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101. Index

Author

Bertucci, Paola

Published
2023

103. Notes

Author

Bertucci, Paola

Published
2023

105. Conclusion

Author

Bertucci, Paola

Published
2023

112. The rate of epigenetic drift scales with maximum lifespan across mammals

Author

Emily M. Bertucci-Richter and Benjamin B. Parrott

Subjects
Science
Abstract

Abstract Epigenetic drift or “disorder” increases across the mouse lifespan and is suggested to underlie epigenetic clock signals. While the role of epigenetic drift in determining maximum lifespan across species has been debated, robust tests of this hypothesis are lacking. Here, we test if epigenetic disorder at various levels of genomic resolution explains maximum lifespan across four mammal species. We show that epigenetic disorder increases with age in all species and at all levels of genomic resolution tested. The rate of disorder accumulation occurs faster in shorter lived species and corresponds to species adjusted maximum lifespan. While the density of cytosine-phosphate-guanine dinucleotides (“CpGs”) is negatively associated with the rate of age-associated disorder accumulation, it does not fully explain differences across species. Our findings support the hypothesis that the rate of epigenetic drift explains maximum lifespan and provide partial support for the hypothesis that CpG density buffers against epigenetic drift.

Published
2023
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113. Statistical distribution of mirror-mode-like structures in the magnetosheaths of unmagnetized planets – Part 2: Venus as observed by the Venus Express spacecraft

Author

M. Volwerk, C. Simon Wedlund, D. Mautner, S. Rojas Mata, G. Stenberg Wieser, Y. Futaana, C. Mazelle, D. Rojas-Castillo, C. Bertucci, and M. Delva

Subjects
Science, Physics, QC1-999, Geophysics. Cosmic physics, QC801-809
Abstract

In this series of papers, we present statistical maps of mirror-mode-like (MM) structures in the magnetosheaths of Mars and Venus and calculate the probability of detecting them in spacecraft data. We aim to study and compare them with the same tools and a similar payload at both planets. We consider their dependence on extreme ultraviolet (EUV) solar flux levels (high and low). The detection of these structures is done through magnetic-field-only criteria, and ambiguous determinations are checked further. In line with many previous studies at Earth, this technique has the advantage of using one instrument (a magnetometer) with good time resolution, facilitating comparisons between planetary and cometary environments. Applied to the magnetometer data of the Venus Express (VEX) spacecraft from May 2006 to November 2014, we detect structures closely resembling MMs lasting in total more than 93 000 s, corresponding to about 0.6 % of VEX's total time spent in Venus's plasma environment. We calculate MM-like occurrences normalized to the spacecraft's residence time during the course of the mission. Detection probabilities are about 10 % at most for any given controlling parameter. In general, MM-like structures appear in two main regions: one behind the shock and the other close to the induced magnetospheric boundary, as expected from theory. For solar maximum, the active region behind the bow shock is further inside the magnetosheath, near the solar minimum bow shock location. The ratios of the observations during solar minimum and maximum are slightly dependent on the depth ΔB/B of the structures; deeper structures are more prevalent at solar maximum. A dependence on solar EUV (F10.7) flux is also present, where at higher F10.7 flux the events occur at higher values than the daily-average value of the flux. The main dependence of the MM-like structures is on the condition of the bow shock: for quasi-perpendicular conditions, the MM occurrence rate is higher than for quasi-parallel conditions. However, when the shock becomes “too perpendicular” the chance of observing MM-like structures reduces again. Combining the plasma data from the Ion Mass Analyser (IMA on board Venus Express) with the magnetometer data shows that the instability criterion for MMs is reduced in the two main regions where the structures are measured, whereas it is still enhanced in the region between these two regions, implying that the generation of MMs is transferring energy from the particles to the field. With the addition of the Electron Spectrometer (ELS on board Venus Express) data, it is possible to show that there is an anti-phase between the magnetic field strength and the density for the MM-like structures. This study is Part 2 of a series of papers on the magnetosheaths of Mars and Venus.

Published
2023
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114. Immunologic constant of rejection as a predictive biomarker of immune checkpoint inhibitors efficacy in non-small cell lung cancer

Author

Alice Mogenet, Pascal Finetti, Emilie Denicolai, Laurent Greillier, Pascaline Boudou-Rouquette, François Goldwasser, Gwenael Lumet, Michele Ceccarelli, Daniel Birnbaum, Davide Bedognetti, Emilie Mamessier, Fabrice Barlesi, François Bertucci, and Pascale Tomasini

Subjects
Lung cancer, ICR signature, Immune therapy, Biomarkers, Immune checkpoints inhibitors, Transcriptomics, Medicine
Abstract

Abstract Background Anti-PD1/PDL1 immune checkpoint inhibitors (ICI) transformed the prognosis of patients with advanced non-small cell lung cancer (NSCLC). However, the response rate remains disappointing and toxicity may be life-threatening, making urgent identification of biomarkers predictive for efficacy. Immunologic Constant of Rejection signature (ICR) is a 20-gene expression signature of cytotoxic immune response with prognostic value in some solid cancers. Our objective was to assess its predictive value for benefit from anti-PD1/PDL1 in patients with advanced NSCLC. Methods We retrospectively profiled 44 primary tumors derived from NSCLC patients treated with ICI as single-agent in at least the second-line metastatic setting. Transcriptomic analysis was performed using the nCounter® analysis system and the PanCancer Immune Profiling Panel. We then pooled our data with clinico-biological data from four public gene expression data sets, leading to a total of 162 NSCLC patients treated with single-agent anti-PD1/PDL1. ICR was applied to all samples and correlation was searched between ICR classes and the Durable Clinical Benefit (DCB), defined as stable disease or objective response according to RECIST 1.1 for a minimum of 6 months after the start of ICI. Results The DCB rate was 29%; 22% of samples were classified as ICR1, 30% ICR2, 22% ICR3, and 26% ICR4. These classes were not associated with the clinico-pathological variables, but showed enrichment from ICR1 to ICR4 in quantitative/qualitative markers of immune response. ICR2-4 class was associated with a 5.65-fold DCB rate when compared with ICR1 class. In multivariate analysis, ICR classification remained associated with DCB, independently from PDL1 expression and other predictive immune signatures. By contrast, it was not associated with disease-free survival in 556 NSCLC TCGA patients untreated with ICI. Conclusion The 20-gene ICR signature was independently associated with benefit from anti-PD1/PDL1 ICI in patients with advanced NSCLC. Validation in larger retrospective and prospective series is warranted.

Published
2023
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117. Improved nationwide survival of sarcoma patients with a network of reference centers

Author

Blay, J.Y., Penel, N., Valentin, T., Anract, P., Duffaud, F., Dufresne, A., Verret, B., Cordoba, A., Italiano, A., Brahmi, M., Henon, C., Amouyel, T., Ray-Coquard, I., Ferron, G., Boudou-Rouquette, P., Tlemsani, C., Salas, S., Rochwerger, R., Faron, M., Bompas, E., Ducassou, A., Gangloff, D., Gouin, F., Firmin, N., Piperno-Neumann, S., Rios, M., Ropars, M., Kurtz, J.E., Le Nail, L.R., Bertucci, F., Carrere, S., Llacer, C., Watson, S., Bonvalot, S., Leroux, A., Perrin, C., Gantzer, J., Pracht, M., Narciso, B., Monneur, A., Lebbe, C., Hervieu, A., Saada-Bouzid, E., Dubray-Longeras, P., Fiorenza, F., Chaigneau, L., Nevieres, Z.-M., Soibinet, P., Bouché, O., Guillemet, C., Spano, J.P., Ruzic, J.C., Isambert, N., Vaz, G., Meeus, P., Karanian, M., Ngo, C., Coindre, J.M., De Pinieux, G., Le Loarer, F., Ducimetiere, F., Chemin, C., Morelle, M., Toulmonde, M., and Le Cesne, A.

Published
2024
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118. A Spectral Dominance Approach to Large Random Matrices

Author

Bertucci, Charles, Debbah, Mérouane, Lasry, Jean-Michel, and Lions, Pierre-Louis

Subjects
Mathematics - Analysis of PDEs, Mathematics - Probability
Abstract

This paper presents a novel approach to characterize the dynamics of the limit spectrum of large random matrices. This approach is based upon the notion we call "spectral dominance". In particular, we show that the limit spectral measure can be determined as the derivative of the unique viscosity solution of a partial integro-differential equation. This also allows to make general and "short" proofs for the convergence problem. We treat the cases of Dyson Brownian motions, Wishart processes and present a general class of models for which this characterization holds.

Published
2021

119. Pope Lick Monster said to lure victims in front of trains

Author

Bertucci, Leo

Subjects
Louisville, Kentucky -- Myths and legends, Monsters -- Myths and legends, News, opinion and commentary
Abstract

Byline: Leo Bertucci, Louisville Courier Journal, USA TODAY NETWORK In southeast Louisville, Kentucky, tales of the horrifying Pope Lick Monster, a human-animal hybrid that lives under the Norfolk Southern Railroad [...]

Published
2024

120. Detection of the Crab Nebula with the 9.7 m Prototype Schwarzschild-Couder Telescope

Author

Adams, C. B., Alfaro, R., Ambrosi, G., Ambrosio, M., Aramo, C., Arlen, T., Batista, P. I., Benbow, W., Bertucci, B., Bissaldi, E., Biteau, J., Bitossi, M., Boiano, A., Bonavolontà, C., Bose, R., Bouvier, A., Brill, A., Brown, A. M., Buckley, J. H., Byrum, K., Cameron, R. A., Canestrari, R., Capasso, M., Caprai, M., Covault, C. E., Depaoli, D., Errando, M., Fegan, S., Feng, Q., Fiandrini, E., Foote, G., Fortin, P., Funk, S., Furniss, A., Garfias, F., Gent, A., Giglietto, N., Giordano, F., Giro, E., González, M. M., Guarino, V., Halliday, R., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Ionica, M., Iriarte, A., Jin, W., Johnson, C. A., Kaaret, P., Kieda, D., Kim, B., Kuznetsov, A., Lapington, J. S., Licciulli, F., Loporchio, S., Mason, V., Meagher, K., Meures, T., Mode, B. A. W., Mognet, S. A. I., Mukherjee, R., Nguyen, T., Nieto, D., Okumura, A., Otte, N., La Palombara, N., Pantaleo, F. R., Paoletti, R., Pareschi, G., Petrashyk, A., Di Pierro, F., Pueschel, E., Reynolds, P. T., Ribeiro, D., Richards, G., Roache, E., Ross, D., Rousselle, J., Rugliancich, A., Ruíz-Díaz-Soto, J., Santander, M., Schlenstedt, S., Schneider, M., Scuderi, S., Shang, R., Sironi, G., Stevenson, B., Stiaccini, L., Tajima, H., Taylor, L. P., Thornhill, J., Tosti, L., Tovmassian, G., Vagelli, V., Valentino, M., Vandenbroucke, J., Vassiliev, V. V., Di Venere, L., Wakely, S. P., Watson, J. J., White, R., Wilcox, P., Williams, D. A., Wood, M., Yu, P., and Zink, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Schwarzschild-Couder Telescope (SCT) is a telescope concept proposed for the Cherenkov Telescope Array. It employs a dual-mirror optical design to remove comatic aberrations over an $8^{\circ}$ field of view, and a high-density silicon photomultiplier camera (with a pixel resolution of 4 arcmin) to record Cherenkov emission from cosmic ray and gamma-ray initiated particle cascades in the atmosphere. The prototype SCT (pSCT), comprising a 9.7 m diameter primary mirror and a partially instrumented camera with 1536 pixels, has been constructed at the Fred Lawrence Whipple Observatory. The telescope was inaugurated in January 2019, with commissioning continuing throughout 2019. We describe the first campaign of observations with the pSCT, conducted in January and February of 2020, and demonstrate the detection of gamma-ray emission from the Crab Nebula with a statistical significance of $8.6\sigma$., Comment: 13 pages, 12 figures, 3 tables, submitted to Astroparticle Physics

Published
2020
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123. A randomized study of 6 versus 3 years of adjuvant imatinib in patients with localized GIST at high risk of relapse

Author

Blay, J.-Y., Schiffler, C., Bouché, O., Brahmi, M., Duffaud, F., Toulmonde, M., Landi, B., Lahlou, W., Pannier, D., Bompas, E., Bertucci, F., Chaigneau, L., Collard, O., Pracht, M., Henon, C., Ray-Coquard, I., Armoun, K., Salas, S., Spalato-Ceruso, M., Adenis, A., Verret, B., Penel, N., Moreau-Bachelard, C., Italiano, A., Dufresne, A., Metzger, S., Chabaud, S., Perol, D., and Le Cesne, A.

Published
2024
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124. Sclerosing Epithelioid Fibrosarcoma (SEF) versus Low Grade Fibromyxoid Sarcoma (LGFMS): Presentation and outcome in the nationwide NETSARC+ series of 330 patients over 13 years

Author

Blay, JY, Tlemsani, C., Toulmonde, M., Italiano, A., Rios, M., Bompas, E., Valentin, T., Duffaud, F., Le Nail, LR, Watson, S., Firmin, N., Dubray-Longeras, P., Ropars, M., Perrin, C., Hervieu, A., Lebbe, C., Saada-Bouzid, E., Soibinet, P., Fiorenza, F., Bertucci, F., Boudou, P., Vaz, G., Bonvalot, S., Honoré, C., Marec-Berard, P., Minard, V., Cleirec, M., Biau, D., Meeus, P., Babinet, A., Dumaine, V., Carriere, S., Fau, M., Decanter, G., Gouin, F., Ngo, C., Le Loarer, F., Karanian, M., Meurgey, A., Dufresne, A., Brahmi, M., Chemin-Airiau, C., Ducimetiere, F., Penel, N., and Le Cesne, A.

Published
2024
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129. Clinical, pathological, and comprehensive molecular analysis of the uterine clear cell carcinoma: a retrospective national study from TMRG and GINECO network

Author

Elsa Nigon, Claudia Lefeuvre-Plesse, Alejandra Martinez, Céline Chauleur, Alain Lortholary, Laure Favier, Anne-Sophie Bats, Arnaud Guille, José AdélaÏde, Pascal Finetti, Victoire de Casteljac, Magali Provansal, Emilie Mamessier, François Bertucci, Isabelle Ray-Coquard, and Renaud Sabatier

Subjects
Uterine cancer, Clear cell carcinoma, Tissue micro-array, Genomics, Gene expression profiling, Medicine
Abstract

Abstract Background Uterine clear cell carcinomas (CCC) represent less than 5% of uterine cancers. Their biological characteristics and clinical management remain uncertain. A multicenter study to explore both clinical and molecular features of these rare tumors was conducted. Methods This multicenter retrospective national study was performed within the French TMRG (Rare Gynecologic Malignant Tumors) network. Clinical data and, when available, FFPE blocks were collected. Clinical features, treatments, and outcome (progression-free survival (PFS) and overall survival (OS)) were analyzed and correlated to the protein (tissue micro-array), RNA (Nanostring nCounter® technology), and DNA (array-Comparative Genomic hybridization and target-next generation sequencing) levels using the tumor samples available. Results Sixty-eight patients with uterine CCC were enrolled, 61 from endometrial localization and 5 with cervix localization. Median age at diagnosis was 68.9 years old (range 19–89.7). Most tumors were diagnosed at an early stage (78% FIGO stage I–II). Hysterectomy (performed in 90%) and lymph node dissection (80%) were the most frequent surgical treatment. More than 70% of patients received external beam radiotherapy and 57% received brachytherapy. Nearly half (46%) of the patients received chemotherapy. After a median follow-up of 24.7 months, median PFS was 64.8 months (95 CI [5.3–124.4]) and median OS was 79.7 (IC95 [31.0–128.4]). Low hormone receptor expression (13% estrogen-receptor positive), frequent PI3K pathway alterations (58% PTEN loss, 50% PIK3CA mutations), and P53 abnormalities (41%) were observed. Mismatch repair deficiency was identified in 20%. P16 expression was associated with shorter PFS (HR = 5.88, 95 CI [1.56–25], p = 0.009). Transcriptomic analyzes revealed a specific transcriptomic profile notably with a high expression of immune response-associated genes in uterine CCC displaying a very good overall prognosis. Conclusions Uterine CCC reported to be potentially MSI high, hormone receptors negative, and sometimes TP53 mutated. However, some patients with immune response-associated features and better prognosis may be candidate to treatment de-escalation and immunotherapy.

Published
2023
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130. Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study

Author

Pierfrancesco Tassone, Maria Teresa Di Martino, Mariamena Arbitrio, Lucia Fiorillo, Nicoletta Staropoli, Domenico Ciliberto, Alessia Cordua, Francesca Scionti, Bernardo Bertucci, Angela Salvino, Mariangela Lopreiato, Fredrik Thunarf, Onofrio Cuomo, Maria Cristina Zito, Maria Rosanna De Fina, Amelia Brescia, Simona Gualtieri, Caterina Riillo, Francesco Manti, Daniele Caracciolo, Vito Barbieri, Eugenio Donato Di Paola, Adele Emanuela Di Francesco, and Pierosandro Tagliaferri

Subjects
miRNA therapeutics, microRNA, miRNA, RNA therapeutics, Non-coding RNA therapeutics, miR-221, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background We developed a 13-mer locked nucleic acid (LNA) inhibitor of miR-221 (LNA-i-miR-221) with a full phosphorothioate (PS)-modified backbone. This agent downregulated miR-221, demonstrated anti-tumor activity against human xenografts in mice, and favorable toxicokinetics in rats and monkeys. Allometric interspecies scaling allowed us to define the first-in-class LNA-i-miR-221 safe starting dose for the clinical translation. Methods In this first-in-human, open-label, dose-escalation phase 1 trial, we enrolled progressive cancer patients (aged ≥ 18 years) with ECOG 0–2 into 5 cohorts. The treatment cycle was based on a 30-min IV infusion of LNA-i-miR-221 on 4 consecutive days. Three patients within the first cohort were treated with 2 cycles (8 infusions), while 14 patients were treated with a single course (4 infusions); all patients were evaluated for phase 1 primary endpoint. The study was approved by the Ethics Committee and Regulatory Authorities (EudraCT 2017-002615-33). Results Seventeen patients received the investigational treatment, and 16 were evaluable for response. LNA-i-miR-221 was well tolerated, with no grade 3–4 toxicity, and the MTD was not reached. We recorded stable disease (SD) in 8 (50.0%) patients and partial response (PR) in 1 (6.3%) colorectal cancer case (total SD + PR: 56.3%). Pharmacokinetics indicated non-linear drug concentration increase across the dose range. Pharmacodynamics demonstrated concentration-dependent downregulation of miR-221 and upregulation of its CDKN1B/p27 and PTEN canonical targets. Five mg/kg was defined as the recommended phase II dose. Conclusions The excellent safety profile, the promising bio-modulator, and the anti-tumor activity offer the rationale for further clinical investigation of LNA-i-miR-221 (ClinTrials.Gov: NCT04811898).

Published
2023
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131. Assessment and Treatment Strategies for the Aesthetic Improvement of the Lower Face and Neck

Author

Chiu A, Bertucci V, Coimbra DD, and Li D

Subjects
chin, jaw, patient satisfaction, plastic surgery, treatment outcomes, algorithms, decision trees, Dermatology, RL1-803
Abstract

Annie Chiu,1 Vince Bertucci,2 Daniel Dal’Asta Coimbra,3 Dan Li4 1The Derm Institute, Redondo Beach, CA, USA; 2Private Practice, Woodbridge, Vaughan, ON, Canada; 3Department of Cosmetic Dermatology at Santa Casa de Misericórdia, Rio de Janeiro, RJ, Brazil; 4Department of Plastic and Reconstructive Surgery, Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Annie Chiu, The Derm Institute, 1636 Aviation Boulevard, #201, Redondo Beach, CA, 90278, USA, Tel +1 (310) 939-9800, Fax +1 (310) 939-9888, Email drchiu@thederminstitute.comBackground: Interest in aesthetic rejuvenation of the lower face and neck is growing, but published expert guidance is limited.Objective: Review aesthetic concerns of the lower face and neck and provide expert guidance on evaluation and treatment.Methods: Twelve international experts participated in an advisory board on lower face and neck aesthetic treatment. They completed a premeeting survey and met twice, reviewing responses and discussing patient evaluation and treatment strategies. They developed decision tree algorithms on patient assessment and treatment planning and sequencing, using clinical cases as a reference.Results: Treatment concerns include neck and lower face skin laxity, structural bone deficiency, insufficient or excess volume, submental fat, jowls, platysma bands, and masseter muscle prominence. Advisors agreed that the lower face and neck may be the most challenging areas to assess and treat; treatment goals include lower facial contour and overall facial harmony/balance. Advisors recommended first ruling out a surgical approach, then determining whether midface treatment is needed to support the lower face, and lastly evaluating the lower face for significant submental fat, excess or insufficient volume, and structural bone deficiency. To treat the lower face and neck, an anatomical layer approach, moving from deep to superficial layers, beginning with structural support, was recommended. Assessment and treatment decision trees were based on this approach.Conclusion: The lower face and neck are important but underrecognized areas of aesthetic concern. This article provides expert guidance and a suggested algorithm for assessment and treatment aimed at achieving satisfying and harmonious facial aesthetic results.Keywords: Chin, jaw, patient satisfaction, plastic surgery, treatment outcomes, algorithms, decision trees

Published
2023

132. Comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non-inflammatory breast cancer reveals AURKA as a potential treatment target

Author

François Richard, Maxim De Schepper, Marion Maetens, Sophia Leduc, Edoardo Isnaldi, Tatjana Geukens, Karen Van Baelen, Ha-Linh Nguyen, Peter Vermeulen, Steven Van Laere, François Bertucci, Naoto Ueno, Luc Dirix, Giuseppe Floris, Elia Biganzoli, and Christine Desmedt

Subjects
Inflammatory breast cancer, Metastatic breast cancer, Genomic alterations, AURKA-Inhibitors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Inflammatory breast cancer (IBC) is a rare but aggressive subtype of breast cancer, mainly characterized using primary tumor samples. Here, using public datasets, we compared the genomic alterations in primary and metastatic samples from patients with metastatic IBC versus patients with metastatic non-IBC. We observed a higher frequency of AURKA amplification in IBC. We further showed that AURKA amplification was associated with increased AURKA mRNA expression, which we demonstrated was higher in IBC. Finally, higher protein expression of AURKA was associated with worse prognosis in patients with IBC. These findings deserve further investigation given the existence of AURKA-inhibitors.

Published
2023
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133. Verification of the Optical System of the 9.7-m Prototype Schwarzschild-Couder Telescope

Author

Adams, C., Alfaro, R., Ambrosi, G., Ambrosio, M., Aramo, C., Benbow, W., Bertucci, B., Bissaldi, E., Bitossi, M., Boiano, A., Bonavolontà, C., Bose, R., Brill, A., Buckley, J. H., Byrum, K., Cameron, R. A., Capasso, M., Caprai, M., Covault, C. E., Di Venere, L., Fegan, S., Feng, Q., Fiandrini, E., Furniss, A., Garczarczyk, M., Garfias, F., Gent, A., Giglietto, N., Giordano, F., González, M. M., Halliday, R., Hervet, O., Hughes, G., Humensky, T. B., Ionica, M., Iriarte, A., Jin, W., Kaarat, P., Kieda, D., Kim, B., Licciulli, F., Limon, M., Loporchio, S., Masone, V., Meures, T., Mode, B. A. W., Mukherjee, R., Nieto, D., Okumura, A., Otte, N., La Palombara, N., Pantaleo, F. R., Paoletti, R., Pareschi, G., Petrashyk, A., Powell, J., Powell, K., Ribeiro, D., Roache, E., Rousselle, J., Rugliancich, A., Ruíz-Díaz-Soto, J., Santander, M., Schlenstedt, S., Scuderi, S., Shang, R., Sironi, G., Stevenson, B., Stiaccini, L., Taylor, L. P., Tosti, L., Tovmassian, G., Vagelli, V., Valentino, M., Vandenbroucke, J., Vassiliev, V. V., Wakely, S. P., Wilcox, P., Williams, D. A., and Yu, P.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

For the first time in the history of ground-based $\gamma$-ray astronomy, the on-axis performance of the dual mirror, aspheric, aplanatic Schwarzschild-Couder optical system has been demonstrated in a $9.7$-m aperture imaging atmospheric Cherenkov telescope. The novel design of the prototype Schwarzschild-Couder Telescope (pSCT) is motivated by the need of the next-generation Cherenkov Telescope Array (CTA) observatory to have the ability to perform wide ($\geq 8^{\circ}$) field-of-view observations simultaneously with superior imaging of atmospheric cascades (resolution of $0.067^{\circ}$ per pixel or better). The pSCT design, if implemented in the CTA installation, has the potential to improve significantly both the $\gamma$-ray angular resolution and the off-axis sensitivity of the observatory, reaching nearly the theoretical limit of the technique and thereby making a major impact on the CTA observatory sky survey programs, follow-up observations of multi-messenger transients with poorly known initial localization, as well as on the spatially resolved spectroscopic studies of extended $\gamma$-ray sources. This contribution reports on the initial alignment procedures and point-spread-function results for the challenging segmented aspheric primary and secondary mirrors of the pSCT., Comment: 19 pages, 11 figures, proceedings for SPIE Optical Engineering + Applications, 2020, Online Only

Published
2020
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134. Numerical modeling of cosmic rays in the heliosphere: Analysis of proton data from AMS-02 and PAMELA

Author

Fiandrini, Emanuele, Tomassetti, Nicola, Bertucci, Bruna, Donnini, Federico, Graziani, Maura, Khiali, Behrouz, and Conde, Alejandro Reina

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics, High Energy Physics - Phenomenology, Physics - Space Physics
Abstract

Galactic cosmic rays (CRs) inside the heliosphere are affected by solar modulation. To investigate this phenomenon and its underlying physical mechanisms, we have performed a data-driven analysis of the temporal dependence of the CR proton flux over the solar cycle. The modulation effect was modeled by means of stochastic simulations of cosmic particles in the heliosphere. The model were constrained using measurements of CR protons made by AMS-02 and PAMELA experiments on monthly basis from 2006 to 2017. With a global statistical analysis of these data, we have determined the key model parameters governing CR diffusion, its dependence on the particle rigidity, and its evolution over the solar cycle. Our results span over epochs of solar minimum, solar maximum, as well as epochs with magnetic reversal and opposite polarities. Along with the evolution of the CR transport parameters, we study their relationship with solar activity proxies and interplanetary parameters. We find that the rigidity dependence of the parallel mean free path of CR diffusion shows a remarkable time dependence, indicating a long-term variability in the interplanetary turbulence that interchanges across different regimes over the solar cycle. The evolution of the diffusion parameters show a delayed correlation with solar activity proxies, reflecting the dynamics of the heliospheric plasma, and distinct dependencies for opposite states of magnetic polarity, reflecting the influence of charge-sign dependent drift in the CR modulation., Comment: 20 pages, 14 figures, to appear in Physical Review D

Published
2020
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135. Sensitivity of the Cherenkov Telescope Array for probing cosmology and fundamental physics with gamma-ray propagation

Author

Consortium, The Cherenkov Telescope Array, Abdalla, H., Abe, H., Acero, F., Acharyya, A., Adam, R., Agudo, I., Aguirre-Santaella, A., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., B, R. Alves, Amati, L., Amato, E., Ambrosi, G., Angüner, E. O., Araudo, A., Armstrong, T., Arqueros, F., Arrabito, L., Asano, K., Ascasíbar, Y., Ashley, M., Backes, M., Balazs, C., Balbo, M., Balmaverde, B., Larriva, A. Baquero, Martins, V. Barbosa, Barkov, M., Baroncelli, L., de Almeida, U. Barres, Barrio, J. A., Batista, P., Becerra, J., Becherini, Y., Beck, G., Tjus, J. Becker, Belmont, R., Benbow, W., Bernardini, E., Berti, A., Berton, M., Bertucci, B., Beshley, V., Bi, B., Biasuzzi, B., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Bocchino, F., Boisson, C., Bolmont, J., Bonanno, G., Arbeletche, L. Bonneau, Bonnoli, G., Bordas, P., Bottacini, E., Böttcher, M., Bozhilov, V., Bregeon, J., Brill, A., Brown, A. M., Bruno, P., Bruno, A., Bulgarelli, A., Burton, M., Buscemi, M., Caccianiga, A., Cameron, R., Capasso, M., Caprai, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Carosi, R., Carosi, A., Casanova, S., Cascone, E., Cauz, D., Cerny, K., Cerruti, M., Chadwick, P., Chaty, S., Chen, A., Chernyakova, M., Chiaro, G., Chiavassa, A., Chytka, L., Conforti, V., Conte, F., Contreras, J. L., Coronado-Blazquez, J., Cortina, J., Costa, A., Costantini, H., Covino, S., Cristofari, P., Cuevas, O., D'Ammando, F., Daniel, M. K., Davies, J., Dazzi, F., De Angelis, A., de Lavergne, M. de Bony, De Caprio, V., Anjos, R. de Cássia dos, Pino, E. M. de Gouveia Dal, De Lotto, B., De Martino, D., de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., de Souza, V., Delgado, C., Della Ceca, R., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Pierro, F., Díaz, C., Díaz-Bahamondes, C., Diebold, S., Djannati-Ataï, A., Dmytriiev, A., Domínguez, A., Donini, A., Dorner, D., Doro, M., Dournaux, J., Dwarkadas, V. V., Ebr, J., Eckner, C., Einecke, S., Ekoume, T. R. N., Elsässer, D., Emery, G., Evoli, C., Fairbairn, M., Falceta-Goncalves, D., Fegan, S., Feng, Q., Ferrand, G., Fiandrini, E., Fiasson, A., Fioretti, V., Foffano, L., Fonseca, M. V., Font, L., Fontaine, G., Franco, F. J., Coromina, L. Freixas, Fukami, S., Fukazawa, Y., Fukui, Y., Gaggero, D., Galanti, G., Gammaldi, V., Garcia, E., Garczarczyk, M., Gascon, D., Gaug, M., Gent, A., Ghalumyan, A., Ghirlanda, G., Gianotti, F., Giarrusso, M., Giavitto, G., Giglietto, N., Giordano, F., Glicenstein, J., Goldoni, P., González, J. M., Gourgouliatos, K., Grabarczyk, T., Grandi, P., Granot, J., Grasso, D., Green, J., Grube, J., Gueta, O., Gunji, S., Halim, A., Harvey, M., Collado, T. Hassan, Hayashi, K., Heller, M., Cadena, S. Hernández, Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Hughes, G., Hütten, M., Iarlori, M., Inada, T., Inoue, S., Insolia, A., Ionica, M., Iori, M., Jacquemont, M., Jamrozy, M., Janecek, P., Martínez, I. Jiménez, Jin, W., Jung-Richardt, I., Jurysek, J., Kaaret, P., Karas, V., Karkar, S., Kawanaka, N., Kerszberg, D., Khélifi, B., Kissmann, R., Knödlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kong, A., Kosack, K., Kubo, H., La Palombara, N., Lamanna, G., Lang, R. G., Lapington, J., Laporte, P., Lemoine-Goumard, M., Lenain, J., Leone, F., Leto, G., Leuschner, F., Lindfors, E., Lloyd, S., Lohse, T., Lombardi, S., Longo, F., Lopez, A., López, M., López-Coto, R., Loporchio, S., Lucarelli, F., Luque-Escamilla, P. L., Lyard, E., Maggio, C., Majczyna, A., Makariev, M., Mallamaci, M., Mandat, D., Maneva, G., Manganaro, M., Manicò, G., Marcowith, A., Marculewicz, M., Markoff, S., Marquez, P., Martí, J., Martinez, O., Martínez, M., Martínez, G., Martínez-Huerta, H., Maurin, G., Mazin, D., Mbarubucyeye, J. D., Miranda, D. Medina, Meyer, M., Micanovic, S., Miener, T., Minev, M., Miranda, J. M., Mitchell, A., Mizuno, T., Mode, B., Moderski, R., Mohrmann, L., Molina, E., Montaruli, T., Moralejo, A., Merino, J. Morales, Morcuende-Parrilla, D., Morselli, A., Mukherjee, R., Mundell, C., Murach, T., Muraishi, H., Nagai, A., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nievas, M., Nikołajuk, M., Nishijima, K., Noda, K., Nosek, D., Nozaki, S., O'Brien, P., Ohira, Y., Ohishi, M., Oka, T., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Osborne, J. P., Ostrowski, M., Oya, I., Pagliaro, A., Palatka, M., Paneque, D., Pantaleo, F. R., Paredes, J. M., Parmiggiani, N., Patricelli, B., Pavletić, L., Pe'er, A., Pech, M., Pecimotika, M., Peresano, M., Persic, M., Petruk, O., Pfrang, K., Piatteli, P., Pietropaolo, E., Pillera, R., Pilszyk, B., Pimentel, D., Pintore, F., Pita, S., Pohl, M., Poireau, V., Polo, M., Prado, R. R., Prast, J., Principe, G., Produit, N., Prokoph, H., Prouza, M., Przybilski, H., Pueschel, E., Pühlhofer, G., Pumo, M. L., Punch, M., Queiroz, F., Quirrenbach, A., Rando, R., Razzaque, S., Rebert, E., Recchia, S., Reichherzer, P., Reimer, O., Reimer, A., Renier, Y., Reposeur, T., Rhode, W., Ribeiro, D., Ribó, M., Richtler, T., Rico, J., Rieger, F., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Ramirez, J. C. Rodriguez, Vázquez, J. J. Rodríguez, Romano, P., Romeo, G., Roncadelli, M., Rosado, J., de Leon, A. Rosales, Rowell, G., Rudak, B., Rujopakarn, W., Russo, F., Sadeh, I., Saha, L., Saito, T., Greus, F. Salesa, Sanchez, D., Sánchez-Conde, M., Sangiorgi, P., Sano, H., Santander, M., Santos, E. M., Sanuy, A., Sarkar, S., Saturni, F. G., Sawangwit, U., Scherer, A., Schleicher, B., Schovanek, P., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Arroyo, M. Seglar, Sergijenko, O., Servillat, M., Seweryn, K., Shalchi, A., Sharma, P., Shellard, R. C., Siejkowski, H., Sinha, A., Sliusar, V., Slowikowska, A., Sokolenko, A., Sol, H., Specovius, A., Spencer, S., Spiga, D., Stamerra, A., Stanič, S., Starling, R., Stolarczyk, T., Straumann, U., Strišković, J., Suda, Y., Świerk, P., Tagliaferri, G., Takahashi, H., Takahashi, M., Tavecchio, F., Taylor, L., Tejedor, L. A., Temnikov, P., Terrier, R., Terzic, T., Testa, V., Tian, W., Tibaldo, L., Tonev, D., Torres, D. F., Torresi, E., Tosti, L., Tothill, N., Tovmassian, G., Travnicek, P., Truzzi, S., Tuossenel, F., Umana, G., Vacula, M., Vagelli, V., Valentino, M., Vallage, B., Vallania, P., van Eldik, C., Varner, G. S., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Veh, J., Vercellone, S., Vergani, S., Verguilov, V., Vettolani, G. P., Viana, A., Vigorito, C. F., Vitale, V., Vorobiov, S., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., Watson, J., White, M., White, R., Wiemann, R., Wierzcholska, A., Will, M., Williams, D. A., Wischnewski, R., Wolter, A., Yamazaki, R., Yanagita, S., Yang, L., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zaric, D., Zavrtanik, M., Zavrtanik, D., Zech, A., Zechlin, H., Zhdanov, V. I., and Živec, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The Cherenkov Telescope Array (CTA), the new-generation ground-based observatory for $\gamma$-ray astronomy, provides unique capabilities to address significant open questions in astrophysics, cosmology, and fundamental physics. We study some of the salient areas of $\gamma$-ray cosmology that can be explored as part of the Key Science Projects of CTA, through simulated observations of active galactic nuclei (AGN) and of their relativistic jets. Observations of AGN with CTA will enable a measurement of $\gamma$-ray absorption on the extragalactic background light with a statistical uncertainty below 15% up to a redshift $z=2$ and to constrain or detect $\gamma$-ray halos up to intergalactic-magnetic-field strengths of at least 0.3pG. Extragalactic observations with CTA also show promising potential to probe physics beyond the Standard Model. The best limits on Lorentz invariance violation from $\gamma$-ray astronomy will be improved by a factor of at least two to three. CTA will also probe the parameter space in which axion-like particles could constitute a significant fraction, if not all, of dark matter. We conclude on the synergies between CTA and other upcoming facilities that will foster the growth of $\gamma$-ray cosmology., Comment: 71 pages (including affiliations and references), 13 figures, 6 tables. Accepted in JCAP; matches published version. Corresponding authors: Jonathan Biteau, Julien Lefaucheur, Humberto Martinez-Huerta, Manuel Meyer, Santiago Pita, Ievgen Vovk

Published
2020
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136. Tracker-In-Calorimeter (TIC): a calorimetric approach to tracking gamma rays in space experiments

Author

Adriani, O., Ambrosi, G., Azzarello, P., Basti, A., Berti, E., Bertucci, B., Bigongiari, G., Bonechi, L., Bongi, M., Bottai, S., Brianzi, M., Brogi, P., Castellini, G., Catanzani, E., Checchia, C., D'Alessandro, R., Detti, S., Duranti, M., Finetti, N., Formato, V., Ionica, M., Maestro, P., Maletta, F., Marrocchesi, P. S., Mori, N., Pacini, L., Papini, P., Ricciarini, S., Silvestre, G., Spillantini, P., Starodubtsev, O., Stolzi, F., Suh, J. E., Sulaj, A., Tiberio, A., and Vannuccini, E.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

A multi-messenger, space-based cosmic ray detector for gamma rays and charged particles poses several design challenges due to the different instrumental requirements for the two kind of particles. Gamma-ray detection requires layers of high Z materials for photon conversion and a tracking device with a long lever arm to achieve the necessary angular resolution to separate point sources; on the contrary, charge measurements for atomic nuclei requires a thin detector in order to avoid unwanted fragmentation, and a shallow instrument so to maximize the geometric factor. In this paper, a novel tracking approach for gamma rays which tries to reconcile these two conflicting requirements is presented. The proposal is based on the Tracker-In-Calorimeter (TIC) design that relies on a highly-segmented calorimeter to track the incident gamma ray by sampling the lateral development of the electromagnetic shower at different depths. The effectiveness of this approach has been studied with Monte Carlo simulations and has been validated with test beam data of a detector prototype., Comment: 17 pages, 8 figures, 2 tables

Published
2020
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137. Sensitivity of the Cherenkov Telescope Array to a dark matter signal from the Galactic centre

Author

Consortium, The Cherenkov Telescope Array, Acharyya, A., Adam, R., Adams, C., Agudo, I., Aguirre-Santaella, A., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Batista, R. Alves, Amati, L., Ambrosi, G., Angüner, E. O., Antonelli, L. A., Aramo, C., Araudo, A., Armstrong, T., Arqueros, F., Asano, K., Ascasíbar, Y., Ashley, M., Balazs, C., Ballester, O., Larriva, A. Baquero, Martins, V. Barbosa, Barkov, M., de Almeida, U. Barres, Barrio, J. A., Bastieri, D., Becerra, J., Beck, G., Tjus, J. Becker, Benbow, W., Benito, M., Berge, D., Bernardini, E., Bernlöhr, K., Berti, A., Bertucci, B., Beshley, V., Biasuzzi, B., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Bocchino, F., Boisson, C., Arbeletche, L. Bonneau, Bordas, P., Bosnjak, Z., Bottacini, E., Bozhilov, V., Bregeon, J., Brill, A., Bringmann, T., Brown, A. M., Brun, P., Brun, F., Bruno, P., Bulgarelli, A., Burton, M., Burtovoi, A., Buscemi, M., Cameron, R., Capasso, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Carosi, R., Carosi, A., Casanova, S., Cascone, E., Cassol, F., Catalani, F., Cauz, D., Cerruti, M., Chadwick, P., Chaty, S., Chen, A., Chernyakova, M., Chiaro, G., Chiavassa, A., Chikawa, M., Chudoba, J., Çolak, M., Conforti, V., Coniglione, R., Conte, F., Contreras, J. L., Coronado-Blazquez, J., Costa, A., Costantini, H., Cotter, G., Cristofari, P., D'Aì, A., D'Ammando, F., Damone, L. A., Daniel, M. K., Dazzi, F., De Angelis, A., De Caprio, V., Anjos, R. de Cássia dos, Pino, E. M. de Gouveia Dal, De Lotto, B., De Martino, D., Wilhelmi, E. de Oña, De Palma, F., de Souza, V., Delgado, C., Giler, A. G. Delgado, della Volpe, D., Depaoli, D., Di Girolamo, T., Di Pierro, F., Di Venere, L., Diebold, S., Dmytriiev, A., Domínguez, A., Donini, A., Doro, M., Ebr, J., Eckner, C., Edwards, T. D. P., Ekoume, T. R. N., Elsässer, D., Evoli, C., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Ferrara, G., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Foffano, L., Fontaine, G., Fornieri, O., Franco, F. J., Fukami, S., Fukui, Y., Gaggero, D., Galaz, G., Gammaldi, V., Garcia, E., Garczarczyk, M., Gascon, D., Gent, A., Ghalumyan, A., Gianotti, F., Giarrusso, M., Giavitto, G., Giglietto, N., Giordano, F., Giuliani, A., Glicenstein, J., Gnatyk, R., Goldoni, P., González, M. M., Gourgouliatos, K., Granot, J., Grasso, D., Green, J., Grillo, A., Gueta, O., Gunji, S., Halim, A., Hassan, T., Heller, M., Cadena, S. Hernández, Hiroshima, N., Hnatyk, B., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Hughes, G., Humensky, T. B., Hütten, M., Iarlori, M., Inada, T., Inoue, S., Iocco, F., Iori, M., Jamrozy, M., Janecek, P., Jin, W., Jouvin, L., Jurysek, J., Karukes, E., Katarzyński, K., Kazanas, D., Kerszberg, D., Kherlakian, M. C., Kissmann, R., Knödlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kubo, H., Kushida, J., Lamanna, G., Lapington, J., Laporte, P., de Oliveira, M. A. Leigui, Lenain, J., Leone, F., Leto, G., Lindfors, E., Lohse, T., Lombardi, S., Longo, F., Lopez, A., López, M., López-Coto, R., Loporchio, S., Luque-Escamilla, P. L., Mach, E., Maggio, C., Maier, G., Mallamaci, M., de Almeida, R. Malta Nunes, Mandat, D., Manganaro, M., Mangano, S., Manicò, G., Marculewicz, M., Mariotti, M., Markoff, S., Marquez, P., Martí, J., Martinez, O., Martínez, M., Martínez, G., Martínez-Huerta, H., Maurin, G., Mazin, D., Mbarubucyeye, J. D., Miranda, D. Medina, Meyer, M., Miceli, M., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Mizuno, T., Mode, B., Moderski, R., Mohrmann, L., Molina, E., Montaruli, T., Moralejo, A., Morcuende-Parrilla, D., Morselli, A., Mukherjee, R., Mundell, C., Nagai, A., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nikołajuk, M., Ninci, D., Noda, K., Nosek, D., Nozaki, S., Ohira, Y., Ohishi, M., Ohtani, Y., Oka, T., Okumura, A., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, S., Orlando, E., Ostrowski, M., Oya, I., Pagano, I., Pagliaro, A., Palatiello, M., Pantaleo, F. R., Paredes, J. M., Pareschi, G., Parmiggiani, N., Patricelli, B., Pavletić, L., Pe'er, A., Pecimotika, M., Pérez-Romero, J., Persic, M., Petruk, O., Pfrang, K., Piano, G., Piatteli, P., Pietropaolo, E., Pillera, R., Pilszyk, B., Pintore, F., Pohl, M., Poireau, V., Prado, R. R., Prandini, E., Prast, J., Principe, G., Prokoph, H., Prouza, M., Przybilski, H., Pühlhofer, G., Pumo, M. L., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Recchia, S., Reimer, O., Reisenegger, A., Renier, Y., Rhode, W., Ribeiro, D., Ribó, M., Richtler, T., Rico, J., Rieger, F., Rinchiuso, L., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Ramirez, J. C. Rodriguez, Rojas, G., Romano, P., Romeo, G., Rosado, J., Rowell, G., Rudak, B., Russo, F., Sadeh, I., Hatlen, E. Sæther, Safi-Harb, S., Greus, F. Salesa, Salina, G., Sanchez, D., Sánchez-Conde, M., Sangiorgi, P., Sano, H., Santander, M., Santos, E. M., Santos-Lima, R., Sanuy, A., Sarkar, S., Saturni, F. G., Sawangwit, U., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Seglar-Arroyo, M., Sergijenko, O., Servillat, M., Seweryn, K., Shalchi, A., Sharma, P., Shellard, R. C., Siejkowski, H., Silk, J., Siqueira, C., Sliusar, V., Słowikowska, A., Sokolenko, A., Sol, H., Spencer, S., Stamerra, A., Stanič, S., Starling, R., Stolarczyk, T., Straumann, U., Strišković, J., Suda, Y., Suomijarvi, T., Świerk, P., Tavecchio, F., Taylor, L., Tejedor, L. A., Teshima, M., Testa, V., Tibaldo, L., Peixoto, C. J. Todero, Tokanai, F., Tonev, D., Tosti, G., Tosti, L., Tothill, N., Truzzi, S., Travnicek, P., Vagelli, V., Vallage, B., Vallania, P., van Eldik, C., Vandenbroucke, J., Varner, G. S., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Vergani, S., Verna, G., Viana, A., Vigorito, C. F., Vink, J., Vitale, V., Vorobiov, S., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., Watson, J., Weniger, C., White, R., White, M., Wiemann, R., Wierzcholska, A., Will, M., Williams, D. A., Wischnewski, R., Yanagita, S., Yang, L., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zakaria, A. A., Zampieri, L., Zanin, R., Zaric, D., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zhdanov, V. I., and Živec, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

We provide an updated assessment of the power of the Cherenkov Telescope Array (CTA) to search for thermally produced dark matter at the TeV scale, via the associated gamma-ray signal from pair-annihilating dark matter particles in the region around the Galactic centre. We find that CTA will open a new window of discovery potential, significantly extending the range of robustly testable models given a standard cuspy profile of the dark matter density distribution. Importantly, even for a cored profile, the projected sensitivity of CTA will be sufficient to probe various well-motivated models of thermally produced dark matter at the TeV scale. This is due to CTA's unprecedented sensitivity, angular and energy resolutions, and the planned observational strategy. The survey of the inner Galaxy will cover a much larger region than corresponding previous observational campaigns with imaging atmospheric Cherenkov telescopes. CTA will map with unprecedented precision the large-scale diffuse emission in high-energy gamma rays, constituting a background for dark matter searches for which we adopt state-of-the-art models based on current data. Throughout our analysis, we use up-to-date event reconstruction Monte Carlo tools developed by the CTA consortium, and pay special attention to quantifying the level of instrumental systematic uncertainties, as well as background template systematic errors, required to probe thermally produced dark matter at these energies. "Full likelihood tables complementing our analysis are provided here [ https://doi.org/10.5281/zenodo.4057987 ]", Comment: 68 pages (including references) and 26 figures; text identical to the version published in JCAP

Published
2020
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138. Monotone solutions for mean field games master equations : finite state space and optimal stopping

Author

Bertucci, Charles

Subjects
Mathematics - Analysis of PDEs
Abstract

We present a new notion of solution for mean field games master equations. This notion allows us to work with solutions which are merely continuous. We prove first results of uniqueness and stability for such solutions. It turns out that this notion is helpful to characterize the value function of mean field games of optimal stopping or impulse control and this is the topic of the second half of this paper. The notion of solution we introduce is only useful in the monotone case. We focus in this paper in the finite state space case.

Published
2020

139. The magnetic structure of the subsolar MPB current layer from MAVEN observations: Implications for the Hall electric force

Author

Boscoboinik, G., Bertucci, C., Gomez, D., Morales, L., Mazelle, C., Halekas, J., Gruesbeck, J., Mitchell, D., Jakosky, B., and Penou, E.

Subjects
Physics - Space Physics, Astrophysics - Earth and Planetary Astrophysics
Abstract

We report on the local structure of the Martian subsolar Magnetic Pileup Boundary (MPB) from minimum variance analysis of the magnetic field measured by the Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft for six orbits. In particular, we detect a well defined current layer within the MPB and provide a local estimate of its current density which results in a sunward Hall electric force. This force accounts for the deflection of the solar wind ions and the acceleration of electrons which carry the interplanetary magnetic field through the MPB into the Magnetic Pileup Region. We find that the thickness of the MPB current layer is of the order of both the upstream (magnetosheath) solar wind proton inertial length and convective gyroradius. This study provides a high resolution view of one of the components of the current system around Mars reported in recent works., Comment: 14 pages, 2 figures

Published
2020
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140. A class of short-term models for the oil industry addressing speculative storage

Author

Achdou, Yves, Bertucci, Charles, Lasry, Jean-Michel, Lions, Pierre Louis, Rostand, Antoine, and Scheinkman, Jose

Subjects
Mathematics - Analysis of PDEs
Abstract

This is a work in progress. The aim is to propose a plausible mechanism for the short term dynamics of the oil market based on the interaction of economic agents. This is a theoretical research which by no means aim at describing all the aspects of the oil market. In particular, we use the tools and terminology of game theory, but we do not claim that this game actually exists in the real world. In parallel, we are currently studying and calibrating a long term model for the oil industry, which addresses the interactions of a monopolists with a competitive fringe of small producers. It is the object of another paper that will be available soon. The present premiminary version does not contain all the economic arguments and all the connections with our long term model. It mostly addresses the description of the model, the equations and numerical simulations focused on the oil industry short term dynamics. A more complete version will be available soon.

Published
2020

141. Master equation for the finite state space planning problem

Author

Bertucci, Charles, Lasry, Jean-Michel, and Lions, Pierre-Louis

Subjects
Mathematics - Analysis of PDEs
Abstract

We present results of existence, regularity and uniqueness of solutions of the master equation associated with the mean field planning problem in the finite state space case, in the presence of a common noise. The results hold under monotonicity assumptions, which are used crucially in the different proofs of the paper. We also make a link with the trajectories induced by the solution of the master equation and start a discussion on the case of boundary conditions.

Published
2020
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142. Strategic advantages in mean field games with a major player

Author

Bertucci, Charles, Lasry, Jean-Michel, and Lions, Pierre-Louis

Subjects
Mathematics - Analysis of PDEs
Abstract

This note is concerned with a modeling question arising from the mean field games theory. We show how to model mean field games involving a major player which has a strategic advantage, while only allowing closed loop markovian strategies for all the players. We illustrate this property through three examples.

Published
2020

143. Diel cycle of two recurrent fish sounds from mesophotic coral reefs

Author

Xavier Raick, Pierre Collet, Under The Pole Consortium, David Lecchini, Frédéric Bertucci, and Eric Parmentier

Subjects
French Polynesia, mesophotic coral ecosystems, passive acoustic monitoring, bioacoustics, biophony, fish sounds, Aquaculture. Fisheries. Angling, SH1-691
Abstract

Mesophotic coral ecosystems (MCEs) are the deepest part of tropical coral reefs, ranging from depths of 30 to over 170 m. Despite their significance, MCEs remain largely unexplored due to the challenges associated with accessing these depths. However, the application of passive acoustic monitoring methods (PAM) is a suitable approach for studying fish communities within these unique habitats. In French Polynesia, recent PAM studies have unveiled a higher occurrence of frequency-modulated fish sounds in MCEs than in shallower reef environments. This study aims to further enhance our understanding of fish sounds in MCEs by examining their diel patterns, focusing specifically on the two most abundant frequency-modulated fish sounds that were recorded at depths of 60 and 120 m at six Polynesian islands. Both sound types occurred predominantly during the beginning and the end of nocturnal periods. The presence and abundance of these sounds exhibited variation between the islands, highlighting potential regional disparities in vocal activity or the bathymetric distribution of the sound-producing species. By characterizing the diel cycles and bathymetric differences in relation to their geographical distribution, this study offers preliminary insights into identifying the potential sound-producing species.

Published
2023
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144. A highly sensitive electrochemical magneto-genosensing assay for the specific detection of a single nucleotide variation in the KRAS oncogene in human plasma

Author

Simone Fortunati, Chiara Giliberti, Marco Giannetto, Alessandro Bertucci, Sabrina Capodaglio, Elena Ricciardi, Patrizio Giacomini, Valentina Bianchi, Andrea Boni, Ilaria De Munari, Roberto Corradini, and Maria Careri

Subjects
Point-of-Care, Precision medicine, KRAS, Colorectal cancer, Electrochemical genoassay, Magnetic microbeads, Biotechnology, TP248.13-248.65
Abstract

Liquid biopsy is a non-invasive and efficient technique for the detection of tumor biomarkers in biological fluids, which currently represents a new frontier in theranostics and precision medicine. Among mutations of the KRAS oncogene, p.G12D single nucleotide variation in the KRAS gene plays a central role in the early diagnosis and therapeutic treatment of colorectal cancer. In this context, we developed a highly sensitive magneto-genosensing assay based on PNA capture probes immobilized on magnetic microbeads. To detect the mutation of the KRAS oncogene, two capture probe sequences recognizing wild-type and p.G12D tumor DNA were used in association with a DNA signaling probe allowing for electrochemical detection using an enzyme conjugate. The assay conditions were optimized using a 32 full-factorial design, obtaining an outstanding specificity, evidenced by a remarkably lower (>95%) signal of the singly-mismatched- compared to that of fully-complementary-DNA. Ultra-high sensitivity was achieved in 10-fold diluted human plasma reaching detection limits of 818 fM for the p.G12D and 1.8 pM for the wild-type targets. The genosensing assay was tested on genomic tumor DNA samples provided by IRCCS-Regina Elena National Cancer Institute and finally integrated into a smart portable multichannel potentiostat capable of performing up to four simultaneous acquisitions. The developed magneto-genosensing assay demonstrated portability, simplicity, and high sensitivity, showing good potential as theranostic tool for personalized medicine in oncology.

Published
2023
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149. Prevalence and predictive role of hypertriglyceridemia in statin-treated patients at very high risk: Insights from the START study

Author

Steering Committee, De Luca (Chairman), L., Gulizia (co-chairman), M.M., Temporelli, P.L., Riccio, C., Colivicchi, F., Amico, A.F., Formigli, D., Geraci, G., Di Lenarda, A., Executive Committee, De Luca, L., Maggioni, A.P., Lucci, D., Coordinating Center, Lorimer, A., Orsini, G., Gonzini, L., Fabbri, G., Priami, P., Maras, P., Ramani, F., Falcone, C., Passarelli, I., Mauri, S., Calabrò, P., Bianchi, R., Di Palma, G., Mascia, F., Vetrano, A., Fusco, A., Proia, E., Aiello, A., Tomai, F., Licitra, R., Petrolini, A., Bosco, B., Magliari, F., Callerame, M., Mazzella, T., Lettica, G.V., Coco, G., Incao, F., Marinacci, L., D'Addario, S., Tartaglione, S.N., Ubaldi, S., Sanchez, F.A., Costa, P., Manca, G., Failla, M., Scherillo, M., Procaccini, V., Senni, M., Luminita, E.M., Bonomo, P., Mossa, C., Corda, S., Colavita, A.R., Trevisonno, G., Vizzari, G., Cosentino, N., Formaro, C., Paolillo, C., Nalin, I.L., De Rosa, F.M., Fontana, F., Fuscaldo, G.F., Passamonti, E., Bertella, E., Calvaruso, E.V., Varani, E., Tani, F., Cicchitelli, G., Gabrielli, D., Paoloni, P., Marziali, A., Campo, G., Tebaldi, M., Biscaglia, S., Biase, M Di, Brunetti, N.D., Gallotta, A.M., Mattei, L., Marini, R., Balsemin, F., Urbano, M.D., Naio, R., Vicinelli, P., Arena, G., Mazzini, M., Gigli, N., Miserrafiti, B., Monopoli, A., Mortara, A., Delfino, P., Chioffi, M.M., Marino, P., Gravellone, M., Barbieri, L., Ledda, A., Carmina, M.G., Raisaro, A.E., Di Giacomo, C., Somaschini, A., Fasano, M.L., Sannazzaro, M., Arcieri, R., Pantaleoni, M., Leuzzi, C., Gorlato, G., Greco, G., Chiera, A., Ammaturo, T.A., Malanchini, G., Del Corral, M.P., Tedesco, L., Pede, S., Urso, L.G., Piscione, F., Galasso, G., Provasoli, S., Fattore, L., Lucca, G., Cresti, A., Cardillo, A., Fera, M.S., Vennettilli, F., Gaudio, C., Paravati, V., Caldarola, P., Locuratolo, N., Verlato, R., De Conti, F., Turiano, G., Preti, G., Moretti, L., Silenzi, S., Colonna, G., Picciolo, A., Nicosia, A., Cascone, C., Di Sciascio, G., Mangiacapra, F., Russo, A., Mastroianno, S., Esposito, G., Cosmi, F., D'Orazio, S., Costantini, C., Lanari, A., De Rosa, P., Esposito, L., Bilato, C., Valle, C Dalla, Ceresa, M., Colombo, E., Pennisi, V., Casciola, G., Driussi, M., Bisceglia, T., Scalvini, S., Rivadossi, F., Volpe, M., Comito, F., Scorzoni, D., Grimoldi, P., Lagioia, R., Santoro, D., De Cesare, N., Comotti, T., Poli, A., Martina, P., Musolino, M.F., Multari, E.I., Bilardo, G., Scalchi, G., Olivieri, C., Caranci, F., Pavan, D., Ganci, G., Mariani, A., Falchetti, E., Lanzillo, T., Caccavale, A., Bongo, A.S., Rizzi, A., Favilli, R., Maffei, S., Mallardo, M., Fulgione, C., Bordin, F., Bonmassari, R., Battaia, E., Puzzo, A., Vianello, G., D'Arpino, A., Romei, M., Pajes, G., Petronzelli, S., Ghezzi, F., Brigido, S., Pignatelli, L., Brscic, E., Sori, P., Russo, M., Biancolillo, E., Ignone, G., De Giorgio, N.A., Campaniello, C., Ponticelli, P., Margonato, A., Gerosa, S., Cutaia, A., Casalicchio, C., Bartolomucci, F., Larosa, C., Spadafina, T., Putignano, A., De Cristofaro, R., Bernardi, L., Sommariva, L., Celestini, A., Bertucci, C.M., Marchetti, M., Grisolia, E Franceschini, Ammendolea, C., Carini, M., Scipione, P., Politano, M., Rubino, G., Reina, C., Peccerillo, N., Paloscia, L., D'Alleva, A., Petacchi, R., Pignalosa, M., Lucchetti, D., Di Palma, F., La Mastra, R.A., Filippis, M De, Fontanella, B., Zanini, G., Casolo, G., Del Meglio, J., Parato, V.M., Genovesi, E., D'Alimonte, A., Miglioranza, A., Alessandri, N., Moscariello, F., Mauro, C., Sasso, A., Caso, P., Petrillo, C., Napoletano, C., Paparoni, S.R., Bernardo, V., Serdoz, R., Rotunno, R., Oppo, I., Aloisio, A., Aurelio, A., Licciardello, G., Cassaniti, L., Gulizia, M.M., Francese, G.M., Marcassa, C., Villani, R., Zorzoli, F., Mileto, F., Vecchis, M De, Scolozzi, D., Lupi, G., Caruso, D., Rebulla, E., La Fata, B., Anselmi, M., Girardi, P., Borruso, E., Ferrantelli, G., Sassone, B., Bressan, S., Capriolo, M., Pelissero, E., Piancastelli, M., Gobbi, M., Cocco, F., Bruno, M.G., Berti, S., Lo Surdo, G., Tanzi, P., De Rosa, R., Vilei, E., De Iaco, M.R., Grassi, G., Zanella, C., Marullo, L., Alfano, G., Pelaggi, P., Talarico, R., Tuccillo, B., Irace, L., Proietti, F., Di Croce, G., Di Lorenzo, L., Zarrilli, A., Bongini, M., Ranise, A., Aprile, A., Fornengo, C., Capogrosso, V., Tranghese, A., Golia, B., Marziano, A., Roncon, L., Picariello, C., Bagni, E., Leci, E., Gregorio, G., Gatto, F., Piemonte, F., Gervasio, F., Navazio, A., Guerri, E., Belmonte, E., Marino, F., Di Belardino, N., Di Nuzzo, M.R., Epifani, M., Comolatti, G., Conconi, B., Benea, D., Casu, G., Merella, P., Ammirati, M.A., Corrado, V.M., Spagnolo, D., Caico, S.I., Bonizzato, S., Margheri, M., Corrado, L., Antonicelli, R., Ferrigno, C., Merlino, A., Nassiacos, D., Antonelli, A., Marchese, A., Uguccioni, M., Villella, A., Bechi, S., Lo Bianco, F., Bedogni, F., Negro, L., Donato, L., Statile, D., Cassin, M., Fedele, F., Granatelli, A., Calcagno, S., Politi, A., Pani, A., De Luca, Leonardo, Temporelli, Pier Luigi, Gulizia, Michele Massimo, Gonzini, Lucio, Ammaturo, Tiziana Anita, Tedesco, Luigi, Pede, Silvia, Oliva, Fabrizio, Gabrielli, Domenico, Colivicchi, Furio, and Averna, Maurizio R.

Published
2023
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