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In this manuscript, three novel schemes (Generalized direct algebraic; Improved simple equation and Modified F-expansion methods) are successfully utilized to find the solitary solutions of generalized form of Pochhammer-Chree equation.The concerned wave model has been used in the scrutiny for the propagating of harmonic waves in a cylindrical rod and several problems in fluid mechanics and waves theory in physics. The obtained results have imperative role in the field of the nonlinear science.

Peach fruit and trees are prone to various issues, regarding yield, quality and pest attack. Calcium plays several roles in plant and fruit development. Therefore the current study was conducted to evaluate the response of peach fruit to foliar application. The experiment was laid out in Randomized Complete Block Design with two factors factorial arrangement and three replicates. Calcium chloride was applied at the rate of 0, 1, 2 and 3%. The foliar application of calcium was done at pink bud stage, berry size fruit stage, and then at pit hardening stage of peach. The obtained resulted indicated that foliar application of calcium significantly improved peach fruit quality and yield. The highest fruit weight (142.6 g), yield tree–1 (15.6 kg), ascorbic acid content (6.67 mg‧100 g–1), total soluble solids (11.0°Bx), fruit juice pH (3.98), sugar to acid ratio (45.1), fruit firmness (3.90 kg‧cm–2) and fruit volume (155.6 cm3) was obtained with the application of 3% solution of calcium chloride at pit hardening stage but it significantly reduced the percent titratable acidity (0.3%) and disease incidence (5.8%). It was concluded that 3% calcium chloride applied at the pit hardening stage significantly boosted peach quality and fruit yield.

We present the case of an asymptomatic woman, a chronic heavy smoker, who presented with an incidental lung mass and mediastinal lymphadenopathy. Bronchoscopy with transbronchial biopsy and endobronchial ultrasound-guided transbronchial needle aspiration did not show malignancy. A positron emission tomography/computed tomography scan showed increased uptake with a standardized uptake value of 26.4 in the mediastinal lymph node and an additional hypermetabolic right supraclavicular lymph node. Surgical biopsy of the supraclavicular node revealed non-necrotizing granuloma. Discussion of the clinical dilemma is provided. Keywords: Sarcoidosis, PET CT, Lung mass

Abstract We have employed a modified form of the F-expansion technique on four nonlinear waves models and obtained numerous exact and soliton wave solutions in a different form. New constructed solutions showed the significance of these models. The constructed results have plenty applications in nonlinear research.

In our research, we ascertain abundant novel exact traveling wave solutions of (2 + 1)-dimensional first integro-differential Kadomtsev-Petviashivili hierarchy equation by two new modified mathematical methods namely called generalized direct algebraic and extended simple equation methods with the help of computer package like Mathematica. These exact solutions are expressed in the forms of trigonometric, hyperbolic and rational function solutions which are established by using our eminent methods and also comparing our results to all of the well-known results that are given in the literature. These methods are more easier and having fruitful applications to solve different nonlinear wave problems in nonlinear science. Keywords: First integro-differential KP hierarchy equation, Generalized direct algebraic method, Extended simple equation method

The purpose of this article is to present a framework that could be used to achieve the objective of sustainable rural development in a community which is characterized by high numbers of smallholders, landless peasants, and unskilled or semi-skilled labor ultimately leading to low productivity and high rates of poverty. The study presents a design inspired by “Saemaul Undong” (New Village Movement) of South Korea. The proposed model is based on proposing a four-tier approach for the working of the village-level cooperatives which will be self-reliant through a network connection to the national and international markets. Existing studies and surveys in Punjab province of Pakistan have established that rural areas are often lacking essential facilities that affect the abilities of these areas to retain skilled manpower thus leading to resource drain and negatively impacting the agricultural productivity. The proposed Village-City Model, “VCM,” was designed to strengthen the local infrastructure and built interest-based cooperatives to develop an environment which can sustain the benefits of higher productivity and translate these into better livelihoods. It is proposed that farmer-centered cooperatives with appropriate institutional arrangements could result in developing village-based cities where skilled manpower can exert to in better resource use efficiency, access to market coupled with rural finance schemes to enhance resource base and access to technology. The cooperatives experience is considered as a bitter experience in Pakistan. However, the analysis of failures of cooperatives in Pakistan revealed many bottlenecks which have been addressed through indigenization of Saemaul Undong.

Adolescence is a very crucial stage of development. In order to determine the effect of perceived parenting styles on disruptive behavior, this study was planned to conduct among adolescents. The sample consisted of 120 adolescents who were taken from Multan City by using Purposive sampling technique. Parenting styles scale developed by Jody Powell (1990) and Beck Disruptive Behavior Inventory developed by Beck (2005) were used to assess perceived parenting styles and disruptive behavior respectively. The results indicated that there was a negative correlation between parenting styles and disruptive behavior. Results also showing the significant difference among male and female adolescence disruptive behavior and also defined that there is no significant difference in disruptive behavior among rural and urban adolescence. More studies should be conducted on this issue because it is important to enhance the positive child rearing practices in order to avoid problems in later life.

Abstract In this manuscript, we utilize the algorithm of (G′/G) $(G'/G)$ expansion method to construct new solutions of three important models, the Ablowitz–Kaup–Newell–Segur water wave equation, the (2+1) $(2 + 1)$-dimensional Boussinesq equation, and the (3+1) $(3+1)$-dimensional Yu–Toda–Sasa–Fukuyama equation, having numerous application in plasma physics, fluid dynamics, and optical fibers. Some new types of traveling wave solutions are acquired, which have not been obtained previously by using this our new technique. The achieved solutions appear with all necessary constraint conditions, which are compulsory for them to exist. The constructed new solutions have vital applications in applied sciences. To understand the physical phenomena of these models, we have also presented graphically movements of the obtained results. It is shown that the our technique provides a more powerful mathematical tool for constructing exact traveling wave solutions for many other nonlinear waves models in mathematics and physics.

The present study investigates the impact of foreign remittance on agricultural development in Pakistan, from different regions of the world. Segregated time series data of remittance, agricultural GDP, primary school enrollment and gross fixed capital formation in agriculture sector were taken for the period 1972 to 2012. Co-integration technique was employed to analyze the longrun impact of these variables on agricultural GDP. The coefficients of remittance from Kingdom of Saudi Arabia, UAE, United Kingdom and other Gulf and European countries were found to be significant and positive in the long-run, but it was non-significant in the short-run. The effect of remittance from advanced countries as USA, Canada and Australia showed a negative and significant effect on agricultural GDP in the long-run but it was non-significant in the short-run. The variables of primary school enrollment and gross fixed capital formation were also significantly and positively associated with agricultural GDP growth in the long-run. The findings reveal that remittance play a vital role to meet needs of the agricultural sector. This study suggests that government should devise a policy to encourage migrant’s households in rural Pakistan and use remittance in productive activities. The results also suggest that policies should also be devised to promote primary education and increase the fixed-capital formation in agriculture sector.

In this current work, we employ novel methods to find the exact travelling wave solutions of Modified Liouville equation and the Symmetric Regularized Long Wave equation, which are called extended simple equation and exp(-Ψ(ξ))-expansion methods. By assigning the different values to the parameters, different types of the solitary wave solutions are derived from the exact traveling wave solutions, which shows the efficiency and precision of our methods. Some solutions have been represented by graphical. The obtained results have several applications in physical science. Keywords: Extended simple equation method, Exp(-Ψ(ξ))-expansion method, Modified Liouville equation, The Symmetric Regularized Long Wave equation, Traveling wave solutions, Solitary wave solutions

The Equal-Width and Modified Equal-Width equations are used as a model in partial differential equations for the simulation of one-dimensional wave transmission in nonlinear media with dispersion processes. In this article we have employed extend simple equation method and the exp(−varphi(ξ)) expansion method to construct the exact traveling wave solutions of equal width and modified equal width equations. The obtained results are novel and have numerous applications in current areas of research in mathematical physics. It is exposed that our method, with the help of symbolic computation, provides a effective and powerful mathematical tool for solving different kind nonlinear wave problems. Keywords: Equal-Width equation (EWE), Modified Equal-Width equation (MEWE), Extended simple equation method, Exp(−φ(ξ)) expansion method, Exact solutions, Solitary wave solutions

Abstract Background The residents of remote areas mostly depend on folk knowledge of medicinal plants to cure different ailments. The present study was carried out to document and analyze traditional use regarding the medicinal plants among communities residing in Koh-e-Safaid Range northern Pakistani-Afghan border. Methods A purposive sampling method was used for the selection of informants, and information regarding the ethnomedicinal use of plants was collected through semi-structured interviews. The collected data was analyzed through quantitative indices viz. relative frequency citation, use value, and family use value. The conservation status of medicinal plants was enumerated with the help of International Union for Conservation of Nature Red List Categories and Criteria (2001). Plant samples were deposited at the Herbarium of Botany Department, University of Peshawar for future reference. Results One hundred eight informants including 72 male and 36 female were interviewed. The informants provided information about 92 plants species used in the treatment of 53 ailments. The informant reported maximum number of species used for the treatment of diabetes (16 species), followed by carminatives (12 species), laxatives (11 species), antiseptics (11 species), for cough (10 species), to treat hepatitis (9 species), for curing diarrhea (7 species), and to cure ulcers (7 species), etc. Decoction (37 species, i.e., 40%) was the common method of recipe preparation. Most familiar medicinal plants were Withania coagulans, Caralluma tuberculata, and Artemisia absinthium with relative frequency (0.96), (0.90), and (0.86), respectively. The relative importance of Withania coagulans was highest (1.63) followed by Artemisia absinthium (1.34), Caralluma tuberculata (1.20), Cassia fistula (1.10), Thymus linearis (1.06), etc. This study allows identification of novel uses of plants. Abies pindrow, Artemisia scoparia, Nannorrhops ritchiana, Salvia reflexa, and Vincetoxicum cardiostephanum have not been reported previously for their medicinal importance. The study also highlights many medicinal plants used to treat chronic metabolic conditions in patients with diabetes. Conclusions The folk knowledge of medicinal plants species of Koh-e-Safaid Range was unexplored. We, for the first time, conducted this quantitative study in the area to document medicinal plants uses, to preserve traditional knowledge, and also to motivate the local residents against the vanishing wealth of traditional knowledge of medicinal flora. The vast use of medicinal plants reported shows the significance of traditional herbal preparations among tribal people of the area for their health care. Knowledge about the medicinal use of plants is rapidly disappearing in the area as a new generation is unwilling to take interest in medicinal plant use, and the knowledgeable persons keep their knowledge a secret. Thus, the indigenous use of plants needs conservational strategies and further investigation for better utilization of natural resources.

In current era of technology, information acquisition from images and videos become most important task due to the rapid development of data mining and machine learning.The information can be either textual, visual, or combination of these. Text appearing in images or videos is a significant source of information and plays a vital role to perceive it. Developing a unified method to detect the text is hard, as textual properties (i.e. font, size, color, illumination, orientation, etc.) may vary with the complex background. So far, multimedia and computer vision community unable yet to standardize any ideal approach to extract the text smoothly. In this paper, a novel method is proposed to detect and localize artificial Urdu text in individual video frames. Firstly, Sobel and Canny edge detection operators are applied to input frame and are merged with MSER (Maximally Stable Extremal Region) detected regions. Next, geometric constraints are applied to eliminate obvious non-text regions with large and small variations. Further refining of non-text regions is achieved by stroke width transform. SVM (Support Vector Machine) classifier is trained to classify text and non-text objects. Finally, bounding boxes are used to localize the text.Experimental results show that the proposed method is robust and efficient than state-of-the-art methods.

The present research was on the prevalence of marital conflicts among women having postpartum depression and from general population. The sample was of 100 women, including 50 women having postpartum depression and 50 from general population. The data was collected after one week of child birth. The hypothesis was “the marital conflicts will be higher in women with postpartum depression than women from general population”. The hypothesis was tested by using chi-square test, highly significant results revealed that postpartum depression negatively effect the marital relation. Similarly, women with postpartum depression revealed difficulty in understanding themselves and they blamed themselves comparing them with women without postpartum depression. Women with postpartum depression blamed themselves when things went wrong and created troubles for themselves.

The study investigated the relationship between motivation for learning and motivation for reading among university students. A convenient sample of N=300 male and female students was drawn from Punjab University Lahore, Pakistan with age range of 18 to 23 years. Two questionnaires, Motivation for Reading and Motivated strategies for learning were administered on the sample. Results indicates that female students were significantly higher on both, motivation for learning and motivation for reading as compared to male students. Correlational analysis revealed a significant and positive relationship between motivation for learning and motivation for reading. Finally, linear regression analysis revealed that reading motivation is a significantly predictor of learning motivation.

The aim of this work is to build novel analytical wave solutions of the nonlinear space-time fractional (2+1)-dimensional breaking soliton equations, with regards to the modified Riemann–Liouville derivative, by employing mathematical schemes, namely, the improved simple equation and modified F-expansion methods. We used the fractional complex transformation of the concern fractional differential equation to convert it for the solvable integer order differential equation. After the successful implementation of the presented methods, a comprehensive class of novel and broad-ranging exact and solitary travelling wave solutions were discovered, in terms of trigonometric, rational and hyperbolic functions. Hence, the present methods are reliable and efficient for solving nonlinear fractional problems in mathematics physics.

The authors wish to make the following correction to their paper published in Genes [...]

In this research paper a multi-digit Sindhi handwritten numerals recognition system using SOM Neural Network is presented. Handwritten digits recognition is one of the challenging tasks and a lot of research is being carried out since many years. A remarkable work has been done for recognition of isolated handwritten characters as well as digits in many languages like English, Arabic, Devanagari, Chinese, Urdu and Pashto. However, the literature reviewed does not show any remarkable work done for Sindhi numerals recognition. The recognition of Sindhi digits is a difficult task due to the various writing styles and different font sizes. Therefore, SOM (Self-Organizing Map), a NN (Neural Network) method is used which can recognize digits with various writing styles and different font sizes. Only one sample is required to train the network for each pair of multi-digit numerals. A database consisting of 4000 samples of multi-digits consisting only two digits from 10-50 and other matching numerals have been collected by 50 users and the experimental results of proposed method show that an accuracy of 86.89% is achieved.

Degradation of silicon rubber due to heat and humidity affect its performance in outdoor applications. To analyze the effects of high temperature and humidity on room temperature vulcanized (RTV) silicone rubber (SiR) and its composites, this study was performed. Five different sample compositions including neat silicone rubber (nSiR), microcomposites (15 wt% silica(SMC 15% SiO2) and 15 wt% ATH(SMC 15% ATH), nanocomposite (2.5 wt% silica(SNC 2.5% SiO2) and hybrid composite (10 wt% micro alumina trihydrate with 2 wt% nano silica(SMNC 10% ATH 2% SiO2) were prepared and subjected to 70 ˚C temperature and 80% relative humidity in an environmental chamber for 120 h. Contact angle, optical microscopy and Fourier transform infrared (FTIR) spectroscopy were employed to analyze the recovery properties before and after applying stresses. Different trends of degradation and recovery were observed for different concentrations of composites. Addition of fillers improved the overall performance of composites and SMC 15% ATH composite performed better than other composites. For high temperature and humidity, the ATH-based microcomposite was recommended over silica due to its superior thermal retardation properties of ATH. It has been proved that ATH filler is able to withstand high temperature and humidity.

The emergence of micro and nano-based inorganic oxide fillers with optimal filler-loadings further enhances the required insulation characteristics of neat epoxy. During manufacturing and service application, insulators and dielectrics face mechanical stresses which may alter their basic characteristics. Keeping this in mind, the facts’ influence of mechanical stresses and fillers on dielectric properties of polymeric insulators of two epoxy/silica composites were fabricated and thoroughly analyzed for dielectric characteristics under ramped mechanical compressions relative to the unfilled sample. Before compression, epoxy nanocomposites exhibited responses having an average dielectric constant of 7.68 with an average dissipation factor of 0.18. After each compression, dielectric properties of all samples were analyzed. The dissipation factor and the dielectric constant trends of each sample are plotted against a suitable frequency range. It was observed that after the successive compressions up to 25 MPa, the dielectric properties of epoxy micro-silica composites were highly affected, having an average final dielectric constant of 9.65 times that of the uncompressed sample and a dissipation factor of 2.2 times that of the uncompressed sample, and these were recorded.

Water is the most important resource; it is utilized largely in agricultural production and is fundamental to ensuring global food security. This study aims to assess sustainable water management interventions and their impact on the farm economy. To increase water productivity, the most important adaptations that have been proposed are high-efficiency irrigation systems, drought-resistant varieties, the substitution of water-intensive crops with less water-demanding crops, the mulching of soil, zero tillage, and all on-farm operations that can save water, especially ground water. The recent analysis utilized farm survey data from 469 representative farmers along with secondary statistics. The data were collected via a multi-stage sampling technique to ensure the availability of representative farm populations based on a comprehensive site selection criterion. The TOA-MD model estimates the adoption rate of a proposed adaptation based on net farm returns. The impact of high-efficiency irrigation systems and the substitution of high delta crops for low delta crops had a positive impact on net farm returns and per capita income, and a negative impact on farm poverty in the study area. It is recommended that policymakers consult farmer representatives about agricultural and water-related issues so that all the policies can be implemented properly.

Impaired skeletal muscle growth in utero can result in reduced birth weight and poor carcass quality in pigs. Recently, we showed the role of microRNAs (miRNAs) and their target genes in prenatal skeletal muscle development and pathogenesis of intrauterine growth restriction (IUGR). In this study, we performed an integrative miRNA-mRNA transcriptomic analysis in longissimus dorsi muscle (LDM) of pig fetuses at 63 days post conception (dpc) to identify miRNAs and genes correlated to fetal weight. We found 13 miRNAs in LDM significantly correlated to fetal weight, including miR-140, miR-186, miR-101, miR-15, miR-24, miR-29, miR-449, miR-27, miR-142, miR-99, miR-181, miR-199, and miR-210. The expression of these miRNAs decreased with an increase in fetal weight. We also identified 1315 genes significantly correlated to fetal weight at 63 dpc, of which 135 genes were negatively correlated as well as identified as potential targets of the above-listed 13 miRNAs. These miRNAs and their target genes enriched pathways and biological processes important for fetal growth, development, and metabolism. These results indicate that the transcriptomic profile of skeletal muscle can be used to predict fetal weight, and miRNAs correlated to fetal weight can serve as potential biomarkers of prenatal fetal health and growth.

Internet of Things (IoT) performs a vital role in providing connectivity between computing devices, processes, and things. It significantly increases the communication facilities and giving up-to-date information to distributed networks. On the other hand, the techniques of artificial intelligence offer numerous and valuable services in emerging fields. An IoT-based healthcare solution facilitates patients, hospitals, and professionals to observe real-time and critical data. In the literature, most of the solution suffers from data intermission, high ethical standards, and trustworthiness communication. Moreover, network interruption with recurrent expose of sensitive and personal health data decreases the reliance on network systems. Therefore, this paper intends to propose an IoT solution for AI-enabled privacy-preserving with big data transferring using blockchain. Firstly, the proposed algorithm uses a graph-modeling to develop a scalable and reliable system for gathering and transmitting data. In addition, it extracts the subset of nodes using the artificial intelligence approach and achieves efficient services for the healthcare system. Secondly, symmetric-based digital certificates are utilized to offer authentic and confidential transmission with communication resources using blockchain. The proposed algorithm is explored with existing solutions through multiple simulations and proved improvement in terms of realistic parameters.

Deficiency of the placental hormone chorionic somatomammotropin (CSH) can lead to the development of intrauterine growth restriction (IUGR). To gain insight into the physiological consequences of CSH RNA interference (RNAi), the trophectoderm of hatched blastocysts (nine days of gestational age; dGA) was infected with a lentivirus expressing either a scrambled control or CSH-specific shRNA, prior to transfer into synchronized recipient sheep. At 90 dGA, umbilical hemodynamics and fetal measurements were assessed by Doppler ultrasonography. At 120 dGA, pregnancies were fitted with vascular catheters to undergo steady-state metabolic studies with the 3H2O transplacental diffusion technique at 130 dGA. Nutrient uptake rates were determined and tissues were subsequently harvested at necropsy. CSH RNAi reduced (p ≤ 0.05) both fetal and uterine weights as well as umbilical blood flow (mL/min). This ultimately resulted in reduced (p ≤ 0.01) umbilical IGF1 concentrations, as well as reduced umbilical nutrient uptakes (p ≤ 0.05) in CSH RNAi pregnancies. CSH RNAi also reduced (p ≤ 0.05) uterine nutrient uptakes as well as uteroplacental glucose utilization. These data suggest that CSH is necessary to facilitate adequate blood flow for the uptake of oxygen, oxidative substrates, and hormones essential to support fetal and uterine growth.

Silicone rubber is a promising insulating material that has been performing well for different insulating and dielectric applications. However, in outdoor applications, environmental stresses cause structural and surface degradations that diminish its insulating properties. This effect of degradation can be reduced with the addition of a suitable filler to the polymer chains. For the investigation of structural changes and hydrophobicity four different systems were fabricated, including neat silicone rubber, a micro composite (with 15% micro-silica filler), and nanocomposites (with 2.5% and 5% nanosilica filler) by subjecting them to various hydrothermal conditions. In general, remarkable results were obtained by the addition of fillers. However, nanocomposites showed the best resistance against the applied stresses. In comparison to neat silicone rubber, the stability of the structure and hydrophobic behavior was better for micro-silica, which was further enhanced in the case of nanocomposites. The inclusion of 5% nanosilica showed the best results before and after applying aging conditions.

The current coronavirus disease 2019 (COVID-19) outbreak is considered as one of the biggest public health challenges and medical emergencies of the century. A global health emergency demands an urgent development of rapid diagnostic tools and advanced therapeutics for the mitigation of COVID-19. To cope with the current crisis, nanotechnology offers a number of approaches based on abundance and versatile functioning. Despite major developments in early diagnostics and control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is still a need to find effective nanomaterials with low cost, high stability and easy use. Nanozymes are nanomaterials with innate enzyme-like characteristics and exhibit great potential for various biomedical applications such as disease diagnosis and anti-viral agents. Overall the potential and contribution of nanozymes in the fight against SARS-CoV-2 infection i.e., rapid detection, inhibition of the virus at various stages, and effective vaccine development strategies, is not fully explored. This paper discusses the utility and potential of nanozymes from the perspective of COVID-19. Moreover, future research directions and potential applications of nanozymes are highlighted to overcome the challenges related to early diagnosis and therapeutics development for the SARS-CoV-2. We anticipate the current perspective will play an effective role in the existing response to the COVID-19 crisis.

Intrauterine growth restriction (IUGR) occurs in 15–20% of pig neonates and poses huge economic losses to the pig industry. IUGR piglets have reduced skeletal muscle growth, which may persist after birth. Prenatal muscle growth is regulated by complex molecular pathways that are not well understood. MicroRNAs (miRNAs) have emerged as the main regulators of vital pathways and biological processes in the body. This study was designed to identify miRNA–mRNA networks regulating prenatal skeletal muscle development in pigs. We performed an integrative miRNA–mRNA transcriptomic analysis in longissimus dorsi muscle from IUGR fetuses and appropriate for gestational age (AGA) fetuses at 63 days post conception. Our data showed that 47 miRNAs and 3257 mRNAs were significantly upregulated, and six miRNAs and 477 mRNAs were significantly downregulated in IUGR compared to AGA fetuses. Moreover, 47 upregulated miRNAs were negatively correlated and can potentially target 326 downregulated genes, whereas six downregulated miRNAs were negatively correlated and can potentially target 1291 upregulated genes. These miRNA–mRNA networks showed enrichment in biological processes and pathways critical for fetal growth, development, and metabolism. The miRNA–mRNA networks identified in this study can potentially serve as indicators of prenatal fetal growth and development as well as postnatal carcass quality.

The scope of silicone rubber (SiR) is confined due to the deprivation of its dielectric propertiesupon exposure to various ambient stresses. The aim of this research is to develop silicone rubber-based composites by employing inorganic oxide fillers for improved dielectric and high voltage insulation properties for widening its scope in the field of electrical appliances. This study reports the preparation of different composites of silicone rubber with varying concentrations of micro and nano-silica fillers. The dielectric propertytrends of these as-prepared neat and impregnated samples were examined via an indigenously developed weathering chamber capable of applying multiple stresses of acid rain, heat, humidity, UVA radiation, and salt fog. Dielectric constant values were measured before and after applying stresses. Upon applying stresses, a periodic decline in dielectric constant was observed. Improved dielectric properties were obtained by adding micro and nano-silica as fillers. A nano silica-incorporated silicone rubber product exhibited good potential for dual applications as dielectric and high voltage insulation.

Self-efficacy is the person’s complete belief on his or her abilities that he or she succeeds in a specific situation. Different activities covered by Personal growth which develop aptitudes, improve identity and boost our quality of life. The present study was intended to explore the impact of self-efficacy on personal growth among distance learners. It was deeply focused on new emerging trend of distance learning in Pakistan. Data was collected through simple random sampling from participants (males and females) aged 20-32. For the purpose of data collection two scales were used in this research i.e., Personal Growth Initiative Scale (PGIS -II; Robitschek, Ashton, Spering, Geiger, Byers, Schotts, & Thoen, 2012) and Self Efficacy scale (Schwarzer &Jerusalem,2000). Analysis of the data revealed that there is a significant impact of self-efficacy on personal growth. No gender differences were found on personal growth Initiative and self-efficacy. The findings conclude that the present study will be fruitful in uplifting the society’s emerging trend of distance learning and to provide quality education to the door step of every member of the society.

Abstract A nanowire-like WSe2-graphene catalyst was prepared via ultra-sonication and was tested in terms of the photocatalytic reduction of CO2 into CH3OH under irradiation with UV/visible light. The prepared nano-composite was further characterized via XRD, SEM, TEM, Raman and XPS. The photocurrent analysis was further tested for its photocatalytic reduction of CO2 using gas chromatography (GCMS-QP2010 SE). To further improve the the photo-catalytic efficiency, a sacrificial agent (Na2S/Na2SO3) was added to the WSe2-graphene nanocomposite and was found to improve the photo-catalytic efficiency, with the methanol yield reaching 5.0278 µmol g−1h−1. Our present work provides a convenient way to prepare nanomaterials various morphologies that have future applications for environmental remediation.

There is a debate going on in the present literature that how narcissism predicts several behaviors on social networking sites but the search for potential moderators of that relationship was not given much attention. A survey that assesses narcissism, time spent on TV and self-promoting behavior on Facebook was conducted with 151 undergraduate and post graduate students. Our finding indicates that narcissism and time spent on TV has significant positive relationship with self-promoting behavior on Facebook. The relationship between narcissism and self- promoting behavior is found to be significantly moderated by time spent on TV. The findings are discussed in the context of learning self-enhancing through exposure to TV programs and imitating that behavior for self-regulation by narcissistic individuals through social media.

TiO2 thin film is deposited on glass substrate by sol-gel dip coating technique. After deposition, films were irradiated by continuous wave (CW) diode laser at an angle of 45°. XRD shows both the anatase and brookite phases of TiO2. Nano particles of regular and control sizes are appeared in SEM micrographs. Therefore, shape and size of nano particles can be control by using Laser irradiation. The average sheet resistivity of TiO2 thin film irradiated by 0, 2, 4 and 6 min are 6.72 × 105, 5.32 × 105, 3.44 × 105 and 4.95 × 105 (ohm-m) respectively, according to four point probe. Keywords: TiO2, Diode laser, XRD, SEM

Here inside script, novel technique extended simple equation is employed to establish servable exact traveling wave solutions in the form of hyperbolic, trigonometric and expontional via our three selective models, which illustrated the validity of the method. Our outcomes disclose that new technique is very active and straightforward and obtained results having numerous applications to solve different types of nonlinear wave problems in applied sciences. Keywords: 3-D Zakharov-Kuznetsov-Burgers (ZKB) equation, (3+1)-D Yu-Toda-Sasa-Fukuyama equation, Benney-Luke wave equation, Extended simple equation (ESE) method, Exact and solitary wave solutions

Objective. Asthma education programs have been shown to be effective in decreasing health care utilization and improving disease control and management. However, there are few studies evaluating the outcomes of group asthma education. The aim of this study was to assess the impact of an outpatient adult group asthma education program in an inner-city-based hospital caring for an underserved population. Methods. We conducted a pre- and poststudy of all patients with asthma who participated in two structured group asthma education sessions led by a respiratory therapist, clinical pharmacist, and pulmonologist. The study period (January 2016 to April 2018) included the year before group education and the year after education. The primary outcomes were the number of patients requiring emergency room visits and hospital admission. The secondary outcomes included asthma control as assessed by Asthma Control Test scores, use of systemic corticosteroids, and change in test scores postintervention. Results. Eighty-eight patients received group education during the study period; 82 attended 2/2 sessions, and 6 attended 1/2 sessions. The study population was largely Hispanic (73%) or African American (25%) and had a mean age of 58 years. Most had moderate (57%) or severe (25%) persistent asthma. Significantly, fewer patients required emergency room visits in the postintervention period than in the preintervention period (20 visits vs. 42 visits, p=0.0002). Group education was also associated with increased asthma control (p=0.0043), decreased use of systemic corticosteroids (p=0.0005), and higher postintervention test scores (p=0.0001). Conclusions. Group asthma education provided by a multidisciplinary team in an inner-city hospital clinic caring for underserved and minority populations is feasible and may decrease utilization of health care resources when patients are educated and empowered to participate in their asthma management.

BACKGROUND Hospital wastewaters may contain antibiotic resistant bacteria such as Escherichia coli. These E. coli harbor integron genes that are responsible for antibiotic resistance. The purpose of the current study was to evaluate the frequency of class 1 and 2 integrons in environmental antibiotic resistant E. coli strains isolated from the hospital wastewaters in Tehran, Iran. METHODS As a descriptive cross-sectional study, this research was performed from April to September 2015 on hospital wastewaters in Tehran. Bacterial isolation and identification was performed by standard biochemical and bacteriological procedures. Susceptibility testing was done by employing the disk diffusion method using different antibiotics. Total DNAs were extracted to evaluate the presence of class 1 and 2 integrons by using the polymerase chain reaction (PCR) method with specific primers. RESULTS Fifty E. coli strains were isolated and identified from the wastewaters of 25 hospitals in Tehran. The phenotype results showed that 46 isolates (92%) were resistant to at least one antibiotic and 27 isolates (54%) were multidrug resistant. PCR showed that 35 (70%) and 20 (40%) of the isolates had class 1 and 2 integrons respectively and 14 isolates (28%) had both class 1 and class 2 integrons. CONCLUSION This study has shown a considerable presence of class 1 and class 2 integrons in E. coli strains isolated from hospital wastewaters in Tehran. Proper antibiotics prescription and appropriate hospital wastewater treatment can prevent resistance genes in E. coli from circulating in the environment.

The Tibetan cashmere goat is one of the main goat breeds used by people living in the plateau. It exhibits the distinct phenotypic characteristics observed in lowland goats, allowing them to adapt to the challenging conditions at high altitudes. It provides an ideal model for understanding the genetic mechanisms underlying high-altitude adaptation and hypoxia-related diseases. Our previous exome sequencing of five Chinese cashmere breeds revealed a candidate gene, DSG3 (Desmoglein 3), responsible for the high-altitude adaptation of the Tibetan goat. However, the whole DSG3 gene (44 kbp) consisting of 16 exons in the goat genome was not entirely covered by the exome sequencing. In this study, we resequenced all the 16 exons of the DSG3 gene in ten Chinese native goat populations. Twenty-seven SNP variants were found between the lowland and highland goat populations. The genetic distance (FST) of significant SNPs between the lowland and highland populations ranged from 0.42 to 0.58. By using correlation coefficient analysis, linkage disequilibrium, and haplotype network construction, we found three non-synonymous SNPs (R597E, T595I, and G572S) in exon 5 and two synonymous SNPs in exons 8 and 16 in DSG3. These mutations significantly segregated high- and low-altitude goats in two clusters, indicating the contribution of DSG3 to the high-altitude hypoxia adaptation in the Tibetan goat.

Pregnancy complications are a major cause of fetal and maternal morbidity and mortality in humans. The majority of pregnancy complications initiate due to abnormal placental development and function. During the last decade, the role of microRNAs (miRNAs) in regulating placental and fetal development has become evident. Dysregulation of miRNAs in the placenta not only affects placental development and function, but these miRNAs can also be exported to both maternal and fetal compartments and affect maternal physiology and fetal growth and development. Due to their differential expression in the placenta and maternal circulation during pregnancy complications, miRNAs can be used as diagnostic biomarkers. However, the differential expression of a miRNA in the placenta may not always be reflected in maternal circulation, which makes it difficult to find a reliable biomarker for placental dysfunction. In this review, we provide an overview of differentially expressed miRNAs in the placenta and/or maternal circulation during preeclampsia (PE) and intrauterine growth restriction (IUGR), which can potentially serve as biomarkers for prediction or diagnosis of pregnancy complications. Using different bioinformatics tools, we also identified potential target genes of miRNAs associated with PE and IUGR, and the role of miRNA-mRNA networks in the regulation of important signaling pathways and biological processes.

The extensive research in the field of multimodal biometrics by the research community and the advent of modern technology has compelled the use of multimodal biometrics in real life applications. Biometric systems that are based on a single modality have many constraints like noise, less universality, intra class variations and spoof attacks. On the other hand, multimodal biometric systems are gaining greater attention because of their high accuracy, increased reliability and enhanced security. This research paper proposes and develops a Convolutional Neural Network (CNN) based model for the feature level fusion of fingerprint and online signature. Two types of feature level fusion schemes for the fingerprint and online signature have been implemented in this paper. The first scheme named early fusion combines the features of fingerprints and online signatures before the fully connected layers, while the second fusion scheme named late fusion combines the features after fully connected layers. To train and test the proposed model, a new multimodal dataset consisting of 1400 samples of fingerprints and 1400 samples of online signatures from 280 subjects was collected. To train the proposed model more effectively, the size of the training data was further increased using augmentation techniques. The experimental results show an accuracy of 99.10% achieved with early feature fusion scheme, while 98.35% was achieved with late feature fusion scheme.

Epoxy and its composites have shown remarkable properties to be used for outdoor high voltage insulation applications. However, outdoor environment that contains UV-A radiations deteriorates the organic structure of epoxy-based insulators. To analyze the surface degradation and chemical changes in structure due to UV radiations, neat epoxy (NEPOX), 15 wt.% epoxy microcomposite (EMC 15) and 5 wt.% epoxy nanocomposite (ENC 5) were prepared and subjected to a specially fabricated UV chamber under accelerated conditions. The samples were analyzed with visual inspection, STRI hydrophobicity classification, and Scanning Electron Microscopy (SEM) and Fourier Transform Infrared (FTIR) spectroscopy. The analyses confirmed the pattern of gradual degradation of surface structure due to the appearance of ester and carbonyl groups due to oxidation of hydrocarbon chains. FTIR peaks of C=O stretching at ∼1725.52 increased by 157.44%, 75.86% and 33.33% for NEPOX, EMC 15 and ENC, respectively. This shows that ENC-5 expressed better resistance against surface oxidation as compared to EMC 15 and NEPOX. Addition of fillers enhanced the chain intactness and nano filler performed even better due to greater surface area and surface energy.

Mammalian reproductive health affects the entire reproductive cycle starting with the ovarian function through implantation and fetal growth. Various environmental and physiological factors contribute to disturbed reproductive health status leading to infertility problems in mammalian species. In the last couple of decades a significant number of studies have been conducted to investigate the transcriptome of reproductive tissues and organs in relation to the various reproductive health issues including endometritis, polycystic ovarian syndrome (PCOS), intrauterine growth restriction (IUGR), preeclampsia, and various age-associated reproductive disorders. Among others, the post-transcriptional regulation of genes by small noncoding miRNAs contributes to the observed transcriptome dysregulation associated with reproductive pathophysiological conditions. MicroRNAs as a class of non-coding RNAs are also known to be involved in various pathophysiological conditions either in cellular cytoplasm or they can be released to the extracellular fluid via membrane-bounded extracellular vesicles and proteins. The present review summarizes the cellular and extracellular miRNAs and their association with the etiology of major reproductive pathologies including PCOS, endometritis, IUGR and age-associated disorders in various mammalian species.

The present study described the extracellular synthesis of silver nanoparticles (AgNPs) using environmental bacterial isolate Citrobacter spp. MS5 culture supernatant. To our best knowledge, no previous study reported the biosynthesis of AgNPs using this bacterial isolate. The biosynthesized AgNPs were characterized using different techniques like UV-Vis spectroscopy, fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) equipped with energy dispersive X-ray (EDX). The analysis of UV-Vis spectra revealed absorption maxima at 415 nm due to surface plasmon resonance (SPR) indicated the formation of AgNPs and FTIR spectrum confirmed the participation of proteins molecule in AgNPs synthesis. XRD and EDX spectrum confirmed the metallic and crystalline nature of AgNPs. TEM and SEM showed spherical nanoparticles with a size range of 5–15 nm. The biosynthesized AgNPs showed effective independent as well as enhanced combined antibacterial activity against extended spectrum β-lactamase (ESBL) producing multidrug resistant Gram-negative bacteria. Further, effective antifungal activity of AgNPs was observed towards pathogenic Candida spp. The present study provides evidence for eco-friendly biosynthesis of well-characterized AgNPs and their potential antibacterial as well as antifungal activity.

Placental disorders are a major cause of pregnancy loss in humans, and 40–60% of embryos are lost between fertilization and birth. Successful embryo implantation and placental development requires rapid proliferation, invasion, and migration of trophoblast cells. In recent years, microRNAs (miRNAs) have emerged as key regulators of molecular pathways involved in trophoblast function. A miRNA binds its target mRNA in the 3ʹ-untranslated region (3ʹ-UTR), causing its degradation or translational repression. Lethal-7 (let-7) miRNAs induce cell differentiation and reduce cell proliferation by targeting proliferation-associated genes. The oncoprotein LIN28 represses the biogenesis of mature let-7 miRNAs. Proliferating cells have high LIN28 and low let-7 miRNAs, whereas differentiating cells have low LIN28 and high let-7 miRNAs. In placenta, low LIN28 and high let-7 miRNAs can lead to reduced proliferation of trophoblast cells, resulting in abnormal placental development. In trophoblast cells, let-7 miRNAs reduce the expression of proliferation factors either directly by binding their mRNA in 3ʹ-UTR or indirectly by targeting the AT-rich interaction domain (ARID)3B complex, a transcription-activating complex comprised of ARID3A, ARID3B, and histone demethylase 4C (KDM4C). In this review, we discuss regulation of trophoblast function by miRNAs, focusing on the role of LIN28-let-7-ARID3B pathway in placental development.

LIN28 inhibits let-7 miRNA maturation which prevents cell differentiation and promotes proliferation. We hypothesized that the LIN28-let-7 axis regulates proliferation-associated genes in sheep trophectoderm in vivo. Day 9-hatched sheep blastocysts were incubated with lentiviral particles to deliver shRNA targeting LIN28 specifically to trophectoderm cells. At day 16, conceptus elongation was significantly reduced in LIN28A and LIN28B knockdowns. Let-7 miRNAs were significantly increased and IGF2BP1-3, HMGA1, ARID3B, and c-MYC were decreased in trophectoderm from knockdown conceptuses. Ovine trophoblast (OTR) cells derived from day 16 trophectoderm are a useful tool for in vitro experiments. Surprisingly, LIN28 was significantly reduced and let-7 miRNAs increased after only a few passages of OTR cells, suggesting these passaged cells represent a more differentiated phenotype. To create an OTR cell line more similar to day 16 trophectoderm we overexpressed LIN28A and LIN28B, which significantly decreased let-7 miRNAs and increased IGF2BP1-3, HMGA1, ARID3B, and c-MYC compared to control. This is the first study showing the role of the LIN28-let-7 axis in trophoblast proliferation and conceptus elongation in vivo. These results suggest that reduced LIN28 during early placental development can lead to reduced trophoblast proliferation and sheep conceptus elongation at a critical period for successful establishment of pregnancy.

Early diagnosis of mammary gland tumors is a challenging task in animals, especially in unspayed dogs. Hence, this study investigated the role of microsatellite instability (MSI), MMR gene mRNA transcript levels and SNPs of MMR genes in canine mammary gland tumors (CMT). A total of 77 microsatellite (MS) markers in 23 primary CMT were selected from four breeds of dogs. The results revealed that 11 out of 77 MS markers were unstable and showed MSI in all the tumors (at least at one locus), while the other markers were stable. Compared to the other markers, the ABC9TETRA, MEPIA, 9A5, SCNA11 and FJL25 markers showed higher frequencies of instability. All CMT demonstrated MSI, with eight tumors presenting MSI-H. The RT-qPCR results revealed significant upregulation of the mRNA levels of cMSH3, cMLH1, and cPMSI, but downregulation of cMSH2 compared to the levels in the control group. Moreover, single nucleotide polymorphisms (SNPs) were observed in the cMSH2 gene in four exons, i.e., 2, 6, 15, and 16. In conclusion, MSI, overexpression of MMR genes and SNPs in the MMR gene are associated with CMT and could be served as diagnostic biomarkers for CMT in the future.

Epoxy decays its dielectric characteristics and exhibits degradation of main hydrocarbon on exposure to multiple environmental stresses. Inorganic oxides-based epoxy composites have been performingwell in many applications and short-term testing; therefore, evaluation of their dielectric and structural characteristics under extreme weathering conditions may also unleash enhancement in these characteristics. To explore dielectric properties and degradation of main hydrocarbon group, neat epoxy and silica-based epoxy microcomposite (15% micro-silica loading) and nanocomposites (5% nano-silica loading)have been prepared and subjected to acid rain, heat, ultra-violet radiation, salt fog, and humidity in a chamber that was specially fabricated in view ofservice conditions. Interesting results were obtained before and after aging. Enhanced intactness of methylene group was observed in nanocomposite followed by micro composite. Similarly, for epoxy nanocomposites not only higher dielectric constant, lower energy dissipation and conductivity was recorded before application of stresses, but also nanocomposite showed superior sustainability in these properties after aging. In all analyses, microcomposites performed better than neat epoxy but in conductivity the results of both samples were found comparable.