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103. Perioperative and Long-Term Outcome for Intrahepatic Cholangiocarcinoma: Impact of Major Versus Minor Hepatectomy

Author

Zhang, Xu-Feng, Bagante, Fabio, Chakedis, Jeffery, Moris, Dimitrios, Beal, Eliza W., Weiss, Matthew, Popescu, Irinel, Marques, Hugo P., Aldrighetti, Luca, Maithel, Shishir K., Pulitano, Carlo, Bauer, Todd W., Shen, Feng, Poultsides, George A., Soubrane, Oliver, Martel, Guillaume, Groot Koerkamp, B., Guglielmi, Alfredo, Itaru, Endo, and Pawlik, Timothy M.

Published
2017
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105. Assessment of the Lymph Node Status in Patients Undergoing Liver Resection for Intrahepatic Cholangiocarcinoma: the New Eighth Edition AJCC Staging System

Author

Bagante, Fabio, Spolverato, Gaya, Weiss, Matthew, Alexandrescu, Sorin, Marques, Hugo P., Aldrighetti, Luca, Maithel, Shishir K., Pulitano, Carlo, Bauer, Todd W., Shen, Feng, Poultsides, George A., Soubrane, Oliver, Martel, Guillaume, Groot Koerkamp, B., Guglielmi, Alfredo, Itaru, Endo, and Pawlik, Timothy M.

Published
2017
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107. ASO Visual Abstract: Long-Term Recurrence-Free and Overall Survival Differ Based on Common, Proliferative, and Inflammatory Subtypes After Resection of Intrahepatic Cholangiocarcinoma

Author

Alaimo, Laura, primary, Moazzam, Zorays, additional, Endo, Yutaka, additional, Lima, Henrique A., additional, Ruzzenente, Andrea, additional, Guglielmi, Alfredo, additional, Aldrighetti, Luca, additional, Weiss, Matthew, additional, Bauer, Todd W., additional, Alexandrescu, Sorin, additional, Poultsides, George A., additional, Maithel, Shishir K., additional, Marques, Hugo P., additional, Martel, Guillaume, additional, Pulitano, Carlo, additional, Shen, Feng, additional, Cauchy, François, additional, Koerkamp, Bas Groot, additional, Endo, Itaru, additional, and Pawlik, Timothy M., additional

Published
2022
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108. Lymph Node Examination and Patterns of Nodal Metastasis Among Patients with Left- Versus Right-Sided Intrahepatic Cholangiocarcinoma After Major Curative-Intent Resection

Author

Zhang, Xu-Feng, primary, Xue, Feng, additional, Weiss, Matthew, additional, Popescu, Irinel, additional, Marques, Hugo P., additional, Aldrighetti, Luca, additional, Maithel, Shishir K., additional, Pulitano, Carlo, additional, Bauer, Todd W., additional, Shen, Feng, additional, Poultsides, George A., additional, Cauchy, François, additional, Martel, Guillaume, additional, Koerkamp, B. Groot, additional, Itaru, Endo, additional, Lv, Yi, additional, and Pawlik, Timothy M., additional

Published
2022
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109. Higher Tumor Burden Status Dictates the Impact of Surgical Margin Status on Overall Survival in Patients Undergoing Resection of Intrahepatic Cholangiocarcinoma

Author

Endo, Yutaka, primary, Sasaki, Kazunari, additional, Moazzam, Zorays, additional, Lima, Henrique A., additional, Alaimo, Laura, additional, Guglielmi, Alfredo, additional, Aldrighetti, Luca, additional, Weiss, Matthew, additional, Bauer, Todd W., additional, Alexandrescu, Sorin, additional, Poultsides, George A., additional, Kitago, Minoru, additional, Maithel, Shishir K., additional, Marques, Hugo P., additional, Martel, Guillaume, additional, Pulitano, Carlo, additional, Shen, Feng, additional, Cauchy, François, additional, Koerkamp, Bas Groot, additional, Endo, Itaru, additional, and Pawlik, Timothy M., additional

Published
2022
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110. Long-Term Recurrence-Free and Overall Survival Differ Based on Common, Proliferative, and Inflammatory Subtypes After Resection of Intrahepatic Cholangiocarcinoma

Author

Alaimo, Laura, primary, Moazzam, Zorays, additional, Endo, Yutaka, additional, Lima, Henrique A., additional, Ruzzenente, Andrea, additional, Guglielmi, Alfredo, additional, Aldrighetti, Luca, additional, Weiss, Matthew, additional, Bauer, Todd W., additional, Alexandrescu, Sorin, additional, Poultsides, George A., additional, Maithel, Shishir K., additional, Marques, Hugo P., additional, Martel, Guillaume, additional, Pulitano, Carlo, additional, Shen, Feng, additional, Cauchy, François, additional, Koerkamp, Bas Groot, additional, Endo, Itaru, additional, and Pawlik, Timothy M., additional

Published
2022
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113. A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreas cancer

Author

Brown, Brooke A., primary, Myers, Paul J., additional, Adair, Sara J., additional, Pitarresi, Jason R., additional, Sah-Teli, Shiv K., additional, Hart, William S., additional, Barbeau, Michelle, additional, Leong, Kelsey, additional, Seyler, Nicholas, additional, Kane, William, additional, Lee, Kyoung Eun, additional, Stelow, Edward, additional, Simon, M. Celeste, additional, Koivunen, Peppi, additional, Bauer, Todd W., additional, Stanger, Ben Z., additional, and Lazzara, Matthew J., additional

Published
2022
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114. ASO Visual Abstract: Application of Hazard Function to Investigate Recurrence of Intrahepatic Cholangiocarcinoma After Curative-Intent Liver Resection: A Novel Approach to Characterize Recurrence

Author

Alaimo, Laura, primary, Moazzam, Zorays, additional, Brown, Zachary J., additional, Endo, Yutaka, additional, Ruzzenente, Andrea, additional, Guglielmi, Alfredo, additional, Aldrighetti, Luca, additional, Weiss, Matthew, additional, Bauer, Todd W., additional, Alexandrescu, Sorin, additional, Poultsides, George A., additional, Maithel, Shishir K., additional, Marques, Hugo P., additional, Martel, Guillaume, additional, Pulitano, Carlo, additional, Shen, Feng, additional, Soubrane, Olivier, additional, Koerkamp, Bas Groot, additional, Endo, Itaru, additional, and Pawlik, Timothy M., additional

Published
2022
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118. Performance of prognostic scores and staging systems in predicting long‐term survival outcomes after surgery for intrahepatic cholangiocarcinoma

Author

Buettner, Stefan, Galjart, Boris, van Vugt, Jeroen L. A., Bagante, Fabio, Alexandrescu, Sorin, Marques, Hugo P., Lamelas, Jorge, Aldrighetti, Luca, Gamblin, T. Clark, Maithel, Shishir K., Pulitano, Carlo, Margonis, Georgios A., Weiss, Matthew, Bauer, Todd W., Shen, Feng, Poultsides, George A., Marsh, J. Wallis, IJzermans, Jan N. M., Groot Koerkamp, Bas, and Pawlik, Timothy M.

Published
2017
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124. Application of Hazard Function to Investigate Recurrence of Intrahepatic Cholangiocarcinoma After Curative-Intent Liver Resection: A Novel Approach to Characterize Recurrence

Author

Alaimo, Laura, primary, Moazzam, Zorays, additional, Brown, Zachary J., additional, Endo, Yutaka, additional, Ruzzenente, Andrea, additional, Guglielmi, Alfredo, additional, Aldrighetti, Luca, additional, Weiss, Matthew, additional, Bauer, Todd W., additional, Alexandrescu, Sorin, additional, Poultsides, George A., additional, Maithel, Shishir K., additional, Marques, Hugo P., additional, Martel, Guillaume, additional, Pulitano, Carlo, additional, Shen, Feng, additional, Soubrane, Olivier, additional, Koerkamp, Bas Groot, additional, Endo, Itaru, additional, and Pawlik, Timothy M., additional

Published
2022
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125. Comparison of Hepatic Arterial Infusion Pump Chemotherapy vs Resection for Patients With Multifocal Intrahepatic Cholangiocarcinoma

Author

Franssen, Stijn, primary, Soares, Kevin C., additional, Jolissaint, Joshua Samuel, additional, Tsilimigras, Diamantis I., additional, Buettner, Stefan, additional, Alexandrescu, Sorin, additional, Marques, Hugo, additional, Lamelas, Jorge, additional, Aldrighetti, Luca, additional, Gamblin, T. Clark, additional, Maithel, Shishir K., additional, Pulitano, Carlo, additional, Margonis, Georgios A., additional, Weiss, Matthew J., additional, Bauer, Todd W., additional, Shen, Feng, additional, Poultsides, George A., additional, Marsh, James Wallis, additional, Cercek, Andrea, additional, Kemeny, Nancy, additional, Kingham, T. Peter, additional, D’Angelica, Michael, additional, Pawlik, Timothy M., additional, Jarnagin, William R., additional, and Koerkamp, Bas Groot, additional

Published
2022
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126. ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer

Author

Ozturk, Harun, primary, Cingoz, Harun, additional, Tufan, Turan, additional, Yang, Jiekun, additional, Adair, Sara J., additional, Tummala, Krishna Seshu, additional, Kuscu, Cem, additional, Kinali, Meric, additional, Comertpay, Gamze, additional, Nagdas, Sarbajeet, additional, Goudreau, Bernadette J., additional, Luleyap, Husnu Umit, additional, Bingul, Yagmur, additional, Ware, Timothy B., additional, Hwang, William L., additional, Hsu, Ku-lung, additional, Kashatus, David F., additional, Ting, David T., additional, Chandel, Navdeep S., additional, Bardeesy, Nabeel, additional, Bauer, Todd W., additional, and Adli, Mazhar, additional

Published
2022
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129. Inhibition of the Growth of Patient-Derived Pancreatic Cancer Xenografts with the MEK Inhibitor Trametinib Is Augmented by Combined Treatment with the Epidermal Growth Factor Receptor/HER2 Inhibitor Lapatinib

Author

Walters, Dustin M., Lindberg, James M., Adair, Sara J., Newhook, Timothy E., Cowan, Catharine R., Stokes, Jayme B., Borgman, Cheryl A., Stelow, Edward B., Lowrey, Bryce T., Chopivsky, Maria E., Gilmer, Tona M., Parsons, John T., and Bauer, Todd W.

Published
2013
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131. Dynamic Prediction of Survival After Curative Resection of Intrahepatic Cholangiocarcinoma:A Landmarking-Based Analysis

Author

Spolverato, Gaya, Capelli, Giulia, Lorenzoni, Giulia, Gregori, Dario, He, Jin, Popescu, Irinel, Marques, Hugo P., Aldrighetti, Luca, Maithel, Shishir K., Pulitano, Carlo, Bauer, Todd W., Shen, Feng, Poultsides, George A., Soubrane, Oliver, Martel, Guillaume, Koerkamp, Bas Groot, Itaru, Endo, Lv, Yi, Pawlik, Timothy M., Spolverato, Gaya, Capelli, Giulia, Lorenzoni, Giulia, Gregori, Dario, He, Jin, Popescu, Irinel, Marques, Hugo P., Aldrighetti, Luca, Maithel, Shishir K., Pulitano, Carlo, Bauer, Todd W., Shen, Feng, Poultsides, George A., Soubrane, Oliver, Martel, Guillaume, Koerkamp, Bas Groot, Itaru, Endo, Lv, Yi, and Pawlik, Timothy M.

Abstract

Background The current study aimed to develop a dynamic prognostic model for patients undergoing curative-intent resection for intrahepatic cholangiocarcinoma (ICC) using landmark analysis. Methods Patients who underwent curative-intent surgery for ICC from 1999 to 2017 were selected from a multi-institutional international database. A landmark analysis to undertake dynamic overall survival (OS) prediction was performed. A multivariate Cox proportional hazard model was applied to measure the interaction of selected variables with time. The performance of the model was internally cross-validated via bootstrap resampling procedure. Discrimination was evaluated using the Harrell's Concordance Index. Accuracy was evaluated with calibration plots. Results Variables retained in the multivariable Cox regression OS model included age, tumor size, margin status, morphologic type, histologic grade, T and N category, and tumor recurrence. The effect of several variables on OS changed over time. Results were provided as a survival plot and the predicted probability of OS at the desired time in the future. For example, a 65-year-old patient with an intraductal, T1, grade 3 or 4 ICC measuring 3 cm who underwent an R0 resection had a calculated estimated 3-year OS of 76%. The OS estimate increased if the patient had already survived 1 year (79%). The discrimination ability of the final model was very good (C-index: 0.80). Conclusion The long-term outcome for patients undergoing curative-intent surgery for ICC should be adjusted based on follow-up time and intervening events. The model in this study showed excellent discriminative ability and performed well in the validation process.

Published
2022

133. The effect of preoperative chemotherapy treatment in surgically treated intrahepatic cholangiocarcinoma patients—A multi‐institutional analysis

Author

Buettner, Stefan, Koerkamp, Bas Groot, Ejaz, Aslam, Buisman, Florian E., Kim, Yuhree, Margonis, Georgios Antonios, Alexandrescu, Sorin, Marques, Hugo P., Lamelas, Jorge, Aldrighetti, Luca, Gamblin, T. Clark, Maithel, Shishir K., Pulitano, Carlo, Bauer, Todd W., Shen, Feng, Poultsides, George A., Marsh, J. Wallis, IJzermans, Jan N.M., and Pawlik, Timothy M.

Published
2017
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135. Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration

Author

Spolverato, Gaya, Kim, Yuhree, Alexandrescu, Sorin, Popescu, Irinel, Marques, Hugo P., Aldrighetti, Luca, Clark Gamblin, T., Miura, John, Maithel, Shishir K., Squires, Malcolm H., Pulitano, Carlo, Sandroussi, Charbel, Mentha, Gilles, Bauer, Todd W., Newhook, Timothy, Shen, Feng, Poultsides, George A., Wallis Marsh, J., and Pawlik, Timothy M.

Published
2015
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140. Prognostic impact of perineural invasion in intrahepatic cholangiocarcinoma: multicentre study

Author

Wei, Tao, primary, Zhang, Xu-Feng, additional, He, Jin, additional, Popescu, Irinel, additional, Marques, Hugo P., additional, Aldrighetti, Luca, additional, Maithel, Shishir K., additional, Pulitano, Carlo, additional, Bauer, Todd W., additional, Shen, Feng, additional, Poultsides, George A., additional, Soubrane, Oliver, additional, Martel, Guillaume, additional, Koerkamp, Bas Groot, additional, Itaru, Endo, additional, Lv, Yi, additional, and Pawlik, Timothy M., additional

Published
2022
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143. 619 DEVELOPMENT OF AN ARTIFICIAL INTELLIGENCE BASED MODEL TO PREDICT EARLY RECURRENCE OF NEUROENDOCRINE LIVER METASTASIS FOLLOWING RESECTION

Author

Altaf, Abdullah, Khan, Muhammad Muntazir M., Endo, Yutaka, Khalil, Mujtaba, Rashid, Zayed, Guglielmi, Alfredo, Aldrighetti, Luca, Bauer, Todd W., Marques, Hugo P., Martel, Guillaume, Lam, Vincent, Weiss, Matthew, Fields, Ryan C., Poultsides, George A., Maithel, Shishir K., Endo, Itaru, and Pawlik, Timothy M.

Published
2024
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145. Genomic Profiling of Intrahepatic Cholangiocarcinoma: Refining Prognosis and Identifying Therapeutic Targets

Author

Zhu, Andrew X., Borger, Darrell R., Kim, Yuhree, Cosgrove, David, Ejaz, Aslam, Alexandrescu, Sorin, Groeschl, Ryan Thomas, Deshpande, Vikram, Lindberg, James M., Ferrone, Cristina, Sempoux, Christine, Yau, Thomas, Poon, Ronnie, Popescu, Irinel, Bauer, Todd W., Gamblin, T. Clark, Gigot, Jean Francois, Anders, Robert A., and Pawlik, Timothy M.

Published
2014
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146. Open Versus Minimally Invasive Resection of Gastric GIST: A Multi-Institutional Analysis of Short- and Long-Term Outcomes

Author

Bischof, Danielle A., Kim, Yuhree, Dodson, Rebecca, Carolina Jimenez, M., Behman, Ramy, Cocieru, Andrei, Blazer, III, Dan G., Fisher, Sarah B., Squires, III, Malcolm H., Kooby, David A., Maithel, Shishir K., Groeschl, Ryan T., Clark Gamblin, T., Bauer, Todd W., Karanicolas, Paul J., Law, Calvin, Quereshy, Fayez A., and Pawlik, Timothy M.

Published
2014
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147. Tumor Size Predicts Vascular Invasion and Histologic Grade Among Patients Undergoing Resection of Intrahepatic Cholangiocarcinoma

Author

Spolverato, Gaya, Ejaz, Aslam, Kim, Yuhree, Sotiropoulos, Georgios C., Pau, Andreas, Alexandrescu, Sorin, Marques, Hugo, Pulitano, Carlo, Barroso, Eduardo, Clary, Bryan M., Aldrighetti, Luca, Bauer, Todd W., Walters, Dustin M., Groeschl, Ryan, Gamblin, T. Clark, Marsh, Wallis, Nguyen, Kevin T., Turley, Ryan, Popescu, Irinel, Hubert, Catherine, Meyer, Stephanie, Gigot, Jean-Francois, Mentha, Gilles, and Pawlik, Timothy M.

Published
2014
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149. Proposed modification of the eighth edition of the AJCC staging system for intrahepatic cholangiocarcinoma

Author

Zhang, Xu-Feng, primary, Xue, Feng, additional, He, Jin, additional, Alexandrescu, Sorin, additional, Marques, Hugo P., additional, Aldrighetti, Luca, additional, Maithel, Shishir K., additional, Pulitano, Carlo, additional, Bauer, Todd W., additional, Shen, Feng, additional, Poultsides, George A., additional, Soubrane, Oliver, additional, Martel, Guillaume, additional, Koerkamp, Bas G., additional, Itaru, Endo, additional, Lv, Yi, additional, and Pawlik, Timothy M., additional

Published
2021
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150. Launch of the PANC-PALS Consortium

Author

Javed, Ammar A, Hidalgo Salinas, Camila, Wolfgang, Christopher L, Besselink, Marc G, Ahmad, Syed A., Ahuja, Nita, Andel, Paul C.M., Asbun, Horacio J., Bauer, Todd W., Boggi, Ugo, Bonsing, Bert A., Büchler, Markus W., Butturini, Giovanni, Busch, Oliver R., Cobos, Stanley, Daamen, Lois A., Dameseviciute, Ryte, Datta, Jashodeep, Dervenis, Christos, Diener, Markus K., Dixon, Elijah, Donahue, Timothy R., Edil, Barish H., Ejaz, Aslam, Falconi, Massimo, Lavista Ferres, Juan M, Ferrone, Cristina R., Fong, Zhi V., Fusai, Giuseppe K., Garnier, Jonathan, Groot Koerkamp, Bas, Hansen, Carsten P., Habib, Joseph R., Hashimoto, Daisuke, He, Jin, Hingh, Ignace H.J.T., Inoue, Yosuke, Islam, Saleem, Jang, Jin-Young, Jiang, Kuirong, Katz, Matthew H., Kooby, David A., Lancaster, William P., Maker, Ajay V., Marchegiani, Giovanni, Marchetti, Alessio, Matsumoto, Ippei, McGinty, Patricia A., Molenaar, I. Quintus, Nagakawa, Yuichi, Page, Andrew J., Poultsides, George A., Qadan, Motaz, Rangelova, Elena, Reames, Bradley N., Reddy, Sushanth, Roberts, Keith J., Rocha, Flavio G., Rompen, Ingmar F., Sacks, Greg D., de Santibanes, Martin, Schwartz, Myron E., Seppänen, Hanna, Sham, Jonathan G., Shrikhande, Shailesh, Smith, Andrew, Sparrelid, Ernesto, Stoop, Thomas F., Tingstedt, Bobby, Truty, Mark J., Uhl, Waldemar, Weiss, Matthew J., Werner, Jens, Winter, Jordan M., Zafar, Syed Nabeel, Zeh, Herbert J., Zerbi, Alessandro, Zhao, Yupei, and Zyromski, Nicholas J.

Published
2024
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