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109. Body size and risk of non‐Hodgkin lymphoma by subtype: A pooled analysis from six prospective cohorts in the United States

Author

Teras, Lauren R., primary, Bertrand, Kimberly A., additional, Deubler, Emily L., additional, Chao, Chun R., additional, Lacey, James V., additional, Patel, Alpa V., additional, Rosner, Bernard A., additional, Shu, Yu‐Hsiang, additional, Wang, Ke, additional, Zhong, Charlie, additional, Wang, Sophia S., additional, and Birmann, Brenda M., additional

Published
2022
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112. Additional file 1 of The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density

Author

Ward, Sarah V., Burton, Anya, Tamimi, Rulla M., Pereira, Ana, Garmendia, Maria Luisa, Pollan, Marina, Boyd, Norman, dos-Santos-Silva, Isabel, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Bertrand, Kimberly, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Ma, Huiyan, Vinnicombe, Sarah, Moss, Sue, Allen, Steve, Ndumia, Rose, Vinayak, Sudhir, Teo, Soo-Hwang, Mariapun, Shivaani, Peplonska, Beata, Bukowska-Damska, Agnieszka, Nagata, Chisato, Hopper, John, Giles, Graham, Ozmen, Vahit, Aribal, Mustafa Erkin, Schüz, Joachim, Van Gils, Carla H., Wanders, Johanna O. P., Sirous, Reza, Sirous, Mehri, Hipwell, John, Kim, Jisun, Lee, Jong Won, Dickens, Caroline, Hartman, Mikael, Chia, Kee-Seng, Scott, Christopher, Chiarelli, Anna M., Linton, Linda, Flugelman, Anath Arzee, Salem, Dorria, Kamal, Rasha, McCormack, Valerie, and Stone, Jennifer

Abstract

Additional file 1. Tables S1 and S2: Supplementary data providing results from sensitivity analyses of pooled models adjusted for a population-specific weight-for-height index instead of BMI

Published
2022
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114. Maximum and Time-Dependent Body Mass Index and Breast Cancer Incidence Among Postmenopausal Women in the Black Women’s Health Study

Author

Gathirua-Mwangi, Wambui G, primary, Palmer, Julie R, additional, Champion, Victoria, additional, Castro-Webb, Nelsy, additional, Stokes, Andrew C, additional, Adams-Campbell, Lucile, additional, Marley, Andrew R, additional, Forman, Michele R, additional, Rosenberg, Lynn, additional, and Bertrand, Kimberly A, additional

Published
2022
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115. Polygenic Risk Scores for Prediction of Breast Cancer Risk in Women of African Ancestry: a Cross-Ancestry Approach

Author

Gao, Guimin, primary, Zhao, Fangyuan, additional, Ahearn, Thomas, additional, Lunetta, Kathryn L., additional, Troester, Melissa A., additional, Du, Zhaohui, additional, Ogundiran, Temidayo O., additional, Ojengbede, Oladosu, additional, Blot, William, additional, Nathanson, Katherine L., additional, Domchek, Susan M., additional, Nemesure, Barbara, additional, Hennis, Anselm, additional, Ambs, Stefan, additional, McClellan, Julian, additional, Nie, Mark, additional, Bertrand, Kimberly, additional, Zirpoli, Gary, additional, Yao, Song, additional, Olshan, Andrew F., additional, Bensen, Jeannette T., additional, Bandera, Elisa V., additional, Nyante, Sarah, additional, Conti, David V., additional, Press, Michael F., additional, Ingles, Sue A., additional, John, Esther M., additional, Bernstein, Leslie, additional, Hu, Jennifer J., additional, Deming-Halverson, Sandra L., additional, Chanock, Stephen J., additional, Ziegler, Regina G., additional, Rodriguez-Gil, Jorge L., additional, Sucheston-Campbell, Lara E., additional, Sandler, Dale P., additional, Taylor, Jack A., additional, Kitahara, Cari M., additional, O'Brien, Katie M., additional, Bolla, Manjeet K., additional, Dennis, Joe, additional, Dunning, Alison, additional, Easton, Douglas F., additional, Michailidou, Kyriaki, additional, Pharoah, Paul D.P., additional, Wang, Qin, additional, Figueroa, Jonine, additional, Biritwum, Richard, additional, Adjei, Ernest, additional, Wiafe, Seth, additional, Ambrosone, Christine B., additional, Zheng, Wei, additional, Olopade, Olufunmilayo I., additional, García-Closas, Montserrat, additional, Palmer, Julie R., additional, Haiman, Christopher A., additional, and Huo, Dezheng, additional

Published
2021
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117. A Validated Risk Prediction Model for Breast Cancer in US Black Women

Author

Palmer, Julie R., primary, Zirpoli, Gary, additional, Bertrand, Kimberly A., additional, Battaglia, Tracy, additional, Bernstein, Leslie, additional, Ambrosone, Christine B., additional, Bandera, Elisa V., additional, Troester, Melissa A., additional, Rosenberg, Lynn, additional, Pfeiffer, Ruth M., additional, and Trinquart, Ludovic, additional

Published
2021
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120. Risk of Late-Onset Breast Cancer in Genetically Predisposed Women

Author

Boddicker, Nicholas J., primary, Hu, Chunling, additional, Weitzel, Jeffrey N., additional, Kraft, Peter, additional, Nathanson, Katherine L., additional, Goldgar, David E., additional, Na, Jie, additional, Huang, Hongyan, additional, Gnanaolivu, Rohan D., additional, Larson, Nicole, additional, Yussuf, Amal, additional, Yao, Song, additional, Vachon, Celine M., additional, Trentham-Dietz, Amy, additional, Teras, Lauren, additional, Taylor, Jack A., additional, Scott, Christopher E., additional, Sandler, Dale P., additional, Pesaran, Tina, additional, Patel, Alpa V., additional, Palmer, Julie R., additional, Ong, Irene M., additional, Olson, Janet E., additional, O'Brien, Katie, additional, Neuhausen, Susan, additional, Martinez, Elena, additional, Ma, Huiyan, additional, Lindstrom, Sara, additional, Le Marchand, Loic, additional, Kooperberg, Charles, additional, Karam, Rachid, additional, Hunter, David J., additional, Hodge, James M., additional, Haiman, Christopher, additional, Gaudet, Mia M., additional, Gao, Chi, additional, LaDuca, Holly, additional, Lacey, James V., additional, Dolinsky, Jill S., additional, Chao, Elizabeth, additional, Carter, Brian D., additional, Burnside, Elizabeth S., additional, Bertrand, Kimberly A., additional, Bernstein, Leslie, additional, Auer, Paul W., additional, Ambrosone, Christine, additional, Yadav, Siddhartha, additional, Hart, Steven N., additional, Polley, Eric C., additional, Domchek, Susan M., additional, and Couch, Fergus J., additional

Published
2021
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121. Persistent organic pollutants and type 2 diabetes: a prospective analysis in the Nurses' health study and meta-analysis

Author

Wu, Hongyu, Bertrand, Kimberly A., Choi, Anna L., Hu, Frank B., Laden, Francine, Grandjean, Philippe, and Sun, Qi

Subjects
Persistent organic pollutants -- Health aspects, Environmentally induced diseases -- Research -- Risk factors, Type 2 diabetes -- Analysis -- Genetic aspects -- Risk factors, Environmental issues, Health
Abstract

The prevalence of type 2 diabetes (T2D) is increasing rapidly worldwide, and this disease has posed an enormous public health challenge. It is widely considered that complex interactions between genetic [...]

Published
2013

123. Gestational diabetes and risk of breast cancer before age 55 years

Author

Bertrand, Kimberly A, primary, O’Brien, Katie M, additional, Wright, Lauren B, additional, Palmer, Julie R, additional, Blot, William J, additional, Eliassen, A Heather, additional, Rosenberg, Lynn, additional, Sandin, Sven, additional, Tobias, Deirdre, additional, Weiderpass, Elisabete, additional, Zheng, Wei, additional, Swerdlow, Anthony J, additional, Schoemaker, Minouk J, additional, Nichols, Hazel B, additional, and Sandler, Dale P, additional

Published
2021
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125. Prenatal Diethylstilbestrol Exposure and Cancer Risk in Males

Author

Strohsnitter, William C., primary, Hyer, Marianne, additional, Bertrand, Kimberly A., additional, Cheville, Andrea L., additional, Palmer, Julie R., additional, Hatch, Elizabeth E., additional, Aagaard, Kjersti M., additional, Titus, Linda, additional, Romero, Iris L., additional, Huo, Dezheng, additional, Hoover, Robert N., additional, and Troisi, Rebecca, additional

Published
2021
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126. Additional file 1 of Neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women

Author

Barber, Lauren E., Zirpoli, Gary R., Cozier, Yvette C., Rosenberg, Lynn, Petrick, Jessica L., Bertrand, Kimberly A., and Palmer, Julie R.

Abstract

Additional file 1: Table S1. Distributions of the factors that contribute to neighborhood SES and neighborhood concentrated disadvantage scores, at baseline in 1995.

Published
2021
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130. The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.

Author

Ward, Sarah V., Burton, Anya, Tamimi, Rulla M., Pereira, Ana, Garmendia, Maria Luisa, Pollan, Marina, Boyd, Norman, dos-Santos-Silva, Isabel, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Bertrand, Kimberly, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Ma, Huiyan, and Vinnicombe, Sarah

Subjects
MENARCHE, BODY mass index, DENSITY, BODY size, DISEASE risk factors
Abstract

Background: Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of breast cancer risk.Methods: Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (√PD) and dense area (√DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, body mass index, menopausal status, hormone therapy use, mammography view and type, mammographic density assessor, parity and height/age at menarche.Results: In pooled analyses, later age at menarche was associated with higher per cent density (β√PD = 0.023 SE = 0.008, P = 0.003) and larger dense area (β√DA = 0.032 SE = 0.010, P = 0.002). Taller women had larger dense area (β√DA = 0.069 SE = 0.028, P = 0.012) and higher per cent density (β√PD = 0.044, SE = 0.023, P = 0.054), although the observed effect on per cent density depended upon the adjustment used for body size. Similar overall effect estimates were observed in meta-analyses across population groups.Conclusions: In one of the largest international studies to date, later age at menarche was positively associated with mammographic density. This is in contrast to its association with breast cancer risk, providing little evidence of mediation. Increased height was also positively associated with mammographic density, particularly dense area. These results suggest a complex relationship between growth and development, mammographic density and breast cancer risk. Future studies should evaluate the potential mediation of the breast cancer effects of taller stature through absolute breast density. [ABSTRACT FROM AUTHOR]

Published
2022
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131. Hypertensive diseases of pregnancy and risk of breast cancer in the Black Women's Health Study.

Author

Bigham, Zahna, Robles, Yvonne, Freund, Karen M., Palmer, Julie R., and Bertrand, Kimberly A.

Abstract

Purpose: Compared to white women, Black women have increased risk of developing hypertensive diseases of pregnancy (HDOP) and have a higher incidence of aggressive breast cancer subtypes. Few studies of HDOP and breast cancer risk have included large numbers of Black women. This study examined the relation of HDOP to incidence of breast cancer overall and by estrogen receptor (ER) status in Black women. Methods: We followed 42,982 parous women in the Black Women's Health Study, a nationwide prospective study of Black women. Multivariable Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) to assess associations of self-reported HDOP, including preeclampsia and gestational hypertension, with breast cancer incidence overall and by ER subtype, adjusted for age and established breast cancer risk factors. Results: Over 20 years of follow-up, we identified 2376 incident breast cancer cases. History of HDOP (11.7%) was not associated with breast cancer risk overall (HR 0.98; 95% CI 0.87, 1.11). HRs for invasive ER+ and ER– breast cancer were 1.11 (95% CI 0.93, 1.34) and 0.81 (95% CI 0.61, 1.07), respectively. Conclusions: HDOP was not associated with risk of overall breast cancer in Black women. A suggestive inverse association with ER– breast cancer may reflect an anti-tumorigenic hormone profile in HDOP, but those results require confirmation in other studies. [ABSTRACT FROM AUTHOR]

Published
2022
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133. Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide

Author

Burton, Anya, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Rice, Megan, Pereira, Ana, Garmendia, Maria Luisa, Tamimi, Rulla M., Bertrand, Kimberly, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Qureshi, Samera A., Ma, Huiyan, Vinnicombe, Sarah, Moss, Sue, Allen, Steve, Ndumia, Rose, Vinayak, Sudhir, Teo, Soo-Hwang, Mariapun, Shivaani, Fadzli, Farhana, Peplonska, Beata, Bukowska, Agnieszka, Nagata, Chisato, Stone, Jennifer, Hopper, John, Giles, Graham, Ozmen, Vahit, Aribal, Mustafa Erkin, Schüz, Joachim, Van Gils, Carla H., Wanders, Johanna O. P., Sirous, Reza, Sirous, Mehri, Hipwell, John, Kim, Jisun, Lee, Jong Won, Dickens, Caroline, Hartman, Mikael, Chia, Kee-Seng, Scott, Christopher, Chiarelli, Anna M., Linton, Linda, Pollan, Marina, Flugelman, Anath Arzee, Salem, Dorria, Kamal, Rasha, Boyd, Norman, dos-Santos-Silva, Isabel, and McCormack, Valerie

Subjects
Mammography -- Usage, Postmenopausal women -- Health aspects, Body mass index -- Measurement, Biological sciences
Abstract

Background Mammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have been studied in women in western countries, but whether these associations apply to women worldwide is not known. Methods and findings We examined cross-sectional differences in MD by age and menopausal status in over 11,000 breast-cancer-free women aged 35-85 years, from 40 ethnicity- and location-specific population groups across 22 countries in the International Consortium on Mammographic Density (ICMD). MD was read centrally using a quantitative method (Cumulus) and its square-root metrics were analysed using meta-analysis of group-level estimates and linear regression models of pooled data, adjusted for body mass index, reproductive factors, mammogram view, image type, and reader. In all, 4,534 women were premenopausal, and 6,481 postmenopausal, at the time of mammography. A large age-adjusted difference in percent MD (PD) between post- and premenopausal women was apparent (-0.46 cm [95% CI: -0.53, -0.39]) and appeared greater in women with lower breast cancer risk profiles; variation across population groups due to heterogeneity (I.sup.2) was 16.5%. Among premenopausal women, the [square root]PD difference per 10-year increase in age was -0.24 cm (95% CI: -0.34, -0.14; I.sup.2 = 30%), reflecting a compositional change (lower dense area and higher non-dense area, with no difference in breast area). In postmenopausal women, the corresponding difference in [square root]PD (-0.38 cm [95% CI: -0.44, -0.33]; I.sup.2 = 30%) was additionally driven by increasing breast area. The study is limited by different mammography systems and its cross-sectional rather than longitudinal nature. Conclusions Declines in MD with increasing age are present premenopausally, continue postmenopausally, and are most pronounced over the menopausal transition. These effects were highly consistent across diverse groups of women worldwide, suggesting that they result from an intrinsic biological, likely hormonal, mechanism common to women. If cumulative breast density is a key determinant of breast cancer risk, younger ages may be the more critical periods for lifestyle modifications aimed at breast density and breast cancer risk reduction., Author(s): Anya Burton 1, Gertraud Maskarinec 2, Beatriz Perez-Gomez 3,4, Celine Vachon 5, Hui Miao 6, Martín Lajous 7, Ruy López-Ridaura 7, Megan Rice 8, Ana Pereira 9, Maria Luisa [...]

Published
2017
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134. Adult weight change and premenopausal breast cancer risk : A prospective pooled analysis of data from 628,463 women

Author

Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie-Christine, Chen, Yu, Connor, Avonne E., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Ma, Huiyan, Milne, Roger L., Ozasa, Kotaro, Palmer, Julie R., Riboli, Elio, Rohan, Thomas E., Sacerdote, Carlotta, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., Swerdlow, Anthony J., Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie-Christine, Chen, Yu, Connor, Avonne E., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Ma, Huiyan, Milne, Roger L., Ozasa, Kotaro, Palmer, Julie R., Riboli, Elio, Rohan, Thomas E., Sacerdote, Carlotta, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., and Swerdlow, Anthony J.

Abstract

Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18-24 years and other breast cancer risk factors showed that weight gain from ages 18-24 to 35-44 or to 45-54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.95-0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.94-0.98). Weight gain from ages 25-34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35-44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45-54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.

Published
2020
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135. Contribution of socioeconomic and environmental factors to geographic disparities in breast cancer risk in the Nurses' Health Study II.

Author

Vieira, Verónica M, Vieira, Verónica M, VoPham, Trang, Bertrand, Kimberly A, James, Peter, DuPré, Natalie, Tamimi, Rulla M, Laden, Francine, Hart, Jaime E, Vieira, Verónica M, Vieira, Verónica M, VoPham, Trang, Bertrand, Kimberly A, James, Peter, DuPré, Natalie, Tamimi, Rulla M, Laden, Francine, and Hart, Jaime E

Abstract

BackgroundEvidence of geographic disparities in breast cancer incidence within the U.S. and spatial analyses can provide insight into the potential contribution of environmental exposures or other geographically-varying factors to these disparities.MethodsWe applied generalized additive models (GAMs) to smooth geocoded residential coordinates while adjusting for covariates. Our analysis included 3,478 breast cancer cases among 24,519 control women from the Nurses' Health Study II (NHSII). We first examined associations with residential location during adolescence (high school address) or early adulthood (address in 1991). We then assessed the contribution from known individual-level risk factors, measures of socioeconomic status (SES), and occupational and environmental factors that vary spatially and have been linked to breast cancer. Secondary analyses by estrogen receptor (ER) and menopausal status were also conducted.ResultsWe identified geographic patterns of breast cancer risk associated with location during adolescence, with increased risk apparent in Michigan, the Northwest, and the New York City area, that shifted to southern New England when addresses during early adulthood were analyzed. Similar results were observed after adjustment for individual- and area-level factors, although spatial associations were no longer statistically significant.ConclusionBreast cancer risk is not spatially uniform across the U.S. and incidence patterns varied depending on the timing during life of the residence considered. Geographic disparities persisted even after accounting for established and suspected breast cancer risk factors, suggesting that unmeasured environmental or lifestyle risk factors may explain geographic variation in risk in different parts of the country.

Published
2020

136. Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women.

Author

Palmer, Julie R, Palmer, Julie R, Polley, Eric C, Hu, Chunling, John, Esther M, Haiman, Christopher, Hart, Steven N, Gaudet, Mia, Pal, Tuya, Anton-Culver, Hoda, Trentham-Dietz, Amy, Bernstein, Leslie, Ambrosone, Christine B, Bandera, Elisa V, Bertrand, Kimberly A, Bethea, Traci N, Gao, Chi, Gnanaolivu, Rohan D, Huang, Hongyan, Lee, Kun Y, LeMarchand, Loic, Na, Jie, Sandler, Dale P, Shah, Payal D, Yadav, Siddhartha, Yang, William, Weitzel, Jeffrey N, Domchek, Susan M, Goldgar, David E, Nathanson, Katherine L, Kraft, Peter, Yao, Song, Couch, Fergus J, Palmer, Julie R, Palmer, Julie R, Polley, Eric C, Hu, Chunling, John, Esther M, Haiman, Christopher, Hart, Steven N, Gaudet, Mia, Pal, Tuya, Anton-Culver, Hoda, Trentham-Dietz, Amy, Bernstein, Leslie, Ambrosone, Christine B, Bandera, Elisa V, Bertrand, Kimberly A, Bethea, Traci N, Gao, Chi, Gnanaolivu, Rohan D, Huang, Hongyan, Lee, Kun Y, LeMarchand, Loic, Na, Jie, Sandler, Dale P, Shah, Payal D, Yadav, Siddhartha, Yang, William, Weitzel, Jeffrey N, Domchek, Susan M, Goldgar, David E, Nathanson, Katherine L, Kraft, Peter, Yao, Song, and Couch, Fergus J

Abstract

BackgroundThe risks of breast cancer in African American (AA) women associated with inherited mutations in breast cancer predisposition genes are not well defined. Thus, whether multigene germline hereditary cancer testing panels are applicable to this population is unknown. We assessed associations between mutations in panel-based genes and breast cancer risk in 5054 AA women with breast cancer and 4993 unaffected AA women drawn from 10 epidemiologic studies.MethodsGermline DNA samples were sequenced for mutations in 23 cancer predisposition genes using a QIAseq multiplex amplicon panel. Prevalence of mutations and odds ratios (ORs) for associations with breast cancer risk were estimated with adjustment for study design, age, and family history of breast cancer.ResultsPathogenic mutations were identified in 10.3% of women with estrogen receptor (ER)-negative breast cancer, 5.2% of women with ER-positive breast cancer, and 2.3% of unaffected women. Mutations in BRCA1, BRCA2, and PALB2 were associated with high risks of breast cancer (OR = 47.55, 95% confidence interval [CI] = 10.43 to >100; OR = 7.25, 95% CI = 4.07 to 14.12; OR = 8.54, 95% CI = 3.67 to 24.95, respectively). RAD51D mutations were associated with high risk of ER-negative disease (OR = 7.82, 95% CI = 1.61 to 57.42). Moderate risks were observed for CHEK2, ATM, ERCC3, and FANCC mutations with ER-positive cancer, and RECQL mutations with all breast cancer.ConclusionsThe study identifies genes that predispose to breast cancer in the AA population, demonstrates the validity of current breast cancer testing panels for use in AA women, and provides a basis for increased referral of AA patients for cancer genetic testing.

Published
2020

137. Dioxin exposure and breast cancer risk in a prospective cohort study.

Author

VoPham, Trang, VoPham, Trang, Bertrand, Kimberly A, Jones, Rena R, Deziel, Nicole C, DuPré, Natalie C, James, Peter, Liu, Ying, Vieira, Verónica M, Tamimi, Rulla M, Hart, Jaime E, Ward, Mary H, Laden, Francine, VoPham, Trang, VoPham, Trang, Bertrand, Kimberly A, Jones, Rena R, Deziel, Nicole C, DuPré, Natalie C, James, Peter, Liu, Ying, Vieira, Verónica M, Tamimi, Rulla M, Hart, Jaime E, Ward, Mary H, and Laden, Francine

Abstract

BackgroundDioxins are persistent organic pollutants generated from industrial combustion processes such as waste incineration. To date, results from epidemiologic studies of dioxin exposure and breast cancer risk have been mixed.ObjectivesTo prospectively examine the association between ambient dioxin exposure using a nationwide spatial database of industrial dioxin-emitting facilities and invasive breast cancer risk in the Nurses' Health Study II (NHSII).MethodsNHSII includes female registered nurses in the US who have completed self-administered biennial questionnaires since 1989. Incident invasive breast cancer diagnoses were self-reported and confirmed by medical record review. Dioxin exposure was estimated based on residential proximity, duration of residence, and emissions from facilities located within 3, 5, and 10 km around geocoded residential addresses updated throughout follow-up. Cox regression models adjusted for breast cancer risk factors were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsFrom 1989 to 2013, 3840 invasive breast cancer cases occurred among 112,397 participants. There was no association between residential proximity to any dioxin facilities (all facilities combined) and breast cancer risk overall. However, women who resided within 10 km of any municipal solid waste incinerator (MSWI) compared to none had increased breast cancer risk (adjusted HR = 1.15, 95% CI: 1.03, 1.28), with stronger associations noted for women who lived within 5 km (adjusted HR = 1.25, 95% CI: 1.04, 1.52). Positive associations were also observed for longer duration of residence and higher dioxin emissions from MSWIs within 3, 5, and 10 km. There were no clear differences in patterns of association for ER + vs. ER-breast cancer or by menopausal status.DiscussionResults from this study support positive associations between dioxin exposure from MSWIs and invasive breast cancer risk.

Published
2020

138. Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women.

Author

Palmer, Julie, Palmer, Julie, Polley, Eric, Hu, Chunling, John, Esther, Haiman, Christopher, Hart, Steven, Gaudet, Mia, Pal, Tuya, Trentham-Dietz, Amy, Bernstein, Leslie, Ambrosone, Christine, Bandera, Elisa, Bertrand, Kimberly, Bethea, Traci, Gao, Chi, Gnanaolivu, Rohan, Huang, Hongyan, Lee, Kun, LeMarchand, Loic, Na, Jie, Sandler, Dale, Shah, Payal, Yadav, Siddhartha, Yang, William, Weitzel, Jeffrey, Domchek, Susan, Goldgar, David, Nathanson, Katherine, Kraft, Peter, Yao, Song, Couch, Fergus, Anton-Culver, Hoda, Palmer, Julie, Palmer, Julie, Polley, Eric, Hu, Chunling, John, Esther, Haiman, Christopher, Hart, Steven, Gaudet, Mia, Pal, Tuya, Trentham-Dietz, Amy, Bernstein, Leslie, Ambrosone, Christine, Bandera, Elisa, Bertrand, Kimberly, Bethea, Traci, Gao, Chi, Gnanaolivu, Rohan, Huang, Hongyan, Lee, Kun, LeMarchand, Loic, Na, Jie, Sandler, Dale, Shah, Payal, Yadav, Siddhartha, Yang, William, Weitzel, Jeffrey, Domchek, Susan, Goldgar, David, Nathanson, Katherine, Kraft, Peter, Yao, Song, Couch, Fergus, and Anton-Culver, Hoda

Abstract

BACKGROUND: The risks of breast cancer in African American (AA) women associated with inherited mutations in breast cancer predisposition genes are not well defined. Thus, whether multigene germline hereditary cancer testing panels are applicable to this population is unknown. We assessed associations between mutations in panel-based genes and breast cancer risk in 5054 AA women with breast cancer and 4993 unaffected AA women drawn from 10 epidemiologic studies. METHODS: Germline DNA samples were sequenced for mutations in 23 cancer predisposition genes using a QIAseq multiplex amplicon panel. Prevalence of mutations and odds ratios (ORs) for associations with breast cancer risk were estimated with adjustment for study design, age, and family history of breast cancer. RESULTS: Pathogenic mutations were identified in 10.3% of women with estrogen receptor (ER)-negative breast cancer, 5.2% of women with ER-positive breast cancer, and 2.3% of unaffected women. Mutations in BRCA1, BRCA2, and PALB2 were associated with high risks of breast cancer (OR = 47.55, 95% confidence interval [CI] = 10.43 to >100; OR = 7.25, 95% CI = 4.07 to 14.12; OR = 8.54, 95% CI = 3.67 to 24.95, respectively). RAD51D mutations were associated with high risk of ER-negative disease (OR = 7.82, 95% CI = 1.61 to 57.42). Moderate risks were observed for CHEK2, ATM, ERCC3, and FANCC mutations with ER-positive cancer, and RECQL mutations with all breast cancer. CONCLUSIONS: The study identifies genes that predispose to breast cancer in the AA population, demonstrates the validity of current breast cancer testing panels for use in AA women, and provides a basis for increased referral of AA patients for cancer genetic testing.

Published
2020

139. A Population-Based Study of Genes Previously Implicated in Breast Cancer

Author

Hu, Chunling, primary, Hart, Steven N., additional, Gnanaolivu, Rohan, additional, Huang, Hongyan, additional, Lee, Kun Y., additional, Na, Jie, additional, Gao, Chi, additional, Lilyquist, Jenna, additional, Yadav, Siddhartha, additional, Boddicker, Nicholas J., additional, Samara, Raed, additional, Klebba, Josh, additional, Ambrosone, Christine B., additional, Anton-Culver, Hoda, additional, Auer, Paul, additional, Bandera, Elisa V., additional, Bernstein, Leslie, additional, Bertrand, Kimberly A., additional, Burnside, Elizabeth S., additional, Carter, Brian D., additional, Eliassen, Heather, additional, Gapstur, Susan M., additional, Gaudet, Mia, additional, Haiman, Christopher, additional, Hodge, James M., additional, Hunter, David J., additional, Jacobs, Eric J., additional, John, Esther M., additional, Kooperberg, Charles, additional, Kurian, Allison W., additional, Le Marchand, Loic, additional, Lindstroem, Sara, additional, Lindstrom, Tricia, additional, Ma, Huiyan, additional, Neuhausen, Susan, additional, Newcomb, Polly A., additional, O’Brien, Katie M., additional, Olson, Janet E., additional, Ong, Irene M., additional, Pal, Tuya, additional, Palmer, Julie R., additional, Patel, Alpa V., additional, Reid, Sonya, additional, Rosenberg, Lynn, additional, Sandler, Dale P., additional, Scott, Christopher, additional, Tamimi, Rulla, additional, Taylor, Jack A., additional, Trentham-Dietz, Amy, additional, Vachon, Celine M., additional, Weinberg, Clarice, additional, Yao, Song, additional, Ziogas, Argyrios, additional, Weitzel, Jeffrey N., additional, Goldgar, David E., additional, Domchek, Susan M., additional, Nathanson, Katherine L., additional, Kraft, Peter, additional, Polley, Eric C., additional, and Couch, Fergus J., additional

Published
2021
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140. Red blood cell membrane trans fatty acid levels and risk of non-Hodgkin lymphoma: a prospective nested case–control study

Author

Ardisson Korat, Andres V, primary, Chiu, Yu-Han, additional, Bertrand, Kimberly A, additional, Zhang, Shumin, additional, Epstein, Mara M, additional, Rosner, Bernard A, additional, Chiuve, Stephanie, additional, Campos, Hannia, additional, Giovannucci, Edward L, additional, Chavarro, Jorge E, additional, and Birmann, Brenda M, additional

Published
2020
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146. Dioxin exposure and breast cancer risk in a prospective cohort study

Author

VoPham, Trang, primary, Bertrand, Kimberly A., additional, Jones, Rena R., additional, Deziel, Nicole C., additional, DuPré, Natalie C., additional, James, Peter, additional, Liu, Ying, additional, Vieira, Verónica M., additional, Tamimi, Rulla M., additional, Hart, Jaime E., additional, Ward, Mary H., additional, and Laden, Francine, additional

Published
2020
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149. Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women

Author

Palmer, Julie R, primary, Polley, Eric C, additional, Hu, Chunling, additional, John, Esther M, additional, Haiman, Christopher, additional, Hart, Steven N, additional, Gaudet, Mia, additional, Pal, Tuya, additional, Anton-Culver, Hoda, additional, Trentham-Dietz, Amy, additional, Bernstein, Leslie, additional, Ambrosone, Christine B, additional, Bandera, Elisa V, additional, Bertrand, Kimberly A, additional, Bethea, Traci N, additional, Gao, Chi, additional, Gnanaolivu, Rohan D, additional, Huang, Hongyan, additional, Lee, Kun Y, additional, LeMarchand, Loic, additional, Na, Jie, additional, Sandler, Dale P, additional, Shah, Payal D, additional, Yadav, Siddhartha, additional, Yang, William, additional, Weitzel, Jeffrey N, additional, Domchek, Susan M, additional, Goldgar, David E, additional, Nathanson, Katherine L, additional, Kraft, Peter, additional, Yao, Song, additional, and Couch, Fergus J, additional

Published
2020
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150. Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women

Author

Schoemaker, Minouk J., primary, Nichols, Hazel B., additional, Wright, Lauren B., additional, Brook, Mark N., additional, Jones, Michael E., additional, O'Brien, Katie M., additional, Adami, Hans‐Olov, additional, Baglietto, Laura, additional, Bernstein, Leslie, additional, Bertrand, Kimberly A., additional, Boutron‐Ruault, Marie‐Christine, additional, Chen, Yu, additional, Connor, Avonne E., additional, Dossus, Laure, additional, Eliassen, A. Heather, additional, Giles, Graham G., additional, Gram, Inger T., additional, Hankinson, Susan E., additional, Kaaks, Rudolf, additional, Key, Timothy J., additional, Kirsh, Victoria A., additional, Kitahara, Cari M., additional, Larsson, Susanna C., additional, Linet, Martha, additional, Ma, Huiyan, additional, Milne, Roger L., additional, Ozasa, Kotaro, additional, Palmer, Julie R., additional, Riboli, Elio, additional, Rohan, Thomas E., additional, Sacerdote, Carlotta, additional, Sadakane, Atsuko, additional, Sund, Malin, additional, Tamimi, Rulla M., additional, Trichopoulou, Antonia, additional, Ursin, Giske, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Willett, Walter C., additional, Wolk, Alicja, additional, Zeleniuch‐Jacquotte, Anne, additional, Sandler, Dale P., additional, and Swerdlow, Anthony J., additional

Published
2020
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