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102. FEV1 is a stronger mortality predictor than FVC in patients with moderate COPD and with an increased risk for cardiovascular disease

Author

Bikov, Andras, primary, Lange, Peter, additional, Anderson, Julie A, additional, Brook, Robert D, additional, Calverley, Peter MA, additional, Celli, Bartolome R, additional, Cowans, Nicholas J, additional, Crim, Courtney, additional, Dixon, Ian J, additional, Martinez, Fernando J, additional, Newby, David E, additional, Yates, Julie C, additional, and Vestbo, Jørgen, additional

Published
2020
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109. Research highlights from the 2018 European Respiratory Society International Congress: Airway disease

Author

Schleich, Florence, Bikov, Andras, Mathioudakis, Alexander G., McDonnell, Melissa, Andersson, Cecilia, Bonini, Matteo, Uller, Lena, Idzko, Marco, Singh, Dave, López-Campos, J. L., Bossios, Apostolos, Adcock, Ian M., Usmani, Omar, Spanevello, Antonio, Bonvini, Sara J., Schleich, Florence, Bikov, Andras, Mathioudakis, Alexander G., McDonnell, Melissa, Andersson, Cecilia, Bonini, Matteo, Uller, Lena, Idzko, Marco, Singh, Dave, López-Campos, J. L., Bossios, Apostolos, Adcock, Ian M., Usmani, Omar, Spanevello, Antonio, and Bonvini, Sara J.

Abstract

The annual European Respiratory Society (ERS) International Congress (held in Paris in 2018) was once again a platform for discussion of the highest-quality scientific research, cutting-edge techniques and innovative new therapies within the respiratory field. This article discusses only some of the high-quality research studies presented at this year's Congress, with a particular focus on airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis and cough, as presented through Assembly 5 of the ERS (Airway Diseases: Asthma and COPD). The authors establish the key take-home messages of these studies, compare their findings and place them in the context of current understanding.

Published
2019

115. Comprehensive coronary plaque assessment in patients with obstructive sleep apnea

Author

Bikov, Andras, primary, Kolossváry, Márton, additional, Jermendy, Adam L., additional, Drobni, Zsofia D., additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Forgó, Bianka, additional, Kovacs, Daniel T., additional, Losonczy, Gyorgy, additional, Kunos, Laszlo, additional, Voros, Szilard, additional, Merkely, Bela, additional, and Maurovich‐Horvat, Pal, additional

Published
2019
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116. Research highlights from the 2018 European Respiratory Society International Congress: airway disease

Author

Schleich, Florence, primary, Bikov, Andras, additional, Mathioudakis, Alexander G., additional, McDonnell, Melissa, additional, Andersson, Cecilia, additional, Bonini, Matteo, additional, Uller, Lena, additional, Idzko, Marco, additional, Singh, Dave, additional, Lopez-Campos, Jose Luis, additional, Bossios, Apostolos, additional, Adcock, Ian M., additional, Usmani, Omar, additional, Spanevello, Antonio, additional, and Bonvini, Sara J., additional

Published
2019
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117. Juniors’ voice at the ERS International Congress, Amsterdam 2015

Author

Polverino, Francesca, Longhini, Federico, Vanaudenaerde, Bart, Bikov, Andras, Aamli, Ane, Singanayagam, Aran, Kahn, Nicolas, Boots, Agnes, and Skoczynski, Szymon

Subjects
lcsh:RC705-779, education, lcsh:Diseases of the respiratory system, Expert Opinion
Abstract

This year’s ERS International Congress was, as always, well-organised, providing participants with a good mixture of translational and clinical science. The emerging trend throughout the conference was the personalised approach, dedicated to better understanding, characterising and thus managing patients as individuals with unique combinations of clinical characteristics rather than as a single diagnostic entity., The Juniors’ voice at the ERS International Congress http://ow.ly/ULcej

Published
2015

125. A European Respiratory Society technical standard : exhaled biomarkers in lung disease

Author

Horváth, Ildiko, Barnes, Peter J., Loukides, Stelios, Sterk, Peter J., Högman, Marieann, Olin, Anna-Carin, Amann, Anton, Antus, Balazs, Baraldi, Eugenio, Bikov, Andras, Boots, Agnes W., Bos, Lieuwe D., Brinkman, Paul, Bucca, Caterina, Carpagnano, Giovanna E., Corradi, Massimo, Cristescu, Simona, de Jongste, Johan C., Dinh-Xuan, Anh-Tuan, Dompeling, Edward, Fens, Niki, Fowler, Stephen, Hohlfeld, Jens M., Holz, Olaf, Jobsis, Quirijn, Van De Kant, Kim, Knobel, Hugo H., Kostikas, Konstantinos, Lehtimaki, Lauri, Lundberg, Jon, Montuschi, Paolo, Van Muylem, Alain, Pennazza, Giorgio, Reinhold, Petra, Ricciardolo, Fabio L. M., Rosias, Philippe, Santonico, Marco, van der Schee, Marc P., van Schooten, Frederik-Jan, Spanevello, Antonio, Tonia, Thomy, Vink, Teunis J., Horváth, Ildiko, Barnes, Peter J., Loukides, Stelios, Sterk, Peter J., Högman, Marieann, Olin, Anna-Carin, Amann, Anton, Antus, Balazs, Baraldi, Eugenio, Bikov, Andras, Boots, Agnes W., Bos, Lieuwe D., Brinkman, Paul, Bucca, Caterina, Carpagnano, Giovanna E., Corradi, Massimo, Cristescu, Simona, de Jongste, Johan C., Dinh-Xuan, Anh-Tuan, Dompeling, Edward, Fens, Niki, Fowler, Stephen, Hohlfeld, Jens M., Holz, Olaf, Jobsis, Quirijn, Van De Kant, Kim, Knobel, Hugo H., Kostikas, Konstantinos, Lehtimaki, Lauri, Lundberg, Jon, Montuschi, Paolo, Van Muylem, Alain, Pennazza, Giorgio, Reinhold, Petra, Ricciardolo, Fabio L. M., Rosias, Philippe, Santonico, Marco, van der Schee, Marc P., van Schooten, Frederik-Jan, Spanevello, Antonio, Tonia, Thomy, and Vink, Teunis J.

Abstract

Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management. Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members. Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised. Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.

Published
2017
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126. Genetic relationship between obstructive sleep apnea and lumbar disc degeneration: results from a twin study

Author

Tárnoki, Ádám Domonkos, primary, Tarnoki, David Laszlo, additional, Kovacs, Daniel Tamas, additional, Forgo, Bianka, additional, Szily, Marcell, additional, Pinheiro, Marina De Barros, additional, Ferreira, Paulo, additional, Kostyal, Laszlo, additional, Olah, Csaba, additional, Kunos, Laszlo, additional, and Bikov, Andras, additional

Published
2017
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127. A European Respiratory Society technical standard: exhaled biomarkers in lung disease

Author

Horváth, Ildiko, primary, Barnes, Peter J., additional, Loukides, Stelios, additional, Sterk, Peter J., additional, Högman, Marieann, additional, Olin, Anna-Carin, additional, Amann, Anton, additional, Antus, Balazs, additional, Baraldi, Eugenio, additional, Bikov, Andras, additional, Boots, Agnes W., additional, Bos, Lieuwe D., additional, Brinkman, Paul, additional, Bucca, Caterina, additional, Carpagnano, Giovanna E., additional, Corradi, Massimo, additional, Cristescu, Simona, additional, de Jongste, Johan C., additional, Dinh-Xuan, Anh-Tuan, additional, Dompeling, Edward, additional, Fens, Niki, additional, Fowler, Stephen, additional, Hohlfeld, Jens M., additional, Holz, Olaf, additional, Jöbsis, Quirijn, additional, Van De Kant, Kim, additional, Knobel, Hugo H., additional, Kostikas, Konstantinos, additional, Lehtimäki, Lauri, additional, Lundberg, Jon O., additional, Montuschi, Paolo, additional, Van Muylem, Alain, additional, Pennazza, Giorgio, additional, Reinhold, Petra, additional, Ricciardolo, Fabio L.M., additional, Rosias, Philippe, additional, Santonico, Marco, additional, van der Schee, Marc P., additional, van Schooten, Frederik-Jan, additional, Spanevello, Antonio, additional, Tonia, Thomy, additional, and Vink, Teunis J., additional

Published
2017
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133. Comparison of classification methods in breath analysis by electronic nose

Author

Leopold, Jan Hendrik, primary, Bos, Lieuwe D J, additional, Sterk, Peter J, additional, Schultz, Marcus J, additional, Fens, Niki, additional, Horvath, Ildiko, additional, Bikov, Andras, additional, Montuschi, Paolo, additional, Di Natale, Corrado, additional, Yates, Deborah H, additional, and Abu-Hanna, Ameen, additional

Published
2015
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146. Research highlights from the 2018 European Respiratory Society International Congress: Airway disease

Author

Universidad de Sevilla. Departamento de Medicina, Schleich, Florence, Bikov, Andras, Mathioudakis, Alexander G., McDonnell, Melissa, Andersson, Cecilia, Lopez-Campos Bodineau, Jose Luis, Bonvini, Sara J., Universidad de Sevilla. Departamento de Medicina, Schleich, Florence, Bikov, Andras, Mathioudakis, Alexander G., McDonnell, Melissa, Andersson, Cecilia, Lopez-Campos Bodineau, Jose Luis, and Bonvini, Sara J.

Abstract

The annual European Respiratory Society (ERS) International Congress (held in Paris in 2018) was once again a platform for discussion of the highest-quality scientific research, cutting-edge techniques and innovative new therapies within the respiratory field. This article discusses only some of the high-quality research studies presented at this year’s Congress, with a particular focus on airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis and cough, as presented through Assembly 5 of the ERS (Airway Diseases: Asthma and COPD). The authors establish the key take-home messages of these studies, compare their findings and place them in the context of current understanding.

Published
2010

149. Exhaled breath analysis, a simple tool to study the pathophysiology of obstructive sleep apnoea.

Author

Bikov, Andras, Hull, James H, and Kunos, Laszlo

Abstract

Accelerated airway inflammation may play a crucial role in the pathophysiology of obstructive sleep apnoea (OSA); however this phenomenon has been investigated only in a limited number of studies. The analysis of exhaled breath represents a promising, non-invasive tool to evaluate airway inflammation in this context. The knowledge on exhaled biomarkers in OSA has been growing with an emerging number of methodological studies which help to interpret exhaled breath data. This article not only summarises the results of studies on exhaled breath condensate (EBC) biomarkers, exhaled volatile compounds and exhaled monoxides in OSA, but also aims to critically review methodological limitations and provide some guideline for further research. [ABSTRACT FROM AUTHOR]

Published
2016
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150. The role of impulse oscillometry in detecting airway dysfunction in athletes.

Author

Price, Oliver J., Ansley, Les, Bikov, Andras, and Hull, James H.

Subjects
ASTHMA diagnosis, OSCILLOMETER, AIRWAY (Anatomy), SPIROMETRY, ATHLETES' health
Abstract

Background: Impulse oscillometry (IOS) has previously been proposed to provide greater sensitivity than spirometry when employed with indirect bronchoprovocation testing for the diagnosis of airway dysfunction in athletes. However, this recommendation is based on a highly selected population of symptomatic patients.Objective: To compare IOS, spirometry and respiratory symptoms following indirect bronchoprovocation in a screened cohort of athletes.Methods: One hundred and one recreational athletes were recruited. Respiratory symptoms were assessed via the Dyspnoea-12 questionnaire. Spirometry and IOS were performed pre and post a eucapnic voluntary hyperpnoea (EVH) challenge.Results: Ninety-four athletes completed the study. Sixteen athletes (17%) were positive for airway dysfunction based on spirometry (i.e. ≥10% fall in FEV1) and 17 athletes (18%) based on IOS (i.e. ≥50% increase in R5). Only nine athletes (10%) met both diagnostic thresholds. A poor relationship was observed between respiratory symptoms (i.e. Dyspnoea-12 score) and all spirometry and IOS variables. A direct relationship was observed between percentage change in R5(r = 0.65), Z5(r = 0.68), RF(r = 0.65), AX(r = 0.69) and the maximum fall in FEV1(ΔFEV1max;p < 0.001). A weak relationship was observed between R20(r = 0.27), X5(r = 0.37) and ΔFEV1max (p < 0.01).Conclusion: Impulse oscillometry and spirometry do not concur precisely following indirect bronchoprovocation. However, IOS detects additional cases of airway dysfunction in athletes and therefore may provide diagnostic value in this population. Further work is required to establish diagnostic thresholds and fully determine the place of IOS in screening athletes for airway dysfunction. [ABSTRACT FROM AUTHOR]

Published
2016
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