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2,220 results on '"Azzarello A"'

101. The Large Observatory for x-ray timing

Author

Feroci, M, Herder, JW den, Bozzo, E, Barret, D, Brandt, S, Hernanz, M, van der Klis, M, Pohl, M, Santangelo, A, Stella, L, Watts, A, Wilms, J, Zane, S, Ahangarianabhari, M, Albertus, C, Alford, M, Alpar, A, Altamirano, D, Alvarez, L, Amati, L, Amoros, C, Andersson, N, Antonelli, A, Argan, A, Artigue, R, Artigues, B, Atteia, J-L, Azzarello, P, Bakala, P, Baldazzi, G, Balman, S, Barbera, M, van Baren, C, Bhattacharyya, S, Baykal, A, Belloni, T, Bernardini, F, Bertuccio, G, Bianchi, S, Bianchini, A, Binko, P, Blay, P, Bocchino, F, Bodin, P, Bombaci, I, Bidaud, J-M Bonnet, Boutloukos, S, Bradley, L, Braga, J, Brown, E, Bucciantini, N, Burderi, L, Burgay, M, Bursa, M, Budtz-Jørgensen, C, Cackett, E, Cadoux, FR, Caïs, P, Caliandro, GA, Campana, R, Campana, S, Capitanio, F, Casares, J, Casella, P, Castro-Tirado, AJ, Cavazzuti, E, Cerda-Duran, P, Chakrabarty, D, Château, F, Chenevez, J, Coker, J, Cole, R, Collura, A, Cornelisse, R, Courvoisier, T, Cros, A, Cumming, A, Cusumano, G, D'Ai, A, D'Elia, V, Del Monte, E, de Luca, A, de Martino, D, Dercksen, JPC, de Pasquale, M, De Rosa, A, Del Santo, M, Di Cosimo, S, Diebold, S, Di Salvo, T, Donnarumma, I, Drago, A, Durant, M, Emmanoulopoulos, D, Erkut, MH, Esposito, P, Evangelista, Y, Fabian, A, Falanga, M, and Favre, Y

Subjects
X-ray timing, X-ray spectroscopy, X-ray imaging, compact objects, X-ray detectors, microchannel plates, astro-ph.IM
Abstract

The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final downselection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supranuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m2 effective area, 2-30 keV, 240 eV spectral resolution, 1° collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study.

Published
2014

102. Tumor Budding, p53, and DNA Mismatch Repair Markers in Sinonasal Intestinal-Type Adenocarcinoma: A Retrospective Study Supports the Adverse Prognostic Impact of Tumor Budding.

Author

Puccio, Sebastiano, Azzarello, Giuseppe, Maffeis, Valeria, Laurino, Licia, Mairani, Edoardo, Conte, Federica, Tessari, Nicola, Cazzador, Diego, Zanoletti, Elisabetta, Politi, Doriano, Emanuelli, Enzo, Spinato, Giacomo, and Ausoni, Simonetta

Subjects
*PARANASAL sinus cancer, *ADENOCARCINOMA, *RISK assessment, *CANCER relapse, *RESEARCH funding, *TUMOR markers, *RETROSPECTIVE studies, *COLORECTAL cancer, *MULTIVARIATE analysis, *IMMUNOHISTOCHEMISTRY, *DNA repair, *GENE expression profiling, *GENETIC mutation, *DISEASE risk factors, MORTALITY risk factors
Abstract

Simple Summary: This study retrospectively investigates clinicopathological characteristics and survival outcomes of patients affected by sinonasal intestinal-type adenocarcinoma with tumor budding. Tumor budding was evaluated in 32 patients and allowed the identification of high budding (>4) and low budding (≤4) groups. High-budding patients had worse overall survival, higher relapse, and disease-caused death compared to low-budding patients. On multivariate analysis, considering tumor budding, therapy, and stage as covariates, tumor budding was found to be an independent prognostic factor net of the stage of disease and the type of therapy received. Other markers, such as p53, did not show any significant prognostic correlation in sinonasal intestinal-type adenocarcinoma, whereas no change in DNA mismatch repair protein expression was detected. These results reinforce the prognostic value of tumor budding in sinonasal intestinal-type adenocarcinoma, underline the potential impact of this parameter, and encourage its use in clinical practice. Sinonasal intestinal-type adenocarcinoma (ITAC) is a very rare, closely occupational-related tumor with strong histological similarities to colorectal cancer (CRC). In the latter, tumor budding (TB) is widely recognized as a negative prognostic parameter. The aim of this study was to evaluate the prognostic role of TB in ITAC and to correlate it with other established or emerging biomarkers of the disease, such as p53 and deficient DNA mismatch repair (MMR) system status/microsatellite instability (MSI). We retrospectively analyzed 32 consecutive specimens of patients with ITAC diagnosis treated in two institutions in Northern Italy. We reviewed surgical specimens for TB evaluation (low-intermediate/high); p53 expression and MMR proteins were evaluated via immunohistochemistry. Results were retrospectively stratified using clinical data and patients' outcomes. According to bud counts, patients were stratified into two groups: intermediate/high budding (>4 TB) and low budding (≤4 TB). Patients with high TB (>4) have an increased risk of recurrence and death compared to those with low TB, with a median survival of 13 and 54 months, respectively. On multivariate analysis, considering TB, therapy, and stage as covariates, TB emerged as an independent prognostic factor net of the stage of disease or type of therapy received. No impact of p53 status as a biomarker of prognosis was observed and no alterations regarding MMR proteins were identified. The results of the present work provide further significant evidence on the prognostic role of TB in ITAC and underline the need for larger multicenter studies to implement the use of TB in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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103. A Scintillating Fiber Tracker With SiPM Readout

Author

Yearwood, G. Roper, Beischer, B., Chung, Ch. -H., Doetinchem, Ph. v., Gast, H., Greim, R., Kirn, T., Schael, S., Zimmermann, N., Nakada, T., Ambrosi, G., Azzarello, P., Battiston, R., and Piemonte, C.

Subjects
Physics - Instrumentation and Detectors
Abstract

We present a prototype for the first tracking detector consisting of 250 micron thin scintillating fibers and silicon photomultiplier (SiPM) arrays. The detector has a modular design, each module consists of a mechanical support structure of 10mm Rohacell foam between two 100 micron thin carbon fiber skins. Five layers of scintillating fibers are glued to both top and bottom of the support structure. SiPM arrays with a channel pitch of 250 micron are placed in front of the fibers. We show the results of the first module prototype using multiclad fibers of types Bicron BCF-20 and Kuraray SCSF-81M that were read out by novel 32-channel SiPM arrays from FBK-irst/INFN Perugia as well as 32-channel SiPM arrays produced by Hamamatsu. A spatial resolution of 88 micron +/- 6 micron at an average yield of 10 detected photons per minimal ionizig particle has been achieved., Comment: 5 pages, 7 figures, submitted as proceedings to the 11th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD08)

Published
2008
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108. Tracker-in-Calorimeter (TIC) Project: A Calorimetric New Solution for Space Experiments

Author

Gabriele Bigongiari, Oscar Adriani, Giovanni Ambrosi, Philipp Azzarello, Andrea Basti, Eugenio Berti, Bruna Bertucci, Lorenzo Bonechi, Massimo Bongi, Sergio Bottai, Mirko Brianzi, Paolo Brogi, Guido Castellini, Enrico Catanzani, Caterina Checchia, Raffaello D’Alessandro, Sebastiano Detti, Matteo Duranti, Noemi Finetti, Valerio Formato, Maria Ionica, Paolo Maestro, Fernando Maletta, Pier Simone Marrocchesi, Nicola Mori, Lorenzo Pacini, Paolo Papini, Sergio Bruno Ricciarini, Gianluigi Silvestre, Piero Spillantini, Oleksandr Starodubtsev, Francesco Stolzi, Jung Eun Suh, Arta Sulaj, Alessio Tiberio, and Elena Vannuccini

Subjects
cosmic rays, astroparticles, γ-ray astronomy, Physics, QC1-999, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

A space-based detector dedicated to measurements of γ-rays and charged particles has to achieve a balance between different instrumental requirements. A good angular resolution is necessary for the γ-rays, whereas an excellent geometric factor is needed for the charged particles. The tracking reference technique of γ-ray physics is based on a pair-conversion telescope made of passive material (e.g., tungsten) coupled with sensitive layers (e.g., silicon microstrip). However, this kind of detector has a limited acceptance because of the large lever arm between the active layers, needed to improve the track reconstruction capability. Moreover, the passive material can induce fragmentation of nuclei, thus worsening charge reconstruction performances. The Tracker-In-Calorimeter (TIC) project aims to solve all these drawbacks. In the TIC proposal, the silicon sensors are moved inside a highly-segmented isotropic calorimeter with a couple of external scintillators dedicated to charge reconstruction. In principle, this configuration has a good geometrical factor, and the angle of the γ-rays can be precisely reconstructed from the lateral profile of the electromagnetic shower sampled, at different depths in the calorimeter, by silicon strips. The effectiveness of this approach has been studied with Monte Carlo simulations and validated with beam test data of a small prototype.

Published
2022
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109. Search for gamma-ray spectral lines with the DArk Matter Particle Explorer

Author

Yun-Feng Liang, Francesca Alemanno, Qi An, Philipp Azzarello, Felicia Carla Tiziana Barbato, Paolo Bernardini, Xiao-Jun Bi, Ming-Sheng Cai, Elisabetta Casilli, Enrico Catanzani, Jin Chang, Deng-Yi Chen, Jun-Ling Chen, Zhan-Fang Chen, Ming-Yang Cui, Tian-Shu Cui, Yu-Xing Cui, Hao-Ting Dai, Antonio De Benedittis, Ivan De Mitri, Francesco de Palma, Maksym Deliyergiyev, Margherita Di Santo, Qi Ding, Tie-Kuang Dong, Zhen-Xing Dong, Giacinto Donvito, David Droz, Jing-Lai Duan, Kai-Kai Duan, Domenico D’Urso, Rui-Rui Fan, Yi-Zhong Fan, Fang Fang, Kun Fang, Chang-Qing Feng, Lei Feng, Piergiorgio Fusco, Min Gao, Fabio Gargano, Ke Gong, Yi-Zhong Gong, Dong-Ya Guo, Jian-Hua Guo, Shuang-Xue Han, Yi-Ming Hu, Guang-Shun Huang, Xiao-Yuan Huang, Yong-Yi Huang, Maria Ionica, Wei Jiang, Jie Kong, Andrii Kotenko, Dimitrios Kyratzis, Shi-Jun Lei, Shang Li, Wen-Hao Li, Wei-Liang Li, Xiang Li, Xian-Qiang Li, Yao-Ming Liang, Cheng-Ming Liu, Hao Liu, Jie Liu, Shu-Bin Liu, Yang Liu, Francesco Loparco, Chuan-Ning Luo, Miao Ma, Peng-Xiong Ma, Tao Ma, Xiao-Yong Ma, Giovanni Marsella, Mario Nicola Mazziotta, Dan Mo, Maria Muñoz Salinas, Xiao-Yang Niu, Xu Pan, Andrea Parenti, Wen-Xi Peng, Xiao-Yan Peng, Chiara Perrina, Rui Qiao, Jia-Ning Rao, Arshia Ruina, Zhi Shangguan, Wei-Hua Shen, Zhao-Qiang Shen, Zhong-Tao Shen, Leandro Silveri, Jing-Xing Song, Mikhail Stolpovskiy, Hong Su, Meng Su, Hao-Ran Sun, Zhi-Yu Sun, Antonio Surdo, Xue-Jian Teng, Andrii Tykhonov, Jin-Zhou Wang, Lian-Guo Wang, Shen Wang, Shu-Xin Wang, Xiao-Lian Wang, Ying Wang, Yan-Fang Wang, Yuan-Zhu Wang, Da-Ming Wei, Jia-Ju Wei, Yi-Feng Wei, Di Wu, Jian Wu, Li-Bo Wu, Sha-Sha Wu, Xin Wu, Zi-Qing Xia, En-Heng Xu, Hai-Tao Xu, Zhi-Hui Xu, Zun-Lei Xu, Zi-Zong Xu, Guo-Feng Xue, Hai-Bo Yang, Peng Yang, Ya-Qing Yang, Hui-Jun Yao, Yu-Hong Yu, Guan-Wen Yuan, Qiang Yuan, Chuan Yue, Jing-Jing Zang, Sheng-Xia Zhang, Wen-Zhang Zhang, Yan Zhang, Yi Zhang, Yong-Jie Zhang, Yun-Long Zhang, Ya-Peng Zhang, Yong-Qiang Zhang, Zhe Zhang, Zhi-Yong Zhang, Cong Zhao, Hong-Yun Zhao, Xun-Feng Zhao, Chang-Yi Zhou, Yan Zhu, Francesca Alemanno, Qi An, Philipp Azzarello, Felicia Carla Tiziana Barbato , Paolo Bernardini , Xiao-Jun Bi , Ming-Sheng Cai , Elisabetta Casilli , Enrico Catanzani , Jin Chang , Deng-Yi Chenj , Jun-Ling Chen , Zhan-Fang Chen , Ming-Yang Cui , Tian- Shu Cuin , Yu-Xin Cui , Hao-Ting Dai , Antonio De Benedittis , Ivan De Mitri , Francesco de Palma , Maksym Deliyergiyev Margherita Di Santo , Qi Ding , Tie-Kuan Dong , Zhen-Xing Dong , Giacinto Donvito , David Droz, Jing-Lai Duan , Kai-Kai Duan , Domenico D’Urso , Rui-Rui Fan , Yi-Zhong Fan , Fan Fang , Kun Fang, Chang-Qin Feng , Lei Feng , Piergiorgio Fusco, Min Gao , Fabio Gargano , Ke Gong , Yi-Zhong Gong , Dong- Ya Guo , Jian-Hua Guo , Shuang-Xue Han, Yi-Ming Hu , Guang- Shun Huang , Xiao-Yuan Huang , Yong-Yi Huang , Maria Ionica , Wei Jiang , Jie Kong , Andrii Kotenko , Dimitrios Kyratzis , Shi- Jun Lei, Shang Li , Wen-Hao Li , Wei-Liang Li , Xiang Li , Xian Qiang Li , Yao-Ming Lian , Cheng-Ming Liu , Hao Liu , Jie Liu , Shu-Bin Liu , Yang Liu , Francesco Loparco , Chuan-Ning Luo , Miao Ma , Peng-Xiong Ma , Tao Ma , Xiao-Yong Ma, Giovanni Marsella, Mario Nicola Mazziotta , Dan Mo , Maria Muñoz Salinas , Xiao-Yang Niu , Xu Pan , Andrea Parenti , Wen-Xi Peng , Xiao- Yan Peng , Chiara Perrina , Rui Qiao , Jia-Ning Rao , Arshia Ruina , Zhi Shangguan , Wei-Hua Shen , Zhao-Qiang Shen , Zhong-Tao Shen , Leandro Silveri, Jing-Xing Song , Mikhail Stolpovskiy Hong Su , Meng Su , Hao-Ra Sun , Zhi-Yu Sun , Antonio Surdo , Xue-Jian Teng , Andrii Tykhonov , Jin-Zhou Wang , Lian-Guo Wang , Shen Wang , Shu-Xin Wang , Xiao-Lian Wang , Ying Wang , Yan-Fang Wang , Yuan-Zhu Wang , Da-Ming Wei , Jia-Ju Wei , Yi-Feng Wei , Di Wu , Jian Wu , Li-Bo Wu , Sha-Sha Wun , Xin Wu , Zi-Qing Xi , En-Heng Xu , Hai-Tao Xu , Zhi-Hui Xu , Zun-Lei Xu , Zi-Zong Xu , Guo-Feng Xuen , Hai-Bo Yang , Peng Yang , Ya-Qing Yang , Hui-Jun Yao , Yu-Hong Yu , Guan-Wen Yuan , Qiang Yuan , Chuan Yue , JingJing Zang Sheng-Xi Zhang , Wen-Zhang Zhang , Yan Zhang, Yi Zhangj, Yong-Jie Zhang , Yun-Long Zhang , Ya-Peng Zhang , Yong-Qiang Zhang , Zhe Zhang , Zhi-Yong Zhang , Cong Zhao , Hong-Yun Zhao , Xun-Feng Zhao , Chang-Yi Zhou , and Yan Zhu, Alemanno, Francesca, An, Qi, Azzarello, Philipp, Carla Tiziana Barbato, Felicia, Bernardini, Paolo, Bi, Xiao-Jun, Cai, Ming-Sheng, Casilli, Elisabetta, Catanzani, Enrico, Chang, Jin, Chen, Deng-Yi, Chen, Jun-Ling, Chen, Zhan-Fang, Cui, Ming-Yang, Cui, Tian-Shu, Cui, Yu-Xin, Dai, Hao-Ting, De Benedittis, Antonio, De Mitri, Ivan, DE PALMA, Francesco, Deliyergiyev, Maksym, Di Santo, Margherita, Ding, Qi, Dong, Tie-Kuang, Dong, Zhen-Xing, Donvito, Giacinto, Droz, David, Duan, Jing-Lai, Duan, Kai-Kai, D’Urso, Domenico, Fan, Rui-Rui, Fan, Yi-Zhong, Fang, Fang, Fang, Kun, Feng, Chang-Qing, Feng, Lei, Fusco, Piergiorgio, Gao, Min, Gargano, Fabio, Gong, Ke, Gong, Yi-Zhong, Guo, Dong-Ya, Guo, Jian-Hua, Han, Shuang-Xue, Hu, Yi-Ming, Huang, Guang-Shun, Huang, Xiao-Yuan, Huang, Yong-Yi, Ionica, Maria, Jiang, Wei, Kong, Jie, Kotenko, Andrii, Kyratzis, Dimitrio, Lei, Shi-Jun, Li, Shang, Li, Wen-Hao, Li, Wei-Liang, Li, Xiang, Li, Xian-Qiang, Lian, Yao-Ming, Liu, Cheng-Min, Liu, Hao, Liu, Jie, Liu, Shu-Bin, Liu, Yang, Loparco, Francesco, Luo, Chuan-Ning, Ma, Miao, Ma, Peng-Xiong, Ma, Tao, Ma, Xiao-Yong, Marsella, Giovanni, Nicola Mazziotta, Mario, Mo, Dan, Muñoz Salinas, Maria, Niu, Xiao-Yang, Pan, Xu, Parenti, Andrea, Peng, Wen-Xi, Peng, Xiao-Yan, Perrina, Chiara, Qiao, Rui, Ra, Jia-Ning, Ruina, Arshia, Shangguan, Zhi, Shen, Wei-Hua, Shen, Zhao-Qiang, Shen, Zhong-Tao, Silveri, Leandro, Song, Jing-Xing, Stolpovskiy, Mikhail, Su, Hong, Su, Meng, Sun, Hao-Ran, Sun, Zhi-Yu, Surdo, Antonio, Teng, Xue-Jian, Tykhonov, Andrii, Wang, Jin-Zhou, Wang, Lian-Guo, Wang, Shen, Wang, Shu-Xin, Wang, Xiao-Lian, Wang, Ying, Wang, Yan-Fang, Wang, Yuan-Zhu, Wei, Da-Ming, Wei, Jia-Ju, Wei, Yi-Feng, Wu, Di, Wu, Jian, Wu, Li-Bo, Wu, Sha-Sha, Wu, Xin, Xia, Zi-Qing, Xu, En-Heng, Xu, Hai-Tao, Xu, Zhi-Hui, Xu, Zun-Lei, Xu, Zi-Zong, Xue, Guo-Feng, Yang, Hai-Bo, Yang, Peng, Yang, Ya-Qing, Yao, Hui-Jun, Yu, Yu-Hong, Yuan, Guan-Wen, Yuan, Qiang, Yue, Chuan, Zann, Jing-Jing, Zhan, Sheng-Xia, Zhan, Wen-Zhang, Zhan, Yan, Zhan, Yi, Zhang, Yong-Jie, Zhang, Yun-Long, Zhang, Ya-Peng, Zhang, Yong-Qiang, Zhang, Zhe, Zhang, Zhi-Yong, Zhao, Cong, Zhao, Hong-Yun, Zhao, Xun-Feng, Zhou, Chang-Yi, and Yan Zhu, And

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Line-like structure, High Energy Physics - Experiment (hep-ex), Multidisciplinary, Astrophysics::High Energy Astrophysical Phenomena, DAMPE, Dark matter, Gamma-ray, Line-like structure, Settore FIS/01 - Fisica Sperimentale, DAMPE, Dark matter, FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena, Gamma-ray, High Energy Physics - Experiment
Abstract

The DArk Matter Particle Explorer (DAMPE) is well suitable for searching for monochromatic and sharp $\gamma$-ray structures in the GeV$-$TeV range thanks to its unprecedented high energy resolution. In this work, we search for $\gamma$-ray line structures using five years of DAMPE data. To improve the sensitivity, we develop two types of dedicated data sets (including the BgoOnly data which is the first time to be used in the data analysis for the calorimeter-based gamma-ray observatories) and adopt the signal-to-noise ratio optimized regions of interest (ROIs) for different DM density profiles. No line signals or candidates are found between 10 and 300 GeV in the Galaxy. The constraints on the velocity-averaged cross section for $\chi\chi \to \gamma\gamma$ and the decay lifetime for $\chi \to \gamma\nu$, both at 95% confidence level, have been calculated and the systematic uncertainties have been taken into account. Comparing to the previous Fermi-LAT results, though DAMPE has an acceptance smaller by a factor of $\sim 10$, similar constraints on the DM parameters are achieved and below 100 GeV the lower limits on the decay lifetime are even stronger by a factor of a few. Our results demonstrate the potential of high-energy-resolution observations on dark matter detection., Comment: 14 pages, 8 figures. Update the content to keep up with the published version

Published
2022
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110. OBSERVING GRBS WITH THE LOFT WIDE FIELD MONITOR

Author

Brandt, S., primary, Hernanz, M., additional, Feroci, M., additional, Amati, L., additional, Azzarello, Alvarez P., additional, Barret, D., additional, Bozzo, E., additional, Budtz-Jørgensen, C., additional, Campana, R., additional, Castro-Tirado, A., additional, Cros, A., additional, Del Monte, E., additional, Donnarumma, I., additional, Evangelista, Y., additional, Galvez Sanchez, J. L., additional, Gotz, D., additional, Herder, J. W. den, additional, Hornstrup, A., additional, Hudec, R., additional, Karelin, D., additional, Klis, M. van der, additional, Korpela, S., additional, Kuvvetli, I., additional, Lund, N., additional, Orleanski, P., additional, Pohl, M., additional, Rachevski, A., additional, Santangelo, A., additional, Schanne, S., additional, Schmid, C., additional, Stella, L., additional, Suchy, S., additional, Tenzer, C., additional, Vacchi, A., additional, Wilms, J., additional, Zampa, N., additional, Zand, J. J. M. in’t, additional, and Zdziarski, A., additional

Published
2020
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114. Internal alignment and position resolution of the silicon tracker of DAMPE determined with orbit data

Author

Tykhonov, A., Ambrosi, G., Asfandiyarov, R., Azzarello, P., Bernardini, P., Bertucci, B., Bolognini, A., Cadoux, F., D’Amone, A., De Benedittis, A., De Mitri, I., Di Santo, M., Dong, Y.F., Duranti, M., D’Urso, D., Fan, R.R., Fusco, P., Gallo, V., Gao, M., Gargano, F., Garrappa, S., Gong, K., Ionica, M., La Marra, D., Lei, S.J., Li, X., Loparco, F., Marsella, G., Mazziotta, M.N., Peng, W.X., Qiao, R., Salinas, M.M., Surdo, A., Vagelli, V., Vitillo, S., Wang, H.Y., Wang, J.Z., Wang, Z.M., Wu, D., Wu, X., Zhang, F., Zhang, J.Y., Zhao, H., and Zimmer, S.

Published
2018
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117. Design of an Antimatter Large Acceptance Detector In Orbit (ALADInO)

Author

Oscar Adriani, Corrado Altomare, Giovanni Ambrosi, Philipp Azzarello, Felicia Carla Tiziana Barbato, Roberto Battiston, Bertrand Baudouy, Benedikt Bergmann, Eugenio Berti, Bruna Bertucci, Mirko Boezio, Valter Bonvicini, Sergio Bottai, Petr Burian, Mario Buscemi, Franck Cadoux, Valerio Calvelli, Donatella Campana, Jorge Casaus, Andrea Contin, Raffaello D’Alessandro, Magnus Dam, Ivan De Mitri, Francesco de Palma, Laurent Derome, Valeria Di Felice, Adriano Di Giovanni, Federico Donnini, Matteo Duranti, Emanuele Fiandrini, Francesco Maria Follega, Valerio Formato, Fabio Gargano, Francesca Giovacchini, Maura Graziani, Maria Ionica, Roberto Iuppa, Francesco Loparco, Jesús Marín, Samuele Mariotto, Giovanni Marsella, Gustavo Martínez, Manel Martínez, Matteo Martucci, Nicolò Masi, Mario Nicola Mazziotta, Matteo Mergé, Nicola Mori, Riccardo Munini, Riccardo Musenich, Lorenzo Mussolin, Francesco Nozzoli, Alberto Oliva, Giuseppe Osteria, Lorenzo Pacini, Mercedes Paniccia, Paolo Papini, Mark Pearce, Chiara Perrina, Piergiorgio Picozza, Cecilia Pizzolotto, Stanislav Pospíšil, Michele Pozzato, Lucio Quadrani, Ester Ricci, Javier Rico, Lucio Rossi, Enrico Junior Schioppa, Davide Serini, Petr Smolyanskiy, Alessandro Sotgiu, Roberta Sparvoli, Antonio Surdo, Nicola Tomassetti, Valerio Vagelli, Miguel Ángel Velasco, Xin Wu, and Paolo Zuccon

Subjects
cosmic rays, antimatter, dark matter, particle detectors, space instrumentation, Physics, QC1-999, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

A new generation magnetic spectrometer in space will open the opportunity to investigate the frontiers in direct high-energy cosmic ray measurements and to precisely measure the amount of the rare antimatter component in cosmic rays beyond the reach of current missions. We propose the concept for an Antimatter Large Acceptance Detector In Orbit (ALADInO), designed to take over the legacy of direct measurements of cosmic rays in space performed by PAMELA and AMS-02. ALADInO features technological solutions conceived to overcome the current limitations of magnetic spectrometers in space with a layout that provides an acceptance larger than 10 m2 sr. A superconducting magnet coupled to precision tracking and time-of-flight systems can provide the required matter–antimatter separation capabilities and rigidity measurement resolution with a Maximum Detectable Rigidity better than 20 TV. The inner 3D-imaging deep calorimeter, designed to maximize the isotropic acceptance of particles, allows for the measurement of cosmic rays up to PeV energies with accurate energy resolution to precisely measure features in the cosmic ray spectra. The operations of ALADInO in the Sun–Earth L2 Lagrangian point for at least 5 years would enable unique revolutionary observations with groundbreaking discovery potentials in the field of astroparticle physics by precision measurements of electrons, positrons, and antiprotons up to 10 TeV and of nuclear cosmic rays up to PeV energies, and by the possible unambiguous detection and measurement of low-energy antideuteron and antihelium components in cosmic rays.

Published
2022
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118. The role of recessive inheritance in early-onset epileptic encephalopathies: a combined whole-exome sequencing and copy number study

Author

Papuc, Sorina M., Abela, Lucia, Steindl, Katharina, Begemann, Anaïs, Simmons, Thomas L., Schmitt, Bernhard, Zweier, Markus, Oneda, Beatrice, Socher, Eileen, Crowther, Lisa M., Wohlrab, Gabriele, Gogoll, Laura, Poms, Martin, Seiler, Michelle, Papik, Michael, Baldinger, Rosa, Baumer, Alessandra, Asadollahi, Reza, Kroell-Seger, Judith, Schmid, Regula, Iff, Tobias, Schmitt-Mechelke, Thomas, Otten, Karoline, Hackenberg, Annette, Addor, Marie-Claude, Klein, Andrea, Azzarello-Burri, Silvia, Sticht, Heinrich, Joset, Pascal, Plecko, Barbara, and Rauch, Anita

Published
2019
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119. Development of Cancer in Patients With Heart Failure: How Systemic Inflammation Can Lay the Groundwork

Author

Simonetta Ausoni and Giuseppe Azzarello

Subjects
cancer, heart failure, systemic inflammation, cardiokines, carcinogenesis, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

In the last decade, cardiologists and oncologists have provided clinical and experimental evidence that cancer, and not only chemotherapeutic agents, can cause detrimental effects on heart structure and function, a consequence that has serious clinical implications for patient management. In parallel, the intriguing idea that heart failure (HF) may be an oncogenic condition has also received growing attention. A number of epidemiological and clinical studies have reported that patients with HF have a higher risk of developing cancer. Chronic low-grade systemic inflammation has been proposed as a major pathophysiological process linking the failing heart to the multi-step process of carcinogenesis. According to this view, pro-inflammatory mediators secreted by the damaged heart generate a favorable milieu that promotes tumor development and accelerates malignant transformation. HF-associated inflammation synergizes with tumor-associated inflammation, so that over time it is no longer possible to distinguish the effects of one or the other. Experimental studies have just begun to search for the molecular effectors of this process, with the ultimate goal that of identifying mechanisms suitable for anti-cancer target therapy to reduce the risk of incident cancer in patients already affected by HF. In this review we critically discuss strengths and limitations of clinical and experimental studies that support a causal relationship between HF and cancer, and focus on HF-associated inflammation, cardiokines and their endocrine functions linking one and the other disease.

Published
2020
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122. DArk Matter Particle Explorer: 7 years in Space

Author

Tykhonov, Andrii, primary, Alemanno, Francesca, additional, Altomare, Corrado, additional, An, Qi, additional, Azzarello, Philipp, additional, Barbato, Felicia Carla Tiziana, additional, Bernardini, Paolo, additional, Bi, Xiao Jun, additional, Cagnoli, Irene, additional, Cai, Ming Sheng, additional, Casilli, Elisabetta, additional, Catanzani, Enrico, additional, Chang, Jin, additional, Chen, Deng Yi, additional, Chen, Jun Ling, additional, Chen, Zhan Fang, additional, Chen, Zi Xuan, additional, Coppin, Paul, additional, Cui, Ming Yang, additional, Cui, Tian Shu, additional, Cui, Yu Xin, additional, De Mitri, Ivan, additional, de Palma, Francesco, additional, Di Giovanni, Adriano, additional, Di Santo, Margherita, additional, Ding, Qi, additional, Dong, Tie Kuang, additional, Dong, Zhen Xing, additional, DONVITO, Giacinto, additional, Droz, David, additional, Duan, Jing Lai, additional, Duan, Kai Kai, additional, Fan, Rui Rui, additional, Fan, Yi Zhong, additional, Fang, Fang, additional, Fang, Kun, additional, Feng, Chang Qing, additional, Feng, Lei, additional, Fernandez Alonso, Mateo, additional, Frieden, Jennifer Maria, additional, Fusco, Piergiorgio, additional, Gao, Min, additional, Gargano, Fabio, additional, Ghose, Essna, additional, Gong, Ke, additional, Gong, Yi Zhong, additional, Guo, Dong Ya, additional, Guo, Jian Hua, additional, Han, Shuang Xue, additional, Hu, Yi Ming, additional, Huang, Guang Shun, additional, Huang, Xiao Yuan, additional, Huang, Yong Yi, additional, Ionica, Maria, additional, Jiang, Lu Yao, additional, Jiang, Wei, additional, Jiang, Yao Zu, additional, Kong, Jie, additional, Kotenko, Andrii, additional, Kyratzis, Dimitrios, additional, Lei, Shi Jun, additional, Li, Wei Liang, additional, Li, Wen Hao, additional, Li, Xiang, additional, Li, Xian Qiang, additional, Liang, Yao Ming, additional, Liu, Cheng Ming, additional, Liu, Hao, additional, Liu, Jie, additional, Liu, Shu Bin, additional, Liu, Yang, additional, Loparco, Francesco, additional, Luo, Chuan Ning, additional, Ma, Miao, additional, Ma, Peng Xiong, additional, Ma, Tao, additional, Ma, Xiao Yong, additional, Marsella, Giovanni, additional, Mazziotta, Mario Nicola, additional, Mo, Dan, additional, Niu, Xiao Yang, additional, Pan, Xu, additional, Parenti, Andrea, additional, Peng, Wen Xi, additional, Peng, Xiao Yan, additional, Perrina, Chiara, additional, Putti-Garcia, Enzo, additional, Qiao, Rui, additional, Rao, Jia Ning, additional, Ruina, Arshia, additional, Shangguan, Zhi, additional, Shen, Wei Hua, additional, Shen, Zhao Qiang, additional, Shen, Zhong Tao, additional, Silveri, Leandro, additional, Song, Jing Xing, additional, Stolpovskiy, Mikhail, additional, Su, Hong, additional, Su, Meng, additional, Sun, Hao Ran, additional, Sun, Zhi Yu, additional, Surdo, Antonio, additional, Teng, Xue Jian, additional, Wang, Jin Zhou, additional, Wang, Lian Guo, additional, Wang, Shen, additional, Wang, Xiao Lian, additional, Wang, Yan Fang, additional, Wang, Ying, additional, Wang, Yuan Zhu, additional, Wei, Da Ming, additional, Wei, Jia Ju, additional, Wei, Yi Feng, additional, Wu, Di, additional, Wu, Jian, additional, Wu, Li Bo, additional, Wu, Sha Sha, additional, Wu, Xin, additional, Xia, Zi Qing, additional, Xu, En Heng, additional, Xu, Hai Tao, additional, Xu, Jing, additional, Xu, Zhi Hui, additional, Xu, Zi Zong, additional, Xu, Zun Lei, additional, Xue, Guo Feng, additional, Yang, Hai Bo, additional, Yang, Peng, additional, Yang, Ya Qing, additional, Yao, Hui Jun, additional, Yu, Yu Hong, additional, Yuan, Guan Wen, additional, Yuan, Qiang, additional, Yue, Chuan, additional, Zang, Jing Jing, additional, Zhang, Sheng Xia, additional, Zhang, Wen Zhang, additional, Zhang, Yan, additional, Zhang, Ya Peng, additional, Zhang, Yi, additional, Zhang, Yong Jie, additional, Zhang, Yong Qiang, additional, Zhang, Yun Long, additional, Zhang, Zhe, additional, Zhang, Zhi Yong, additional, Zhao, Cong, additional, Zhao, Hong Yun, additional, Zhao, Xun Feng, additional, Zhou, Chang Yi, additional, and Zhu, Yan, additional

Published
2023
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124. A PCA-based Method for Electron-Proton Discrimination of the DAMPE Experiment

Author

Cui, Ming-Yang, primary, Alemanno, Francesca, additional, Altomare, Corrado, additional, An, Qi, additional, Azzarello, Philipp, additional, Barbato, Felicia Carla Tiziana, additional, Bernardini, Paolo, additional, Bi, Xiao Jun, additional, Cagnoli, Irene, additional, Cai, Ming Sheng, additional, Casilli, Elisabetta, additional, Catanzani, Enrico, additional, Chang, Jin, additional, Chen, Deng Yi, additional, Chen, Jun Ling, additional, Chen, Zhan Fang, additional, Chen, Zi Xuan, additional, Coppin, Paul, additional, Cui, Ming Yang, additional, Cui, Tian Shu, additional, Cui, Yu Xin, additional, De Mitri, Ivan, additional, de Palma, Francesco, additional, Di Giovanni, Adriano, additional, Di Santo, Margherita, additional, Ding, Qi, additional, Dong, Tie Kuang, additional, Dong, Zhen Xing, additional, DONVITO, Giacinto, additional, Droz, David, additional, Duan, Jing Lai, additional, Duan, Kai Kai, additional, Fan, Rui Rui, additional, Fan, Yi Zhong, additional, Fang, Fang, additional, Fang, Kun, additional, Feng, Chang Qing, additional, Feng, Lei, additional, Fernandez Alonso, Mateo, additional, Frieden, Jennifer Maria, additional, Fusco, Piergiorgio, additional, Gao, Min, additional, Gargano, Fabio, additional, Ghose, Essna, additional, Gong, Ke, additional, Gong, Yi Zhong, additional, Guo, Dong Ya, additional, Guo, Jian Hua, additional, Han, Shuang Xue, additional, Hu, Yi Ming, additional, Huang, Guang Shun, additional, Huang, Xiao Yuan, additional, Huang, Yong Yi, additional, Ionica, Maria, additional, Jiang, Lu Yao, additional, Jiang, Wei, additional, Jiang, Yao Zu, additional, Kong, Jie, additional, Kotenko, Andrii, additional, Kyratzis, Dimitrios, additional, Lei, Shi Jun, additional, Li, Wei Liang, additional, Li, Wen Hao, additional, Li, Xiang, additional, Li, Xian Qiang, additional, Liang, Yao Ming, additional, Liu, Cheng Ming, additional, Liu, Hao, additional, Liu, Jie, additional, Liu, Shu Bin, additional, Liu, Yang, additional, Loparco, Francesco, additional, Luo, Chuan Ning, additional, Ma, Miao, additional, Ma, Peng Xiong, additional, Ma, Tao, additional, Ma, Xiao Yong, additional, Marsella, Giovanni, additional, Mazziotta, Mario Nicola, additional, Mo, Dan, additional, Niu, Xiao Yang, additional, Pan, Xu, additional, Parenti, Andrea, additional, Peng, Wen Xi, additional, Peng, Xiao Yan, additional, Perrina, Chiara, additional, Putti-Garcia, Enzo, additional, Qiao, Rui, additional, Rao, Jia Ning, additional, Ruina, Arshia, additional, Shangguan, Zhi, additional, Shen, Wei Hua, additional, Shen, Zhao Qiang, additional, Shen, Zhong Tao, additional, Silveri, Leandro, additional, Song, Jing Xing, additional, Stolpovskiy, Mikhail, additional, Su, Hong, additional, Su, Meng, additional, Sun, Hao Ran, additional, Sun, Zhi Yu, additional, Surdo, Antonio, additional, Teng, Xue Jian, additional, Tykhonov, Andrii, additional, Wang, Jin Zhou, additional, Wang, Lian Guo, additional, Wang, Shen, additional, Wang, Xiao Lian, additional, Wang, Yan Fang, additional, Wang, Ying, additional, Wang, Yuan Zhu, additional, Wei, Da Ming, additional, Wei, Jia Ju, additional, Wei, Yi Feng, additional, Wu, Di, additional, Wu, Jian, additional, Wu, Li Bo, additional, Wu, Sha Sha, additional, Wu, Xin, additional, Xia, Zi Qing, additional, Xu, En Heng, additional, Xu, Hai Tao, additional, Xu, Jing, additional, Xu, Zhi Hui, additional, Xu, Zi Zong, additional, Xu, Zun Lei, additional, Xue, Guo Feng, additional, Yang, Hai Bo, additional, Yang, Peng, additional, Yang, Ya Qing, additional, Yao, Hui Jun, additional, Yu, Yu Hong, additional, Yuan, Guan Wen, additional, Yuan, Qiang, additional, Yue, Chuan, additional, Zang, Jing Jing, additional, Zhang, Sheng Xia, additional, Zhang, Wen Zhang, additional, Zhang, Yan, additional, Zhang, Ya Peng, additional, Zhang, Yi, additional, Zhang, Yong Jie, additional, Zhang, Yong Qiang, additional, Zhang, Yun Long, additional, Zhang, Zhe, additional, Zhang, Zhi Yong, additional, Zhao, Cong, additional, Zhao, Hong Yun, additional, Zhao, Xun Feng, additional, Zhou, Chang Yi, additional, and Zhu, Yan, additional

Published
2023
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125. Opening new windows for SiPMs in space experiments with the BETA ASIC

Author

Orta, Marina, primary, Guberman, D., additional, Català, R., additional, Comerma, A., additional, Espinya, A., additional, Gomez, S., additional, Mauricio, J., additional, Sanmukh, A., additional, Sanuy, A., additional, Bosch, J., additional, Lucchetta, G., additional, Rico, J., additional, Azzarello, P., additional, Frieden, J.M., additional, Perrina, C., additional, Sukhonos, D., additional, Wu, X., additional, Altomare, C., additional, Gargano, F., additional, Mazziotta, M.N., additional, Serini, D., additional, and Gascon, David, additional

Published
2023
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126. Penetrating particle ANalyzer (PAN)

Author

Sukhonos, Daniil, primary, Ambrosi, Giovanni, additional, Azzarello, Philipp, additional, Barbanera, Mattia, additional, Bergmann, Benedikt, additional, Burian, Petr, additional, Cadoux, Franck, additional, Favre, Yannick, additional, Hulsman, Johannes, additional, Iizawa, Tomoya, additional, Ionica, Maria, additional, Marra, Daniel La, additional, Mancini, Eduardo, additional, Nicola, Laurent, additional, Paniccia, Mercedes, additional, Silvestre, Gianluigi, additional, Smolyanskiy, Petr, additional, Stauffer, Jérôme, additional, Stil, Adrien, additional, Thonet, Pierre Alexandre, additional, Xie, Pengwei, additional, and Wu, Xin, additional

Published
2023
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127. Point-like Source Catalog Observed by DAMPE

Author

Duan, Kai-Kai, primary, Alemanno, Francesca, additional, Altomare, Corrado, additional, An, Qi, additional, Azzarello, Philipp, additional, Barbato, Felicia Carla Tiziana, additional, Bernardini, Paolo, additional, Bi, Xiao Jun, additional, Cagnoli, Irene, additional, Cai, Ming Sheng, additional, Casilli, Elisabetta, additional, Catanzani, Enrico, additional, Chang, Jin, additional, Chen, Deng Yi, additional, Chen, Jun Ling, additional, Chen, Zhan Fang, additional, Chen, Zi Xuan, additional, Coppin, Paul, additional, Cui, Ming Yang, additional, Cui, Tian Shu, additional, Cui, Yu Xin, additional, De Mitri, Ivan, additional, de Palma, Francesco, additional, Di Giovanni, Adriano, additional, Di Santo, Margherita, additional, Ding, Qi, additional, Dong, Tie Kuang, additional, Dong, Zhen Xing, additional, DONVITO, Giacinto, additional, Droz, David, additional, Duan, Jing Lai, additional, Duan, Kai Kai, additional, Fan, Rui Rui, additional, Fan, Yi Zhong, additional, Fang, Fang, additional, Fang, Kun, additional, Feng, Chang Qing, additional, Feng, Lei, additional, Fernandez Alonso, Mateo, additional, Frieden, Jennifer Maria, additional, Fusco, Piergiorgio, additional, Gao, Min, additional, Gargano, Fabio, additional, Ghose, Essna, additional, Gong, Ke, additional, Gong, Yi Zhong, additional, Guo, Dong Ya, additional, Guo, Jian Hua, additional, Han, Shuang Xue, additional, Hu, Yi Ming, additional, Huang, Guang Shun, additional, Huang, Xiao Yuan, additional, Huang, Yong Yi, additional, Ionica, Maria, additional, Jiang, Lu Yao, additional, Jiang, Yao Zu, additional, Kong, Jie, additional, Kotenko, Andrii, additional, Kyratzis, Dimitrios, additional, Lei, Shi Jun, additional, Li, Wei Liang, additional, Li, Wen Hao, additional, Li, Xian Qiang, additional, Liang, Yao Ming, additional, Liu, Cheng Ming, additional, Liu, Hao, additional, Liu, Jie, additional, Liu, Shu Bin, additional, Liu, Yang, additional, Loparco, Francesco, additional, Luo, Chuan Ning, additional, Ma, Miao, additional, Ma, Peng Xiong, additional, Ma, Tao, additional, Ma, Xiao Yong, additional, Marsella, Giovanni, additional, Mazziotta, Mario Nicola, additional, Mo, Dan, additional, Niu, Xiao Yang, additional, Pan, Xu, additional, Parenti, Andrea, additional, Peng, Wen Xi, additional, Peng, Xiao Yan, additional, Perrina, Chiara, additional, Putti-Garcia, Enzo, additional, Qiao, Rui, additional, Rao, Jia Ning, additional, Ruina, Arshia, additional, Shangguan, Zhi, additional, Shen, Wei Hua, additional, Shen, Zhao Qiang, additional, Shen, Zhong Tao, additional, Silveri, Leandro, additional, Song, Jing Xing, additional, Stolpovskiy, Mikhail, additional, Su, Hong, additional, Su, Meng, additional, Sun, Hao Ran, additional, Sun, Zhi Yu, additional, Surdo, Antonio, additional, Teng, Xue Jian, additional, Tykhonov, Andrii, additional, Wang, Jin Zhou, additional, Wang, Lian Guo, additional, Wang, Shen, additional, Wang, Xiao Lian, additional, Wang, Yan Fang, additional, Wang, Ying, additional, Wang, Yuan Zhu, additional, Wei, Da Ming, additional, Wei, Jia Ju, additional, Wei, Yi Feng, additional, Wu, Di, additional, Wu, Jian, additional, Wu, Li Bo, additional, Wu, Sha Sha, additional, Wu, Xin, additional, Xia, Zi Qing, additional, Xu, En Heng, additional, Xu, Hai Tao, additional, Xu, Jing, additional, Xu, Zhi Hui, additional, Xu, Zi Zong, additional, Xu, Zun Lei, additional, Xue, Guo Feng, additional, Yang, Hai Bo, additional, Yang, Peng, additional, Yang, Ya Qing, additional, Yao, Hui Jun, additional, Yu, Yu Hong, additional, Yuan, Guan Wen, additional, Yuan, Qiang, additional, Yue, Chuan, additional, Zang, Jing Jing, additional, Zhang, Sheng Xia, additional, Zhang, Wen Zhang, additional, Zhang, Yan, additional, Zhang, Ya Peng, additional, Zhang, Yi, additional, Zhang, Yong Jie, additional, Zhang, Yong Qiang, additional, Zhang, Yun Long, additional, Zhang, Zhe, additional, Zhang, Zhi Yong, additional, Zhao, Cong, additional, Zhao, Hong Yun, additional, Zhao, Xun Feng, additional, Zhou, Chang Yi, additional, and Zhu, Yan, additional

Published
2023
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129. Factors Affecting Performance of Insulin Pen Injector Technology: A Narrative Review

Author

Thomas Sparre, Laura Hammershøy, Dorte Bjerre Steensgaard, Jeppe Sturis, Per Vikkelsøe, and Antonino Azzarello

Subjects
Endocrinology, Diabetes and Metabolism, Biomedical Engineering, Internal Medicine, Bioengineering
Abstract

Background: Insulin treatment is an essential hormone replacement therapy for the survival of people with type 1 diabetes and is often used for treatment in type 2 diabetes, particularly as the disease progresses. Advances in insulin therapy have been made since its discovery, including production of human insulin and development of insulin analogs with improved efficacy and safety profiles. The different types of available insulin formulations allow health care professionals to personalize treatment to an individual’s needs. Generally, insulin requires parenteral administration via subcutaneous injection owing to very low oral bioavailability. Methods: This article reviews the human, technological, economical, and regulatory factors affecting the performance of insulin pens and the relationship between them. Opportunities and challenges that insulin pen injections may encounter in the future are also considered. Results: Insulin delivery devices, together with other factors, influence dose accuracy, convenience, and quality of life, contributing to easier medication administration with high efficacy and safety. For patients, ease of use, fast and accurate drug delivery, and painless injection are the most valuable features of an insulin injection device. For manufacturers, technological feasibility and economic viability also need to be considered when developing injection devices. Conclusion: Insulin pen injectors are generally preferred over vial and syringe, although access may be limited in some health care systems. Insulin pen injectors can adapt to different insulin regimens and formulations and have the potential to acquire dosing data in real time.

Published
2022
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130. Distinctive Role of the Systemic Inflammatory Profile in Non-Small-Cell Lung Cancer Younger and Elderly Patients Treated with a PD-1 Immune Checkpoint Blockade: A Real-World Retrospective Multi-Institutional Analysis

Author

Valerio Nardone, Rocco Giannicola, Diana Giannarelli, Rita Emilena Saladino, Domenico Azzarello, Caterina Romeo, Giovanna Bianco, Maria Rosaria Rizzo, Irene Di Meo, Antonio Nesci, Pierpaolo Pastina, Antonia Consuelo Falzea, Daniele Caracciolo, Alfonso Reginelli, Michele Caraglia, Amalia Luce, Luciano Mutti, Antonio Giordano, Salvatore Cappabianca, Luigi Pirtoli, Vito Barbieri, Pierfrancesco Tassone, Pierosandro Tagliaferri, and Pierpaolo Correale

Subjects
immune checkpoint blockade, metastatic non-small-cell lung cancer, real-world evidence study, age, inflammatory markers, immunotherapy, Science
Abstract

An immune checkpoint blockade with mAbs to PD-1 and PD-L1 is an expanding therapeutic option for mNSCLC patients. This treatment strategy is based on the use of mAbs able to restore the anti-tumor activity of intratumoral T cells inhibited by PD-1 binding to PD-L1/2 on tumor and inflammatory cells. It has been speculated that a chronic status of systemic inflammation as well as the immunosenescence physiologically occurring in elderly patients may affect the efficacy of the treatment and the occurrence of irAEs. We performed a multi-institutional retrospective study aimed at evaluating the effects of these mAbs (nivolumab or atezolizumab) in 117 mNSCLC patients younger (90 cases) and older (27 cases) than 75 years in correlation with multiple inflammatory parameters (NLR, CRP, ESR, LDH and PCT). No differences were observed when the cohorts were compared in terms of the frequency of PFS, OS, inflammatory markers and immune-related adverse events (irAEs). Similarly, the occurrence of irAEs was strictly correlated with a prolonged OS survival in both groups. On the contrary, a negative correlation between the high baseline levels of inflammatory markers and OS could be demonstrated in the younger cohort only. Overall, PD-1/PD-L1-blocking mAbs were equally effective in young and elderly mNSCLC patients; however, the detrimental influence of a systemic inflammation at the baseline was only observed in young patients, suggesting different aging-related inflammation immunoregulative effects.

Published
2021
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132. Modelling botanical biofiltration of indoor air streams contaminated by volatile organic compounds

Author

Masi, M, Guidi Nissim, W, Pandolfi, C, Azzarello, E, Mancuso, S, Masi M, Guidi Nissim W, Pandolfi C, Azzarello E, Mancuso S, Masi, M, Guidi Nissim, W, Pandolfi, C, Azzarello, E, Mancuso, S, Masi M, Guidi Nissim W, Pandolfi C, Azzarello E, and Mancuso S

Abstract

Botanical filtration is a biological-based treatment method suitable for removing hazardous volatile organic compounds (VOCs) from air streams, based on forcing an air flow through a porous substrate and foliage of a living botanical compartment. The pathways and removal mechanisms during VOC bioremediation have been largely investigated; however, their mathematical representation is well established only for the non-botanical components of the system. In this study, we evaluated the applicability of such a modelling scheme to systems which include a botanical compartment. We implemented a one-dimensional numerical model and performed a global sensitivity analysis to measure the input parameters influence on the transient and steady biofilter responses. We found that the most sensitive parameters on the transient-state behaviour were the mass transfer coefficient between gas and solid surfaces, and the fraction of solid surfaces covered by the biofilm; the steady-state response was primarily influenced by the biofilm specific surface area and the fraction of surfaces covered by the biofilm. We calibrated the identified set of parameters and successfully validated the model against data from a pilot-scale installation. The results showed that the application of the model to systems with a botanical compartment is feasible, although under a strict set of assumptions.

Published
2022

133. Nutation in Plants

Author

Mugnai, Sergio, Azzarello, Elisa, Masi, Elisa, Pandolfi, Camilla, Mancuso, Stefano, Mancuso, Stefano, editor, and Shabala, Sergey, editor

Published
2015
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135. Clinical and experimental evidence suggest a link between KIF7 and C5orf42-related ciliopathies through Sonic Hedgehog signaling

Author

Asadollahi, Reza, Strauss, Justin E, Zenker, Martin, Beuing, Oliver, Edvardson, Simon, Elpeleg, Orly, Strom, Tim M, Joset, Pascal, Niedrist, Dunja, Otte, Christine, Oneda, Beatrice, Boonsawat, Paranchai, Azzarello-Burri, Silvia, Bartholdi, Deborah, Papik, Michael, Zweier, Markus, Haas, Cordula, Ekici, Arif B, Baumer, Alessandra, Boltshauser, Eugen, Steindl, Katharina, Nothnagel, Michael, Schinzel, Albert, Stoeckli, Esther T, and Rauch, Anita

Published
2018
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136. GOLFIG Chemo-Immunotherapy in Metastatic Colorectal Cancer Patients. A Critical Review on a Long-Lasting Follow-Up

Author

Michele Caraglia, Pierpaolo Correale, Rocco Giannicola, Nicoletta Staropoli, Cirino Botta, Pierpaolo Pastina, Antonello Nesci, Nadia Caporlingua, Edoardo Francini, Laura Ridolfi, Enrico Mini, Giandomenico Roviello, Domenico Ciliberto, Rita Maria Agostino, Alessandra Strangio, Domenico Azzarello, Valerio Nardone, Antonella Falzea, Salvatore Cappabianca, Marco Bocchetti, Graziella D'Arrigo, Giovanni Tripepi, Pierfrancesco Tassone, Raffaele Addeo, Antonio Giordano, Luigi Pirtoli, Guido Francini, and Pierosandro Tagliaferri

Subjects
colorectal cancer, metastatic, chemotherapy, immunotherapy, GOLFIG, phase III clinical trial, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: GOLFIG is a chemo-immunotherapy regimen established in preclinical models that combines gemcitabine + FOLFOX (fluoropyrimidine backbone coupled to oxaliplatin) poly-chemotherapy with low-dose s. c. recombinant interleukin-2 (rIL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF). Promising antitumor effects in metastatic colorectal cancer (mCRC) patients were obtained in previous phase II and III trials. Here we report the results of 15 years of follow-up.Methods: This is a multi-institutional retrospective analysis including 179 mCRC patients receiving GOLFIG regimen between June 2002 and June 2018. Sixty-two of them received the treatment as frontline (enrolled in the GOLFIG-2 phase III trial) and 117 as second/third line (49 enrolled in the GOLFIG-1 phase II trial and 68 as compassionate use). One hundred twelve patients showed a primary left side and 67 a primary right side; K/N-ras mutational status was available in 74 cases, and an activating mutation was detected in 33. Kaplan–Meier and Cox regression analyses were carried out to relate PFS and OS with different parameters.Results: Overall, we recorded a mean PFS and OS of 15.28 (95% CI: 10.36–20.20) and 24.6 (95% CI: 19.07–30.14) months, respectively, with 14 patients surviving free of progression for 10 years. This regimen, in our updated survey of the GOLFIG-2 trial, confirmed superiority over FOLFOX in terms of PFS (hazard ratio (HR) = 0.58, p = 0.006) with a trend to a longer OS (HR = 0.69, P = 0.06) in the first line. Our analysis also confirmed significant antitumor activity in pre-treated patients, reporting a mean PFS and OS of 12.55 (95% CI: 7.19–17.9) and 20.28 (95% CI: 14.4–26.13) months, respectively. Immune-related adverse events (irAEs) were recorded in 24% of the cases and were related to a longer survival (HR = 0.36; P = 0.0001). Finally, patients' outcome was not correlated to sex, sidedness, and MT-K/N-ras.Conclusions: The GOLFIG regimen is a reliable underestimated therapeutic option in pre-treated mCRC patients and offers a strong rationale to design further trials.

Published
2019
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137. Prevalence of genetic susceptibility for breast and ovarian cancer in a non-cancer related study population: secondary germline findings from a Swiss single centre cohort

Author

Dennis Kraemer, Silvia Azzarello-Burri, Katharina Steindl, Paranchai Boonsawat, Markus Zweier, Konstantin J. Dedes, Pascal Joset, Daniel Fink, and Anita Rauch

Subjects
genetic incidentaloma, hereditary breast and ovarian cancer (HBOC), Italian, population-based screening, secondary findings, Swiss, Medicine
Abstract

BACKGROUND Since the advent of high-throughput sequencing technologies, organised germline screening, independent of the personal and family cancer history, has been frequently proposed. Since ethnic and geographic populations significantly differ in their mutation spectra and prevalence, one critical prerequisite would be the knowledge of the expected carrier frequencies. OBJECTIVE For the first time, in a retrospective non-cancer related cohort from a single Swiss genetic centre, we systematically assessed the prevalence of secondary findings in 19 genes (BRCA1/2 plus 17 non-BRCA genes) previously designated by the US National Comprehensive Cancer Network (NCCN) for hereditary breast and ovarian cancer (HBOC) germline testing. DESIGN A total of 400 individuals without a cancer diagnosis undergoing whole-exome sequencing (WES) analysis for neurodevelopmental disorders (NDDs) from 2015 to 2017 at IMG Zurich were included after quality assessment. Among these, 180 were unaffected parental couples, 27 unaffected parental singles and 13 NDD index patients (mean age 43 years). The majority of the cohort was of Caucasian ethnicity (n = 336, 84.0%) and of Northwest European ancestry (n = 202, 50.5%), for 70 of whom (42.5%) an autochthonous Swiss descent was assumed. For WES filtering of rare, potentially actionable secondary variants in HBOC genes, an overall minor allele frequency (MAF) below 0.65% was used as cut-off. Each rare variant was manually evaluated according to the recommended ACGM-AMP standards, with some adaptations including “hypomorphic” as an additional distinct pathogenicity class. RESULTS Overall, 526 rare secondary variants (339 different variants) were encountered, with the BRCA1/2 genes accounting for 27.2% of the total variant yield. If stratified for variant pathogenicity, for BRCA1/2, three pathogenic variants were found in three females of Italian ancestry (carrier frequency of 0.8%). In the non-BRCA genes, five carriers of (likely) pathogenic variants (1.3%) were identified, with two Swiss individuals harbouring the same CHEK2 Arg160Gly variant known to be recurrent among Caucasians. Hence, the overall carrier rate added up to 2.0%. Additionally, seven various hypomorphic HBOC predisposing alleles were detected in 22 individuals (5.5%). CONCLUSION We provide the first evidence of a high prevalence of HBOC-related cancer susceptibility in the heterogeneous Swiss general population and relevant subpopulations, particularly in individuals of Italian descent. These pioneering data may substantiate population-based HBOC screening in Switzerland.

Published
2019
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138. Kinetics of volatile organic compounds (VOCs) released by roasted Coffee during the first ten days after processing

Author

Ilaria Colzi, Elettra Marone, Susanna Magnelli, Stefano Mancuso, Elisa Azzarello, and Cosimo Taiti

Subjects
Coffea arabica, Coffea canephora, PTR-ToF-MS, Biology (General), QH301-705.5, Botany, QK1-989
Abstract

The quality of coffee is linked to the aroma created by the chemical reactions that occur during the roasting process. While it is generally thought that roasted coffee is a stable product with a relatively long shelf-life, little information is available on the evolution (kinetic) of the volatile organic compounds (VOCs) in the days immediately following the process. The aim of this study is to determine the evolution of VOCs released by coffee beans, on samples of Coffea arabica (three different origins) and Coffea canephora (1 single origin), by using a Proton Transfer Reaction Time-of-Flight Mass Spectrometer (PTR-ToF-MS) 24 hours after roasting, and for the next 9 days. Results confirmed the differences already highlighted in previous studies between the VOCs spectra of the two species. There were also significant differences in the intensity of emissions for the different origins of Coffea arabica, with the highest VOCs amount over time always detected in the Honduras Arabica samples. The involved detected protonated ions were grouped into three classes: compounds (ppbv) present with decreasing quantity ; weakly increasing; almost constant trend; or always increasing. A complex dynamic emerged for the different protonated ions over time, which not only affects the mass spectra of the different species but also influences the configuration of the mass spectra of the different geographical zones of production.

Published
2019
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139. The DAMPE silicon–tungsten tracker

Author

Azzarello, P., Ambrosi, G., Asfandiyarov, R., Bernardini, P., Bertucci, B., Bolognini, A., Cadoux, F., Caprai, M., De Mitri, I., Domenjoz, M., Dong, Y., Duranti, M., Fan, R., Fusco, P., Gallo, V., Gargano, F., Gong, K., Guo, D., Husi, C., Ionica, M., La Marra, D., Loparco, F., Marsella, G., Mazziotta, M.N., Mesa, J., Nardinocchi, A., Nicola, L., Pelleriti, G., Peng, W., Pohl, M., Postolache, V., Qiao, R., Surdo, A., Tykhonov, A., Vitillo, S., Wang, H., Weber, M., Wu, D., Wu, X., and Zhang, F.

Published
2016
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140. Are strong opioids equally effective and safe in the treatment of chronic cancer pain? A multicenter randomized phase IV ‘real life’ trial on the variability of response to opioids

Author

Monfredo, M., Mistretta, R., di Salemi, P.O., Zecca, E., Cartoni, C., Brunetti, G.A., Tassinari, D., Drudi, F., Rizzi, F., Pizzuto, M., Formaglio, F., Luzi, M., Narducci, F., Boscolo, G., Mangiapia, M., Artioli, F., Lazzari, M., Dauri, M., Diodati, M., Cupaiolo, A., Mameli, S., Preti, P., Ferrari, P., Vasini, G., Roy, M.T., Piva, L., Nardi, L.F., Montanari, L., Reina, V., Fusco, F., Orsi, L., Molinari, E., Corli, O., Floriani, I., Roberto, A., Montanari, M., Galli, F., Greco, M.T., Caraceni, A., Kaasa, S., Dragani, T.A., Azzarello, G., Luzzani, M., Cavanna, L., Bandieri, E., Gamucci, T., Lipari, G., Di Gregorio, R., Valenti, D., Reale, C., Pavesi, L., Iorno, V., Crispino, C., Pacchioni, M., and Apolone, G.

Published
2016
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143. Characterization of water-soluble brown carbon chromophores from wildfire plumes in the western US using size exclusion chromatography

Author

Azzarello, Lisa, Washenfelder, Rebecca A., Robinson, Michael A., Franchin, Alessandro, Womack, Caroline C., Holmes, Christopher D., Brown, Steven S., Middlebrook, Ann, Newberger, Tim, Sweeney, Colm, and Young, Cora J.

Abstract

Wildfires are an important source of carbonaceous aerosol in the atmosphere. Organic aerosol that absorbs light in the ultraviolet to visible spectral range is referred to as “brown carbon” (BrC), and its impact on Earth’s radiative budget has not been well characterized. We collected water-soluble brown carbon using a particle into liquid sampler (PILS) onboard a Twin Otter aircraft during the Fire Influence on Regional to Global Environments and Air Quality (FIREX-AQ) campaign. Samples were collected downwind of wildfires in the western United States from August to September 2019. We applied size exclusion chromatography (SEC) with ultraviolet-visible spectroscopy to characterize the molecular size distribution of BrC chromophores. The wildfire plumes had transport ages of 0 to 5 h and the absorption was dominated by chromophores with molecular weights

Published
2023

144. TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics

Author

Zhu, Jinsheng, Bailly, Aurelien, Zwiewka, Marta, Sovero, Valpuri, Di Donato, Martin, Ge, Pei, Oehri, Jacqueline, Aryal, Bibek, Hao, Pengchao, Linnert, Miriam, Burgardt, Noelia Inés, Lücke, Christian, Weiwad, Matthias, Michel, Max, Weiergräber, Oliver H., Pollmann, Stephan, Azzarello, Elisa, Mancuso, Stefano, Ferro, Noel, Fukao, Yoichiro, Hoffmann, Céline, Wedlich-Söldner, Roland, Friml, Jiří, Thomas, Clément, and Geisler, Markus

Published
2016

148. An Oxyrhynchite Education: How to Become an Apionic Scribe.

Author

Azzarello, Giuseppina

Subjects
SCRIBES, PROFESSIONAL schools, URBAN schools, EDUCATIONAL objectives, CLERKS
Abstract

This article analyzes a group of Byzantine papyri originating from the Oxyrhynchite and containing scribal exercises, which are connected to the famous domus gloriosa of the Apiones. Most of them are written on reused documents belonging to the Apionic dossier, and consist of documentary formulas or short passages copied out of other texts related to the management of the oikos. In a few cases, exercises seem to consist of copies of whole texts such as lists or accounts, so that they can be easily mistaken for real documents. Based on all these texts and on other papyrological evidence related to this issue, it is possible to argue that the oikos of the Apiones was involved in the management of a professional school located in the city of Oxyrhynchus and aiming at the education of future clerks. [ABSTRACT FROM AUTHOR]

Published
2023
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149. Cardiac wasting in head and neck cancer and in cardiac autopsies from different cancer types: A study in a chemo‐naïve setting

Author

Calamelli, Sara, primary, Noto, Samantha, additional, Baldoni, Alessandra, additional, Casarin, Alessandra, additional, Calzavara, Alessandro, additional, Bolgan, Irene, additional, Coccato, Silvia, additional, Saccà, Salvatore, additional, Laurino, Licia, additional, Azzarello, Giuseppe, additional, and Ausoni, Simonetta, additional

Published
2023
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150. Relativistic Particle Measurements in Jupiter’s Magnetosphere with Pix.PAN

Author

Hulsman, Johannes, primary, Wu, Xin, additional, Azzarello, Philipp, additional, Bergmann, Benedikt, additional, Campbell, Michael, additional, Clark, George, additional, Cadoux, Franck, additional, Ilzawa, Tomoya, additional, Kollmann, Peter, additional, Llopart, Xavier, additional, Nénon, Quentin, additional, Paniccia, Mercedes, additional, Roussos, Elias, additional, Smolyanskiy, Petr, additional, Sukhonos, Daniil, additional, and Thonet, Pierre Alexandre, additional

Published
2023
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