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101. Prolonged Phenotypic, Functional, and Molecular Change in Group I Burkitt Lymphoma Cells on Short-Term Exposure to CD40 Ligand

Author

Christopher D. Gregory, Aristides G. Eliopoulos, Richard J. Armitage, John Gordon, Matthew P. Baker, and Lawrence S. Young

Subjects
Programmed cell death, CD40, Cell division, Cell growth, Immunology, Cell Biology, Hematology, Biology, Cell morphology, Molecular biology, Biochemistry, Antigen, Apoptosis, Cell culture, biology.protein
Abstract

Group I Burkitt lymphoma (BL) cell lines (L3055, Elijah, Louckes, BL2, and BL29) retaining the original biopsy phenotype were found to undergo prolonged phenotypic, functional, and molecular change on short-term exposure to soluble recombinant CD40L trimer. Sensitivity to, extent of, and duration of change appeared to reflect passage number in that the earliest passaged lines, L3055 and BL29, were generally the most susceptible. Culture of group I BL lines with CD40L resulted in significant growth arrest (without apoptosis) that, for L3055 cells, was sustained for 7 to 9 days after 72 hours of exposure. This was accompanied by the formation of large homotypic aggregates together with gross changes in individual cell morphology and a concomitant upregulation of CD54 (ICAM-1). Three of the five group I BL lines exhibited rapid downregulation of the hallmark CD77 surface antigen, which, for L3055 cells, was maintained for at least 12 days after 72 hours of incubation with CD40L. With the exception of BL2, all group I BL lines were induced to express CD40 homodimers on CD40-stimulation, whereas only monomers were detected in unstimulated cells. Experiments using CD40-transfected Rat-1 fibroblasts showed that the ability to signal for dimer formation required Thr234of CD40. For L3055 and BL29 cells, an initial 72 hours of exposure to CD40L resulted in the maintenance of homodimers for up to 14 and 10 days, respectively. There was a close correlation between the induction and duration of CD40 homodimers and the appearance of Bcl-2. For L3055 cells, which are sensitive to apoptosis-induction on BCR-engagement, exposure to CD40L for 72 hours was found to provide considerable protection from anti-IgM, which was still significant to 20 days. The implications of such sustained effects on relatively short-term exposure of tumor B cells to CD40L are discussed. © 1998 by The American Society of Hematology.

Published
1998
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102. Anti-proliferative activity and mechanism of action of titanocene dichloride

Author

L Hodgkins, David J. Kerr, David Ferry, Aristides G. Eliopoulos, Lawrence S. Young, and C. V. Christodoulou

Subjects
Cancer Research, Antineoplastic Agents, Apoptosis, Biology, DNA Adducts, chemistry.chemical_compound, In vivo, Antineoplastic Combined Chemotherapy Protocols, Organometallic Compounds, Tumor Cells, Cultured, medicine, Humans, Cytotoxicity, Ovarian Neoplasms, Titanium, Cisplatin, Cell Cycle, Titanocene dichloride, Drug Synergism, DNA, Neoplasm, Cell cycle, In vitro, Up-Regulation, Oncology, Mechanism of action, chemistry, Drug Resistance, Neoplasm, Immunology, Cancer research, Platinum Compound, Female, Fluorouracil, Drug Screening Assays, Antitumor, Tumor Suppressor Protein p53, medicine.symptom, Cell Division, Research Article, DNA Damage, medicine.drug
Abstract

Development of resistance to cytotoxic agents is a major limitation to their clinical use. Novel compounds are synthesized with a view to develop non-cross-resistant, less toxic and more potent activity. The detection of the anti-tumour properties of the inorganic compound cisplatin stimulated a broad search for other metal-containing complexes. Titanocene dichloride was synthesized on this basis and has shown potent anti-neoplastic activity in experimental animals. We have examined the in vitro activity of titanocene dichloride in two pairs of platinum-sensitive and resistant human ovarian carcinoma cell lines, A2780/2780CP and CH1/CH1cisR, and in mutated p53- and bcl-2-transfected clones of A2780 cells. A time- and concentration-dependent anti-proliferative effect was observed in all cell lines treated with titanocene dichloride. The drug was found to significantly overcome platinum resistance in the 2780CP and the CH1 cisR cell lines and in the bcl-2 and the mutant p53 transfectants of A2780 cells. Titanocene dichloride induced a block in late S/early G2 phase of the cell cycle; however apoptotic cell death occurred from any phase of cycle. Titanium-DNA adducts were detected in A2780 cells treated with titanocene dichloride using atomic absorption spectrometry, suggesting that DNA may be a target for this drug. In agreement with this finding, p53 accumulated rapidly in drug-treated A2780 cells, indicative of a role for titanocene dichloride as a DNA-damaging agent. We have also performed studies to determine whether titanocene dichloride could demonstrate synergy with other cytotoxic agents in vitro. Isobologram analysis of cytotoxicity data obtained suggests that the combination of titanocene dichloride and 5-fluorouracil (5-FU) is synergistic. The potent in vivo anti-tumour activity of this compound, supported by the encouraging results from two phase I clinical trials, suggests that titanocene dichloride could be a promising novel chemotherapeutic agent. Images Figure 4 Figure 5

Published
1998
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103. Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1)

Author

Lawrence S. Young and Aristides G. Eliopoulos

Subjects
Herpesvirus 4, Human, Cancer Research, Gene Expression, Biology, Mitogen-activated protein kinase kinase, Viral Matrix Proteins, Tumor Cells, Cultured, otorhinolaryngologic diseases, Genetics, Humans, Protein kinase A, Molecular Biology, Transcription factor, Cell Line, Transformed, Oncogene Proteins, Binding Sites, MAP kinase kinase kinase, Kinase, JNK Mitogen-Activated Protein Kinases, NF-kappa B, Epstein–Barr virus latent membrane protein 1, Cell biology, Enzyme Activation, stomatognathic diseases, IκBα, Calcium-Calmodulin-Dependent Protein Kinases, Cancer research, Mitogen-Activated Protein Kinases, Signal transduction, HeLa Cells, Signal Transduction
Abstract

Expression of the oncogenic Epstein-Barr virus (EBV)-encoded Latent Membrane Protein 1 (LMP1) activates signalling on the NF-kappaB axis through two distinct domains in the cytoplasmic C-terminus of the protein, namely CTAR1 (aa 187-231) and CTAR2 (aa 351-386). Whilst this effect is responsible for some of the functional consequences of LMP1 expression, additional LMP1-mediated signalling pathways may exist which contribute to the pleiotropic activities of this protein. In this study we provide evidence of a kinase cascade being activated by LMP1. Thus, we demonstrate that stable or transient expression of the LMP1 prototype from B95.8 in cells of epithelial or B cell origin activates the c-Jun N-terminal kinase (JNK, also known as the stress-activated protein kinase, SAPK) pathway, an effect which was found to be mediated through CTAR2 but not CTAR1. LMP1 from the Cao viral strain or LMP1 homologues from the simian EBV naturally infecting baboons and rhesus monkeys were also able to activate JNK. This phenomenon translates to induction of AP-1, a transcription factor which is readily activated by growth factors and mitogens. Interestingly, an LMP1/ CD40 chimaera comprising of the N-terminus and transmembrane domain of LMP1 and the cytoplasmic tail of CD40 which shares a common TRAF binding motif with CTAR1, effectively induced JNK. As NF-kappaB and JNK are co-activated in LMP1-expressing cells, we investigated whether the two pathways are overlapping or independent. We have found that inhibition of NF-kappaB by metabolic inhibitors or a constitutively active mutated IkappaBalpha does not impair the ability of LMP1 to signal on the JNK axis. Conversely, whilst a dominant negative mutated SEK (JNKK) inhibited LMP1-induced JNK activation, it did not affect NF-kappa-B suggesting that these two LMP1-mediated pathways are divergent.

Published
1998
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104. Flow-cytometric analysis of peripheral blood lymphocytes in patients with chronic idiopathic neutropenia of adults

Author

Aristides G. Eliopoulos, D. Sakellariou, V. Kapsimali, Helen A. Papadaki, D. Kyriakou, and George D. Eliopoulos

Subjects
Adult, Male, medicine.medical_specialty, Neutropenia, Adolescent, T-Lymphocytes, Lymphocyte, Biology, Natural killer cell, CD57 Antigens, T-Lymphocyte Subsets, Internal medicine, medicine, Humans, Lymphocyte Count, Lymphocytes, Aged, B-Lymphocytes, Leukopenia, Receptors, IgG, Hematology, General Medicine, T lymphocyte, Middle Aged, Flow Cytometry, medicine.disease, CD56 Antigen, Extravasation, Killer Cells, Natural, Phenotype, medicine.anatomical_structure, Endocrinology, Chronic Disease, Immunology, Leukocyte Common Antigens, Female, Lymphocytopenia, medicine.symptom, CD8
Abstract

Flow-cytometric analysis of peripheral blood lymphocytes was performed in 96 patients with chronic idiopathic neutropenia of adults (CINA) and in 36 age- and sex-matched healthy volunteers (controls) using a panel of monoclonal antibodies. Patients were classified arbitrarily into group A (68 patients with 2500-1500 neutrophils/microliter) and group B (28 patients with neutrophil counts below 1500/microliter). We found that CINA patients displayed low numbers of peripheral blood lymphocytes compared with the controls, which correlated with the numbers of circulating neutrophils. This decrease was due mainly to the reduction of T lymphocytes and, to lesser degree, to the decline of NK cells. Both CD4+ and CD8+ T cells decreased, so that the CD4+/CD8+ cell ratio remained within normal range. Moreover, decrease of T lymphocytes was due essentially to the diminution of CD45RO+ T-cell subsets (CD4+/CD45RO+ and CD8+/CD45RO+), while CD45RA+ T cells did not change. A highly significant positive correlation was found between the numbers of CD45RO+ T cells and the numbers of circulating neutrophils. All these alterations were more pronounced in the patients of group B than in those of group A. NK cells were found to be significantly reduced in the patients of group B, but not in those of group A. The numbers of both CD16+ and CD56+ cells correlated with the numbers of circulating neutrophils. Patients of group B had also low numbers of CD57+ cells, probably due to the reduction of T cells and NK cells. B cells did not change significantly. No significant changes were found also in the numbers of lymphocytes carrying activation-related cell surface markers. We concluded that lymphocyte reduction in CINA patients is due mainly to the diminution of CD45RO+ cells, and we postulated that the most probable explanation for this abnormality is an increased extravasation of these cells, which pass into the tissues following an accelerated adhesion to endothelial cells. This hypothesis and its relationship with the underlying neutropenia in CINA patients remain to be clarified.

Published
1997
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105. Epstein – Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-κB pathway involving TNF receptor-associated factors

Author

Liz Hodgkin, Maria Stack, Christopher W. Dawson, Aristides G. Eliopoulos, Lawrence S. Young, Kenneth M. Kaye, Sim K. Sihota, and Martin Rowe

Subjects
TRAF3, Herpesvirus 4, Human, Cancer Research, TRAF2, medicine.medical_treatment, Molecular Sequence Data, Transfection, Epithelium, Receptors, Tumor Necrosis Factor, Viral Matrix Proteins, Tumor Cells, Cultured, otorhinolaryngologic diseases, Genetics, medicine, Humans, Amino Acid Sequence, CD40 Antigens, Molecular Biology, Transcription factor, Ovarian Neoplasms, Binding Sites, CD40, TNF Receptor-Associated Factor 3, biology, Interleukin-6, NF-kappa B, Proteins, Cell Transformation, Viral, TNF Receptor-Associated Factor 2, TNF Receptor-Associated Factor 1, Protein Structure, Tertiary, Cell biology, stomatognathic diseases, Cytokine, Urinary Bladder Neoplasms, biology.protein, Cancer research, Female, Signal transduction, Cell Division, HeLa Cells
Abstract

Expression of the Epstein-Barr virus (EBV) transforming LMP1 in B cells activates the transcription factor NF-kappaB and induces phenotypic changes through two distinct domains in the cytoplasmic C-terminus of the protein. The aa 187-231 domain of LMP1, which is important for growth transformation, binds tumour necrosis factor (TNF) receptor associated factor (TRAF) 1 and TRAF3 and this interaction mediates subsequent signalling events. The TRAFs also associate with CD40, a member of the TNFR family, which upon ligation activates NF-kappaB and induces phenotypic changes similar to those mediated by LMP1. This study demonstrates that LMP1 expression in carcinoma cell lines and SV40-transformed keratinocytes results in induction of the pleiotropic cytokine interleukin 6 (IL6), an effect which is also observed upon CD40 ligation. The mechanism by which either LMP1 expression or CD40 ligation induces IL6 production was found to be NF-kappaB-dependent. Mutational analysis identified domains in the C-terminus of LMP1 which are important for NF-kappaB activation and IL6 secretion. LMP1 and CD40 share a common PxQxT core TRAF binding motif and mutations in or adjacent to this sequence impaired the ability of LMP1 or CD40 to induce NF-kappaB activation and IL6 secretion. The importance of TRAF interactions in mediating these effects was confirmed using dominant negative TRAF2 and TRAF3 mutants which also identified differences in the signalling events mediated by the two NF-kappaB activating domains of LMP1. A20, an anti-apoptotic protein which interacts with TRAF2 and blocks CD40-mediated NF-kappaB activity, also blocked NF-kappaB and IL6 secretion in LMP1-transfected epithelial cells. These results suggest that LMP1 regulates IL6 production in epithelial cells in a manner similar to CD40 ligation and implicate TRAFs as common mediators in the transduction of signals generated via the CD40 and LMP1 pathways. As a role for IL6 in regulating epithelial cell growth has previously been suggested, the control of IL6 secretion via the CD40 and LMP1 pathways may have implications for the growth of both normal and transformed epithelial cells.

Published
1997
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106. Viruses and apoptosis

Author

Lawrence S. Young, Christopher W. Dawson, and Aristides G. Eliopoulos

Subjects
viruses, Cellular pathways, Apoptosis, HIV Infections, General Medicine, Biology, Virus diseases, medicine.disease_cause, Virology, Receptors, Tumor Necrosis Factor, Virus, Genes, bcl-2, Viral Proteins, Apoptotic Process, Virus Diseases, Infectious disease (medical specialty), medicine, Cancer research, Adenovirus E1 Proteins, Humans, Viral disease, Carcinogenesis, Virus Physiological Phenomena
Abstract

Virus infection and replication are often associated with apoptosis and this effect is likely to be responsible for much of the pathology associated with infectious disease. Many viruses encode proteins which can inhibit apoptosis thereby either prolonging the survival of infected cells such that the production of progeny virus is maximised or facilitating the establishment of virus persistence. These viral proteins target the cellular pathways responsible for regulating apoptosis and have been instrumental in furthering our understanding of the apoptotic process. Many of the viruses associated with oncogenic transformation have adopted strategies for blocking apoptosis highlighting the centrality of this effect in carcinogenesis. Understanding the mechanisms by which viruses regulate apoptosis may lead to the development of novel therapies for both infectious disease and cancer.

Published
1997
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107. TPL2 kinase is a suppressor of lung carcinogenesis

Author

Philip N. Tsichlis, Kalliopi Gkouskou, Aristides G. Eliopoulos, Kostantinos Evangelou, Dimitra Vyrla, John K. Field, Triantafillos Liloglou, Vasiliki Pelekanou, Dimitris C. Kanellis, Georgios Nikolaidis, Urszula Oleksiewicz, Efstathios N. Stathopoulos, Michalis Liontos, Vassilis G. Gorgoulis, and Katerina Gkirtzimanaki

Subjects
Lung Neoplasms, DNA Mutational Analysis, Immunoblotting, Molecular Sequence Data, Biology, medicine.disease_cause, Bioinformatics, Polymerase Chain Reaction, 03 medical and health sciences, Mice, 0302 clinical medicine, Proto-Oncogene Proteins, microRNA, medicine, Animals, Humans, Epigenetics, Lung cancer, 030304 developmental biology, DNA Primers, Regulation of gene expression, 0303 health sciences, Multidisciplinary, MAP kinase kinase kinase, Base Sequence, Kinase, Sequence Analysis, DNA, DNA Methylation, medicine.disease, Flow Cytometry, MAP Kinase Kinase Kinases, 3. Good health, Gene Expression Regulation, Neoplastic, MicroRNAs, Cell Transformation, Neoplastic, PNAS Plus, 030220 oncology & carcinogenesis, DNA methylation, ras Proteins, Carcinogenesis
Abstract

Lung cancer is a heterogeneous disease at both clinical and molecular levels, posing conceptual and practical bottlenecks in defining key pathways affecting its initiation and progression. Molecules with a central role in lung carcinogenesis are likely to be targeted by multiple deregulated pathways and may have prognostic, predictive, and/or therapeutic value. Here, we report that Tumor Progression Locus 2 (TPL2), a kinase implicated in the regulation of innate and adaptive immune responses, fulfils a role as a suppressor of lung carcinogenesis and is subject to diverse genetic and epigenetic aberrations in lung cancer patients. We show that allelic imbalance at the TPL2 locus, up-regulation of microRNA-370, which targets TPL2 transcripts, and activated RAS (rat sarcoma) signaling may result in down-regulation of TPL2 expression. Low TPL2 levels correlate with reduced lung cancer patient survival and accelerated onset and multiplicity of urethane-induced lung tumors in mice. Mechanistically, TPL2 was found to antagonize oncogene-induced cell transformation and survival through a pathway involving p53 downstream of cJun N-terminal kinase (JNK) and be required for optimal p53 response to genotoxic stress. These results identify multiple oncogenic pathways leading to TPL2 deregulation and highlight its major tumor-suppressing function in the lung.

Published
2013

108. Enhanced therapeutic anti-tumor immunity induced by co-administration of 5-fluorouracil and adenovirus expressing CD40 ligand

Author

Dimitra Vyrla, Katerina Gkirtzimanaki, Angelica Loskog, Lina Liljenfeldt, Emma Svensson, and Aristides G. Eliopoulos

Subjects
Male, Cancer Research, Antimetabolites, Antineoplastic, Fas Ligand Protein, T cell, medicine.medical_treatment, Genetic enhancement, T-Lymphocytes, Immunology, CD40 Ligand, Mice, Nude, chemical and pharmacologic phenomena, Apoptosis, Cell Growth Processes, Pharmacology, Lymphocyte Activation, Adenoviridae, Mice, Immune system, Cell Line, Tumor, medicine, Immunology and Allergy, Cytotoxic T cell, Animals, Humans, fas Receptor, CD154, CD40, biology, business.industry, Immunology in the medical area, Immunotherapy, Combined Modality Therapy, Recombinant Proteins, 3. Good health, Mice, Inbred C57BL, medicine.anatomical_structure, Oncology, Urinary Bladder Neoplasms, Immunologi inom det medicinska området, Antibody Formation, biology.protein, Immunogenic cell death, Female, Fluorouracil, business
Abstract

Bystander immune activation by chemotherapy has recently gained extensive interest and provided support for the clinical use of chemotherapeutic agents in combination with immune enhancers. The CD40 ligand (CD40L; CD154) is a potent regulator of the anti-tumor immune response and recombinant adenovirus (RAd)-mediated CD40L gene therapy has been effective in various cancer models and in man. In this study we have assessed the combined effect of local RAd-CD40L and 5-fluorouracil (5-FU) administration on a syngeneic MB49 mouse bladder tumor model. Whereas MB49 cells implanted into immunocompetent mice responded poorly to RAd-CD40L or 5-FU alone, administration of both agents dramatically decreased tumor growth, increased survival of the mice and induced systemic MB49-specific immunity. This combination treatment was ineffective in athymic nude mice, highlighting an important role for T cell mediated anti-tumor immunity for full efficacy. 5-FU up-regulated the expression of Fas and immunogenic cell death markers in MB49 cells and cytotoxic T lymphocytes from mice receiving RAd-CD40L immunotherapy efficiently lysed 5-FU treated MB49 cells in a Fas ligand-dependent manner. Furthermore, local RAd-CD40L and 5-FU administration induced a shift of myeloid-derived suppressor cell phenotype into a less suppressive population. Collectively, these data suggest that RAd-CD40L gene therapy is a promising adjuvant treatment to 5-FU for the management of bladder cancer.

Published
2013

109. TNF receptors and their ligands: in sickness and in health, in life and death

Author

Aristides G. Eliopoulos and Lawrence S. Young

Subjects
Pharmacology, business.industry, Drug Discovery, Immunology, Medicine, Cancer, Tumor necrosis factor alpha, business, medicine.disease, Receptor, Virus
Abstract

Lawrence Young is currently Directorof the Cancer Research UK Institutefor Cancer Studies and Head ofDivision of Cancer Studies at theUniversity of Birmingham MedicalSchool. His research interests focuson the role of virus infection in thepathogenesis of cancer, on tumourimmunology and on the developmentof novel anti-cancer therapies.Aristides G Eliopoulos

Published
2004
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110. SUMOylation is required for optimal TRAF3 signaling capacity

Author

Aristides G. Eliopoulos, Kalliopi Gkouskou, Sophia Miliara, and Tyson V. Sharp

Subjects
TRAF3, Lymphoma, SUMO protein, lcsh:Medicine, Ubiquitin-conjugating enzyme, Biology, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, NF-kappa B p52 Subunit, Two-Hybrid System Techniques, Protein Interaction Mapping, Humans, Protein Interaction Domains and Motifs, CD40 Antigens, lcsh:Science, Transcription factor, 030304 developmental biology, 0303 health sciences, Multidisciplinary, TNF Receptor-Associated Factor 3, lcsh:R, Signal transducing adaptor protein, Sumoylation, Molecular biology, 3. Good health, Cell biology, Cell Transformation, Neoplastic, 030220 oncology & carcinogenesis, Proteolysis, Ubiquitin-Conjugating Enzymes, biology.protein, lcsh:Q, Signal transduction, Research Article, Protein Binding, Signal Transduction
Abstract

TNF receptor–associated factors (TRAFs) are multifunctional adaptor proteins involved in temporal and spatial coordination of signals necessary for normal immune function. Here, we report that TRAF3, a TRAF family member with a key role in Toll-like and TNF family receptor signaling and suppressor of lymphomagenesis, is post-translationally modified by the small ubiquitin-related modifier (SUMO). Through yeast two-hybrid and co-immunoprecipitation assays we have identified Ubc9, the SUMO conjugating enzyme, as a novel TRAF3-interacting protein. We show that Ubc9-dependent SUMOylation of TRAF3 modulates optimal association with the CD40 receptor, thereby influencing TRAF3 degradation and non-canonical NF-κB activation upon CD40 triggering. Collectively, our findings describe a novel post-translational modification of a TRAF family member and reveal a link between SUMOylation and TRAF-mediated signal transduction.

Published
2013

111. Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apc min mice by inhibiting IL-10 secretion and regulatory T-cell generation

Author

Changchuin Mao, Oksana B. Serebrennikova, Khashayarsha Khazaie, Philip N. Tsichlis, Aristides G. Eliopoulos, Elias Gounaris, Wenying Ren, Linda D. Siracusa, and Christos Tsatsanis

Subjects
Adenoma, Male, medicine.medical_specialty, Genes, APC, Regulatory T cell, Intestinal polyp, Gene Expression, Inflammation, Tumor initiation, T-Lymphocytes, Regulatory, Mice, 03 medical and health sciences, 0302 clinical medicine, Intestinal mucosa, Proto-Oncogene Proteins, Internal medicine, Intestinal Neoplasms, medicine, Animals, Intestinal Mucosa, STAT3, PI3K/AKT/mTOR pathway, Bone Marrow Transplantation, 030304 developmental biology, Mice, Knockout, 0303 health sciences, Multidisciplinary, biology, Models, Immunological, Inflammatory Bowel Diseases, MAP Kinase Kinase Kinases, Mice, Mutant Strains, Interleukin-10, Mice, Inbred C57BL, Interleukin 10, medicine.anatomical_structure, Endocrinology, PNAS Plus, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Female, medicine.symptom
Abstract

To address the role of Tpl2, a MAP3K8 that regulates innate/adaptive immunity and inflammation, in intestinal tumorigenesis, we crossed a Tpl2 KO allele into the Apc min/+ genetic background. Here, we show that Apc min/+ /Tpl2 −/− mice exhibit a fivefold increase in the number of intestinal adenomas. Bone marrow transplantation experiments revealed that the enhancement of polyposis was partially hematopoietic cell-driven. Consistent with this observation, Tpl2 ablation promoted intestinal inflammation. IL-10 levels and regulatory T-cell numbers were lower in the intestines of Tpl2 −/− mice, independent of Apc and polyp status, suggesting that they were responsible for the initiation of the enhancement of tumorigenesis caused by the ablation of Tpl2 . The low IL-10 levels correlated with defects in mTOR activation and Stat3 phosphorylation in Toll-like receptor-stimulated macrophages and with a defect in inducible regulatory T-cell generation and function. Both polyp numbers and inflammation increased progressively with time. The rate of increase of both, however, was more rapid in Apc min/+ /Tpl2 −/− mice, suggesting that the positive feedback initiated by inflammatory signals originating in developing polyps is more robust in these mice. This may be because these mice have a higher intestinal polyp burden as a result of the enhancement of tumor initiation.

Published
2012
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112. TRPP1

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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113. Tumor Rejection Antigen gp96

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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114. TCP-1 and Cct1

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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115. TRAM-1

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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116. Type II PIP Kinase

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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117. TMEM85 (Transmembrane Protein 85)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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118. T10 Antigen

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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119. TRIF-Related Adapter Molecule

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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120. The Cholecystokinin-B Receptor

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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121. TRIP13/16E1BP/Thyroid Hormone Receptor Interactor 13 (AGS7)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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122. TLR4, Toll-Like Receptor 4

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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123. TRAIL Receptor 1/2 (Death Receptor 4/5, DR4/5)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

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2012
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124. Tef-3

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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125. Toll-Like Receptor 9

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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126. Translocation-Associated Notch Homolog

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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127. Toll-like receptor 5

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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128. Type-I Cadherins

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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129. TEA Domain Family Member 4

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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130. tm-PTPe

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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131. Toll/Interleukin-1 Receptor Domain-Containing Protein

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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132. Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

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2012
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133. TIR-Domain-Containing Adapter Molecule 1

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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134. TRP (Transient Receptor Potential Cation Channel)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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135. TFE3/Transcription Factor Binding to IGHM Enhancer 3 (AGS11)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

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2012
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136. TEF-5

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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137. TSPAN 28

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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138. Toll-Like Receptor Adaptor Protein 3

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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139. TIR-Domain-Containing Adapter Molecule 2

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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140. The Leukocyte Common Antigen (LCA)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

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2012
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141. Type II PIPK

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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142. Toll-like Receptor Adaptor Protein Family Members

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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143. TEAD-4

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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144. Testosterone/Dihydrotestosterone Receptor

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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145. TEC1 (S. cerevisiae)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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146. TEA Domain Family Member 1

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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147. TIR-Domain-Containing Adapter Protein Inducing IFN-Beta

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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148. Toll-Like Receptor 4

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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149. Type IV cAMP Phosphodiesterase

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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150. TIF6 (eIF6)

Author

João Gonçalves, Helena Soares, Norman L. Eberhardt, Sarah C. R. Lummis, David R. Soto-Pantoja, David D. Roberts, Umadas Maitra, Romit Majumdar, Arunima Biswas, Avik Choudhuri, Jayalakshmi Krishnan, Sangdun Choi, Shaikh M. Atif, Stephen J. McSorley, Michael T. Greenwood, Aisha Qasim Butt, Sinéad M. Miggin, Felipe Francisco Tuon, Enda Shevlin, Austin Della-Franca, Yuyan Chen, Jennifer Anne Byrne, Dimitra Virla, Christos Tsatsanis, Aristides G. Eliopoulos, Maréne Landström, Reshma Sundar, Eun-Sil Sung, Yong-Sung Kim, Adrienn Angyal, Endre Kiss-Toth, and Christian Harteneck

Published
2012
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