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3,976 results on '"Becker, Richard"'

104. Biomarker Concentrations and Their Temporal Changes in Patients With Myocardial Infarction and Nonobstructive Compared With Obstructive Coronary Arteries : Results From the PLATO Trial

Author

Hjort, Marcus, Eggers, Kai M., Ghukasyan Lakic, Tatevik, Lindbäck, Johan, Budaj, Andrzej, Cornel, Jan H., Giannitsis, Evangelos, Katus, Hugo A., Siegbahn, Agneta, Storey, Robert F., Becker, Richard C., Wallentin, Lars, Lindahl, Bertil, Hjort, Marcus, Eggers, Kai M., Ghukasyan Lakic, Tatevik, Lindbäck, Johan, Budaj, Andrzej, Cornel, Jan H., Giannitsis, Evangelos, Katus, Hugo A., Siegbahn, Agneta, Storey, Robert F., Becker, Richard C., Wallentin, Lars, and Lindahl, Bertil

Abstract

Background: The pathobiology of myocardial infarction (MI) with nonobstructive coronary arteries (MINOCA) is often uncertain. Investigating biomarker concentrations and their changes may offer novel pathophysiological insights. Methods and Results: In this post hoc study of the PLATO (Platelet Inhibition and Patient Outcomes) trial, concentrations of hs‐cTnT (high‐sensitivity cardiac troponin T), NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), hs‐CRP (high‐sensitivity C‐reactive protein), and GDF‐15 (growth differentiation factor 15) were measured in patients with MINOCA at baseline (n=554) and at 1‐month follow‐up (n=107). For comparisons, biomarkers were also measured in patients with MI with obstructive (stenosis ≥50%) coronary artery disease (baseline: n=11 106; follow‐up: n=2755]). Adjusted linear regression models were used to compare concentrations and their short‐ and long‐term changes. The adjusted geometric mean ratios (GMRs) in patients with MINOCA (median age, 61 years; 50.4% women) indicated lower hs‐cTnT (GMR, 0.77 [95% CI, 0.68–0.88]) but higher hs‐CRP (GMR, 1.21 [95% CI, 1.08–1.37]) and GDF‐15 concentrations (GMR, 1.06 [95% CI, 1.02–1.11]) at baseline compared with patients with MI with obstructive coronary artery disease, whereas NT‐proBNP concentrations were similar. Temporal decreases in hs‐cTnT, NT‐proBNP, and hs‐CRP concentrations until 1‐month follow‐up were more pronounced in patients with MINOCA. At follow‐up, patients with MINOCA had lower concentrations of hs‐cTnT (GMR, 0.71 [95% CI, 0.60–0.84]), NT‐proBNP (GMR, 0.45 [95% CI, 0.36–0.56]), and hs‐CRP (GMR, 0.68 [95% CI, 0.53–0.86]). One‐month GDF‐15 concentrations were similar between both groups with MI. Conclusions: Biomarker concentrations suggest greater initial inflammatory activity, similar degree of myocardial dysfunction, and less pronounced myocardial injury during the acute phase of MINOCA compared with MI with obstructive coronary artery disease but also faster myocardial r, Title in dissertation list of papers: Biomarker concentrations and their temporal changes in myocardial infarction patients with non-obstructive compared to obstructive coronary arteries: results from the PLATelet inhibition and patient Outcomes (PLATO) trial

Published
2023
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105. Vascular endothelial growth factor-D plasma levels and VEGFD genetic variants are independently associated with outcomes in patients with cardiovascular disease

Author

Davidsson, Pia, Eketjall, Susanna, Eriksson, Niclas, Walentinsson, Anna, Becker, Richard C., Cavallin, Anders, Bogstedt, Anna, Collén, Anna, Held, Claes, James, Stefan, Siegbahn, Agneta, Stewart, Ralph, Storey, Robert S., White, Harvey, Wallentin, Lars, Davidsson, Pia, Eketjall, Susanna, Eriksson, Niclas, Walentinsson, Anna, Becker, Richard C., Cavallin, Anders, Bogstedt, Anna, Collén, Anna, Held, Claes, James, Stefan, Siegbahn, Agneta, Stewart, Ralph, Storey, Robert S., White, Harvey, and Wallentin, Lars

Abstract

Aims The vascular endothelial growth factor (VEGF) family is involved in pathophysiological mechanisms underlying cardiovascular (CV) diseases. The aim of this study was to investigate the associations between circulating VEGF ligands and/or soluble receptors and CV outcome in patients with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS). Methods and results Levels of VEGF biomarkers, including bFGF, Flt-1, KDR (VEGFR2), PlGF, Tie-2, VEGF-A, VEGF-C, and VEGF-D, were measured in the PLATO ACS cohort (n = 2091, discovery cohort). Subsequently, VEGF-D was also measured in the STABILITY CCS cohort (n = 4015, confirmation cohort) to verify associations with CV outcomes. Associations between plasma VEGF-D and outcomes were analysed by multiple Cox regression models with hazard ratios (HR [95% CI]) comparing the upper vs. the lower quartile of VEGF-D. Genome-wide association study (GWAS) of VEGF-D in PLATO identified SNPs that were used as genetic instruments in Mendelian randomization (MR) meta-analyses vs. clinical endpoints. GWAS and MR were performed in patients with ACS from PLATO (n = 10 013) and FRISC-II (n = 2952), and with CCS from the STABILITY trial (n = 10 786). VEGF-D, KDR, Flt-1, and PlGF showed significant association with CV outcomes. VEGF-D was most strongly associated with CV death (P = 3.73e-05, HR 1.892 [1.419, 2.522]). Genome-wide significant associations with VEGF-D levels were identified at the VEGFD locus on chromosome Xp22. MR analyses of the combined top ranked SNPs (GWAS P-values; rs192812042, P = 5.82e-20; rs234500, P = 1.97e-14) demonstrated a significant effect on CV mortality [P = 0.0257, HR 1.81 (1.07, 3.04) per increase of one unit in log VEGF-D]. Conclusion This is the first large-scale cohort study to demonstrate that both VEGF-D plasma levels and VEGFD genetic variants are independently associated with CV outcomes in patients with ACS and CCS. Measurements of VEGF-D levels and/or VEGFD genetic variants may provide incre

Published
2023
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108. North American Thrombosis Forum, AF Action Initiative Consensus Document

Author

Ruff, Christian T., Ansell, Jack E., Becker, Richard C., Benjamin, Emelia J., Deicicchi, David J., Mark Estes, N.A., Ezekowitz, Michael D., Fanikos, John, Fareed, Jawed, Garcia, David, Giugliano, Robert P., Goldhaber, Samuel Z., Granger, Christopher, Healey, Jeff S., Hull, Russell, Hylek, Elaine M., Libby, Peter, Lopes, Renato D., Mahaffey, Kenneth W., Mega, Jessica, Piazza, Gregory, Sasahara, Arthur A., Sorond, Farzaneh A., Spyropoulos, Alex C., Walenga, Jeanine M., and Weitz, Jeffrey I.

Published
2016
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110. Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial

Author

Lincoff, A Michael, Mehran, Roxana, Povsic, Thomas J, Zelenkofske, Steven L, Huang, Zhen, Armstrong, Paul W, Steg, P Gabriel, Bode, Christoph, Cohen, Mauricio G, Buller, Christopher, Laanmets, Peep, Valgimigli, Marco, Marandi, Toomas, Fridrich, Viliam, Cantor, Warren J, Merkely, Bela, Lopez-Sendon, Jose, Cornel, Jan H, Kasprzak, Jaroslaw D, Aschermann, Michael, Guetta, Victor, Morais, Joao, Sinnaeve, Peter R, Huber, Kurt, Stables, Rod, Sellers, Mary Ann, Borgman, Marilyn, Glenn, Lauren, Levinson, Arnold I, Lopes, Renato D, Hasselblad, Vic, Becker, Richard C, and Alexander, John H

Published
2016
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120. More about Data

Author

Becker, Richard A., primary, Chambers, John M., additional, and Wilks, Allan R., additional

Published
2018
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121. How S Works

Author

Becker, Richard A., primary, Chambers, John M., additional, and Wilks, Allan R., additional

Published
2018
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127. Abstract 94: Randomized, Double-blind, Placebo-controlled Phase 1 Study Of Vwf-binding Aptamer, Bb-031: Safety, Tolerability, Pharmacokinetic And Pharmacodynamic Activity In Healthy Volunteers

Author

Nimjee, Shahid M, primary, Wheeler, Debra, additional, Nelson, Stacy, additional, Shea, Richard J, additional, Sullivan, Taegen, additional, Mayer, Christina, additional, Pavliv, Leo, additional, Layzer, Juliana M, additional, Lickliter, Jason, additional, Sullenger, Bruce, additional, Campbell, Bruce, additional, and Becker, Richard C, additional

Published
2023
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137. Platelet-related biomarkers and their response to inhibition with aspirin and p2y12-receptor antagonists in patients with acute coronary syndrome

Author

Lowenstern, Angela, Storey, Robert F., Neely, Megan, Sun, Jie-Lena, Angiolillo, Dominick J., Cannon, Christopher P., Himmelmann, Anders, Huber, Kurt, James, Stefan K., Katus, Hugo A., Morais, Joao, Siegbahn, Agneta, Steg, Phillippe Gabriel, Wallentin, Lars, Becker, Richard C., and On behalf of the PLATO Investigators

Published
2017
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140. Identifying Important Places in People’s Lives from Cellular Network Data

Author

Isaacman, Sibren, Becker, Richard, Cáceres, Ramón, Kobourov, Stephen, Martonosi, Margaret, Rowland, James, Varshavsky, Alexander, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Lyons, Kent, editor, Hightower, Jeffrey, editor, and Huang, Elaine M., editor

Published
2011
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143. Association of Blood Pressure–Related Increase in Vascular Stiffness on Other Measures of Target Organ Damage in Youth

Author

Haley, Jessica E., primary, Woodly, Shalayna A., additional, Daniels, Stephen R., additional, Falkner, Bonita, additional, Ferguson, Michael A., additional, Flynn, Joseph T., additional, Hanevold, Coral D., additional, Hooper, Stephen R., additional, Ingelfinger, Julie R., additional, Khoury, Philip R., additional, Lande, Marc B., additional, Martin, Lisa J., additional, Meyers, Kevin E., additional, Mitsnefes, Mark, additional, Becker, Richard C., additional, Rosner, Bernard A., additional, Samuels, Joshua, additional, Tran, Andrew H., additional, and Urbina, Elaine M., additional

Published
2022
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