2,779 results on '"Arriaga, P."'
Search Results
102. Model-informed precision dosing of antimicrobial drugs in pediatrics: experiences from a pilot scale program
- Author
-
Velarde-Salcedo, Rodrigo, Pérez-González, Luis Fernando, Rodríguez-Báez, Ana Socorro, Arriaga-García, Francisco Javier, Milán-Segovia, Rosa del Carmen, Romano-Moreno, Silvia, and Medellín-Garibay, Susanna Edith
- Published
- 2023
- Full Text
- View/download PDF
103. Lung ultrasound and postoperative follow-up of congenital diaphragmatic hernia
- Author
-
Gregorio-Hernández, R., Ramos-Navarro, C., Vigil-Vázquez, S., Rodríguez-Corrales, E., Pérez-Pérez, A., Arriaga-Redondo, M., and Sánchez-Luna, M.
- Published
- 2023
- Full Text
- View/download PDF
104. Formation of polymeric filtration membranes by the combination of emulsion and breath figures approach
- Author
-
López-Vega, Dulce, Pérez-Rodríguez, Fátima, Acosta-González, Guillermo, Labrada-Delgado, Gladis Judith, Arriaga, Sonia, García-Castañeda, María Concepción, and Nieto-Delgado, Cesar
- Published
- 2023
- Full Text
- View/download PDF
105. Effect of Annealing and Silver Content on the Mechanical Properties of Zn-Al-Ag Alloys
- Author
-
Miguel Angel Rubio-Padrón, Olga Alondra Echartea-Reyes, Carlos A. Calles-Arriaga, and Enrique Rocha-Rangel
- Subjects
zn-al-ag ,powder metallurgy ,mechanical properties ,silver ,annealing ,Mining engineering. Metallurgy ,TN1-997 ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Through the powder metallurgy technique, alloys of the eutectic composition of the Zn-Al system were manufactured (22.3 wt.%Al), reinforced with Ag additions (0.5, 1, 2.5, 5 wt.%), with subsequent annealing heat treatment at three different temperatures; 100, 150 and 200°C for 1 hr. X-ray diffraction, optical microscopy and mechanical tests were performed on the resulting samples. The addition of Ag favors the formation of alpha and beta compounds with Al and Zn respectively, which improves the compressive strength of the alloy. However, with the presence of Ag the hardness is decreased. On the other hand, the application of an annealing heat treatment, shows no significant effect on the evaluated properties of the alloy. The microstructure of the alloys resulted in the presence of very small grains smaller than 1 mm and with rounded morphology.
- Published
- 2023
- Full Text
- View/download PDF
106. Potential biomarkers for fatal outcome prognosis in a cohort of hospitalized COVID‐19 patients with pre‐existing comorbidities
- Author
-
Ruth Lizzeth Madera‐Sandoval, Arturo Cérbulo‐Vázquez, Lourdes Andrea Arriaga‐Pizano, Graciela Libier Cabrera‐Rivera, Edna Basilio‐Gálvez, Patricia Esther Miranda‐Cruz, María Teresa García de la Rosa, Jessica Lashkmin Prieto‐Chávez, Silvia Vanessa Rivero‐Arredondo, Alonso Cruz‐Cruz, Daniela Rodríguez‐Hernández, María Eugenia Salazar‐Ríos, Enrique Salazar‐Ríos, Esli David Serrano‐Molina, Roberto Carlos De Lira‐Barraza, Abel Humberto Villanueva‐Compean, Alejandra Esquivel‐Pineda, Rubén Ramírez‐Montes de Oca, Omar Unzueta‐Marta, Guillermo Flores‐Padilla, Juan Carlos Anda‐Garay, Luis Alejandro Sánchez‐Hurtado, Salvador Calleja‐Alarcón, Laura Romero‐Gutiérrez, Rafael Torres‐Rosas, Laura C. Bonifaz, Rosana Pelayo, Edna Márquez‐Márquez, Constantino I. I. I. Roberto López‐Macías, and Eduardo Ferat‐Osorio
- Subjects
Therapeutics. Pharmacology ,RM1-950 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract The difficulty in predicting fatal outcomes in patients with coronavirus disease 2019 (COVID‐19) impacts the general morbidity and mortality due to severe acute respiratory syndrome‐coronavirus 2 infection, as it wears out the hospital services that care for these patients. Unfortunately, in several of the candidates for prognostic biomarkers proposed, the predictive power is compromised when patients have pre‐existing comorbidities. A cohort of 147 patients hospitalized for severe COVID‐19 was included in a descriptive, observational, single‐center, and prospective study. Patients were recruited during the first COVID‐19 pandemic wave (April–November 2020). Data were collected from the clinical history whereas immunophenotyping by multiparameter flow cytometry analysis allowed us to assess the expression of surface markers on peripheral leucocyte. Patients were grouped according to the outcome in survivors or non‐survivors. The prognostic value of leucocyte, cytokines or HLA‐DR, CD39, and CD73 was calculated. Hypertension and chronic renal failure but not obesity and diabetes were conditions more frequent among the deceased patient group. Mixed hypercytokinemia, including inflammatory (IL‐6) and anti‐inflammatory (IL‐10) cytokines, was more evident in deceased patients. In the deceased patient group, lymphopenia with a higher neutrophil‐lymphocyte ratio (NLR) value was present. HLA‐DR expression and the percentage of CD39+ cells were higher than non‐COVID‐19 patients but remained similar despite the outcome. Receiver operating characteristic analysis and cutoff value of NLR (69.6%, 9.4), percentage NLR (pNLR; 71.1%, 13.6), and IL‐6 (79.7%, 135.2 pg/mL). The expression of HLA‐DR, CD39, and CD73, as many serum cytokines (other than IL‐6) and chemokines levels do not show prognostic potential, were compared to NLR and pNLR values.
- Published
- 2023
- Full Text
- View/download PDF
107. Abiotic, Hybrid, and Biological Electrocatalytic Materials Applied in Microfluidic Fuel Cells: A Comprehensive Review
- Author
-
D. V. Estrada-Osorio, Ricardo A. Escalona-Villalpando, M. P. Gurrola, Ricardo Chaparro-Sánchez, J. A. Rodríguez-Morales, L. G. Arriaga, and J. Ledesma-García
- Subjects
Analytical chemistry ,QD71-142 - Published
- 2023
- Full Text
- View/download PDF
108. Information and Communication Security Mechanisms For Microservices-based Systems
- Author
-
Leines-Vite, Lenin, Pérez-Arriaga, Juan Carlos, and Limón, Xavier
- Subjects
Computer Science - Cryptography and Security - Abstract
Security has become paramount in modern software services as more and more security breaches emerge, impacting final users and organizations alike. Trends like the Microservice Architecture bring new security challenges related to communication, system design, development, and operation. The literature presents a plethora of security-related solutions for microservices-based systems, but the spread of information difficult practitioners' adoption of novel security related solutions. In this study, we aim to present a catalogue and discussion of security solutions based on algorithms, protocols, standards, or implementations; supporting principles or characteristics of information security, considering the three possible states of data, according to the McCumber Cube. Our research follows a Systematic Literature Review, synthesizing the results with a meta-aggregation process. We identified a total of 30 primary studies, yielding 75 security solutions for the communication of microservices., Comment: 19 pages, 4 Figures, 5 tables
- Published
- 2021
- Full Text
- View/download PDF
109. Recent Advances in Biological and Catalytic Applications of Metal Complexes
- Author
-
Jose Manuel Mendez-Arriaga
- Subjects
n/a ,Inorganic chemistry ,QD146-197 - Abstract
The use of metals in biological [...]
- Published
- 2024
- Full Text
- View/download PDF
110. Outcomes of a Self-Management Program for People with Non-Communicable Diseases in the Context of COVID-19
- Author
-
Rodrigo Cesar León Hernández, Jorge Luis Arriaga Martínez, Martha Arely Hernández Del Angel, Isabel Peñarrieta de Córdova, Virginia Solís Solís, and María Elena Velásquez Salinas
- Subjects
depression ,physical activity ,self-management ,non-communicable diseases ,Medicine - Abstract
Objective: To evaluate the effectiveness of the online version of the Chronic Disease Self-Management Program (CDSMP) on physical activity and depressive symptoms in individuals with non-communicable diseases (NCDs) in Mexico and Peru during the COVID-19 pandemic. Materials and Methods: Quasi-experimental study with a non-probability sample of 114 people with NCDs, recruited by invitation in Mexico and by convenience in Peru. The participants were assigned to intervention (n = 85) and control (n = 29) groups. The Personal Health Questionnaire (PHQ-8) and the Physical Activity Scale were used to assess the outcomes. Measurements were taken before and after the intervention. The CDSMP comprises six sessions that take place once per week and last 2.5 h each. Results: The intervention group showed a significant reduction in depressive symptoms and an increase in physical activity (PA) at the end of the program. In contrast, the control group showed no significant improvement in depression and presented a significant decrease in PA.
- Published
- 2024
- Full Text
- View/download PDF
111. Levels of Plasma Endothelin-1, Circulating Endothelial Cells, Endothelial Progenitor Cells, and Cytokines after Cardiopulmonary Bypass in Children with Congenital Heart Disease: Role of Endothelin-1 Regulation
- Author
-
Angélica Rangel-López, Héctor González-Cabello, María Eugenia Paniagua-Medina, Ricardo López-Romero, Lourdes Andrea Arriaga-Pizano, Miguel Lozano-Ramírez, Juan José Pérez-Barragán, Horacio Márquez-González, Dulce María López-Sánchez, Minerva Mata-Rocha, Ramon Paniagua-Sierra, Abraham Majluf-Cruz, Dina Villanueva-García, Sergio Zavala-Vega, Juan Carlos Núñez-Enríquez, Juan Manuel Mejía-Aranguré, and José Arellano-Galindo
- Subjects
endothelin-1 ,circulating endothelial cells ,endothelial progenitor cells ,cytokines ,congenital heart disease ,cardiopulmonary bypass surgery ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Congenital heart disease (CHD) can be complicated by pulmonary arterial hypertension (PAH). Cardiopulmonary bypass (CPB) for corrective surgery may cause endothelial dysfunction, involving endothelin-1 (ET-1), circulating endothelial cells (CECs), and endothelial progenitor cells (EPCs). These markers can gauge disease severity, but their levels in children’s peripheral blood still lack consensus for prognostic value. The aim of our study was to investigate changes in ET-1, cytokines, and the absolute numbers (Ɲ) of CECs and EPCs in children 24 h before and 48 h after CPB surgery to identify high-risk patients of complications. A cohort of 56 children was included: 41 cases with CHD-PAH (22 with high pulmonary flow and 19 with low pulmonary flow) and 15 control cases. We observed that Ɲ-CECs increased in both CHD groups and that Ɲ-EPCs decreased in the immediate post-surgical period, and there was a strong negative correlation between ET-1 and CEC before surgery, along with significant changes in ET-1, IL8, IL6, and CEC levels. Our findings support the understanding of endothelial cell precursors’ role in endogenous repair and contribute to knowledge about endothelial dysfunction in CHD.
- Published
- 2024
- Full Text
- View/download PDF
112. Short Glass Fiber Modifier Trisilanol–Isobutyl Polyhedral Silsesquioxane as Interfacial in Polypropylene Matrix: Effect of Flame Retardation and Mechanical Properties
- Author
-
Ana Beatriz Morales Cepeda, Diego Armando Quiñones Lopez, Saúl Sánchez Valdez, Luis E. Cabrales Arriaga, David Victoria Valenzuela, and Hernan Peraza Vazquez
- Subjects
polypropylene ,glass fiber ,TSI-POSS ,mechanical properties ,flame retardation ,Organic chemistry ,QD241-441 - Abstract
In the present work, short glass fiber is superficially modified with different concentrations of polyhedral oligomeric silsesquioxanes (Trisilanol–Isobutyl, TSI-POSS) for processing as a filler in a polypropylene matrix (PP). It is observed that increasing the amount of TSI-POSS increases the fracture point and tensile strength; the opposite is the case for the strength impact property. The behaviors of both dynamic mechanical and thermal analyses are also observed. The flame behavior, i.e., the burning rate, decreases with increasing TSI-POSS in the polymers.
- Published
- 2024
- Full Text
- View/download PDF
113. Social and Emotional Competencies as Predictors of Student Engagement in Youth: A Cross-Cultural Multilevel Study
- Author
-
Santos, Anabela Caetano, Arriaga, Patrícia, Daniel, João R., Cefai, Carmel, Melo, Márcia H. S., Psyllou, Agoritsa, Shieh, Jin-Jy, Schutte, Nicola, Furtado, Crispiniano, David, Celso H., Azevedo, Manecas C., Andreou, Eleni, and Simões, Celeste
- Abstract
Student engagement research in university students has been scarce, despite its major positive role on performance, degree completion and mental health. Social and emotional competencies, which are currently called twenty-first-century skills, exert some impact on student engagement in youth. Since engagement is cultural-sensitive, individual (social and emotional competencies) and cross-cultural (human developmental index and unemployment rate) characteristics were examined in association with student engagement in youth. This study included 2,092 participants from nine countries/regions, aged between 17 and 27 years (M = 21.52, SD = 2.27), mostly cisgender woman (n = 1,035, 68.7%) and undergraduate (n = 1,401, 96.2%). Data were collected using a cross-sectional online survey that included the Student Engagement Scale, the Emotional Skills and Competence Questionnaire, and the prosocial behaviour/resources subscale of the Strengths and Difficulties Questionnaire. Multilevel-models showed that social and emotional competencies were relevant predictors of student engagement independently of the country-level variables. Moreover, student engagement varied with country/region human development and unemployment rate, with students from higher developed countries/regions and lowered unemployment reporting lower engagement. This study reinforces the need to implement evidence-based social and emotional learning programmes in universities worldwide, as well as public policies that can influence engagement and protect youth.
- Published
- 2023
- Full Text
- View/download PDF
114. Impact of Group Music-Making on Social Development: A Scoping Review (El impacto de la práctica musical grupal en el desarrollo social: una revisión exploratoria)
- Author
-
Cabedo-Mas, Alberto, Moliner-Miravet, Lidón, Campayo-Muñoz, Emilia, Macián-González, Roberto, and Arriaga-Sanz, Cristina
- Abstract
The potential of music-making to foster an individual's social development has been widely explored. The objective of this review is twofold: (1) to examine the characteristics of group music-making initiatives aimed at promoting social skills; and (2) to analyse the impact that group music-making initiatives have on people's social development. Twenty studies were reviewed. The aspects analysed included education level, participants' roles, participants' academic or social backgrounds, family involvement and various organizational features such as number of participants, duration of the programme, number of sessions per week and session length. Regarding the research methods used, the review explored the studies' research design, the variables analysed and the impact of the results. The results were generally positive: 79% of the qualitative studies revealed notable improvements in social skills. The average effect size for the quantitative studies ranged from large to very large. Despite these promising results, the effects of group music-making initiatives are variable. It is necessary to ensure proper implementation of the initiatives or adequate conditions to foster people's social development. [Translation from Spanish by Mercè Rius.]
- Published
- 2023
- Full Text
- View/download PDF
115. Portuguese Validation of the Cognitive Emotion Regulation Questionnaire Short Version in Youth: Validity, Reliability and Invariance across Gender and Age
- Author
-
Santos, Anabela C., Simões, Celeste, Daniel, João R., and Arriaga, Patrícia
- Abstract
The Cognitive Emotion Regulation Questionnaire (CERQ) is a multidimensional measure widely used to access nine cognitive emotion regulation strategies. In this study, we examined the psychometric properties of the CERQ-Short Portuguese version. A sample of 1052 adolescents (aged 10-25 years old, 60.53% females) completed the CERQ-Short form, the Positive and Negative Affect Schedule, the Generalized Anxiety Disorder Scale, and the Patient Health Questionnaire. Confirmatory factor analyses showed that the nine latent dimensions of CERQ-Short provided an acceptable fit to the data. Measurement invariance (for gender and three age-groups), reliability and construct validity were adequate. The adaptative strategies were positively associated with higher positive affect, and maladaptive strategies with higher negative affect, symptoms of generalized anxiety and depression. These results suggest that CERQ-Short is a valid and reliable measure for Portuguese-speaking samples. Moreover, CERQ-Short's length makes it a cost-effective tool for both clinicians and researchers.
- Published
- 2023
- Full Text
- View/download PDF
116. Empathy in Group Musical Performance: A Review of the Literature
- Author
-
Pablo Davila-Barrio, Cristina Arriaga, and Alberto Cabedo-Mas
- Abstract
Empathy plays a fundamental role in the prosocial development of young people today as an essential skill for interacting with other human beings. Music, particularly in a small group set up, offers a fitting context for its development. This article presents a review of the different studies and investigations that examine the effects that the development of empathic capacity can produce in small group instrumental practice, the capacity of empathy to induce modifications in the final result of a small group musical interpretation, and empathy and its relationship with small group musical interpretation from the field of education. The aim of this article is to review and analyse literature on how empathy is researched in the context of small group (between 2 and 10 individuals) music performance in order to enquire if the empathic ability constitutes a basic and decisive foundation in the development of multiple actions executed jointly with other individuals. For that purpose, different aspects are analysed: (1) definition of empathy and how it is measured; (2) the instruments used for its measurement; (3) the characteristics of the participants in the studies and their level of music experience; and (4) the type of activities undertaken. The analysis of the results indicates that defining empathy in this context is an ongoing process, and the concept is measured by standardised and ad hoc tests. It also shows that the type of studies and activities are related to the discipline in which they are carried out. Notably, there is a lack of studies regarding the field of study and the age and the level of musical experience of the performers.
- Published
- 2023
- Full Text
- View/download PDF
117. Her Digital World: Exploring Digital Student Engagement for Black Female Community College Students
- Author
-
Kristin J. Arriaga
- Abstract
Literature concerning student engagement and its impacts on educational attainment for Black students at community colleges is vast. The experiences of Black students at community colleges are unique, and they vary based on gender given a long history of educational discrimination and exclusion faced by Black communities. Much of the existing literature with a focus on gender focuses on the Black male experience given a recent rise in Men of Color Success Initiatives (Brooms, 2018; Brooms, 2019; Cummins, 2014). With community colleges operating in a unique space as institutions that tend to serve low-income, first-generation, and students of color, they must make an added effort to actively engage their students in ways that lead to their success (Cuellar & Gandara, 2021; Harper & Kuykendall, 2012). To address gaps in the literature, this study specifically highlights the experiences of Black female community college students. While prior scholarship has shown that overall student engagement has experienced relatively very little change, such patterns have been impacted in recent years because of the COVID-19 pandemic encouraging more colleges to shift to digitalized forms of student engagement (Mozingo, 2020). This study examined student survey data from a community college call center and defined this site as a digital platform and compares it with CCCSE data to determine if digital student engagement platforms can help foster a sense of belonging. Additionally, this study provided the language to formally define digital student engagement and to emphasize the need for student success to be inclusive of sense of belonging. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
- Published
- 2023
118. Distant Teaching: A Way to Face COVID-19 Pandemic in a Public University
- Author
-
Paredes Arriaga, Ana María, Muñoz González, Luis Fernando, and Velázquez Palmer, María Cristina Alicia
- Abstract
In México, first COVID-19 patient was identified in February and from March 23 on confinement measures were taken by the government, including the suspension of activities at universities. This paper objective is to explore the challenges that professors of a public university faced while moving into a distant teaching practice in the pandemic context. Universidad Autónoma Metropolitana is located in México City and up to the pandemic, most of its faculty lacked experience with online education, so the Emerging Distant Education Project was implemented. A qualitative design was developed and in-depth interviews were made to gather information from members of the Business Administration Faculty. Main findings show that in a short time, professors managed to redesign the courses and to develop materials, while training themselves in the use of educational platforms, videoconference and communication devices. Among positive experiences they mentioned widening their teaching skills, the positive and helpful attitudes from students, technical support from the institution and the achievement of learning objectives; while on the negative side they mentioned that math contents demanded an extra effort in order to secure students comprehension. Technical problems with the internet and the lack of a proper learning environment were cited as barriers to students' optimal academic achievement. Most of professors defined their experience as "a challenge". In conclusion, professors took on and overcame the challenges in order to continue classes and to achieve the academic objectives of the term.
- Published
- 2020
119. Objective Structured Clinical Examination (OSCE) as a Reliable Evaluation Strategy: Evidence from a Brazilian Medical School
- Author
-
Castellani, Luciana, Quintanilha, Luiz Fernando, Arriaga, Maria Belen, de Lourdes Lima, Maria, and Andrade, Bruno Bezerril
- Abstract
The new curriculum of medical schools has brought the need to develop a professional committed to ethics, capable of understanding the role of social factors, the insertion of the individual into the family and their role in promoting health. These skills and the use of new methodologies in teaching-learning process have demonstrated that the traditional performance assessment methods are limited in holistically evaluating the student. This study analyzed the correlation among different methods for evaluating competencies in medical internship students and Objective Structured Clinical Examination (OSCE). A cross-sectional, descriptive and analytical study was performed among 5th year medical students at Pediatric, Surgery, Medical Clinic, Family and Community Medicine and Gynecology and Obstetrics. Grades of each student obtained through different evaluations (theoretical test, conceptual evaluation and test skills) at the end of each rotation were correlated with the individual results from OSCE. In regard to correlations with the OSCE score values, it was found a weak to moderate positive and statistically significant relationship with the global cognitive score (r= 0.22, p< 0.001), global abilities score (r= 0.26, p< 0.001) and with the global behavioral score (r= 0.38, p< 0.001). The students' performance in the various assessments of performance evaluated here was positively correlated to their performance on OSCE. Furthermore, the organization of an OSCE-type assessment prepared in multiple, committed and competent hands may serve as a unique assessment and, in fact, assess the development of clinical skills for future doctors.
- Published
- 2020
120. Magnetic Field Computer Interface Based on Cartesian Robot for Practical Demonstration of Ampere's Law in Precollege Courses
- Author
-
Calles-Arriaga, Carlos A., López-Hernández, Juan, Hernández-Ordoñez, Martín, Nuño-Maganda, Marco A., Ortiz-Moctezuma, Manuel B., and Rocha-Rangel, Enrique
- Abstract
Basic science courses, such as physics, are fundamental to precollege studies. For instance, in different engineering applications, electricity and magnetism require comprehending subjects such as electrical circuits and power electronics. However, abstract concepts such as electric or magnetic fields are often difficult to explain without visual tools. Computer programs designed for learning physics fundamentals are useful in this area because they allow the visualization, interaction and reinforcement of main concepts in a better way than using only blackboard. In this work, an interactive MATLAB based program to visualize a magnetic field in 3D was presented. The measurements were sampled by a computer-controlled Cartesian robot with a Hall effect sensor. The magnetic field was generated by an energized electromagnet to show the relationship between electricity and magnetism. The designed graphical user interface aims to stimulate interest in electromagnetism in precollege students.
- Published
- 2022
- Full Text
- View/download PDF
121. In vitro assessment of ruminal biohydrogenation of polyunsaturated fatty acids in diets with different types and levels of protected fat and diverse sources of fibre
- Author
-
Rojas-González, Alberto Jorge, Arriaga-Jordán, Carlos Manuel, Sánchez-Torres, Juan Edrei, Mejía-Uribe, Luis Alberto, Rayas-Amor, Adolfo Armando, and Morales-Almaráz, Ernesto
- Published
- 2024
- Full Text
- View/download PDF
122. Automatic classification of depressive users on Twitter including temporal analysis
- Author
-
García-Noguez, Luis Roberto, Tovar-Arriaga, Saúl, Paredes-García, Wilfrido Jacobo, Ramos-Arreguín, Juan Manuel, and Aceves-Fernandez, Marco Antonio
- Published
- 2023
- Full Text
- View/download PDF
123. The impact of maternal morbidity on cesarean section rates: exploring a Latin American network of sentinel facilities using the Robson’s Ten Group Classification System
- Author
-
Sosa, Claudio, de Mucio, Bremen, Colomar, Mercedes, Mainero, Luis, Costa, Maria L., Guida, Jose P., Souza, Renato T., Luz, Adriana G., Cecatti, José G., Sousa, Maria H., Cruz, Carmen M., Chevez, Luz M., Lopez, Rita, Carrillo, Gema, Rizo, Ulises, Saint Hillaire, Erika E., Arriaga, William E., Guadalupe, Rosa M., Ochoa, Carlos, Gonzalez, Freddy, Castro, Rigoberto, Stefan, Allan, Moreno, Amanda, and Serruya, Suzanne J.
- Published
- 2023
- Full Text
- View/download PDF
124. The Psychological Science Accelerator’s COVID-19 rapid-response dataset
- Author
-
Buchanan, Erin M., Lewis, Savannah C., Paris, Bastien, Forscher, Patrick S., Pavlacic, Jeffrey M., Beshears, Julie E., Drexler, Shira Meir, Gourdon-Kanhukamwe, Amélie, Mallik, Peter R, Silan, Miguel Alejandro A., Miller, Jeremy K., IJzerman, Hans, Moshontz, Hannah, Beaudry, Jennifer L., Suchow, Jordan W., Chartier, Christopher R., Coles, Nicholas A., Sharifian, MohammadHasan, Todsen, Anna Louise, Levitan, Carmel A., Azevedo, Flávio, Legate, Nicole, Heller, Blake, Rothman, Alexander J., Dorison, Charles A., Gill, Brian P., Wang, Ke, Rees, Vaughan W., Gibbs, Nancy, Goldenberg, Amit, Thi Nguyen, Thuy-vy, Gross, James J., Kaminski, Gwenaêl, von Bastian, Claudia C., Paruzel-Czachura, Mariola, Mosannenzadeh, Farnaz, Azouaghe, Soufian, Bran, Alexandre, Ruiz-Fernandez, Susana, Santos, Anabela Caetano, Reggev, Niv, Zickfeld, Janis H., Akkas, Handan, Pantazi, Myrto, Ropovik, Ivan, Korbmacher, Max, Arriaga, Patrícia, Gjoneska, Biljana, Warmelink, Lara, Alves, Sara G., de Holanda Coelho, Gabriel Lins, Stieger, Stefan, Schei, Vidar, Hanel, Paul H. P., Szaszi, Barnabas, Fedotov, Maksim, Antfolk, Jan, Marcu, Gabriela-Mariana, Schrötter, Jana, Kunst, Jonas R., Geiger, Sandra J., Adetula, Adeyemi, Kocalar, Halil Emre, Kielińska, Julita, Kačmár, Pavol, Bokkour, Ahmed, Galindo-Caballero, Oscar J., Djamai, Ikhlas, Pöntinen, Sara Johanna, AGESIN, Bamikole Emmanuel, Jernsäther, Teodor, Urooj, Anum, Rachev, Nikolay R., Koptjevskaja-Tamm, Maria, Kurfalı, Murathan, Pit, Ilse L., Li, Ranran, Çoksan, Sami, Dubrov, Dmitrii, Paltrow, Tamar Elise, Baník, Gabriel, Korobova, Tatiana, Studzinska, Anna, Jiang, Xiaoming, Aruta, John Jamir Benzon R., Vintr, Jáchym, Chiu, Faith, Kaliska, Lada, Berkessel, Jana B., Tümer, Murat, Morales-Izquierdo, Sara, Chuan-Peng, Hu, Vezirian, Kevin, Rosa, Anna Dalla, Bialobrzeska, Olga, Vasilev, Martin R., Beitner, Julia, Kácha, Ondřej, Žuro, Barbara, Westerlund, Minja, Nedelcheva-Datsova, Mina, Findor, Andrej, Krupić, Dajana, Kowal, Marta, Askelund, Adrian Dahl, Pourafshari, Razieh, Đorđević, Jasna Milošević, Schmidt, Nadya-Daniela, Baklanova, Ekaterina, Szala, Anna, Zakharov, Ilya, Vranka, Marek A., Ihaya, Keiko, Grano, Caterina, Cellini, Nicola, Białek, Michał, Anton-Boicuk, Lisa, Dalgar, Ilker, Adıgüzel, Arca, Verharen, Jeroen P. H., Maturan, Princess Lovella G., Kassianos, Angelos P., Oliveira, Raquel, Čadek, Martin, Adoric, Vera Cubela, Özdoğru, Asil Ali, Sverdrup, Therese E., Aczel, Balazs, Zambrano, Danilo, Ahmed, Afroja, Tamnes, Christian K., Yamada, Yuki, Volz, Leonhard, Sunami, Naoyuki, Suter, Lilian, Vieira, Luc, Groyecka-Bernard, Agata, Kamburidis, Julia Arhondis, Reips, Ulf-Dietrich, Harutyunyan, Mikayel, Adetula, Gabriel Agboola, Allred, Tara Bulut, Barzykowski, Krystian, Antazo, Benedict G, Zsido, Andras N., Šakan, Dušana Dušan, Cyrus-Lai, Wilson, Ahlgren, Lina Pernilla, Hruška, Matej, Vega, Diego, Manunta, Efisio, Mokady, Aviv, Capizzi, Mariagrazia, Martončik, Marcel, Say, Nicolas, Filip, Katarzyna, Vilar, Roosevelt, Staniaszek, Karolina, Vdovic, Milica, Adamkovic, Matus, Johannes, Niklas, Hajdu, Nandor, Cohen, Noga, Overkott, Clara, Krupić, Dino, Hubena, Barbora, Nilsonne, Gustav, Mioni, Giovanna, Solorzano, Claudio Singh, Ishii, Tatsunori, Chen, Zhang, Kushnir, Elizaveta, Karaarslan, Cemre, Ribeiro, Rafael R., Khaoudi, Ahmed, Kossowska, Małgorzata, Bavolar, Jozef, Hoyer, Karlijn, Roczniewska, Marta, Karababa, Alper, Becker, Maja, Monteiro, Renan P., Kunisato, Yoshihiko, Metin-Orta, Irem, Adamus, Sylwia, Kozma, Luca, Czarnek, Gabriela, Domurat, Artur, Štrukelj, Eva, Alvarez, Daniela Serrato, Parzuchowski, Michal, Massoni, Sébastien, Czamanski-Cohen, Johanna, Pronizius, Ekaterina, Muchembled, Fany, van Schie, Kevin, Saçaklı, Aslı, Hristova, Evgeniya, Kuzminska, Anna O., Charyate, Abdelilah, Bijlstra, Gijsbert, Afhami, Reza, Majeed, Nadyanna M., Musser, Erica D., Sirota, Miroslav, Ross, Robert M., Yeung, Siu Kit, Papadatou-Pastou, Marietta, Foroni, Francesco, Almeida, Inês A. T., Grigoryev, Dmitry, Lewis, David M. G., Holford, Dawn L., Janssen, Steve M. J., Tatachari, Srinivasan, Batres, Carlota, Olofsson, Jonas K., Daches, Shimrit, Belaus, Anabel, Pfuhl, Gerit, Corral-Frias, Nadia Sarai, Sousa, Daniela, Röer, Jan Philipp, Isager, Peder Mortvedt, Godbersen, Hendrik, Walczak, Radoslaw B., Van Doren, Natalia, Ren, Dongning, Gill, Tripat, Voracek, Martin, DeBruine, Lisa M., Anne, Michele, Očovaj, Sanja Batić, Thomas, Andrew G., Arvanitis, Alexios, Ostermann, Thomas, Wolfe, Kelly, Arinze, Nwadiogo Chisom, Bundt, Carsten, Lamm, Claus, Calin-Jageman, Robert J, Davis, William E., Karekla, Maria, Zorjan, Saša, Jaremka, Lisa M., Uttley, Jim, Hricova, Monika, Koehn, Monica A, Kiselnikova, Natalia, Bai, Hui, Krafnick, Anthony J., Balci, Busra Bahar, Ballantyne, Tonia, Lins, Samuel, Vally, Zahir, Esteban-Serna, Celia, Schmidt, Kathleen, Macapagal, Paulo Manuel L., Szwed, Paulina, Zdybek, Przemysław Marcin, Moreau, David, Collins, W. Matthew, Joy-Gaba, Jennifer A., Vilares, Iris, Tran, Ulrich S., Boudesseul, Jordane, Albayrak-Aydemir, Nihan, Dixson, Barnaby James Wyld, Perillo, Jennifer T, Ferreira, Ana, Westgate, Erin C., Aberson, Christopher L., Arinze, Azuka Ikechukwu, Jaeger, Bastian, Butt, Muhammad Mussaffa, Silva, Jaime R., Storage, Daniel Shafik, Janak, Allison P, Jiménez-Leal, William, Soto, Jose A., Sorokowska, Agnieszka, McCarthy, Randy, Tullett, Alexa M, Frias-Armenta, Martha, Ribeiro, Matheus Fernando Felix, Hartanto, Andree, Forbes, Paul A. G., Willis, Megan L., del Carmen Tejada R, María, Torres, Adriana Julieth Olaya, Stephen, Ian D, Vaidis, David C., de la Rosa-Gómez, Anabel, Yu, Karen, Sutherland, Clare A. M., Manavalan, Mathi, Behzadnia, Behzad, Urban, Jan, Baskin, Ernest, McFall, Joseph P., Ogbonnaya, Chisom Esther, Fu, Cynthia H. Y., Rahal, Rima-Maria, Ndukaihe, Izuchukwu L. G., Hostler, Thomas J., Kappes, Heather Barry, Sorokowski, Piotr, Khosla, Meetu, Lazarevic, Ljiljana B., Eudave, Luis, Vilsmeier, Johannes K., Luis, Elkin O., Muda, Rafał, Agadullina, Elena, Cárcamo, Rodrigo A., Reeck, Crystal, Anjum, Gulnaz, Venegas, Mónica Camila Toro, Misiak, Michal, Ryan, Richard M., Nock, Nora L., Travaglino, Giovanni A., Mensink, Michael C., Feldman, Gilad, Wichman, Aaron L., Chou, Weilun, Ziano, Ignazio, Seehuus, Martin, Chopik, William J., Kung, Franki Y. H., Carpentier, Joelle, Vaughn, Leigh Ann, Du, Hongfei, Xiao, Qinyu, Lima, Tiago J. S., Noone, Chris, Onie, Sandersan, Verbruggen, Frederick, Radtke, Theda, and Primbs, Maximilian A.
- Published
- 2023
- Full Text
- View/download PDF
125. A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction
- Author
-
Queiroz, Artur T. L., Vinhaes, Caian L., Fukutani, Eduardo R., Gupte, Akshay N., Kumar, Nathella Pavan, Fukutani, Kiyoshi F., Arriaga, María B., Sterling, Timothy R., Babu, Subash, Gaikwad, Sanjay, Karyakarte, Rajesh, Mave, Vidya, Paradhkar, Mandar, Viswanathan, Vijay, Gupta, Amita, Andrade, Bruno B., and Kornfeld, Hardy
- Published
- 2023
- Full Text
- View/download PDF
126. Gestational age and sex interaction and risk for autism spectrum disorder in extremely preterm newborns: an 18‑month follow‑up study
- Author
-
L. Pina-Camacho, J. Merchan-Naranjo, E. Rodriguez-Toscano, L. Martin, C. Romero, L. Boada, S. Zeballos, M. Arriaga, and D. Blanco-Bravo
- Subjects
Psychiatry ,RC435-571 - Abstract
Introduction Extremely preterm newborns - EPTN (born ≤28 weeks gestational age) are at increased risk of developing autism spectrum disorders (ASD). Demographic and perinatal risk factors associated with ASD risk in EPTN are understudied. Objectives (i) In EPTN and born at full-term healthy controls (HC), to characterize the emergence of ASD traits and autistic symptom load at age 18 months; (ii) in EPTN, to identify the influence of perinatal characteristics such as sex and gestational age on autistic symptom load at corrected-age 18 months. Methods Observational, longitudinal, prospective, 18-month follow-up study. We recruited a cohort of n=113 EPTN and n=47 HC (the PremTEA cohort); n=57 EPTN and n=42 HC successfully completed the 18-month follow-up visit. We assessed autistic symptom load & risk at 18 months using the M-CHAT-R/F questionnaire. For all EPTN and HC, we collected demographic and perinatal data. Using GLMs, we assessed, in EPTN, the association between demographic/perinatal variables and 18-month autistic symptom levels. Results At 18 months, EPTN children showed higher autistic symptom levels than HC (M-CHAT-R/F score, mean (SD) [range] = 2.21 (3.23) [0-12] in EPTN vs. 0.33 (0.57) [0-2] in HC; d=.873, p=.001. In EPTN, we identified differences by gestational age and sex in autistic symptom levels at 18 months (aR2=0.517, p=.006). In particular, female EPTNs born with lower gestational age showed higher autistic symptom load at age 18 months. Conclusions Our findings support the need for early screening of ASD symptomatology in EPTN infants, particularly in higher-risk subgroups, such as female patients born with lower gestational ages. Disclosure of Interest None Declared
- Published
- 2024
- Full Text
- View/download PDF
127. [Untitled]
- Author
-
Alberto Jaramillo-Núñez, Mónica Pérez-Mesa, Bolivia T. Cuevas-Otahola, Jesús A. Arriaga-Hernández, and Bárbara Sánchez-Rinza
- Subjects
Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Published
- 2024
128. Levulinic to succinic acid transformation over Ru based catalysts
- Author
-
Luis Alejandro Arriaga-Arellano, Débora Álvarez-Hernández, María Isabel Domínguez, Marcela Martínez T., Anna Penkova, Svetlana Ivanova, and Miguel Ángel Centeno
- Subjects
Levulinic acid ,Oxidation ,Succinic acid ,Acetic acid ,Ruthenium ,Support nature ,Technology - Abstract
In this work ruthenium based catalysts are tested as catalytic systems for the selective oxidation of levulinic to succinic acid. Very different in nature supports have been chosen in order to elucidate the effect of their textural and acidic properties on the final catalytic activity. The influence of Ru particle size is also discussed and proposed as one of the key factors. Medium range ruthenium particles supported on relatively acid supports are the best performing systems in terms of succinic acid yield, while the most active catalysts in terms of conversion result in important carbon loss due to reagent/products full oxidation.
- Published
- 2024
- Full Text
- View/download PDF
129. Electrocardiographic approach strategies in patients with Parkinson disease treated with deep brain stimulation
- Author
-
Carlos Rafael Sierra-Fernández, Luis Rodrigo Garnica-Geronimo, Alejandra Huipe-Dimas, Jorge A. Ortega-Hernandez, María Alejandra Ruiz-Mafud, Amin Cervantes-Arriaga, Ana Jimena Hernández-Medrano, and Mayela Rodríguez-Violante
- Subjects
electrocardiography ,electrophysiology ,frequency filters ,artifact ,deep brain stimulation ,movement disorders ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Deep brain stimulation (DBS) is an interdisciplinary and reversible therapy that uses high-frequency electrical stimulation to correct aberrant neural pathways in motor and cognitive neurological disorders. However, the high frequency of the waves used in DBS can interfere with electrical recording devices (e.g., electrocardiogram, electroencephalogram, cardiac monitor), creating artifacts that hinder their interpretation. The compatibility of DBS with these devices varies and depends on factors such as the underlying disease and the configuration of the neurostimulator. In emergencies where obtaining an electrocardiogram is crucial, the need for more consensus on reducing electrical artifacts in patients with DBS becomes a significant challenge. Various strategies have been proposed to attenuate the artifact generated by DBS, such as changing the DBS configuration from monopolar to bipolar, temporarily deactivating DBS during electrocardiographic recording, applying frequency filters both lower and higher than those used by DBS, and using non-standard leads. However, the inexperience of medical personnel, variability in DBS models, or the lack of a controller at the time of approach limit the application of these strategies. Current evidence on their reproducibility and efficacy is limited. Due to the growing elderly population and the rising utilization of DBS, it is imperative to create electrocardiographic methods that are easily accessible and reproducible for general physicians and emergency services.
- Published
- 2024
- Full Text
- View/download PDF
130. Exact closed forms for the transfer matrix of free oscillations in finite periodic Timoshenko–Ehrenfest beams
- Author
-
J.C. Torres-Guzmán, A. Díaz-de-Anda, A.M. Martínez-Argüello, and J. Arriaga
- Subjects
Timoshenko–Ehrenfest beam ,Cayley–Hamilton theorem ,Transfer matrix method ,Tetranacci polynomials ,Physics ,QC1-999 - Abstract
In this work, we obtain closed-form expressions for the transfer matrix of free oscillations in finite periodic Timoshenko–Ehrenfest beams with an arbitrary number of cells. By invoking the Cayley–Hamilton theorem on the transfer matrix for free oscillations of a beam composed of N cells, we obtain a fourth-order recursive relation for the matrix coefficients, which defines the so-called Tetranacci Polynomials. Such recursive relation provides an algorithm to compute the Nth power of the transfer matrix, avoiding the matrix product of the N matrices. Furthermore, in the symmetric case of free oscillations in finite periodic Timoshenko-Ehrenfest beams, closed-form expressions for the solutions to the recursive relation have recently been derived, which we use to write the transfer matrix of a finite beam composed of N cells in a closed form. We find a good agreement between the natural frequencies calculated with the obtained expressions and finite element simulations. These expressions are very useful for studying the interaction of evanescent oscillations and find application, for instance, in the development of phononic topological insulators. Our formalism can be applied to waves propagating in finite periodic layers described by a 4 × 4-transfer matrix, such as electromagnetic waves in anisotropic optical media.
- Published
- 2024
- Full Text
- View/download PDF
131. Establishment of induced pluripotent stem cell lines derived from Parkinson’s disease Mexican patients: A sporadic (UNAMi002-A) and a familial (UNAMi003-A) case carrying a mutation in PINK1
- Author
-
Xóchitl Flores-Ponce, Adolfo López-Ornelas, Itzel Escobedo-Avila, Mayela Rodríguez-Violante, David Dávila-Ortiz de Montellano, Amín Cervantes-Arriaga, Nancy Monroy-Jaramillo, Aurelio Campos-Romo, and Iván Velasco
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results in a prominent reduction of striatal dopamine levels leading to motor alterations. The mechanisms underlying neurodegeneration in PD remain unknown. Here, we generated an induced pluripotent stem cell line from dermal fibroblasts of a Mexican patient diagnosed with sporadic PD (UNAMi002-A) and another cell line from dermal fibroblasts of a patient carrying the point mutation c.1423delC in PINK1 (UNAMi003-A). These patient-derived iPS cell lines offer the possibility of modeling PD and understanding the mechanisms that contribute to dopamine neuron loss.
- Published
- 2024
- Full Text
- View/download PDF
132. Social prescribing for older adults in mainland Portugal: Perceptions and future prospects
- Author
-
Andreia Costa, Joana Henriques, Violeta Alarcão, Teresa Madeira, Ana Virgolino, Adriana Henriques, Rodrigo Feteira-Santos, Marie Polley, Miguel Arriaga, and Paulo Nogueira
- Subjects
Social prescribing ,Older adults ,Quality of life ,Person-centered ,Portugal ,Medicine - Abstract
Background: In order to address health inequalities, which have been exacerbated by the COVID-19 pandemic, and promote older adults’ quality of life, it is necessary to explore non-medical approaches such as social prescribing. Social prescribing is a person-centered approach that allows health professionals to refer patients to services provided by the social and community sectors. This study aimed to explore older adults' perceptions of social prescribing in mainland Portugal and to identify factors associated with these perceptions, providing insights for future implementation strategies. Methods: A cross-sectional study was conducted with 613 older adults aged 65 to 93. Participants' sociodemographic, economic, and health characteristics were assessed, along with their perceptions of social prescribing’s benefits and activity interest. Results: Over 75% of respondents agreed that social prescribing would benefit the health system and their community. Most participants (87.7% and 89.7%, respectively) thought that activities like personal protection and development activities and cultural enrichment would be particularly relevant to them. Factors such as marital status, education, health status, and pain/discomfort levels influenced the perceived relevance of these activities. Conclusion: This study reveals that older adults in mainland Portugal are open to social prescribing and suggests that tailored interventions considering individual preferences and characteristics can lead to more effective implementation and equal access to social prescribing. Further research and policy efforts should focus on integrating social prescribing into the healthcare system to support healthy aging in Portugal.
- Published
- 2024
- Full Text
- View/download PDF
133. Finite size effects and optimization of the calculation of the surface tension in surfactant mixtures at liquid/vapour interfaces
- Author
-
C. J. Guzman-Valencia, J. Toriz-Salinas, H. Espinosa-Jimenez, A. B. Salazar-Arriaga, J. L. López-Cervantes, and H. Dominguez
- Subjects
finite size effects ,molecular dynamics ,surface tension ,surfactant monolayer mixtures ,water/air ,Physics ,QC1-999 - Abstract
The surface tension of monolayers with mixtures of anionic and nonionic surfactant at the liquid/vapour interface is studied. Previous works have observed that calculations of the surface tension of simple fluids show artificial oscillations for small interfacial areas, indicating that the surface tension data fluctuate due to the finite size effects and periodic boundary conditions. In the case of simulations of monolayers composed of surfactant mixtures, the surface tension not only oscillates for small areas but can also give non-physical data, such as negative values. Analysis of the monolayers with different surfactant mixtures, ionic (DTAB, CTAB, SDS) and nonionic (SB3-12), was done for density profiles, parameters of order and pair correlation functions for small and large box areas and all of them present similar behaviour. The fluctuations and the non-physical values of the surface tension are corrected when boxes with large interfacial areas are considered. The results indicate that in order to obtain reliable values of the surface tension, in computer simulations, it is important to choose not only the correct force field but also the appropriate size of the simulation box.
- Published
- 2024
- Full Text
- View/download PDF
134. Enseñanza de programación para niños y jóvenes con discapacidad visual: mapeo sistemático de la literatura
- Author
-
Raúl Arturo Peredo-Estudillo, Juan Carlos Pérez Arriaga, Gerardo Contreras-Vega, and Ángel J. Sánchez-García
- Subjects
Discapacidad visual ,Personas ciegas ,Programación ,Enseñanza ,Accesibilidad ,Mapeo sistemático ,Computer engineering. Computer hardware ,TK7885-7895 - Abstract
En la actualidad la educación de los estudiantes se enfoca en las disciplinas Ciencia, Tecnología, Ingeniería y Matemáticas (modelo integral STEM por sus siglas en ingles). Una estrategia efectiva para incorporar la ingeniería y la tecnología en la educación es promover el pensamiento computacional, donde la programación desempeña un papel fundamental en el desarrollo de habilidades lógicas y del pensamiento lógico estructurado. Sin embargo, es esencial destacar que las personas con discapacidad visual enfrentan desafíos específicos para adquirir estas competencias. El propósito de esta investigación es llevar a cabo un mapeo sistemático de la literatura con el fin de analizar los métodos, técnicas y herramientas utilizados para enseñar programación a niños y jóvenes con discapacidad visual. En este artículo, se exponen los resultados del mapeo sistemático de la literatura en el que se seleccionaron un total de 23 estudios. Los principales hallazgos incluyeron cinco métodos: aprendizaje háptico, resolución de casos, trabajo en equipo, enseñanza activa y enfoque basado en problemas. En cuanto a las técnicas, se identificaron cinco: basadas en tecnología, interactivas, basadas en juegos, en parejas y colaborativas. Para concluir, se encontraron cuatro tipos de herramientas: asistidas, hápticas basadas en audio y lectores de pantalla.
- Published
- 2024
135. Effectiveness of a diagnostic algorithm for dengue based on an artificial neural network
- Author
-
Carmen Alicia Ruiz Valdez, Olga María Alejo Martínez, Brenda Leticia Rocha Reyes, Porfirio Felipe Hernández Bautista, David Alejandro Cabrera Gaytán, Alfonso Vallejos Parás, Lumumba Arriaga Nieto, Leticia Jaimes Betancourt, Alejandro Moctezuma Paz, Mónica Grisel Rivera Mahey, Gabriel Valle Alvarado, and Brenda Ivett Velez García
- Subjects
Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Introduction Dengue is a disease with a wide clinical spectrum. The early identification of dengue cases is crucial but challenging for health professionals; therefore, it is necessary to have effective diagnostic instruments to initiate timely care. Objective To evaluate the effectiveness of an algorithm based on an artificial neural network (ANN) to diagnose dengue in an endemic area. Methods A single-center case–control study was conducted in a secondary-care hospital in Ciudad Obregón, Sonora. An algorithm was built with the official operational definitions, which was called the “direct algorithm,” and for the ANN algorithm, the brain.js library was used. The data analysis was performed with the diagnostic tests of sensitivity, specificity, positive predictive value (ppv), and negative predictive value (npv), with 95% confidence intervals and Cohen's kappa index. Results A total of 233 cases and 233 controls from 2022 were included. The ANN presented a sensitivity of 0.90 (95% CI [0.85, 0.94]), specificity of 0.82 (95% CI [0.77, 0.87]), npv of 0.91 (95% CI [0.87, 0.94]) and ppv of 0.81 (95% CI [0.76, 0.85]) and a kappa of 0.72. The direct algorithm had a sensitivity of 0.97 (95% CI [0.94, 0.99]), specificity of 0.96 (95% CI [0.92, 0.98]), npv 0.97 (95% CI [0.94, 0.98]), ppv 0.96 (95% CI [0.93, 0.98]) and kappa 0.93. Conclusions The direct algorithm performed better than the ANN in the diagnosis of dengue.
- Published
- 2024
- Full Text
- View/download PDF
136. An integrative multi-omics approach to characterize interactions between tuberculosis and diabetes mellitus
- Author
-
Caian L. Vinhaes, Eduardo R. Fukutani, Gabriel C. Santana, María B. Arriaga, Beatriz Barreto-Duarte, Mariana Araújo-Pereira, Mateus Maggiti-Bezerril, Alice M.S. Andrade, Marina C. Figueiredo, Ginger L. Milne, Valeria C. Rolla, Afrânio L. Kristki, Marcelo Cordeiro-Santos, Timothy R. Sterling, Bruno B. Andrade, and Artur T.L. Queiroz
- Subjects
Bioinformatics ,Biological sciences ,Health sciences ,Internal medicine ,Medical informatics ,Medical specialty ,Science - Abstract
Summary: Tuberculosis-diabetes mellitus (TB-DM) is linked to a distinct inflammatory profile, which can be assessed using multi-omics analyses. Here, a machine learning algorithm was applied to multi-platform data, including cytokines and gene expression in peripheral blood and eicosanoids in urine, in a Brazilian multi-center TB cohort. There were four clinical groups: TB-DM(n = 24), TB only(n = 28), DM(HbA1c ≥ 6.5%) only(n = 11), and a control group of close TB contacts who did not have TB or DM(n = 13). After cross-validation, baseline expression or abundance of MMP-28, LTE-4, 11-dTxB2, PGDM, FBXO6, SECTM1, and LINCO2009 differentiated the four patient groups. A distinct multi-omic-derived, dimensionally reduced, signature was associated with TB, regardless of glycemic status. SECTM1 and FBXO6 mRNA levels were positively correlated with sputum acid-fast bacilli grade in TB-DM. Values of the biomarkers decreased during the course of anti-TB therapy. Our study identified several markers associated with the pathophysiology of TB-DM that could be evaluated in future mechanistic investigations.
- Published
- 2024
- Full Text
- View/download PDF
137. Microbiota modulation by dietary oat beta-glucan prevents steatotic liver disease progression
- Author
-
Julius W. Jaeger, Annette Brandt, Wenfang Gui, Timur Yergaliyev, Angélica Hernández-Arriaga, Mukil Marutha Muthu, Karolina Edlund, Ahmed Elashy, Antonio Molinaro, Diana Möckel, Jan Sarges, Emina Halibasic, Michael Trauner, Florian Kahles, Ulrike Rolle-Kampczyk, Jan Hengstler, Carolin Victoria Schneider, Twan Lammers, Hanns-Ulrich Marschall, Martin von Bergen, Amélia Camarinha-Silva, Ina Bergheim, Christian Trautwein, and Kai Markus Schneider
- Subjects
MASLD ,beta-glucan ,microbiota ,fibrosis ,gut-liver axis ,prebiotics ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background & Aims: Changes in gut microbiota in metabolic dysfunction-associated steatotic liver disease (MASLD) are important drivers of disease progression towards fibrosis. Therefore, reversing microbial alterations could ameliorate MASLD progression. Oat beta-glucan, a non-digestible polysaccharide, has shown promising therapeutic effects on hyperlipidemia associated with MASLD, but its impact on gut microbiota and most importantly MASLD-related fibrosis remains unknown. Methods: We performed detailed metabolic phenotyping, including assessments of body composition, glucose tolerance, and lipid metabolism, as well as comprehensive characterization of the gut-liver axis in a western-style diet (WSD)-induced model of MASLD and assessed the effect of a beta-glucan intervention on early and advanced liver disease. Gut microbiota were modulated using broad-spectrum antibiotic treatment. Results: Oat beta-glucan supplementation did not affect WSD-induced body weight gain or glucose intolerance and the metabolic phenotype remained largely unaffected. Interestingly, oat beta-glucan dampened MASLD-related inflammation, which was associated with significantly reduced monocyte-derived macrophage infiltration and fibroinflammatory gene expression, as well as strongly reduced fibrosis development. Mechanistically, this protective effect was not mediated by changes in bile acid composition or signaling, but was dependent on gut microbiota and was lost upon broad-spectrum antibiotic treatment. Specifically, oat beta-glucan partially reversed unfavorable changes in gut microbiota, resulting in an expansion of protective taxa, including Ruminococcus, and Lactobacillus followed by reduced translocation of Toll-like receptor ligands. Conclusions: Our findings identify oat beta-glucan as a highly efficacious food supplement that dampens inflammation and fibrosis development in diet-induced MASLD. These results, along with its favorable dietary profile, suggest that it may be a cost-effective and well-tolerated approach to preventing MASLD progression and should be assessed in clinical studies. Impact and Implications: Herein, we investigated the effect of oat beta-glucan on the gut-liver axis and fibrosis development in a mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD). Beta-glucan significantly reduced inflammation and fibrosis in the liver, which was associated with favorable shifts in gut microbiota that protected against bacterial translocation and activation of fibroinflammatory pathways. Together, oat beta-glucan may be a cost-effective and well-tolerated approach to prevent MASLD progression and should be assessed in clinical studies.
- Published
- 2024
- Full Text
- View/download PDF
138. Análisis de la producción de café (Coffea arabica L.), en Amatepec, Estado de México
- Author
-
Gabriel Leguizamo-Sotelo, Martha Lidya Salgado-Siclán, and Martín Rubí-Arriaga
- Subjects
Cafeticultores ,caracterización ,descripción ,marginal ,pequeños productores ,Agriculture - Abstract
El municipio de Amatepec con una superficie plantada de 338 hectáreas es el principal productor de café en el Estado de México, con la participación de 230 productores tiene un volumen de producción de 393 toneladas. Con el objetivo de conocer las características socioeconómicas, económicas, agronómicas y culturales de los cafeticultores para establecer un análisis de la producción en el municipio, entre diciembre de 2021 y marzo del 2022 se llevó a cabo el levantamiento de la información en 18 localidades, mediante una entrevista aplicada a 80 productores, considerando un muestreo probabilístico. Se evaluaron 36 variables divididas en los cuatro aspectos anteriormente señalados. El promedio de edad fue de 56.07 años, predominan los hombres (81.2%), el 30% de los entrevistados tienen licenciatura y el 11% de estos son profesores (primaria). El 46.3% vende el café como molido, entre $180.00 y $250.00 pesos kilogramo, así el 92.4% de la producción se destina para el mercado local. Un 55.9% de los productores obtienen rendimientos menores a 2 000 kg·ha-1, con ingresos de $10 001.00 a $100 000.00 pesos anuales (55.8%). Más del 83.6% cultivan la variedad Típica, con diversidad de marcos y densidades de plantación, un 31.2% de las plantaciones poseen una edad mayor a 31 años. El 95% está interesado en recibir cursos de capacitación, a pesar de que el 66.2% ha recibido algún tipo de adiestramiento. Para algunos de ellos, el café es la única fuente de ingreso, cuya fortaleza distintiva es la altitud.
- Published
- 2024
- Full Text
- View/download PDF
139. Blood Flow Restriction Training for Meniscus Repair Surgery
- Author
-
Yuki Yamanashi MD, Sachin Allahabadi MD, C. Benjamin Ma MD, and Ivan Arriaga DPT
- Subjects
Sports medicine ,RC1200-1245 ,Orthopedic surgery ,RD701-811 - Abstract
Background: Blood flow restriction (BFR) is a training tool that involves wearing a tourniquet or occlusive device during exercise. Data support that low-load training with BFR may produce muscle hypertrophy similar to standard high-load training. Because of the weight-bearing and range of motion (ROM) restrictions after meniscal repair, patients encounter substantial atrophy of lower extremity musculature. We perform BFR for these patients to limit atrophy postoperatively with the goal of facilitating their return to prior function and sports. Indications: We incorporate BFR in the postoperative rehabilitation protocol for patients undergoing meniscal repair not involving the root. Patients with the following are excluded: acute or severe cardiac disease, peripheral vascular disease, blood pressure over systolic 180 mm Hg or diastolic 100 mm Hg, hemophilia, thrombophlebitis or history of deep vein thrombosis, severe anemia, and sickle cell disease. Technique Description: An automated BFR device calculates the patient’s limb occlusion pressure (LOP) and titrates to 50% to 80% of LOP for lower extremity exercises. Exercise parameters typically consist of 4 sets of each exercise, totaling 75 repetitions, with 30-second interset rest. Patients undergo a standard 3-phase postoperative rehabilitation protocol. Phase I (weeks 0-6): Patients are nonweightbearing, may be either footflat weightbearing or partial weightbearing at the surgeon’s, with ROM restricted 0 to 90 in a hinge knee brace throughout the phase. Exercises include quadriceps sets with neuromuscular electrical stimulation and straight leg raises and short/long arcs quadriceps. Phase II (weeks 7-8): Patients progress to weightbearing and ROM as tolerated and begin exercises including double mini squats, hamstring curls, double leg press, and double leg heel raises. Phase III: (weeks 9+): Patients perform double and single leg bridges, double leg bridges on ball with knee band, squats, single leg press, and single leg heel raises, all with the goal of returning to sports. Results: Prior systematic review data demonstrate low-load training with BFR increases muscle strength and induces hypertrophy relative to low-load training alone. No significant differences for Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales between BFR training group and control group. Discussion: BFR training may facilitate postoperative recovery in patients undergoing meniscal repair surgery by helping mitigate muscular atrophy. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
- Published
- 2024
- Full Text
- View/download PDF
140. Functional impact of multi-omic interactions in lung cancer
- Author
-
Miguel Ángel Díaz-Campos, Jorge Vasquez-Arriaga, Soledad Ochoa, and Enrique Hernández-Lemus
- Subjects
lung adenocarcinoma ,lung squamous cell carcinoma ,multiomics ,mutual information ,network construction ,computational analysis ,Genetics ,QH426-470 - Abstract
Lung tumors are a leading cause of cancer-related death worldwide. Lung cancers are highly heterogeneous on their phenotypes, both at the cellular and molecular levels. Efforts to better understand the biological origins and outcomes of lung cancer in terms of this enormous variability often require of high-throughput experimental techniques paired with advanced data analytics. Anticipated advancements in multi-omic methodologies hold potential to reveal a broader molecular perspective of these tumors. This study introduces a theoretical and computational framework for generating network models depicting regulatory constraints on biological functions in a semi-automated way. The approach successfully identifies enriched functions in analyzed omics data, focusing on Adenocarcinoma (LUAD) and Squamous cell carcinoma (LUSC, a type of NSCLC) in the lung. Valuable information about novel regulatory characteristics, supported by robust biological reasoning, is illustrated, for instance by considering the role of genes, miRNAs and CpG sites associated with NSCLC, both novel and previously reported. Utilizing multi-omic regulatory networks, we constructed robust models elucidating omics data interconnectedness, enabling systematic generation of mechanistic hypotheses. These findings offer insights into complex regulatory mechanisms underlying these cancer types, paving the way for further exploring their molecular complexity.
- Published
- 2024
- Full Text
- View/download PDF
141. A Deep Polarimetric Study of the Asymmetrical Debris Disk HD 106906
- Author
-
Crotts, Katie A., Matthews, Brenda C., Esposito, Thomas M., Duchêne, Gaspard, Kalas, Paul, Chen, Christine H., Arriaga, Pauline, Millar-Blanchaer, Maxwell A., Debes, John H., Draper, Zachary H., Fitzgerald, Michael P., Hom, Justin, MacGregor, Meredith A., Mazoyer, Johan, Patience, Jennifer, Rice, Malena, Weinberger, Alycia J., Wilner, David J., and Wolff, Schuyler
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
HD 106906 is a young, binary stellar system, located in the Lower Centaurus Crux (LCC) group. This system is unique among discovered systems in that it contains an asymmetrical debris disk, as well as an 11 M$_{Jup}$ planet companion, at a separation of $\sim$735 AU. Only a handful of other systems are known to contain both a disk and directly imaged planet, where HD 106906 is the only one in which the planet has apparently been scattered. The debris disk is nearly edge on, and extends roughly to $>$500 AU, where previous studies with HST have shown the outer regions to have high asymmetry. To better understand the structure and composition of the disk, we have performed a deep polarimetric study of HD 106906's asymmetrical debris disk using newly obtained $H$-, $J$-, and $K1$-band polarimetric data from the Gemini Planet Imager (GPI). An empirical analysis of our data supports a disk that is asymmetrical in surface brightness and structure, where fitting an inclined ring model to the disk spine suggests that the disk may be highly eccentric ($e\gtrsim0.16$). A comparison of the disk flux with the stellar flux in each band suggests a blue color that also does not significantly vary across the disk. We discuss these results in terms of possible sources of asymmetry, where we find that dynamical interaction with the planet companion, HD 106906b, is a likely candidate., Comment: 19 pages, 10 figures, 4 tables, accepted for publication in ApJ
- Published
- 2021
- Full Text
- View/download PDF
142. Synthesis and Characterization of Nd:YAG Ceramics for Laser Applications
- Author
-
Olga Alondra Echartea-Reyes, Gloria Verónica Vázquez, José Adalberto Castillo-Robles, Juan López-Hernández, Carlos Adrián Calles-Arriaga, Wilian Jesús Pech-Rodríguez, and Enrique Rocha-Rangel
- Subjects
Nd-YAG ,laser ,optical characterization ,Technology ,Chemical technology ,TP1-1185 - Abstract
Materials known as Nd:YAG are crystalline materials of the cubic system made from the neodymium-doped yttrium aluminum garnet, which, among others, have excellent optical properties. Nd:YAG four-level laser devices are frequently used in both the health and industrial sectors. In this study, a simple and inexpensive alternative to manufacturing Nd:YAG materials through solid state reactions following powder processing routes was proposed. For this, an intense mixture of the precursor materials (Al2O3 and Y2O3) was carried out, followed by the addition of neodymium atoms to improve the optical properties of the resulting material. High-energy mechanical mixing of the precursor powders resulted in submicron particles with good size distributions of the powders. The advance of YAG formation was monitored by intermediate phase formation during heat treatment through interrupted tests at different temperatures and analysis by X-ray diffraction. From this analysis, it was found that reaction for the formation of the desired YAG is completed at 1500 °C. Fourier transform infrared spectroscopy analyses determined the presence of functional groups corresponding to the YAG. Finally, the study employing optical emission spectroscopy showed wavelengths in agreement with those of the electronic structure of the elements of the synthesized Nd:YAG.
- Published
- 2023
- Full Text
- View/download PDF
143. The impact of maternal morbidity on cesarean section rates: exploring a Latin American network of sentinel facilities using the Robson’s Ten Group Classification System
- Author
-
Claudio Sosa, Bremen de Mucio, Mercedes Colomar, Luis Mainero, Maria L. Costa, Jose P. Guida, Renato T. Souza, Adriana G. Luz, José G. Cecatti, Maria H. Sousa, Carmen M. Cruz, Luz M. Chevez, Rita Lopez, Gema Carrillo, Ulises Rizo, Erika E. Saint Hillaire, William E. Arriaga, Rosa M. Guadalupe, Carlos Ochoa, Freddy Gonzalez, Rigoberto Castro, Allan Stefan, Amanda Moreno, and Suzanne J. Serruya
- Subjects
Severe maternal morbidity ,Cesarean section ,Robson classification ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Latin America has the highest Cesarean Section Rates (CSR) in the world. Robson’s Ten Group Classification System (RTGCS) was developed to enable understanding the CSR in different groups of women, classified according to obstetric characteristics into one of ten groups. The size of each CS group may provide helpful data on quality of care in a determined region or setting. Data can potentially be used to compare the impact of conditions such as maternal morbidity on CSR. The objective of this study is to understand the impact of Severe Maternal Morbidity (SMM) on CSR in ten different groups of RTGCS. Methods Secondary analysis of childbirth information from 2018 to 2021, including 8 health facilities from 5 Latin American and Caribbean countries (Bolivia, Guatemala, Honduras, Nicaragua, and the Dominican Republic), using a surveillance database (SIP-Perinatal Information System, in Spanish) implemented in different settings across Latin America. Women were classified into one of RTGCS. The frequency of each group and its respective CSR were described. Furthermore, the sample was divided into two groups, according to maternal outcomes: women without SMM and those who experienced SMM, considering Potentially Life-threatening Conditions, Maternal Near Miss and Maternal Death as the continuum of morbidity. Results Available data were obtained from 92,688 deliveries using the Robson Classification. Overall CSR was around 38%. Group 5 was responsible for almost one-third of cesarean sections. SMM occurred in 6.7% of cases. Among these cases, the overall CSR was almost 70% in this group. Group 10 had a major role (preterm deliveries). Group 5 (previous Cesarean section) had a very high CSR within the group, regardless of the occurrence of maternal morbidity (over 80%). Conclusion Cesarean section rate was higher in women experiencing SMM than in those without SMM in Latin America. SMM was associated with higher Cesarean section rates, especially in groups 1 and 3. Nevertheless, group 5 was the major contributor to the overall CSR.
- Published
- 2023
- Full Text
- View/download PDF
144. Ethics 4.0: Ethical Dilemmas in Healthcare Mediated by Social Robots
- Author
-
Soares, Antonio, Piçarra, Nuno, Giger, Jean-Christophe, Oliveira, Raquel, and Arriaga, Patrícia
- Published
- 2023
- Full Text
- View/download PDF
145. Liger for Next Generation Keck AO: Filter Wheel and Pupil Design
- Author
-
Cosens, Maren, Wright, Shelley A., Arriaga, Pauline, Brown, Aaron, Fitzgerald, Michael, Jones, Tucker, Kassis, Marc, Kress, Evan, Kupke, Renate, Larkin, James E., Lyke, Jim, Wang, Eric, Wiley, James, and Yeh, Sherry
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Liger is a next-generation near-infrared imager and integral field spectrograph (IFS) for the W.M. Keck Observatory designed to take advantage of the Keck All-Sky Precision Adaptive Optics (KAPA) upgrade. Liger will operate at spectral resolving powers between R$\sim$4,000 - 10,000 over a wavelength range of 0.8-2.4$\mu$m. Liger takes advantage of a sequential imager and spectrograph design that allows for simultaneous observations between the two channels using the same filter wheel and cold pupil stop. We present the design for the filter wheels and pupil mask and their location and tolerances in the optical design. The filter mechanism is a multi-wheel design drawing from the heritage of the current Keck/OSIRIS imager single wheel design. The Liger multi-wheel configuration is designed to allow future upgrades to the number and range of filters throughout the life of the instrument. The pupil mechanism is designed to be similarly upgradeable with the option to add multiple pupil mask options. A smaller wheel mechanism allows the user to select the desired pupil mask with open slots being designed in for future upgrade capabilities. An ideal pupil would match the shape of the image formed of the primary and would track its rotation. For different pupil shapes without tracking we model the additional exposure time needed to achieve the same signal to noise of an ideal pupil and determine that a set of fixed masks of different shapes provides a mechanically simpler system with little compromise in performance., Comment: 9 pages, 7 figures, 1 table
- Published
- 2021
- Full Text
- View/download PDF
146. Rapid Convergence: The Outcomes of Making PPE during a Healthcare Crisis
- Author
-
Mack, Kelly, Hofmann, Megan, Lakshmi, Udaya, Cao, Jerry, Auradkar, Nayha, Arriaga, Rosa I., Hudson, Scott E., and Mankoff, Jennifer
- Subjects
Computer Science - Human-Computer Interaction - Abstract
The NIH 3D Print Exchange is a public and open source repository for primarily 3D printable medical device designs with contributions from expert-amateur makers, engineers from industry and academia, and clinicians. In response to the COVID-19 pandemic, a collection was formed to foster submissions of low-cost, local manufacture of personal protective equipment (Personal Protective Equipment (PPE)). We systematically evaluated the 623 submissions in this collection to understand: what makers contributed, how they were made, who made them, and key characteristics of their designs. Our analysis reveals an immediate design convergence to derivatives of a few initial designs affiliated with NIH partners (e.g., universities, the Veteran's Health Administration, America Makes) and major for-profit groups (e.g., Prusa). The NIH worked to review safe and effective designs but was quickly overloaded by derivative works. We found that the vast majority were never reviewed (81.3%) while 10.4% of those reviewed were deemed safe for clinical (5.6%) or community use (4.8%). Our work contributes insights into: the outcomes of distributed, community-based, medical making; features the community accepted as "safe" making; and how platforms can support regulated maker activities in high-risk domains (e.g., healthcare).
- Published
- 2021
147. Perspective of Water-Use Programs in Agriculture in Guanajuato
- Author
-
Jesús Hernández-Ruiz, Paula C. Isiordia-Lachica, Ilse A. Huerta-Arredondo, Ana M. Cruz-Avalos, Arturo Ángel Hernández, Ricardo A. Rodriguez-Carvajal, Jorge E. Ruiz-Nieto, and Ana I. Mireles-Arriaga
- Subjects
water resource allocation ,water budgetary programs ,groundwater management availability ,Agriculture (General) ,S1-972 - Abstract
Integrated agricultural water management (IAWM) encompasses multiple factors, necessitating the evaluation of performance across programs and involved entities and local consideration in different regions. This study analyzes the relation of allocation budgets and government agency programs in relation to the average annual availability of groundwater in Guanajuato State. Documentary investigation was conducted on public programs, aquifer availability, and agricultural land types over the period from 2017 to 2023. In the last six years, the amounts allocated to government programs from subsidies and donations have increased by 40%, leading to enhanced agricultural productivity in the state. Considering the agricultural types (rain-fed, irrigated, and protected) as separate variables, simple linear regression explains 97.8% of the variability in the DMA, indicating a decrease of 78.2 million m3 and an increase in irrigated agriculture. The estimator for the budget allocated to public programs is −2.21 × 10−7, indicating that even if the resources allocated to government programs related to the use and exploitation of water in the agricultural sector increase, the DMA will continue to decrease. Regarding the agriculture area type, the estimator has a value of −0.00237, indicating that each rain-fed or irrigated agriculture unit established would result in an approximate reduction of 2370 m3 of water in the DMA. Taking this into account, it is imperative to formulate strategies that consider intersectoral links, with a focus on prioritizing essential actions in rain-fed areas for water capture and/or irrigated agricultural areas for food production, which comprise 52% of the total land dedicated to the agricultural sector, and specifically targeting actions that promote groundwater management.
- Published
- 2024
- Full Text
- View/download PDF
148. The Expression Profiles of lncRNAs Are Associated with Neoadjuvant Chemotherapy Resistance in Locally Advanced, Luminal B-Type Breast Cancer
- Author
-
Miguel González-Woge, Laura Contreras-Espinosa, José Antonio García-Gordillo, Sergio Aguilar-Villanueva, Enrique Bargallo-Rocha, Paula Cabrera-Galeana, Tania Vasquez-Mata, Ximena Cervantes-López, Diana Sofía Vargas-Lías, Rogelio Montiel-Manríquez, Luis Bautista-Hinojosa, Rosa Rebollar-Vega, Clementina Castro-Hernández, Rosa María Álvarez-Gómez, Inti Alberto De La Rosa-Velázquez, José Díaz-Chávez, Francisco Jiménez-Trejo, Cristian Arriaga-Canon, and Luis Alonso Herrera
- Subjects
lncRNA ,luminal B ,breast cancer ,transcriptome ,predictive biomarker ,neoadjuvant chemotherapy ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
lncRNAs are noncoding transcripts with tissue and cancer specificity. Particularly, in breast cancer, lncRNAs exhibit subtype-specific expression; they are particularly upregulated in luminal tumors. However, no gene signature-based laboratory tests have been developed for luminal breast cancer identification or the differential diagnosis of luminal tumors, since no luminal A- or B-specific genes have been identified. Particularly, luminal B patients are of clinical interest, since they have the most variable response to neoadjuvant treatment; thus, it is necessary to develop diagnostic and predictive biomarkers for these patients to optimize treatment decision-making and improve treatment quality. In this study, we analyzed the lncRNA expression profiles of breast cancer cell lines and patient tumor samples from RNA-Seq data to identify an lncRNA signature specific for luminal phenotypes. We identified an lncRNA signature consisting of LINC01016, GATA3-AS1, MAPT-IT1, and DSCAM-AS1 that exhibits luminal subtype-specific expression; among these lncRNAs, GATA3-AS1 is associated with the presence of residual disease (Wilcoxon test, p < 0.05), which is related to neoadjuvant chemotherapy resistance in luminal B breast cancer patients. Furthermore, analysis of GATA3-AS1 expression using RNA in situ hybridization (RNA ISH) demonstrated that this lncRNA is detectable in histological slides. Similar to estrogen receptors and Ki67, both commonly detected biomarkers, GATA3-AS1 proves to be a suitable predictive biomarker for clinical application in breast cancer laboratory tests.
- Published
- 2024
- Full Text
- View/download PDF
149. Recent Advances in Metal Complexes Based on Biomimetic and Biocompatible Organic Ligands against Leishmaniasis Infections: State of the Art and Alternatives
- Author
-
Sandra Jimenez-Falcao and Jose Manuel Mendez-Arriaga
- Subjects
parasite ,leishmania ,neglected diseases ,metal complex ,metal nanoparticle ,Inorganic chemistry ,QD146-197 - Abstract
Leishmaniasis is a complex disease present in a variety of manifestations listed by the World Health Organization (WHO) as one of the neglected diseases with a worse prognosis if not treated. Medicinal inorganic chemistry has provided a variety of drugs based on metal–organic complexes synthesized with different metal centers and organic ligands to fight against a great number of parasite maladies and specifically Leishmaniasis. Taking advantage of the natural properties that many metals present for biotechnological purposes, nanotechnology has offered, in recent years, a new approach consisting on the application of metal nanoparticles to treat a great number of parasitic diseases, as a drug vehicle or as a treatment themselves. The aim of this review is to gather the most widely used metal complexes and metallic nanoparticles and the most recent strategies proposed as antileishmanial agents.
- Published
- 2024
- Full Text
- View/download PDF
150. Recent Progress in Creep-Resistant Aluminum Alloys for Diesel Engine Applications: A Review
- Author
-
Raul Irving Arriaga-Benitez and Mihriban Pekguleryuz
- Subjects
second phase ,Al alloy ,creep ,heavy vehicle ,diesel engine component ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Diesel engines in heavy-duty vehicles are predicted to maintain a stable presence in the future due to the difficulty of electrifying heavy trucks, mine equipment, and railway cars. This trend encourages the effort to develop new aluminum alloy systems with improved performance at diesel engine conditions of elevated temperature and stress combinations to reduce vehicle weight and, consequently, CO2 emissions. Aluminum alloys need to provide adequate creep resistance at ~300 °C and room-temperature tensile properties better than the current commercial aluminum alloys used for powertrain applications. The studies for improving creep resistance for aluminum casting alloys indicate that their high-temperature stability depends on the formation of high-density uniform dispersoids with low solid solubility and low diffusivity in aluminum. This review summarizes three generations of diesel engine aluminum alloys and focuses on recent work on the third-generation dispersoid-strengthened alloys. Additionally, new trends in developing creep resistance through the development of alloy systems other than Al-Si-based alloys, the optimization of manufacturing processes, and the use of thermal barrier coatings and composites are discussed. New progress on concepts regarding the thermal stability of rapidly solidified and nano-structured alloys and on creep-resistant alloy design via machine learning-based algorithms is also presented.
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.