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This article considers an archive of letters written by three generations of female kin as offering a form for thinking about the nature of kin relations. It tells the story of how the archive came...

Objective: This study examined the impact of early biofilm on the tooth surface, during the assessment of initial enamel erosion using swept-source optical coherence tomography (SS-OCT). Method and materials: Forty-five enamel windows of 2 × 4 mm2 were prepared on 23 extracted human teeth. The specimens were exposed to citric acid (pH 3.2) for 30 minutes and randomly divided into three groups (n = 15): Group 1, no biofilm; Group 2, 1-day-old biofilm; and Group 3, 3-day-old biofilm. Specimens in Groups 2 and 3 were inoculated with oral bacteria (Streptococcus sanguinis, Streptococcus mitis, and Actinomyces naeslundii) to produce early laboratory-cultivated biofilms for 1 and 3 days respectively. Surface microhardness (SMH) measurements were taken at pre- (t1) and post-erosion (t2); and SS-OCT scans were done at t1, t2, and post-biofilm cultivation (t3). Integrated reflectivity (IR) of the tooth-air interface (IRsurface) and enamel (IRenamel) were computed from the mean A-scans. Statistical analysis was performed using paired t tests and one-way ANOVA (α = .05). Results: A significant increase in IRenamel was observed at t2 (P .05). At t3, IRsurface between Group 1 (control) and Group 2 (P = .012) as well as Group 3 (P = .001) were significantly different. Significant variances in IRenamel were perceived between t2 and t3 for Groups 2 and 3 but not for Group 1. Conclusion: As early biofilm affected SS-OCT assessment of initial enamel erosion, they should be removed from the tooth surface prior to OCT procedures..

Salmonella spp. is a leading cause of gastrointestinal enteritis in humans where it is largely contracted via contaminated poultry and pork. Phages can be used to control Salmonella infection in the animals, which could break the cycle of infection before the products are accessible for consumption. Here, the potential of 21 myoviruses and a siphovirus to eliminate Salmonella in vitro and in vivo was examined with the aim of developing a biocontrol strategy to curtail the infection in poultry and swine. Together, the phages targeted the twenty-three poultry and ten swine prevalent Salmonella serotype isolates tested. Although individual phages significantly reduced bacterial growth of representative isolates within 6 h post-infection, bacterial regrowth occurred 1 h later, indicating proliferation of resistant strains. To curtail bacteriophage resistance, a novel three-phage cocktail was developed in vitro, and further investigated in an optimized Galleria mellonella larva Salmonella infection model colonized with representative swine, chicken and laboratory strains. For all the strains examined, G. mellonella larvae given phages 2 h prior to bacterial exposure (prophylactic regimen) survived and Salmonella was undetectable 24 h post-phage treatment and throughout the experimental time (72 h). Administering phages with bacteria (co-infection), or 2 h post-bacterial exposure (remedial regimen) also improved survival (73–100% and 15–88%, respectively), but was less effective than prophylaxis application. These pre-livestock data support the future application of this cocktail for further development to effectively treat Salmonella infection in poultry and pigs. Future work will focus on cocktail formulation to ensure stability and incorporation into feeds and used to treat the infection in target animals.

International audience; Design, development, manufacturing, and test activities of the RF power system (RFPS) for Linear IFMIF Prototype Accelerator (LIPAc) were completed in Europe. Installation and commissioning activities were carried out at the International Fusion Materials Irradiation Facility-Engineering Validation and Engineering Design Activities (IFMIF/EVEDA) site in Rokkasho, Japan. Challenging IFMIF requirements led to a number of innovations during design and development. Commissioning required a major effort on calibration and fine setting and led to development of new functionalities. The RFPS was validated under full power and 125-mA deuteron beam loading conditions, in the radio frequency quadrupole (RFQ), demonstrating good performance. This article is an overview about how technical challenges impacted the prototype RFPS design and its functional evolution during commissioning, cavity conditioning, and beam operation of the RFQ.

Summary Background In the context of the COVID-19 pandemic, prone position (PP) has been frequently used in the intensive care units to improve the prognosis in patients with respiratory distress. However, turning patients to prone imply important complications such as pressure ulcers. The aim of this paper is to describe the prevalence and characteristics of prone-positioning pressure sores (PPPS) and analyze the related risk factors. Methods A case-control study was performed in Gregorio Maranon hospital in Madrid during the COVID-19 pandemic between April and May 2020. We enrolled 74 confirmed COVID-19 patients in critical care units with invasive mechanical ventilation who were treated with pronation therapy. There were 57 cases and 17 controls. Demographic data, pronation maneuver characteristics and PPPS features were analyzed. Results In the case group, a total number of 136 PPPS were recorded. The face was the most affected region (69%). Regarding the severity, stage II was the most frequent. The main variables associated with an increased risk of PPPS were the total number of days under pronation cycles, and PP maintained for more than 24 h. The prealbumin level at admission was significantly lower in the case group. All of the ulcers were treated with dressings. The most frequent acute complication was bleeding (5%). Conclusions According to our study, PPPS are related to the characteristics of the maneuver and the previous nutritional state. The implementation of improved positioning protocols may enhance results in critical patient caring, to avoid the scars and social stigma that these injuries entail.

Dental caries is one of the most common dental problems that is usually managed with the removal of carious tooth structure and replace with biocompatible dental materials. Currently, polymer composites are widely utilized as dental restoration materials due to their astonishing properties such as good tribological, thermal, mechanical, physical, and excellent aesthetic appearance. Various modifications have been made to improve the performance of these dental composites, which have been the subject of investigation by many researchers. This chapter encompasses the different types of matrix, fillers, additives in resin-based composite. It also elaborates on the polymerization process and kinetics, types of photoinitiators, and post-polymerization reaction. Additionally, the different application methods which are incremental and bulk fill techniques are discussed in greater details. This chapter also highlights the different types of light curing units and their influence on the curing of the composite.

The mechanism of gender disparity in cutaneous melanoma incidence remains unclear. Steroid hormones including estrogens have long been implicated in the course of melanoma, but the conclusion is controversial. Estrogen receptors (ERs) and insulin-like growth factor 1 receptor (IGF1R) show extensive crosstalk in cancer development, but how the ER/IGF1R network impacts melanoma is currently unclear. Here we studied the melanoma associations of selected SNPs from the ER/IGF1R network. Part of the International Genes, Environment, and Melanoma (GEM) cohort was used as a discovery set, and the Gene Environment Association Studies Initiative (GENEVA) dataset served as a validation set. Based on the associations with other malignant disease conditions, thirteen single nucleotide polymorphism (SNP) variants in ESR1, ESR2, IGF1, and IGF1R were selected for candidate gene association analyses. The rs1520220 in IGF1 and rs2229765 in IGF1R variants were significantly associated with melanoma risk in the GEM dataset after Benjamini-Hochberg multiple comparison correction, although they were not validated in the GENEVA set. The discrepancy may be caused by the multiple melanoma characteristics in the GEM patients. Further analysis of gender disparity was carried out for IGF1 and IGF1R SNPs in the GEM dataset. The GG phenotype in IGF1 rs1520220 (recessive model) presented an increased risk of melanoma (OR = 8.11, 95% CI: 2.20, 52.5, p = 0.006) in men but a significant opposite effect in women (OR = 0.15, 95% CI: 0.018, 0.86, p = 0.045). The AA genotype in IGF1R rs2229765 (recessive model) showed a significant protective effect in men (OR = 0.24, 95% CI: 0.07, 0.64, p = 0.008) and no effect in women. Results from the current study are warranted for further validation.

Background Hospitalisation during the last weeks of life when there is no medical need or desire to be there is distressing and expensive. This study sought palliative care initiatives which may avoid or shorten hospital stay at the end of life and analysed their success in terms reducing bed days. Methods Part 1 included a search of literature in PubMed and Google Scholar between 2013 and 2018, an examination of governmental and organisational publications plus discussions with external and co-author experts regarding other sources. This initial sweep sought to identify and categorise relevant palliative care initiatives. In Part 2, we looked for publications providing data on hospital admissions and bed days for each category. Results A total of 1252 abstracts were reviewed, resulting in ten broad classes being identified. Further screening revealed 50 relevant publications describing a range of multi-component initiatives. Studies were generally small and retrospective. Most researchers claim their service delivered benefits. In descending frequency, benefits identified were support in the community, integrated care, out-of-hours telephone advice, care home education and telemedicine. Nurses and hospices were central to many initiatives. Barriers and factors underpinning success were rarely addressed. Conclusions A wide range of initiatives have been introduced to improve end-of-life experiences. Formal evidence supporting their effectiveness in reducing inappropriate/non-beneficial hospital bed days was generally limited or absent. Trial registration N/A

During the last years CIEMAT has been leading the activities in the European Program to develop an integral breeding blanket with advanced performances to work in a realistic DEMO scenario. This blanket is the Dual Coolant Lithium Lead (DCLL) working at a limited temperature in order to allow the use of conventional materials and technologies. The design of this blanket was finished, including the definition of the tritium extraction system and tritium simulations. Then, determined by the selection of other two concepts as driver blankets for DEMO, the focus was put on developing a novel BB still based on the DCLL concept but working at higher temperatures, thus increasing the plant net efficiency. In this work, a summary of the status of the DCLL is presented, together with some ideas for developing an advanced high temperature DCLL in the near future.

In the last years, CIEMAT worked in the development of a low temperature DCLL breeding blanket design aimed at using conventional materials and technologies. It followed the multi-module segment (MMS) approach, which allows operating within the thermal range tolerated by EUROFER while keeping a low bulk velocity of the self-cooled liquid breeder (PbLi) in the breeding zone. Thinking in the commercial exploitation of fusion, it must be taken into account that there is risk that the foreseen availability goal in fusion reactors is not achieved. In that case, the limited net efficiency of low temperature blankets could not be sufficient to obtain a competitive cost of the electricity. For that reason, more advanced blanket solutions are being explored with the objective of developing a simpler, more reliable and more efficient design based on a single-module segment (SMS) architecture and the use of self-cooled incompressible liquid breeder. In this work, different strategies to solve interrelated aspects like the topology and electrical insulation of the breeder circuits, the first wall integration and the main neutronic responses are analysed and discussed.

The Linear IFMIF (International Fusion Materials Irradiation Facility) Prototype Accelerator (LIPAc) is a 9 MeV, 125 mA, continuous wave (CW) deuteron accelerator aimed to validate the technology for the IFMIF accelerators. The construction of LIPAc, which is currently the most powerful deuteron accelerator in the world, has been carried out under the Broader Approach (BA) Agreement between EU and Japan, and it is located at Rokkasho (Japan). CIEMAT is one of the five European Institutions that has participated in the design, manufacturing and commissioning/operation of the main accelerator components, among them, the Radio Frequency Power System (RFPS). The RFPS contains all the equipment necessary to generate the required RF power to feed the LIPAc cavities. These cavities demand eighteen RF power chains at 175 MHz being distributed as follows: eight 200 kW tetrode-based chains for the Radiofrequency Quadrupole (RFQ), two 16 kW solid-state chains for the re-buncher cavities, and eight 105 kW tetrode-based chains for the Superconducting RF Linac Half-Wave Resonators. The design of the RFPS main components is presented in this paper, including the tetrode-based chains, the Solid-State Power Amplifier (SSPA) for the re-buncher cavities, the High Voltage Power Supplies (HVPSs) for the final amplifiers anodes and the RF water cooling system. Additionally, the main difficulties encountered during the first months of the RFPS commissioning and operation will be described, together with the applied improvements.

Based on ethnographic research and critical reflection on Carlos Reygadas’s film Post Tenebras Lux, this article explores the texture and temporality of crisis and endurance in Mexico. Specifically, it traces the transformation of one of Mexico City’s ubiquitous anexos (annexes), which names coercive drug treatment centers run by and for the informal working poor. In putting the ethnography of an anexo in dialogue with Reygadas’s film, this article develops a picture of precarious sociality in contemporary Mexico, one shaped by neoliberal reform and drug-related violence. Finally, it contemplates how the film and the anexo’s resonant “difficulty” upset sense and meaning, thereby suggesting new ways of attending to life within broader durations of politics and history.

This article is an ethnographic account of an archive of prison letters written by three generations of female kin. Based on long-term ethnographic research in rural New Mexico, it describes the context in which the letters were written, as well as the desires, preoccupations, and practices that transformed them into an archive. I have placed a particular focus on how dislocation and connection manifest in the letters and shape the kinds of narratives the archive tells. Themes of isolation, loss, and memory are explored within the wider context of colonial history and the acceleration of the carceral state. This article seeks to integrate these registers analytically, while elucidating the role of archiving for a subject’s present life.

Neurotensin (Nts) is a neuropeptide implicated in the regulation of many facets of physiology, including cardiovascular tone, pain processing, ingestive behaviors, locomotor drive, sleep, addiction and social behaviors. Yet, there is incomplete understanding about how the various populations of Nts neurons distributed throughout the brain mediate such physiology. This knowledge gap largely stemmed from the inability to simultaneously identify Nts cell bodies and manipulate them in vivo. One means of overcoming this obstacle is to study Nts(Cre) mice crossed onto a Cre-inducible green fluorescent reporter line (Nts(Cre);GFP mice), as these mice permit both visualization and in vivo modulation of specific populations of Nts neurons (using Cre-inducible viral and genetic tools) to reveal their function. Here we provide a comprehensive characterization of the distribution and relative densities of the Nts-GFP populations observed throughout the male Nts(Cre);GFP mouse brain, which will pave the way for future work to define their physiologic roles. We also compared the distribution of Nts-GFP neurons with Nts-In situ Hybridization (Nts-ISH) data from the adult mouse brain. By comparing these data sets we can distinguish Nts-GFP populations that may only transiently express Nts during development but not in the mature brain, and hence which populations may not be amenable to Cre-mediated manipulation in adult Nts(Cre);GFP mice. This atlas of Nts-GFP neurons will facilitate future studies using the Nts(Cre);GFP line to describe the physiological functions of individual Nts populations and how modulating them may be useful to treat disease.

Study objective The objective of the InMEDIATE study was to evaluate the change in intensity of traumatic pain over the first 20 min in adult patients treated with methoxyflurane versus standard analgesic treatment in Spain. This the first randomized, active-controlled, multicenter trial of methoxyflurane in the emergency setting in Europe. Methods This was a randomized, controlled study that enrolled adult patients with acute moderate to severe (score ≥4 on the 11-point Numeric Rating Scale) trauma-associated pain in 14 Spanish emergency departments. Patients were randomized 1:1 to methoxyflurane (up to 2×3 mL) or standard analgesic treatment. Coprimary endpoints were the change from baseline in Numeric Rating Scale pain intensity score during the first 20 minutes of treatment and time to first pain relief. Results Three hundred five patients were randomized (methoxyflurane 156; standard analgesic treatment 149). Most patients in the standard analgesic treatment group (70%) received intravenous first-step analgesics and 9.4% of patients were treated with opioids. Mean decrease from baseline in Numeric Rating Scale pain intensity score was greater for methoxyflurane than standard analgesic treatment at all points, with a significant treatment difference overall up to 20 minutes (repeated-measures model 2.47 versus 1.39; treatment difference 1.00; 95% confidence interval 0.84 to 1.32). Median time to first pain relief was significantly shorter for methoxyflurane than standard analgesic treatment (3 versus 10 minutes). Methoxyflurane achieved better patient and clinician ratings for pain control and comfort of treatment than standard analgesic treatment and exceeded patient and clinician expectations of treatment in, respectively, 77% and 72% of cases compared with 38% and 19% for standard analgesic treatment. Conclusion These results support consideration of methoxyflurane as a nonnarcotic, easy-to-administer, rapid-acting, first-line alternative to currently available analgesic treatments for trauma pain.

Background Pleural fluid homocysteine (HCY) can be useful for diagnosis of malignant pleural effusion (MPE). There are no published studies comparing the diagnostic accuracy of HCY with other tumour markers in pleural fluid for diagnosis of MPE. The aim was to compare the accuracy of HCY with that of carcinoembryonic antigen (CEA), cancer antigen (CA) 15.3, CA19.9 and CA125 in pleural fluid and to develop a probabilistic model using these biomarkers to differentiate benign (BPE) from MPE. Methods Patients with pleural effusion were randomly included. HCY, CEA, CA15.3, CEA19.9 and CA125 were quantified in pleural fluid. Patients were classified into two groups: MPE or BPE. By applying logistic regression analysis, a multivariate probabilistic model was developed using pleural fluid biomarkers. The diagnostic accuracy was determined by receiver operating characteristic (ROC) curves and calculating the area under the curve (AUC). Results Population of study comprised 133 patients (72 males and 61 females) aged between 1 and 96 years (median = 70 years), 81 BPE and 52 MPE. The logistic regression analysis included HCY (p< 0.0001) and CEA (p = 0.0022) in the probabilistic model and excluded the other tumour markers. The probabilistic model was: HCY+CEA = Probability(%) = 100x( 1 +e(-z))(-1), where Z = 0.5471x[ HCY]+0.3846x[ CEA]-8.2671. The AUCs were 0.606, 0.703, 0.778, 0.800, 0.846 and 0.948 for CA125, CA19.9, CEA, CA15.3, HCY and HCY+CEA, respectively. Conclusions Pleural fluid HCY has higher accuracy for diagnosis of MPE than CEA, CA15.3, CA19.9 and CA125. The combination of HCY and CEA concentrations in pleural fluid significantly improves the diagnostic accuracy of the test.

The test facility (TF) is one of the three major facilities of the International Fusion Material Irradiation Facility (IFMIF). Engineering designs of TF main systems and key components have been initiated and developed in the IFMIF EVEDA (Engineering Validation and Engineering Design Activities) phase since 2007. The related work covers the designs of a test cell which is the meeting point of the TF and accelerator facility and lithium facility, a series of test modules for experiments under different irradiation conditions, an access cell to accommodate remote handling systems, four test module handling cells for test module processing and assembling, and test facility ancillary systems for engineering support on energy, media, and control infrastructure. This paper summarizes the principle functions, brief specifications, and the current design status of the above mentioned IFMIF TF systems and key components. (C) 2015 Karlsruhe Institute of Technology. Published by Elsevier B.V. All rights reserved.

Author(s): Laquer, Vivian; Dellinger, Ryan W; Mannering, Irene; Garcia, Angela Gomez; Abraham, Vivek; Pavlis, Janelle; Liu-Smith, Feng; De Feraudy, Sebastien; Meyskens, Frank L; Kelly, Kristen M

A novel procedure for the simulation of solar water disinfection (SODIS) processes in flow reactors is presented. The modeling approach includes the rigorous description of hydrodynamics, radiation transfer, mass transport and bacterial inactivation phenomena within the reactor by means of a computational fluid dynamics (CFD) software. The methodology has been evaluated in a tubular reactor coupled with a compound parabolic collector (CPC). Velocity profiles have been validated versus theoretical fully developed flow, and radiation fields versus both ray tracing and experimental actinometrical measurements. Incorporation of the solar vector calculation significantly improves the model capabilities for prediction of the potential performance of the SODIS process at different geographical coordinates and operation time. A mechanistic kinetic model was used for the description of the bacterial inactivation rate with explicit radiation absorption effects, coupling the radiation field with the mass balances of viable bacterial species. Model predictions successfully reproduce the experimental data of E. coli inactivation under different irradiances of both simulated and natural solar light with a normalized root mean squared logarithmic error (NRMSLE) of 6.65% and 9.72%, respectively. Therefore, this novel methodology is confirmed as a useful tool for the scaling-up of the SODIS process to large volume systems to be installed in remote communities where safe drinking water is not available.

SummaryA previously unknown Spanish-language mutual aid resource for substance use and mental health concerns is available in Latino communities across the USA and much of Latin America. This kind of ‘4th and 5th step’ group is a ‘culturally adapted’ version of the 12-step programme and provides empirical grounds on which to re-theorise the importance of spirituality and culture in mutual aid recovery groups. This article presents ethnographic data on this organisation.

Over the last decade, there has been a sharp increase in drug addiction in Mexico, especially among the urban poor. During the same period, unregulated residential treatment centers for addiction, known as anexos, have proliferated throughout the country. These centers are utilized and run by marginalized populations and are widely known to engage in physical violence. Based on long-term ethnographic research in Mexico City, this article describes why anexos emerged, how they work, and what their prevalence and practices reveal about the nature of recovery in a context where poverty, drugs, and violence are existential realities. Drawing attention to the dynamic relationship between violence and recovery, pain, and healing, it complicates categories of violence and care that are presumed to have exclusive meaning, illuminating the divergent meanings of, and opportunities for, recovery, and how these are socially configured and sustained.

This article reports results from a preliminary ethnographic study of a new and largely unknown self-help organization for Latinos with substance use disorders, known as “4th and 5th Step Group” (in Spanish, Grupo de Cuarto y Quinto Paso, “CQ”). It describes the nature of CQ, aspects of group membership, and members' experiences of the organization. Although findings are preliminary, they provide critical information on a potentially important therapeutic resource. More rigorous research with larger and more diverse samples of Latinos participating in CQ is warranted.

This study was undertaken to explore the perception of Year IV and Year V University of Malaya dental students on different domains related to the competency based test (CBT). Methodology: A questionnaire was constructed and a survey conducted to explore the students’ perception on four domains related to the competency test: 1) benefits, 2) readiness to take, 3) timing and 4) lecturers’ supervision. Results: In general, majority of the students agreed that they benefited from the competency test and felt adequately prepared for each test. Students’ agreeing on feeling confident to sit for each test ranged from 70.0%- 81.4% for Year IV and 45.1%-70.4% for Year V. Majority of Year IV and Year V students perceived that the timing of each competency test was ‘just right’. There was a high response of ‘Strongly agree/agree’ to availability of patients for practice and assessment, self-confidence and amount and distribution of clinical session as factors affecting when they take the CBT. Majority of Year IV students agreed that the assessment of lecturers was consistent for each tests while Year V had a high percentage of ‘Neutral’ response. Students’ agreeing that there was feedback after the test was 52.9%-71.4% for Year IV and 31.0%-56.5% for Year V. ‘Strongly agree/agree’ response of 68.6%-75.0% for Year IV and 36.6%-52.1% for Year V was recorded for the level of supervision being the same after passing the test. Conclusion: Overall, majority of students gave positive perception towards CBT in relation to four main domains explored in this research.

The International Fusion Materials Irradiation Facility (IFMIF) has a D -Li neutron stripping source that provides typical fusion irradiation conditions for material testing. The Liquid Breeder Validation Module (LBVM) is one of the medium flux test modules of the IFMIF that is used to account for some of the DEMO liquid breeder blanket R&D needs. Previous analyses have shown that the main irradiation parameters (He (appm)/dpa and H (appm)/dpa) in the medium flux area of the IFMIF can be improved to fit the expected parameters in the DEMO reactor for functional materials of liquid breeder blankets. Therefore, the design of an additional module, called the Neutron Spectral Shifter (NSS), has been considered to optimize the irradiation conditions of LBVM experiments. The proposed concept consists of supported tungsten plates working as a shifter material inside a steel structure. This design assures the mechanical integrity of the different components and it fulfills the neutronic requirements as well as the cooling capability. This present paper summarizes the work devoted to the design of the LBVM Neutron Spectral Shifter as well as the results of neutronic, thermo-hydraulic, mechanical and safety studies carried out to validate the design.

The beam dump of the LIPAc consists of a long and thin copper cone where the ions are stopped, cooled by water flowing along its outer surface. The high water velocity (between 4 and 8 m/s) and the turbulent regimes involved may compromise the mechanical stability of the slender beam dump structure and cause damages due to flow induced vibrations. Since the system is too complex to be studied theoretically, some tests have been carried out to evaluate its behavior in normal operating conditions. These tests, performed on a model built at 1:1 scale and replicating exactly the final version, have been focused on finding experimentally the main vibration modes and the responses to the different working flow rates. This modal analysis, together with the results of the measurements of the vibration characteristics obtained at several positions of the cone, is presented here. With amplitudes not greater than 500 mg rms in any case, the structure has proved its practical immunity to flow induced vibrations, thus validating its design and construction methodology.

The Liquid Breeder Validation Module (LBVM) will be one of the medium flux irradiation modules of the International Fusion Materials Irradiation Facility (IFMIF) neutron source. The objective of this module – presently under design – is the test of functional materials related to liquid breeders for future nuclear fusion power reactors (DEMO). This paper aims to describe the activation analyses performed to estimate the radioactive inventory and the expected contact dose from the activated materials of the module following a 345 day irradiation period. These calculations supply valuable information for different aspects related to the design of the module, such as the safety evaluation and the waste management and disassembly plan. The neutron transport calculations have been performed using the McDeLicious code. The ACAB nuclear inventory code, with the activation nuclear libraries EAF-2007, has been used for the activation analyses. The main results point out that the contact dose of the LBVM materials is much higher than the hands-on-limits, as expected. Therefore, remote handling operations are requested for disassembling the module. It is important to remark that after 8 h decay time, the contact dose rate of the LBVM decreases 76% for the EUROFER steel components and 46% for the 316 LN components. Regarding the isotopic inventory, although the main activation comes from the module steel structures, the production of tritium and Po-210 in the lithium lead inside the experimental capsules deserved a careful analysis.

Moral engagement in the setting of drug addiction is often at odds with prevailing moral discourse and is treated in punitive terms. In this article, I explore how one moral gesture—a promise between a heroin-using mother and daughter—embodies the difficulty and ambiguity of moral experience in the context of addiction and offers insight into how it is profoundly shaped by social processes. By offering a close description of the promise over time, I show how morality is lived through sentiments and practices of care and commitment, which are vulnerable to isolation, punishment, and wounding. The story of the promise thus offers a way to reflect upon morality as the blurring of these different intensities.