139 results on '"Artemiadis, Artemios"'
Search Results
102. Preliminary evidence for gender effects of levetiracetam monotherapy duration on bone health of patients with epilepsy
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Artemiadis, Artemios K., primary, Lambrinoudaki, Irene, additional, Voskou, Panagiota, additional, Tsivgoulis, Georgios, additional, Safouris, Apostolos, additional, Bougea, Anastasia, additional, Giannopoulos, Sotiris, additional, Gatzonis, Stergios, additional, and Triantafyllou, Nikolaos, additional
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- 2016
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103. A Novel Non-Pharmaceutical Treatment for Patients with Mild Cognitive Impairment
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Darviri, Christina, primary, Zavitsanou, Chrysa, additional, Delikou, Aikaterini, additional, Giotaki, Aikaterini, additional, Artemiadis, Artemios, additional, Terentiou, Aspasia, additional, and Chrousos, George P., additional
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- 2016
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104. Pythagorean Self-Awareness Serves Successfully as a New Cognitive Behavioral-Based Technique in Multiple Sclerosis Physical and Psychosocial Well-Being and Quality of Life
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Darviri, Christina, primary, Zavitsanou, Chrysa, additional, Delikou, Aikaterini, additional, Giotaki, Aikaterini, additional, Artemiadis, Artemios, additional, Anagnostouli, Maria, additional, Varvogli, Liza, additional, Vasdekis, Spyros, additional, and Chrousos, George P., additional
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- 2016
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105. Stress Management and Multiple Sclerosis: A Randomized Controlled Trial
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Artemiadis, Artemios K. Vervainioti, Angeliki A. Alexopoulos, Evangelos C. Rombos, Antonis Anagnostouli, Maria C. Darviri, Christina
- Abstract
There is a well-established adverse reciprocal relationship between stress and multiple sclerosis (MS). However, stress management in these patients has been parsimoniously studied. In this parallel randomized controlled trial, relapsing-remitting MS patients were randomly assigned to undergo either an 8-week stress management program (n 31; relaxation breathing and progressive muscle relaxation, twice a day) or not (n 30). Self-reported validated measures were used to evaluate perceived stress, health locus of control, anxiety, and depression. Daily diaries of MS symptoms were also kept by patients. In patients in the intervention group, perceived stress and symptoms of depression were significantly decreased after 8 weeks of relaxation. Repeated measures analyses showed significant group-by-time interactions for both the number of weekly symptoms and the mean intensity per symptom. No other significant change was reported. We deem that our results should encourage future studies that will incorporate more objective clinical and laboratory outcomes.
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- 2012
106. Clinical and Imaging Correlations of Generalized Hypersynchronous Alpha Activity in Human EEG Recordings, During Alertness
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Katsavos, Serafeim, primary, Artemiadis, Artemios, additional, Tsivgoulis, Georgios, additional, Kararizou, Evangelia, additional, Papadopoulos, Georgios, additional, and Triantafyllou, Nikolaos, additional
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- 2015
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107. Residency Training: Determinants of burnout of neurology trainees in Attica, Greece
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Zis, Panagiotis, primary, Artemiadis, Artemios K., additional, Lykouri, Maria, additional, Xirou, Sophia, additional, Roussopoulou, Andromachi, additional, Papageorgiou, Ermioni, additional, Bakola, Eleni, additional, and Anagnostopoulos, Fotios, additional
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- 2015
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108. Self-esteem is associated with perceived stress in multiple sclerosis patients
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N. Ifantopoulou, Parthena, primary, K. Artemiadis, Artemios, additional, Triantafyllou, Nikolaos, additional, Chrousos, George, additional, Papanastasiou, Ioannis, additional, and Darviri, Christina, additional
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- 2015
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109. Ping-pong Gaze in a Patient with Bilateral Hemispheric Ischemic Stroke: Case Report and Video
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Sotiriou, Kostas, primary, Artemiadis, Artemios K., additional, and Papanastasiou, Ioannis, additional
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- 2015
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110. Apoptosis of Oligodendrocytes and Post-Translational Modifications of Myelin Basic Protein in Multiple Sclerosis: Possible Role for the Early Stages of Multiple Sclerosis
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Artemiadis, Artemios K. Anagnostouli, Maria C.
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Recent studies outline apoptosis of oligodendrocytes (OLDs) as an early event prior to the formation of the demyelinated plaque and post-translational modifications (PTMs) of myelin basic protein as characteristic processes of normal-appearing white matter in multiple sclerosis (MS). We reviewed reports using the following keywords: apoptosis, PTMs, autoimmunity and multiple sclerosis in all possible combinations. Introductory basic scientific information is included for the non-experts. Given the standard and ongoing studies, we raise the hypothesis that, at least in some cases, defective apoptosis of OLDs, early in the course of the disease, and post-translationally modified molecules lead to the activation of immune responses and eventually to autoimmunity. Autoimmune reactions and epitope spreading that take place in the course of the disease might obscure the initial events and leave most investigators blind to etiopathogenesis. Our paper outlines the need for studies at the very early stages of the disease, as well as sequential ones, in order to give us a valuable hint about the clarification of the cause(s) of the different clinical subtypes of MS. Copyright (C) 2010 S. Karger AG, Basel
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- 2010
111. Effect of a stress management program on subjects with neck pain: A pilot randomized controlled trial.
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Metikaridis, Damianos T., Hadjipavlou, Alexander, Artemiadis, Artemios, Chrousos, George P., and Darviri, Christina
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NECK pain treatment ,SALIVA analysis ,BREATHING exercises ,CHI-squared test ,CLINICAL trials ,HYDROCORTISONE ,MUSCLE contraction ,NECK pain ,PROBABILITY theory ,PSYCHOLOGICAL tests ,QUESTIONNAIRES ,RESEARCH evaluation ,STATISTICAL sampling ,SCALE analysis (Psychology) ,SELF-evaluation ,PSYCHOLOGICAL stress ,STRESS management ,VISUALIZATION ,PILOT projects ,STATISTICAL significance ,PAIN measurement ,RANDOMIZED controlled trials ,VISUAL analog scale ,TREATMENT effectiveness ,PRE-tests & post-tests ,DATA analysis software ,FUNCTIONAL assessment ,DESCRIPTIVE statistics ,INFERENTIAL statistics ,MANN Whitney U Test ,PSYCHOLOGY - Abstract
BACKGROUND: Studies have shown that stress is implicated in the cause of neck pain (NP). OBJECTIVES: The purpose of this study is to examine the effect of a simple, zero cost stress management program on patients suffering from NP. METHODS: This study is a parallel-type randomized clinical study. People suffering from chronic non-specific NP were chosen randomly to participate in an eight week duration program of stress management (N = 28) (including diaphragmatic breathing, progressive muscle relaxation) or in a no intervention control condition (N = 25). Self-report measures were used for the evaluation of various variables at the beginning and at the end of the eight-week monitoring period. Descriptive and inferential statistic methods were used for the statistical analysis. RESULTS: At the end of the monitoring period, the intervention group showed a statistically significant reduction of stress and anxiety (p = 0.03, p = 0.01), report of stress related symptoms (p = 0.003), percentage of disability due to NP (p = 0.000) and NP intensity (p = 0.002). At the same time, daily routine satisfaction levels were elevated (p = 0.019). No statistically significant difference was observed in cortisol measurements. CONCLUSIONS: Stress management has positive effects on NP patients. [ABSTRACT FROM AUTHOR]
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- 2017
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112. The Healthy Lifestyle and Personal Control Questionnaire (HLPCQ): a novel tool for assessing self-empowerment through a constellation of daily activities
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Darviri, Christina, primary, Alexopoulos, Evangelos C, additional, Artemiadis, Artemios K, additional, Tigani, Xanthi, additional, Kraniotou, Christina, additional, Darvyri, Panagiota, additional, and Chrousos, George P, additional
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- 2014
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113. Auditory event-related potentials (P300) and mesial temporal sclerosis in temporal lobe epilepsy patients
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Artemiadis, Artemios K., additional, Fili, Maria, additional, Papadopoulos, George, additional, Christidi, Fotini, additional, Gatzonis, Stergios, additional, Zalonis, Ioannis, additional, Nikolaou, George, additional, and Triantafyllou, Nikolaos, additional
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- 2014
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114. Spiritual Well-Being Scale--Greek Version
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Darvyri, Panagiota, primary, Galanakis, Michael, additional, Avgoustidis, Adamantios G., additional, Vasdekis, Spyros, additional, Artemiadis, Artemios, additional, Tigani, Xanthi, additional, Chrousos, George P., additional, and Darviri, Christina, additional
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- 2014
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115. The Spiritual Well-Being Scale (SWBS) in Greek Population of Attica
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Darvyri, Panagiota, primary, Galanakis, Michael, additional, Avgoustidis, Adamantios G., additional, Vasdekis, Spyros, additional, Artemiadis, Artemios, additional, Tigani, Xanthi, additional, Chrousos, George P., additional, and Darviri, Christina, additional
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- 2014
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116. Self-rated health in centenarians: A nation-wide cross-sectional Greek study
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Tigani, Xanthi, primary, Artemiadis, Artemios K., additional, Alexopoulos, Evangelos C., additional, Chrousos, George P., additional, and Darviri, Christina, additional
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- 2012
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117. Determinants of Self-Rated Health in a Representative Sample of a Rural Population: A Cross-Sectional Study in Greece
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Darviri, Christina, primary, Fouka, Georgia, additional, Gnardellis, Charalambos, additional, Artemiadis, Artemios K., additional, Tigani, Xanthi, additional, and Alexopoulos, Evangelos C., additional
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- 2012
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118. Lifestyle and self-rated health: a cross-sectional study of 3,601 citizens of Athens, Greece
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Darviri, Christina, primary, Artemiadis, Artemios K, additional, Tigani, Xanthi, additional, and Alexopoulos, Evangelos C, additional
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- 2011
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119. Stress as a Risk Factor for Multiple Sclerosis Onset or Relapse: A Systematic Review
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Artemiadis, Artemios K., primary, Anagnostouli, Maria C., additional, and Alexopoulos, Evangelos C., additional
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- 2011
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120. Apoptosis of Oligodendrocytes and Post-Translational Modifications of Myelin Basic Protein in Multiple Sclerosis: Possible Role for the Early Stages of Multiple Sclerosis
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Artemiadis, Artemios K., primary and Anagnostouli, Maria C., additional
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- 2010
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121. Predicting caregiving status and caregivers’ burden in multiple sclerosis. A short report.
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Katsavos, Serafeim, Artemiadis, Artemios K., Zacharis, Markos, Argyrou, Paraskevi, Theotoka, Ilia, Chrysovitsanou, Chrysa, and Anagnostouli, Maria
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Objectives: Predicting caregiving status (CS) in multiple sclerosis (MS) is of both clinical and health policy-making value. The aim of this cross-sectional study was to assess the clinical predictors of CS, along with factors related to caregivers' stress. Methods: A sample of 342 clinically definite MS patients (67.5% females, 67.8% relapsing MS, mean age 43.1 ± 11.4 year-old, mean disease duration 147 ± 105.4 months, median Expanded Disability Status Scale -EDSS-3.0) was screened for CS. The Multiple Sclerosis Quality of Life-54 and Zarit Burden Interview were used to measure quality of patients' life and the their caregivers' burden, respectively. Results: In total, 57.9% of patients reported at least one caregiver, 97% of which were relatives or friends. Higher EDSS was associated with higher chance of reporting a caregiver. Two EDSS cut-offs were recognized; 2.0 and 4.5, the former with increased sensitivity (78.8%) and the latter with increased specificity (82.3%) to predict CS. Patients in the mild disability group (EDSS: 0–1.5) needing a caregiver had higher subjective cognitive function, implying presumably a beneficial role of care in cognition. Age and education were showed to affect CS in the moderate disability group (EDSS: 2.0–4.5). Physical and mental disability was more pronounced in patients reporting at least one caregiver in the high disability group (EDSS above 4.5). Caregivers' stress was significantly positively correlated with age, EDSS, and duration of the disease and negatively with cognitive, physical, and mental health. Discussion: In conclusion, the clinical predictors of CS are known to serve well both the researchers and the clinicians. [ABSTRACT FROM AUTHOR]
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- 2017
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122. The impact of HLA-DRB1 alleles in a Hellenic, Pediatric-Onset Multiple Sclerosis cohort: Implications on clinical and neuroimaging profile.
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Skarlis, Charalampos, Markoglou, Nikolaos, Gontika, Maria, Artemiadis, Artemios, Pons, Maria-Roser, Stefanis, Leonidas, Dalakas, Marinos, Chrousos, George, and Anagnostouli, Maria
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HLA histocompatibility antigens , *MAGNETIC resonance imaging , *MULTIPLE sclerosis , *HUMAN phenotype , *DIAGNOSTIC imaging - Abstract
Background: Pediatric-Onset Multiple Sclerosis (POMS) is considered a complex disease entity and several genetic, hormonal, and environmental factors have been associated with disease pathogenesis. Linkage studies in Caucasians have consistently suggested the human leukocyte antigen (HLA) polymorphisms, as the genetic locus most strongly linked to MS, with the HLA-DRB1*15:01 allele, being associated with both adult and pediatric MS patients. Here we aim to investigate the prevalence of the HLA-DRB1 alleles among a Hellenic POMS cohort and any possible associations with clinical and imaging disease features. Materials and methods: 100 POMS patients fulfilling the IPMSSG criteria, 168 Adult-Onset MS (AOMS) patients, and 246 Healthy Controls (HCs) have been enrolled. HLA genotyping was performed with a standard low-resolution sequence-specific oligonucleotide (SSO) technique. Results: POMS patients display a significantly increased HLA-DRB1*03 frequency compared to both HCs [24% vs. 12.6%, OR [95%CI]: 2.19 (1.21-3.97), p=0.016) and AOMS (24% vs. 13.1%, OR [95%CI]: 2.1 (1.1-3.98), p=0.034] respectively. HLA-DRB1*03-carriers display reduced risk for brainstem lesion development (OR [CI 95%]:0.19 (0.06-0.65), p=0.011). A significantly lower frequency of HLA-DRB1*07 (4% vs 13.4%, OR (95% CI): 0.27 (0.09-0.78), p= 0.017) and HLA-DRB1*11 (37% vs 52%, OR [95% CI]: 0.54 (0.34-0.87), p= 0.016) was observed in POMS compared to HCs. Conclusion: The HLA-DRB1*03 allele was associated with a higher risk for POMS, replicating our previous findings, and with a lower risk for brainstem lesion development, a common clinical and neuroimaging feature in POMS, while HLA-DRB1*07 and HLA-DRB1*11 display a protective role. These findings expand the existing knowledge of HLA associations and POMS. [ABSTRACT FROM AUTHOR]
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- 2024
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123. EEG Recordings as Biomarkers of Pain Perception: Where Do We Stand and Where to Go?
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Zis, Panagiotis, Liampas, Andreas, Artemiadis, Artemios, Tsalamandris, Gabriela, Neophytou, Panagiota, Unwin, Zoe, Kimiskidis, Vasilios K., Hadjigeorgiou, Georgios M., Varrassi, Giustino, Zhao, Yifan, and Sarrigiannis, Ptolemaios Georgios
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PAIN perception , *ELECTROENCEPHALOGRAPHY , *LARGE-scale brain networks , *BIOMARKERS , *PAIN measurement - Abstract
Introduction: The universality and complexity of pain, which is highly prevalent, yield its significance to both patients and researchers. Developing a non-invasive tool that can objectively measure pain is of the utmost importance for clinical and research purposes. Traditionally electroencephalography (EEG) has been mostly used in epilepsy; however, over the recent years EEG has become an important non-invasive clinical tool that has helped increase our understanding of brain network complexities and for the identification of areas of dysfunction. This review aimed to investigate the role of EEG recordings as potential biomarkers of pain perception. Methods: A systematic search of the PubMed database led to the identification of 938 papers, of which 919 were excluded as a result of not meeting the eligibility criteria, and one article was identified through screening of the reference lists of the 19 eligible studies. Ultimately, 20 papers were included in this systematic review. Results: Changes of the cortical activation have potential, though the described changes are not always consistent. The most consistent finding is the increase in the delta and gamma power activity. Only a limited number of studies have looked into brain networks encoding pain perception. Conclusion: Although no robust EEG biomarkers of pain perception have been identified yet, EEG has potential and future research should be attempted. Designing strong research protocols, controlling for potential risk of biases, as well as investigating brain networks rather than isolated cortical changes will be crucial in this attempt. [ABSTRACT FROM AUTHOR]
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- 2022
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124. Gluten neuropathy: electrophysiological progression and HLA associations.
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Zis, Panagiotis, Sarrigiannis, Ptolemaios, Artemiadis, Artemios, Sanders, David S., and Hadjivassiliou, Marios
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GLUTEN , *CELIAC disease , *RADIAL nerve , *TIBIAL nerve , *GLUTEN allergenicity - Abstract
Objective: Gluten neuropathy (GN) is the term used to describe peripheral neuropathy that occurs in patients with gluten sensitivity (GS) or coeliac disease (CD) in the absence of other risk factors. We aimed to describe the neurophysiological progression rate of GN across time and look into the potential role of genetic susceptibility in its development. Methods: This is a cohort study of 45 patients with GN with a mean follow-up period of 8 ± 5 years. The assessments included clinical and neurophysiological data and HLA-DQ genotyping. Results: The mean age at diagnosis was 60 ± 12 years. The majority of patients had a length-dependent neuropathy (75.6%), whereas the rest were diagnosed with sensory ganglionopathy (SG). DQA1*02-positive patients were more likely to suffer with SG compared to the DQA1*02 negative patients (60% versus 13.8%, p = 0.009). There was also a trend for statistical significance regarding the DQB1*06 allele and the DQA1*01/DQB1*06 haplotype were found more frequently in patients with GN than in healthy controls (p = 0.026 and p = 0.047, respectively). A linear effect of time on the neurophysiological findings was found in radial sensory nerve action potential (1.9% mean annual decrement, p = 0.036), sural sensory nerve action potential (3.3% mean annual decrement, p = 0.013) and tibial nerve motor compound action potential (6.5% mean annual decrement, p < 0.001) amplitudes, independently from age or gender. Conclusions: GN is a late manifestation of GS and CD. The majority of patients have the length-dependent neuropathy with a linear deterioration over time. HLA genotyping of GS and CD patients who suffer from neuropathic symptoms is recommended as it can help identifying patients at risk for developing SG. [ABSTRACT FROM AUTHOR]
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- 2021
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125. First-line disease modifying treatments in pediatric-onset multiple sclerosis in Greece: therapy initiation at more advanced age is the main cause of treatment failure, in a retrospective observational study, with a cohort from a single Multiple Sclerosis Center
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Skarlis, Charalampos, Markoglou, Nikolaos, Gontika, Maria, Bougea, Anastasia, Katsavos, Serafeim, Artemiadis, Artemios, Chrousos, George, Dalakas, Marinos, Stefanis, Leonidas, and Anagnostouli, Maria
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MULTIPLE sclerosis , *THERAPEUTICS , *TREATMENT failure , *PEDIATRIC therapy , *DEMYELINATION - Abstract
Objectives: Long-term immunomodulatory therapy of pediatric onset-multiple sclerosis (POMS) is based mainly on published case series and internationally agreed guidelines. Relevant studies in the Greek population are absent from the literature. The purpose of this study is to present data on the efficacy and safety of the 1st line immunomodulatory drugs in the treatment of POMS patients. Materials and methods: The present study included 27 patients meeting the IPMSSG criteria for POMS and who are monitored at the outpatient clinic of the Multiple Sclerosis and Demyelinating Diseases Unit (MSDDU), of the 1st Neurological Department, University Hospital of Aeginition. All patients received 1st line immunomodulatory drugs as initial therapy. Clinical, laboratory, and imaging parameters of the disease were recorded before and after treatment. Results: Post-treatment, a significant reduction of the relapse number (mean ± SD: 2.0 ± 1.0 vs 1.2 ± 1.6, p = 0.002), EDSS progression (mean ± SD: 1.5 ± 0.8 vs 0.9 ± 0.7, p = 0.005) and ARR (mean ± SD: 1.5 ± 0.7 vs 0.4 ± 0.5, p = 0.0001) was observed, while no changes were observed in the EDSS score, (mean ± SD: 1.8 ± 0.6 vs 1.9. 0.6, p = 0.60). Advanced age at treatment initiation increased the risk for drug discontinuation before 24 months of therapy (HR = 0.6, 95% CI (0.35–0.99), p = 0.04). Conclusions: Most pediatric patients are forced to switch to either more efficacious 1st line or 2nd line drugs. Additionally, our study suggests that older age at the time of the 1st line treatment initiation, contributes to earlier drug discontinuation. [ABSTRACT FROM AUTHOR]
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- 2023
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126. Immunoglobulin Use for the Management of Painful Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
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Zis, Panagiotis, Liampas, Andreas, Pozotou, Theodora, Parperis, Konstantinos, Artemiadis, Artemios, and Hadjigeorgiou, Georgios
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POLYNEUROPATHIES , *PERIPHERAL neuropathy , *CHRONIC inflammatory demyelinating polyradiculoneuropathy , *GUILLAIN-Barre syndrome , *IMMUNE response , *FC receptors - Abstract
Background: Immunoglobulins (IG) are widely used for the treatment of a variety of immune-mediated diseases. The exact mechanism of action remains unknown, but IG modulate the expression and function of Fc receptors, interfere with complement activation and production of cytokines, neutralize pathogenic autoantibodies, and affect the activation and effector functions of B and T lymphocytes. Immunoglobulins are usually delivered intravenously, and are effective in ameliorating motor symptoms, and/or preventing disease progression in immune-mediated neuropathies, including Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy. Objective: The aim of this systematic review and meta-analysis was to study the potential of IG for the treatment of painful peripheral neuropathy (PPN). The outcome of interest was the percentage of patients with PPN who achieved pain relief following IG administration. Methods: We performed a systematic literature search on March 17, 2022, in the PubMed database without any publication date restrictions. We also looked for unpublished or ongoing trials in clinicaltrials.org. Pain reduction following IG treatment had to be within the aims (primary or secondary). Results: The aforementioned literature search strategy revealed five studies (two open-label, three randomized placebo-controlled) eligible to be included. The pooled estimate of the percentage of patients with PPN who received immunoglobulins and reported pain relief was found to be 65% (95% CI 58–71%). The likelihood of achieving pain relief with immunoglobulin treatment was 2.9 times higher (95% CI 1.6–5.2) compared to placebo (p = 0.0003). Conclusion: The use of IG for the treatment of pain due to peripheral neuropathy has a potential therapeutic benefit. Further studies across patients with different types of painful peripheral neuropathy are needed to better characterize this effect. Registration number on PROSPERO: CRD42022319614. [ABSTRACT FROM AUTHOR]
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- 2022
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127. Trained immunity in viral infections, Alzheimer's disease and multiple sclerosis: A convergence in type I interferon signalling and IFNβ-1a.
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Vavougios, George D., Mavridis, Theodore, Artemiadis, Artemios, Krogfelt, Karen A., and Hadjigeorgiou, Georgios
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Type I interferon (IFN-I) signalling represents a major target for modulation in a virus' bid for latency. IFN-I perturbations are also present in such as Alzheimer's disease (AD) and multiple sclerosis (MS), where viral infections are known to increase symptomatic burden. IFN-I modulation such as via IFNβ-1a, an established MS treatment, has been researched to a limited extent to both AD and COVID-19. In this mini review, we present emerging research on trained immunity as a pathogenetic basis for Alzheimer's disease and the emerging context for IFNβ-1a repositioning, via mechanisms shared with multiple sclerosis and induced by viral infections. • Type I interferon responses a perturbed in neurodegenerative disease and infection. • IFNβ etiologically restores canonical Type I interferon signalling in viral infection. • IFNβ-1α ameliorates neuroinflammation and cognitive decline in multiple sclerosis. • IFNβ-1α has shown efficacy in modulating hyperinflammation in COVID-19. • IFNβ-1α repositioning may be efficacious in Type I interferon signalling-driven cognitive decline. [ABSTRACT FROM AUTHOR]
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- 2022
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128. The Greek Version of the Vanderbilt ADHD Diagnostic Parent Rating Scale for Follow-up Assessment in Prepubertal Children with ADHD.
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Kapogiannis, August, Makris, Gerasimos, Darviri, Christina, Artemiadis, Artemios, Klonaris, Dionysios, Tsoli, Sofia, Bachourou, Theodora, Stefanaki, Charikleia, Papanikolaou, Katerina, Chrousos, George, and Pervanidou, Panagiota
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STATISTICAL reliability , *RESEARCH methodology evaluation , *ATTENTION-deficit hyperactivity disorder , *PSYCHOMETRICS , *PEARSON correlation (Statistics) , *CRONBACH'S alpha , *FACTOR analysis , *DESCRIPTIVE statistics , *STATISTICAL correlation , *DATA analysis software , *CHILDREN ,RESEARCH evaluation - Abstract
Given the heterogeneity of Attention-Deficit Hyperactivity Disorder (ADHD), there is a constant need for proper diagnosis, employing more accurate, efficient, patient-friendly, and clinician-friendly tools. We developed a Greek version of the National Institute for Children's Health Quality (NICHQ) Vanderbilt ADHD Diagnostic Parent Rating Scale (VADPRS) for follow-up assessment and examined its reliability and validity. A total of 100 schoolchildren (65 girls and 35 boys) between 7 and 12 years old with ADHD were included in the study. The internal consistency and test–retest reliability were examined via principal component analysis. Three-component structure in our study accounts for 74.63% of the tool's variance. The questions' loadings onto the factors and the internal reliability of the three factors were satisfactory. Finally, the reliability of all factors presented was found adequately high, confirming the high internal consistency of the items. Our results suggest that the Greek version of the VADPRS-follow-up may be used as an accurate psychometric instrument for the purposes of diagnosing ADHD. Furthermore, the combined use of the VADPRS-follow-up with other widely accepted tools, such as the ADHD Rating Scale-IV, may present clinical utility in collating parent information concerning the behavioural phenotype of their children. [ABSTRACT FROM AUTHOR]
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- 2022
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129. Sudomotor dysfunction in patients with gluten neuropathy.
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Zis, Panagiotis, Shafique, Faiza, Sarrigiannis, Ptolemaios G., Artemiadis, Artemios, Rao, Dasappaiah G., Sanders, David S., and Hadjivassiliou, Marios
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Background and aim: Gluten neuropathy (GN) is a common neurological manifestation of gluten sensitivity (GS), characterized by serological evidence of GS, while other risk factors for developing neuropathy are absent. The degree of small fiber dysfunction in GN has not been studied in depth to date. Small fiber involvement may lead to pain, thermal perception abnormalities, and sweat gland dysfunction. Sudomotor innervation refers to the cholinergic innervation of the sympathetic nervous system through small fibers in the sweat glands. The aim of our study was to assess the sudomotor function of GN patients. Methods: Patients with GN were recruited. Clinical and neurophysiological data were obtained. HLA-DQ genotyping was performed. The skin electrochemical conductance (ESC) was measured with SUDOSCANTM. Results: Thirty-two patients (25 males, mean age 69.5±10.2 years) were recruited. Thirteen patients (40.6%) had abnormal sudomotor function of the hands. Sixteen patients (50%) had abnormal sudomotor function of the feet. Twenty-one patients (65.6%) had abnormal sudomotor function of either the hands or feet. Sudomotor dysfunction did not correlate with the type of neuropathy (length-dependent neuropathy or sensory ganglionopathy), gluten-free diet adherence, severity of neuropathy, and duration of disease or HLA-DQ genotype. No differences in the ESC were found between patients with painful and patients with painless GN. Conclusion: Sudomotor dysfunction affects two-thirds of patients with GN. The lack of correlation between pain and sudomotor dysfunction suggests different patterns of small fiber involvement in patients with GN. [ABSTRACT FROM AUTHOR]
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- 2022
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130. The effects of Pythagorean Self-Awareness Intervention on patients with major depressive disorder: A pilot randomized controlled trial.
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Psarraki, Evgenia E., Bacopoulou, Flora, Panagoulias, Eustathios, Michou, Maria, Pelekasis, Panagiotis, Artemiadis, Artemios, Chrousos, George P., and Darviri, Christina
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MENTAL depression , *PERCEIVED Stress Scale , *COGNITIVE ability , *SELF-consciousness (Awareness) , *QUALITY of life , *MENTAL health - Abstract
Stress plays an important role in major depressive disorder (MDD). Thus, a variety of stress management programs have been developed for people with this diagnosis. This is a pilot randomized clinical trial which implemented a holistic stress management program, Pythagorean Self-Awareness Intervention (PSAI) in adults with MDD, aiming to evaluate the effectiveness of PSAI compared to standard care for reduction of depressive symptoms (primary aim), improving mental health and quality of life (secondary aims). A total of 69 participants were randomized to an intervention group (N = 34), who received the usual care provided for patients with major depression and attended the PSAI program, and a control group (N = 35), who received the usual care only. Measurements were taken in both groups before and after the intervention and included: 1. Self-report questionnaires for measuring depressive symptoms, healthy lifestyle, perceived stress, anxiety, positive and negative affect and sleep quality, 2 Cognitive function assessment tools, 3. Hair and salivary cortisol. The intervention group demonstrated significantly greater reductions in depressive symptoms, negative affect, perceived stress, sleep quality and significantly greater increase in visual memory and healthy lifestyle compared to the control group. In addition, the intervention group demonstrated a significant reduction in first morning salivary cortisol, indicating a reduction in diurnal stress levels, while no significant change of salivary cortisol was observed in the control group. Finally, none of the study's groups demonstrated a significant change in hair cortisol concentration. In conclusion, PSAI can be applied to adults suffering from MDD with significant benefits for their mental health and quality of life. ClinicalTrials.gov Identifier: NCT04536714. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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131. Is there a relation between major depression and hair cortisol? A systematic review and meta-analysis.
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Psarraki, Evgenia E., Kokka, Ioulia, Bacopoulou, Flora, Chrousos, George P., Artemiadis, Artemios, and Darviri, Christina
- Subjects
- *
MENTAL depression , *POSTPARTUM depression , *HYDROCORTISONE , *COMPULSIVE hair pulling , *RANDOM effects model , *HAIR - Abstract
Literature supports a causal role of stress in major depressive disorder (MDD). Hair cortisol concentration (HCC) has been widely used as a measure of long-term stress. Although elevated HCC has been observed in healthy people experiencing chronic stress, findings regarding individuals with mental disorders have been complicated. This review attempts to systematically present all the published research on major depression and HCC. An extensive search of databases was performed to identify articles that investigated this question. The initial search retrieved 142 studies, of which, 16 original articles were included in this review. Results were contradictory; most of the studies showed no significant HCC differences between MDD patients and controls, while others indicated either higher or lower HCC in MDD patients than controls. Higher HCC was reported in first depressive episode compared to recurrent MDD and controls; patients with comorbid MDD and anxiety disorder had higher HCC than controls. No significant HCC difference was found between patients with melancholic or atypical depression and controls. Findings concerning HCC in postpartum depression were inconsistent. A meta-analysis of the data extracted from seven studies of the sample was performed to quantify the degree of cortisol change in MDD patients vs. controls. A random effects model revealed no significant hair cortisol concentrations difference between depressed patients and healthy controls (SMD: −0.02, 95% CI: −0.36 to 0.32). Significant heterogeneity was identified across included studies (P = 0.002, I2 = 71%). The disagreement among studies' results indicates that there is room for improvement in this research field. Confounding factors independent of depression should be taken into consideration. • Evidence on hair cortisol concentrations in major depression is inconsistent. • Meta-analysis revealed similar hair cortisol between depressed and healthy subjects. • Childhood trauma, anxiety and recurrence of depression may play a mediating role. • Hair cortisol in patients with melancholic/atypical depression is similar to controls. • Research in the field is limited and conclusions cannot be drawn with certainty. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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132. Implication of Apolipoprotein E gene variants in pediatric-onset multiple sclerosis: Possible association with disease susceptibility and its clinical characteristics, in a Hellenic cohort.
- Author
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Skarlis C, Markoglou N, Artemiadis A, Gontika M, Koutsis G, Chrousos G, and Anagnostouli M
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- Humans, Male, Female, Adult, Adolescent, Child, Greece, Young Adult, Age of Onset, Cohort Studies, Apolipoprotein E2 genetics, Apolipoprotein E3 genetics, Multiple Sclerosis genetics, Genetic Predisposition to Disease, Apolipoproteins E genetics
- Abstract
Background: Apolipoprotein E (ApoE) plays a major role in lipid homeostasis and myelination in the central nervous system. Although ApoE gene variants have been linked with cognitive impairment in the setting of Multiple sclerosis (MS), no association with disease susceptibility was found, while similar studies in pediatric-onset MS (POMS) are limited., Objective: This study aims to explore the role of ApoE gene variants in the POMS susceptibility of a Hellenic cohort and any association with disease features., Methods: 112 POMS, fulfilling the revised IPMSSG 2013 criteria, 391 adult-onset MS (AOMS) and 200 healthy controls (HCs), were enrolled. After DNA extraction, ApoE genotyping was performed by a polymerase chain reaction and sequence-specific-oligonucleotide technique., Results: ApoE2/E3 genotype and ApoE2 allele were found to be significantly more frequent among POMS patients compared to HCs [(20.5% vs 11 %, OR [95 %]: 2.1 (1.1-4.0), p = 0.03)], and [(11% vs 5.3 %, OR [95 %]: 2.3 (1.2-4.1), p = 0.01)], respectively. Additionally, significantly lower frequencies of the ApoE3/E3 genotype and the ApoE3 allele were observed in POMS patients compared to HCs (59.8% vs 79 %, OR [95 %]:0.40 (0.24-0.65), p = 0.0005 and 79% vs 89 % 0.46, OR [95 %]: (0.30-0.73), p = 0.001)], respectively., Conclusions: The ApoE2 allele may represent a novel risk factor for POMS development., Competing Interests: Declaration of competing interest None., (Copyright © 2024. Published by Elsevier B.V.)
- Published
- 2024
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133. Letter to the editor regarding sensorineural hearing loss following laparoscopic sleeve gastrectomy: a case report.
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Liampas A, Theologou R, Agkastinioti E, Hadjigeorgiou GM, and Artemiadis A
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- Humans, Female, Postoperative Complications etiology, Postoperative Complications diagnostic imaging, Adult, Gastrectomy adverse effects, Gastrectomy methods, Hearing Loss, Sensorineural etiology, Hearing Loss, Sensorineural surgery, Laparoscopy adverse effects
- Published
- 2024
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134. Adult Neoneurogenesis and Oligodendrogenesis in Multiple Sclerosis: A Systematic Review of Human and Animal Studies.
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Liampas A, Tseriotis VS, Artemiadis A, Zis P, Argyropoulou C, Grigoriadis N, Hadjigeorgiou GM, and Vavougyios G
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- Animals, Humans, Cell Differentiation physiology, Encephalomyelitis, Autoimmune, Experimental pathology, Encephalomyelitis, Autoimmune, Experimental metabolism, Lateral Ventricles pathology, Multiple Sclerosis pathology, Multiple Sclerosis metabolism, Neural Stem Cells pathology, Neurogenesis physiology, Oligodendroglia pathology, Oligodendroglia metabolism
- Abstract
Introduction: The subventricular zone promotes remyelination through activation differentiation of oligodendroglial precursor cells (OPCs) and neural stem cells (NSCs) into mature oligodendrocytes and thus in the adult brain. In multiple sclerosis (MS) this regenerative capability is halted resulting in neurodegeneration. We aimed to systematically search and synthesize evidence on mechanisms and phenomena associated with subventricular zone (SVZ) dysfunction in MS. Materials and Methods: Our systematic review was reported according to the PRISMA-ScR statement. MEDLINE, SCOPUS, ProQuest, and Google Scholar were searched using the terms "subventricular zone" and "multiple sclerosis," including English-written in vivo and postmortem studies. Results: Twenty studies were included. Thirteen studies on models of experimental autoimmune encephalomyelitis (EAE) reported among others strong stathmin immunoreactivity in the SVZ of EAE models, the role of MOG immunization in neurogenesis impairment, the effect of parenchymal OPCs and NSCs in myelin repair, and the importance of ependymal cells (E1/E2) and ciliated B1 cells in SVZ stem cell signaling. CXCR4 signaling and transcriptional profiles of SVZ microglia, Gli1 pathway, and galactin-3 were also explored. Studies in humans demonstrated microstructural SVZ damage in progressive MS and the persistence of black holes near the SVZ, whereas postmortem confirmed the generation of polysialic acid-neural cell adhesion molecule and NG2-positive progenitors through SVZ activation, SVZ stathmin immunoreactivity, Shh pathway, and Gal-3 upregulation. Discussion: Oligodendrogenesis defects translate to reduced remyelination, a hallmark of MS that determines its end-phenotype and disease course. Conclusion: The role of inflammation and subsequent SVZ microenvironment disruption is evident in MS pathology.
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- 2024
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135. Miller Fischer syndrome after COVID-19 infection and vaccine: a systematic review.
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Neophytou P, Artemiadis A, Hadjigeorgiou GM, and Zis P
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- Adult, Female, Humans, Male, Middle Aged, COVID-19 Vaccines adverse effects, SARS-CoV-2, COVID-19 prevention & control, COVID-19 complications, Miller Fisher Syndrome epidemiology, Miller Fisher Syndrome etiology, Ophthalmoplegia etiology, Vaccines
- Abstract
Background: COVID-19 (CoranaVirus disease 2019) is an ongoing infectious disease caused by the RNA SARS-CoV-2 virus (Severe Acute Respiratory Syndrome CoronaVirus-2). The virus mainly causes respiratory symptoms, but neurological symptoms have also been reported to be part of the clinical manifestations of the disease. The aim of this study was to systematically review Miller fisher syndrome (MFS) published cases, in the context of COVID-19 infection or vaccination., Methods: A systematic literature review on Medline was performed. A total of 21 papers were included in the present review., Results: Twenty-two MFS cases (77% males) were identified, 14 related to COVID-19 infection and 8 to vaccination against COVID-19. The median age of the adult patients was 50 years (interquartile range 36-63 years). Sixteen patients (73%) had the classic triad of MFS (ophthalmoplegia, ataxia, areflexia), four (18%) had acute ophthalmoplegia and one other characteristic symptom and two patients (9%) had only one other characteristic symptom, but they tested positive for GQ1b antibodies. Nine (41%) patients had positive GQ1b antibodies and were classified as "definite" MFS. Albuminocytologic dissociation was found in half of the cases. The outcome was favourable in the majority of cases (86%) whereas one patient, despite the initial improvement, died because of a cardiac arrest, after cardiac arrythmia., Conclusions: MFS after COVID-19 infection/vaccination was found to have the typical epidemiological characteristics of classic MFS; being rare, occurring more often after infection than vaccination, affecting mainly middle-aged males usually within 3 weeks after the event and having an excellent prognosis after treatment with IVIG or even with no treatment at all. We found no evidence that MFS after COVID-19 infection was different from MFS after COVID-19 vaccination, although the former tended to occur earlier., (© 2023. The Author(s).)
- Published
- 2023
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136. Osmotic demyelination syndrome improving after immune-modulating treatment: Case report and literature review.
- Author
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Kalampokini S, Artemiadis A, Zis P, Hadjihannas L, Parpas G, Kyrri A, and Hadjigeorgiou GM
- Subjects
- Brain diagnostic imaging, Demyelinating Diseases diagnostic imaging, Humans, Hyponatremia diagnostic imaging, Magnetic Resonance Imaging, Male, Middle Aged, Treatment Outcome, Demyelinating Diseases drug therapy, Hyponatremia drug therapy, Immunoglobulins, Intravenous therapeutic use, Immunologic Factors therapeutic use
- Abstract
Background: Osmotic demyelination syndrome (ODS), which embraces central pontine and extrapontine myelinolysis, is an uncommon neurological disorder that occurs due to plasma osmotic changes., Case Presentation: We present the case of a 55-year-old man, who presented with severe hyponatremia due to repeated vomiting, antidepressant treatment and consumption of large amounts of water. Fifteen days after sodium correction, the patient showed fluctuation of vigilance, dysarthria and dysphagia, tremor, cogwheel rigidity, bilateral facial palsy, ophthalmoplegia and tetraparesis. A brain MRI scan revealed extrapontine and later on pontine myelinolysis. He received intravenous steroids and subsequently immunoglobulin. His status began to improve gradually after completion of immunoglobulin and at three month-follow-up had no neurological deficit., Literature Review: A comprehensive literature search of all reported ODS cases that received immunoglobulin, steroids or plasmapheresis was conducted in the electronic databases PubMed and Web of science., Conclusions: Improvement was seen in most cases that received immunoglobulin either during treatment or in the first days after treatment. With regard to steroids, although most cases reported improvement in the following months their effect on the outcome is unclear. Most cases treated with plasmapheresis reported favorable outcome at variable follow-up time. Immunoglobulin and steroids have immunomodulatory effects, which could contribute to promotion of myelin repair in ODS. Plasmapheresis has effects on the immune system beyond removing myelinotoxins from the circulation. More evidence is required to support their use in ODS. However, in view of the disease severity, these therapeutic choices should be considered in the clinical management of ODS., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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137. Computerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: an explorative study.
- Author
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Vilou I, Bakirtzis C, Artemiadis A, Ioannidis P, Papadimitriou M, Konstantinopoulou E, Aretouli E, Messinis L, Nasios G, Dardiotis E, Kosmidis M, and Grigoriadis N
- Subjects
- Adult, Cognitive Dysfunction etiology, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting complications, Pilot Projects, Therapy, Computer-Assisted, Cognitive Dysfunction physiopathology, Cognitive Dysfunction rehabilitation, Cognitive Remediation, Cognitive Reserve physiology, Multiple Sclerosis, Relapsing-Remitting rehabilitation, Outcome Assessment, Health Care
- Abstract
In this explorative study, forty-seven patients with relapsing-remitting multiple sclerosis were randomized to a custom 6-week cognitive rehabilitation intervention (n = 23) using the BrainHQ
TM web-based platform and to a control group condition (n = 24). Cognitive rehabilitation intervention consisted of two 40-minute sessions per week. All patients were tested with the Brief International Cognitive Assessment for Multiple Sclerosis battery, the Stroop Color-Word Test, and the trail making test, while the Beck Depression Inventory - Fast Screen questionnaire was used as a measure of mood and the cognitive reserve index as a measure of cognitive reserve. We used the reliable change index, to calculate clinically meaningful changes of performance, and to discriminate between responders and non-responders of this intervention. Statistically significant improvement of the group receiving treatment was observed mainly on measures of verbal and non-verbal episodic memory and, to a lesser extent, on reading speed, selective attention/response inhibition, and visual attention. Verbal memory and visual attention improvements remained significant after considering the corrected for multiple comparisons level of significance. According to reliable change index scores, 12/23 (52.2%) of patients in the intervention group presented meaningful improvement in at least one measure (Greek Verbal Learning Test: 26%, Brief Visuospatial Memory Test-Revised: 17.4%, Stroop-Words test: 13%). This explorative study provides evidence that, at least in the short term, cognitive rehabilitation may improve the cognitive performance of multiple sclerosis patients., Competing Interests: The authors declare no conflict of interest., (© 2020 Vilou et al. Published by IMR press.)- Published
- 2020
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138. An 8-week Stress Management Program in Information Technology Professionals and the Role of a New Cognitive Behavioral Method: a Pilot Randomized Controlled Trial.
- Author
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Sioula EK, Tigani X, Artemiadis AK, Vlachakis D, Chrousos GP, Darviri C, and Alexopoulos EC
- Abstract
Aim: The aim of this study is to compare and evaluate the sort-term benefits of the effects of an 8-week stress management techniques in information technology professionals., Methods: In this parallel randomized controlled trial, participants were randomly assigned to either the stress management group (n=40; relaxation breathing, progressive muscle relaxation, guided imagery) or in the Pythagorean Self awareness group (n=41). Self-reported validated measures were used to evaluate perceived stress, health locus of control, anxiety and depression., Results: All groups were found with significantly better cognitive speed and verbal memory at the end of the follow-up. Taking into account the group by time interaction coefficients, PSAT was found significantly superior to standard SM with regards to depression, emotional intelligence, lifestyle and personal control and verbal memory suggesting that verbal memory improvement through time should be mostly attributed to PSAT. On the other hand, the cognitive speed improvement during follow-up should be attributed to both interventions., Conclusions: These findings provide important insight into the role of stress management. Future studies should focus on randomized, controlled trials with larger samples and longer follow-up times., Competing Interests: Conflicts of Interest The authors have no conflict of interest to declare.
- Published
- 2020
139. Stress Management in Women with Hashimoto's thyroiditis: A Randomized Controlled Trial.
- Author
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Markomanolaki ZS, Tigani X, Siamatras T, Bacopoulou F, Tsartsalis A, Artemiadis A, Megalooikonomou V, Vlachakis D, Chrousos GP, and Darviri C
- Abstract
Aim: Stress has been implicated in the pathogenesis of Hashimoto's thyroiditis (HT), nevertheless evidence is scarce regarding the effect of stress management on individuals suffering from HT. The purpose of this study was to evaluate the impact of an 8-week stress management intervention on the anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies as well as thyroid-stimulating hormone (TSH) levels of women with HT. Secondary endpoints included the effect on the patients' lifestyle, body mass index (BMI), depression, anxiety and stress., Methods: This was a two-arm parallel group (stress management intervention vs. standard care groups) randomized controlled study. Adult women with Hashimoto's thyroiditis, completed questionnaires on stress, anxiety, depression and lifestyle, at the beginning of the programme and 8 weeks later. Laboratory thyroid function tests (anti-TPO, anti-TG antibodies and TSH) were also measured at baseline and at the end of the study., Results: A total of 60 women with HT, aged 25-76 years, participated in the study (30 patients in each group). After eight weeks, patients in the intervention group demonstrated statistically significant beneficial decrements in the rate change of anti-TG titers and the levels of stress, depression and anxiety as well as better lifestyle scores, compared to the control group., Competing Interests: Conflict of Interest Authors declare no conflicts of interest.
- Published
- 2019
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