hildebrandt, G., Imhoff, D., Kahl, H., Klass, N. D., Klement, R. J., Krempien, R., Lewitzki, V, Lohaus, F., Ostheimer, C., Petersen, C., Papachristofilou, A., Rieber, J., Schneider, T., Schrade, E., Semrau, R., Teichgraeber, U., Wachter, S., Wittig, A., Guckenberger, M., and Andratschke, N.

Published
2017

111. Radiotherapy beyond cancer: target localization in real-time MRI and treatment planning for cardiac radiosurgery

Author

Ipsen, S, Blanck, O, Oborn, B, Bode, F, Liney, G, Hunold, P, Rades, D, Schweikard, A, and Keall, P

Subjects
real-time tracking, cardiac radiosurgery, image guidance, MRI-Linac, Atrial fibrillation
Abstract

PURPOSE: Atrial fibrillation (AFib) is the most common cardiac arrhythmia that affects millions of patients world-wide. AFib is usually treated with minimally invasive, time consuming catheter ablation techniques. While recently noninvasive radiosurgery to the pulmonary vein antrum (PVA) in the left atrium has been proposed for AFib treatment, precise target location during treatment is challenging due to complex respiratory and cardiac motion. A MRI linear accelerator (MRI-Linac) could solve the problems of motion tracking and compensation using real-time image guidance. In this study, the authors quantified target motion ranges on cardiac magnetic resonance imaging (MRI) and analyzed the dosimetric benefits of margin reduction assuming real-time motion compensation was applied. METHODS: For the imaging study, six human subjects underwent real-time cardiac MRI under free breathing. The target motion was analyzed retrospectively using a template matching algorithm. The planning study was conducted on a CT of an AFib patient with a centrally located esophagus undergoing catheter ablation, representing an ideal case for cardiac radiosurgery. The target definition was similar to the ablation lesions at the PVA created during catheter treatment. Safety margins of 0 mm (perfect tracking) to 8 mm (untracked respiratory motion) were added to the target, defining the planning target volume (PTV). For each margin, a 30 Gy single fraction IMRT plan was generated. Additionally, the influence of 1 and 3 T magnetic fields on the treatment beam delivery was simulated using Monte Carlo calculations to determine the dosimetric impact of MRI guidance for two different Linac positions. RESULTS: Real-time cardiac MRI showed mean respiratory target motion of 10.2 mm (superior-inferior), 2.4 mm (anterior-posterior), and 2 mm (left-right). The planning study showed that increasing safety margins to encompass untracked respiratory motion leads to overlapping structures even in the ideal scenario, compromising either normal tissue dose constraints or PTV coverage. The magnetic field caused a slight increase in the PTV dose with the in-line MRI-Linac configuration. CONCLUSIONS: The authors' results indicate that real-time tracking and motion compensation are mandatory for cardiac radiosurgery and MRI-guidance is feasible, opening the possibility of treating cardiac arrhythmia patients completely noninvasively.

Published
2014

112. Patterns of care and outcome analysis of SBRT for liver metastases - a DEGRO database initiative

Author

Andratschke, N., Alheid, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Hegemann, J., Brunner, T., Combs, S., Duma, M., Gerum, S., Guckenberger, M., Hildebrandt, G., Ostheimer, C., Panje, C., Papachristofilou, A., Petersen, C., Schneider, T., Semrau, R., Wachter, S., Habermehl, D., Andratschke, N., Alheid, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Hegemann, J., Brunner, T., Combs, S., Duma, M., Gerum, S., Guckenberger, M., Hildebrandt, G., Ostheimer, C., Panje, C., Papachristofilou, A., Petersen, C., Schneider, T., Semrau, R., Wachter, S., and Habermehl, D.

Published
2016

115. OC-0445: Patterns of care and outcome analysis of SBRT for liver metastases - a DEGRO database initiative

Author

Andratschke, N., primary, Alheid, H., additional, Allgäuer, M., additional, Becker, G., additional, Blanck, O., additional, Boda-Hegemann, J., additional, Brunner, T., additional, Combs, S., additional, Duma, M., additional, Gerum, S., additional, Guckenberger, M., additional, Hildebrandt, G., additional, Ostheimer, C., additional, Panje, C., additional, Papachristofilou, A., additional, Petersen, C., additional, Schneider, T., additional, Semrau, R., additional, Wachter, S., additional, and Habermehl, D., additional

Published
2016
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117. Matched pair analysis of mask-based and mask-less radiosurgery for benign intracranial tumors

Author

Blanck, O, Seifert, S, Rasche, D, Rades, D, Hildebrandt, G, and Tronnier, V

Subjects
ddc: 610, CyberKnife, mask-less, 610 Medical sciences, Medicine, Radiochirurgie, Radiosurgery, masken-los
Abstract

Objective: To precisely guide the high dose beams during radiosurgery for intracranial tumors two methodologies exist: A stereotactic frame which is attached to the patients’ skull as coordinate system (GammaKnife™, Elekta, Sweden) and x-ray image guidance with immobilization devices such[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Published
2012
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119. Results of NSCLC Planning Comparative Study of DEGRO AG Stereotaxy

Author

Moustakis, C., Ernst, I, Kittel, C., Krieger, T., Duma, M. N., Oechsner, M., Ganswindt, U., Heinz, C., Alheit, H., Blank, H., Nestle, U., Wiehle, R., Kornhuber, C., Ostheimer, C., Petersen, C., Gauer, T., Pollul, G., Baus, W., Altenstein, G., Blanck, O., Beckers, E., Sterzing, F., Kretschmer, M., Seegenschmiedt, M. H., Maass, T., Droege, S., Wolf, U., Schoeffler, J., Thiele, M., Ebrahimi, F., Guckenberger, M., Moustakis, C., Ernst, I, Kittel, C., Krieger, T., Duma, M. N., Oechsner, M., Ganswindt, U., Heinz, C., Alheit, H., Blank, H., Nestle, U., Wiehle, R., Kornhuber, C., Ostheimer, C., Petersen, C., Gauer, T., Pollul, G., Baus, W., Altenstein, G., Blanck, O., Beckers, E., Sterzing, F., Kretschmer, M., Seegenschmiedt, M. H., Maass, T., Droege, S., Wolf, U., Schoeffler, J., Thiele, M., Ebrahimi, F., and Guckenberger, M.

Published
2015

120. Results of the Planning Comparison Study SBRT of NSCLC

Author

Moustakis, C., Ernst, I., Kittel, C., Eich, H., Krieger, T., Duma, M., Oechsner, M., Ganswindt, U., Heinz, C., Alheit, H., Blank, H., Nestle, U., Wiehle, R., Kornhuber, C., Ostheimer, C., Petersen, C., Albers, D., Pollul, G., Baus, W. W., Altenstein, G., Blanck, O., Beckers, E., Sterzing, F., Kretschmer, M., Seegenschmiedt, H., Maass, T., Droege, S., Wolf, U., Schoeffler, J., Thiele, M., Ciernik, I. F., Ebrahimi, F., Guckenberger, M., Moustakis, C., Ernst, I., Kittel, C., Eich, H., Krieger, T., Duma, M., Oechsner, M., Ganswindt, U., Heinz, C., Alheit, H., Blank, H., Nestle, U., Wiehle, R., Kornhuber, C., Ostheimer, C., Petersen, C., Albers, D., Pollul, G., Baus, W. W., Altenstein, G., Blanck, O., Beckers, E., Sterzing, F., Kretschmer, M., Seegenschmiedt, H., Maass, T., Droege, S., Wolf, U., Schoeffler, J., Thiele, M., Ciernik, I. F., Ebrahimi, F., and Guckenberger, M.

Published
2015

121. Results of the Planning Comparison Study SBRT of NSCLC

Author

Moustakis, C., primary, Ernst, I., additional, Kittel, C., additional, Eich, H., additional, Krieger, T., additional, Duma, M., additional, Oechsner, M., additional, Ganswindt, U., additional, Heinz, C., additional, Alheit, H., additional, Blank, H., additional, Nestle, U., additional, Wiehle, R., additional, Kornhuber, C., additional, Ostheimer, C., additional, Petersen, C., additional, Albers, D., additional, Pollul, G., additional, Baus, W.W., additional, Altenstein, G., additional, Blanck, O., additional, Beckers, E., additional, Sterzing, F., additional, Kretschmer, M., additional, Seegenschmiedt, H., additional, Maass, T., additional, Droege, S., additional, Wolf, U., additional, Schoeffler, J., additional, Thiele, M., additional, Ciernik, I.F., additional, Ebrahimi, F., additional, and Guckenberger, M., additional

Published
2015
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122. TH-AB-303-01: Benchmarking Real-Time Adaptive Radiotherapy Systems: A Multi- Platform Multi-Institutional Study

Author

Colvill, E, primary, Booth, J, additional, Nill, S, additional, Fast, M, additional, Bedford, J, additional, Oelfke, U, additional, Nakamura, M, additional, Poulsen, P, additional, Hansen, R, additional, Worm, E, additional, Ravkilde, T, additional, Rydhoeg, J Scherman, additional, Pommer, T, additional, Munck Af Rosenschoeld, P, additional, Lang, S, additional, Guckenberger, M, additional, Groh, C, additional, Herrmann, C, additional, Verellen, D, additional, Poels, K, additional, Wang, L, additional, Hadsell, M, additional, Blanck, O, additional, Sothmann, T, additional, and Keall, P, additional

Published
2015
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127. Predictive toxicology: the paths of the future

Author

Detilleux, Ph, Vallier, L, Legallais, C, Leclerc, E, Prot J, M, Choucha, L, Baudoin, R, Dufresne, M, Gautier, A, Carpentier, B, Mansuy, D, Pery, Alexandre R.R., Brochot, C, Manivet, Ph, Rabilloud, Thierry, Spire, C, Coumoul, Xavier, Junot, Ch, Laprevote, O, Le Pape, A, Tourneur, E, Ben Mkaddem, S, Chassin, C, Aloulou, M, Goujon J, M, Hertif, A, Ouali, N, Vimont, S, Monteiro, R, Rondeau, E, Elbim, C, Werts, C, Vandewalle, A, Pedruzzi, E, Coant, N, Bens, M, Cluzeaud, F, Ogier-Denis, E, Pongnimitprasert, N, Babin-Chevaye, C, Fay, M, Bernard, M, Dupuy, C, Ei Benna, J, Gougerot-Pocidale M, A, Braut-Boucher, F, Pinton, Philippe, Lucioli, Joelma, Tsybulskyy, D, Joly, Baptiste, Laffitte, J, Bourges-Abella, N, Oswald, Isabelle P., Kolf-Clauw, Martine, Pierre, St, Bats A, S, Chevalier, Aline, Bui L, Ch, Ambolet-Camoit, A, Garlatti, M, Aggerbeck, M, Barouki, R, Al Khansa, I, Blanck, O, Guillouzo, A, Bars, R, Rouas, C, Bensoussan, H, Suhard, D, Tessier, C, Grandcolas, L, Pallardy, M, Gueguen, Y, Sparfel, L, Pinel-Marie M, L, Boize, M, Koscielny, S, Desmots, S, Fardel, O, Alvergnas, M, Rouleau, A, Lucchi, G, Mantion, G, Heyd, B, Richert, L, Ducoroy, P, Martin, H, Val, St, Martinon, L, Cachier, H, Yahyaoui, A, Marfaing, H, Baeza-Squiban, A, Martin-Chouly, Corinne, Bonvallet, M, Morzadec, C, Vernhet, L, Baverel, G, El Hage, M, Nazaret, R, Conjard-Duplany, A, Ferrier, B, Martin, G, Legendre, A, Lecomte, Anthony, Froment, P, Habert, R, Lemazurier, E, Robinel, F, Dupont, O, Sanfins, E, Dairou, J, Chaffotte A, F, Busi, F, Rodrigues Lima, F, Dupret J, M, Mayati, A, Le Ferrec, Eric, Levoin, N, Paris, H, Uriac, Ph, N'Diaye, M, Lagadic-Gossmann, D, Assemat, E, Boublil, L, Borot M, C, Marano, F, Martiny V, Y, Moroy, G, Badel, A, Miteva M, A, Hussain, S, Ferecatu, I, Borot, C, Andreau, K, Boland, S, Leroux, M, Zucchini-Pascal, Nathalie, Peyre, L, Rahmani, Roger, Buron, N, Porcedou, M, Fromenty, B, Borgne-Sanchez, A, Rogue, A, Claude, N, Le Guével, Rémy, Institut National de l'Environnement Industriel et des Risques (INERIS), Laboratoire pharmaceutique Biologie Servier, Biologie Servier, Pharmacologie, toxicologie et signalisation cellulaire (U747), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine Xavier Bichat, Centre de recherche biomédicale Bichat-Beaujon (CRB3), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de recherche Pharmacologie-Toxicologie (UPT), Institut National de la Recherche Agronomique (INRA), Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Cytokines, chimiokines et immunopathologie, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Fonctions et dysfonctions épithéliales - UFC (EA 4267) (FDE), Université de Franche-Comté (UFC), Plate-forme Protéomique CLIPP - Clinical and Innovation Proteomic Platform [Dijon] (CLIPP), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM)-Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Cellules Souches et Radiations (SCSR (U967 / UMR-E_008)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Sud - Paris 11 (UP11), Laboratoire Bioprojet, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes-Centre National de la Recherche Scientifique (CNRS), Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Mitologics SAS, Hôpital Robert Debré, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de radiotoxicologie expérimentale (IRSN/DRPH/SRBE/LRTOX), Service de RadioBiologie et d'Epidémiologie (IRSN/DRPH/SRBE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Stabilité génétique, Cellules Souches et Radiations (SCSR (U_967)), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Université Paris-Sud - Paris 11 (UP11)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Rennes-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), Institut National de l'Environnement Industriel et des Risques ( INERIS ), Physiologie Cellulaire des Regulations Hormonales, Nutritionnelles et Pharmacologiques, Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de recherche biomédicale Bichat-Beaujon ( CRB3 ), Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité de recherche Pharmacologie-Toxicologie ( UPT ), Institut National de la Recherche Agronomique ( INRA ), Toxicologie, Pharmacologie et Signalisation Cellulaire ( U1124 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de biostatistique et d'épidémiologie ( SBE ), Institut Gustave Roussy ( IGR ) -Institut Gustave Roussy ( IGR ), Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), Fonctions et dysfonctions épithéliales - UFC (EA 4267) ( FDE ), Université de Franche-Comté ( UFC ), Plate-forme Protéomique CLIPP - Clinical and Innovation Proteomic Platform [Dijon] ( CLIPP ), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) ( FEMTO-ST ), Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Université de Technologie de Belfort-Montbeliard ( UTBM ) -Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Université de Technologie de Belfort-Montbeliard ( UTBM ) -Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] ( ICMUB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ( LSCE ), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Centre National de la Recherche Scientifique ( CNRS ), Cellules Souches et Radiations ( SCSR - U 967 ), Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut des Sciences Chimiques de Rennes ( ISCR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Ecole Nationale Supérieure de Chimie de Rennes-Institut National des Sciences Appliquées ( INSA ) -Centre National de la Recherche Scientifique ( CNRS ), Biologie Fonctionnelle et Adaptative ( BFA ), and Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
[ SDV ] Life Sciences [q-bio], [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2010

129. Toxicologie predictive: les voies du futur

Author

Ph Detilleux, Vallier, L., Legallais, C., Leclerc, E., M Prot J, Choucha, L., Baudoin, R., Dufresne, M., Gautier, A., Carpentier, B., Mansuy, D., Pery, Alexandre R. R., Brochot, C., Ph Manivet, Thierry Rabilloud, Spire, C., Xavier Coumoul, Ch Junot, Laprevote, O., Le Pape, A., Ronan Le Guével, Tourneur, E., Ben Mkaddem, S., Chassin, C., Aloulou, M., M Goujon J, Hertif, A., Ouali, N., Vimont, S., Monteiro, R., Rondeau, E., Elbim, C., Werts, C., Vandewalle, A., Pedruzzi, E., Coant, N., Bens, M., Cluzeaud, F., Ogier-Denis, E., Pongnimitprasert, N., Babin-Chevaye, C., Fay, M., Bernard Fromenty, Dupuy, C., Ei Benna, J., A Gougerot-Pocidale M, Braut-Boucher, F., Ph Pinton, Lucioli, J., Tsybulskyy, D., Baptiste Joly, Laffitte, J., Bourges-Abella, N., P Oswald I, Kolf-Clauw, M., St Pierre, S Bats A, Aline Chevalier, Ch Bui L, Ambolet-Camoit, A., Garlatti, M., Aggerbeck, M., Barouki, R., Al Khansa, I., Blanck, O., Guillouzo, A., Bars, R., Rouas, C., Bensoussan, H., Suhard, D., Tessier, C., Grandcolas, L., Pallardy, M., Gueguen, Y., Sparfel, L., L Pinel-Marie M, Boize, M., Koscielny, S., Desmots, S., Fardel, O., Alvergnas, M., Rouleau, A., Lucchi, G., Mantion, G., Heyd, B., Richert, L., Ducoroy, P., Martin, H., St Val, Martinon, L., Cachier, H., Yahyaoui, A., Marfaing, H., Baeza-Squiban, A., Corinne Martin-Chouly, Bonvallet, M., Morzadec, C., Vernhet, L., Baverel, G., El Hage, M., Nazaret, R., Conjard-Duplany, A., Ferrier, B., Martin, G., Legendre, A., Lecomte, A., Froment, P., Habert, R., Lemazurier, E., Robinel, F., Dupont, O., Sanfins, E., Dairou, J., F Chaffotte A, Busi, F., Rodrigues Lima, F., M Dupret J, Mayati, A., Eric Le Ferrec, Levoin, N., Paris, H., Ph Uriac, Diaye, M. N., Lagadic-Gossmann, D., Assemat, E., Boublil, L., C Borot M, Marano, F., Y Martiny V, Moroy, G., Badel, A., A Miteva M, Hussain, S., Ferecatu, I., Borot, C., Andreau, K., Boland, S., Leroux, M., Zucchini-Pascal, N., Peyre, L., Rahmani, R., Buron, N., Porcedou, M., Fromenty, B., Borgne-Sanchez, A., Rogue, A., Claude, N., and Jonchère, Laurent

Subjects
[SDV] Life Sciences [q-bio], [SDV.TOX] Life Sciences [q-bio]/Toxicology
Published
2010

130. Radiosurgery: identification of efficient treatment beams guided by autostereoscopic visualization

Author

Schlaefer, A, Blanck, O, Shiomi, H, and Schweikard, A

Subjects
robotics, ddc: 610, auto-stereoscopic visualization, radiosurgery, inverse planning
Abstract

In robotic radiosurgery, an arrangement of cylindrical beams forms a high dose area conformal to the target region. Beams start at various positions around the patient, and are oriented towards arbitrary points in the target. Due to the large number of potential beams, only a small subset of beams can be considered during treatment planning. An efficient heuristics to select promising candidate beams can substantially shorten and improve treatment planning. We have developed a tool to visualize the 3D dose distribution and the beams. Using a hypsometric color scheme, the visualization toolkit (VTK), and an autostereoscopic display, we established the spatial extent of cold and hot spots and the effect of beams.With this new visualization tool we assessed the dose distribution and the beam arrangement of two treatment plans for intra-cranial tumors. Based on the visual analysis of the dose distribution and the effect of the beams, we derived a heuristics to place beams. Treatment plans computed for the heuristically placed beams were compared to the original plans. The results suggest that a heuristic pre-selection of potential treatment beams is possible.The visualization proved useful for 3D analysis of treatment plans and as a tool for rapid development of beam placement heuristics.

Published
2006

131. Extra Cranial stereotactical Radiotherapy (ESRT) with primary and secondary Liver Tumors-first Results with > 650 Patients of the DEGRO AG Stereotaxy

Author

Ernst, I, Andratschke, N., Brunner, T., Blanck, O., Habermehl, D., Papachristofilou, A., Allgaeuer, M., Gauer, T., Petersen, C., Wachter, S., Semrau, R., Kornhuber, C., Ostheimer, C., Gerum, S., Seegenschmiedt, H., Schneider, T., Lubinski-de Lange, G., Alheit, H., Moustakis, C., Guckenberger, M., Ernst, I, Andratschke, N., Brunner, T., Blanck, O., Habermehl, D., Papachristofilou, A., Allgaeuer, M., Gauer, T., Petersen, C., Wachter, S., Semrau, R., Kornhuber, C., Ostheimer, C., Gerum, S., Seegenschmiedt, H., Schneider, T., Lubinski-de Lange, G., Alheit, H., Moustakis, C., and Guckenberger, M.

Published
2014

133. SBRT for Lung Metastases: A Pooled Analysis of 651 Patients and 868 Lesions of the German Working Group Stereotactic Radiotherapy

Author

Sterzing, F., primary, Streblow, J., additional, Scherer, K., additional, Adebahr, S., additional, Adratschke, N., additional, Boda-Heggemann, J., additional, Blanck, O., additional, Duma, M., additional, Ernst, I., additional, Gademann, G., additional, Ganswindt, U., additional, Henkenberens, C., additional, Imhoff, D., additional, Kahl, H., additional, Lohaus, F., additional, Lubinski-de Lange, G., additional, Maertin, A., additional, Petersen, C., additional, Wittig, A., additional, and Guckenberger, M., additional

Published
2014
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