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105. Outcomes of Scleral Buckle Removal: Experience from the Last Decade.

Author

Moisseiev, Elad, Fogel, Miri, Fabian, Ido Didi, Barak, Adiel, Moisseiev, Joseph, and Alhalel, Amir

Subjects
VISUAL acuity, RETROSPECTIVE studies, RETINAL detachment, TREATMENT of eye diseases, RETINAL diseases, RETINAL surgery
Abstract

Purpose: To evaluate the indications, outcomes, and complications of scleral buckle removal over the past decade and compare to previously published data. Methods: Forty nine eyes of 49 patients who underwent scleral buckle removal and had at least 6 months of follow-up were included in this retrospective study. Recorded parameters included demographic information, history of the retinal detachment, details of the scleral buckling surgery, indication for scleral buckle removal, time from scleral buckle placement to removal, culture results, length of follow up, visual acuity (VA) throughout the follow up, and the occurrence of any complications or need for additional surgery after scleral buckle removal. Results: The overall rate of scleral buckle removal over the last decade was 5.7% (85/1493). Indications included buckle extrusion (57.1%), infection (8.2%), both (26.5%) eyes, and strabismus and diplopia (8.2%). The median time from scleral buckle placement to removal was 35 months, but in 22.4% of cases the buckles were removed after less than 6 months, and in an additional 22.4% of cases after more than 10 years. The rate of recurrent retinal detachment after scleral buckle removal was 8.2%, with half of the cases occurring within 3 months of the removal. Conclusions: Removal of scleral buckles is associated with a 8.2% risk for redetachment. Redetachment can occur many years following the removal and long-term follow up in these patients is warranted. [ABSTRACT FROM AUTHOR]

Published
2017
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110. Inverse correlation between coronary and retinal blood flows in patients with normal coronary arteries and slow coronary blood flow

Author

Arbel, Yaron, primary, Sternfeld, Amir, additional, Barak, Adiel, additional, Burgansky-Eliash, Zvia, additional, Halkin, Amir, additional, Berliner, Shlomo, additional, Herz, Itzhak, additional, Keren, Gad, additional, Rubinstein, Ardon, additional, Banai, Shmuel, additional, and Finkelstein, Ariel, additional

Published
2014
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112. Reply

Author

Moisseiev, Elad, primary, Fabian, Ido Didi, additional, Moisseiev, Joseph, additional, and Barak, Adiel, additional

Published
2014
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114. High-resolution wide-field imaging of perfused capillaries without the use of contrast agent

Author

Nelson,Darin A, Burgansky-Eliash,Zvia, Barash,Hila, Loewenstein,Anat, Barak,Adiel, Bartov,Elisha, Rock,Tali, Grinvald,Amiram, Nelson,Darin A, Burgansky-Eliash,Zvia, Barash,Hila, Loewenstein,Anat, Barak,Adiel, Bartov,Elisha, Rock,Tali, and Grinvald,Amiram

Abstract

Darin A Nelson1, Zvia Burgansky-Eliash1,2, Hila Barash1, Anat Loewenstein3, Adiel Barak4, Elisha Bartov2, Tali Rock2, Amiram Grinvald51Optical Imaging Ltd, Rehovot, Israel; 2Department of Ophthalmology, Edith Wolfson Medical Center, Holon, Israel; 3Department of Ophthalmology, Tel Aviv Medical Center & Sackler Faculty of Medicine, Tel Aviv University, Israel; 4Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 5Department of Neurobiology, The Weizmann Institute of Science, Rehovot, IsraelPurpose: Assessment of capillary abnormalities facilitates early diagnosis, treatment, and follow-up of common retinal pathologies. Injected contrast agents like fluorescein are widely used to image retinal capillaries, but this highly effective procedure has a few disadvantages, such as untoward side effects, inconvenience of injection, and brevity of the time window for clear visualization. The retinal function imager (RFI) is a tool for monitoring retinal functions, such as blood velocity and oximetry, based on intrinsic signals. Here we describe the clinical use of hemoglobin in red blood cells (RBCs) as an intrinsic motion-contrast agent in the generation of detailed noninvasive capillary-perfusion maps (nCPMs).Patients and methods: Multiple series of nCPM images were acquired from 130 patients with diabetic retinopathy, vein occlusion, central serous retinopathy, age-related macular degeneration, or metabolic syndrome, as well as from 37 healthy subjects. After registration, pixel value distribution parameters were analyzed to locate RBC motion.Results: The RFI yielded nCPMs demonstrating microvascular morphology including capillaries in exquisite detail. Maps from the same subject were highly reproducible in repeated measurements, in as much detail and often better than that revealed by the very best fluorescein angiography. In patients, neovascularization and capillary nonperfusion areas were clearly observed. Foveal avascular zones (FAZ

Published
2011

115. Corrigendum

Author

Nelson,Darin A, Burgansky-Eliash,Zvia, Barash,Hila, Loewenstein,Anat, Barak,Adiel, Bartov,Elisha, Rock,Tali, Grinvald, Nelson,Darin A, Burgansky-Eliash,Zvia, Barash,Hila, Loewenstein,Anat, Barak,Adiel, Bartov,Elisha, Rock,Tali, and Grinvald

Abstract

Nelson DA, Burgansky-Eliash Z, Barash H, Loewenstein A, Barak A, Bartov E, Rock T, Grinvald AHigh-resolution widefield imaging of perfused capillaries without the use of contrast agentClinical Ophthalmology. 2011;5:1095-1106.The authors of this paper and their affiliations are as follows.Darin A Nelson1Amit Ruf1Jacob Oaknin1Zvia Burgansky-Eliash1,2Hila Barash1David Izhaky1Anat Loewenstein3Adiel Barak4Elisha Bartov2Tali Rock2Amiram Grinvald51Optical Imaging Ltd, Rehovot, Israel; 2Department of Ophthalmology, Edith Wolfson Medical Center, Holon, Israel; 3Department of Ophthalmology, Tel Aviv Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 4Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 5Department of Neurobiology, The Weizmann Institute of Science, Rehovot, IsraelOriginal Article

Published
2011

122. Blood-Flow Velocity in Glaucoma Patients Measured with the Retinal Function Imager.

Author

Burgansky–Eliash, Zvia, Bartov, Elisha, Barak, Adiel, Grinvald, Amiram, and Gaton, Dan

Subjects
GLAUCOMA, BLOOD circulation disorders, BLOOD circulation, RETINAL diseases, OPTIC nerve diseases, CHOROID diseases
Abstract

Purpose: Circulatory abnormalities in the retina, optic nerve and choroid have been detected by various technologies in glaucoma patients. However, there is no clear understanding of the role of blood flow in glaucoma. The purpose of this study was to compare retinal blood-flow velocities using the retinal function imager (RFI) between glaucoma and healthy subjects. Materials and Methods: Fifty-nine eyes of 46 patients with primary open-angle glaucoma (POAG), 51 eyes of 31 healthy individuals and 28 eyes of 23 patients with glaucomatous optic neuropathy (GON) but normal perimetry were recruited for this study. Three eyes of 2 patients in the glaucoma group and 2 eyes of 1 patient in the GON group had normal pressure at the time of diagnosis. Eighty-three percent of the glaucoma patients and 73% of the patients in the GON group were treated with anti-glaucoma medications. All patients were scanned by the RFI. Differences among groups were assessed by mixed linear models. Results: The average venous velocity in the GON group (3.8 mm/s) was significantly faster than in the glaucoma (3.3 mm/s, p = 0.03) and healthy (3.0 mm/s, p = 0.005) groups. The arterial velocity in the GON group was not different from any of the other study groups (4.7 mm/s). The arterial and venous velocity in the POAG eyes was not different than in the healthy eyes (arterial: 4.3 versus 4.2 mm/s, p = 0.7; venous: 3.3 versus 3.0 mm/s, p = 0.3). A subgroup of 13 glaucoma patients who had perimetric glaucoma in 1 eye and normal visual field (VF) in the fellow eye showed a trend of lower velocity in the glaucoma eyes. Conclusions: Changes in retinal blood-flow velocity were detected only in the pre-perimetric state, but not in perimetric glaucoma. These findings might represent early dysregulation in the retinal vasculature. [ABSTRACT FROM AUTHOR]

Published
2016
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144. Constitutive Expression of HIF-1α and HIF-2α in Bone Marrow Stromal Cells Differentially Promotes Their Proangiogenic Properties

Author

Ben-Shoshan, Jeremy, primary, Schwartz, Shulamit, additional, Luboshits, Galia, additional, Maysel-Auslender, Sofia, additional, Barzelay, Aya, additional, Polak-Charcon, Sylvie, additional, Tzahor, Eldad, additional, Barshack, Iris, additional, Barak, Adiel, additional, Levkovitch-Verbin, Hani, additional, Keren, Gad, additional, and George, Jacob, additional

Published
2008
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145. Drug Modification of Angiogenesis in a Rat Cornea Model

Author

Schwartz, Shulamit, primary, George, Jacob, additional, Ben-Shoshan, Jeremy, additional, Luboshits, Galia, additional, Avni, Isaac, additional, Levkovitch-Verbin, Hani, additional, Ziv, Hana, additional, Rosner, Mordechai, additional, and Barak, Adiel, additional

Published
2008
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147. Reassessment of pneumatic retinopexy for primary treatment of rhegmatogenous retinal detachment.

Author

Cohen, Eyal, Zerach, Amir, Mimouni, Michael, and Barak, Adiel

Subjects
RETINAL detachment, EYE examination, TREATMENT effectiveness, VISUAL acuity, OPHTHALMIC surgery, LASER surgery, PROLIFERATIVE vitreoretinopathy, THERAPEUTICS
Abstract

Background: Pneumatic retinopexy (PR) remains a popular technique for the treatment of rhegmatogenous retinal detachment (RRD). Objective: To evaluate the single operation and final success rate of PR for primary treatment of RRD and to determine factors associated with anatomical and visual outcomes. Methods: This retrospective case review study analyzed the data of patients who underwent PR for primary treatment of RRD. Patients with a follow-up period of <2 months were excluded. Single operation success was defined as successful retinal reattachment following a single PR throughout 2 months of follow-up. Results: Eighty-four eyes met the inclusion criteria. Single operation success was achieved in 50 eyes (59.5%), while 82 obtained anatomical success at the final follow-up visit (97.6%). An average of 0.702±1.095 additional retinal detachment operations was necessary to achieve final anatomical success in the entire cohort (n=84) and 1.4±1.3 in the single operation failure group (n=34). Both groups (single operation success vs failure) did not differ significantly in any of the preoperative variables. Multivariate analysis of pseudophakic patients (n=22) revealed that 52.65% of the variation in single operation outcome was explained by the number of clock-hours detached (partial R²=43.76%, P=0.001). The final best-corrected visual acuity was significantly better in the single operation success group (logarithm of minimum angle [logMAR] 0.229±0.249 vs logMAR 0.747±0.567, P,0.001). Conclusion: Careful patient selection is warranted before performing PR in RRD, particularly in pseudophakic patients with large detachments. Ultimately 60% of the cases will attach after the procedure with the rest requiring on average 1.4 additional procedures to achieve final anatomical success. [ABSTRACT FROM AUTHOR]

Published
2015
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