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410 results on '"Bacharova, Ljuba"'

143. Standards for the function of an academic 12-lead electrocardiographic core laboratory

Author

Anderson, Stanley T., primary, Pahlm, Olle, additional, Bacharova, Ljuba, additional, Barbagelata, Alejandro, additional, Chaitman, Bernard R., additional, Clemmensen, Peter, additional, Goodman, Shaun, additional, Hedén, Bo, additional, Klootwijk, Peter J., additional, Lauer, Michael, additional, MacFarlane, Peter W., additional, Rautaharju, Pentti, additional, Reddy, Shankara, additional, Selvester, Ronald H., additional, Sgarbossa, Elena B., additional, Underwood, Donald, additional, Warner, Robert A., additional, and Wagner, Galen S., additional

Published
2001
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145. Recommendations for the Monitoring of Short-term Health Effects of Air Pollution: Lessons from the APHEA Multi Centre European Study

Author

Anderson, H. Ross, primary, Quénel, Philippe, additional, Katsouyanni, Klea, additional, Zanobetti, Antonella, additional, Sunyer, Jordi, additional, Schouten, Jan P., additional, Wojtyniak, Bogdan, additional, Zmirou, Denis, additional, Bacharova, Ljuba, additional, Pönka, Antti, additional, and Wichmann, H.-Erich, additional

Published
1999
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147. The structural and electrical remodeling of myocardium in LVH and its impact on the QRS voltage.

Author

Bacharova L and Bacharova, Ljuba

Abstract

Electrocardiographically detected left ventricular hypertrophy (LVH) and echocardiographically detected left ventricular hypertrophy are independent predictors of cardiovascular risk, both are defined as cardiac target organ damage in hypertensive patients. However, in clinical practice the preference is given to echocardiography and the discrepant electrocardiographic (ECG) findings are underestimated or even neglected in clinical decision-making. The aim of this opinion paper was to present a view on the relation between the increased left ventricular mass and discrepant ECG findings in hypertensive patients. The concept of the "relative voltage deficit" in hypertension and in LVH assessment is presented. The current knowledge on the structural and electrical remodeling in LVH is discussed in the context of changes of active and passive electrical properties of myocardium, underlying the changes in QRS amplitude in LVH. [ABSTRACT FROM AUTHOR]

Published
2007

148. The relation between QRS amplitude and left ventricular mass in patients with hypertension identified at screening.

Author

Bacharova, Ljuba, Baum, Oleg V., Muromtseva, Galina A., Popov, Leonid A., Rozanov, Vyatcheslav B., Voloshin, Victor I., Voroshnin, Oleg M., and Zhavoronkova, Elena A.

Subjects
*ELECTROCARDIOGRAPHY, *MYOCARDIAL infarction, *HEART failure, *CORONARY heart disease treatment, *HEART disease diagnosis, *ELECTRIC properties of hearts, *THERAPEUTICS
Abstract

Objective: The aim of this study was to analyze the relationship between QRS amplitude and left ventricular mass (LVM) in hypertensive patients identified by screening, with the focus on those without left ventricular hypertrophy (LVH). Methods: The entire study group consisted of 189 healthy subjects (average 39.6 years) and 54 subjects with hypertension (average 52.4 years). The LVH-free subgroup consisted of 159 normal subjects and 30 hypertensive patients. Electrocardiograms were recorded and the magnitude of the maximum QRS spatial vector magnitude (QRSmax) was calculated from the RaVF, RV5 and SV2 amplitudes. The LVM was estimated echocardiographically. The specific potential of myocardium (SP) was calculated as a ratio of QRSmax to LVM. Results: Contrary to higher LVM values in hypertensive subjects (240.2±58.7g and 191.5±48.3 g, respectively), the QRSmax values (1.9±0.5 mV and 2.0±0.6 mV, respectively) and SP values (8.3±2.5*10-3 mV/g and 11.3±4.4*10-3 mV/g, respectively) were significantly lower as compared to healthy subjects in the entire study group. Also in the LVH-free subgroup the SP values were significantly lower in hypertensive patients (8.70±2.83*10-3 mV/g and 10.98±4.79*10-3 mV/g, respectively). The lower values of QRSmax and SP could not be explained by the differences in age and body mass index between the hypertensive patients and normal subjects. Conclusion: We showed that the SP provides a more sensitive parameter for the evaluation of early hypertrophic remodeling as compared to separated evaluation of LVM and QRS voltage already in subjects with no signs of cardiac target organ involvement according to current clinical classification. [ABSTRACT FROM AUTHOR]

Published
2007

149. Electrical and structural remodeling in left ventricular hypertrophy-a substrate for a decrease in QRS voltage?

Author

Bacharova L and Bacharova, Ljuba

Abstract

Electrical remodeling in advanced stages of cardiovascular diseases creates a substrate for triggering and maintenance of arrhythmias. The electrical remodeling is a continuous process initiated already in the early stages of cardiological pathology. The aim of this opinion article was to discuss the changes in electrical properties of myocardium in left ventricular hypertrophy (LVH), with special focus on its early stage, as well as their possible reflection in the QRS amplitude of the electrocardiogram. It critically appraises the classical hypothesis related to the QRS voltage changes in LVH. The hypothesis of the relative voltage deficit is discussed in the context of supporting evidence from clinical studies, animal experiments, and simulation studies. The underlying determinants of electrical impulse propagation which may explain discrepancies between "normal" ECG findings and increased left ventricular size/mass in LVH are reviewed. [ABSTRACT FROM AUTHOR]

Published
2007

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