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101. Accuracy of Deep Learning Echocardiographic View Classification in Patients with Congenital or Structural Heart Disease: Importance of Specific Datasets

Author

Wegner, Felix K., primary, Benesch Vidal, Maria L., additional, Niehues, Philipp, additional, Willy, Kevin, additional, Radke, Robert M., additional, Garthe, Philipp D., additional, Eckardt, Lars, additional, Baumgartner, Helmut, additional, Diller, Gerhard-Paul, additional, and Orwat, Stefan, additional

Published
2022
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103. Study design and rationale of the pAtients pResenTing with cOngenital heaRt dIseAse Register (ARTORIA‐R)

Author

Sinning, Christoph, Zengin, Elvin, Diller, Gerhard-Paul, Onorati, Francesco, Castel, María-Angeles, Petit, Thibault, Chen, Yih-Sharng, Lo Rito, Mauro, Chiarello, Carmelina, Guillemain, Romain, Coniat, Karine Nubret-Le, Magnussen, Christina, Knappe, Dorit, Becher, Peter Moritz, Schrage, Benedikt, Smits, Jacqueline M., Metzner, Andreas, Knosalla, Christoph, Schoenrath, Felix, Miera, Oliver, Cho, Mi-Young, Bernhardt, Alexander, Weimann, Jessica, Goßling, Alina, Terzi, Amedeo, Amodeo, Antonio, Alfieri, Sara, Angeli, Emanuela, Ragni, Luca, Napoleone, Carlo Pace, Gerosa, Gino, Pradegan, Nicola, Rodrigus, Inez, Dumfarth, Julia, de Pauw, Michel, François, Katrien, Van Caenegem, Olivier, Ancion, Arnaut, Van Cleemput, Johan, Miličić, Davor, Moza, Ajay, Schenker, Peter, Thul, Josef, Steinmetz, Michael, Warnecke, Gregor, Ius, Fabio, Freyt, Susanne, Avsar, Murat, Sandhaus, Tim, Haneya, Assad, Eifert, Sandra, Saeed, Diyar, Borger, Michael, Welp, Henryk, Ablonczy, László, Schmack, Bastian, Ruhparwar, Arjang, Naito, Shiho, Hua, Xiaoqin, Fluschnik, Nina, Nies, Moritz, Keil, Laura, Senftinger, Juliana, Ismaili, Djemail, Kany, Shinwan, Csengeri, Dora, Cardillo, Massimo, Oliveti, Alessandra, Faggian, Giuseppe, Dorent, Richard, Jasseron, Carine, Blanco, Alicia Pérez, Márquez, José Manuel Sobrino, López-Vilella, Raquel, García-Álvarez, Ana, López, María Luz Polo, Rocafort, Alvaro Gonzalez, Fernández, Óscar González, Prieto-Arevalo, Raquel, Zatarain-Nicolás, Eduardo, Blanchart, Katrien, Boignard, Aude, Battistella, Pascal, Guendouz, Soulef, Houyel, Lucile, Para, Marylou, Flecher, Erwan, Gay, Arnaud, Épailly, Éric, Dambrin, Camille, Lam, Kaitlyn, Ka-lai, Cally Ho, Cho, Yang Hyun, Choi, Jin-Oh, Kim, Jae-Joong, Coats, Louise, Crossland, David Steven, Mumford, Lisa, Hakmi, Samer, Sivathasan, Cumaraswamy, Fabritz, Larissa, Schubert, Stephan, Gummert, Jan, Hübler, Michael, Jacksch, Peter, Zuckermann, Andreas, Laufer, Günther, Baumgartner, Helmut, Giamberti, Alessandro, Reichenspurner, Hermann, and Kirchhof, Paulus

Subjects
Heart Defects, Congenital, Adult, Cardiac & Cardiovascular Systems, Heart Defects, Congenital / therapy, Waiting Lists, Study Designs, Medizin, Heart transplantation, Heart Defects, Congenital / complications, MANAGEMENT, Diseases of the circulatory (Cardiovascular) system, Humans, ESC GUIDELINES, Heart Failure / therapy, Adults with congenital heart disease, Arrhythmia, Heart failure, Heart transplantation, Lung transplantation, Ventricular assist device, Retrospective Studies, GENERAL-POPULATION, Heart Failure, OUTCOMES, Study Design, Science & Technology, TRANSPLANTATION, MORTALITY, Heart Failure / epidemiology, Heart Transplantation / adverse effects, ADULTS, ASSOCIATION, EUROPEAN-SOCIETY, Lung transplantation, Heart Failure / etiology, RC666-701, Cardiovascular System & Cardiology, Ventricular assist device, Heart Transplantation, Heart Defects, Congenital / epidemiology, Adults with congenital heart disease, Human medicine, Life Sciences & Biomedicine, Arrhythmia, TASK-FORCE
Abstract

ESC heart failure 8(6), 5542-5550 (2021). doi:10.1002/ehf2.13574, Published by Wiley, Chichester

Published
2021
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106. Right ventricular longitudinal strain for risk stratification in low-flow, low-gradient aortic stenosis with low ejection fraction

Author

Dahou, Abdellaziz, Clavel, Marie-Annick, Capoulade, Romain, Bartko, Philipp Emanuel, Magne, Julien, Mundigler, Gerald, Bergler-Klein, Jutta, Burwash, Ian, Mascherbauer, Julia, Ribeiro, Henrique B, OʼConnor, Kim, Baumgartner, Helmut, Sénéchal, Mario, Dumesnil, Jean G, Rosenhek, Raphael, Mathieu, Patrick, Larose, Eric, Rodés-Cabau, Josep, and Pibarot, Philippe

Published
2016
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111. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC)

Author

Roffi, Marco, Patrono, Carlo, Collet, Jean-Philippe, Mueller, Christian, Valgimigli, Marco, Andreotti, Felicita, Bax, Jeroen J., Borger, Michael A., Brotons, Carlos, Chew, Derek P., Gencer, Baris, Hasenfuss, Gerd, Kjeldsen, Keld, Lancellotti, Patrizio, Landmesser, Ulf, Mehilli, Julinda, Mukherjee, Debabrata, Storey, Robert F., Windecker, Stephan, Baumgartner, Helmut, Gaemperli, Oliver, Achenbach, Stephan, Agewall, Stefan, Badimon, Lina, Baigent, Colin, Bueno, Héctor, Bugiardini, Raffaele, Carerj, Scipione, Casselman, Filip, Cuisset, Thomas, Erol, Çetin, Fitzsimons, Donna, Halle, Martin, Hamm, Christian, Hildick-Smith, David, Huber, Kurt, Iliodromitis, Efstathios, James, Stefan, Lewis, Basil S., Lip, Gregory Y. H., Piepoli, Massimo F., Richter, Dimitrios, Rosemann, Thomas, Sechtem, Udo, Steg, Ph. Gabriel, Vrints, Christian, and Luis Zamorano, Jose

Published
2016
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113. The Coronavirus Disease 2019 pandemic among adult congenital heart disease patients: Findings of a one-year multicentric, international study

Author

Ruperti Repilado, Francisco Javier, Baumgartner, Helmut, Bouma, Berto, Bouchardy, Judith, Budts, Werner, Campens, Laurence, Chessa, Massimo, del Cerro Marin, Maria Jesús, Gabriel, Harald, Gallego, Pastora, García-Orta, Rocío, González, Elvira Ana, Jensen, Annette Schophuus, Ladouceur, Magalie, Lockhart, Christopher, Miranda-Barrio, Berta, Morissens, Marielle, Pasquet, Agnès, Soriano, Joaquin Rueda, van den Bosch, Annemien Elise, van der Zwaan, Heleen Berdina, Tobler, Daniel, Greutmann, Matthias, and Schwerzmann, Markus

Published
2021
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114. Aortic valve stenosis

Author

Baumgartner, Helmut, primary, Donal, Erwan, additional, Orwat, Stefan, additional, Schmermund, Axel, additional, Rosenhek, Raphael, additional, and Maintz, David, additional

Published
2015
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117. Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: Executive summary

Author

Silversides, Candice K., Marelli, Ariane, Beauchesne, Luc, Dore, Annie, Kiess, Marla, Salehian, Omid, Bradley, Timothy, Colman, Jack, Connelly, Michael, Harris, Louise, Khairy, Paul, Mital, Seema, Niwa, Koichiro, Oechslin, Erwin, Poirier, Nancy, Schwerzmann, Markus, Taylor, Dylan, Vonder Muhll, Isabelle, Baumgartner, Helmut, Benson, Lee, Celermajer, David, Greutmann, Matthias, Horlick, Eric, Landzberg, Mike, Meijboom, Folkert, Mulder, Barbara, Warnes, Carole, Webb, Gary, and Therrien, Judith

Published
2010
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118. Einführung und Weiterentwicklung eines fallbasierten EKG-Praktikums - der Mehrwert der praxisorientierten Lehre

Author

Shomanova, Zornitsa, Reinke, Florian, Ahrens, Helmut, Reinecke, Holger, Baumgartner, Helmut, Marschall, Bernhard, and Eckardt, Lars

Subjects
ddc: 610, Medicine and health
Abstract

Zielsetzung: Die Analyse und die Auswertung eines EKGs hat bei der Diagnostik von Patienten aller Fachrichtungen eine wesentliche Bedeutung. Deswegen ist es von allen Studierenden gewünscht, dass eine sichere Interpretation dieser Untersuchung erfolgt. Bis zum Wintersemester (WS) 2018/19 wurde [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2021
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121. Abstract 13261: Utility of a Novel Ensemble Based Deep Learning Network for the Automatic Detection of Pulmonary Hypertension and Right Ventricular Dilatation: A Study Based on Data From 783 Individuals From Two Tertiary Centres

Author

Benesch Vidal, Maria Luisa, primary, Kempny, Aleksander, additional, Li, Wei, additional, Dimopoulos, Konstantinos, additional, Wort, John, additional, Fischer, Alicia, additional, Orwat, Stefan, additional, Baumgartner, Helmut, additional, Gatzoulis, Michael A, additional, and Diller, Gerhard, additional

Published
2021
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123. AHA/ACC vs ESC Guidelines for Management of Adults With Congenital Heart Disease

Author

Egidy Assenza, Gabriele, primary, Krieger, Eric V., additional, Baumgartner, Helmut, additional, Cupido, Blanche, additional, Dimopoulos, Konstantinos, additional, Louis, Clauden, additional, Lubert, Adam M., additional, Stout, Karen K., additional, Valente, Anne Marie, additional, Zeppenfeld, Katja, additional, and Opotowsky, Alexander R., additional

Published
2021
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124. Frequency, Mortality, and Predictors of Adverse Outcomes for Endocarditis in Patients with Congenital Heart Disease: Results of a Nationwide Analysis including 2512 Endocarditis Cases

Author

Maser, Maarja, primary, Freisinger, Eva, additional, Bronstein, Leo, additional, Köppe, Jeanette, additional, Orwat, Stefan, additional, Kaleschke, Gerrit, additional, Baumgartner, Helmut, additional, Diller, Gerhard-Paul, additional, and Lammers, Astrid, additional

Published
2021
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125. Maternal and neonatal complications in women with congenital heart disease: a nationwide analysis

Author

Lammers, Astrid Elisabeth, primary, Diller, Gerhard-Paul, additional, Lober, Rieke, additional, Möllers, Mareike, additional, Schmidt, Renate, additional, Radke, Robert M, additional, De-Torres-Alba, Fernando, additional, Kaleschke, Gerrit, additional, Marschall, Ursula, additional, Bauer, Ulrike M, additional, Gerß, Joachim, additional, Enders, Dominic, additional, and Baumgartner, Helmut, additional

Published
2021
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127. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: The Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD).

Author

Rydén, Lars, Grant, Peter J., Anker, Stefan D., Berne, Christian, Cosentino, Francesco, Danchin, Nicolas, Deaton, Christi, Escaned, Javier, Hammes, Hans-Peter, Huikuri, Heikki, Marre, Michel, Marx, Nikolaus, Mellbin, Linda, Ostergren, Jan, Patrono, Carlo, Seferovic, Petar, Uva, Miguel Sousa, Taskinen, Marja-Riita, Tendera, Michal, Tuomilehto, Jaakko, Valensi, Paul, Zamorano, Jose Luis, Zamorano, Jose Luis, Achenbach, Stephan, Baumgartner, Helmut, Bax, Jeroen J., Bueno, Héctor, Dean, Veronica, Deaton, Christi, Erol, Çetin, Fagard, Robert, Ferrari, Roberto, Hasdai, David, Hoes, Arno W., Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, Lancellotti, Patrizio, Linhart, Ales, Nihoyannopoulos, Petros, Piepoli, Massimo F., Ponikowski, Piotr, Sirnes, Per Anton, Tamargo, Juan Luis, Tendera, Michal, Torbicki, Adam, Wijns, William, Windecker, Stephan, De Backer, Guy, Sirnes, Per Anton, Ezquerra, Eduardo Alegria, Avogaro, Angelo, Badimon, Lina, Baranova, Elena, Baumgartner, Helmut, Betteridge, John, Ceriello, Antonio, Fagard, Robert, Funck-Brentano, Christian, Gulba, Dietrich C., Hasdai, David, Hoes, Arno W., Kjekshus, John K., Knuuti, Juhani, Kolh, Philippe, Lev, Eli, Mueller, Christian, Neyses, Ludwig, Nilsson, Peter M., Perk, Joep, Ponikowski, Piotr, Reiner, Željko, Sattar, Naveed, Schächinger, Volker, Scheen, André, Schirmer, Henrik, Strömberg, Anna, Sudzhaeva, Svetlana, Tamargo, Juan Luis, Viigimaa, Margus, Vlachopoulos, Charalambos, and Xuereb, Robert G.

Published
2013
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128. 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: The Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA)

Author

Brignole, Michele, Auricchio, Angelo, Baron-Esquivias, Gonzalo, Bordachar, Pierre, Boriani, Giuseppe, Breithardt, Ole-A, Cleland, John, Deharo, Jean-Claude, Delgado, Victoria, Elliott, Perry M., Gorenek, Bulent, Israel, Carsten W., Leclercq, Christophe, Linde, Cecilia, Mont, Lluís, Padeletti, Luigi, Sutton, Richard, Vardas, Panos E., Zamorano, Jose Luis, Achenbach, Stephan, Baumgartner, Helmut, Bax, Jeroen J., Bueno, Héctor, Dean, Veronica, Deaton, Christi, Erol, Cetin, Fagard, Robert, Ferrari, Roberto, Hasdai, David, Hoes, Arno W., Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, Lancellotti, Patrizio, Linhart, Ales, Nihoyannopoulos, Petros, Piepoli, Massimo F., Ponikowski, Piotr, Sirnes, Per Anton, Tamargo, Juan Luis, Tendera, Michal, Torbicki, Adam, Wijns, William, Windecker, Stephan, Kirchhof, Paulus, Blomstrom-Lundqvist, Carina, Badano, Luigi P., Aliyev, Farid, Bänsch, Dietmar, Baumgartner, Helmut, Bsata, Walid, Buser, Peter, Charron, Philippe, Daubert, Jean-Claude, Dobreanu, Dan, Faerestrand, Svein, Hasdai, David, Hoes, Arno W., Le Heuzey, Jean-Yves, Mavrakis, Hercules, McDonagh, Theresa, Merino, Jose Luis, Nawar, Mostapha M., Nielsen, Jens Cosedis, Pieske, Burkert, Poposka, Lidija, Ruschitzka, Frank, Tendera, Michal, Van Gelder, Isabelle C., and Wilson, Carol M.

Published
2013
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131. framework of deep learning networks provides expert-level accuracy for the detection and prognostication of pulmonary arterial hypertension.

Author

Diller, Gerhard-Paul, Vidal, Maria Luisa Benesch, Kempny, Aleksander, Kubota, Kana, Li, Wei, Dimopoulos, Konstantinos, Arvanitaki, Alexandra, Lammers, Astrid E, Wort, Stephen J, Baumgartner, Helmut, Orwat, Stefan, and Gatzoulis, Michael A

Subjects
DEEP learning, STATISTICS, MULTIVARIATE analysis, TETRALOGY of Fallot, CONCEPTUAL structures, ATRIAL septal defects, ARTIFICIAL neural networks, PROPORTIONAL hazards models
Abstract

Aims To test the hypothesis that deep learning (DL) networks reliably detect pulmonary arterial hypertension (PAH) and provide prognostic information. Methods and results Consecutive patients with PAH, right ventricular (RV) dilation (without PAH), and normal controls were included. An ensemble of deep convolutional networks incorporating echocardiographic views and estimated RV systolic pressure (RVSP) was trained to detect (invasively confirmed) PAH. In addition, DL-networks were trained to segment cardiac chambers and extracted geometric information throughout the cardiac cycle. The ability of DL parameters to predict all-cause mortality was assessed using Cox-proportional hazard analyses. Overall, 450 PAH patients, 308 patients with RV dilatation (201 with tetralogy of Fallot and 107 with atrial septal defects) and 67 normal controls were included. The DL algorithm achieved an accuracy and sensitivity of detecting PAH on a per patient basis of 97.6 and 100%, respectively. On univariable analysis, automatically determined right atrial area, RV area, RV fractional area change, RV inflow diameter and left ventricular eccentricity index (P < 0.001 for all) were significantly related to mortality. On multivariable analysis DL-based RV fractional area change (P < 0.001) and right atrial area (P = 0.003) emerged as independent predictors of outcome. Statistically, DL parameters were non-inferior to measures obtained manually by expert echocardiographers in predicting prognosis. Conclusion The study highlights the utility of DL algorithms in detecting PAH on routine echocardiograms irrespective of RV dilatation. The algorithms outperform conventional echocardiographic evaluation and provide prognostic information at expert-level. Therefore, DL methods may allow for improved screening and optimized management of PAH. [ABSTRACT FROM AUTHOR]

Published
2022
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134. Guidelines on the management of valvular heart disease (version 2012): The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)

Author

Vahanian, Alec, Alfieri, Ottavio, Andreotti, Felicita, Antunes, Manuel J., Barón-Esquivias, Gonzalo, Baumgartner, Helmut, Borger, Michael Andrew, Carrel, Thierry P., De Bonis, Michele, Evangelista, Arturo, Falk, Volkmar, Iung, Bernard, Lancellotti, Patrizio, Pierard, Luc, Price, Susanna, Schäfers, Hans-Joachim, Schuler, Gerhard, Stepinska, Janina, Swedberg, Karl, Takkenberg, Johanna, Von Oppell, Ulrich Otto, Windecker, Stephan, Zamorano, Jose Luis, Zembala, Marian, Bax, Jeroen J., Baumgartner, Helmut, Ceconi, Claudio, Dean, Veronica, Deaton, Christi, Fagard, Robert, Funck-Brentano, Christian, Hasdai, David, Hoes, Arno, Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, McDonagh, Theresa, Moulin, Cyril, Popescu, Bogdan A., Reiner, Željko, Sechtem, Udo, Sirnes, Per Anton, Tendera, Michal, Torbicki, Adam, Vahanian, Alec, Windecker, Stephan, Popescu, Bogdan A., Von Segesser, Ludwig, Badano, Luigi P., Bunc, Matjaž, Claeys, Marc J., Drinkovic, Niksa, Filippatos, Gerasimos, Habib, Gilbert, Kappetein, A. Pieter, Kassab, Roland, Lip, Gregory Y.H., Moat, Neil, Nickenig, Georg, Otto, Catherine M., Pepper, John, Piazza, Nicolo, Pieper, Petronella G., Rosenhek, Raphael, Shuka, Naltin, Schwammenthal, Ehud, Schwitter, Juerg, Mas, Pilar Tornos, Trindade, Pedro T., and Walther, Thomas

Published
2012
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139. Lack of specialist care is associated with increased morbidity and mortality in adult congenital heart disease: a population-based study

Author

Diller, Gerhard-Paul, primary, Orwat, Stefan, additional, Lammers, Astrid Elisabeth, additional, Radke, Robert M, additional, De-Torres-Alba, Fernando, additional, Schmidt, Renate, additional, Marschall, Ursula, additional, Bauer, Ulrike M, additional, Enders, Dominic, additional, Bronstein, Leo, additional, Kaleschke, Gerrit, additional, and Baumgartner, Helmut, additional

Published
2021
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141. 2020 ESC Guidelines for the management of adult congenital heart disease The Task Force for the management of adult congenital heart disease of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Adult Congenital Heart Disease (ISACHD)

Author

Baumgartner, Helmut, De Backer, Julie, Babu-Narayan, Sonya, Budts, Werner, Chessa, Massimo, Diller, Gerhard-Paul, Lung, Bernard, Kluin, Jolanda, Lang, Irene M, Meijboom, Folkert, Moons, Philip, Mulder, Barbara JM, Oechslin, Erwin, Roos-Hesselink, Jolien W, Schwerzmann, Markus, Sondergaard, Lars, and Zeppenfeld, Katja

Subjects
disease, late complications, diagnosis, adult, catheter intervention, patient follow-up, recommendations, imaging, medical treatment, Guidelines, congenital cardiac surgery, congenital heart disease
Abstract

ispartof: EUROPEAN HEART JOURNAL vol:42 issue:6 pages:563-645 ispartof: location:England status: published

Published
2021

142. ESC Guidelines on the management of cardiovascular diseases during pregnancy: The Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC)

Author

Regitz-Zagrosek, Vera, Blomstrom Lundqvist, Carina, Borghi, Claudio, Cifkova, Renata, Ferreira, Rafael, Foidart, Jean-Michel, Gibbs, J. Simon R., Gohlke-Baerwolf, Christa, Gorenek, Bulent, Iung, Bernard, Kirby, Mike, Maas, Angela H. E. M., Morais, Joao, Nihoyannopoulos, Petros, Pieper, Petronella G., Presbitero, Patrizia, Roos-Hesselink, Jolien W., Schaufelberger, Maria, Seeland, Ute, Torracca, Lucia, Bax, Jeroen, Auricchio, Angelo, Baumgartner, Helmut, Ceconi, Claudio, Dean, Veronica, Deaton, Christi, Fagard, Robert, Funck-Brentano, Christian, Hasdai, David, Hoes, Arno, Knuuti, Juhani, Kolh, Philippe, McDonagh, Theresa, Moulin, Cyril, Poldermans, Don, Popescu, Bogdan A., Reiner, Zeljko, Sechtem, Udo, Sirnes, Per Anton, Torbicki, Adam, Vahanian, Alec, Windecker, Stephan, Baumgartner, Helmut, Deaton, Christi, Aguiar, Carlos, Al-Attar, Nawwar, Garcia, Angeles Alonso, Antoniou, Anna, Coman, Ioan, Elkayam, Uri, Gomez-Sanchez, Miguel Angel, Gotcheva, Nina, Hilfiker-Kleiner, Denise, Kiss, Robert Gabor, Kitsiou, Anastasia, Konings, Karen T. S., Lip, Gregory Y. H., Manolis, Athanasios, Mebaaza, Alexandre, Mintale, Iveta, Morice, Marie-Claude, Mulder, Barbara J., Pasquet, Agnès, Price, Susanna, Priori, Silvia G., Salvador, Maria J., Shotan, Avraham, Silversides, Candice K., Skouby, Sven O., Stein, Jörg-Ingolf, Tornos, Pilar, Vejlstrup, Niels, Walker, Fiona, and Warnes, Carole

Published
2011
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143. Clinical value of stress transaortic flow rate during dobutamine echocardiography in reduced left ventricular ejection fraction

Author

Vamvakidou, Anastasia, Annabi, Mohamed Salah, Pibarot, Philippe, Plonska-Gosciniak, Edyta, Almeida, Ana G., Guzzetti, Ezequiel, Dahou, Abdellaziz, Burwash, Ian G., Koschutnik, Matthias, Bartko, Philipp E., Bergler-Klein, Jutta, Mascherbauer, Julia, Orwat, Stefan, Baumgartner, Helmut, Cavalcante, João L., Pinto, Fausto J., Kukulski, Tomasz, Kasprzak, Jaroslaw D., Clavel, Marie-Annick, Flachskampf, Frank A., Senior, Roxy, Vamvakidou, Anastasia, Annabi, Mohamed Salah, Pibarot, Philippe, Plonska-Gosciniak, Edyta, Almeida, Ana G., Guzzetti, Ezequiel, Dahou, Abdellaziz, Burwash, Ian G., Koschutnik, Matthias, Bartko, Philipp E., Bergler-Klein, Jutta, Mascherbauer, Julia, Orwat, Stefan, Baumgartner, Helmut, Cavalcante, João L., Pinto, Fausto J., Kukulski, Tomasz, Kasprzak, Jaroslaw D., Clavel, Marie-Annick, Flachskampf, Frank A., and Senior, Roxy

Abstract

BACKGROUND: Low rest transaortic flow rate (FR) has been shown previously to predict mortality in low-gradient aortic stenosis. However limited prognostic data exists on stress FR during low-dose dobutamine stress echocardiography. We aimed to assess the value of stress FR for the detection of aortic valve stenosis (AS) severity and the prediction of mortality. METHODS: This is a multicenter cohort study of patients with reduced left ventricular ejection fraction and low-gradient aortic stenosis (aortic valve area <1 cm2 and mean gradient <40 mmHg) who underwent low-dose dobutamine stress echocardiography to identify the AS severity and presence of flow reserve. The outcome assessed was all-cause mortality. RESULTS: Of the 287 patients (mean age, 75±10 years; males, 71%; left ventricular ejection fraction, 31±10%) over a mean follow-up of 24±30 months there were 127 (44.3%) deaths and 147 (51.2%) patients underwent aortic valve intervention. Higher stress FR was independently associated with reduced risk of mortality (hazard ratio, 0.97 [95% CI, 0.94–0.99]; P=0.01) after adjusting for age, chronic kidney disease, heart failure symptoms, aortic valve intervention, and rest left ventricular ejection fraction. The minimum cutoff for prediction of mortality was stress FR 210 mL/s. Following adjustment to the same important clinical and echocardiographic parameters, among the three criteria of AS severity during stress, ie, the guideline definition of aortic valve area <1cm2 and aortic valve mean gradient ≥40 mm Hg, or aortic valve mean gradient ≥40 mm Hg, or the novel definition of aortic valve area <1 cm2 at stress FR ≥210 mL/s, only the latter was independently associated with mortality (hazard ratio, 1.72 [95% CI, 1.05–2.82]; P=0.03). Furthermore aortic valve area <1cm2 at stress FR ≥210 mL/s was the only severe aortic stenosis criterion that was associated with improved outcome following aortic valve intervention (P<0.001). Guideline-defined stroke volume flow reser

Published
2021

144. Clinical outcome of COVID-19 in patients with adult congenital heart disease.

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, Schwerzmann, Markus, Ruperti-Repilado, Francisco Javier, Baumgartner, Helmut, Bouma, Berto, Bouchardy, Judith, Budts, Werner, Campens, Laurence, Chessa, Massimo, Del Cerro Marin, Maria Jesús, Gabriel, Harald, Gallego, Pastora, Garcia-Orta, Rocio, Gonzalez, Ana Elvira, Jensen, Annette Schophuus, Ladouceur, Magalie, Miranda-Barrio, Berta, Morissens, Marielle, Pasquet, Agnès, Rueda, Joaquín, van den Bosch, Annemien E, van der Zwaan, Heleen Berdina, Tobler, Daniel, Greutmann, Matthias, EPOCH, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, Schwerzmann, Markus, Ruperti-Repilado, Francisco Javier, Baumgartner, Helmut, Bouma, Berto, Bouchardy, Judith, Budts, Werner, Campens, Laurence, Chessa, Massimo, Del Cerro Marin, Maria Jesús, Gabriel, Harald, Gallego, Pastora, Garcia-Orta, Rocio, Gonzalez, Ana Elvira, Jensen, Annette Schophuus, Ladouceur, Magalie, Miranda-Barrio, Berta, Morissens, Marielle, Pasquet, Agnès, Rueda, Joaquín, van den Bosch, Annemien E, van der Zwaan, Heleen Berdina, Tobler, Daniel, Greutmann, Matthias, and EPOCH

Abstract

AIMS: Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD. METHODS: Twenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome. RESULTS: Of 105 patients with a mean age of 38±13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), ≥2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m2 (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0). CONCLUSIONS: Among patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome.

Published
2021

145. Acquired comorbidities in adults with congenital heart disease: an analysis of the German National Register for congenital heart defects

Author

Maurer, Susanne J., Bauer, Ulrike M. M., Baumgartner, Helmut, Uebing, Anselm Sebastian, Walther, Claudia, Tutarel, Oktay, Maurer, Susanne J., Bauer, Ulrike M. M., Baumgartner, Helmut, Uebing, Anselm Sebastian, Walther, Claudia, and Tutarel, Oktay

Abstract

Background: As adults with congenital heart disease (ACHD) are getting older, acquired comorbidities play an important role in morbidity and mortality. Data regarding their prevalence in ACHD that are representative on a population level are not available. Methods: The German National Register for Congenital Heart Defects was screened for ACHD. Underlying congenital heart disease (CHD), patient demographics, previous interventional/surgical interventions, and comorbidities were retrieved. Patients <40 years of age were compared to those ≥40 years. Results: A total of 4673 patients (mean age 33.6 ± 10.7 years, female 47.7%) was included. At least one comorbidity was present in 2882 patients (61.7%) altogether, and in 56.8% of patients below vs. 77.7% of patients over 40 years of age (p < 0.001). Number of comorbidities was higher in patients ≥40 years (2.1 ± 2.1) than in patients <40 years (1.2 ± 1.5, p < 0.001). On multivariable regression analysis, age and CHD complexity were significantly associated with the presence and number of comorbidities. Conclusions: At least one acquired comorbidity is present in approximately two-thirds of ACHD. Age and complexity of the CHD are significantly associated with the presence of comorbidities. These findings highlight the importance of addressing comorbidities in ACHD care to achieve optimal long-term outcomes.

Published
2021

146. Clinical outcome of COVID-19 in patients with adult congenital heart disease

Author

Schwerzmann, Markus, Ruperti-Repilado, Francisco Javier, Baumgartner, Helmut, Bouma, Berto, Bouchardy, Judith, Budts, Werner, Campens, Laurence, Chessa, Massimo, Cerro Marín, María Jesús del, Gabriel, Harald, Gallego, Pastora, García-Orta, Rocío, González, Ana Elvira, Jensen, Annette Schophuus, Ladouceur, Magalie, Miranda-Barrio, Berta, Morissens, Marielle, Pasquet, Agnes, Rueda, Joaquín, van den Bosch, Annemien E., van der Zwaan, Heleen Berdina, Tobler, Daniel, Greutmann, Matthias, Schwerzmann, Markus, Ruperti-Repilado, Francisco Javier, Baumgartner, Helmut, Bouma, Berto, Bouchardy, Judith, Budts, Werner, Campens, Laurence, Chessa, Massimo, Cerro Marín, María Jesús del, Gabriel, Harald, Gallego, Pastora, García-Orta, Rocío, González, Ana Elvira, Jensen, Annette Schophuus, Ladouceur, Magalie, Miranda-Barrio, Berta, Morissens, Marielle, Pasquet, Agnes, Rueda, Joaquín, van den Bosch, Annemien E., van der Zwaan, Heleen Berdina, Tobler, Daniel, and Greutmann, Matthias

Abstract

[Aims] Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD., [Methods] Twenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome., [Results] Of 105 patients with a mean age of 38±13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), ≥2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m2 (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0)., [Conclusions] Among patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome.

Published
2021

147. Imaging the adult with simple shunt lesions:Position paper from the EACVI and the ESC WG on ACHD. Endorsed by AEPC (Association for European Paediatric and Congenital Cardiology)

Author

Budts, Werner, Miller, Owen, Babu-Narayan, Sonya V., Li, Wei, Valsangiacomo Buechel, Emanuela, Frigiola, Alessandra, Van Den Bosch, Annemien, Bonello, Beatrice, Mertens, Luc, Hussain, Tarique, Parish, Victoria, Habib, Gilbert, Edvardsen, Thor, Geva, Tal, Roos-Hesselink, Jolien W., Hanseus, Katarina, Dos Subira, Laura, Baumgartner, Helmut, Gatzoulis, Michael, Di Salvo, Giovanni, Budts, Werner, Miller, Owen, Babu-Narayan, Sonya V., Li, Wei, Valsangiacomo Buechel, Emanuela, Frigiola, Alessandra, Van Den Bosch, Annemien, Bonello, Beatrice, Mertens, Luc, Hussain, Tarique, Parish, Victoria, Habib, Gilbert, Edvardsen, Thor, Geva, Tal, Roos-Hesselink, Jolien W., Hanseus, Katarina, Dos Subira, Laura, Baumgartner, Helmut, Gatzoulis, Michael, and Di Salvo, Giovanni

Abstract

In 2018, the position paper 'Imaging the adult with congenital heart disease: a multimodality imaging approach' was published. The paper highlights, in the first part, the different imaging modalities applied in adult congenital heart disease patients. In the second part, these modalities are discussed more detailed for moderate to complex anatomical defects. Because of the length of the paper, simple lesions were not touched on. However, imaging modalities to use for simple shunt lesions are still poorly known. One is looking for structured recommendations on which they can rely when dealing with an (undiscovered) shunt lesion. This information is lacking for the initial diagnostic process, during repair and at follow-up. Therefore, this paper will focus on atrial septal defect, ventricular septal defect, and persistent arterial duct. Pre-, intra-, and post-procedural imaging techniques will be systematically discussed. This position paper will offer algorithms that might help at a glance. The document is prepared for general cardiologists, trainees, medical students, imagers/technicians to select the most appropriate imaging modality and to detect the requested information for each specific lesion. It might serve as reference to which researchers could refer when setting up a (imaging) study.

Published
2021

150. Clinical characteristics and outcomes with rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation but underlying native mitral and aortic valve disease participating in the ROCKET AF trial

Author

Breithardt, Günter, Baumgartner, Helmut, Berkowitz, Scott D., Hellkamp, Anne S., Piccini, Jonathan P., Stevens, Susanna R., Lokhnygina, Yuliya, Patel, Manesh R., Halperin, Jonathan L., Singer, Daniel E., Hankey, Graeme J., Hacke, Werner, Becker, Richard C., Nessel, Christopher C., Mahaffey, Kenneth W., Fox, Keith A. A., and Califf, Robert M.

Published
2014
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