530 results on '"Berkhemer, Olvert A"'
Search Results
102. Importance of Occlusion Site for Thrombectomy Technique in Stroke
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Bernsen, Marie Louise E., primary, Goldhoorn, Robert-Jan B., additional, Lingsma, Hester F., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Uyttenboogaart, Maarten, additional, Roos, Yvo B.W.E.M., additional, Martens, Jasper M., additional, Hofmeijer, Jeannette, additional, Dippel, Diederik W.J., additional, van der Lugt, Aad, additional, Majoie, Charles B.L.M., additional, Boiten, Jelis, additional, Albert Vos, Jan, additional, Jansen, Ivo G.H., additional, Mulder, Maxim J.H.L., additional, Goldhoorn, Robert- Jan B., additional, Compagne, Kars C.J., additional, Kappelhof, Manon, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, Roozenbeek, Bob, additional, van Es, Adriaan C.G.M., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Schonewille, Wouter J., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, Lycklama, Geert J., additional, Nijeholt, à, additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, Vries, J. de, additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Bulut, Tomas, additional, Brouwers, Paul J.A.M., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, der Kallen, Bas F.W. van, additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine L., additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional
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- 2021
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103. Combined Effect of Age and Baseline Alberta Stroke Program Early Computed Tomography Score on Post-Thrombectomy Clinical Outcomes in the MR CLEAN Registry
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Ospel, Johanna, primary, Kappelhof, Manon, additional, Groot, Adrien E., additional, LeCouffe, Natalie E., additional, Coutinho, Jonathan M., additional, Yoo, Albert J., additional, Yo, Lonneke S.F., additional, Beenen, Ludo F.M., additional, van Zwam, Wim H., additional, van der Lugt, Aad, additional, Postma, Alida A., additional, Roos, Yvo B.W.E.M., additional, Goyal, Mayank, additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, van Oostenbrugge, Robert J., additional, Boiten, Jelis, additional, Albert Vos, Jan, additional, Jansen, Ivo G.H., additional, Mulder, Maxim J.H.L., additional, Goldhoorn, Robert- Jan B., additional, Compagne, Kars C.J., additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, Roozenbeek, Bob, additional, van Es, Adriaan C.G.M., additional, Emmer, Bart J., additional, Schonewille, Wouter J., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul J.A.M., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, Lingsma, Hester F., additional, Ghannouti, Naziha el, additional, Sterrenberg, Martin, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Schupp, Lieve M., additional, Voogd, Eva J.H.F., additional, Collette, Sabine, additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional
- Published
- 2020
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104. Arterial Steal to the Penumbra Area in Patients with Acute MCA Occlusion: A Quantitative Angiographic Analysis
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van den Berg, René, primary, Wildeman, Jenna J., additional, Berkhemer, Olvert A., additional, Immink, Rogier V., additional, Marquering, Henk A., additional, Majoie, Charles B.L.M., additional, Verbaan, Dagmar, additional, and van Bavel, Ed T., additional
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- 2020
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105. Admission Blood Pressure in Relation to Clinical Outcomes and Successful Reperfusion After Endovascular Stroke Treatment
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van den Berg, Sophie A., primary, Uniken Venema, Simone M., additional, Mulder, Maxim J.H.L., additional, Treurniet, Kilian M., additional, Samuels, Noor, additional, Lingsma, Hester F., additional, Goldhoorn, Robert-Jan B., additional, Jansen, Ivo G.H., additional, Coutinho, Jonathan M., additional, Roozenbeek, Bob, additional, Dippel, Diederik W.J., additional, Roos, Yvo B.W.E.M., additional, van der Worp, H. Bart, additional, Nederkoorn, Paul J., additional, van der Lugt, Aad, additional, Majoie, Charles B.L.M., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Vos, Jan Albert, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, Kappelhof, Manon, additional, Compagne, Kars C.J., additional, van Es, Adriaan C.G.M., additional, Emmer, Bart J., additional, Schonewille, Wouter J., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Vries, J., additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul, additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, Ghannouti, Naziha el, additional, Sterrenberg, Martin, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, van Rijswijk, Cathelijn, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Khalilzada, Mostafa, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine, additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional
- Published
- 2020
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106. A Convolutional Neural Network for Anterior Intra-Arterial Thrombus Detection and Segmentation on Non-Contrast Computed Tomography of Patients with Acute Ischemic Stroke
- Author
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Tolhuisen, Manon L., primary, Ponomareva, Elena, additional, Boers, Anne M. M., additional, Jansen, Ivo G. H., additional, Koopman, Miou S., additional, Sales Barros, Renan, additional, Berkhemer, Olvert A., additional, van Zwam, Wim H., additional, van der Lugt, Aad, additional, Majoie, Charles B. L. M., additional, and Marquering, Henk A., additional
- Published
- 2020
- Full Text
- View/download PDF
107. Path From Clinical Research to Implementation
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Wiegers, Eveline J.A., primary, Compagne, Kars C.J., additional, Janssen, Paula M., additional, Venema, Esmee, additional, Deckers, Jaap W., additional, Schonewille, Wouter J., additional, Albert Vos, Jan, additional, Lycklama à Nijeholt, Geert J., additional, Roozenbeek, Bob, additional, Martens, Jasper M., additional, Hofmeijer, Jeannette, additional, van Oostenbrugge, Robert-Jan, additional, van Zwam, Wim H., additional, Majoie, Charles B.L.M., additional, van der Lugt, Aad, additional, Lingsma, H.F., additional, Roos, Yvo B.W.E.M., additional, Dippel, Diederik W.J., additional, Boiten, Jelis, additional, Brouwer, Josje, additional, den Hartog, Sanne J., additional, Hinsenveld, Wouter H., additional, Kappelhof, Manon, additional, Goldhoorn, Robert-Jan B., additional, Mulder, Maxim J.H.L., additional, Jansen, Ivo G.H., additional, van Es, Adriaan C.G.M., additional, Emmer, Bart J., additional, Coutinho, Jonathan M., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, Vries, J. de, additional, de Kort, Paul L.M., additional, van Tuijl, Julia, additional, Peluso, Jo Jo P., additional, Fransen, Puck, additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eschgi, Omid, additional, Bokkers, Reinoud P.H., additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Brouwers, Paul, additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, van den Wijngaard, Ido R., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Meijer, Anton, additional, Ghariq, Elyas, additional, van Proosdij, Marc P., additional, Krietemeijer, G. Menno, additional, Peluso, Jo P., additional, Lo, Rob, additional, Gerrits, Dick, additional, Dinkelaar, Wouter, additional, Appelman, Auke P.A., additional, Hammer, Bas, additional, Pegge, Sjoert, additional, van der Hoorn, Anouk, additional, Vinke, Saman, additional, Flach, H. Zwenneke, additional, Ghannouti, Naziha el, additional, Sterrenberg, Martin, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, Simons, Michelle, additional, Vossers, Marjolein, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, van Rijswijk, Cathelijn, additional, Messchendorp, Gert, additional, Nicolaij, Nynke, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, Maureen, additional, Verheesen, Sabrina, additional, Jeurrissen, D., additional, Bos, Erna, additional, Drabbe, Yvonne, additional, Sandiman, Michelle, additional, Aaldering, Nicoline, additional, Zweedijk, Berber, additional, Khalilzada, Mostafa, additional, Vervoort, Jocova, additional, Ponjee, Eva, additional, Romviel, Sharon, additional, Kanselaar, Karin, additional, Barning, Denn, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Tolhuisen, Manon L., additional, Alves, Heitor, additional, Weterings, Annick J., additional, Kirkels, Eleonora L.F., additional, Voogd, Eva J.H.F., additional, Schupp, Lieve M., additional, Collette, Sabine, additional, Groot, Adrien E.D., additional, LeCouffe, Natalie E., additional, Konduri, Praneeta R., additional, Prasetya, Haryadi, additional, Arrarte-Terreros, Nerea, additional, and Ramos, Lucas A., additional
- Published
- 2020
- Full Text
- View/download PDF
108. Automatic segmentation of cerebral infarcts in follow-up computed tomography images with convolutional neural networks
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Sales Barros, Renan, primary, Tolhuisen, Manon L, additional, Boers, Anna MM, additional, Jansen, Ivo, additional, Ponomareva, Elena, additional, Dippel, Diederik W J, additional, van der Lugt, Aad, additional, van Oostenbrugge, Robert J, additional, van Zwam, Wim H, additional, Berkhemer, Olvert A, additional, Goyal, Mayank, additional, Demchuk, Andrew M, additional, Menon, Bijoy K, additional, Mitchell, Peter, additional, Hill, Michael D, additional, Jovin, Tudor G, additional, Davalos, Antoni, additional, Campbell, Bruce C V, additional, Saver, Jeffrey L, additional, Roos, Yvo B W E M, additional, Muir, Keith W., additional, White, Phil, additional, Bracard, Serge, additional, Guillemin, Francis, additional, Olabarriaga, Silvia Delgado, additional, Majoie, Charles B L M, additional, and Marquering, Henk A, additional
- Published
- 2019
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109. Clinical and Imaging Markers Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke
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Kranendonk, Katinka R. van, Treumiet, Kilian M., Boers, Anna M.M., Berkhemer, Olvert A., Berg, Lucie A. van den, Chalos, Vicky, Dijk, E.J. van, Vries, J. de, Jenniskens, S.F.M., Berg, Rene van den, Koudstaal, Peter J., Kranendonk, Katinka R. van, Treumiet, Kilian M., Boers, Anna M.M., Berkhemer, Olvert A., Berg, Lucie A. van den, Chalos, Vicky, Dijk, E.J. van, Vries, J. de, Jenniskens, S.F.M., Berg, Rene van den, and Koudstaal, Peter J.
- Abstract
Item does not contain fulltext
- Published
- 2019
110. Hemorrhagic transformation is associated with poor functional outcome in patients with acute ischemic stroke due to a large vessel occlusion
- Author
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van Kranendonk, Katinka R., Treurniet, Kilian M., Boers, Anna M. M., Berkhemer, Olvert A., van den Berg, Lucie A., Chalos, Vicky, Lingsma, Hester F., van Zwam, Wim H., van der Lugt, Aad, van Oostenbrugge, Robert J., Dippel, Diederik W. J., Roos, Yvo B. W. E. M., Marquering, Henk A., Majoie, Charles B. L. M., MR CLEAN Investigators, van Kranendonk, Katinka R., Treurniet, Kilian M., Boers, Anna M. M., Berkhemer, Olvert A., van den Berg, Lucie A., Chalos, Vicky, Lingsma, Hester F., van Zwam, Wim H., van der Lugt, Aad, van Oostenbrugge, Robert J., Dippel, Diederik W. J., Roos, Yvo B. W. E. M., Marquering, Henk A., Majoie, Charles B. L. M., and MR CLEAN Investigators
- Abstract
Background and purpose Hemorrhagic transformation (HT) is a complication that may cause neurological deterioration in patients with acute ischemic stroke. Various radiological subtypes of HT can be distinguished. Their influence on functional outcome is currently unclear. The purpose of this study was to assess the associations between HT subtypes and functional outcome in acute ischemic stroke patients with proven large vessel occlusion included in the MR CLEAN trial (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic stroke in The Netherlands).Methods All patients with follow-up imaging were included. HT was classified on follow-up CT scans according to the European Cooperative Acute Stroke Study II classification. Functional outcome was assessed using the modified Rankin Scale (mRS) 90 days after stroke onset. Ordinal logistic regression analysis with adjustment for potential confounders was used to determine the association of HT subtypes with functional outcome.Results Of 478 patients, 222 had HT. Of these, 76 (16%) patients were classified as hemorrhagic infarction type 1, 71 (15%) as hemorrhagic infarction type 2, 36 (8%) as parenchymal hematoma type 1, and 39 (8%) as parenchymal hematoma type 2. Hemorrhagic infarction type 2 (adjusted common OR (acOR) 0.54, 95% CI: 0.32 to 0.89) and parenchymal hematoma type 2 (acOR 0.37, 95% CI 0.17 to 0.78) were significantly associated with a worse functional outcome. Hemorrhagic infarction type 1 and parenchymal hematoma type 1 were not significantly associated, although their point estimates pointed in the direction of worse outcome.Conclusion This study suggests that parenchymal hematoma type 2 is relevant for functional outcome after an acute ischemic stroke, and smaller HTs might also influence long term functional outcome.
- Published
- 2019
111. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
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Campbell, Bruce C. V., Majoie, Charles B. L. M., Albers, Gregory W., Menon, Bijoy K., Yassi, Nawaf, Sharma, Gagan, van Zwam, Wim H., van Oostenbrugge, Robert J., Demchuk, Andrew M., Guillemin, Francis, White, Philip, Davalos, Antoni, van der Lugt, Aad, Butcher, Kenneth S., Cherifi, Aboubaker, Marquering, Henk A., Cloud, Geoffrey, Macho Fernandez, Juan M., Madigan, Jeremy, Oppenheim, Catherine, Donnan, Geoffrey A., Roos, Yvo B. W. E. M., Shankar, Jai, Lingsma, Hester, Bonafe, Alain, Raoult, Helene, Hernandez-Perez, Maria, Bharatha, Aditya, Jahan, Reza, Jansen, Olav, Richard, Sebastien, Levy, Elad I., Berkhemer, Olvert A., Soudant, Marc, Aja, Lucia, Davis, Stephen M., Krings, Timo, Tisserand, Marie, San Roman, Luis, Tomasello, Alejandro, Beumer, Debbie, Brown, Scott, Liebeskind, David S., Bracard, Serge, Muir, Keith W., Dippel, Diederik W. J., Goyal, Mayank, Saver, Jeffrey L., Jovin, Tudor G., Hill, Michael D., HERMES Collaboration, Campbell, Bruce C. V., Majoie, Charles B. L. M., Albers, Gregory W., Menon, Bijoy K., Yassi, Nawaf, Sharma, Gagan, van Zwam, Wim H., van Oostenbrugge, Robert J., Demchuk, Andrew M., Guillemin, Francis, White, Philip, Davalos, Antoni, van der Lugt, Aad, Butcher, Kenneth S., Cherifi, Aboubaker, Marquering, Henk A., Cloud, Geoffrey, Macho Fernandez, Juan M., Madigan, Jeremy, Oppenheim, Catherine, Donnan, Geoffrey A., Roos, Yvo B. W. E. M., Shankar, Jai, Lingsma, Hester, Bonafe, Alain, Raoult, Helene, Hernandez-Perez, Maria, Bharatha, Aditya, Jahan, Reza, Jansen, Olav, Richard, Sebastien, Levy, Elad I., Berkhemer, Olvert A., Soudant, Marc, Aja, Lucia, Davis, Stephen M., Krings, Timo, Tisserand, Marie, San Roman, Luis, Tomasello, Alejandro, Beumer, Debbie, Brown, Scott, Liebeskind, David S., Bracard, Serge, Muir, Keith W., Dippel, Diederik W. J., Goyal, Mayank, Saver, Jeffrey L., Jovin, Tudor G., Hill, Michael D., and HERMES Collaboration
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Background CT perfusion (CTP) and diffusion or perfusion MRI might assist patient selection for endovascular thrombectomy. We aimed to establish whether imaging assessments of irreversibly injured ischaemic core and potentially salvageable penumbra volumes were associated with functional outcome and whether they interacted with the treatment effect of endovascular thrombectomy on functional outcome.Methods In this systematic review and meta-analysis, the HERMES collaboration pooled patient-level data from all randomised controlled trials that compared endovascular thrombectomy (predominantly using stent retrievers) with standard medical therapy in patients with anterior circulation ischaemic stroke, published in PubMed from Jan 1,2010, to May 31, 2017. The primary endpoint was functional outcome, assessed by the modified Rankin Scale (mRS) at 90 days after stroke. Ischaemic core was estimated, before treatment with either endovascular thrombectomy or standard medical therapy, by CTP as relative cerebral blood flow less than 30% of normal brain blood flow or by MRI as an apparent diffusion coefficient less than 620 mu m(2)/s. Critically hypoperfused tissue was estimated as the volume of tissue with a CTP time to maximum longer than 6 s. Mismatch volume (ie, the estimated penumbral volume) was calculated as critically hypoperfused tissue volume minus ischaemic core volume. The association of ischaemic core and penumbral volumes with 90-day mRS score was analysed with multivariable logistic regression (functional independence, defined as mRS score 0-2) and ordinal logistic regression (functional improvement by at least one mRS category) in all patients and in a subset of those with more than 50% endovascular reperfusion, adjusted for baseline prognostic variables. The meta-analysis was prospectively designed by the HERMES executive committee, but not registered.Findings We identified seven studies with 1764 patients, all of which were included in the m
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- 2019
112. Association of Time From Stroke Onset to Groin Puncture With Quality of Reperfusion After Mechanical Thrombectomy A Meta-analysis of Individual Patient Data From 7 Randomized Clinical Trials
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Bourcier, Romain, Goyal, Mayank, Liebeskind, David S., Muir, Keith W., Desal, Hubert, Siddiqui, Adnan H., Dippel, Diederik W. J., Majoie, Charles B., van Zwam, Wim H., Jovin, Tudor G., Levy, Elad I., Mitchell, Peter J., Berkhemer, Olvert A., Davis, Stephen M., Derraz, Linad, Donnan, Geoffrey A., Demchuk, Andrew M., van Oostenbrugge, Robert J., Kelly, Michael, Roos, Yvo B., Jahan, Reza, van der Lugt, Aad, Sprengers, Marieke, Velasco, Stephane, Nijeholt, Geert J. Lycklama A., Ben Hassen, Wagih, Burns, Paul, Brown, Scott, Chabert, Emmanuel, Krings, Timo, Chloe, Hana, Weimar, Christian, Campbell, Bruce C. V., Ford, Gary A., Ribo, Marc, White, Phil, Cloud, Geoffrey C., San Roman, Luis, Davalos, Antoni, Naggara, Olivier, Hill, Michael D., Bracard, Serge, HERMES Trialists Collaboration, Bourcier, Romain, Goyal, Mayank, Liebeskind, David S., Muir, Keith W., Desal, Hubert, Siddiqui, Adnan H., Dippel, Diederik W. J., Majoie, Charles B., van Zwam, Wim H., Jovin, Tudor G., Levy, Elad I., Mitchell, Peter J., Berkhemer, Olvert A., Davis, Stephen M., Derraz, Linad, Donnan, Geoffrey A., Demchuk, Andrew M., van Oostenbrugge, Robert J., Kelly, Michael, Roos, Yvo B., Jahan, Reza, van der Lugt, Aad, Sprengers, Marieke, Velasco, Stephane, Nijeholt, Geert J. Lycklama A., Ben Hassen, Wagih, Burns, Paul, Brown, Scott, Chabert, Emmanuel, Krings, Timo, Chloe, Hana, Weimar, Christian, Campbell, Bruce C. V., Ford, Gary A., Ribo, Marc, White, Phil, Cloud, Geoffrey C., San Roman, Luis, Davalos, Antoni, Naggara, Olivier, Hill, Michael D., Bracard, Serge, and HERMES Trialists Collaboration
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IMPORTANCE Reperfusion is a key factor for clinical outcome in patients with acute ischemic stroke (AIS) treated with endovascular thrombectomy (EVT) for large-vessel intracranial occlusion. However, data are scarce on the association between the time from onset and reperfusion results.OBJECTIVE To analyze the rate of reperfusion after EVT started at different intervals after symptom onset in patients with AIS.DESIGN, SETTING, AND PARTICIPANTS We conducted a meta-analysis of individual patient data from 7 randomized trials of the Highly Effective Reperfusion Using Multiple Endovascular Devices (HERMES) group. This is a multicenter cohort study of the intervention arm of randomized clinical trials included in the HERMES group. Patients with anterior circulation AIS who underwent EVT for M1/M2 or intracranial carotid artery occlusion were included. Each trial enrolled patients according to its specific inclusion and exclusion criteria. Data on patients eligible but not enrolled (eg, refusals or exclusions) were not available. All analyses were performed by the HERMES biostatistical core laboratory using the pooled database. Data were analyzed between December 2010 and April 2015.MAIN OUTCOMES AND MEASURES Successful reperfusion was defined as a modified thrombolysis in cerebral infarction score of 2b/3 at the end of the EVT procedure adjusted for age, occlusion location, pretreatment intravenous thrombolysis, and clot burden score and was analyzed in relation to different intervals (onset, emergency department arrival, imaging, and puncture) using mixed-methods logistic regression.RESULTS Among the 728 included patients, with a mean (SD) age of 65.4 (13.5) years and of whom 345 were female (47.4%), decreases in rates of successful reperfusion defined as a thrombolysis in cerebral infarction score of 2b/3 were observed with increasing time from admission or first imaging to groin puncture. The magnitude of effect was a 22% relative reduct
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- 2019
113. Comparison of three commonly used CT perfusion software packages in patients with acute ischemic stroke
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Koopman, Miou S., Berkhemer, Olvert A., Geuskens, Ralph R. E. G., Emmer, Bart J., van Walderveen, Marianne A. A., Jenniskens, Sjoerd F. M., van Zwam, Wim H., van Oostenbrugge, Robert J., van der Lugt, Aad, Dippel, Diederik W. J., Beenen, Ludo F., Roos, Yvo B. W. E. M., Marquering, Henk A., Majoie, Charles B. L. M., MR CLEAN Trial Investigators, Koopman, Miou S., Berkhemer, Olvert A., Geuskens, Ralph R. E. G., Emmer, Bart J., van Walderveen, Marianne A. A., Jenniskens, Sjoerd F. M., van Zwam, Wim H., van Oostenbrugge, Robert J., van der Lugt, Aad, Dippel, Diederik W. J., Beenen, Ludo F., Roos, Yvo B. W. E. M., Marquering, Henk A., Majoie, Charles B. L. M., and MR CLEAN Trial Investigators
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Background and purpose CT perfusion (CTP) might support decision making in patients with acute ischemic stroke by providing perfusion maps of ischemic tissue. Currently, the reliability of CTP is hampered by varying results between different post-processing software packages. The purpose of this study is to compare ischemic core volumes estimated by IntelliSpace Portal (ISP) and syngo.via with core volumes as estimated by RAPID. Methods Thirty-five CTP datasets from patients in the MR CLEAN trial were post-processed. Core volumes were estimated with ISP using default settings and with syngo.via using three different settings: default settings (method A); additional smoothing filter (method B); and adjusted settings (method C). The results were compared with RAPID. Agreement between methods was assessed using Bland-Altman analysis and intraclass correlation coefficient (ICC). Accuracy for detecting volumes up to 25 mL, 50 mL, and 70 mL was assessed. Final infarct volumes were determined on follow-up non-contrast CT. Results Median core volume was 50 mL with ISP, 41 mL with syngo.via method A, 20 mL with method B, 36 mL with method C, and 11 mL with RAPID. Agreement ranged from poor (ISP: ICC 0.41; method A: ICC 0.23) to good (method B: ICC 0.83; method C: ICC 0.85). The bias (1.8 mL) and limits of agreement (-27, 31 mL) were the smallest with syngo.via with additional smoothing (method B). Agreement for detecting core volumes
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- 2019
114. Follow-up infarct volume as a mediator of endovascular treatment effect on functional outcome in ischaemic stroke
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Compagne, Kars, Boers, AMM, Marquering, HA, Berkhemer, Olvert, Yoo, AJ, Beenen, LFM, van Oostenbrugge, RJ, Zwam, WH, Roos, Y, Majoie, CB, Es, Adriaan, van der Lugt, Aad, Dippel, Diederik, Lingsma, Hester, Compagne, Kars, Boers, AMM, Marquering, HA, Berkhemer, Olvert, Yoo, AJ, Beenen, LFM, van Oostenbrugge, RJ, Zwam, WH, Roos, Y, Majoie, CB, Es, Adriaan, van der Lugt, Aad, Dippel, Diederik, and Lingsma, Hester
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- 2019
115. Posttreatment Ischemic Lesion Evolution Is Associated With Reduced Favorable Functional Outcome in Patients With Stroke.
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Konduri, Praneeta, van Voorst, Henk, Bucker, Amber, van Kranendonk, Katinka, Boers, Anna, Treurniet, Kilian, Berkhemer, Olvert, Yoo, Albert J., van Zwam, Wim, van Oostenbrugge, Robert, van der Lugt, Aad, Dippel, Diederik, Roos, Yvo, Bot, Joost, Majoie, Charles, Marquering, Henk, and MR CLEAN Trial Investigators*
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- 2021
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116. Clinical Outcome After Endovascular Treatment in Patients With Active Cancer and Ischemic Stroke
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Verschoof, Merelijne A., Groot, Adrien E., de Bruijn, Sebastiaan F.T.M., Roozenbeek, Bob, van der Worp, H. Bart, Dippel, Diederik W.J., Emmer, Bart J., Roosendaal, Stefan D., Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., Coutinho, Jonathan M., Dippel, Diederik W.J., van der Lugt, Aad, Majoie, Charles B.L.M., Roos, Yvo B.W.E.M., van Oostenbrugge, Robert J., van Zwam, Wim H., Boiten, Jelis, Vos, Jan Albert, Jansen, Ivo G.H., Mulder, Maxim J.H.L., Goldhoorn, Robert-Jan B., Schonewille, Wouter J., Coutinho, Jonathan M., Wermer, Marieke J.H., van Walderveen, Marianne A.A., Staals, Julie, Hofmeijer, Jeannette, Martens, Jasper M., Lycklama à Nijeholt, Geert J., Roozenbeek, Bob, Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Bart van der Worp, H., Lo, Rob H., van Dijk, Ewoud J., Boogaarts, Hieronymus D., de Kort, Paul L.M., Peluso, Jo J.P., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Uyttenboogaart, Maarten, Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Yo, Lonneke S.F., den Hertog, Heleen M., Sturm, Emiel J.C., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., van den Berg, René, Yoo, Albert J., Beenen, Ludo F.M., Postma, Alida A., Roosendaal, Stefan D., van der Kallen, Bas F.W., van den Wijngaard, Ido R., van Es, Adriaan C.G.M., Bot, Joost, Doormaal, Pieter-Jan van, Flach, H. Zwenneke, Lingsma, Hester F., Ghannouti, Naziha el, Ghannouti, Naziha el, Puppels, Corina, Pellikaan, Wilma, Sprengers, Rita, Sprengers, Rita, de Meris, Joke, Vermeulen, Tamara, Geerlings, Annet, van Vemde, Gina, Simons, Tiny, van Rijswijk, Cathelijn, Messchendorp, Gert, Bongenaar, Hester, Bodde, Karin, Kleijn, Sandra, Lodico, Jasmijn, Droste, Hanneke, Wollaert, M., Jeurrissen, D., Bos, Erna, Drabbe, Yvonne, Zweedijk, Berber, Khalilzada, Mostafa, Venema, Esmee, Chalos, Vicky, Compagne, Kars C.J., Geuskens, Ralph R., van Straaten, Tim, Ergezen, Saliha, Harmsma, Roger R.M., Muijres, Daan, de Jong, Anouk, Hinsenveld, Wouter, Berkhemer, Olvert A., Boers, Anna M.M., Huguet, J., Groot, P.F.C., Mens, Marieke A., van Kranendonk, Katinka R., van Kranendonk, Katinka R., Kappelhof, Manon, Tolhuijsen, Manon L., and Alves, Heitor
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- 2022
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117. The Role of Edema in Subacute Lesion Progression After Treatment of Acute Ischemic Stroke.
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Konduri, Praneeta, van Kranendonk, Katinka, Boers, Anna, Treurniet, Kilian, Berkhemer, Olvert, Yoo, Albert J., van Zwam, Wim, Oostenbrugge, Robert van, van der Lugt, Aad, Dippel, Diederik, Roos, Yvo, Bot, Joost, Majoie, Charles, and Marquering, Henk
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STROKE ,ISCHEMIC stroke ,EDEMA ,STROKE patients ,FUNCTIONAL assessment - Abstract
Background: Ischemic lesions commonly continue to progress even days after treatment, and this lesion growth is associated with unfavorable functional outcome in acute ischemic stroke patients. The aim of this study is to elucidate the role of edema in subacute lesion progression and its influence on unfavorable functional outcome by quantifying net water uptake. Methods: We included all 187 patients from the MR CLEAN trial who had high quality follow-up non-contrast CT at 24 h and 1 week. Using a CT densitometry-based method to calculate the net water uptake, we differentiated total ischemic lesion volume (TILV) into edema volume (EV) and edema-corrected infarct volume (ecIV). We calculated these volumes at 24 h and 1 week after stroke and determined their progression in the subacute period. We assessed the effect of 24-h lesion characteristics on EV and ecIV progression. We evaluated the influence of edema and edema-corrected infarct progression on favorable functional outcome after 90 days (modified Rankin Scale: 0–2) after correcting for potential confounders. Lastly, we compared these volumes between subgroups of patients with and without successful recanalization using the Mann–Whitney U- test. Results: Median TILV increased from 37 (IQR: 18–81) ml to 68 (IQR: 30–130) ml between 24 h and 1 week after stroke, while the net water uptake increased from 22 (IQR: 16–26)% to 27 (IQR: 22–32)%. The TILV progression of 20 (8.8–40) ml was mostly caused by ecIV with a median increase of 12 (2.4–21) ml vs. 6.5 (2.7–15) ml of EV progression. Larger TILV, EV, and ecIV volumes at 24 h were all associated with more edema and lesion progression. Edema progression was associated with unfavorable functional outcome [aOR: 0.53 (0.28–0.94) per 10 ml; p -value: 0.05], while edema-corrected infarct progression showed a similar, non-significant association [aOR: 0.80 (0.62–0.99); p -value: 0.06]. Lastly, edema progression was larger in patients without successful recanalization, whereas ecIV progression was comparable between the subgroups. Conclusion: EV increases in evolving ischemic lesions in the period between 1 day and 1 week after acute ischemic stroke. This progression is larger in patients without successful recanalization and is associated with unfavorable functional outcome. However, the extent of edema cannot explain the total expansion of ischemic lesions since edema-corrected infarct progression is larger than the edema progression. [ABSTRACT FROM AUTHOR]
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- 2021
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118. Intracranial Carotid Artery Calcification and Effect of Endovascular Stroke Treatment
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Majoie, Charles B. L. M., Roos, Yvo B. W. E. M., Berkhemer, Olvert A., Study group members AMC, Marquering, Henk A., Radiology and Nuclear Medicine, ACS - Microcirculation, ANS - Neurovascular Disorders, Neurology, ACS - Atherosclerosis & ischemic syndromes, ACS - Amsterdam Cardiovascular Sciences, and Biomedical Engineering and Physics
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Background and Purpose- Previous studies suggest that intracranial carotid artery calcification (ICAC) volume might influence the clinical outcome of patients after endovascular treatment (EVT) for acute ischemic stroke. Importantly, ICAC can be subtyped into a medial or intimal pattern that may differentially influence the effect of EVT in patients with acute ischemic stroke. Methods- All 500 patients included in the MR CLEAN (Multicenter Randomized Clinical trial of Endovascular treatment for acute ischemic stroke in the Netherlands) were evaluated. Volume (mm3) and location pattern (tunica intima or tunica media) of ICAC could be determined on baseline noncontrast computed tomography in 344 patients. Functional outcome at 90 days was assessed with the modified Rankin Scale. Next, we investigated the association of ICAC volume and pattern with functional outcome using adjusted ordinal logistic regression models. Effect modification by EVT was assessed with an interaction term between treatment allocation and ICAC aspect. Results- We found evidence for treatment effect modification by ICAC pattern ( P interaction=0.04). Patients with predominantly medial calcification had better functional outcome with EVT than without this treatment (adjusted common odds ratio, 2.32; 95% CI, 1.23-4.39), but we observed no effect of EVT in patients with predominantly intimal calcifications (adjusted common odds ratio, 0.82; 95% CI, 0.40-1.68). We did not find an association of ICAC volume with functional outcome (adjusted common odds ratio per unit increase ICAC volume 1.01 (95% CI, 0.89-1.13). Moreover, we found no evidence for effect modification by ICAC volume ( P interaction=0.61). Conclusions- The benefit of EVT in acute ischemic stroke patients with a medial calcification pattern is larger than the benefit in patients with an intimal calcification pattern. Clinical Trial Registration- URL: http://www.trialregister.nl . Unique identifier: NTR1804. URL: http://www.isrctn.com . Unique identifier: ISRCTN10888758.
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- 2018
119. Combined Evaluation of Noncontrast CT ASPECTS and CT Angiography Collaterals Improves Detection of Large Infarcts in Proximal Artery Occlusive Stroke
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Mehrkhani, Farhad, Berkhemer, Olvert A., Majoie, Charles B. L. M., Mansouri, Mohammad, Karimi, Zahra, Lev, Michael H., Yoo, Albert J., Radiology and Nuclear Medicine, ACS - Amsterdam Cardiovascular Sciences, ACS - Microcirculation, ANS - Neurovascular Disorders, and ACS - Atherosclerosis & ischemic syndromes
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cardiovascular diseases - Abstract
BACKGROUND AND PURPOSE: Imaging may identify patients with very large infarcts who are unlikely to benefit from intra-arterial therapy. Although computed tomography (CT) is widely used, it suffers from poor sensitivity. We sought to evaluate whether combined evaluation of noncontrast CT (NCCT) and CT angiography (CTA) collaterals would improve the detection of large infarcts. METHODS: All patients with anterior circulation proximal artery occlusion and baseline CT, CTA, and magnetic resonance imaging (MRI) performed were identified. NCCT ASPECTS, CTA collateral score (CS), and diffusion-weighted imaging (DWI) lesion volume were determined. Receiver-operating characteristic analyses were performed to test the discrimination of NCCT ASPECTS 0-4, CTA malignant collaterals (CS = 0: absent collaterals in >50% of M2 territory), and the combination for DWI volume > 100 mL. RESULTS: Among 54 patients, mean age was 67 years; median NIHSS was 14. Occlusion locations were ICA terminus (18 [33%]), MCA M1 (20 [37%]), and M2 (16 [30%]). Median NCCT ASPECTS was 8; 8 (15%) had ASPECTS 0-4. Median CTA CS was 2; 9 (17%) were categorized as malignant. Median DWI lesion volume was 25 mL; 12 (22%) had lesions >100 mL. Individually, the CTA malignant collateral profile (98%) and NCCT ASPECTS 0-4 (100%) demonstrated high specificity for DWI lesion volume >100 mL, but had suboptimal sensitivity (both 67%). In the combined approach (CTA CS = 0 and/or NCCT ASPECTS ≤4), the sensitivity improved significantly to 92%, while maintaining high specificity (98%). CONCLUSIONS: Combined evaluation of NCCT ASPECTS and CTA collaterals identifies patients with infarcts >100 mL with high accuracy, and can improve patient selection using current CT techniques.
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- 2018
120. Comparison of three commonly used CT perfusion software packages in patients with acute ischemic stroke
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Koopman, Miou S, primary, Berkhemer, Olvert A, additional, Geuskens, Ralph R E G, additional, Emmer, Bart J, additional, van Walderveen, Marianne A A, additional, Jenniskens, Sjoerd F M, additional, van Zwam, Wim H, additional, van Oostenbrugge, Robert J, additional, van der Lugt, Aad, additional, Dippel, Diederik W J, additional, Beenen, Ludo F, additional, Roos, Yvo B W E M, additional, Marquering, Henk A, additional, and Majoie, Charles B L M, additional
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- 2019
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121. Endovascular Treatment With or Without Prior Intravenous Alteplase for Acute Ischemic Stroke
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Chalos, Vicky, primary, LeCouffe, Natalie E., additional, Uyttenboogaart, Maarten, additional, Lingsma, Hester F., additional, Mulder, Maxim J. H. L., additional, Venema, Esmee, additional, Treurniet, Kilian M., additional, Eshghi, Omid, additional, van der Worp, H. Bart, additional, van der Lugt, Aad, additional, Roos, Yvo B. W. E. M., additional, Majoie, Charles B. L. M., additional, Dippel, Diederik W. J., additional, Roozenbeek, Bob, additional, Coutinho, Jonathan M., additional, van Oostenbrugge, Robert J., additional, van Zwam, Wim H., additional, Boiten, Jelis, additional, Vos, Jan Albert, additional, Jansen, Ivo G. H., additional, Goldhoorn, Robert‐Jan B., additional, Schonewille, Wouter J., additional, Wermer, Marieke J. H., additional, van Walderveen, Marianne A. A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, Lycklama à Nijeholt, Geert J., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Kort, Paul L. M., additional, Peluso, Jo J. P., additional, van den Berg, Jan S. P., additional, van Hasselt, Boudewijn A. A. M., additional, Aerden, Leo A. M., additional, Dallinga, René J., additional, Schreuder, Tobien H. C. M. L., additional, Heijboer, Roel J. J., additional, Keizer, Koos, additional, Yo, Lonneke S. F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J. C., additional, Sprengers, Marieke E. S., additional, Jenniskens, Sjoerd F. M., additional, van den Berg, René, additional, Yoo, Albert J., additional, Beenen, Ludo F. M., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F. W., additional, van den Wijngaard, Ido R., additional, van Es, Adriaan C. G. M., additional, Bot, Joseph C. J., additional, van Doormaal, Pieter‐Jan, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, van Rijswijk, Cathelijn, additional, Messchendorp, Gert, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, M., additional, Jeurrissen, D., additional, Bos, Ernas, additional, Drabbe, Yvonne, additional, Zweedijk, Berber, additional, Khalilzada, Mostafa, additional, Compagne, Kars C. J., additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R. M., additional, de Jong, Anouk, additional, Hinsenveld, Wouter, additional, Berkhemer, Olvert A., additional, Boers, Anna M. M., additional, Groot, P. F. C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Kappelhof, Manon, additional, Tolhuijsen, Manon L., additional, and Alves, Heitor, additional
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- 2019
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122. Abstract WP34: ASPIRE: Aspiration Thrombectomy as the Primary Modality in Endovascular Stroke Treatment: Pooled Analysis of the 3D Stent-Retriever, ASTER, THERAPY, COMPASS and MR CLEAN Trials
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Nogueira, Raul G, primary, van de Graaf, Rob A, additional, Mocco, J, additional, Siddiqui, Adnan, additional, Lapergue, Bertrand, additional, Piotin, Michel, additional, Turk, Aquilla, additional, Berkhemer, Olvert A, additional, Lingsma, Hester, additional, Majoie, Charles B, additional, Samuels, Noor, additional, Yoo, Albert, additional, Frei, Donald, additional, Zaidat, Osama O, additional, Khatri, Pooja, additional, and Dippel, Diederik W, additional
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- 2019
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123. Endovascular Treatment
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Compagne, Kars C.J., primary, van der Sluijs, Pieter M., additional, van den Wijngaard, Ido R., additional, Roozenbeek, Bob, additional, Mulder, Maxim J.H.L., additional, van Zwam, Wim H., additional, Emmer, Bart J., additional, Majoie, Charles B.L.M., additional, Yoo, Albert J., additional, Lycklama à Nijeholt, Geert J., additional, Lingsma, Hester F., additional, Dippel, Diederik W.J., additional, van der Lugt, Aad, additional, van Es, Adriaan C.G.M., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Boiten, Jelis, additional, Vos, Jan Albert, additional, Jansen, Ivo G.H., additional, Goldhoorn, Robert-Jan B., additional, Schonewille, Wouter J., additional, Coutinho, Jonathan M., additional, Wermer, Marieke J.H., additional, van Walderveen, Marianne A.A., additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, Martens, Jasper M., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, van der Worp, H. Bart, additional, Lo, Rob H., additional, van Dijk, Ewoud J., additional, Boogaarts, Hieronymus D., additional, de Kort, Paul L.M., additional, Peluso, Jo J.P., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Uyttenboogaart, Maarten, additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Yo, Lonneke S.F., additional, den Hertog, Heleen M., additional, Sturm, Emiel J.C., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, van den Berg, René, additional, Beenen, Ludo F.M., additional, Postma, Alida A., additional, Roosendaal, Stefan D., additional, van der Kallen, Bas F.W., additional, Bot, Joost, additional, van Doormaal, Pieter-Jan, additional, Flach, H. Zwenneke, additional, el Ghannouti, Naziha, additional, Sterrenberg, Martin, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Sprengers, Rita, additional, Elfrink, Marjan, additional, de Meris, Joke, additional, Vermeulen, Tamara, additional, Geerlings, Annet, additional, van Vemde, Gina, additional, Simons, Tiny, additional, van Rijswijk, Cathelijn, additional, Messchendorp, Gert, additional, Bongenaar, Hester, additional, Bodde, Karin, additional, Kleijn, Sandra, additional, Lodico, Jasmijn, additional, Droste, Hanneke, additional, Wollaert, M., additional, Jeurrissen, D., additional, Bos, Ernas, additional, Drabbe, Yvonne, additional, Zweedijk, Berber, additional, Khalilzada, Mostafa, additional, Venema, Esmee, additional, Chalos, Vicky, additional, Geuskens, Ralph R., additional, van Straaten, Tim, additional, Ergezen, Saliha, additional, Harmsma, Roger R.M., additional, Muijres, Daan, additional, de Jong, Anouk, additional, Hinseveld, Wouter, additional, Berkhemer, Olvert A., additional, Boers, Anna M.M., additional, Huguet, J., additional, Groot, P.F.C., additional, Mens, Marieke A., additional, van Kranendonk, Katinka R., additional, Treurniet, Kilian M., additional, Kappelhof, Manon, additional, Tolhuijsen, Manon L., additional, and Alves, Heitor, additional
- Published
- 2019
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124. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
- Author
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Campbell, Bruce C V, primary, Majoie, Charles B L M, additional, Albers, Gregory W, additional, Menon, Bijoy K, additional, Yassi, Nawaf, additional, Sharma, Gagan, additional, van Zwam, Wim H, additional, van Oostenbrugge, Robert J, additional, Demchuk, Andrew M, additional, Guillemin, Francis, additional, White, Philip, additional, Dávalos, Antoni, additional, van der Lugt, Aad, additional, Butcher, Kenneth S, additional, Cherifi, Aboubaker, additional, Marquering, Henk A, additional, Cloud, Geoffrey, additional, Macho Fernández, Juan M, additional, Madigan, Jeremy, additional, Oppenheim, Catherine, additional, Donnan, Geoffrey A, additional, Roos, Yvo B W E M, additional, Shankar, Jai, additional, Lingsma, Hester, additional, Bonafé, Alain, additional, Raoult, Hélène, additional, Hernández-Pérez, María, additional, Bharatha, Aditya, additional, Jahan, Reza, additional, Jansen, Olav, additional, Richard, Sébastien, additional, Levy, Elad I, additional, Berkhemer, Olvert A, additional, Soudant, Marc, additional, Aja, Lucia, additional, Davis, Stephen M, additional, Krings, Timo, additional, Tisserand, Marie, additional, San Román, Luis, additional, Tomasello, Alejandro, additional, Beumer, Debbie, additional, Brown, Scott, additional, Liebeskind, David S, additional, Bracard, Serge, additional, Muir, Keith W, additional, Dippel, Diederik W J, additional, Goyal, Mayank, additional, Saver, Jeffrey L, additional, Jovin, Tudor G, additional, Hill, Michael D, additional, Mitchell, Peter J, additional, Fransen, Puck SS, additional, van den Berg, Lucie A, additional, Lingsma, Hester F, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, additional, Williams, J, additional, Wiegner, R, additional, Casaubon, LK, additional, Jaigobin, C, additional, del Campo, JM, additional, Elamin, E, additional, Schaafsma, JD, additional, Agid, R, additional, Farb, R, additional, ter Brugge, K, additional, Sapkoda, BL, additional, Baxter, BW, additional, Barton, K, additional, Knox, A, additional, Porter, A, additional, Sirelkhatim, A, additional, Devlin, T, additional, Dellinger, C, additional, Pitiyanuvath, N, additional, Patterson, J, additional, Nichols, J, additional, Quarfordt, S, additional, Calvert, J, additional, Hawk, H, additional, Fanale, C, additional, Bitner, A, additional, Novak, A, additional, Huddle, D, additional, Bellon, R, additional, Loy, D, additional, Wagner, J, additional, Chang, I, additional, Lampe, E, additional, Spencer, B, additional, Pratt, R, additional, Bartt, R, additional, Shine, S, additional, Dooley, G, additional, Nguyen, T, additional, Whaley, M, additional, McCarthy, K, additional, Teitelbaum, J, additional, Poon, W, additional, Campbell, N, additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez- Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, P, additional, Golob, D, additional, Gladstone, D, additional, Boyle, K, additional, Boulos, M, additional, Hopyan, J, additional, Yang, V, additional, Da Costa, L, additional, Holmstedt, CA, additional, Turk, AS, additional, Navarro, R, additional, Jauch, E, additional, Ozark, S, additional, Turner, R, additional, Phillips, S, additional, Shankar, J, additional, Jarrett, J, additional, Gubitz, G, additional, Maloney, W, additional, Vandorpe, R, additional, Schmidt, M, additional, Heidenreich, J, additional, Hunter, G, additional, Kelly, M, additional, Whelan, R, additional, Peeling, L, additional, Burns, PA, additional, Hunter, A, additional, Wiggam, I, additional, Kerr, E, additional, Watt, M, additional, Fulton, A, additional, Gordon, P, additional, Rennie, I, additional, Flynn, P, additional, Smyth, G, additional, O'Leary, S, additional, Gentile, N, additional, Linares, G, additional, McNelis, P, additional, Erkmen, K, additional, Katz, P, additional, Azizi, A, additional, Weaver, M, additional, Jungreis, C, additional, Faro, S, additional, Shah, P, additional, Reimer, H, additional, Kalugdan, V, additional, Saposnik, G, additional, Bharatha, A, additional, Li, Y, additional, Kostyrko, P, additional, Marotta, T, additional, Montanera, W, additional, Sarma, D, additional, Selchen, D, additional, Spears, J, additional, Heo, JH, additional, Jeong, K, additional, Kim, DJ, additional, Kim, BM, additional, Kim, YD, additional, Song, D, additional, Lee, K-J, additional, Yoo, J, additional, Bang, OY, additional, Rho, S, additional, Lee, J, additional, Jeon, P, additional, Kim, KH, additional, Cha, J, additional, Kim, SJ, additional, Ryoo, S, additional, Lee, MJ, additional, Sohn, S-I, additional, Kim, C-H, additional, Ryu, H-G, additional, Hong, J-H, additional, Chang, H-W, additional, Lee, C-Y, additional, Rha, J, additional, Campbell, Bruce CV, additional, Churilov, Leonid, additional, Yan, Bernard, additional, Dowling, Richard, additional, Oxley, Thomas J, additional, Wu, Teddy Y, additional, Silver, Gabriel, additional, McDonald, Amy, additional, McCoy, Rachael, additional, Kleinig, Timothy J, additional, Scroop, Rebecca, additional, Dewey, Helen M, additional, Simpson, Marion, additional, Brooks, Mark, additional, Coulton, Bronwyn, additional, Krause, Martin, additional, Harrington, Timothy J, additional, Steinfort, Brendan, additional, Faulder, Kenneth, additional, Priglinger, Miriam, additional, Day, Susan, additional, Phan, Thanh, additional, Chong, Winston, additional, Holt, Michael, additional, Chandra, Ronil V, additional, Ma, Henry, additional, Young, Dennis, additional, Wong, Kitty, additional, Wijeratne, Tissa, additional, Tu, Hans, additional, Mackay, Elizabeth, additional, Celestino, Sherisse, additional, Bladin, Christopher F, additional, Loh, Poh Sien, additional, Gilligan, Amanda, additional, Ross, Zofia, additional, Coote, Skye, additional, Frost, Tanya, additional, Parsons, Mark W, additional, Miteff, Ferdinand, additional, Levi, Christopher R, additional, Ang, Timothy, additional, Spratt, Neil, additional, Kaauwai, Lara, additional, Badve, Monica, additional, Rice, Henry, additional, de Villiers, Laetitia, additional, Barber, P. Alan, additional, McGuinness, Ben, additional, Hope, Ayton, additional, Moriarty, Maurice, additional, Bennett, Patricia, additional, Wong, Andrew, additional, Coulthard, Alan, additional, Lee, Andrew, additional, Jannes, Jim, additional, Field, Deborah, additional, Salinas, Simon, additional, Cowley, Elise, additional, Snow, Barry, additional, Kolbe, John, additional, Stark, Richard, additional, King, John, additional, Macdonnell, Richard, additional, Attia, John, additional, D'Este, Cate, additional, Diener, Hans-Christoph, additional, Levy, Elad I., additional, Mendes Pereira, Vitor, additional, Albers, Gregory W., additional, Cognard, Christophe, additional, Cohen, David J., additional, Hacke, Werner, additional, Jovin, Tudor G., additional, Mattle, Heinrich P., additional, Nogueira, Raul G., additional, Siddiqui, Adnan H., additional, Yavagal, Dileep R., additional, von Kummer, Rüdiger, additional, Smith, Wade, additional, Turjman, Francis, additional, Hamilton, Scott, additional, Chiacchierini, Richard, additional, Amar, Arun, additional, Sanossian, Nerses, additional, Loh, Yince, additional, Baxter, B, additional, Reddy, VK, additional, Horev, A, additional, Star, M, additional, Siddiqui, A, additional, Hopkins, LN, additional, Snyder, K, additional, Sawyer, R, additional, Hall, S, additional, Costalat, V, additional, Riquelme, C, additional, Machi, P, additional, Omer, E, additional, Arquizan, C, additional, Mourand, I, additional, Charif, M, additional, Ayrignac, X, additional, Menjot de Champfleur, N, additional, Leboucq, N, additional, Gascou, G, additional, Moynier, M, additional, du Mesnil de Rochemont, R, additional, Singer, O, additional, Berkefeld, J, additional, Foerch, C, additional, Lorenz, M, additional, Pfeilschifer, W, additional, Hattingen, E, additional, Wagner, M, additional, You, SJ, additional, Lescher, S, additional, Braun, H, additional, Dehkharghani, S, additional, Belagaje, SR, additional, Anderson, A, additional, Lima, A, additional, Obideen, M, additional, Haussen, D, additional, Dharia, R, additional, Frankel, M, additional, Patel, V, additional, Owada, K, additional, Saad, A, additional, Amerson, L, additional, Horn, C, additional, Doppelheuer, S, additional, Schindler, K, additional, Lopes, DK, additional, Chen, M, additional, Moftakhar, R, additional, Anton, C, additional, Smreczak, M, additional, Carpenter, JS, additional, Boo, S, additional, Rai, A, additional, Roberts, T, additional, Tarabishy, A, additional, Gutmann, L, additional, Brooks, C, additional, Brick, J, additional, Domico, J, additional, Reimann, G, additional, Hinrichs, K, additional, Becker, M, additional, Heiss, E, additional, Selle, C, additional, Witteler, A, additional, Al-Boutros, S, additional, Danch, M-J, additional, Ranft, A, additional, Rohde, S, additional, Burg, K, additional, Weimar, C, additional, Zegarac, V, additional, Hartmann, C, additional, Schlamann, M, additional, Göricke, S, additional, Ringlestein, A, additional, Wanke, I, additional, Mönninghoff, C, additional, Dietzold, M, additional, Budzik, R, additional, Davis, T, additional, Eubank, G, additional, Hicks, WJ, additional, Pema, P, additional, Vora, N, additional, Mejilla, J, additional, Taylor, M, additional, Clark, W, additional, Rontal, A, additional, Fields, J, additional, Peterson, B, additional, Nesbit, G, additional, Lutsep, H, additional, Bozorgchami, H, additional, Priest, R, additional, Ologuntoye, O, additional, Barnwell, S, additional, Dogan, A, additional, Herrick, K, additional, Takahasi, C, additional, Beadell, N, additional, Brown, B, additional, Jamieson, S, additional, Hussain, MS, additional, Russman, A, additional, Hui, F, additional, Wisco, D, additional, Uchino, K, additional, Khawaja, Z, additional, Katzan, I, additional, Toth, G, additional, Cheng-Ching, E, additional, Bain, M, additional, Man, S, additional, Farrag, A, additional, George, P, additional, John, S, additional, Shankar, L, additional, Drofa, A, additional, Dahlgren, R, additional, Bauer, A, additional, Itreat, A, additional, Taqui, A, additional, Cerejo, R, additional, Richmond, A, additional, Ringleb, P, additional, Bendszus, M, additional, Möhlenbruch, M, additional, Reiff, T, additional, Amiri, H, additional, Purrucker, J, additional, Herweh, C, additional, Pham, M, additional, Menn, O, additional, Ludwig, I, additional, Acosta, I, additional, Villar, C, additional, Morgan, W, additional, Sombutmai, C, additional, Hellinger, F, additional, Allen, E, additional, Bellew, M, additional, Gandhi, R, additional, Bonwit, E, additional, Aly, J, additional, Ecker, RD, additional, Seder, D, additional, Morris, J, additional, Skaletsky, M, additional, Belden, J, additional, Baker, C, additional, Connolly, LS, additional, Papanagiotou, P, additional, Roth, C, additional, Kastrup, A, additional, Politi, M, additional, Brunner, F, additional, Alexandrou, M, additional, Merdivan, H, additional, Ramsey, C, additional, Given II, C, additional, Renfrow, S, additional, Deshmukh, V, additional, Sasadeusz, K, additional, Vincent, F, additional, Thiesing, JT, additional, Putnam, J, additional, Bhatt, A, additional, Kansara, A, additional, Caceves, D, additional, Lowenkopf, T, additional, Yanase, L, additional, Zurasky, J, additional, Dancer, S, additional, Freeman, B, additional, Scheibe-Mirek, T, additional, Robison, J, additional, Roll, J, additional, Clark, D, additional, Rodriguez, M, additional, Fitzsimmons, B-FM, additional, Zaidat, O, additional, Lynch, JR, additional, Lazzaro, M, additional, Larson, T, additional, Padmore, L, additional, Das, E, additional, Farrow-Schmidt, A, additional, Hassan, A, additional, Tekle, W, additional, Cate, C, additional, Jansen, O, additional, Cnyrim, C, additional, Wodarg, F, additional, Wiese, C, additional, Binder, A, additional, Riedel, C, additional, Rohr, A, additional, Lang, N, additional, Laufs, H, additional, Krieter, S, additional, Remonda, L, additional, Diepers, M, additional, Añon, J, additional, Nedeltchev, K, additional, Kahles, T, additional, Biethahn, S, additional, Lindner, M, additional, Chang, V, additional, Gächter, C, additional, Esperon, C, additional, Guglielmetti, M, additional, Arenillas Lara, JF, additional, Martínez Galdámez, M, additional, Calleja Sanz, AI, additional, Cortijo Garcia, E, additional, Garcia Bermejo, P, additional, Perez, S, additional, Mulero Carrillo, P, additional, Crespo Vallejo, E, additional, Ruiz Piñero, M, additional, Lopez Mesonero, L, additional, Reyes Muñoz, FJ, additional, Brekenfeld, C, additional, Buhk, J-H, additional, Krützelmann, A, additional, Thomalla, G, additional, Cheng, B, additional, Beck, C, additional, Hoppe, J, additional, Goebell, E, additional, Holst, B, additional, Grzyska, U, additional, Wortmann, G, additional, Starkman, S, additional, Duckwiler, G, additional, Jahan, R, additional, Rao, N, additional, Sheth, S, additional, Ng, K, additional, Noorian, A, additional, Szeder, V, additional, Nour, M, additional, McManus, M, additional, Huang, J, additional, Tarpley, J, additional, Tateshima, S, additional, Gonzalez, N, additional, Ali, L, additional, Liebeskind, D, additional, Hinman, J, additional, Calderon-Arnulphi, M, additional, Liang, C, additional, Guzy, J, additional, Koch, S, additional, DeSousa, K, additional, Gordon-Perue, G, additional, Elhammady, M, additional, Peterson, E, additional, Pandey, V, additional, Dharmadhikari, S, additional, Khandelwal, P, additional, Malik, A, additional, Pafford, R, additional, Gonzalez, P, additional, Ramdas, K, additional, Andersen, G, additional, Damgaard, D, additional, Von Weitzel-Mudersbach, P, additional, Simonsen, C, additional, Ruiz de Morales Ayudarte, N, additional, Poulsen, M, additional, Sørensen, L, additional, Karabegovich, S, additional, Hjørringgaard, M, additional, Hjort, N, additional, Harbo, T, additional, Sørensen, K, additional, Deshaies, E, additional, Padalino, D, additional, Swarnkar, A, additional, Latorre, JG, additional, Elnour, E, additional, El-Zammar, Z, additional, Villwock, M, additional, Farid, H, additional, Balgude, A, additional, Cross, L, additional, Hansen, K, additional, Holtmannspötter, M, additional, Kondziella, D, additional, Hoejgaard, J, additional, Taudorf, S, additional, Soendergaard, H, additional, Wagner, A, additional, Cronquist, M, additional, Stavngaard, T, additional, Cortsen, M, additional, Krarup, LH, additional, Hyldal, T, additional, Haring, H-P, additional, Guggenberger, S, additional, Hamberger, M, additional, Trenkler, J, additional, Sonnberger, M, additional, Nussbaumer, K, additional, Dominger, C, additional, Bach, E, additional, Jagadeesan, BD, additional, Taylor, R, additional, Kim, J, additional, Shea, K, additional, Tummala, R, additional, Zacharatos, H, additional, Sandhu, D, additional, Ezzeddine, M, additional, Grande, A, additional, Hildebrandt, D, additional, Miller, K, additional, Scherber, J, additional, Hendrickson, A, additional, Jumaa, M, additional, Zaidi, S, additional, Hendrickson, T, additional, Snyder, V, additional, Killer-Oberpfalzer, M, additional, Mutzenbach, J, additional, Weymayr, F, additional, Broussalis, E, additional, Stadler, K, additional, Jedlitschka, A, additional, Malek, A, additional, Mueller-Kronast, N, additional, Beck, P, additional, Martin, C, additional, Summers, D, additional, Day, J, additional, Bettinger, I, additional, Holloway, W, additional, Olds, K, additional, Arkin, S, additional, Akhtar, N, additional, Boutwell, C, additional, Crandall, S, additional, Schwartzman, M, additional, Weinstein, C, additional, Brion, B, additional, Prothmann, S, additional, Kleine, J, additional, Kreiser, K, additional, Boeckh-Behrens, T, additional, Poppert, H, additional, Wunderlich, S, additional, Koch, ML, additional, Biberacher, V, additional, Huberle, A, additional, Gora-Stahlberg, G, additional, Knier, B, additional, Meindl, T, additional, Utpadel-Fischler, D, additional, Zech, M, additional, Kowarik, M, additional, Seifert, C, additional, Schwaiger, B, additional, Puri, A, additional, Hou, S, additional, Wakhloo, A, additional, Moonis, M, additional, Henninger, N, additional, Goddeau, R, additional, Massari, F, additional, Minaeian, A, additional, Lozano, JD, additional, Ramzan, M, additional, Stout, C, additional, Patel, A, additional, Tunguturi, A, additional, Onteddu, S, additional, Carandang, R, additional, Howk, M, additional, Ribó, M, additional, Sanjuan, E, additional, Rubiera, M, additional, Pagola, J, additional, Flores, A, additional, Muchada, M, additional, Meler, P, additional, Huerga, E, additional, Gelabert, S, additional, Coscojuela, P, additional, Tomasello, A, additional, Rodriguez, D, additional, Santamarina, E, additional, Maisterra, O, additional, Boned, S, additional, Seró, L, additional, Rovira, A, additional, Molina, CA, additional, Millán, M, additional, Muñoz, L, additional, Pérez de la Ossa, N, additional, Gomis, M, additional, Dorado, L, additional, López-Cancio, E, additional, Palomeras, E, additional, Munuera, J, additional, García Bermejo, P, additional, Remollo, S, additional, Castaño, C, additional, García-Sort, R, additional, Cuadras, P, additional, Puyalto, P, additional, Hernández-Pérez, M, additional, Jiménez, M, additional, Martínez-Piñeiro, A, additional, Lucente, G, additional, Dávalos, A, additional, Chamorro, A, additional, Urra, X, additional, Obach, V, additional, Cervera, A, additional, Amaro, S, additional, Llull, L, additional, Codas, J, additional, Balasa, M, additional, Navarro, J, additional, Ariño, H, additional, Aceituno, A, additional, Rudilosso, S, additional, Renu, A, additional, Macho, JM, additional, San Roman, L, additional, Blasco, J, additional, López, A, additional, Macías, N, additional, Cardona, P, additional, Quesada, H, additional, Rubio, F, additional, Cano, L, additional, Lara, B, additional, de Miquel, MA, additional, Aja, L, additional, Serena, J, additional, Cobo, E, additional, Lees, Kennedy R, additional, Arenillas, J, additional, Roberts, R, additional, Al-Ajlan, F, additional, Zimmel, L, additional, Patel, S, additional, Martí-Fàbregas, J, additional, Salvat-Plana, M, additional, Bracard, S, additional, Ducrocq, Xavier, additional, Anxionnat, René, additional, Baillot, Pierre-Alexandre, additional, Barbier, Charlotte, additional, Derelle, Anne-Laure, additional, Lacour, Jean-Christophe, additional, Samson, Yves, additional, Sourour, Nader, additional, Baronnet-Chauvet, Flore, additional, Clarencon, Frédéric, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Di Maria, Federico, additional, Le Bouc, Raphael, additional, Leger, Anne, additional, Mutlu, Gurkan, additional, Rosso, Charlotte, additional, Szatmary, Zoltan, additional, Yger, Marion, additional, Zavanone, Chiara, additional, Bakchine, Serge, additional, Pierot, Laurent, additional, Caucheteux, Nathalie, additional, Estrade, Laurent, additional, Kadziolka, Krzysztof, additional, Leautaud, Alexandre, additional, Renkes, Céline, additional, Serre, Isabelle, additional, Desal, Hubert, additional, Guillon, Benoît, additional, Boutoleau-Bretonniere, Claire, additional, Daumas-Duport, Benjamin, additional, De Gaalon, Solène, additional, Derkinderen, Pascal, additional, Evain, Sarah, additional, Herisson, Fanny, additional, Laplaud, David-Axel, additional, Lebouvier, Thibaud, additional, Lintia-Gaultier, Alina, additional, Pouclet-Courtemanche, Hélène, additional, Rouaud, Tiphaine, additional, Rouaud Jaffrenou, Violaine, additional, Schunck, Aurélia, additional, Sevin-Allouet, Mathieu, additional, Toulgoat, Frederique, additional, Wiertlewski, Sandrine, additional, Gauvrit, Jean-Yves, additional, Ronziere, Thomas, additional, Cahagne, Vincent, additional, Ferre, Jean-Christophe, additional, Pinel, Jean-François, additional, Mas, Jean-Louis, additional, Meder, Jean-François, additional, Al Najjar-Carpentier, Amen-Adam, additional, Birchenall, Julia, additional, Bodiguel, Eric, additional, Calvet, David, additional, Domigo, Valérie, additional, Godon-Hardy, Sylvie, additional, Guiraud, Vincent, additional, Lamy, Catherine, additional, Majhadi, Loubna, additional, Morin, Ludovic, additional, Naggara, Olivier, additional, Trystram, Denis, additional, Turc, Guillaume, additional, Berge, Jérôme, additional, Sibon, Igor, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Rouanet, François, additional, Debruxelles, Sabrina, additional, Kazadi, Annabelle, additional, Renou, Pauline, additional, Fleury, Olivier, additional, Pasco-Papon, Anne, additional, Dubas, Frédéric, additional, Caroff, Jildaz, additional, Godard Ducceschi, Sophie, additional, Hamon, Marie-Aurélie, additional, Lecluse, Alderic, additional, Marc, Guillaume, additional, Giroud, Maurice, additional, Ricolfi, Frédéric, additional, Bejot, Yannick, additional, Chavent, Adrien, additional, Gentil, Arnaud, additional, Kazemi, Apolline, additional, Osseby, Guy-Victor, additional, Voguet, Charlotte, additional, Mahagne, Marie-Hélène, additional, Sedat, Jacques, additional, Chau, Yves, additional, Suissa, Laurent, additional, Lachaud, Sylvain, additional, Houdart, Emmanuel, additional, Stapf, Christian, additional, Buffon Porcher, Frédérique, additional, Chabriat, Hugues, additional, Guedin, Pierre, additional, Herve, Dominique, additional, Jouvent, Eric, additional, Mawet, Jérôme, additional, Saint-Maurice, Jean-Pierre, additional, Schneble, Hans-Martin, additional, Nighoghossian, Norbert, additional, Berhoune, Nadia-Nawel, additional, Bouhour, Françoise, additional, Cho, Tae-Hee, additional, Derex, Laurent, additional, Felix, Sandra, additional, Gervais-Bernard, Hélène, additional, Gory, Benjamin, additional, Manera, Luis, additional, Mechtouff, Laura, additional, Ritzenthaler, Thomas, additional, Riva, Roberto, additional, Salaris Silvio, Fabrizio, additional, Tilikete, Caroline, additional, Blanc, Raphael, additional, Obadia, Michaël, additional, Bartolini, Mario Bruno, additional, Gueguen, Antoine, additional, Piotin, Michel, additional, Pistocchi, Silvia, additional, Redjem, Hocine, additional, Drouineau, Jacques, additional, Neau, Jean-Philippe, additional, Godeneche, Gaelle, additional, Lamy, Matthias, additional, Marsac, Emilia, additional, Velasco, Stephane, additional, Clavelou, Pierre, additional, Chabert, Emmanuel, additional, Bourgois, Nathalie, additional, Cornut-Chauvinc, Catherine, additional, Ferrier, Anna, additional, Gabrillargues, Jean, additional, Jean, Betty, additional, Marques, Anna-Raquel, additional, Vitello, Nicolas, additional, Detante, Olivier, additional, Barbieux, Marianne, additional, Boubagra, Kamel, additional, Favre Wiki, Isabelle, additional, Garambois, Katia, additional, Tahon, Florence, additional, Ashok, Vasdev, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Lapergue, Bertrand, additional, Bourdain, Frédéric, additional, Evrard, Serge, additional, Graveleau, Philippe, additional, Decroix, Jean Pierre, additional, Wang, Adrien, additional, Sellal, François, additional, Ahle, Guido, additional, Carelli, Gabriela, additional, Dugay, Marie-Hélène, additional, Gaultier, Claude, additional, Lebedinsky, Ariel Pablo, additional, Lita, Lavinia, additional, Musacchio, Raul Mariano, additional, Renglewicz-Destuynder, Catherine, additional, Tournade, Alain, additional, Vuillemet, Françis, additional, Montoro, Francisco Macian, additional, Mounayer, Charbel, additional, Faugeras, Frederic, additional, Gimenez, Laetitia, additional, Labach, Catherine, additional, Lautrette, Géraldine, additional, Denier, Christian, additional, Saliou, Guillaume, additional, Chassin, Olivier, additional, Dussaule, Claire, additional, Melki, Elsa, additional, Ozanne, Augustin, additional, Puccinelli, Francesco, additional, Sachet, Marina, additional, Sarov, Mariana, additional, Bonneville, Jean-François, additional, Moulin, Thierry, additional, Biondi, Alessandra, additional, De Bustos Medeiros, Elisabeth, additional, Vuillier, Fabrice, additional, Courtheoux, Patrick, additional, Viader, Fausto, additional, Apoil-Brissard, Marion, additional, Bataille, Mathieu, additional, Bonnet, Anne-Laure, additional, Cogez, Julien, additional, Touze, Emmanuel, additional, Leclerc, Xavier, additional, Leys, Didier, additional, Aggour, Mohamed, additional, Aguettaz, Pierre, additional, Bodenant, Marie, additional, Cordonnier, Charlotte, additional, Deplanque, Dominique, additional, Girot, Marie, additional, Henon, Hilde, additional, Kalsoum, Erwah, additional, Lucas, Christian, additional, Pruvo, Jean-Pierre, additional, Zuniga, Paolo, additional, Arquizan, Caroline, additional, Costalat, Vincent, additional, Machi, Paolo, additional, Mourand, Isabelle, additional, Riquelme, Carlos, additional, Bounolleau, Pierre, additional, Arteaga, Charles, additional, Faivre, Anthony, additional, Bintner, Marc, additional, Tournebize, Patrice, additional, Charlin, Cyril, additional, Darcel, Françoise, additional, Gauthier-Lasalarie, Pascale, additional, Jeremenko, Marcia, additional, Mouton, Servane, additional, Zerlauth, Jean-Baptiste, additional, Lamy, Chantal, additional, Hervé, Deramond, additional, Hassan, Hosseini, additional, Gaston, André, additional, Barral, Francis-Guy, additional, Garnier, Pierre, additional, Beaujeux, Rémy, additional, Wolff, Valérie, additional, Herbreteau, Denis, additional, Debiais, Séverine, additional, Murray, Alicia, additional, Ford, Gary, additional, Clifton, Andy, additional, Freeman, Janet, additional, Ford, Ian, additional, Markus, Hugh, additional, Wardlaw, Joanna, additional, Molyneux, Andy, additional, Robinson, Thompson, additional, Lewis, Steff, additional, Norrie, John, additional, Robertson, Fergus, additional, Perry, Richard, additional, Dixit, Anand, additional, Clifton, Andrew, additional, Roffe, Christine, additional, Nayak, Sanjeev, additional, Lobotesis, Kyriakos, additional, Smith, Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional
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- 2019
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125. Thrombectomy for acute ischemic stroke patients with isolated distal internal carotid artery occlusion: a retrospective observational study.
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Hoving, Jan W., Kappelhof, Manon, Schembri, Mark, Emmer, Bart J., Berkhemer, Olvert A., Groot, Adrien E. D., Dippel, Diederik W. J., van Zwam, Wim H., Coutinho, Jonathan M., Marquering, Henk A., Majoie, Charles B. L. M., and van den Berg, René
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ARTERIAL occlusions ,CAROTID artery diseases ,SCIENTIFIC observation ,BLOOD vessels ,CEREBRAL ventricles ,ISCHEMIC stroke ,RETROSPECTIVE studies ,VEIN surgery ,STROKE patients ,THROMBECTOMY ,COMPUTED tomography - Abstract
Purpose: Acute stroke patients presenting with a distal internal carotid artery occlusion and patent carotid terminus, allowing for collateral flow via the circle of Willis, may have a more favorable natural history. Therefore, benefit of endovascular treatment (EVT) is less evident. We performed an exploratory analysis of EVT results compared to conservative treatment in patients with 'carotid-I' occlusions. Methods: We report on EVT-treated and non-EVT-treated patients with carotid-I occlusions from the MR CLEAN Registry, MR CLEAN trial, and our comprehensive stroke center. CT-angiography was reviewed on primary collateral patency and choroid plexus enhancement. Perfusion deficits were assessed on CT-perfusion (CTP). Clot migration was assessed by comparing clot location on baseline CTA to its location on periprocedural digital subtraction angiography. Outcomes included 90-day functional independence (mRS 0–2), successful reperfusion and mortality. Results: We included 51 patients. Forty-one patients received EVT, ten patients did not. Intravenous thrombolysis was administered in 32 (78%) EVT-treated patients and 6 (60%) non-EVT-treated patients. CTP, available for 17 patients, showed hypoperfusion on cerebral blood flow maps in 13 (76%) patients. Successful reperfusion after EVT occurred in 23 (56%), and clot migration in 8 patients (20%). Functional independence was achieved in 54% (21/39) of EVT-treated and in 10% (1/10) of non-EVT-treated patients. Mortality was 26% (10/39) and 30% (3/10), respectively. Anterior choroidal artery patency and choroid plexus enhancement were positively associated with functional independence. Conclusion: In our population, data suggest improved outcomes after EVT in carotid-I occlusion patients and provide no arguments to withhold EVT in these patients. [ABSTRACT FROM AUTHOR]
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- 2021
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126. Validation of automated Alberta Stroke Program Early CT Score (ASPECTS) software for detection of early ischemic changes on non-contrast brain CT scans.
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Wolff, Lennard, Berkhemer, Olvert A., van Es, Adriaan C. G. M., van Zwam, Wim H., Dippel, Diederik W. J., Majoie, Charles B. L. M., van Walsum, Theo, and van der Lugt, Aad
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BRAIN , *CONSENSUS (Social sciences) , *DIGITAL image processing , *STROKE , *RESEARCH methodology evaluation , *RESEARCH methodology , *SOFTWARE architecture , *INTRACLASS correlation , *DESCRIPTIVE statistics , *COMPUTED tomography , *RECEIVER operating characteristic curves , *CEREBRAL ischemia - Abstract
Purpose: In ASPECTS, 10 brain regions are scored visually for presence of acute ischemic stroke damage. We evaluated automated ASPECTS in comparison to expert readers. Methods: Consecutive, baseline non-contrast CT-scans (5-mm slice thickness) from the prospective MR CLEAN trial (n = 459, MR CLEAN Netherlands Trial Registry number: NTR1804) were evaluated. A two-observer consensus for ASPECTS regions (normal/abnormal) was used as reference standard for training and testing (0.2/0.8 division). Two other observers provided individual ASPECTS-region scores. The Automated ASPECTS software was applied. A region score specificity of ≥ 90% was used to determine the software threshold for detection of an affected region based on relative density difference between affected and contralateral region. Sensitivity, specificity, and receiver-operating characteristic curves were calculated. Additionally, we assessed intraclass correlation coefficients (ICCs) for automated ASPECTS and observers in comparison to the reference standard in the test set. Results: In the training set (n = 104), with software thresholds for a specificity of ≥ 90%, we found a sensitivity of 33–49% and an area under the curve (AUC) of 0.741–0.785 for detection of an affected ASPECTS region. In the test set (n = 355), the results for the found software thresholds were 89–89% (specificity), 41–57% (sensitivity), and 0.750–0.795 (AUC). Comparison of automated ASPECTS with the reference standard resulted in an ICC of 0.526. Comparison of observers with the reference standard resulted in an ICC of 0.383–0.464. Conclusion: The performance of automated ASPECTS is comparable to expert readers and could support readers in the detection of early ischemic changes. [ABSTRACT FROM AUTHOR]
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- 2021
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127. Absence of Cortical Vein Opacification Is Associated with Lack of Intra-arterial Therapy Benefit in Stroke
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Jansen, Ivo G. H., van Vuuren, Annemieke B., van Zwam, Wim H., van den Wijngaard, Ido R., Berkhemer, Olvert A., Lingsma, Hester F., Slump, Cornelis H., van Oostenbrugge, Robert J., Treurniet, Kilian M., Dippel, Diederik W. J., van Walderveen, Marianne A. A., van der Lugt, Aad, Roos, Yvo B. W. E. M., Marquering, Henk A., Majoie, Charles B. L. M., van den Berg, Rene, MR CLEAN Trial Investigators, Jansen, Ivo G. H., van Vuuren, Annemieke B., van Zwam, Wim H., van den Wijngaard, Ido R., Berkhemer, Olvert A., Lingsma, Hester F., Slump, Cornelis H., van Oostenbrugge, Robert J., Treurniet, Kilian M., Dippel, Diederik W. J., van Walderveen, Marianne A. A., van der Lugt, Aad, Roos, Yvo B. W. E. M., Marquering, Henk A., Majoie, Charles B. L. M., van den Berg, Rene, and MR CLEAN Trial Investigators
- Abstract
Purpose: To assess the degree of cortical vein opacification in patients with internal carotid artery or middle cerebral artery (MCA) stroke and to evaluate the relationship with treatment benefit from intra-arterial therapy (IAT). Materials and Methods: Written informed consent was obtained from all patients in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands. From the trial's database, all patients (recruited from December 2010 until March 2014) with baseline computed tomographic (CT) angiograms were retrospectively included. Enhancement of the vein of Labbe, sphenoparietal sinus, and superficial middle cerebral vein was graded by one neuroradiologist, as follows: 0, not visible; 1, moderate opacification; and 2, full opacification. The sum for the ipsilateral hemisphere was calculated, resulting in the cortical vein opacification score (COVES) (range, 0-6). Primary outcome was the modified Rankin Scale score at 90 days. Association with treatment according to full cortical vein score and different dichotomized cutoff points was estimated with ordinal logistic regression. Interobserver agreement was assessed by two separate observers who reviewed 100 studies each. Results: In total, 397 patients were analyzed. Interaction of the cortical vein score with treatment was significant (P = .044) when dichotomized COVES was 0 versus more than 0. The adjusted odds ratio for shift toward better functional outcome was 1.0 (95% confidence interval [CI]: 0.5, 2.0) for a COVES of 0 (n = 123) and 2.2 (95% CI: 1.6, 4.1) for a COVES greater than 0 (n = 274). The multirater kappa value was 0.73. Conclusion: In this study, patients with acute middle cerebral artery stroke with absence of cortical vein opacification in the affected hemisphere (COVES = 0) appeared to have no benefit from IAT, whereas patients with venous opacification (COVES >0) were shown to benefit from IAT. (C) RSNA, 2017
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- 2018
128. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data
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Roman, Luis San, Menon, Bijoy K., Blasco, Jordi, Hernandez-Perez, Maria, Davalos, Antoni, Majoie, Charles B. L. M., Campbell, Bruce C. V., Guillemin, Francis, Lingsma, Hester, Anxionnat, Rene, Epstein, Jonathan, Saver, Jeffrey L., Marquering, Henk, Wong, John H., Lopes, Demetrius, Reimann, Gernot, Desal, Hubert, Dippel, Diederik W. J., Coutts, Shelagh, de Rochemont, Richard du Mesnil, Yavagal, Dileep, Ferre, Jean Christophe, Roos, Yvo B. W. E. M., Liebeskind, David S., Lenthall, Robert, Molina, Carlos, Al Ajlan, Fahad S., Reddy, Vivek, Dowlatshahi, Dar, Nader-Antoine, Sourour, Oppenheim, Catherine, Mitha, Alim P., Davis, Stephen M., Weimar, Christian, van Oostenbrugge, Robert J., Cobo, Erik, Kleinig, Timothy J., Donnan, Geoffrey A., van der Lugt, Aad, Demchuk, Andrew M., Berkhemer, Olvert A., Boers, Anna M. M., Ford, Gary A., Muir, Keith W., Brown, B. Scott, Jovin, Tudor, van Zwam, Wim H., Mitchell, Peter J., Hill, Michael D., White, Phil, Bracard, Serge, Goyal, Mayank, HERMES Collaboration, Roman, Luis San, Menon, Bijoy K., Blasco, Jordi, Hernandez-Perez, Maria, Davalos, Antoni, Majoie, Charles B. L. M., Campbell, Bruce C. V., Guillemin, Francis, Lingsma, Hester, Anxionnat, Rene, Epstein, Jonathan, Saver, Jeffrey L., Marquering, Henk, Wong, John H., Lopes, Demetrius, Reimann, Gernot, Desal, Hubert, Dippel, Diederik W. J., Coutts, Shelagh, de Rochemont, Richard du Mesnil, Yavagal, Dileep, Ferre, Jean Christophe, Roos, Yvo B. W. E. M., Liebeskind, David S., Lenthall, Robert, Molina, Carlos, Al Ajlan, Fahad S., Reddy, Vivek, Dowlatshahi, Dar, Nader-Antoine, Sourour, Oppenheim, Catherine, Mitha, Alim P., Davis, Stephen M., Weimar, Christian, van Oostenbrugge, Robert J., Cobo, Erik, Kleinig, Timothy J., Donnan, Geoffrey A., van der Lugt, Aad, Demchuk, Andrew M., Berkhemer, Olvert A., Boers, Anna M. M., Ford, Gary A., Muir, Keith W., Brown, B. Scott, Jovin, Tudor, van Zwam, Wim H., Mitchell, Peter J., Hill, Michael D., White, Phil, Bracard, Serge, Goyal, Mayank, and HERMES Collaboration
- Abstract
Background Evidence regarding whether imaging can be used effectively to select patients for endovascular thrombectomy (EVT) is scarce. We aimed to investigate the association between baseline imaging features and safety and efficacy of EVT in acute ischaemic stroke caused by anterior large-vessel occlusion. Methods In this meta-analysis of individual patient-level data, the HERMES collaboration identified in PubMed seven randomised trials in endovascular stroke that compared EVT with standard medical therapy, published between Jan 1, 2010, and Oct 31, 2017. Only trials that required vessel imaging to identify patients with proximal anterior circulation ischaemic stroke and that used predominantly stent retrievers or second-generation neurothrombectomy devices in the EVT group were included. Risk of bias was assessed with the Cochrane handbook methodology. Central investigators, masked to clinical information other than stroke side, categorised baseline imaging features of ischaemic change with the Alberta Stroke Program Early CT Score (ASPECTS) or according to involvement of more than 33% of middle cerebral artery territory, and by thrombus volume, hyperdensity, and collateral status. The primary endpoint was neurological functional disability scored on the modified Rankin Scale (mRS) score at 90 days after randomisation. Safety outcomes included symptomatic intracranial haemorrhage, parenchymal haematoma type 2 within 5 days of randomisation, and mortality within 90 days. For the primary analysis, we used mixed-methods ordinal logistic regression adjusted for age, sex, National Institutes of Health Stroke Scale score at admission, intravenous alteplase, and time from onset to randomisation, and we used interaction terms to test whether imaging categorisation at baseline modifies the association between treatment and outcome. This meta-analysis was prospectively designed by the HERMES executive committee but has not been registered. Findings Among 1764 pooled patie
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- 2018
129. A decrease in blood pressure is associated with unfavorable outcome in patients undergoing thrombectomy under general anesthesia
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Treurniet, Kilian M., Berkhemer, Olvert A., Immink, Rogier V., Lingsma, Hester F., Ward-van der Stam, Vivian M. C., Hollmann, Markus W., Vuyk, Jaap, van Zwam, Wim H., van der Lugt, Aad, van Oostenbrugge, Robert J., Dippel, Diederik W. J., Coutinho, Jonathan M., Roos, Yvo B. W. E. M., Marquering, Henk A., Majoie, Charles B. L. M., MR CLEAN Investigators, Treurniet, Kilian M., Berkhemer, Olvert A., Immink, Rogier V., Lingsma, Hester F., Ward-van der Stam, Vivian M. C., Hollmann, Markus W., Vuyk, Jaap, van Zwam, Wim H., van der Lugt, Aad, van Oostenbrugge, Robert J., Dippel, Diederik W. J., Coutinho, Jonathan M., Roos, Yvo B. W. E. M., Marquering, Henk A., Majoie, Charles B. L. M., and MR CLEAN Investigators
- Abstract
Background Up to two-thirds of patients are either dependent or dead 3months after thrombectomy for acute ischemic stroke (AIS). Loss of cerebral autoregulation may render patients with AIS vulnerable to decreases in mean arterial pressure (MAP). Objective To determine whether a fall in MAP during intervention under general anesthesia (GA) affects functional outcome. Methods This subgroup analysis included patients from the MR CLEAN trial treated with thrombectomy under GA. The investigated variables were the difference between MAP at baseline and average MAP during GA (MAP) as well as the difference between baseline MAP and the lowest MAP during GA (LMAP). Their association with a shift towards better outcome on the modified Rankin Scale (mRS) after 90days was determined using ordinal logistic regression with adjustment for prognostic baseline variables. Results Sixty of the 85 patients treated under GA in MR CLEAN had sufficient anesthetic information available for the analysis. A greater MAP was associated with worse outcome (adjusted common OR (acOR) 0.95 per point mmHg, 95% CI 0.92 to 0.99). An average MAP during GA 10mmHg lower than baseline MAP constituted a 1.67 times lower odds of a shift towards good outcome on the mRS. For LMAP this association was not significant (acOR 0.97 per mmHg, 95% CI 0.94 to 1.00, p=0.09). Conclusions A decrease in MAP during intervention under GA compared with baseline is associated with worse outcome. Trial registration number NTR1804; ISRCTN10888758; post-results.
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- 2018
130. Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke A Secondary Analysis of the MR CLEAN Trial
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Kimberly, W. Taylor, Dutra, Bruna Garbugio, Boers, Anna M. M., Alves, Heitor C. B. R., Berkhemer, Olvert A., van den Berg, Lucie, Sheth, Kevin N., Roos, Yvo B. W. E. M., van der Lugt, Aad, Beenen, Ludo F. M., Dippel, Diederik W. J., van Zwam, Wim H., van Oostenbrugge, Robert J., Lingsma, Hester F., Marquering, Henk, Majoie, Charles B. L. M., MR CLEAN Investigators, Kimberly, W. Taylor, Dutra, Bruna Garbugio, Boers, Anna M. M., Alves, Heitor C. B. R., Berkhemer, Olvert A., van den Berg, Lucie, Sheth, Kevin N., Roos, Yvo B. W. E. M., van der Lugt, Aad, Beenen, Ludo F. M., Dippel, Diederik W. J., van Zwam, Wim H., van Oostenbrugge, Robert J., Lingsma, Hester F., Marquering, Henk, Majoie, Charles B. L. M., and MR CLEAN Investigators
- Abstract
IMPORTANCE It is uncertain whether therapeutic reperfusion with endovascular treatment yields more or less brain edema. OBJECTIVE To elucidate the association between reperfusion and brain edema. The secondary objectives were to evaluate whether brain edema could partially be responsible for worse outcomes in patients with later reperfusion or lower Alberta Stroke Program Early Computed Tomography Score. DESIGN, SETTING, AND PARTICIPANTS This was a post hoc analysis of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN), which was a prospective, randomized, multicenter clinical trial of endovascular treatment compared with conventional care of patients with acute anterior circulation ischemic stroke. Of 502 patients enrolled from December 2010 to June 2014, 2 patients declined to participate. Additionally, exclusion criteria were absence of follow-up imaging or presence of parenchymal hematoma, resulting in 462 patients included in this study. Brain edema was assessed retrospectively, from December 10, 2016, to July 24, 2017, by measuring midline shift (MLS) in all available follow-up scans. Observers were blinded to clinical data. MAIN OUTCOMES AND MEASURES Midline shift was assessed as present or absent and as a continuous variable. Reperfusion status was assessed by the modified thrombolysis in cerebral infarction score in the endovascular treatment arm. The modified arterial occlusive lesion score was used to evaluate the recanalization status in both arms. The modified Rankin scale score at 90 days was used for functional outcome. RESULTS Of 462 patients, the mean (SD) age was 65 (11) years, and 41.8%(n = 193) were women. Successful reperfusion and recanalization were associated with a reduced likelihood of having MLS (adjusted common odds ratio, 0.25; 95% CI, 0.12-0.53; P < .001 and adjusted common odds ratio, 0.34; 95% CI, 0.21-0.55; P < .001, respectively). Midline shift was partia
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- 2018
131. Workflow and factors associated with delay in the delivery of intra-arterial treatment for acute ischemic stroke in the MR CLEAN trial
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Venema, Esmee, Boodt, Nikki, Berkhemer, Olvert, Rood, Pleunie, Zwam, WH, van Oostenbrugge, RJ, van der Lugt, Aad, Roos, Y, Majoie, C, Lingsma, Hester, Dippel, Diederik, Venema, Esmee, Boodt, Nikki, Berkhemer, Olvert, Rood, Pleunie, Zwam, WH, van Oostenbrugge, RJ, van der Lugt, Aad, Roos, Y, Majoie, C, Lingsma, Hester, and Dippel, Diederik
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- 2018
132. Intracranial Carotid Artery Calcification and Effect of Endovascular Stroke Treatment
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Compagne, Kars, Clephas, PRD, Majoie, CBLM, Roos, YBWEM, Berkhemer, Olvert, van Oostenbrugge, RJ, Zwam, WH, Es, Adriaan, Dippel, Diederik, van der Lugt, Aad, Bos, Daniel, Compagne, Kars, Clephas, PRD, Majoie, CBLM, Roos, YBWEM, Berkhemer, Olvert, van Oostenbrugge, RJ, Zwam, WH, Es, Adriaan, Dippel, Diederik, van der Lugt, Aad, and Bos, Daniel
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- 2018
133. A decrease in blood pressure is associated with unfavorable outcome in patients undergoing thrombectomy under general anesthesia
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Treurniet, KM, Berkhemer, Olvert, Immink, RV, Lingsma, Hester, Ward-van der Stam, VMC, Hollmann, MW, Vuyk, J, Zwam, WH, van der Lugt, Aad, van Oostenbrugge, RJ, Dippel, Diederik, Coutinho, J M, Roos, Y, Marquering, HA, Treurniet, KM, Berkhemer, Olvert, Immink, RV, Lingsma, Hester, Ward-van der Stam, VMC, Hollmann, MW, Vuyk, J, Zwam, WH, van der Lugt, Aad, van Oostenbrugge, RJ, Dippel, Diederik, Coutinho, J M, Roos, Y, and Marquering, HA
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- 2018
134. Associations Between Collateral Status and Thrombus Characteristics and Their Impact in Anterior Circulation Stroke
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Alves, HC, Treurniet, KM, Dutra, BG, Jansen, IGH, Boers, AMM, Santos, Emilie, Berkhemer, Olvert, Dippel, Diederik, van der Lugt, Aad, Zwam, WH, van Oostenbrugge, RJ, Lingsma, Hester, Roos, Y, Yoo, AJ, Marquering, HA, Majoie, C, Alves, HC, Treurniet, KM, Dutra, BG, Jansen, IGH, Boers, AMM, Santos, Emilie, Berkhemer, Olvert, Dippel, Diederik, van der Lugt, Aad, Zwam, WH, van Oostenbrugge, RJ, Lingsma, Hester, Roos, Y, Yoo, AJ, Marquering, HA, and Majoie, C
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- 2018
135. qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients.
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Prasetya, Haryadi, Ramos, Lucas A, Epema, Thabiso, Treurniet, Kilian M, Emmer, Bart J, van den Wijngaard, Ido R, Zhang, Guang, Kappelhof, Manon, Berkhemer, Olvert A, Yoo, Albert J, Roos, Yvo BEWM, van Oostenbrugge, Robert J, Dippel, Diederik WJ, van Zwam, Wim H, van der Lugt, Aad, de Mol, Bas AJM, Majoie, Charles BLM, Bavel, Ed van, and Marquering, Henk A
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STROKE patients ,DIGITAL subtraction angiography ,RECEIVER operating characteristic curves ,REPERFUSION ,INTERNAL carotid artery - Abstract
Background: The Thrombolysis in Cerebral Infarction (TICI) scale is an important outcome measure to evaluate the quality of endovascular stroke therapy. The TICI scale is ordinal and observer-dependent, which may result in suboptimal prediction of patient outcome and inconsistent reperfusion grading. Aims: We present a semi-automated quantitative reperfusion measure (quantified TICI (qTICI)) using image processing techniques based on the TICI methodology. Methods: We included patients with an intracranial proximal large vessel occlusion with complete, good quality runs of anteroposterior and lateral digital subtraction angiography from the MR CLEAN Registry. For each vessel occlusion, we identified the target downstream territory and automatically segmented the reperfused area in the target downstream territory on final digital subtraction angiography. qTICI was defined as the percentage of reperfused area in target downstream territory. The value of qTICI and extended TICI (eTICI) in predicting favorable functional outcome (modified Rankin Scale 0–2) was compared using area under receiver operating characteristics curve and binary logistic regression analysis unadjusted and adjusted for known prognostic factors. Results: In total, 408 patients with M1 or internal carotid artery occlusion were included. The median qTICI was 78 (interquartile range 58–88) and 215 patients (53%) had an eTICI of 2C or higher. qTICI was comparable to eTICI in predicting favorable outcome with area under receiver operating characteristics curve of 0.63 vs. 0.62 (P = 0.8) and 0.87 vs. 0.86 (P = 0.87), for the unadjusted and adjusted analysis, respectively. In the adjusted regression analyses, both qTICI and eTICI were independently associated with functional outcome. Conclusion: qTICI provides a quantitative measure of reperfusion with similar prognostic value for functional outcome to eTICI score. [ABSTRACT FROM AUTHOR]
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- 2021
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136. Added Prognostic Value of Hemorrhagic Transformation Quantification in Patients With Acute Ischemic Stroke.
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van Kranendonk, Katinka R., Treurniet, Kilian M., Boers, Anna M. M., Berkhemer, Olvert A., Coutinho, Jonathan M., Lingsma, Hester F., van Zwam, Wim H., van der Lugt, Aad, van Oostenbrugge, Robert J., Dippel, Diederik W. J., Roos, Yvo B. W. E. M., Marquering, Henk A., and Majoie, Charles B. L. M.
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STROKE patients ,PROGNOSIS - Abstract
Introduction and Aim: Hemorrhagic transformation (HT) frequently occurs after acute ischemic stroke and negatively influences the functional outcome. Usually, HT is classified by its radiological appearance. Discriminating between the subtypes can be complicated, and interobserver variation is considerable. Therefore, we aim to quantify rather than classify hemorrhage volumes and determine the association of hemorrhage volume with functional outcome in comparison with the European Cooperative Acute Stroke Study II classification. Patients and Methods: We included patients from the MR CLEAN trial with follow-up imaging. Hemorrhage volume was estimated by manual delineation of the lesion, and HT was classified according to the European Cooperative Acute Stroke Study II classification [petechial hemorrhagic infarction types 1 (HI1) and 2 (HI2) and parenchymal hematoma types 1 (PH1) and 2 (PH2)] on follow-up CT 24 h to 2 weeks after treatment. We assessed functional outcome using the modified Rankin Scale 90 days after stroke onset. Ordinal logistic regression with and without adjustment for potential confounders was used to describe the association of hemorrhage volume with functional outcome. We created regression models including and excluding total lesion volume as a confounder. Results: We included 478 patients. Of these patients, 222 had HT. Median hemorrhage volume was 3.37 ml (0.80–12.6) and per HT subgroup; HI1: 0.2 (0.0–1.7), HI2: 3.2 (1.7–6.1), PH1: 6.3 (4.2–13), and PH2: 47 (19–101). Hemorrhage volume was associated with functional outcome [adjusted common odds ratio (acOR): 0.83, 95% CI: 0.73–0.95] but not anymore after adjustment for total lesion volume (acOR: 0.99, 95% CI: 0.86–1.15, per 10 ml). Hemorrhage volume in patients with PH2 was significantly associated with functional outcome after adjusting total lesion volume (acOR: 0.70, 95% CI: 0.50–0.98). Conclusion: HT volume is associated with functional outcomes in patients with acute ischemic stroke but not independent of total lesion volume. The extent of a PH2 was associated with outcome, suggesting that measuring hemorrhage volume only provides an additional benefit in the prediction of the outcome when a PH2 is present. [ABSTRACT FROM AUTHOR]
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- 2020
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137. Automatic segmentation of cerebral infarcts in follow-up computed tomography images with convolutional neural networks.
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Sales Barros, Renan, Tolhuisen, Manon L., Boers, Anna M. M., Jansen, Ivo, Ponomareva, Elena, Dippel, Diederik W. J., van der Lugt, Aad, van Oostenbrugge, Robert J., van Zwam, Wim H., Berkhemer, Olvert A., Goyal, Mayank, Demchuk, Andrew M., Menon, Bijoy K., Mitchell, Peter, Hill, Michael D., Jovin, Tudor G., Davalos, Antoni, Campbell, Bruce C. V., Saver, Jeffrey L., and Roos, Yvo B. W. E. M.
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CEREBRAL infarction ,COMPUTED tomography ,CONFIDENCE intervals ,ISCHEMIA ,ARTIFICIAL neural networks ,STROKE ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,ODDS ratio ,INTRACLASS correlation - Abstract
Background and purpose Infarct volume is a valuable outcome measure in treatment trials of acute ischemic stroke and is strongly associated with functional outcome. Its manual volumetric assessment is, however, too demanding to be implemented in clinical practice. Objective To assess the value of convolutional neural networks (CNNs) in the automatic segmentation of infarct volume in follow-up CT images in a large population of patients with acute ischemic stroke. Materials and methods We included CT images of 1026 patients from a large pooling of patients with acute ischemic stroke. A reference standard for the infarct segmentation was generated by manual delineation. We introduce three CNN models for the segmentation of subtle, intermediate, and severe hypodense lesions. The fully automated infarct segmentation was defined as the combination of the results of these three CNNs. The results of the three-CNNs approach were compared with the results from a single CNN approach and with the reference standard segmentations. Results The median infarct volume was 48 mL (IQR 15-125 mL). Comparison between the volumes of the three-CNNs approach and manually delineated infarct volumes showed excellent agreement, with an intraclass correlation coefficient (ICC) of 0.88. Even better agreement was found for severe and intermediate hypodense infarcts, with ICCs of 0.98 and 0.93, respectively. Although the number of patients used for training in the single CNN approach was much larger, the accuracy of the three-CNNs approach strongly outperformed the single CNN approach, which had an ICC of 0.34. Conclusion Convolutional neural networks are valuable and accurate in the quantitative assessment of infarct volumes, for both subtle and severe hypodense infarcts in follow-up CT images. Our proposed three-CNNs approach strongly outperforms a more straightforward single CNN approach. [ABSTRACT FROM AUTHOR]
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- 2020
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138. Hemorrhagic transformation is associated with poor functional outcome in patients with acute ischemic stroke due to a large vessel occlusion
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van Kranendonk, Katinka R, primary, Treurniet, Kilian M, additional, Boers, Anna M M, additional, Berkhemer, Olvert A, additional, van den Berg, Lucie A, additional, Chalos, Vicky, additional, Lingsma, Hester F, additional, van Zwam, Wim H, additional, van der Lugt, Aad, additional, van Oostenbrugge, Robert J, additional, Dippel, Diederik W J, additional, Roos, Yvo B W E M, additional, Marquering, Henk A, additional, and Majoie, Charles B L M, additional
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- 2018
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139. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data
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Román, Luis San, primary, Menon, Bijoy K, additional, Blasco, Jordi, additional, Hernández-Pérez, María, additional, Dávalos, Antoni, additional, Majoie, Charles B L M, additional, Campbell, Bruce C V, additional, Guillemin, Francis, additional, Lingsma, Hester, additional, Anxionnat, René, additional, Epstein, Jonathan, additional, Saver, Jeffrey L, additional, Marquering, Henk, additional, Wong, John H, additional, Lopes, Demetrius, additional, Reimann, Gernot, additional, Desal, Hubert, additional, Dippel, Diederik W J, additional, Coutts, Shelagh, additional, du Mesnil de Rochemont, Richard, additional, Yavagal, Dileep, additional, Ferre, Jean Christophe, additional, Roos, Yvo B W E M, additional, Liebeskind, David S, additional, Lenthall, Robert, additional, Molina, Carlos, additional, Al Ajlan, Fahad S, additional, Reddy, Vivek, additional, Dowlatshahi, Dar, additional, Sourour, Nader-Antoine, additional, Oppenheim, Catherine, additional, Mitha, Alim P, additional, Davis, Stephen M, additional, Weimar, Christian, additional, van Oostenbrugge, Robert J, additional, Cobo, Erik, additional, Kleinig, Timothy J, additional, Donnan, Geoffrey A, additional, van der Lugt, Aad, additional, Demchuk, Andrew M, additional, Berkhemer, Olvert A, additional, Boers, Anna M M, additional, Ford, Gary A, additional, Muir, Keith W, additional, Brown, B Scott, additional, Jovin, Tudor, additional, van Zwam, Wim H, additional, Mitchell, Peter J, additional, Hill, Michael D, additional, White, Phil, additional, Bracard, Serge, additional, Goyal, Mayank, additional, Fransen, Puck SS, additional, Beumer, Debbie, additional, van den Berg, Lucie A, additional, Lingsma, Hester F, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, additional, Williams, J, additional, Wiegner, R, additional, Casaubon, LK, additional, Jaigobin, C, additional, del Campo, JM, additional, Elamin, E, additional, Schaafsma, JD, additional, Agid, R, additional, Farb, R, additional, ter Brugge, K, additional, Sapkoda, BL, additional, Baxter, BW, additional, Barton, K, additional, Knox, A, additional, Porter, A, additional, Sirelkhatim, A, additional, Devlin, T, additional, Dellinger, C, additional, Pitiyanuvath, N, additional, Patterson, J, additional, Nichols, J, additional, Quarfordt, S, additional, Calvert, J, additional, Hawk, H, additional, Fanale, C, additional, Bitner, A, additional, Novak, A, additional, Huddle, D, additional, Bellon, R, additional, Loy, D, additional, Wagner, J, additional, Chang, I, additional, Lampe, E, additional, Spencer, B, additional, Pratt, R, additional, Bartt, R, additional, Shine, S, additional, Dooley, G, additional, Nguyen, T, additional, Whaley, M, additional, McCarthy, K, additional, Teitelbaum, J, additional, Poon, W, additional, Campbell, N, additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez-Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, 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140. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
- Author
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Campbell, Bruce C V, primary, van Zwam, Wim H, additional, Goyal, Mayank, additional, Menon, Bijoy K, additional, Dippel, Diederik W J, additional, Demchuk, Andrew M, additional, Bracard, Serge, additional, White, Philip, additional, Dávalos, Antoni, additional, Majoie, Charles B L M, additional, van der Lugt, Aad, additional, Ford, Gary A, additional, de la Ossa, Natalia Pérez, additional, Kelly, Michael, additional, Bourcier, Romain, additional, Donnan, Geoffrey A, additional, Roos, Yvo B W E M, additional, Bang, Oh Young, additional, Nogueira, Raul G, additional, Devlin, Thomas G, additional, van den Berg, Lucie A, additional, Clarençon, Frédéric, additional, Burns, Paul, additional, Carpenter, Jeffrey, additional, Berkhemer, Olvert A, additional, Yavagal, Dileep R, additional, Pereira, Vitor Mendes, additional, Ducrocq, Xavier, additional, Dixit, Anand, additional, Quesada, Helena, additional, Epstein, Jonathan, additional, Davis, Stephen M, additional, Jansen, Olav, additional, Rubiera, Marta, additional, Urra, Xabier, additional, Micard, Emilien, additional, Lingsma, Hester F, additional, Naggara, Olivier, additional, Brown, Scott, additional, Guillemin, Francis, additional, Muir, Keith W, additional, van Oostenbrugge, Robert J, additional, Saver, Jeffrey L, additional, Jovin, Tudor G, additional, Hill, Michael D, additional, Mitchell, Peter J, additional, Fransen, Puck SS, additional, Beumer, Debbie, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, additional, Williams, J, additional, Wiegner, R, additional, Casaubon, LK, additional, Jaigobin, C, additional, del Campo, JM, additional, Elamin, E, additional, Schaafsma, JD, additional, Agid, R, additional, Farb, R, additional, ter Brugge, K, additional, Sapkoda, BL, additional, Baxter, BW, additional, Barton, K, additional, Knox, A, additional, Porter, A, additional, Sirelkhatim, A, additional, Devlin, T, additional, Dellinger, C, additional, Pitiyanuvath, N, additional, Patterson, J, additional, Nichols, J, additional, Quarfordt, S, additional, Calvert, J, additional, Hawk, H, additional, Fanale, C, additional, Bitner, A, additional, Novak, A, additional, Huddle, D, additional, Bellon, R, additional, Loy, D, additional, Wagner, J, additional, Chang, I, additional, Lampe, E, additional, Spencer, B, additional, Pratt, R, additional, Bartt, R, additional, Shine, S, additional, Dooley, G, additional, Nguyen, T, additional, Whaley, M, additional, McCarthy, K, additional, Teitelbaum, J, additional, Poon, W, additional, Campbell, N, additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez- Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, P, additional, Golob, D, additional, Gladstone, D, additional, Boyle, K, additional, Boulos, M, additional, Hopyan, J, additional, Yang, V, additional, Da Costa, L, additional, Holmstedt, CA, additional, Turk, AS, additional, Navarro, R, additional, Jauch, E, additional, Ozark, S, additional, Turner, R, additional, Phillips, S, additional, Shankar, J, additional, Jarrett, J, additional, Gubitz, G, additional, Maloney, W, additional, Vandorpe, R, additional, Schmidt, M, additional, Heidenreich, J, additional, Hunter, G, additional, Kelly, M, additional, Whelan, R, additional, Peeling, L, additional, Burns, PA, additional, Hunter, A, additional, Wiggam, I, additional, Kerr, E, additional, Watt, M, additional, Fulton, A, additional, Gordon, P, additional, Rennie, I, additional, Flynn, P, additional, Smyth, G, additional, O'Leary, S, additional, Gentile, N, additional, Linares, G, additional, McNelis, P, additional, Erkmen, K, additional, Katz, P, additional, Azizi, A, additional, Weaver, M, additional, Jungreis, C, additional, Faro, S, additional, Shah, P, additional, Reimer, H, additional, Kalugdan, V, additional, Saposnik, G, additional, Bharatha, A, additional, Li, Y, additional, Kostyrko, P, additional, Marotta, T, additional, Montanera, W, additional, Sarma, D, additional, Selchen, D, additional, Spears, J, additional, Heo, JH, additional, Jeong, K, additional, Kim, DJ, additional, Kim, BM, additional, Kim, YD, additional, Song, D, additional, Lee, K-J, additional, Yoo, J, additional, Bang, OY, additional, Rho, S, additional, Lee, J, additional, Jeon, P, additional, Kim, KH, additional, Cha, J, additional, Kim, SJ, additional, Ryoo, S, additional, Lee, MJ, additional, Sohn, S-I, additional, Kim, C-H, additional, Ryu, H-G, additional, Hong, J-H, additional, Chang, H-W, additional, Lee, C-Y, additional, Rha, J, additional, Campbell, Bruce CV, additional, Churilov, Leonid, additional, Yan, Bernard, additional, Dowling, Richard, additional, Yassi, Nawaf, additional, Oxley, Thomas J, additional, Wu, Teddy Y, additional, Silver, Gabriel, additional, McDonald, Amy, additional, McCoy, Rachael, additional, Kleinig, Timothy J, additional, Scroop, Rebecca, additional, Dewey, Helen M, additional, Simpson, Marion, additional, Brooks, Mark, additional, Coulton, Bronwyn, additional, Krause, Martin, additional, Harrington, Timothy J, additional, Steinfort, Brendan, additional, Faulder, Kenneth, additional, Priglinger, Miriam, additional, Day, Susan, additional, Phan, Thanh, additional, Chong, Winston, additional, Holt, Michael, additional, Chandra, Ronil V, additional, Ma, Henry, additional, Young, Dennis, additional, Wong, Kitty, additional, Wijeratne, Tissa, additional, Tu, Hans, additional, Mackay, Elizabeth, additional, Celestino, Sherisse, additional, Bladin, Christopher F, additional, Loh, Poh Sien, additional, Gilligan, Amanda, additional, Ross, Zofia, additional, Coote, Skye, additional, Frost, Tanya, additional, Parsons, Mark W, additional, Miteff, Ferdinand, additional, Levi, Christopher R, additional, Ang, Timothy, additional, Spratt, Neil, additional, Kaauwai, Lara, additional, Badve, Monica, additional, Rice, Henry, additional, de Villiers, Laetitia, additional, Barber, P. Alan, additional, McGuinness, Ben, additional, Hope, Ayton, additional, Moriarty, Maurice, additional, Bennett, Patricia, additional, Wong, Andrew, additional, Coulthard, Alan, additional, Lee, Andrew, additional, Jannes, Jim, additional, Field, Deborah, additional, Sharma, Gagan, additional, Salinas, Simon, additional, Cowley, Elise, additional, Snow, Barry, additional, Kolbe, John, additional, Stark, Richard, additional, King, John, additional, Macdonnell, Richard, additional, Attia, John, additional, D'Este, Cate, additional, Diener, Hans-Christoph, additional, Levy, Elad I., additional, Bonafé, Alain, additional, Mendes Pereira, Vitor, additional, Jahan, Reza, additional, Albers, Gregory W., additional, Cognard, Christophe, additional, Cohen, David J., additional, Hacke, Werner, additional, Jovin, Tudor G., additional, Mattle, Heinrich P., additional, Nogueira, Raul G., additional, Siddiqui, Adnan H., additional, Yavagal, Dileep R., additional, von Kummer, Rüdiger, additional, Smith, Wade, additional, Turjman, Francis, additional, Hamilton, Scott, additional, Chiacchierini, Richard, additional, Amar, Arun, additional, Sanossian, Nerses, additional, Loh, Yince, additional, Baxter, B, additional, Reddy, VK, additional, Horev, A, additional, Star, M, additional, Siddiqui, A, additional, Hopkins, LN, additional, Snyder, K, additional, Sawyer, R, additional, Hall, S, additional, Costalat, V, additional, Riquelme, C, additional, Machi, P, additional, Omer, E, additional, Arquizan, C, additional, Mourand, I, additional, Charif, M, additional, Ayrignac, X, additional, Menjot de Champfleur, N, additional, Leboucq, N, additional, Gascou, G, additional, Moynier, M, additional, du Mesnil de Rochemont, R, additional, Singer, O, additional, Berkefeld, J, additional, Foerch, C, additional, Lorenz, M, additional, Pfeilschifer, W, additional, Hattingen, E, additional, Wagner, M, additional, You, SJ, additional, Lescher, S, additional, Braun, H, additional, Dehkharghani, S, additional, Belagaje, SR, additional, Anderson, A, additional, Lima, A, additional, Obideen, M, additional, Haussen, D, additional, Dharia, R, additional, Frankel, M, additional, Patel, V, additional, Owada, K, additional, Saad, A, additional, Amerson, L, additional, Horn, C, additional, Doppelheuer, S, additional, Schindler, K, additional, Lopes, DK, additional, Chen, M, additional, Moftakhar, R, additional, Anton, C, additional, Smreczak, M, additional, Carpenter, JS, additional, Boo, S, additional, Rai, A, additional, Roberts, T, additional, Tarabishy, A, additional, Gutmann, L, additional, Brooks, C, additional, Brick, J, additional, Domico, J, additional, Reimann, G, additional, Hinrichs, K, additional, Becker, M, additional, Heiss, E, additional, Selle, C, additional, Witteler, A, additional, Al-Boutros, S, additional, Danch, M-J, additional, Ranft, A, additional, Rohde, S, additional, Burg, K, additional, Weimar, C, additional, Zegarac, V, additional, Hartmann, C, additional, Schlamann, M, additional, Göricke, S, additional, Ringlestein, A, additional, Wanke, I, additional, Mönninghoff, C, additional, Dietzold, M, additional, Budzik, R, additional, Davis, T, additional, Eubank, G, additional, Hicks, WJ, additional, Pema, P, additional, Vora, N, additional, Mejilla, J, additional, Taylor, M, additional, Clark, W, additional, Rontal, A, additional, Fields, J, additional, Peterson, B, additional, Nesbit, G, additional, Lutsep, H, additional, Bozorgchami, H, additional, Priest, R, additional, Ologuntoye, O, additional, Barnwell, S, additional, Dogan, A, additional, Herrick, K, additional, Takahasi, C, additional, Beadell, N, additional, Brown, B, additional, Jamieson, S, additional, Hussain, MS, additional, Russman, A, additional, Hui, F, additional, Wisco, D, additional, Uchino, K, additional, Khawaja, Z, additional, Katzan, I, additional, Toth, G, additional, Cheng-Ching, E, additional, Bain, M, additional, Man, S, additional, Farrag, A, additional, George, P, additional, John, S, additional, Shankar, L, additional, Drofa, A, additional, Dahlgren, R, additional, Bauer, A, additional, Itreat, A, additional, Taqui, A, additional, Cerejo, R, additional, Richmond, A, additional, Ringleb, P, additional, Bendszus, M, additional, Möhlenbruch, M, additional, Reiff, T, additional, Amiri, H, additional, Purrucker, J, additional, Herweh, C, additional, Pham, M, additional, Menn, O, additional, Ludwig, I, additional, Acosta, I, additional, Villar, C, additional, Morgan, W, additional, Sombutmai, C, additional, Hellinger, F, additional, Allen, E, additional, Bellew, M, additional, Gandhi, R, additional, Bonwit, E, additional, Aly, J, additional, Ecker, RD, additional, Seder, D, additional, Morris, J, additional, Skaletsky, M, additional, Belden, J, additional, Baker, C, additional, Connolly, LS, additional, Papanagiotou, P, additional, Roth, C, additional, Kastrup, A, additional, Politi, M, additional, Brunner, F, additional, Alexandrou, M, additional, Merdivan, H, additional, Ramsey, C, additional, Given II, C, additional, Renfrow, S, additional, Deshmukh, V, additional, Sasadeusz, K, additional, Vincent, F, additional, Thiesing, JT, additional, Putnam, J, additional, Bhatt, A, additional, Kansara, A, additional, Caceves, D, additional, Lowenkopf, T, additional, Yanase, L, additional, Zurasky, J, additional, Dancer, S, additional, Freeman, B, additional, Scheibe-Mirek, T, additional, Robison, J, additional, Roll, J, additional, Clark, D, additional, Rodriguez, M, additional, Fitzsimmons, B-FM, additional, Zaidat, O, additional, Lynch, JR, additional, Lazzaro, M, additional, Larson, T, additional, Padmore, L, additional, Das, E, additional, Farrow-Schmidt, A, additional, Hassan, A, additional, Tekle, W, additional, Cate, C, additional, Jansen, O, additional, Cnyrim, C, additional, Wodarg, F, additional, Wiese, C, additional, Binder, A, additional, Riedel, C, additional, Rohr, A, additional, Lang, N, additional, Laufs, H, additional, Krieter, S, additional, Remonda, L, additional, Diepers, M, additional, Añon, J, additional, Nedeltchev, K, additional, Kahles, T, additional, Biethahn, S, additional, Lindner, M, additional, Chang, V, additional, Gächter, C, additional, Esperon, C, additional, Guglielmetti, M, additional, Arenillas Lara, JF, additional, Martínez Galdámez, M, additional, Calleja Sanz, AI, additional, Cortijo Garcia, E, additional, Garcia Bermejo, P, additional, Perez, S, additional, Mulero Carrillo, P, additional, Crespo Vallejo, E, additional, Ruiz Piñero, M, additional, Lopez Mesonero, L, additional, Reyes Muñoz, FJ, additional, Brekenfeld, C, additional, Buhk, J-H, additional, Krützelmann, A, additional, Thomalla, G, additional, Cheng, B, additional, Beck, C, additional, Hoppe, J, additional, Goebell, E, additional, Holst, B, additional, Grzyska, U, additional, Wortmann, G, additional, Starkman, S, additional, Duckwiler, G, additional, Jahan, R, additional, Rao, N, additional, Sheth, S, additional, Ng, K, additional, Noorian, A, additional, Szeder, V, additional, Nour, M, additional, McManus, M, additional, Huang, J, additional, Tarpley, J, additional, Tateshima, S, additional, Gonzalez, N, additional, Ali, L, additional, Liebeskind, D, additional, Hinman, J, additional, Calderon-Arnulphi, M, additional, Liang, C, additional, Guzy, J, additional, Koch, S, additional, DeSousa, K, additional, Gordon-Perue, G, additional, Elhammady, M, additional, Peterson, E, additional, Pandey, V, additional, Dharmadhikari, S, additional, Khandelwal, P, additional, Malik, A, additional, Pafford, R, additional, Gonzalez, P, additional, Ramdas, K, additional, Andersen, G, additional, Damgaard, D, additional, Von Weitzel-Mudersbach, P, additional, Simonsen, C, additional, Ruiz de Morales Ayudarte, N, additional, Poulsen, M, additional, Sørensen, L, additional, Karabegovich, S, additional, Hjørringgaard, M, additional, Hjort, N, additional, Harbo, T, additional, Sørensen, K, additional, Deshaies, E, additional, Padalino, D, additional, Swarnkar, A, additional, Latorre, JG, additional, Elnour, E, additional, El-Zammar, Z, additional, Villwock, M, additional, Farid, H, additional, Balgude, A, additional, Cross, L, additional, Hansen, K, additional, Holtmannspötter, M, additional, Kondziella, D, additional, Hoejgaard, J, additional, Taudorf, S, additional, Soendergaard, H, additional, Wagner, A, additional, Cronquist, M, additional, Stavngaard, T, additional, Cortsen, M, additional, Krarup, LH, additional, Hyldal, T, additional, Haring, H-P, additional, Guggenberger, S, additional, Hamberger, M, additional, Trenkler, J, additional, Sonnberger, M, additional, Nussbaumer, K, additional, Dominger, C, additional, Bach, E, additional, Jagadeesan, BD, additional, Taylor, R, additional, Kim, J, additional, Shea, K, additional, Tummala, R, additional, Zacharatos, H, additional, Sandhu, D, additional, Ezzeddine, M, additional, Grande, A, additional, Hildebrandt, D, additional, Miller, K, additional, Scherber, J, additional, Hendrickson, A, additional, Jumaa, M, additional, Zaidi, S, additional, Hendrickson, T, additional, Snyder, V, additional, Killer-Oberpfalzer, M, additional, Mutzenbach, J, additional, Weymayr, F, additional, Broussalis, E, additional, Stadler, K, additional, Jedlitschka, A, additional, Malek, A, additional, Mueller-Kronast, N, additional, Beck, P, additional, Martin, C, additional, Summers, D, additional, Day, J, additional, Bettinger, I, additional, Holloway, W, additional, Olds, K, additional, Arkin, S, additional, Akhtar, N, additional, Boutwell, C, additional, Crandall, S, additional, Schwartzman, M, additional, Weinstein, C, additional, Brion, B, additional, Prothmann, S, additional, Kleine, J, additional, Kreiser, K, additional, Boeckh-Behrens, T, additional, Poppert, H, additional, Wunderlich, S, additional, Koch, ML, additional, Biberacher, V, additional, Huberle, A, additional, Gora-Stahlberg, G, additional, Knier, B, additional, Meindl, T, additional, Utpadel-Fischler, D, additional, Zech, M, additional, Kowarik, M, additional, Seifert, C, additional, Schwaiger, B, additional, Puri, A, additional, Hou, S, additional, Wakhloo, A, additional, Moonis, M, additional, Henninger, N, additional, Goddeau, R, additional, Massari, F, additional, Minaeian, A, additional, Lozano, JD, additional, Ramzan, M, additional, Stout, C, additional, Patel, A, additional, Tunguturi, A, additional, Onteddu, S, additional, Carandang, R, additional, Howk, M, additional, Ribó, M, additional, Sanjuan, E, additional, Rubiera, M, additional, Pagola, J, additional, Flores, A, additional, Muchada, M, additional, Meler, P, additional, Huerga, E, additional, Gelabert, S, additional, Coscojuela, P, additional, Tomasello, A, additional, Rodriguez, D, additional, Santamarina, E, additional, Maisterra, O, additional, Boned, S, additional, Seró, L, additional, Rovira, A, additional, Molina, CA, additional, Millán, M, additional, Muñoz, L, additional, Pérez de la Ossa, N, additional, Gomis, M, additional, Dorado, L, additional, López-Cancio, E, additional, Palomeras, E, additional, Munuera, J, additional, García Bermejo, P, additional, Remollo, S, additional, Castaño, C, additional, García-Sort, R, additional, Cuadras, P, additional, Puyalto, P, additional, Hernández-Pérez, M, additional, Jiménez, M, additional, Martínez-Piñeiro, A, additional, Lucente, G, additional, Dávalos, A, additional, Chamorro, A, additional, Urra, X, additional, Obach, V, additional, Cervera, A, additional, Amaro, S, additional, Llull, L, additional, Codas, J, additional, Balasa, M, additional, Navarro, J, additional, Ariño, H, additional, Aceituno, A, additional, Rudilosso, S, additional, Renu, A, additional, Macho, JM, additional, San Roman, L, additional, Blasco, J, additional, López, A, additional, Macías, N, additional, Cardona, P, additional, Quesada, H, additional, Rubio, F, additional, Cano, L, additional, Lara, B, additional, de Miquel, MA, additional, Aja, L, additional, Serena, J, additional, Cobo, E, additional, Albers, Gregory W, additional, Lees, Kennedy R, additional, Arenillas, J, additional, Roberts, R, additional, Al-Ajlan, F, additional, Zimmel, L, additional, Patel, S, additional, Martí-Fàbregas, J, additional, Salvat-Plana, M, additional, Bracard, S, additional, Anxionnat, René, additional, Baillot, Pierre-Alexandre, additional, Barbier, Charlotte, additional, Derelle, Anne-Laure, additional, Lacour, Jean-Christophe, additional, Richard, Sébastien, additional, Samson, Yves, additional, Sourour, Nader, additional, Baronnet-Chauvet, Flore, additional, Clarencon, Frédéric, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Di Maria, Federico, additional, Le Bouc, Raphael, additional, Leger, Anne, additional, Mutlu, Gurkan, additional, Rosso, Charlotte, additional, Szatmary, Zoltan, additional, Yger, Marion, additional, Zavanone, Chiara, additional, Bakchine, Serge, additional, Pierot, Laurent, additional, Caucheteux, Nathalie, additional, Estrade, Laurent, additional, Kadziolka, Krzysztof, additional, Leautaud, Alexandre, additional, Renkes, Céline, additional, Serre, Isabelle, additional, Desal, Hubert, additional, Guillon, Benoît, additional, Boutoleau-Bretonniere, Claire, additional, Daumas-Duport, Benjamin, additional, De Gaalon, Solène, additional, Derkinderen, Pascal, additional, Evain, Sarah, additional, Herisson, Fanny, additional, Laplaud, David-Axel, additional, Lebouvier, Thibaud, additional, Lintia-Gaultier, Alina, additional, Pouclet-Courtemanche, Hélène, additional, Rouaud, Tiphaine, additional, Rouaud Jaffrenou, Violaine, additional, Schunck, Aurélia, additional, Sevin-Allouet, Mathieu, additional, Toulgoat, Frederique, additional, Wiertlewski, Sandrine, additional, Gauvrit, Jean-Yves, additional, Ronziere, Thomas, additional, Cahagne, Vincent, additional, Ferre, Jean-Christophe, additional, Pinel, Jean-François, additional, Raoult, Hélène, additional, Mas, Jean-Louis, additional, Meder, Jean-François, additional, Al Najjar-Carpentier, Amen-Adam, additional, Birchenall, Julia, additional, Bodiguel, Eric, additional, Calvet, David, additional, Domigo, Valérie, additional, Godon-Hardy, Sylvie, additional, Guiraud, Vincent, additional, Lamy, Catherine, additional, Majhadi, Loubna, additional, Morin, Ludovic, additional, Trystram, Denis, additional, Turc, Guillaume, additional, Berge, Jérôme, additional, Sibon, Igor, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Rouanet, François, additional, Debruxelles, Sabrina, additional, Kazadi, Annabelle, additional, Renou, Pauline, additional, Fleury, Olivier, additional, Pasco-Papon, Anne, additional, Dubas, Frédéric, additional, Caroff, Jildaz, additional, Godard Ducceschi, Sophie, additional, Hamon, Marie-Aurélie, additional, Lecluse, Alderic, additional, Marc, Guillaume, additional, Giroud, Maurice, additional, Ricolfi, Frédéric, additional, Bejot, Yannick, additional, Chavent, Adrien, additional, Gentil, Arnaud, additional, Kazemi, Apolline, additional, Osseby, Guy-Victor, additional, Voguet, Charlotte, additional, Mahagne, Marie-Hélène, additional, Sedat, Jacques, additional, Chau, Yves, additional, Suissa, Laurent, additional, Lachaud, Sylvain, additional, Houdart, Emmanuel, additional, Stapf, Christian, additional, Buffon Porcher, Frédérique, additional, Chabriat, Hugues, additional, Guedin, Pierre, additional, Herve, Dominique, additional, Jouvent, Eric, additional, Mawet, Jérôme, additional, Saint-Maurice, Jean-Pierre, additional, Schneble, Hans-Martin, additional, Nighoghossian, Norbert, additional, Berhoune, Nadia-Nawel, additional, Bouhour, Françoise, additional, Cho, Tae-Hee, additional, Derex, Laurent, additional, Felix, Sandra, additional, Gervais-Bernard, Hélène, additional, Gory, Benjamin, additional, Manera, Luis, additional, Mechtouff, Laura, additional, Ritzenthaler, Thomas, additional, Riva, Roberto, additional, Salaris Silvio, Fabrizio, additional, Tilikete, Caroline, additional, Blanc, Raphael, additional, Obadia, Michaël, additional, Bartolini, Mario Bruno, additional, Gueguen, Antoine, additional, Piotin, Michel, additional, Pistocchi, Silvia, additional, Redjem, Hocine, additional, Drouineau, Jacques, additional, Neau, Jean-Philippe, additional, Godeneche, Gaelle, additional, Lamy, Matthias, additional, Marsac, Emilia, additional, Velasco, Stephane, additional, Clavelou, Pierre, additional, Chabert, Emmanuel, additional, Bourgois, Nathalie, additional, Cornut-Chauvinc, Catherine, additional, Ferrier, Anna, additional, Gabrillargues, Jean, additional, Jean, Betty, additional, Marques, Anna-Raquel, additional, Vitello, Nicolas, additional, Detante, Olivier, additional, Barbieux, Marianne, additional, Boubagra, Kamel, additional, Favre Wiki, Isabelle, additional, Garambois, Katia, additional, Tahon, Florence, additional, Ashok, Vasdev, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Lapergue, Bertrand, additional, Bourdain, Frédéric, additional, Evrard, Serge, additional, Graveleau, Philippe, additional, Decroix, Jean Pierre, additional, Wang, Adrien, additional, Sellal, François, additional, Ahle, Guido, additional, Carelli, Gabriela, additional, Dugay, Marie-Hélène, additional, Gaultier, Claude, additional, Lebedinsky, Ariel Pablo, additional, Lita, Lavinia, additional, Musacchio, Raul Mariano, additional, Renglewicz-Destuynder, Catherine, additional, Tournade, Alain, additional, Vuillemet, Françis, additional, Montoro, Francisco Macian, additional, Mounayer, Charbel, additional, Faugeras, Frederic, additional, Gimenez, Laetitia, additional, Labach, Catherine, additional, Lautrette, Géraldine, additional, Denier, Christian, additional, Saliou, Guillaume, additional, Chassin, Olivier, additional, Dussaule, Claire, additional, Melki, Elsa, additional, Ozanne, Augustin, additional, Puccinelli, Francesco, additional, Sachet, Marina, additional, Sarov, Mariana, additional, Bonneville, Jean-François, additional, Moulin, Thierry, additional, Biondi, Alessandra, additional, De Bustos Medeiros, Elisabeth, additional, Vuillier, Fabrice, additional, Courtheoux, Patrick, additional, Viader, Fausto, additional, Apoil-Brissard, Marion, additional, Bataille, Mathieu, additional, Bonnet, Anne-Laure, additional, Cogez, Julien, additional, Touze, Emmanuel, additional, Leclerc, Xavier, additional, Leys, Didier, additional, Aggour, Mohamed, additional, Aguettaz, Pierre, additional, Bodenant, Marie, additional, Cordonnier, Charlotte, additional, Deplanque, Dominique, additional, Girot, Marie, additional, Henon, Hilde, additional, Kalsoum, Erwah, additional, Lucas, Christian, additional, Pruvo, Jean-Pierre, additional, Zuniga, Paolo, additional, Arquizan, Caroline, additional, Costalat, Vincent, additional, Machi, Paolo, additional, Mourand, Isabelle, additional, Riquelme, Carlos, additional, Bounolleau, Pierre, additional, Arteaga, Charles, additional, Faivre, Anthony, additional, Bintner, Marc, additional, Tournebize, Patrice, additional, Charlin, Cyril, additional, Darcel, Françoise, additional, Gauthier-Lasalarie, Pascale, additional, Jeremenko, Marcia, additional, Mouton, Servane, additional, Zerlauth, Jean-Baptiste, additional, Lamy, Chantal, additional, Hervé, Deramond, additional, Hassan, Hosseini, additional, Gaston, André, additional, Barral, Francis-Guy, additional, Garnier, Pierre, additional, Beaujeux, Rémy, additional, Wolff, Valérie, additional, Herbreteau, Denis, additional, Debiais, Séverine, additional, Murray, Alicia, additional, Ford, Gary, additional, Brown, Martin M, additional, Clifton, Andy, additional, Freeman, Janet, additional, Ford, Ian, additional, Markus, Hugh, additional, Wardlaw, Joanna, additional, Molyneux, Andy, additional, Robinson, Thompson, additional, Lewis, Steff, additional, Norrie, John, additional, Robertson, Fergus, additional, Perry, Richard, additional, Cloud, Geoffrey, additional, Clifton, Andrew, additional, Madigan, Jeremy, additional, Roffe, Christine, additional, Nayak, Sanjeev, additional, Lobotesis, Kyriakos, additional, Smith, Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional
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- 2018
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141. Quality of life after intra-arterial treatment for acute ischemic stroke in the MR CLEAN trialUpdate
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Schreuders, Jennifer, Berg, LA, Fransen, Puck, Berkhemer, Olvert, Beumer, Debbie, Lingsma, Hester, van Oostenbrugge, RJ, Zwam, WH, Majoie, C, van der Lugt, Aad, de Kort, PLM, Roos, Y, Dippel, Diederik, Schreuders, Jennifer, Berg, LA, Fransen, Puck, Berkhemer, Olvert, Beumer, Debbie, Lingsma, Hester, van Oostenbrugge, RJ, Zwam, WH, Majoie, C, van der Lugt, Aad, de Kort, PLM, Roos, Y, and Dippel, Diederik
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- 2017
142. Value of Thrombus CT Characteristics in Patients with Acute Ischemic Stroke
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Borst, J, Berkhemer, Olvert, Santos, Emilie, Yoo, AJ, den Blanken, M, Roos, Y, van Bavel, E, Zwam, WH, van Oostenbrugge, RJ, Lingsma, Hester, van der Lugt, Aad, Dippel, Diederik, Marquering, HA, Majoie, C, Borst, J, Berkhemer, Olvert, Santos, Emilie, Yoo, AJ, den Blanken, M, Roos, Y, van Bavel, E, Zwam, WH, van Oostenbrugge, RJ, Lingsma, Hester, van der Lugt, Aad, Dippel, Diederik, Marquering, HA, and Majoie, C
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- 2017
143. Selection of patients for intra-arterial treatment for acute ischaemic stroke: development and validation of a clinical decision tool in two randomised trials
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Venema, Esmee, Mulder, Maxim, Roozenbeek, Bob, Broderick, JP, Yeatts, SD, Khatri, P, Berkhemer, Olvert, Emmer, Bart, Roos, YBWEM, Majoie, C, van Oostenbrugge, RJ, Zwam, WH, van der Lugt, Aad, Steyerberg, Ewout, Dippel, Diederik, Lingsma, Hester, Venema, Esmee, Mulder, Maxim, Roozenbeek, Bob, Broderick, JP, Yeatts, SD, Khatri, P, Berkhemer, Olvert, Emmer, Bart, Roos, YBWEM, Majoie, C, van Oostenbrugge, RJ, Zwam, WH, van der Lugt, Aad, Steyerberg, Ewout, Dippel, Diederik, and Lingsma, Hester
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- 2017
144. Towards personalised intra- arterial treatment of patients with acute ischaemic stroke: a study protocol for development and validation of a clinical decision aid
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Mulder, Maxim, Venema, Esmee, Roozenbeek, Bob, Broderick, JP, Yeatts, SD, Khatri, P, Berkhemer, Olvert, Roos, Y, Majoie, C, van Oostenbrugge, RJ, van Zwam, WH, van der Lugt, Aad, Steyerberg, Ewout, Dippel, Diederik, Lingsma, Hester, Mulder, Maxim, Venema, Esmee, Roozenbeek, Bob, Broderick, JP, Yeatts, SD, Khatri, P, Berkhemer, Olvert, Roos, Y, Majoie, C, van Oostenbrugge, RJ, van Zwam, WH, van der Lugt, Aad, Steyerberg, Ewout, Dippel, Diederik, and Lingsma, Hester
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- 2017
145. Two-year clinical follow-up of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands (MR CLEAN): design and statistical analysis plan of the extended follow-up study
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van den Berg, LA, Dijkgraaf, MGW, Berkhemer, Olvert, Fransen, Puck, Beumer, D, Lingsma, Hester, Majoie, C B M, Dippel, Diederik, van der Lugt, Aad, van Oostenbrugge, RJ, Zwam, WH, Roos, YBWEM, Invesigators, Mr Clean, MUMC+: MA AIOS Neurologie (9), MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, RS: CARIM - R3.03 - Cerebral small vessel disease, RS: CARIM - R3.11 - Imaging, Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), ANS - Neurovascular Disorders, Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Amsterdam Public Health, Clinical Research Unit, Radiology and Nuclear Medicine, ACS - Amsterdam Cardiovascular Sciences, Neurology, Public Health, Radiology & Nuclear Medicine, Radiology and nuclear medicine, and Amsterdam Neuroscience - Neurovascular Disorders
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Male ,Research design ,Time Factors ,Medicine (miscellaneous) ,Kaplan-Meier Estimate ,Brain Ischemia ,law.invention ,Brain ischemia ,Disability Evaluation ,0302 clinical medicine ,Clinical Protocols ,Randomized controlled trial ,Risk Factors ,law ,Modified Rankin Scale ,Thrombolytic Therapy ,Pharmacology (medical) ,030212 general & internal medicine ,Stroke ,Netherlands ,Thrombectomy ,Aged, 80 and over ,Endovascular Procedures ,Treatment Outcome ,Research Design ,Cerebrovascular Circulation ,Data Interpretation, Statistical ,Female ,Stents ,medicine.medical_specialty ,Acute ischemic stroke ,Update ,Intravenous thrombolysis ,03 medical and health sciences ,medicine ,Humans ,Endovascular treatment ,cardiovascular diseases ,Artery occlusion ,Aged ,Proportional Hazards Models ,Proportional hazards model ,business.industry ,Recovery of Function ,medicine.disease ,Surgery ,Clinical trial ,Logistic Models ,Multivariate Analysis ,Mechanical thrombectomy ,business ,030217 neurology & neurosurgery - Abstract
MR CLEAN was the first randomized trial to demonstrate the short-term clinical effectiveness of endovascular treatment in patients with acute ischemic stroke caused by large vessel occlusion in the anterior circulation. Several other trials confirmed that endovascular treatment improves clinical outcome at three months. However, limited data are available on long-term clinical outcome. We aimed to estimate the effect of endovascular treatment on functional outcome at two-year follow-up in patients with acute ischemic stroke. Secondly, we aimed to assess the effect of endovascular treatment on major vascular events and mortality during two years of follow-up. MR CLEAN is a multicenter clinical trial with randomized treatment allocation, open-label treatment, and blinded endpoint evaluation. Patients included were 18 years or older with acute ischemic stroke caused by a proven anterior proximal artery occlusion who could be treated within six hours after stroke onset. The intervention contrast was endovascular treatment and usual care versus no endovascular treatment and usual care. The current study extended the follow-up duration from three months to two years. The primary outcome is the score on the modified Rankin scale at two years. Secondary outcomes include all-cause mortality and the occurrence of major vascular events within two years of follow-up. The results of our study provide information on the long-term clinical effectiveness of endovascular treatment, which may have implications for individual treatment decisions and estimates of cost-effectiveness. NTR1804 . Registered on 7 May 2009; ISRCTN10888758 . Registered on 24 July 2012 (main MR CLEAN trial); NTR5073 . Registered on 26 February 2015 (extended follow-up study).
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- 2016
146. Time to Reperfusion and Treatment Effect for Acute Ischemic Stroke : A Randomized Clinical Trial
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Fransen, Puck S S, Berkhemer, Olvert A, Lingsma, Hester F, Beumer, Debbie, van den Berg, Lucie A, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke J H, van Walderveen, Marianne A A, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A, Lycklama À Nijeholt, Geert J, Boiten, Jelis, Brouwer, Patrick A, Emmer, Bart J, de Bruijn, Sebastiaan F, van Dijk, Lukas C, Kappelle, L Jaap, Lo, Rob H, van Dijk, Ewoud J, de Vries, Joost, de Kort, Paul L M, van den Berg, J S Peter, van Hasselt, Boudewijn A A M, Aerden, Leo A M, Dallinga, René J, Visser, Marieke C, Bot, Joseph C J, Vroomen, Patrick C, Eshghi, Omid, Schreuder, Tobien H C M L, Heijboer, Roel J J, Keizer, Koos, Tielbeek, Alexander V, den Hertog, Heleen M, Gerrits, Dick G, van den Berg-Vos, Renske M, Karas, Giorgos B, Steyerberg, Ewout W, Flach, H Zwenneke, Marquering, Henk A, Sprengers, Marieke E S, Jenniskens, Sjoerd F M, Beenen, Ludo F M, van den Berg, René, Koudstaal, Peter J, van Zwam, Wim H, and Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands (MR CLEAN) investigators
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Multicenter Study ,Research Support, Non-U.S. Gov't ,Randomized Controlled Trial ,Journal Article - Abstract
Importance: Intra-arterial treatment (IAT) for acute ischemic stroke caused by intracranial arterial occlusion leads to improved functional outcome in patients treated within 6 hours after onset. The influence of treatment delay on treatment effect is not yet known. Objective: To evaluate the influence of time from stroke onset to the start of treatment and from stroke onset to reperfusion on the effect of IAT. Design, Setting, and Participants: The Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands (MR CLEAN) was a multicenter, randomized clinical open-label trial of IAT vs no IAT in 500 patients. The time to the start of treatment was defined as the time from onset of symptoms to groin puncture (TOG). The time from onset of treatment to reperfusion (TOR) was defined as the time to reopening the vessel occlusion or the end of the procedure in cases for which reperfusion was not achieved. Data were collected from December 3, 2010, to June 3, 2014, and analyzed (intention to treat) from July 1, 2014, to September 19, 2015. Main Outcomes and Measures: Main outcome was the modified Rankin Scale (mRS) score for functional outcome (range, 0 [no symptoms] to 6 [death]). Multiple ordinal logistic regression analysis estimated the effect of treatment and tested for the interaction of time to randomization, TOG, and TOR with treatment. The effect of treatment as a risk difference on reaching independence (mRS score, 0-2) was computed as a function of TOG and TOR. Calculations were adjusted for age, National Institutes of Health Stroke Scale score, previous stroke, atrial fibrillation, diabetes mellitus, and intracranial arterial terminus occlusion. Results: Among 500 patients (58% male; median age, 67 years), the median TOG was 260 (interquartile range [IQR], 210-311) minutes; median TOR, 340 (IQR, 274-395) minutes. An interaction between TOR and treatment (P = .04) existed, but not between TOG and treatment (P = .26). The adjusted risk difference (95% CI) was 25.9% (8.3%-44.4%) when reperfusion was reached at 3 hours, 18.8% (6.6%-32.6%) at 4 hours, and 6.7% (0.4%-14.5%) at 6 hours. Conclusion and Relevance: For every hour of reperfusion delay, the initially large benefit of IAT decreases; the absolute risk difference for a good outcome is reduced by 6% per hour of delay. Patients with acute ischemic stroke require immediate diagnostic workup and IAT in case of intracranial arterial vessel occlusion. Trial Registration: trialregister.nl Identifier: NTR1804.
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- 2016
147. Automated Entire Thrombus Density Measurements for Robust and Comprehensive Thrombus Characterization in Patients with Acute Ischemic Stroke
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Santos, Emilie M. M., Niessen, Wiro J., Yoo, Albert J., Berkhemer, Olvert A., Beenen, Ludo F., Majoie, Charles B., Marquering, Henk A., Fransen, Puck S. S., Beumer, Debbie, van den Berg, Lucie A., Lingsma, Hester F., Schonewille, Wouter J., Vos, Jan Albert, Nederkoorn, Paul J., Wermer, Marieke J. H., van Walderveen, Marianne A. A., Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, L. Jaap, Lo, Rob H., van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L. M., van den Berg, Jan S. P., van Hasselt, Boudewijn A. A. M., Aerden, Leo A. M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C. J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H. C. M. L., Heijboer, Roel J. J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Sprengers, Marieke E. S., van den Berg, René, Roos, Yvo B. W. E. M., Other departments, Radiology and Nuclear Medicine, ACS - Amsterdam Cardiovascular Sciences, ANS - Neurovascular Disorders, Graduate School, Other Research, Biomedical Engineering and Physics, Neurology, Public and occupational health, EMGO - Quality of care, Radiology and nuclear medicine, Amsterdam Neuroscience - Neurovascular Disorders, Medical Informatics, Radiology & Nuclear Medicine, MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, RS: CARIM - R3.03 - Cerebral small vessel disease, Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), and RS: CARIM - R3.11 - Imaging
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Male ,medicine.medical_specialty ,lcsh:Medicine ,Research Support ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Interquartile range ,Linear regression ,medicine ,Journal Article ,Humans ,cardiovascular diseases ,Thrombus ,Absorptiometry ,lcsh:Science ,Non-U.S. Gov't ,Stroke ,Acute ischemic stroke ,Tomography ,Aged ,Multidisciplinary ,business.industry ,Research Support, Non-U.S. Gov't ,lcsh:R ,Thrombosis ,Cerebral Arteries ,Middle Aged ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,medicine.disease ,Photon ,Internal ,X-Ray Computed ,Kurtosis ,cardiovascular system ,lcsh:Q ,Female ,Radiology ,Carotid Artery ,Tomography, X-Ray Computed ,business ,Carotid Artery, Internal ,030217 neurology & neurosurgery ,Research Article ,circulatory and respiratory physiology - Abstract
Contains fulltext : 168317.PDF (Publisher’s version ) (Open Access) BACKGROUND AND PURPOSE: In acute ischemic stroke (AIS) management, CT-based thrombus density has been associated with treatment success. However, currently used thrombus measurements are prone to inter-observer variability and oversimplify the heterogeneous thrombus composition. Our aim was first to introduce an automated method to assess the entire thrombus density and then to compare the measured entire thrombus density with respect to current standard manual measurements. MATERIALS AND METHOD: In 135 AIS patients, the density distribution of the entire thrombus was determined. Density distributions were described using medians, interquartile ranges (IQR), kurtosis, and skewedness. Differences between the median of entire thrombus measurements and commonly applied manual measurements using 3 regions of interest were determined using linear regression. RESULTS: Density distributions varied considerably with medians ranging from 20.0 to 62.8 HU and IQRs ranging from 9.3 to 55.8 HU. The average median of the thrombus density distributions (43.5 +/- 10.2 HU) was lower than the manual assessment (49.6 +/- 8.0 HU) (p
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- 2016
148. Erratum : Endovascular therapy is effective and safe for patients with severe ischemic stroke: Pooled analysis of Interventional Management of Stroke III and Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands Data (Stroke (2015) 46 (3416-3422) DOI: 10.1161/STROKEAHA.115.011397)
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Broderick, Joseph P., Berkhemer, Olvert A., Palesch, Yuko Y., Dippel, Diederik W J, Foster, Lydia D., Roos, Y.B.W.E.M., van der Lugt, A., Tomsick, Thomas A., Majoie, Charles B L M, van Zwam, Wim H, Demchuk, Andrew M., van Oostenbrugge, R. J., Khatri, Pooja, Lingsma, Hester F., Hill, Michael D., Roozenbeek, Bob, Jauch, Edward C., Jovin, Tudor G., Yan, Bernard, von Kummer, R., Molina, Carlos A., Goyal, Mayank, Schonewille, Wouter J., Mazighi, M., Engelter, Stefan T., Anderson, Craig S., Spilker, Judith, Carrozzella, Janice, Ryckborst, Karla J., Janis, L. Scott, and Simpson, Kit N.
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Published Erratum ,Clinical Neurology ,Advanced and Specialised Nursing ,Cardiology and Cardiovascular Medicine - Published
- 2016
149. Time to Reperfusion and Treatment Effect for Acute Ischemic Stroke: A Randomized Clinical Trial (vol 73, pg 190, 2016)
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Brouwer, Patrick A., van der Lugt, Aad, Emmer, Bart J., Majoie, Charles B. L. M., Beenen, Ludo F. M., Sprengers, Marieke E. S., van den Berg, Rene, Berkhemer, Olvert A., Amsterdam Neuroscience - Neurovascular Disorders, Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, Graduate School, and Other Research
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- 2016
150. Endovascular thrombectomy after large-vessel ischaemic stroke : a meta-analysis of individual patient data from five randomised trials
- Author
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Goyal, Mayank, Menon, Bijoy, van Zwam, Wim, Dippel, Diederik, Roy, Peter, Demchuk, Andrew, Dávalos, Antoni, Majoie, Charles, van der Lugt, Aad, de Miquel, Maria, Donnan, Geoffrey, Roos, Yvo, Bonafe, Alain, Jahan, Reza, Diener, Hans-Christoph, van den Berg, Lucie, Levy, Elad, Berkhemer, Olvert, Pereira, Vitor, Rempel, Jeremy, Millán, Mònica, Roy, Stephen, Roy, Daniel, Thornton, John, Román, Luis San, Ribo, Marc, Beumer, Debbie, Stouch, Bruce, Brown, Scott, Campbell, Bruce, van Oostenbrugge, Robert, Saver, Jeffrey, Hill, Michael, Jovin, Tudor, Mitchell, Peter, Davis, Stephen, Neurology, Radiology & Nuclear Medicine, RS: CARIM - R3.11 - Imaging, Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), MUMC+: MA AIOS Neurologie (9), RS: CARIM - R3.03 - Cerebral small vessel disease, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), ANS - Neurovascular Disorders, Radiology and Nuclear Medicine, ACS - Amsterdam Cardiovascular Sciences, Graduate School, Hotchkiss Brain Institute, Erasmus University Medical Center [Rotterdam] (Erasmus MC), University of Calgary, Hospital Universitario Germans Trias I Pujol, University of Amsterdam [Amsterdam] (UvA), Departments of Radiology and of Epidemiology [Rotterdam], University of Melbourne, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of California [Los Angeles] (UCLA), University of California, Department of Neurology, University Hospital Essen, University of Minho [Braga], University College London Hospitals (UCLH), Universitat de Barcelona, Universitat de Barcelona (UB), The Royal Melbourne Hospital, Department of Neurology [Maastricht, The Netherlands], Maastricht University Medical Centre - MUMC [Maastricht, The Netherlands], University of Pittsburgh (PITT), and Pennsylvania Commonwealth System of Higher Education (PCSHE)
- Subjects
Male ,medicine.medical_specialty ,Population ,Medizin ,030204 cardiovascular system & hematology ,Article ,Brain Ischemia ,03 medical and health sciences ,0302 clinical medicine ,Fibrinolytic Agents ,Modified Rankin Scale ,Internal medicine ,medicine.artery ,Occlusion ,medicine ,Odds Ratio ,Humans ,education ,Stroke ,Aged ,Randomized Controlled Trials as Topic ,Thrombectomy ,Aged, 80 and over ,education.field_of_study ,business.industry ,Endovascular Procedures ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,3. Good health ,Surgery ,Treatment Outcome ,Tissue Plasminogen Activator ,Middle cerebral artery ,Cardiology ,Female ,Internal carotid artery ,business ,Intracranial Hemorrhages ,030217 neurology & neurosurgery ,Fibrinolytic agent ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; BACKGROUND:In 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. In this meta-analysis we, the trial investigators, aimed to pool individual patient data from these trials to address remaining questions about whether the therapy is efficacious across the diverse populations included.METHODS:We formed the HERMES collaboration to pool patient-level data from five trials (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND IA) done between December, 2010, and December, 2014. In these trials, patients with acute ischaemic stroke caused by occlusion of the proximal anterior artery circulation were randomly assigned to receive either endovascular thrombectomy within 12 h of symptom onset or standard care (control), with a primary outcome of reduced disability on the modified Rankin Scale (mRS) at 90 days. By direct access to the study databases, we extracted individual patient data that we used to assess the primary outcome of reduced disability on mRS at 90 days in the pooled population and examine heterogeneity of this treatment effect across prespecified subgroups. To account for between-trial variance we used mixed-effects modelling with random effects for parameters of interest. We then used mixed-effects ordinal logistic regression models to calculate common odds ratios (cOR) for the primary outcome in the whole population (shift analysis) and in subgroups after adjustment for age, sex, baseline stroke severity (National Institutes of Health Stroke Scale score), site of occlusion (internal carotid artery vs M1 segment of middle cerebral artery vs M2 segment of middle cerebral artery), intravenous alteplase (yes vs no), baseline Alberta Stroke Program Early CT score, and time from stroke onset to randomisation.FINDINGS:We analysed individual data for 1287 patients (634 assigned to endovascular thrombectomy, 653 assigned to control). Endovascular thrombectomy led to significantly reduced disability at 90 days compared with control (adjusted cOR 2.49, 95% CI 1.76-3.53; p
- Published
- 2016
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