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Animals' mortality due to transportation infrastructure is a significant problem for some species. Scale of mortality in part depends on their behavior near railways and other transport routes. We studied the mortality and flight activity of bats in 7 double-track electrified (i.e., leading the catenary, a railway overhead electric line) railway sites in Poland. We aimed to measure the likelihood that bats use areas which pose a potential risk of collision with trains. During acoustic (ultrasound detectors) and visual (thermal imaging cameras) observations, we identified bats' positions near the railway (A — high above catenary; B — close (< 1 m) but not under catenary; C — the space destined for passing trains between tracks, traction poles, and the top of the catenary; D — at the side of the railway and next to vegetation without crossing the railway area; and E — under bridges) in different habitats (forest, water, open, urbanized). Bat activity was significantly lower (4%) in high-risk impact zone (C) than that in other zones (96%). However, bats were more prone to occur in high-risk impact zones in urbanized and open habitats, whereas, in water and forest habitats, bats occurred much less frequently. In forest sections of the railways, flights along the railway typically took place between the line and vegetation (zone D), or close to the catenary (zone B). We detected significant differences between species activity in and outside the high-impact zone (C) and other zones (A, B, D, E). Open-spaced and high-flying common noctule Nyctalus noctula usually flew or foraged above the railway area. Daubenton's bat Myotis daubentonii almost exclusively sought food above lakes or rivers and under the railway bridges. In serotines Eptesicus and pipistrelles Pipistrellus group, there was a higher tendency to use a high-risk impact zone. The search for bat casualties conducted by the researchers and a trained dog revealed one dead bat under the 50-m overpass of the two-track railway immediately following the simultaneous passage of two trains. We assumed that there is a lower chance of bat collisions with trains than with cars because of the low level of nighttime traffic on railways, when bats are active, and the specific arrangement of electrified railways. Such railways provide bats with additional open space between tracks with electrification system and the forest edge, or above the catenary for foraging and commuting. Bats utilize this space and avoid flying in the area over the track that is cluttered by the catenary; this may reduce their exposure to passing trains and the likelihood of collisions. [ABSTRACT FROM AUTHOR]

BACKGROUND: Fear of falling avoidance behavior (FFAB) is common in parkinsonisms and results in potentially mitigable downstream consequences. OBJECTIVE: Determine the characteristics of individuals with parkinsonisms most associated with FFAB. METHODS: A retrospective, cross-sectional study was conducted from medical records data of 142 patients with parkinsonisms. These data included: demographics (age, sex), disease severity (Movement Disorders Society –Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS III), years since diagnosis), fall history (number of fall injuries in previous year), and gait and balance function (five times sit to stand, MiniBESTest, Timed Up and Go (TUG), dual-task TUG, ten-meter walk test (10MWT), observed freezing of gait (FOG) (MDS-UPDRS III item 11)). RESULTS: 10MWT (p <.001) and MDS-UPDRS III item 11 (p <.014) were significantly associated with FFAB above and beyond disease severity, which also contributed significantly to the overall model (ps <.046). Fall history was not associated with FFAB. CONCLUSION: Our findings suggest that the largest portion of variability in FFAB is explained by gait velocity and FOG; however, disease severity also explains a significant portion of the variability of FFAB. Further investigation into factors predictive of FFAB and mitigation of downstream consequences, using more robust designs, is warranted. [ABSTRACT FROM AUTHOR]

Studies conducted in the field of resilience have proven the role of resilience in their clinical presentations, but few studies investigated the relationship between resilience and painrelated fear. However, there are limited studies to investigates the moderating role of self-resilience along with mediating role of avoidance behavior in fear of COVID-19. The survey questionnaire is used to collect responses from the public of Pakistan. The questionnaire sent to respondents using google forms, WhatsApp, and Facebook. A total of five hundred (500) responses were collected for data analysis. A causal relationship has been analyzed using partial least square equation modeling (PLS-SEM). This study confirmed that in the case in fear of COVID-19, avoidance behavior enhances the level of worry, Panic, and sense of helplessness. Thus, avoidance behavior holds the potential to increase COVID-19 Fear. It is further observed that self-resilience is useful in decreasing the level of Worry and Panic spread due to COVID-19 fear which means a high level of self-resilience controls the recurrence of worry and panic when and where it appears. The result of this research identified that avoidance behavior could result in increased fear. Hence the study concluded that avoidance behaviors should be adopted under some clinical therapy to overcome the fear of related issues with certain clinical recommendations. The study further concluded that stronger self-resilience can be helpful in managing persistent fear, worry, and panic. [ABSTRACT FROM AUTHOR]

Abstract Background The correlation of unintentional injury mortality to rising temperatures found in several studies could result from changes in behavior that increases exposure to hazards or risk when exposed. Temperature, precipitation and air pollutants may contribute to symptoms and distractions that increase risk or avoidance behavior that reduces risk. This study examines data that allows estimates of the relation of daily maximum temperature, precipitation and ozone pollution to injury mortality risk, each corrected statistically for the correlation with the others. Methods Daily data on unintentional injury deaths and exposures to temperature, precipitation and ozone in 9 cities in Jiangsu Province, China during 2015–2017 were analyzed using Poisson regression. The regression estimates were adjusted for weekends, holidays, an anomalous difference in death rates in Nanjing, and population size. Results Non transport injury death risk increased substantially in relation to higher temperatures when temperatures were in the moderate range and even more so at temperatures 35 degrees (C) and higher. Transport deaths were related to increasing deaths when temperatures were low but the correlation reversed at higher temperatures. Deaths were lower on rainy days when temperatures were cool and moderate with the exception of non-transport injuries when temperatures were moderate. Higher ozone concentrations were associated with more deaths except when temperatures were low. Conclusions The variations in deaths in relation to temperature, precipitation and ozone suggest that people are behaving differently or are in different environments when specific combinations of the predictor variables are prevalent, putting them at greater or less risk. More study of the behaviors and circumstances that result in injury under those conditions is needed.

COVID-19 has exposed university students to high-stress situations, and the percentage of individuals with depressive symptoms was high during the COVID-19 pandemic. Furthermore, subthreshold depression carries a risk for the subsequent development of major depressive disorder (MDD). During the COVID-19 pandemic, we examined whether differences exist between university students who deteriorated from subthreshold depression to MDD and those who remained stable or improved. Four hundred seventeen participants completed all the measures twice over a one-year interval. One hundred twenty-three participants met the criteria for subthreshold depression at Time 1. One year later, 42 participants no longer met the criteria for subthreshold depression, 68 participants maintained the criteria for subthreshold depression, and 13 participants met the criteria for MDD. We conducted two-way repeated measures ANOVA to examine the differences between those who deteriorated from subthreshold depression to MDD and those who did not. The study results suggest that avoidance behavior is associated with the development of MDD from subthreshold depression. Additionally, the study showed that experiencing isolation relates to MDD onset. Therefore, we should monitor avoidance behavior and isolation in pandemic conditions. Consequently, attention to avoidance behavior and isolation may be important; however, further research is required.

Background: Schizophrenia often involves persecutory delusions, which cause psychological distress. Some patients use online gaming as a coping tool. However, excessive online gaming has raised concerns about internet gaming disorders (IGD), while any soothing effects of online gaming on psychological distress remain unclear. Herein, we report changes in anxiety and IGD severity, measured using rating scales, in a patient with schizophrenia who used online gaming as a coping strategy for psychological distress., Case Presentation: A 43-year-old woman diagnosed with schizophrenia had worsening persecutory delusions, including that of being targeted by snipers, and had difficulty going out because of anxiety. She coped with her psychological distress using online shooting games. We assessed her state and trait anxiety, social anxiety, avoidance behavior when alone, and IGD severity. There was a notable reduction in the state anxiety score after the introduction of online gaming. The scores for trait anxiety, social anxiety, and avoidance behavior when alone decreased noticeably after the acquisition of coping strategies. This case demonstrates the presence of IGD only during the acquisition of coping strategies., Conclusion: This case highlights the potential of online gaming as a coping strategy for schizophrenia-related anxiety. However, excessive gaming can lead to IGD and thus necessitates caution. Further research should explore the applicability and potential risks of using online gaming to cope with psychological distress among patients with schizophrenia., Competing Interests: The authors declare that they have no conflict of interest., (© 2024 The Author(s). Psychiatry and Clinical Neurosciences Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.)

Study Objectives: The effectiveness of advanced emergency braking systems (AEBS) in preventing drowsy driving-related truck collisions remains unclear. We aimed to evaluate the damage-mitigation effect of AEBS on drowsy driving-related collisions involving large trucks using collision rate and damage amount., Methods: Data collected by a Japanese transportation company from 1,699 collisions involving 31,107 large trucks over 7 years were analyzed post-hoc. The collision rate (number of trucks with collisions/total number of trucks) and damage amount (total amount of property damage and personal injury) were compared based on whether the collisions were caused by drowsy or non-drowsy driving and whether the trucks were equipped with AEBS or not., Results: For all and non-drowsy driving-related collisions, the collision rate for the 12,887 trucks with AEBS (1.62 and 1.20 collisions/truck/7 years, respectively) was significantly lower than that for the 18,220 trucks without AEBS (1.94 and 1.56 collisions/truck/7 years, respectively) (p=0.04 and p=0.008, respectively). However, for drowsy driving-related collisions, the collision rate did not significantly differ between trucks with and without AEBS. The damage amount in neither type of collision (drowsy vs. non-drowsy) significantly differed between trucks with and without AEBS., Conclusions: Regarding the collision rate of large trucks, AEBS was effective in non-drowsy driving-related collisions, but not in collisions involving drowsy driving. The damage amount was not mitigated for trucks with and without AEBS regardless of the collision type. The limited effect of AEBS for damage-mitigation suggests the need for combined use with other safety-support systems that intervene in driving operations., (© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society.)

Depressed individuals exhibit an attentional bias towards mood‐congruent stimuli, yet evidence for biased processing of threat‐related information in human interaction remains scarce. Here, we tested whether an attentional bias towards interpersonally aggressive pictures over interpersonally neutral pictures could be observed to a greater extent in depressed participants than in control participants. Eye movements were recorded while the participants freely viewed visually matched interpersonally aggressive and neutral pictures, which were presented in pairs. Across the groups, participants spent more time looking at neutral pictures than at aggressive pictures, probably reflecting avoidance behavior. When the participants could anticipate the stimulus valence, depressed participants – but not controls – showed an early attentional bias towards interpersonally aggressive pictures, as indexed by their longer first fixation durations on aggressive pictures than on neutral pictures. Our results thus preliminarily suggest both an early attentional bias towards interpersonal aggression, which is present, in depressed participants, also when aggression contents are anticipated, and a later attentional avoidance of aggression. The early depression‐related bias in information processing may have maladaptive effects on the way depressed individuals perceive and function in social interaction and can, therefore, maintain depressed mood. [ABSTRACT FROM AUTHOR]

Many present-day aquatic ecosystems are defined by anthropogenic activities such as the introduction of non-native species, habitat loss, and eutrophication. On Prince Edward Island, Canada, non-native rainbow trout (Oncorhynchus mykiss) have established in highly agricultural coastal watersheds. We used acoustic telemetry with continual oxygen and temperature monitoring to explore the relationship between rainbow trout movements, low dissolved oxygen, high temperature, and other environmental parameters in the eutrophic Dunk River estuary. We tested the hypothesis that rainbow trout capitalize on increased productivity from nutrient stimulation but face a trade-off with disturbed water quality. We divided the salinity transition gradient into zones representing the transition from freshwater to seawater and established that temperature and hypoxia increased with salinity. During hypoxic periods, movements decreased, and residence increased in low salinity habitat (< 1 Practical Salinity Units, PSU) Movement between zones increased from September to November, when conditions improved. A boosted regression tree model showed that dissolved oxygen, discharge, and temperature were related to occupancy which was greatest at dissolved oxygen levels > 6 mg L−1, discharge averaging 2 m3 s−1, and temperatures below 23 °C. This study provides insights into the success of rainbow trout in eutrophic estuaries. [ABSTRACT FROM AUTHOR]

The objective of the current study was to develop a measure of fear avoidance behavior after concussion for youth and parent respondents and examine its basic psychometric properties and correlates. Children (N = 51) who were seen in a hospital concussion clinic after sustaining a concussion (M = 7.6 months, SD = 7.01) and their primary caregiver (N = 51)completed self- and informant-report measures of fear avoidance (Pediatric Fear Avoidance Behavior after Traumatic Brain Injury Questionnaire; PFAB-TBI), post-concussion symptoms (Health Behavior Inventory), emotional distress (Strengths and Difficulties Questionnaire), and quality of life (Pediatric Quality of Life Inventory Version 4.0). The self- and informant-report PFAB-TBI scores were moderately correlated (r = 0.51, p < 0.001). Neither measure demonstrated floor or ceiling effects. Both had strong internal consistency (Cronbach's α = 0.87 and 0.89, respectively). The PFAB-TBI self-report was positively correlated with somatic symptoms (r = 0.37), emotional distress (r = 0.39), and negatively associated with quality of life (r = −0.57). The PFAB-TBI informant-report was positively associated with informant reported somatic symptoms (r = 0.52) and emotional distress (r =.50) Overall, the PFAB-TBI has desirable basic measurement properties and expected correlations with clinical outcomes. This measure can potentially help clinicians and researchers better understand the impacts of fear avoidance behavior after pediatric concussion. [ABSTRACT FROM AUTHOR]

There are debates and concerns about the destination and possible contamination that engineered nanoparticles (NPs) can cause when they are deposited in water, air, or soil. Therefore, many studies have been carried under laboratory and greenhouse conditions to know the effect of NPs on soil macroinvertebrates. In the present study, under natural conditions, the effects of Fe- and Ti-NPs (0, 1, 10, 100, and 1000 mg kg−1 dry soil) on the behavior of autochthonous endogeic earthworms, the concentration of NPs in their bodies, and on the forest soil properties were studied for 60 days. Earthworms exhibited an avoidance behavior at a concentration of 1000 mg Fe-NPs kg−1 dry soil and presented lower amounts of Fe-NPs in their bodies. In contrast, in low concentrations of Fe-NPs, high amounts of Fe were found in the earthworms. Earthworms exposed to Ti-NPs avoided the consumption of NPs in all treatments evaluated. FE-SEM micrographs revealed that although earthworms had high amounts of NPs attached to their bodies, their consumption was lower. Even it was observed that the concentration of Fe in the organisms is backward proportional to the high concentrations of Fe-NPs in the soil. In contrast, the concentrations of Ti in the organisms remain constant with a limit consumption until 60 days. Autochthonous endogeic earthworms have an early sensory response independent of the type and concentration of NPs, followed by an avoidance behavior, deposition in their external tissue, and accumulation in their tissue thought of the time. Article Highlights: Fe- and Ti-nanoparticles are accumulated on autochthonous endogeic earthworms. Earthworms exhibited an avoidance behavior to engineered nanoparticles. Earthworms have an early sensory response independent of the type of nanoparticles. Earthworms could be used to evaluate the effect of Fe- and Ti-NPs in forest soils. Adhesion of nanoparticles to the worms is not indicative of their consumption. [ABSTRACT FROM AUTHOR]

There is an established relationship between anxiety and asthma, which is associated with poor health outcomes. Most previous cognitive behavior therapies (CBT) have focused on comorbid panic disorder whereas anxiety related to asthma may rather be illness-specific. The feasibility of an online CBT targeting avoidance behavior in anxiety related to asthma was evaluated, using a pretest-posttest design. Thirty participants with self-reported anxiety related to asthma were offered an eight-week treatment with therapist support. Mean adherence was good (80% of content), and most participants (89%) reported adequate relief after treatment. Catastrophizing about asthma (CAS), assessed at 2 months after treatment, improved significantly with a large effect size (Cohen's d = 1.52). All secondary outcomes, including asthma control, avoidance behavior, fear of asthma symptoms and quality of life, improved significantly with moderate to large effect sizes (d: 0.40–1.44). All improvements were stable at 4 months follow up. Weekly ratings showed that a decrease in avoidance behavior predicted a decrease in CAS the following week throughout the treatment period. We conclude that CBT targeting avoidance behavior is a feasible treatment for anxiety related to asthma. The results justify investigation of efficacy and mechanisms of change in a randomized controlled trial.ClinicalTrials.gov, ID: NCT03486756.

Earthworms shape the biological and physicochemical qualities of the soil they choose to reside in, but our understanding of the specific chemicals that attract or repel a particular species of earthworm remains incomplete. Current research indicates that some species feed on and are attracted to fungi, such as Geotrichum candidum. In the present study, as part of our continuing effort to characterize mechanisms of earthworm chemosensation, we tested whether ethyl hexanoate and ethyl pentanoate, two compounds produced by G. candidum, are appetitive to the European nightcrawler (Dendrobaena veneta). In a soil T-maze, both of these compounds significantly repelled individual earthworms in a dosage-dependent manner, this result ran counter to our initial hypothesis. D. veneta also avoided ethyl hexanoate and ethyl pentanoate in an assay we specifically developed to test an earthworms aversion to chemical stimuli in soil. In both of these assays, ethyl hexanoate was aversive at lower concentrations than ethyl pentanoate. These findings further clarify our understanding of the chemical cues that trigger the decision of D. veneta to select a particular soil-environment, and emphasize that different earthworm species may react very differently to commonly encountered chemical stimuli.

Summary: Modulation of hippocampal dentate gyrus (DG) excitability regulates anxiety. In the DG, glutamatergic mossy cells (MCs) receive the excitatory drive from principal granule cells (GCs) and mediate the feedback excitation and inhibition of GCs. However, the circuit mechanism by which MCs regulate anxiety-related information routing through hippocampal circuits remains unclear. Moreover, the correlation between MC activity and anxiety states is unclear. In this study, we first demonstrate, by means of calcium fiber photometry, that MC activity in the ventral hippocampus (vHPC) of mice increases while they explore anxiogenic environments. Next, juxtacellular recordings reveal that optogenetic activation of MCs preferentially recruits GABAergic neurons, thereby suppressing GCs and ventral CA1 neurons. Finally, chemogenetic excitation of MCs in the vHPC reduces avoidance behaviors in both healthy and anxious mice. These results not only indicate an anxiolytic role of MCs but also suggest that MCs may be a potential therapeutic target for anxiety disorders.

Objective The purpose of this study was to determine the association between fear-avoidance beliefs and disability in 3 months in people with vestibular disorders while accounting for demographic and clinical characteristics. Methods This prospective cohort study included people aged 18 to 100 years who reported dizziness. Participants were recruited from a balance disorders clinic and outpatient physical therapy clinics. All participants completed the Vestibular Activities Avoidance Instrument (VAAI) and the Hospital Anxiety and Depression Scale at baseline and the Vestibular Activities and Participation measure (VAP), dizziness Visual Analogue Scale (VAS), and 12-item Short Form Health Questionnaire at baseline and 3-month follow-up. A modified version of the VAAI included 9 items abstracted from the 81-item VAAI. The relationships between 9-item VAAI scores and follow-up measures of disability were assessed using Spearman correlation coefficients. Linear regression models were analyzed to determine the effect of fear-avoidance beliefs on follow-up VAP score while accounting for baseline outcome measures. Results All participants (n = 404) completed the baseline assessment (mean age = 54 years), and 286 (71%) completed the 3-month assessment. The mean 9-item VAAI score was 25 (SD = 14) at baseline and was significantly associated with VAP (ρ = 0.54), 12-item Short Form Health Questionnaire component scores (ρ = −0.53; −0.44), and dizziness VAS at follow-up (ρ = 0.37). Approximately 38% of the variation in VAP score at follow-up was predicted by age, number of medications, 9-item VAAI score, dizziness VAS, and Hospital Anxiety and Depression Scale-depression score when considered together (R2  = 0.38). Conclusion Fear-avoidance beliefs are associated with measures of disability at 3 months and are predictive of activity limitations and participation restrictions at 3 months when controlling for age, medications, baseline dizziness, and depression symptom severity in people with vestibular disorders. Impact Measurement of fear-avoidance beliefs may provide important prognostic information, suggesting that an assessment of fear-avoidance beliefs could be used by clinicians to identify individuals at greater risk of disability after a vestibular disorder. Lay Summary Fear-avoidance beliefs in people who have vestibular disorders are associated with disability at 3 months and predict limitations in daily activities at 3 months. [ABSTRACT FROM AUTHOR]

Earthworms shape the biological and physicochemical qualities of the soil they choose to reside in, but our understanding of the specific chemicals that attract or repel a particular species of earthworm remains incomplete. Current research indicates that some species feed on and are attracted to fungi, such as Geotrichum candidum. In the present study, as part of our continuing effort to characterize mechanisms of earthworm chemosensation, we tested whether ethyl hexanoate and ethyl pentanoate, two compounds produced by G. candidum, are appetitive to the European nightcrawler (Dendrobaena veneta). In a soil T-maze, both of these compounds significantly repelled individual earthworms in a dosage-dependent manner, this result ran counter to our initial hypothesis. D. veneta also avoided ethyl hexanoate and ethyl pentanoate in an assay we specifically developed to test an earthworms aversion to chemical stimuli in soil. In both of these assays, ethyl hexanoate was aversive at lower concentrations than ethyl pentanoate. These findings further clarify our understanding of the chemical cues that trigger the decision of D. veneta to select a particular soil-environment, and emphasize that different earthworm species may react very differently to commonly encountered chemical stimuli. [ABSTRACT FROM AUTHOR]

As rare earth (RE) metals are abundantly present in the soil, in spite of their name, it is conceivable that organisms may encounter and interact with RE ions. In the present study, we demonstrated that the soil nematode Caenorhabditis elegans avoids RE ions, such as yttrium and all examined lanthanide ions, which exhibit toxic effects on nematodes. We also demonstrated that the chemosensory system of this animal mediates avoidance behavior toward RE ions similar to heavy metal (HM) ion avoidance. The C. elegans dyf-11(pe554) mutant is unable to respond to chemosensory cues because it lacks all ciliated endings of the chemosensory neurons required for the detection of environmental chemicals. Cell-specific rescue of the dyf-11 mutant and cell-specific genetic ablation studies revealed that the avoidance behavior toward HM and RE ions was mediated by a partially overlapping but distinct subset of chemosensory neurons (ASH, ADL, ASE, ADF, and ASK). With the help of multiple chemosensory neurons, worms may improve the fidelity of avoidance behavior to evade RE ions. Among the chemosensory neurons in C. elegans, ADF and ASK neurons were involved in RE avoidance, but not in HM avoidance. These results suggested that ADF and ASK neurons in C. elegans have RE-selective mechanisms to mediate the avoidance response. [ABSTRACT FROM AUTHOR]

Psychological treatments of MS-related fatigue mostly depend on energy conservation programs. We argue that the evidence for energy conservation training is weak – in contrast to some reviews on this topic. The reasons for our concerns are the use of informed passive control groups allowing negative placebo effects, the lack of predefined primary outcome parameter, statistically rather than clinically significant effects, and the use of insensitive fatigue questionnaires. We propose to base psychological interventions not on a view of fatigue as a constant loss of mental energy but as a subjective representation ("feeling") of an inflammatory state, which draws away attentional capacity. This conceptualization allows to develop a three-step treatment approach: Getting short-term control on fatigue, extinction to reduce fatigue-related avoidance behavior, and a systematic increase of activities by pacing. Our proposal depends on the techniques, that can interrupt ongoing feelings of fatigue and can serve as a basis for extinction. We propose that Progressive Muscle Relaxation might be such a technique. The advantage of our model is that it shares similarities with well-established treatments for phobias and chronic pain and we discuss the shared set of assumptions. Hopefully, this will help to improve the treatment of fatigue in future. • We propose that fatigue in MS involves a sensory component reflecting the state of the immune system. • The predetermined consequence of this feeling is a reduction of behavior. • The main treatment goal is to learn a strategy to distract attention from the feeling of fatigue. • The second step therefore includes graded exposition by executing the fatigue-reducing strategy. • A central element of the treatment should be a systematic reconditioning program to enhance fitness. [ABSTRACT FROM AUTHOR]

Our understanding of individuals' response to information about unregulated contaminants is limited. We leverage the highly publicized social discovery of unregulated PFAS (per- and polyfluoroalkyl substances) contamination in public drinking water to study the impact of information about unregulated contaminants on housing prices. Using residential property transaction data, we employ a difference-in-differences research design and show that high profile media coverage about PFAS contamination significantly decreased property values of affected homes. We also find suggestive evidence of residential sorting that may have worsened environmental inequality. [ABSTRACT FROM AUTHOR]

Abstract Background Intramuscular adipose tissue (IMAT) is a feature of degenerative muscle composition and is a common feature in populations with chronic low back pain (CLBP). Avoidance behavior is a possible cause of morphological muscle composition due to disuse of the paraspinal muscles. Therefore it is of clinical interest to determine the association between fear-avoidance beliefs and IMAT of the paraspinal muscles in populations with CLBP. Methods In this cross-sectional study, we examined twenty-four adults, featuring a mean age of 48.63 years (SD ± 14.73), with CLBP. Axial T2-weighted Magnetic Resonance Imaging (MRI) images were selected on the same level as the intervertebral disc of segments L4-L5 and L5-S1. After determine the region of interest, the amount of IMAT was measured by an automatic-threshold method to distinguish fat from muscle tissue. Fear-avoidance beliefs were measured with the Fear-Avoidance Beliefs Questionnaire, with regard to Physical Activity (FABQ-PA). Bivariate correlation and multiple regression analysis were used to determine the association between IMAT of the paraspinal muscles and fear-avoidance beliefs. Results There is a significant bivariate association between the FABQ-PA and ES IMAT (r = 0.484, P = 0.017), but not for LMM (r = 0.228, P = 0.284). The association between the FABQ-PA and ES IMAT remained moderate after adjusting for covariates (β = 0.381, P = 0.028). Conclusion Fear-avoidance beliefs are moderately associated with ES IMAT and poorly associated with LMM IMAT in a population with CLBP. Results should be interpreted with caution due to a small and selected study population.

Background: Cognitive-affective factors influence the perception of pain and disability. These factors can lead to pain behaviors (PB) that can persist and become maladaptive. These maladaptive PB will further increase the risk of chronicity or persistence of symptoms and disability. Thus, clinicians must be prepared to recognize maladaptive PB in a clinical context. To date, in the context of assessment in a rehabilitation setting, PB in clinical settings are poorly documented. The main objective of this study was to identify direct observation methods and critically appraise them in order to propose recommendations for practice. As a secondary objective, we explored and extracted the different observable PB that patients could exhibit and that clinicians could observe. Methods: We conducted a comprehensive review on four databases with a generic search strategy in order to obtain the largest range of PB. For the first objective, a two-step critical appraisal used clinical criteria (from qualitative studies on barriers to implement routine measures) and psychometric criteria (from Brink and Louw critical appraisal tool) to determine which observation methods could be recommended for clinical practice. For the second objective, we extracted PB found in the literature to list potential PB that patients could exhibit, and clinicians could observe. Results: From the 3362 retrieved studies, 47 met the inclusion criteria for the first objective. The clinical criteria allowed us to select three observation methods. After the psychometric step, two observation methods were retained and recommended for clinical practice: the Behavioral Avoidance Test-Back Pain (BAT-Back) and the Pain Behaviour Scale (PaBS). For the second objective, 107 studies met the inclusion criteria. The extraction of the PB allowed us to list a large range of PB and classify the data in 7 categories of PB. Conclusion: Our results allowed us to recommend two observation methods for clinical practice. However, these methods have limitations and are validated only in chronic low back pain populations. With the extraction of PB presented in the literature, we contribute to better prepare clinicians to recognize PB in all patients who are experiencing pain. [ABSTRACT FROM AUTHOR]

Objective The purpose of this study was to investigate how various physical and psychological factors are linked to disability attributed to symptoms from increased interrecti distance (IRD) in women after childbirth. Methods In this cross-sectional observational study, 141 women with an IRD of at least 2 finger-widths and whose youngest child was between the ages of 1 and 8 years participated. A multiple linear regression model was performed, with disability as the outcome variable and fear-avoidance beliefs, emotional distress, body mass index, lumbopelvic pain, IRD, and physical activity level as predictor variables. Results The regression model accounted for 60% (R 2 = 0.604, adjusted R 2 = 0.586) of the variance in disability (F6,132 = 33.5). The 2 strongest predictors were lumbopelvic pain, with a regression coefficient of 1.4 (95% CI = 1.017 to 1.877), and fear avoidance, with a regression coefficient of 0.421 (95% CI = 0.287 to 0.555). The actual IRD, with a regression coefficient of −0.133 (95% CI = −1.154 to 0.888), did not contribute significantly to the variation in disability. Conclusion Disability attributed to symptoms from an increased IRD is explained primarily by the level of lumbopelvic pain but also by the degree of fear-avoidance beliefs and emotional distress. Impact This study highlights pain intensity and psychological factors as crucial factors for understanding disability attributed to increased IRD. [ABSTRACT FROM AUTHOR]

The different periods characterizing spring-calving, pasture-based dairy systems common in Ireland have seldom been the focus of large-scale dairy cow welfare research. Thus, the aim of this study was to devise and conduct an animalbased welfare assessment during both the grazing and housing periods on spring-calving, pasture-based dairy farms, to identify areas for improvement and establish benchmarks for indicators of good welfare. Assessment of seven animalbased welfare indicators was conducted during two visits (one each at grazing and housing) to 82 commercial dairy farms in southern Ireland. Herd-level descriptive statistics were performed for all welfare indicators at each visit, and differences between visits were analyzed using paired t-tests and Wilcoxon signed-rank tests. A mean of 9% and 10% clinically lame cows (mobility scores 2 and 3) were observed at housing and grazing, respectively. Recommended body condition scores (BCS) were not met for a mean of 13% of cows at grazing and 23% at housing, with more over-conditioned cows present at housing than grazing (P < 0.001). Ocular discharge was uncommon in both periods. Prevalence of moderate and severe nasal discharge combined was lower during housing (5%) than grazing (7%). In both periods, similar mean levels of tail injury were observed: 2% to 3% of cows with tail lacerations, 9% with broken tails, and 8% (measured at housing only) with docked tails. Integument alterations involved primarily hair loss and were most prevalent on the hindquarters (26%) during grazing and on the head–neck–back (66%) and the hindquarter (32%) regions during housing. Cows displayed an avoidance distance of >1 m (indicative of a fearful response) from an approaching human in an average of 82% of grazing cows and 42% to 75% of housed cows, dependent on test location. Opportunities to improve welfare in this system were identified in the areas of tail injury prevention, nasal health, and the management of indoor housing and feeding. The performance of the top 20% of farms for each welfare indicator was used to establish benchmarks of: 0% to 5% clinical lameness, 0% to 12% of cows outside recommended BCS, 0% to 27% ocular discharge, 2% to 16% nasal discharge, 0% tail lacerations and docked tails, 0% to 3% tail breaks, 0% to 14% integument alterations, and 4% to 74% for avoidance distance of >1 m. These represent attainable targets for spring-calving pasture-based farms to promote good dairy cow welfare. [ABSTRACT FROM AUTHOR]

Using detailed data on the beneficiaries of the Korean National Health Insurance Service (c.2006–2015), this paper estimates the health effects of air pollution in South Korea while controlling for avoidance behaviors. In particular, we investigate changes in respiratory hospitalization rates due to increases in PM 10 and O 3 concentrations. To address the endogeneity of air pollution, this paper applies the historical average concentration of air pollution, which includes rich information about the meteorological and geographical factors that affect regional air pollution levels, as an instrumental variable and compares the results with other count data models. We find that a 10 μ g/m 3 increase in PM 10 and a 10 ppb increase in O 3 lead to an increase in daily respiratory hospital visits of up to 10.39% [95% confidence interval (CI) 4.04–16.80] and 10.93% (95% CI 9.23–12.63), resulting in additional health care costs of US$67 million and US$70 million, respectively. This paper also shows that the effects of PM 10 and O 3 are elevated in highly populated cities, children, and patients without chronic respiratory diseases. [ABSTRACT FROM AUTHOR]

Background: The novel coronavirus disease-2019 (COVID-19) has seriously affected the lives of millions of people across the world. It has also heavily burdened healthcare professionals and the virus poses serious risks for their personal and professional lives. Therefore, the present study examined the associations between fear of COVID-19 and workplace phobia among doctors in Pakistan during the COVID-19 pandemic.Methods: An online survey was conducted among 421 doctors in Pakistan between April 10 and May 25, 2020. The Workplace Phobia Scale (WPS) and the Fear of COVID-19 Scale (FCV-19S) were the main psychometric instruments used in this study.Results: There was a significant positive relationship between fear of COVID-19 and workplace panic anxiety and workplace avoidance behavior. Significantly higher fear of COVID-19 was found among (i) females compared to males, (ii) doctors with 5 years or less of work experience compared to those with more than 5 years, and (iii) postgraduate trainees compared with other ranks. Two groups (doctors who were above 30 years old and postgraduate trainees) were found to have higher levels of workplace phobia compared to their counterparts. Doctors with severe levels of fear of COVID-19 had significantly higher levels of workplace panic anxiety and workplace avoidance behavior.Conclusions: Fear of COVID-19 was significantly associated with workplace phobia which may negatively affect doctors' performance. Therefore, important steps are needed to protect doctors' health by providing sufficient resources to allay their fears and anxieties which consequently help them in carrying out their frontline duties in response to the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Staying home and avoiding unnecessary contact is an important part of the effort to contain COVID-19 and limit deaths. Every state in the United States enacted policies to encourage distancing and some mandated staying home. Understanding how these policies interact with individuals' voluntary responses to the COVID-19 epidemic is a critical initial step in understanding the role of these nonpharmaceutical interventions in transmission dynamics and assessing policy impacts. We use variation in policy responses along with smart device data that measures the amount of time Americans stayed home to disentangle the extent that observed shifts in staying home behavior are induced by policy. We find evidence that stay-at-home orders and voluntary response to locally reported COVID-19 cases and deaths led to behavioral change. For the median county, which implemented a stay-at-home order with about two cases, we find that the response to stay-at-home orders increased time at home as if the county had experienced 29 additional local cases. However, the relative effect of stay-at-home orders was much greater in select counties. On the one hand, the mandate can be viewed as displacing a voluntary response to this rise in cases. On the other hand, policy accelerated the response, which likely helped reduce spread in the early phase of the pandemic. It is important to be able to attribute the relative role of selfinterested behavior or policy mandates to understand the limits and opportunities for relying on voluntary behavior as opposed to imposing stay-at-home orders. [ABSTRACT FROM AUTHOR]

In this article, we examine the correlates of fear of violence in the cross-media landscape. The study draws on the Finnish National Crime Victim Survey (n = 6,141, respondents aged 15–74 years). First, we examine from what information and media sources respondents receive information on violent crime. We then examine how consumption of different types of media and information sources on violent crime associates with the contemporary experience of fear of street violence, avoidance behavior due to threat of violence, and perceived threat of terrorism to oneself. We also examine whether this association remains when age, gender, education, past victimization, and economic strain are adjusted for. [ABSTRACT FROM AUTHOR]

The ability to perceive and exercise control is a major contributor to our mental and physical wellbeing. When faced with uncontrollable aversive stimuli, organisms develop heightened anxiety and become unwilling to exert effort to avoid the stimuli. In contrast, when faced with controllable aversive stimuli, organisms demonstrate behavioral vigor via avoidance attempts toward trying to seek and exercise control over the environment. As such, controllability confers protective effects against reduced avoidance motivation trigged by aversive environments. These observations beg the question of whether controllability can be potent enough to reverse passivity following repeated exposure to uncontrollable aversive stimuli and how this protective effect is encoded neurally. Human participants performed a Control in Aversive Domain (CAD) task where they were first subjected to a series of repeated uncontrollable aversive stimuli (i.e., aversive tones) across several contexts that were followed by a series of controllable aversive stimuli in a novel context. Faced with persistent uncontrollability, participants significantly reduced their avoidance attempts over time and biased toward giving up. However, the subsequent presence of controllability rescued participants’ avoidance behavior. Strikingly, participants who responded more strongly to the protective effects of control also had greater ventromedial prefrontal cortical (vmPFC) activation—a region previously observed to be associated with encoding the subjective value of control. Taken together, these findings highlighted the protective effect conferred by perceived control against passivity and offered insights into the potential role of the vmPFC in controllable environments, with implications for understanding the beneficial influence of perceived control on adaptive behavior.

This study provides new empirical evidence on the relationship between information about air pollution and avoidance behavior. Many countries provide real-time information to describe the current level of air pollution exposure. However, little research has been done on people's reactions to that real-time information. Using data on attendance at professional baseball games in South Korea, this study investigates whether real-time information on particulate matter affects individuals' decisions to participate in outdoor activities. Regression models that include various fixed effects are used for the analysis, with the results showing that real-time alerts reduce the number of baseball game spectators by 7%, and that the size of the effect is not statistically different from that of air pollution forecasts. The study demonstrates that providing real-time information can be a way to protect the public's health from the threat of air pollution. Moreover, the findings suggest that having easy access to the relevant information and an awareness of the risks involved are necessary for a real-time information policy to succeed. [ABSTRACT FROM AUTHOR]

The ability to perceive and exercise control is a major contributor to our mental and physical wellbeing. When faced with uncontrollable aversive stimuli, organisms develop heightened anxiety and become unwilling to exert effort to avoid the stimuli. In contrast, when faced with controllable aversive stimuli, organisms demonstrate behavioral vigor via avoidance attempts toward trying to seek and exercise control over the environment. As such, controllability confers protective effects against reduced avoidance motivation trigged by aversive environments. These observations beg the question of whether controllability can be potent enough to reverse passivity following repeated exposure to uncontrollable aversive stimuli and how this protective effect is encoded neurally. Human participants performed a Control in Aversive Domain (CAD) task where they were first subjected to a series of repeated uncontrollable aversive stimuli (i.e., aversive tones) across several contexts that were followed by a series of controllable aversive stimuli in a novel context. Faced with persistent uncontrollability, participants significantly reduced their avoidance attempts over time and biased toward giving up. However, the subsequent presence of controllability rescued participants' avoidance behavior. Strikingly, participants who responded more strongly to the protective effects of control also had greater ventromedial prefrontal cortical (vmPFC) activation—a region previously observed to be associated with encoding the subjective value of control. Taken together, these findings highlighted the protective effect conferred by perceived control against passivity and offered insights into the potential role of the vmPFC in controllable environments, with implications for understanding the beneficial influence of perceived control on adaptive behavior. [ABSTRACT FROM AUTHOR]

Governments throughout the globe usually implement early warning systems to prevent health-related costs from exposure to extreme heat. In a warming world, this type of information-provision approach is believed to be an effective way to deal with this natural hazard, even when there is little evidence of its influence on individuals' behavior. Using detailed information from 1 million trips recorded by a bike-sharing system in Buenos Aires, Argentina, this paper investigates the direct behavioral impact of heat warnings on cycling trips. The results show substantial avoidance behavior for female cyclists and older users: the number of trips for those groups decreases following a heat warning. Alternative specifications for temperature and falsification tests suggest that the findings are robust. As in other studies, this paper also shows that the impact is diluted as time under alert increases. [ABSTRACT FROM AUTHOR]

Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel that is broadly expressed in sensory pathways, such as the trigeminal and vagus nerves. It is capable of detecting various irritants in inspired gasses and is activated during hypoxia. In this study, the role of TRPA1 in hypoxia-induced behavioral, respiratory, and cardiovascular responses was examined through four lines of experiments using TRPA1 knockout (KO) mice and wild type (WT) littermates. First, KO mice showed significantly attenuated avoidance behavior in response to a low (15%) oxygen environment. Second, the wake-up response to a hypoxic ramp (from 21 to 10% O2 in 40 s) was measured using EEG electrodes. WT mice woke up within 30 s when oxygen was at 13–14%, but KO mice did not wake up until oxygen levels reached 10%. Histological analysis confirmed that mild (13% O2) hypoxia resulted in an attenuation of trigeminal neuronal activation in KO mice. Third, the ventilatory response to hypoxia was measured with whole body plethysmography. KO mice showed attenuated responses to mild hypoxia (15% O2) but not severe hypoxia (10% O2). Similar responses were observed in WT mice treated with the TRPA1 blocker, AP-18. These data clearly show that TRPA1 is necessary for multiple mild hypoxia (13–15% O2)-induced physiological responses. We propose that TRPA1 channels in the sensory pathways innervating the airway can detect hypoxic environments and prevent systemic and/or cellular hypoxia from occurring.

Fear of natural enemies in non-human animals is a concept dating back to the time of Darwin. Now recognized as a non-consumptive effect, the ecological and evolutionary impact of fear has been studied in a number of predator-prey systems within the last few decades. However, comparatively little consideration has been given to the non-consumptive effects that parasites have on their hosts, which have evolved behaviors to avoid parasites, impacting habitat selection, mate choice, and foraging activity. These avoidance behaviors create a “landscape of disgust,” wherein hosts navigate to avoid parasites, akin to the “landscape of fear” in prey. Evolutionarily speaking, however, predators and parasites are but two examples of natural enemies. Pathogens, parasites, predators, and parasitoids, among others, each exert their own fitness cost on the victims they attack. Since animals likely evolve in the presence of multiple natural enemies, they must adopt a range of avoidance behaviors to navigate through the resulting “landscape of peril.” Therefore, in line with recent efforts to combine the landscapes of fear and disgust, we offer a theoretical framework to better understand the impacts of natural enemies on the evolution of trait-mediated avoidance behaviors in animals. More precisely, we look at how victims may evolve to allocate energy optimally among distinct avoidance behaviors under the selective pressures imposed by different types of natural enemy. This framework is then put into the more realistic context of a food web, which highlights the impact of trophic interactions and trophic level on the evolution of avoidance behaviors.

Animals adopt a range of avoidance strategies to reduce their exposure to parasites and the associated cost of infection. If strong selective pressures from parasites are sustained over many generations, avoidance strategies may gradually evolve from phenotypically plastic, or individually variable, to fixed, species-wide traits. Over time, host species possessing effective infection avoidance traits may lose parasite species. Indeed, if overcoming the avoidance strategies of a host species is too costly, i.e., if individuals of that species become too rarely encountered or difficult to infect, a generalist parasite may opt out of this particular arms race. From the host’s perspective, if avoidance traits are not costly or have been co-opted for other functions, they may persist in extant species even if ancestral parasites are lost, as signatures of past selection by parasites. Here, we develop the “ghost of parasitism past” hypothesis. We discuss how animal species with a lower number of parasite species than expected based on their ecological properties or phylogenetic affinities are a good starting point in the search for traces of past parasite-mediated selection. We then argue that the hypothesis explains the dynamic and inconsistent nature of the relationship between the expression of avoidance traits and relative infection risk in comparative analyses across host species. Finally, we propose some approaches to test the predictions of the hypothesis. Animal morphology and behavior show clear evidence of past selective pressures from predators; we argue that past selection from parasites has also left its imprint, though in more subtle ways.

Abstract Background The avoidance-endurance model suggests both fear-avoidance responses and endurance-related responses could affect the chronicity of pain. Proper pain intervention requires measuring fear-avoidance responses and endurance-related responses but no Korean language questionnaire has yet been made to measure them. The purpose of this study was to evaluate the validity and reliability of the Korean version of the Avoidance-Endurance Behavior Questionnaire (K-AEQ-Behavior) by adapting the behavioral responses of Avoidance-Endurance Questionnaire into Korean language. Methods The K-AEQ-Behavior was forward and backward translated based on the standards for instrument translation. A total of 136 outpatients with chronic pain of a duration exceeding 3 months were recruited from a pain center at a university hospital in Seoul, Korea. Two weeks later, the K-AEQ-Behavior was re-administered to 36 patients for test-retest reliability. Exploratory factor analysis was performed using principle axis factoring. The internal consistency, test-retest reliability, and concurrent validity of the K-AEQ-Behavior were measured by Cronbach’s ⍺, intraclass correlation coefficient, and Pearson correlation coefficient, respectively. Results Although the four-factor structure (23 items) was derived in the original study, the two-factor structure of avoidance behavior and endurance behavior (21 items) was derived in the exploratory factor analysis of the Korean version in this study. Other results indicated that K-AEQ-Behavior has good internal consistency, test-retest reliability and concurrent validity. Conclusion This study suggests that the K-AEQ-Behavior is a reliable and valid instrument for assessing avoidance behavior and endurance behavior in patients with chronic pain.

Aim and Background: Generalized Anxiety Disorder (GAD) is one of the basic disorders in psychopathology. Therefore, the aime of this study was to develop a conceptual model for the role of spiritual coping and cognitive emotion regulation strategies as moderating and mediating factors in the relationship between transdiagnostic factors and symptoms of GAD. Methods and Materials: In this descriptive-correlational study, 700 undergraduate students were selected by multi-stage cluster sampling method from public universities of Tehran, Iran. The participants completed Generalized Anxiety Disorder (7-item) (GAD-7) Scale, Penn state Worry Questionnaire (PSWQ), Cognitive Avoidance Questionnaire (CAQ), Intolerance of Uncertainty Scale (IUS), Metacognition Questionnaire (MCQ), Cognitive Emotion Regulation Questionnaire (CERQ), Acceptance and Action Questionnaire-II (AAQ-II), and Spiritual Coping Questionnaire (SCQ). Data were analyzed by SPSS, Process, and LISREL softwares using path analysis method and structural equations. Findings: There was a significant relationship between transdiagnostic factors (cognitive avoidance, negative beliefs about worry, intolerance of uncertainty, and experiential avoidance,) and symptoms of GAD (P < 0.050). Also, there was a significant relationship between transdiagnostic factors with cognitive emotion regulation strategies and spiritual coping (P < 0.050). Results showed that cognitive emotion regulation strategies mediated the relationship between transdiagnostic factors and symptoms of GAD, and spiritual coping moderated the relationship between transdiagnostic factors and symptoms of GAD. Conclusions: The results of this study emphasize the importance of transdiagnostic factors, cognitive emotion regulation, and spiritual coping in symptoms of GAD.

Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel that is broadly expressed in sensory pathways, such as the trigeminal and vagus nerves. It is capable of detecting various irritants in inspired gasses and is activated during hypoxia. In this study, the role of TRPA1 in hypoxia-induced behavioral, respiratory, and cardiovascular responses was examined through four lines of experiments using TRPA1 knockout (KO) mice and wild type (WT) littermates. First, KO mice showed significantly attenuated avoidance behavior in response to a low (15%) oxygen environment. Second, the wake-up response to a hypoxic ramp (from 21 to 10% O2 in 40 s) was measured using EEG electrodes. WT mice woke up within 30 s when oxygen was at 13–14%, but KO mice did not wake up until oxygen levels reached 10%. Histological analysis confirmed that mild (13% O2) hypoxia resulted in an attenuation of trigeminal neuronal activation in KO mice. Third, the ventilatory response to hypoxia was measured with whole body plethysmography. KO mice showed attenuated responses to mild hypoxia (15% O2) but not severe hypoxia (10% O2). Similar responses were observed in WT mice treated with the TRPA1 blocker, AP-18. These data clearly show that TRPA1 is necessary for multiple mild hypoxia (13–15% O2)-induced physiological responses. We propose that TRPA1 channels in the sensory pathways innervating the airway can detect hypoxic environments and prevent systemic and/or cellular hypoxia from occurring. [ABSTRACT FROM AUTHOR]

Caenorhabditis elegans secretes a complex cocktail of small chemicals collectively called ascaroside pheromones which serves as a chemical language for intra-species communication. Subsets of ascarosides have been shown to mediate a broad spectrum of C. elegans behavior and development, such as gender-specific attraction, repulsion, aggregation, olfactory plasticity, and dauer formation. Recent studies show that specific components of ascarosides elicit a rapid avoidance response that allows animals to avoid predators and escape from unfavorable conditions. Moreover, this avoidance behavior is modulated by external conditions, internal states, and previous experience, indicating that pheromone avoidance behavior is highly plastic. In this review, we describe molecular and circuit mechanisms underlying plasticity in pheromone avoidance behavior which pave a way to better understanding circuit mechanisms underlying behavioral plasticity in higher animals, including humans. [ABSTRACT FROM AUTHOR]

The role of cortisol as a premorbid vulnerability factor for trauma sequelae remains unclear. Furthermore, the onset of long-term endocrine changes in response to first-time trauma as a function of later psychopathology is not clarified yet. Thus the predictive value of pre- and post-traumatic hair cortisol concentrations (HCCs) for psychological trauma sequelae was investigated in response to motor vehicle crash (MVC). A total of N= 62 MVC survivors participated in this study (46 females, mean age (SD): 43.94(12.95)). Subsequent trauma sequelae were measured with a structured clinical interview and self-report questionnaires to evaluate psychological symptoms (pre-MVC and three months post-MVC). Hair strands were taken immediately after MVC and three months post-MVC, reflecting cumulative cortisol secretion over the three-month period before and after the MVC. A total of 22.6% of the participants developed a trauma sequela with an affective disorder (14.5%) and/or anxiety disorder (16.1%). We observed a significant main effect of group and diagnosis × time interaction with an increase of HCC in those individuals who presented a subsequent psychiatric disorder. Regression analyses revealed that post-MVC increased HCC were significantly predictive of higher levels of subsequent depressiveness, and that pre-MVC increased HCC were predictive of higher levels of subsequent avoidance behavior. Our findings demonstrate that individual differences in long-term cortisol secretion in response to a first-time traumatic event (MVC) contribute to subsequent psychopathology. Specifically, higher long-term cortisol secretion before and after first-time MVC was a risk factor for subsequent development of avoidance behavior and depressiveness, respectively. Higher cortisol secretion and stress experience before a motor vehicle crash was a risk factor for subsequent development of psychological symptoms. [ABSTRACT FROM AUTHOR]

Background: In face-to-face (offline) social situations a tendency, or bias, to negatively interpret ambiguous situations is consistently related to social anxiety. Although social interactions increasingly occur over the Internet (online), our understanding of cognitive processes in online social situations and how they relate to social anxiety, social experiences, and behavior, is limited. Methods: In a sample of 324 young people (18–25 years), the current study addressed this gap in two ways: by simultaneously investigating online and offline interpretation bias in relation to social anxiety; and examining the extent to which online interpretation bias predicts peer victimization and avoidance. Results: In line with hypotheses, online and offline interpretation bias each correlated positively with social anxiety; the offline interpretation bias-social anxiety association was stronger. Regression analyses revealed unique associations between online interpretation bias and online peer victimization and avoidance, after controlling for social anxiety and offline interpretation bias. Discussion: Findings suggest that cognitive behavioral interventions for social anxiety could be optimized through eliciting and testing negative social beliefs related to online social settings. Conclusions: The current study's results indicate the importance of studying online interpretation bias to further understand social anxiety in online social environments. [ABSTRACT FROM AUTHOR]

Background: The correlation of unintentional injury mortality to rising temperatures found in several studies could result from changes in behavior that increases exposure to hazards or risk when exposed. Temperature, precipitation and air pollutants may contribute to symptoms and distractions that increase risk or avoidance behavior that reduces risk. This study examines data that allows estimates of the relation of daily maximum temperature, precipitation and ozone pollution to injury mortality risk, each corrected statistically for the correlation with the others. Methods: Daily data on unintentional injury deaths and exposures to temperature, precipitation and ozone in 9 cities in Jiangsu Province, China during 2015–2017 were analyzed using Poisson regression. The regression estimates were adjusted for weekends, holidays, an anomalous difference in death rates in Nanjing, and population size. Results: Non transport injury death risk increased substantially in relation to higher temperatures when temperatures were in the moderate range and even more so at temperatures 35 degrees (C) and higher. Transport deaths were related to increasing deaths when temperatures were low but the correlation reversed at higher temperatures. Deaths were lower on rainy days when temperatures were cool and moderate with the exception of non-transport injuries when temperatures were moderate. Higher ozone concentrations were associated with more deaths except when temperatures were low. Conclusions: The variations in deaths in relation to temperature, precipitation and ozone suggest that people are behaving differently or are in different environments when specific combinations of the predictor variables are prevalent, putting them at greater or less risk. More study of the behaviors and circumstances that result in injury under those conditions is needed. [ABSTRACT FROM AUTHOR]

The effects from rising temperatures, a symptom of climate change, have become a significant concern. This study finds that one additional day with a maximum temperature of 30–32 °C (86–89.6 °F), relative to a day with a temperature of 28–30 °C (82.4–86 °F), decreases the birth rate 9 months later by 0.24%, or 92 babies per month in South Korea. This result is robust to various specifications and samples. This study also found that the impact of the temperature bin did not vary according to the mother's characteristics, including education and age. That is, high temperature has no differential effect on mothers of different backgrounds. Finally, we found no significant temperature effect on birth outcomes, but we cannot rule out that children born 9 months after summer heat are a selected (healthy) group. [ABSTRACT FROM AUTHOR]

In any ecosystem, chaotic situations may arise from equilibrium state for different reasons. To overcome these chaotic situations, sometimes the system itself exhibits some mechanisms of self-adaptability. In this paper, we explore an eco-epidemiological model consisting of three aquatic groups: phytoplankton, zooplankton, and marine free viruses. We assume that the phytoplankton population is infected by external free viruses and zooplankton get affected on consumption of infected phytoplankton; also, the infected phytoplankton do not compete for resources with the susceptible one. In addition, we model a mechanism by which zooplankton recognize and avoid infected phytoplankton, at least when susceptible phytoplankton are present. The zooplankton extinction chance increases on increasing the force of infection or decreasing the intensity of avoidance. Further, when the viral infection triggers chaotic dynamics, high zooplankton avoidance intensity can stabilize again the system. Interestingly, for high avoidance intensity, nutrient enrichment has a destabilizing effect on the system dynamics, which is in line with the paradox of enrichment. Global sensitivity analysis helps to identify the most significant parameters that reduce the infected phytoplankton in the system. Finally, we compare the dynamics of the system by allowing the infected phytoplankton also to share resources with the susceptible phytoplankton. A gradual increase of the virus replication factor turns the system dynamics from chaos to doubling state to limit cycle to stable state and the system finally settles down to the zooplankton-free equilibrium point. Moreover, on increasing the intensity of avoidance, the system shows a transcritical bifurcation from the zooplankton-free equilibrium to the coexistence steady state and remains stable thereafter. [ABSTRACT FROM AUTHOR]

Introduction: Harmful behavior such as smoking may reflect a disturbance in the balance of goal-directed and habitual control. Animal models suggest that habitual control develops after prolonged substance use. In this study, we investigated whether smokers (N = 49) differ from controls (N = 46) in the regulation of goal-directed and habitual behavior. It was also investigated whether individual differences in nicotine dependence levels were associated with habitual responding.Methods: We used two different multistage instrumental learning tasks that consist of an instrumental learning phase, subsequent outcome devaluation, and a testing phase to measure the balance between goal-directed and habitual responding. The testing phases of these tasks occurred after either appetitive versus avoidance instrumental learning. The appetitive versus aversive instrumental learning stages in the two different tasks modeled positive versus negative reinforcement, respectively.Results: Smokers and nonsmoking controls did not differ on habitual versus goal-directed control in either task. Individual differences in nicotine dependence within the group of smokers, however, were positively associated with habitual responding after appetitive instrumental learning. This effect seems to be due to impaired stimulus-outcome learning, thereby hampering goal-directed task performance and tipping the balance to habitual responding.Conclusions: The current finding highlights the importance of individual differences within smokers. For future research, neuroimaging studies are suggested to further unravel the nature of the imbalance between goal-directed versus habitual control in severely dependent smokers by directly measuring activity in the corresponding brain systems.Implications: Goal-directed versus habitual behavior in substance use and addiction is highly debated. This study investigated goal-directed versus habitual control in smokers. The findings suggest that smokers do not differ from controls in goal-directed versus habitual control. Individual differences in nicotine dependence within smokers, however, were positively associated with habitual responding after appetitive instrumental learning. This effect seems to be due to impaired stimulus-outcome learning, thereby hampering goal-directed task performance and tipping the balance to habitual responding. These findings add to the ongoing debate on habitual versus goal-directed control in addiction and emphasize the importance of individual differences within smokers. [ABSTRACT FROM AUTHOR]