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104. Type of Atrial Fibrillation and Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement

Author

Shaul, Aviv A., Kornowski, Ran, Bental, Tamir, Vaknin‐Assa, Hana, Assali, Abid, Golovchiner, Gregory, Kadmon, Ehud, Codner, Pablo, Orvin, Katia, Strasberg, Boris, and Barsheshet, Alon

Subjects
Aged, 80 and over, Male, Original Articles, Aortic Valve Stenosis, Stroke, Transcatheter Aortic Valve Replacement, Postoperative Complications, Treatment Outcome, Risk Factors, Atrial Fibrillation, Humans, Female, Prospective Studies, Follow-Up Studies
Abstract

BACKGROUND: There are limited data available regarding the relationship between atrial fibrillation (AF) clinical type, oral anticoagulation (OAC) treatment, and clinical outcome after transcatheter aortic valve replacement (TAVR). The study was designed to evaluate this relationship. METHODS: We analyzed data from the Rabin Medical Center TAVR registry, including 319 consecutive patients who underwent TAVR from 2008 to 2014. Patients were divided into three groups based on their history of AF: sinus rhythm (SR), paroxysmal AF (PAF), or nonparoxysmal AF (NPAF). RESULTS: There were 211 (66%), 56 (18%), and 52 (16%) patients in the SR, PAF, and NPAF groups, respectively. The cumulative risk for stroke or death at 2 years was highest among patients with NPAF (38%), but similarly low in PAF (15%) and SR patients (16%, P < 0.001). By multivariate analysis, patients with NPAF demonstrated a significantly higher risk of stroke or death (HR = 2.76, 95% CI 1.63‐4.66, P < 0.001), as compared with SR. In contrast, patients with PAF had a similar risk of stroke or death compared with SR (HR = 0.80, P = 0.508). Patients with NPAF not treated with OAC demonstrated an 8.3‐fold (P < 0.001) increased risk of stroke or death, whereas patients with PAF not treated with OAC had a similar risk of stroke or death compared with the SR group (HR = 1.25, P = 0.569). CONCLUSION: History of NPAF, but not PAF, is associated with a significant increased risk of stroke or death compared with sinus rhythm in patients undergoing TAVR.

Published
2016

105. Time Dependence of Ventricular Tachyarrhythmias After Myocardial Infarction: A MADIT-CRT Substudy

Author

Özlü, Mehmet Fatih, Barsheshet, Alon, Moss, Arthur J., Goldenberg, Ilanc, Kutyifa, Valentinac, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Özlü, Mehmet Fatih

Subjects
myocardial infarction, cardiac resynchronization therapy, implantable cardioverter-defibrillators, ventricular tachycardia, ventricular fibrillation
Abstract

Objectives The purpose of this study was to assess the relationship between the time since a myocardial infarction (MI) and the risk of ventricular tachyarrhythmic events (VTEs) in patients with left ventricular dysfunction and mild symptoms of heart failure. Background Patients with left ventricular dysfunction after MI are at high risk for VTEs. Methods Ventricular tachycardia (VT), ventricular fibrillation (VF), or death as a function of time since MI was assessed in 693 patients enrolled in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy). Patients were categorized as those with a period of

Published
2016

106. Admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure

Author

Itzhaki Ben Zadok, Osnat, primary, Kornowski, Ran, additional, Goldenberg, Ilan, additional, Klempfner, Robert, additional, Toledano, Yoel, additional, Biton, Yitschak, additional, Fisman, Enrique Z., additional, Tenenbaum, Alexander, additional, Golovchiner, Gregory, additional, Kadmon, Ehud, additional, Omelchenko, Alexander, additional, Gal, Tuvia Ben, additional, and Barsheshet, Alon, additional

Published
2017
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109. Temporal trends in transcatheter aortic valve implantation, 2008-2014: patient characteristics, procedural issues, and clinical outcome

Author

Landes, Uri, primary, Barsheshet, Alon, additional, Finkelstein, Ariel, additional, Guetta, Victor, additional, Assali, Abid, additional, Halkin, Amir, additional, Vaknin-Assa, Hanna, additional, Segev, Amit, additional, Bental, Tamir, additional, Ben-Shoshan, Jeremy, additional, Barbash, Israel M., additional, and Kornowski, Ran, additional

Published
2016
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110. Effectiveness of cardiac resynchronization therapy by the frequency of revascularization procedures in ischemic cardiomyopathy patients

Author

Husaini, Mustafa, primary, Biton, Yitschak, additional, Stair, Brad, additional, Moss, Arthur J., additional, Biering-Sørensen, Tor, additional, Solomon, Scott, additional, McNitt, Scott, additional, Polonsky, Bronislava, additional, Zareba, Wojciech, additional, Barsheshet, Alon, additional, and Kutyifa, Valentina, additional

Published
2016
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113. IMPACT OF RENAL DYSFUNCTION ON TRANSCATHETER AORTIC VALVE REPLACEMENT OUTCOME IN A LARGE MULTICENTER COHORT

Author

Codner, Pablo, primary, Levi, Amos, additional, Gargiulo, Giussepe, additional, Praz, Fabien, additional, Hayashida, Kentaro, additional, Masalha, Amer, additional, Watanabe, Yusuke, additional, Myllotte, Darren, additional, Debry, Nicolas, additional, Barbanti, Marco, additional, Lefevre, Thierry, additional, Modine, Thomas, additional, Johan, Bosmans, additional, Windecker, Stephan, additional, Nickenig, Georg, additional, Barbash, Israel, additional, Sinning, Jan-Malte, additional, Barsheshet, Alon, additional, and Kornowski, Ran, additional

Published
2016
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115. Relative Wall Thickness and the Risk for Ventricular Tachyarrhythmias in Patients With Left Ventricular Dysfunction

Author

Biton, Yitschak, primary, Goldenberg, Ilan, additional, Kutyifa, Valentina, additional, Baman, Jayson R., additional, Solomon, Scott, additional, Moss, Arthur J., additional, Szepietowska, Barbara, additional, McNitt, Scott, additional, Polonsky, Bronislava, additional, Zareba, Wojciech, additional, and Barsheshet, Alon, additional

Published
2016
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118. Inverse Relationship of Blood Pressure to Long-Term Outcomes and Benefit of Cardiac Resynchronization Therapy in Patients With Mild Heart Failure

Author

Biton, Yitschak, primary, Moss, Arthur J., additional, Kutyifa, Valentina, additional, Mathias, Andrew, additional, Sherazi, Saadia, additional, Zareba, Wojciech, additional, McNitt, Scott, additional, Polonsky, Bronislava, additional, Barsheshet, Alon, additional, Brown, Mary W., additional, and Goldenberg, Ilan, additional

Published
2015
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119. Admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure.

Author

Ben Zadok, Osnat Itzhaki, Kornowski, Ran, Goldenberg, Ilan, Klempfner, Robert, Toledano, Yoel, Biton, Yitschak, Fisman, Enrique Z., Tenenbaum, Alexander, Golovchiner, Gregory, Kadmon, Ehud, Omelchenko, Alexander, Gal, Tuvia Ben, and Barsheshet, Alon

Subjects
BLOOD sugar, PEOPLE with diabetes, HEART failure, DISEASE exacerbation, RADIOGRAPHY, HEALTH
Abstract

Background: High admission blood glucose (ABG) level has been associated with a poor short-term outcome among non-diabetic patients with heart failure (HF). We aimed to investigate the association between ABG levels and long-term (10 years) mortality in patients with or without pre-existing diabetes mellitus (DM) admitted with HF. Methods: We analyzed data on 1811 patients with DM and 2182 patients without pre-existing DM who were hospitalized with HF during a prospective national survey. The relationship between ABG and 10-year mortality was assessed using the Cox proportional hazard model adjusting for multiple variables. ABG was analyzed both as a categorical (<110, 110-140, 140-200, and >200 mg/dL) and as a continuous variable. Results: At 10 years of follow-up the cumulative probability of mortality was 85 and 78% among patients with DM and patients with no pre-existing DM (p < 0.001), respectively. Among patients with no pre-existing DM, glucose levels of 110-140, 140-200 and ≥200 mg/dL were associated with 9% (p = 0.140), 16% (p = 0.031) and 53% (p < 0.001) increased mortality risk compared to ABG < 110 mg/dL. Each 18-mg/dL (1-mmol/L) increase in glucose level was associated with a 5% increased risk of mortality (p < 0.001) among patients with no-pre-existing DM. In contrast, among patients with DM, only those with glucose levels >200 mg/dL had an increased mortality risk (>200 mg/dL versus <110 mg/dL; HR = 1.20, p = 0.032). Conclusion: Among hospitalized HF patients with no pre-existing DM there is a linear relationship between ABG level and long-term mortality, whereas among patients with DM only ABG level >200 mg/dL is associated with increased mortality risk. [ABSTRACT FROM AUTHOR]

Published
2017
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121. Predictors of spontaneous reverse remodeling in mild heart failure patients with left ventricular dysfunction.

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, Brenyo, Andrew, Barsheshet, Alon, Kutyifa, Valentina, Ruwald, Anne-Christine, Rao, Mohan, Zareba, Wojciech, Pouleur, Anne-Catherine, Knappe, Dorit, Solomon, Scott D, McNitt, Scott, Huang, David T, Moss, Arthur J, Goldenberg, Ilan, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, Brenyo, Andrew, Barsheshet, Alon, Kutyifa, Valentina, Ruwald, Anne-Christine, Rao, Mohan, Zareba, Wojciech, Pouleur, Anne-Catherine, Knappe, Dorit, Solomon, Scott D, McNitt, Scott, Huang, David T, Moss, Arthur J, and Goldenberg, Ilan

Abstract

There are limited data regarding factors associated with spontaneous left ventricular reverse remodeling (S-LVRR) among mildly symptomatic heart failure (HF) patients and its prognostic implications on clinical outcomes.

Published
2014

122. Comparison of Age (<75 Years Versus ≥75 Years) to Risk of Ventricular Tachyarrhythmias and Implantable Cardioverter Defibrillator Shocks (from the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy)

Author

Aktas, Mehmet K., primary, Goldenberg, Ilan, additional, Moss, Arthur J., additional, Huang, David T., additional, Kutyifa, Valentina, additional, Wang, Paul J., additional, Brenyo, Andrew, additional, McNitt, Scott, additional, Zareba, Wojciech, additional, and Barsheshet, Alon, additional

Published
2014
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124. Predictors of Spontaneous Reverse Remodeling in Mild Heart Failure Patients With Left Ventricular Dysfunction

Author

Brenyo, Andrew, primary, Barsheshet, Alon, additional, Kutyifa, Valentina, additional, Ruwald, Anne-Christine, additional, Rao, Mohan, additional, Zareba, Wojciech, additional, Pouleur, Anne-Catherine, additional, Knappe, Dorit, additional, Solomon, Scott D., additional, McNitt, Scott, additional, Huang, David T., additional, Moss, Arthur J., additional, and Goldenberg, Ilan, additional

Published
2014
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125. Risk for Life-Threatening Cardiac Events in Patients With Genotype-Confirmed Long-QT Syndrome and Normal-Range Corrected QT Intervals

Author

Goldenberg, Ilan, Horr, Samuel, Moss, Arthur J., Lopes, Coeli M., Barsheshet, Alon, McNitt, Scott, Zareba, Wojciech, Andrews, Mark L., Robinson, Jennifer L., Locati, Emanuela H., Ackerman, Michael J., Benhorin, Jesaia, Kaufman, Elizabeth S., Napolitano, Carlo, Platonov, Pyotr, Priori, Silvia G., Qi, Ming, Schwartz, Peter J., Shimizu, Wataru, Towbin, Jeffrey A., Vincent, G. Michael, Wilde, Arthur A. M., Zhang, Li, Goldenberg, Ilan, Horr, Samuel, Moss, Arthur J., Lopes, Coeli M., Barsheshet, Alon, McNitt, Scott, Zareba, Wojciech, Andrews, Mark L., Robinson, Jennifer L., Locati, Emanuela H., Ackerman, Michael J., Benhorin, Jesaia, Kaufman, Elizabeth S., Napolitano, Carlo, Platonov, Pyotr, Priori, Silvia G., Qi, Ming, Schwartz, Peter J., Shimizu, Wataru, Towbin, Jeffrey A., Vincent, G. Michael, Wilde, Arthur A. M., and Zhang, Li

Abstract

Objectives This study was designed to assess the clinical course and to identify risk factors for life-threatening events in patients with long-QT syndrome (LQTS) with normal corrected QT (QTc) intervals. Background Current data regarding the outcome of patients with concealed LQTS are limited. Methods Clinical and genetic risk factors for aborted cardiac arrest (ACA) or sudden cardiac death (SCD) from birth through age 40 years were examined in 3,386 genotyped subjects from 7 multinational LQTS registries, categorized as LQTS with normal-range QTc (<= 440 ms [n = 469]), LQTS with prolonged QTc interval (>440 ms [ n = 1,392]), and unaffected family members (genotyped negative with <= 440 ms [ n = 1,525]). Results The cumulative probability of ACA or SCD in patients with LQTS with normal-range QTc intervals (4%) was significantly lower than in those with prolonged QTc intervals (15%) (p < 0.001) but higher than in unaffected family members (0.4%) (p < 0.001). Risk factors ACA or SCD in patients with normal-range QTc intervals included mutation characteristics (transmembrane-missense vs. nontransmembrane or nonmissense mutations: hazard ratio: 6.32; p = 0.006) and the LQTS genotypes (LQTS type 1: LQTS type 2, hazard ratio: 9.88; p = 0.03; LQTS type 3: LQTS type 2, hazard ratio: 8.04; p = 0.07), whereas clinical factors, including sex and QTc duration, were associated with a significant increase in the risk for ACA or SCD only in patients with prolonged QTc intervals (female age >13 years, hazard ratio: 1.90; p = 0.002; QTc duration, 8% risk increase per 10-ms increment; p = 0.002). Conclusions Genotype-confirmed patients with concealed LQTS make up about 25% of the at-risk LQTS population. Genetic data, including information regarding mutation characteristics and the LQTS genotype, identify increased risk for ACA or SCD in this overall lower risk LQTS subgroup. (J Am Coll Cardiol 2011;57:51-9) (C) 2011 by the American College of Cardiology Foundation

Published
2010

126. Response of right ventricular size to treatment with cardiac resynchronization therapy and the risk of ventricular tachyarrhythmias in MADIT-CRT

Author

Doyle, Colin L., primary, Huang, David T., additional, Moss, Arthur J., additional, Solomon, Scott D., additional, Campbell, Patricia, additional, McNitt, Scott, additional, Polonsky, Slava, additional, Barsheshet, Alon, additional, Aktas, Mehmet, additional, Tompkins, Christine, additional, Zareba, Wojciech, additional, and Goldenberg, Ilan, additional

Published
2013
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128. The Influence of Left Ventricular Ejection Fraction on the Effectiveness of Cardiac Resynchronization Therapy

Author

Kutyifa, Valentina, primary, Kloppe, Axel, additional, Zareba, Wojciech, additional, Solomon, Scott D., additional, McNitt, Scott, additional, Polonsky, Slava, additional, Barsheshet, Alon, additional, Merkely, Bela, additional, Lemke, Bernd, additional, Nagy, Vivien Klaudia, additional, Moss, Arthur J., additional, and Goldenberg, Ilan, additional

Published
2013
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130. Characteristics and outcomes of diabetic patients with an implantable cardioverter defibrillator in a real world setting: results from the Israeli ICD registry.

Author

Steiner, Hillel, Geist, Michael, Goldenberg, Ilan, Suleiman, Mahmoud, Glikson, Michael, Tenenbaum, Alexander, Swissa, Moshe, Fisman, Enrique Z., Golovchiner, Gregory, Strasberg, Boris, and Barsheshet, Alon

Subjects
IMPLANTABLE cardioverter-defibrillators, TREATMENT of diabetes, VENTRICULAR tachycardia, DIABETES, MORTALITY, CARDIOMYOPATHIES, ATRIAL fibrillation, COMORBIDITY, THERAPEUTICS
Abstract

Aims: There are limited data regarding the effect of diabetes mellitus (DM) on the risks of both appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy. The present study was designed to compare the outcome of appropriate and inappropriate ICD therapy in patients with or without DM. Methods and results: The risk of a first appropriate ICD therapy for ventricular tachyarrhythmias (including anti tachycardia pacing and shock) was compared between 764 DM and 1346 non-DM patients enrolled in the national Israeli ICD registry. We also compared the risks of inappropriate ICD therapy, and death or cardiac hospitalization between diabetic and non-diabetic patients. Diabetic patients were older, were more likely to have ischemic cardiomyopathy, lower ejection fraction, atrial fibrillation, and other co-morbidities. The 3-year cumulative incidence of appropriate ICD therapy was similar in the DM and non-DM groups (12 and 13%, respectively, p = 0.983). Multivariate analysis showed that DM did not affect the risk of appropriate ICD therapy (HR = 1.07, 95% CI 0.78-1.47, p = 0.694) or inappropriate therapy (HR = 0.72, 95% CI 0.42-1.23, p = 0.232). However, DM was associated with a 31% increased risk for death or cardiac hospitalization (p = 0.005). Results were similar in subgroup analyses including ICD and defibrillators with cardiac resynchronization therapy function recipients, primary or secondary prevention indication for an ICD. Conclusions: Despite a significant excess of cardiac hospitalizations and mortality in the diabetic population, there was no difference in the rate of ICD treatments, suggesting that the outcome difference is not related to arrhythmias. [ABSTRACT FROM AUTHOR]

Published
2016
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134. Reduction in Life-Threatening Ventricular Tachyarrhythmias in Statin-Treated Patients With Nonischemic Cardiomyopathy Enrolled in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy)

Author

Buber, Jonathan, primary, Goldenberg, Ilan, additional, Moss, Arthur J., additional, Wang, Paul J., additional, McNitt, Scott, additional, Hall, W. Jackson, additional, Eldar, Michael, additional, Barsheshet, Alon, additional, and Shechter, Michael, additional

Published
2012
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135. Response to Letter Regarding Article, “Predictors of Response to Cardiac Resynchronization Therapy in The Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (MADIT-CRT)”

Author

Goldenberg, Ilan, primary, Moss, Arthur J., additional, Hall, W. Jackson, additional, Barsheshet, Alon, additional, McNitt, Scott, additional, Zareba, Wojciech, additional, Klein, Helmut, additional, Foster, Elyse, additional, Goldberger, Jeffrey J., additional, Santucci, Peter, additional, Wilber, David, additional, Shinn, Timothy, additional, Solomon, Scott, additional, and Steinberg, Jonathan S., additional

Published
2012
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137. Mutations in Cytoplasmic Loops of the KCNQ1 Channel and the Risk of Life-Threatening Events

Author

Barsheshet, Alon, primary, Goldenberg, Ilan, additional, O-Uchi, Jin, additional, Moss, Arthur J., additional, Jons, Christian, additional, Shimizu, Wataru, additional, Wilde, Arthur A., additional, McNitt, Scott, additional, Peterson, Derick R., additional, Zareba, Wojciech, additional, Robinson, Jennifer L., additional, Ackerman, Michael J., additional, Cypress, Michael, additional, Gray, Daniel A., additional, Hofman, Nynke, additional, Kanters, Jorgen K., additional, Kaufman, Elizabeth S., additional, Platonov, Pyotr G., additional, Qi, Ming, additional, Towbin, Jeffrey A., additional, Vincent, G. Michael, additional, and Lopes, Coeli M., additional

Published
2012
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142. Predictors of Response to Cardiac Resynchronization Therapy in the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (MADIT-CRT)

Author

Goldenberg, Ilan, primary, Moss, Arthur J., additional, Hall, W. Jackson, additional, Foster, Elyse, additional, Goldberger, Jeffrey J., additional, Santucci, Peter, additional, Shinn, Timothy, additional, Solomon, Scott, additional, Steinberg, Jonathan S., additional, Wilber, David, additional, Barsheshet, Alon, additional, McNitt, Scott, additional, Zareba, Wojciech, additional, and Klein, Helmut, additional

Published
2011
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143. Cardiac Resynchronization Therapy Reduces Left Atrial Volume and the Risk of Atrial Tachyarrhythmias in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy)

Author

Brenyo, Andrew, primary, Link, Mark S., additional, Barsheshet, Alon, additional, Moss, Arthur J., additional, Zareba, Wojciech, additional, Wang, Paul J., additional, McNitt, Scott, additional, Huang, David, additional, Foster, Elyse, additional, Estes, Mark, additional, Solomon, Scott D., additional, and Goldenberg, Ilan, additional

Published
2011
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144. Risk of Syncope in Family Members Who Are Genotype-Negative for a Family-Associated Long-QT Syndrome Mutation

Author

Barsheshet, Alon, primary, Moss, Arthur J., additional, McNitt, Scott, additional, Polonsky, Slava, additional, Lopes, Coeli M., additional, Zareba, Wojciech, additional, Robinson, Jennifer L., additional, Ackerman, Michael J., additional, Benhorin, Jesaia, additional, Kaufman, Elizabeth S., additional, Towbin, Jeffrey A., additional, Vincent, G. Michael, additional, Qi, Ming, additional, and Goldenberg, Ilan, additional

Published
2011
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148. Reply

Author

Goldenberg, Ilan, primary, Liu, Judy F., additional, Barsheshet, Alon, additional, and Moss, Arthur J., additional

Published
2011
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149. Risk of Recurrent Cardiac Events After Onset of Menopause in Women With Congenital Long-QT Syndrome Types 1 and 2

Author

Buber, Jonathan, primary, Mathew, Jehu, additional, Moss, Arthur J., additional, Hall, W. Jackson, additional, Barsheshet, Alon, additional, McNitt, Scott, additional, Robinson, Jennifer L., additional, Zareba, Wojciech, additional, Ackerman, Michael J., additional, Kaufman, Elizabeth S., additional, Luria, David, additional, Eldar, Michael, additional, Towbin, Jeffrey A., additional, Vincent, Michael, additional, and Goldenberg, Ilan, additional

Published
2011
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150. Reverse Remodeling and the Risk of Ventricular Tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy)

Author

Barsheshet, Alon, primary, Wang, Paul J., additional, Moss, Arthur J., additional, Solomon, Scott D., additional, Al-Ahmad, Amin, additional, McNitt, Scott, additional, Foster, Elyse, additional, Huang, David T., additional, Klein, Helmut U., additional, Zareba, Wojciech, additional, Eldar, Michael, additional, and Goldenberg, Ilan, additional

Published
2011
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