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1,195 results on '"Bartmann P"'

101. Asphyxia Associated Metabolite Biomarker Investigation (AAMBI). Ergebnisse im Neugeborenenalter und mit 22-42 Monaten

Author

Franz, A, additional, Yapicioglu-Yildizdas, H, additional, Taskin, E, additional, Yaman, A, additional, Celik, Y, additional, Simsek, H, additional, Hamitoglu, S, additional, Aydinol, N, additional, Keles, E, additional, Keller, M, additional, Benders, M, additional, Groenendaal, F, additional, Anninck, K, additional, Hellström-Westas, L, additional, Saugstad, O, additional, Marlow, N, additional, Deigner, HP, additional, Kohl, M, additional, Meyer, R, additional, Plum, A, additional, Steins-Rang, C, additional, and Bartmann, P, additional

Published
2021
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102. Altered Gray Matter Cortical and Subcortical T1-Weighted/T2-Weighted Ratio in Premature-Born Adults

Author

Schmitz-Koep, Benita, Menegaux, Aurore, Gaser, Christian, Brandes, Elin, Schinz, David, Thalhammer, Melissa, Daamen, Marcel, Boecker, Henning, Zimmer, Claus, Priller, Josef, Wolke, Dieter, Bartmann, Peter, Sorg, Christian, and Hedderich, Dennis M.

Abstract

Microscopic studies in newborns and animal models indicate impaired myelination after premature birth, particularly for cortical myelination; however, it remains unclear whether such myelination impairments last into adulthood and, if so, are relevant for impaired cognitive performance. It has been suggested that the ratio of T1-weighted (T1w) and T2-weighted (T2w) magnetic resonance imaging signal intensity (T1w/T2w ratio) is a proxy for myelin content. We hypothesized altered gray matter (GM) T1w/T2w ratio in premature-born adults, which is associated with lower cognitive performance after premature birth.

Published
2023
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123. Aurora kinase inhibition and radiation therapy enhance the efficacy oftumour treating fields in recurrent glioblastoma treatment

Author

Thalmaier, T, Lachmann, D, Roosz, S, Bartmann, P, Jugel, W, Hagstotz, A, Temme, A, Michen, S, and Krex, D

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Tumor Treating Fields (TTFields) have been shown to be effective in prolonging progression-free and overall survival, thereby increasing the rate of two- and five-year survivors of patients with primary glioblastoma. However, the two-year survival rate is still below 50%, and the TTFields[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Published
2020
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128. Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions

Author

Katharina Schallmoser, Christina Bartmann, Eva Rohde, Simone Bork, Christian Guelly, Anna C. Obenauf, Andreas Reinisch, Patrick Horn, Anthony D. Ho, Dirk Strunk, and Wolfgang Wagner

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Background Research on mesenchymal stromal cells has created high expectations for a variety of therapeutic applications. Extensive propagation to yield enough mesenchymal stromal cells for therapy may result in replicative senescence and thus hamper long-term functionality in vivo. Highly variable proliferation rates of mesenchymal stromal cells in the course of long-term expansions under varying culture conditions may already indicate different propensity for cellular senescence. We hypothesized that senescence-associated regulated genes differ in mesenchymal stromal cells propagated under different culture conditions.Design and Methods Human bone marrow-derived mesenchymal stromal cells were cultured either by serial passaging or by a two-step protocol in three different growth conditions. Culture media were supplemented with either fetal bovine serum in varying concentrations or pooled human platelet lysate.Results All mesenchymal stromal cell preparations revealed significant gene expression changes upon long-term culture. Especially genes involved in cell differentiation, apoptosis and cell death were up-regulated, whereas genes involved in mitosis and proliferation were down-regulated. Furthermore, overlapping senescence-associated gene expression changes were found in all mesenchymal stromal cell preparations.Conclusions Long-term cell growth induced similar gene expression changes in mesenchymal stromal cells independently of isolation and expansion conditions. In advance of therapeutic application, this panel of genes might offer a feasible approach to assessing mesenchymal stromal cell quality with regard to the state of replicative senescence.

Published
2010
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131. Faecal egg count reduction tests and nemabiome analysis reveal high frequency of multi-resistant parasites on sheep farms in north-east Germany involving multiple strongyle parasite species.

Author

Krücken, Jürgen, Ehnert, Paula, Fiedler, Stefan, Horn, Fabian, Helm, Christina S., Ramünke, Sabrina, Bartmann, Tanja, Kahl, Alexandra, Neubert, Ann, Weiher, Wiebke, Daher, Ricarda, Terhalle, Werner, Klabunde-Negatsch, Alexandra, Steuber, Stephan, and von Samson-Himmelstjerna, Georg

Abstract

Anthelmintic resistance in sheep parasitic gastrointestinal nematodes is widespread and a severe health and economic issue but prevalence of resistance and involved parasite species are unknown in Germany. Here, the faecal egg count reduction test (FECRT) was performed on eight farms using fenbendazole, ivermectin and moxidectin and on four farms using only moxidectin. A questionnaire was used to obtain data on management practices to potentially identify risk factors for presence of resistance. All requirements of the recently revised WAAVP guideline for diagnosing anthelmintic resistance using the FECRT were applied. Nematode species composition in pre- and post-treatment samples was analysed with the nemabiome approach. Using the eggCounts statistic package, resistance against fenbendazole, ivermectin and moxidectin was found on 7/8, 8/8 and 8/12 farms, respectively. No formal risk factor analysis was conducted since resistance was present on most farms. Comparison with the bayescount R package results revealed substantial agreement between methods (Cohen's κ = 0.774). In contrast, interpretation of data comparing revised and original WAAVP guidelines resulted in moderate agreement (Cohen's κ = 0.444). The FECR for moxidectin was significantly higher than for ivermectin and fenbendazole. Nemabiome data identified 4 to 12 species in pre-treatment samples and treatments caused a small but significant decrease in species diversity (inverse Simpson index). Non-metric multidimensional scaling and k-means clustering were used to identify common patterns in pre- and post-treatment samples. However, post-treatment samples were scattered among the pre-treatment samples. Resistant parasite species differed between farms. In conclusion, the revised FECRT guideline allows robust detection of anthelmintic resistance. Resistance was widespread and involved multiple parasite species. Resistance against both drug classes on the same farm was common. Further studies including additional drugs (levamisole, monepantel, closantel) should combine sensitive FECRTs with nemabiome data to comprehensively characterise the anthelmintic susceptibility status of sheep nematodes in Germany. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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150. Aurora kinase inhibition to enhance tumour treating fields (TTFields) efficacy in glioblastoma treatment

Author

Roosz, S, Bartmann, P, Giladi, M, Palti, Y, Kinzel, A, Leidgens, V, Temme, A, and Krex, D

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Tumor Treating Fields (TTFields) have shown to be effective in the treatment of primary glioblastoma. However, the two-year survival rate is still below 50%. A promising approach to enhance the efficiency of TTFields is the use of drugs which extend metaphase-anaphase transition and [for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019
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