599 results on '"Andrew Campbell"'
Search Results
102. Pinchuk maps and function fields
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Andrew Campbell, L.
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- 2014
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103. Does Implant Selection Affect Patient-Reported Outcome Measures After Primary Total Hip Arthroplasty?
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Alison K. Klika, Andrew Campbell, Ahmed K. Emara, and Nicolas S. Piuzzi
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Male ,medicine.medical_specialty ,Arthroplasty, Replacement, Hip ,Minimal Clinically Important Difference ,Osteoarthritis ,Prom ,Osteoarthritis, Hip ,Odds ,medicine ,Humans ,Orthopedics and Sports Medicine ,Patient Reported Outcome Measures ,Prospective Studies ,Aged ,Pain Measurement ,Pain, Postoperative ,business.industry ,Minimal clinically important difference ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Arthralgia ,Confidence interval ,Treatment Outcome ,Physical therapy ,Female ,Surgery ,Patient-reported outcome ,Hip Prosthesis ,Implant ,business ,Follow-Up Studies - Abstract
Background Total hip arthroplasty (THA) is a reliable operation, but it is critical that orthopaedic surgeons characterize which surgical factors influence patient-reported outcomes. The purpose of this study was to determine whether implant selection at the time of THA affects the odds of having (1) inadequate improvement according to patient-reported pain, function, and activity; (2) failure to achieve a substantial clinical benefit (SCB) with respect to pain; or (3) failure to achieve a patient-acceptable symptomatic state (PASS) according to pain and function. Methods Prospective data were collected from 4,716 patients who underwent primary THA (from July 2015 to August 2018) in a single health-care system with standardized care pathways. Patients were categorized according to the type of femoral and acetabular components and bearing surface used. Outcomes included 1-year postoperative patient-reported outcome measures (PROMs) and improvement in the Hip disability and Osteoarthritis Outcome Score (HOOS) and the University of California at Los Angeles (UCLA) activity score. Inadequate improvement was defined as PROMs that changed by less than the minimal clinically important difference (MCID) for the HOOS pain and physical function short form (PS) and as failure to improve beyond a mostly homebound activity status for the UCLA activity score (a score of ≤3). The MCID and SCB thresholds were set at values reported in the literature. Results One-year PROM data were available for 3,519 patients (74.6%). There were no differences in the proportion of patients who attained the MCID in terms of HOOS pain, HOOS PS, or UCLA activity scores at 1 year for all analyzed implant parameters. Multivariate regression demonstrated that implant selection was not a significant driver of inadequate improvement, according to HOOS pain and HOOS PS (p > 0.05). Larger (36-mm) femoral heads demonstrated lower odds of inadequate improvement versus 28-mm femoral heads according to UCLA activity scores (odds ratio [OR]: 0.64; 95% confidence interval, 0.47 to 0.86; p = 0.003). Implant-related criteria were not significant drivers of attaining a PASS or achieving an SCB with respect to HOOS pain. Conclusions For the most part, THA implant characteristics are not drivers of inadequate improvement with respect to pain and function. Surgeons should utilize implants with an acceptable track record that allow stable fixation and restoration of hip biomechanics. Level of evidence Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence. more...
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- 2021
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104. Teledermatology in the provision of biologics through COVID‐19 in a rural dermatology practice—A retrospective review.
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Wong, Xin Lin, Farrell, Joshua Alexander, Satchell, Andrew Campbell, and Sebaratnam, Deshan Frank
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RETROSPECTIVE studies ,DERMATOLOGY ,COVID-19 ,BIOLOGICALS ,DERMATOLOGISTS ,RURAL health services - Abstract
COVID‐19 compounded existing barriers to healthcare for rural patients. We completed a retrospective chart review of patients receiving Pharmaceutical Benefits Scheme subsidised biologics at a Modified Monash Model 3 dermatology practice during the pandemic and examined factors contributing to successful continuation of care, particularly teledermatology. Our experience is instructive in the provision of medical dermatology to regional patients. [ABSTRACT FROM AUTHOR] more...
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- 2023
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105. Online Group Counseling for Young People Through a Customized Social Networking Platform: Phase 2 of Kids Helpline Circles
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Krestina Amon, Brad Ridout, Rowena Forsyth, and Andrew Campbell
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Human-Computer Interaction ,Counseling ,Mental Health ,Social Psychology ,Adolescent ,Communication ,Surveys and Questionnaires ,Humans ,General Medicine ,Anxiety ,Applied Psychology ,Computer Science Applications ,Social Networking - Abstract
There is a growing need for high-quality evidence to support the efficacy of online counseling and peer support via social networking sites (SNSs) as an intervention to reduce mental health symptoms in young people. This article presents Phase 2 of Kids Helpline (KHL) Circles, which used mixed methods to assess the acceptability, safety, user experience, and mental health benefits of a purpose-built, counselor-facilitated SNS. Young people aged 13-25 years ( more...
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- 2022
106. On-Table Verification of Aortopulmonary Shunt Patency Through Ipsilateral Pulmonary Venous Blood Flow Assessment by Transesophageal Echocardiography
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Amr Abolwafa, Andrew Campbell, and Madan Mohan Maddali
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Surgical repair ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Surgical team ,medicine.diagnostic_test ,business.industry ,Hemodynamics ,Doppler echocardiography ,medicine.disease ,Shunt (medical) ,Anesthesiology and Pain Medicine ,Internal medicine ,Venous blood flow ,Cardiology ,Medicine ,Shunt patency ,Cardiology and Cardiovascular Medicine ,business ,Pulmonary atresia - Abstract
Intraoperative transesophageal echocardiography is a well-established modality for the evaluation of the adequacy of the surgical repair of complex congenital heart lesions. This case report highlights the important role played by real-time transesophageal echocardiography during the evaluation of the patency of a left modified Blalock-Taussig shunt in a child with pulmonary atresia, nonconfluent pulmonary arteries, and borderline hemodynamic/ventilator parameters. Changes observed in the pulmonary venous blood flow pattern provided reassurance to the surgical team about the patency of the shunt and thereby avoided its reconstruction. more...
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- 2021
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107. Impact of Racial Disparities and Demographic Factors on Presentation, Treatment, and Survival Amongst Patients with Hodgkin Lymphoma
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Alexander Didier, Ying Ning, Andrew Campbell, and Danae M Hamouda
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Immunology ,Cell Biology ,Hematology ,Biochemistry - Published
- 2022
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108. Consensus definition of essential, optimal, and suggested components of a pediatric Sickle Cell Disease Center
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Monica L. Hulbert, Deepa Manwani, Emily Meier, Ofelia Alvarez, R. Clark Brown, Michael U. Callaghan, Andrew Campbell, Thomas Coates, Melissa Frei-Jones, Jane Hankins, Matthew Heeney, Lewis Hsu, Jeffrey Lebensburger, Charles Quinn, Nirmish Shah, Kim Smith-Whitley, Courtney Thornburg, and Julie Kanter more...
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Sickle cell disease (SCD) requires coordinated, specialized medical care for optimal outcomes. There are no United States (US) guidelines that define a pediatric comprehensive SCD program. We report a modified Delphi consensus-seeking process to determine essential, optimal, and suggested elements of a comprehensive pediatric SCD center. Nineteen pediatric SCD specialists participated from the US. Consensus was predefined as 2/3 agreement on each element’s categorization. Twenty-six elements were considered essential (required for guideline-based SCD care), ten were optimal (recommended but not required), and five were suggested. This work lays the foundation for a formal recognition process of pediatric comprehensive SCD centers. more...
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- 2022
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109. CAN ISOLATED VENTRICULAR INVERSION SURVIVE WITHOUT ATRIAL OR VENTRICULAR SEPTAL DEFECT?- CASE REPORT
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Pranav Kandachar, Eapen Thomas, Areej Al Maskary, and Andrew Campbell
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Background: Isolated ventricular inversion is characterized by atrioventricular discordance and ventriculoarterial concordance, clinically akin to transposition of the great arteries. In the absence of a significant atrial or ventricular septal defect, profound cyanosis is expected at birth. Case Report: A 5-month-old infant with isolated ventricular inversion presented with mild cyanosis. The left sided tricuspid valve straddled the interventricular septum with a closed interventricular communication, a type of “Double Outlet Left Atrium with three atrioventricular valves”, which provided the necessary ‘left to right’ shunt while severe regurgitation through the straddling segment and a patent ductus arteriosus provided the effective pulmonary blood flow. Result: The infant underwent atrial septectomy, closure of the leaky accessory orifice and a Damus-Kaye-Stansel anastomosis and a bidirectional Glen operation. Conclusion: A unique natural mechanism permitting survival in a child with transposition physiology is described. The Damus procedure preserved tricuspid valve, right ventricle and pulmonary valve function. more...
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- 2022
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110. Counternarratives of Pain and Suffering as Critical Pedagogy
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Ardavan Eizadirad, Andrew Campbell, and Steve Sider
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- 2022
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111. Fe5S2 identified as a host for sulfur in Earth and planetary cores
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Claire Zurkowski, Barbara Lavina, Abigail Case, Kellie Swadba, Stella Chariton, Vitali Prakapenka, and Andrew Campbell
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Cosmochemical considerations suggest that sulfur is a candidate light alloying element in rocky planetary cores, such that the high pressure-temperature (P-T) Fe-S phase relations likely play a key role in planetary core crystallization thermodynamics. The iron-saturated Fe-S phase relations were investigated to 200 GPa and 3250 K using combined powder and single-crystal X-ray diffraction techniques in a laser-heated diamond anvil cell. Upon heating at 120 GPa, I-4 Fe3S is observed to break down to form iron and a novel hexagonal Fe5S2 sulfide with the Ni5As2 structure (P63cm, Z = 6). To 200 GPa, Fe5S2 and Fe are observed to coexist at high temperatures while Fe2S polymorphs are identified with Fe at lower temperatures. An updated Fe-rich Fe-S phase diagram is presented. As this hexagonal Fe5S2 expresses complex Fe-Fe coordination and atomic positional disorder, crystallization of Fe5S2 may contribute to intricate elastic and electrical properties in Earth and planetary cores as they crystallize over time. Models of a fully crystallized Fe-rich Fe-S liquid in Earth’s and Venus’ core establish that Fe5S2 is likely the only sulfide to crystallize and may deposit in the outer third of the planets’ cores as they cool. Fe5S2 could further serve as a host for Ni and Si as has been observed in the related meteoritic phase perryite, (Fe, Ni)8(P, Si)3, adding intricacies to elemental partitioning during core crystallization. The stability of Fe5S2 presented here is key to understanding the role of sulfur in the crystallization sequences that drive the geodynamics and dictate the structures of Earth and rocky planetary cores. more...
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- 2022
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112. The asymptotic variety of a Pinchuk map as a polynomial curve.
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L. Andrew Campbell
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- 2011
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113. COVID Student Study: A Year in the Life of College Students during the COVID-19 Pandemic Through the Lens of Mobile Phone Sensing
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Subigya Nepal, Weichen Wang, Vlado Vojdanovski, Jeremy F Huckins, Alex daSilva, Meghan Meyer, and Andrew Campbell
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- 2022
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114. Parents’ Experiences and Needs Regarding Infant Sickle Cell Trait Results
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Alexandra M. Sims, Shamaree J. Cromartie, Lelia Gessner, Andrew Campbell, Tumaini Coker, C. Jason Wang, and Beth A. Tarini
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Counseling ,Parents ,Adolescent ,Infant, Newborn ,Infant ,Articles ,Disclosure ,Sickle Cell Trait ,Neonatal Screening ,surgical procedures, operative ,immune system diseases ,hemic and lymphatic diseases ,Pediatrics, Perinatology and Child Health ,Humans ,Child ,therapeutics ,human activities - Abstract
BACKGROUND AND OBJECTIVE Sickle cell trait (SCT) has reproductive implications and can rarely cause health problems. SCT counseling improves parent knowledge but is infrequently received by children with SCT compared with children with cystic fibrosis carrier status. There are no national guidelines on SCT disclosure timing, frequency, or counseling content. Parents’ experiences with SCT disclosure and counseling are poorly understood but could inform the development of guidelines. We explored parents’ experiences with and desires for SCT disclosure and counseling for their infants with SCT identified via newborn screening. METHODS Parents of infants 2 to 12 months old with SCT were recruited through a state newborn screening program for semistructured interviews to explore their experiences with and desires for SCT disclosure and counseling. Inductive thematic analysis was conducted. RESULTS Sixteen interviews were completed from January to August 2020. Most parents reported that SCT disclosure occurred soon after birth, in person, and by the child’s physician. Five themes were identified: parent knowledge before child’s SCT disclosure, family planning, the dynamics of SCT disclosure and counseling, emotions and actions after SCT disclosure, and parent desires for the SCT disclosure and counseling process. Two primary parent desires were revealed. Parents want more information about SCT, particularly rare symptomatology, and they want SCT counseling repeated once the child approaches adolescence. CONCLUSION Parents report receiving their child’s SCT diagnosis in the early newborn period from their child’s doctor but indicate they receive incomplete information. Opportunities exist in primary care pediatrics to better align SCT disclosure timing and counseling content with parent desires. more...
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- 2022
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115. Excitation and sensing of Lamb waves in very thin metals and nuclear cladding material using fully non-contact PL-SLDV system
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Elsa Compton, Andrew Campbell, Pei-Kang Sun, and Lingyu Yu
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- 2022
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116. Design and application of an engineered composite patch toward crack damage mitigation on stainless steel plates
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Pei-Kang Sun, Andrew Campbell, Elsa Compton, Yuh-Jin Chao, and Lingyu Yu
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- 2022
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117. RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells
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Ahmet Ucar, Fuhui Chen, David Novo, Denis Alferez, Kyriaki Pavlou, Jingwei Zhang, Secil Eroglu, Neil Humphreys, Antony Adamson, Andrew Campbell, Cathy Tournier, Robert (B.) Clarke, Keith Brennan, and Charles Streuli more...
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Breast cancer stem cells (BCSC) are presumed to be responsible for treatment resistance, tumor recurrence and metastasis of breast tumors. However, development of BCSC-targeting therapies has been held back by their heterogeneity and the lack of BCSC-selective molecular targets. Here, we demonstrate that Rac1b, the only known alternatively spliced variant of the small GTPase Rac1, is expressed in a subset of BCSCs in vivo and its function is required for the BCSC maintenance and the chemoresistance of breast tumor cells. In human breast cancer cell line MCF7, RAC1B is required for BCSC plasticity and chemoresistance in vitro and for tumor-initiating abilities in vivo. Unlike Rac1, Rac1b function is dispensable for normal mammary gland development and mammary epithelial stem cell (MaSC) activity. In contrast, loss of Rac1b function in a mouse model of breast cancer hampers BCSC activity in vivo and increases the chemosensitivity of primary tumor cells to doxorubicin. Collectively, our data suggest that RAC1B is a clinically relevant molecular target for the development of BCSC-targeting therapies that will improve the effectiveness of currently available chemotherapy modalities. more...
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- 2022
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118. Healthy plant-based diets and their short-term effects on weight loss, nutrient intake and serum cholesterol levels
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Laura Brown, Kelly Rose, and Andrew Campbell
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Eating ,Nutrition and Dietetics ,Cholesterol ,Diet, Vegetarian ,Weight Loss ,Medicine (miscellaneous) ,Humans ,Female ,Energy Intake ,Sugars ,Dietary Fats - Abstract
Healthy plant-based diets (hPBD) are being promoted to reduce the risks of cardiovascular and associated diseases. This study investigates short-term adherence to a hPBD to examine whether these dietary changes impact weight and cardiovascular risk factors. A simple, uncontrolled, before and after design was used. Twenty women (mean BMI 31 ± 4 kg/m more...
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- 2022
119. Safety and efficacy of voxelotor in pediatric patients with sickle cell disease aged 4 to 11 years
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Jeremie H. Estepp, Ram Kalpatthi, Gerald Woods, Sara Trompeter, Robert I. Liem, Kacie Sims, Adlette Inati, Baba P. D. Inusa, Andrew Campbell, Connie Piccone, Miguel R. Abboud, Kim Smith‐Whitley, Sandra Dixon, Margaret Tonda, Carla Washington, Noelle M. Griffin, and Clark Brown more...
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Male ,Hemoglobin, Sickle ,Hematology ,Anemia, Sickle Cell ,Hemolysis ,Oncology ,Benzaldehydes ,Child, Preschool ,Pyrazines ,Pediatrics, Perinatology and Child Health ,Humans ,Pyrazoles ,Female ,Child ,Biomarkers - Abstract
Sickle cell disease (SCD) is a devastating, multisystemic disorder that affects millions of people worldwide. The earliest clinical manifestations of SCD can affect infants as young as 6 months of age, and pediatric patients are at risk for acute and life-threatening complications. Early intervention with treatments that target the underlying pathophysiological mechanism of SCD, sickle hemoglobin (HbS) polymerization, are expected to slow disease progression and circumvent disease-associated morbidity and mortality.The HOPE-KIDS 1 trial (NCT02850406) is an ongoing four-part, phase 2a, open-label, single- and multiple-dose study to evaluate the pharmacokinetics, efficacy, and safety of voxelotor-a first-in-class HbS polymerization inhibitor-in patients aged 6 months to 17 years with SCD. Initial findings from a cohort of 45 patients aged 4 to 11 years who received voxelotor treatment for up to 48 weeks are reported.Hemoglobin (Hb) response, defined as a1.0 g/dl increase from baseline, was achieved at week 24 by 47% (n = 16/34) of patients with Hb measurements at baseline and week 24. At week 24, 35% (n = 12/34) and 21% (n = 7/34) of patients had a1.5 g/dl increase and a2.0 g/dl increase from baseline in Hb concentration, respectively. Concurrent improvements in hemolytic markers were observed. Voxelotor was well tolerated in this young cohort, with no newly emerging safety signals.Based on its mechanism as an HbS polymerization inhibitor, voxelotor improves Hb levels and markers of hemolysis and has the potential to mitigate SCD-related complications; these results support its use in patients aged ≥4 years. more...
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- 2022
120. Nondestructive Evaluation of Stress Corrosion Cracking in a Welded Steel Plate Using Guided Ultrasonic Waves
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Zhaoyun Ma, Lingyu Yu, Yuh J. Chao, Poh-Sang Lam, Robert L. Sindelar, Andrew J. Duncan, Thanh-Tam Truong, Christopher Verst, Pei-Kang Sun, and Andrew Campbell
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Mechanics of Materials ,Safety, Risk, Reliability and Quality ,Civil and Structural Engineering - Abstract
Stress corrosion cracking (SCC) had occurred in early-generation high-level nuclear waste tanks constructed by welding carbon steel. This paper describes an ultrasonic inspection system and its fundamental ability to detect and quantify the length of SCC on thick welded steel plates. The finite element method (FEM) was applied to simulate the welding process to estimate the welding residual stress field. Growth of stress corrosion cracks is driven by crack stress intensities exceeding the subcritical cracking threshold intensity. The subject plate was experimentally inspected with ultrasonic nondestructive evaluation (NDE) techniques to characterize the extent of SCC. The NDE system uses a piezoelectric transducer to generate guided waves in the thick steel plate, and a scanning laser Doppler vibrometer (SLDV) to measure multidimensional time–space wavefield data over a user-defined scanning area in the plate surface. The measured wavefield data can show wave interactions in a localized area in the plate due to the presence of the discontinuities of the SCC. To generate an inspection image that can precisely show the crack’s location and/or the dimension, the wavefield data are further processed to generate inspection image that maps the entire sample plate so the crack can be clearly identified in the plate while its length can be readily estimated. The ultrasonic test results for crack length agree well with the visually estimated length and are close to that predicted by the FEM for cracks in the weld residual stress field. more...
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- 2022
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121. Three waves of COVID-19 in a Norwegian local hospital
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Marius, Myrstad, Peter Selmer, Rønningen, Anders, Tveita, Else Johanne, Rønning, Per Erik, Ernø, Elizabeth Lyster, Andersen, Marte Meyer, Walle-Hansen, Andrew Campbell, Robertson, Monica, Thallinger, Jan, Svendsen, Sigurd, Haakonsen, Arnljot, Tveit, and Håkon, Ihle-Hansen more...
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Hospitalization ,SARS-CoV-2 ,COVID-19 ,Humans ,Pandemics ,Hospitals ,Aged - Abstract
The objective of this article is to summarise the course of illness and treatment for patients with COVID-19 admitted to Bærum Hospital since the start of the pandemic.We present data from a prospective observational study with the aim of systematising knowledge about patients admitted because of COVID-19. All patients admitted to Bærum Hospital up to and including 28 June 2021 were included. The results are presented for three waves of admissions: 9 March-23 June 2020, 21 September 2020-28 February 2021 and 1 March-28 June 2021.A total of 300 patients, divided into 77, 101 and 122 in the three waves respectively, were admitted because of COVID-19. The number of hospital deaths during the three waves was 14 (18 %), 11 (11 %) and 5 (4 %) respectively. The average age of the patients was 67.6 years in the first wave and 53.3 years in the third wave. Altogether 204 patients (68 %) received medical oxygen or ventilation support, and 31 of these (10 % of all the patients) received invasive ventilation support. Non-invasive ventilation support was used as the highest level of treatment in 4 (8 %), 9 (13 %) and 17 (20 %) patients with respiratory failure in the three waves respectively. In the second and third wave, 125 out of 152 patients with respiratory failure (82 %) were treated with dexamethasone.Differences in patient characteristics and changes to treatment methods, such as the use of dexamethasone and non-invasive ventilation support, may have contributed to the apparent fall in mortality from the first to the third wave. Conditions that are not registered in the study, such as vaccination status, may also have impacted on mortality. more...
- Published
- 2022
122. Can the semiempirical PM3 scheme describe iron-containing bioinorganic molecules?
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Jonathan P. McNamara, Mahesh Sundararajan, Ian H. Hillier, Jun Ge, Andrew Campbell, and Claudio Morgado
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- 2006
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123. The asymptotic variety of a Pinchuk map as a polynomial curve
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Andrew Campbell, L.
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- 2011
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124. Preface.
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Mary Czerwinski, Oscar Mayora, Paul Lukowicz, Andrew Campbell 0001, and Venet Osmani
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- 2013
125. Subject satisfaction and psychological well-being with escalating abobotulinumtoxinA injection dose for the treatment of moderate to severe glabellar lines
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Steven Dayan, John Joseph, Amir Moradi, Z. Paul Lorenc, Kyle Coleman, Glynis Ablon, Joely Kaufman‐Janette, Sue Ellen Cox, Andrew Campbell, Girish Munavalli, and Inna Prygova
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Adult ,Male ,Treatment Outcome ,Double-Blind Method ,Neuromuscular Agents ,Patient Satisfaction ,Humans ,Female ,Dermatology ,Forehead ,Personal Satisfaction ,Botulinum Toxins, Type A ,Skin Aging - Abstract
Previous studies indicate that the efficacy and durability of a single AbobotulinumtoxinA (ABO) treatment for moderate to severe glabellar lines may be enhanced with increasing dose, while safety outcomes remain consistent with those of the licensed dose (50 U).Evaluation of subject-reported indicators of treatment efficacy, satisfaction, and psychological well-being with ABO dose escalation.A Phase 2, 36-week, multicenter, randomized, dose-ranging, double-blind, placebo-controlled study was conducted in adults with moderate to severe glabellar lines. Subjects received a single ABO treatment, dosed at 50, 75, 100, or 125 U, or placebo. Efficacy endpoints comprised subject-assessed improvement in line severity of ≥1-grade from baseline at maximum frown, global aesthetic improvement scale (GAIS) grade, FACE-Q™ appraisal of lines, psychological well-being and age, and subject satisfaction.The study included 399 subjects (88.2% were female). Respective responder rates (≥1-grade improvement) with ABO 50-125 U doses ranged between 96.3%-100% at Week 4, 65.0%-67.9% at Week 24, and 33.8%-44.4% at Week 36. GAIS responder rate and FACE-Q appraisal of lines showed a similar pattern of change. Satisfaction was high and psychological well-being was improved from Week 4 through Week 36, with natural, youthful, and refreshed appearance reported for all ABO doses.A single ABO treatment (dosed at 50-125 U) provided significant and sustained improvements in glabellar line severity over durations up to 36 weeks, versus placebo. Treatment satisfaction was high with all doses. Participants reported natural and youthful appearance, alongside improvements in psychological well-being. more...
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- 2022
126. The Intertwined Well-Being of Children and Non-Human Animals: An Analysis of Animal Control Reports Involving Children
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Andrew Campbell
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General Social Sciences ,animal cruelty ,child abuse ,family violence ,animal control ,community partnerships ,law enforcement ,cross-reporting ,companion animals ,wild animals - Abstract
The well-being of children and non-human animals (subsequently referred to as animals) is often intertwined. Communities are unlikely to be able to best protect humans from abuse and harm unless they are working to ensure the safety of animals who reside there as well. This study is the first to utilize U.S. animal control report data and narratives to explore how children are involved in cases of animal cruelty. Children engage in abusive acts toward animals, alone, or along with peers and/or adults. Children were found to inflict abuse most often with their hands or feet as opposed to with a weapon or other object. A total of 85% of animal cruelty perpetrated by children was toward a dog or cat. Key differences between how children are involved in acts of cruelty to companion animals compared with acts involving wild animals are described and warrant further study. The cases of animal abuse or neglect reported by children were among the most severe in the study, and often involved an adult perpetrator known to the child. Neighbors rarely report child abuse or intimate partner violence in the United States, but 89% of the animal cruelty cases involving children in this study were reported by a neighbor or passerby. Although children involved in reports as a perpetrator or reporter were most often in early adolescence, children involved in cross-reports between child welfare and animal control were often under the age of 5. Improved cross-reporting and stronger partnerships between human and animal welfare agencies may provide opportunity for earlier intervention and is likely to better many human and animal lives. more...
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- 2022
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127. Spectrum of heavy-tailed elliptic random matrices
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Andrew Campbell and Sean O’Rourke
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Statistics and Probability ,Statistics, Probability and Uncertainty - Published
- 2022
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128. The Patient with Acute Abdominal Pain
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Andrew Campbell and Poonam Mohan Shenoy
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- 2022
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129. Tre bølger med covid-19 på et norsk lokalsykehus
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Håkon Ihle-Hansen, Arnljot Tveit, Sigurd Haakonsen, Jan Svendsen, Monica Thallinger, Andrew Campbell Robertson, Marte Meyer Walle-Hansen, Elizabeth Lyster Andersen, Per Erik Ernø, Else Johanne Rønning, Anders Tveita, Peter Selmer Rønningen, and Marius Myrstad more...
- Subjects
General Medicine - Abstract
BAKGRUNN Formålet med artikkelen er å oppsummere sykdomsforløp og behandling for pasienter med covid-19 innlagt på Bærum sykehus siden starten av pandemien. MATERIALE OG METODE Vi presenterer data fra en prospektiv observasjonsstudie med mål om å systematisere kunnskap om pasienter innlagt på grunn av covid-19. Alle pasienter innlagt på Bærum sykehus til og med 28.6.2021 ble inkludert. Resultatene presenteres for tre bølger av sykehusinnleggelser: 9.3.–23.6.2020, 21.9.2020–28.2.2021 og 1.3.–28.6.2021. RESULTATER I alt 300 pasienter, fordelt på hhv. 77, 101 og 122 i de tre bølgene, var innlagt på grunn av covid-19. Antallet som døde under sykehusoppholdet i de tre bølgene, var hhv. 14 (18 %), 11 (11 %) og 5 (4 %). Gjennomsnittsalderen for innlagte var 67,6 år i første bølge og 53,3 år i tredje bølge. Totalt 204 pasienter (68 %) fikk oksygenbehandling eller ventilasjonsstøtte, og 31 av disse (10 % av alle pasientene) fikk invasiv ventilasjonsstøtte. Ikke-invasiv ventilasjonsstøtte ble brukt som høyeste nivå av behandling hos hhv. 4 (8 %), 9 (13 %) og 17 (20 %) pasienter med respirasjonssvikt i de tre bølgene. I andre og tredje bølge fikk 125 av 152 pasienter med respirasjonssvikt (82 %) behandling med deksametason. FORTOLKNING Forskjeller i pasientkarakteristika og endringer i behandling, som i bruk av deksametason og ikke-invasiv ventilasjonsstøtte, kan ha bidratt til at dødeligheten tilsynelatende sank fra første til tredje bølge. Forhold som ikke er registrert i studien, slik som vaksinasjonsstatus, kan også ha påvirket dødeligheten. more...
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- 2022
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130. Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGFβ signalling pathway
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Christos Kiourtis, Maria Terradas-Terradas, Lucy M. Gee, Ya-Ching Hsieh, Colin Nixon, William Clark, Robin Shaw, Peter S. Hanson, David Sumpton, Gillian Mackay, Stephanie May, Miryam Müller, Arafath K. Najumudeen, Andrew Campbell, Simon T. Barry, Christopher M. Morris, Fiona E. N. LeBeau, Owen J. Sansom, Kristina Kirschner, Fiona Oakley, and Thomas G. Bird more...
- Abstract
Cellular senescence is associated with aging but also impacts various physiological and pathological processes such as embryonic development and wound healing. Factors secreted by senescent cells can affect their microenvironment, including local spreading of senescence. Acute severe liver disease is associated with hepatocyte senescence and frequently progresses to multi-organ failure. Why the latter occurs is poorly understood. Here, using genetic mouse models of hepatocyte-specific senescence, we demonstrate senescence development in extrahepatic organs and associated organ dysfunction in response to liver senescence. Additionally, we observe senescence-associated regeneration and reprogramming in the proximal tubules of the kidney. Using single cell transcriptomics and in vitro assays, we identify the Transforming Growth Factor β (TGFβ) pathway as a critical mediator of systemic spread of senescence. Lastly, TGFβ inhibition in our mouse models blocks senescence transmission to other organs and prevents renal dysfunction. Our results highlight the systemic consequences of organ-specific senescence which, independent of aging, contributes to multi-organ dysfunction. more...
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- 2021
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131. Subject Satisfaction With AbobotulinumtoxinA for Moderate-to-Severe Glabellar Lines: A Randomized, Dose-Escalation, Double-Blind Study
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Amir Moradi, Steven Dayan, John Joseph, Z. Paul Lorenc, Kyle Coleman, Glynis Ablon, Joely Kaufman-Janette, Sue Ellen Cox, Andrew Campbell, and Girish Munavalli
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Toxicology - Published
- 2022
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132. Functional movement disorder: a long journey to diagnosis
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Bharadwaj, Sneha, Lee, Melissa, and Moffat, Andrew Campbell
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- 2015
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133. Supply of Software: Copyright and Contract Issues.
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Diane Rowland and Andrew Campbell
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- 2002
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134. Think Again: Why Good Leaders Make Bad Decisions and How to Keep it From Happeining to You
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Sydney Finkelstein, Jo Whitehead, Andrew Campbell
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- 2009
135. Tre bølger med covid-19 på et norsk lokalsykehus
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Myrstad, Marius, primary, Rønningen, Peter Selmer, primary, Tveita, Anders, primary, Rønning, Else Johanne, primary, Ernø, Per Erik, primary, Andersen, Elizabeth Lyster, primary, Walle-Hansen, Marte Meyer, primary, Robertson, Andrew Campbell, primary, Thallinger, Monica, primary, Svendsen, Jan, primary, Haakonsen, Sigurd, primary, Tveit, Arnljot, primary, and Ihle-Hansen, Håkon, primary more...
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- 2022
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136. Fe5S2 identified as a host for sulfur in Earth’s core
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Claire Zurkowski, Barbara Lavina, Abigail Case, Kellie Swadba, Stella Chariton, Vitali Prakapenka, and Andrew Campbell
- Abstract
Planetary habitability, as we experience on Earth, is linked to a functioning geodynamo which is in part driven by the crystallization of the liquid iron-nickel-alloy core as a planet cools over time. Cosmochemical considerations suggest that sulfur is a candidate light alloying element in rocky planetary cores of varying sizes and oxidation states; such that, iron sulfide phase relations at extreme conditions contribute to outer core thermochemical convection and inner core crystallization of a wide range of planetary bodies. Here we experimentally investigate the structural properties of the Fe-S system and report the discovery of the sulfide, Fe5S2, crystallizing in equilibrium with iron at Earth’s outer core pressures and high temperatures. Using single-crystal X-ray diffraction techniques, Fe5S2 was determined to adopt the complex Ni5As2-type structure (P63cm, Z = 6). These results conclude that Fe5S2 is likely to crystallize at the interface of Earth’s core and mantle and will begin to crystallize during the freezing out of Earth and Venus’ core overtime. The increased metal-metal bonding measured in Fe5S2 compared to the other high P-T iron sulfides may contribute to signatures of higher conductivity from regions of Fe5S2 is crystallization. Fe5S2 could serve as a host for Ni and Si as has been observed in the related meteoritic phase, perryite, (Fe, Ni)8(P, Si)3, adding intricacies to elemental partitioning during inner core crystallization. The stability of Fe5S2 presented here is key to understanding the role of sulfur in the multicomponent crystallization sequences that drive the geodynamics and dictate the structures of Earth and rocky planetary cores. more...
- Published
- 2021
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137. Killing Two Birds with One Stone: Developing Northern Australian Adaptive Capabilities to Sustainably Develop Competent and Thriving Communities Capable of Responding Effectively to Natural Hazards
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Alison Cottrell, Helen James, Douglas Paton, Andrew Campbell, and Petra Buergelt
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Natural hazard ,Thriving ,Sustainability ,Sociology ,Environmental planning - Published
- 2021
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138. Design for Liveability in Tropical Australia
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Edward Halawa, Andrew Campbell, Shokhida Safarova, and Lisa Law
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Economic growth ,Government ,Geography ,Quality of life (healthcare) ,business.industry ,Tropical australia ,High population ,business ,Quarter (United States coin) ,Accommodation - Abstract
[Extract:] In their agenda-setting book on the future of Australia cities, Weller and Bolleter (2013) contemplated Australia’s rapid and continual growth and its implications for the future Australian landscape. Setting views about a Big Australia to one side, these trends present Australian cities with some immutable challenges. Will Australians have to adapt to a deteriorating quality of life as cities accommodate this growth? Will the extra accommodation be built in the precincts where jobs are concentrated? Can cities grow to quarter more and more people without losing their liveability? Are there any special issues to consider in tropical Australia, a region that has experienced high population growth over the past decade and where the government has earmarked future development (Australian Government, 2014)? more...
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- 2021
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139. New Pathways for the Governance of Northern Development
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Peter Davies, Allan Dale, Alistar Robertson, Michael M. Douglas, Andrew Campbell, and Ruth Wallace
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Geography ,Corporate governance ,Public administration - Published
- 2021
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140. Timing and Climate: Rainfall Variability in Northern Australia
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Andrew Campbell, Sara Beavis, Tom Griffiths, and Chris O'Brien
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Geography ,Northern australia ,Physical geography - Published
- 2021
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141. AbobotulinumtoxinA for the Treatment of Moderate-to-Severe Glabellar Lines: A Randomized, Dose-Escalating, Double-Blind Study
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Glynis Ablon, Joely Kaufman-Janette, Amir Moradi, Kyle M. Coleman, Andrew Campbell, Steven H. Dayan, Z. Paul Lorenc, Girish Munavalli, John H Joseph, Sue Ellen Cox, and Anna-Karin Berg
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Moderate to severe ,Adult ,medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,General Medicine ,Placebo ,Skin Aging ,Double blind study ,Treatment Outcome ,Double-Blind Method ,Neuromuscular Agents ,Internal medicine ,ABO blood group system ,Clinical endpoint ,Medicine ,Humans ,Female ,Forehead ,Seroconversion ,Botulinum Toxins, Type A ,business ,Adverse effect - Abstract
OBJECTIVE To evaluate the efficacy and safety of AbobotulinumtoxinA (ABO) dose escalation in the correction of moderate-to-severe glabellar lines. DESIGN Phase 2, 36-week, multicenter, randomized, dose-ranging, double-blind, placebo-controlled study. METHODS Adults with moderate-to-severe glabellar lines received a single ABO treatment, dosed at 50, 75, 100, or 125 U, or placebo. Primary endpoint was week 4 composite ≥2-grade responder rate among those achieving a severity score of 0 (none) or 1 (mild) at maximum frown, evaluated using concurrent investigator and subject assessments. Secondary endpoints included ≥1-grade severity improvement, duration of effect, and reporting of treatment-emergent adverse events (TEAEs). RESULTS Overall, 399 subjects were included (88.2% were female). Week 4 composite ≥2-grade ABO responder rate was 80.0% (50 U), 88.8% (75 U), 90.0% (100 U) and 95.1% (125 U), versus 2.6% with placebo (P more...
- Published
- 2021
142. Amorphous solid dispersions: Utilization and challenges in preclinical drug development within AstraZeneca
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Akosua B. Anane-Adjei, Esther Jacobs, Samuel C. Nash, Sean Askin, Ramesh Soundararajan, Mary Kyobula, Jonathan Booth, and Andrew Campbell
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Drug Development ,Solubility ,Polymers ,Drug Compounding ,Pharmaceutical Science ,Water ,Crystallization - Abstract
The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates much of the early drug development portfolio and poses a major challenge in pharmaceutical development. Polymer-based amorphous solid dispersions (ASDs) are becoming increasingly common and offer a promising formulation strategy to tackle the solubility and oral absorption issues of these APIs. This review discusses the design, manufacture, and utilisation of ASD formulations in preclinical drug development, with a key focus on the pre-formulation assessments and workflows employed at AstraZeneca. more...
- Published
- 2021
143. Bank insolvency - recovery and resolution
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Andrew Campbell and P Moffatt
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Insolvency ,Resolution (electron density) ,Geology ,Remote sensing - Published
- 2021
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144. Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection
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William Domm, Min Yee, Jane E. Malone, Andrew Campbell, Rachel Warren, Terry W. Wright, Margot Mayer-Pröschel, and Michael A. O'Reilly
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0301 basic medicine ,Pulmonary and Respiratory Medicine ,Recurrent infections ,Physiology ,Ataxia Telangiectasia Mutated Proteins ,CD8-Positive T-Lymphocytes ,Immunological memory ,medicine.disease_cause ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Orthomyxoviridae Infections ,Physiology (medical) ,Influenza A virus ,Animals ,Ataxia telangiectasia mutated ,Medicine ,Recurrent respiratory infections ,Lung ,Gene ,Mice, Knockout ,business.industry ,Cell Biology ,medicine.disease ,Vaccination ,030104 developmental biology ,030228 respiratory system ,Mutation ,Immunology ,Ataxia-telangiectasia ,business ,Immunologic Memory ,Research Article - Abstract
Ataxia-telangiectasia (A-T), caused by mutations in the A-T mutated ( ATM) gene, is a neurodegenerative disorder affecting ∼1 in 40,000–100,000 children. Recurrent respiratory infections are a common and challenging comorbidity, often leading to the development of bronchiectasis in individuals with A-T. The role of ATM in development of immune memory in response to recurrent respiratory viral infections is not well understood. Here, we infect wild-type (WT) and Atm-null mice with influenza A virus (IAV; HKx31, H3N2) and interrogate the immune memory with secondary infections designed to challenge the B cell memory response with homologous infection (HKx31) and the T cell memory response with heterologous infection (PR8, H1N1). Although Atm-null mice survived primary and secondary infections, they lost more weight than WT mice during secondary infections. This enhanced morbidity to secondary infections was not attributed to failure to effectively clear virus during the primary IAV infection. Instead, Atm-null mice developed persistent peribronchial inflammation, characterized in part by clusters of B220+B cells. Additionally, levels of select serum antibodies to hemagglutinin-specific IAV were significantly lower in Atm-null than WT mice. These findings reveal that Atm is required to mount a proper memory response to a primary IAV infection, implying that vaccination of children with A-T by itself may not be sufficiently protective against respiratory viral infections. more...
- Published
- 2019
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145. A Multicenter Prospective Clinical Trial of 68Gallium PSMA HBED-CC PET-CT Restaging in Biochemically Relapsed Prostate Carcinoma: Oligometastatic Rate and Distribution Compared With Standard Imaging
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Michael McCarthy, Roslyn Francis, Joanne Watts, Colin Tang, and Andrew Campbell
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Cancer Research ,PET-CT ,medicine.medical_specialty ,Radiation ,Prostatectomy ,business.industry ,medicine.medical_treatment ,urologic and male genital diseases ,030218 nuclear medicine & medical imaging ,Targeted therapy ,Clinical trial ,Radiation therapy ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Oncology ,Prostate ,030220 oncology & carcinogenesis ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,Prospective cohort study ,Recurrent Prostate Carcinoma ,business - Abstract
Purpose The purpose of this study is to assess the utility of 68Gallium prostate-specific membrane antigen (PSMA) Division of Radiopharmaceutical Chemistry (DKFZ)-PSMA-11 positron emission tomography (PET)–computed tomography (CT), compared with standard imaging, in the detection of recurrent prostate carcinoma in patients with biochemical relapse to determine the prevalence of oligometastatic disease recurrence and its distribution. Methods and Materials This is a prospective, multicenter clinical trial of PSMA-HBED PET/CT imaging in patients with early biochemical relapse of prostate carcinoma (median prostate-specific antigen [PSA], 2.55 ng/mL) after definitive prostatectomy (152 patients) or radiation therapy (86 patients) with either no lesions or oligometastatic disease on abdominopelvic CT and bone scan (BS). PSMA-HBED PET/CT scan was performed within 8 weeks of restaging imaging, and all sites of abnormal PSMA-HBED binding determined as probable or definite for prostate carcinoma were included in the analysis. PSMA positivity was assessed for correlation with Gleason Score, PSA level, and PSA doubling time. Results Two hundred thirty-eight patients underwent PSMA-HBED PET/CT imaging. In 199 patients with no lesions on restaging CT and BS, 148 patients (74%) demonstrated PSMA-positive lesions, with 113 patients (57%) being oligometastatic. In 39 patients with oligometastatic lesions on restaging CT and BS, 19 patients (49%) were confirmed as oligometastatic on PSMA PET/CT and 16 patients (41%) were upstaged to polymetastatic. The 4 remaining patients (10%) with sites of possible metastatic disease were not confirmed as having prostate carcinoma. Combining the overall group, there were 183 patients (77%) with PSMA-HBED–positive lesions (682 lesions), suggesting prostate carcinoma, of whom 132 patients (55%) were oligometastatic. In the oligometastatic group, PSMA positivity was limited to the pelvis in 65% of patients, involving either the prostate or nodes (American Joint Committee on Cancer stage N1). This study found a positive correlation between PSMA-HBED positivity and PSA levels; no other factors were statistically significant. Conclusions For patients with biochemical relapse with BS and CT demonstrating either no disease or low-volume disease, there is a high overall prevalence of PSMA PET/CT–positive disease. More than half of the patients were oligometastatic, and of those, disease was confined to the pelvis in nearly two-thirds of patients. This result confirms that PSMA PET/CT is significantly more sensitive than standard restaging imaging, and it may be useful in identifying patients for subsequent targeted therapy. more...
- Published
- 2019
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146. Prescribing and Advanced Practice
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Andrew Campbell
- Subjects
Clinical governance ,Nursing ,business.industry ,Medicine ,Allied health professions ,business - Published
- 2019
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147. Biclonal presentation of lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia
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Pei Lin, Beverly Carol Handy, Wei Wang, Andrew Campbell, L. Jeffrey Medeiros, and Yi Ding
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Pathology ,medicine.medical_specialty ,business.industry ,Medicine ,Waldenström macroglobulinaemia ,Presentation (obstetrics) ,business ,Pathology and Forensic Medicine ,Lymphoplasmacytic Lymphoma - Published
- 2019
- Full Text
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148. Estimated SARS-CoV-2 Seroprevalence in Healthy Children and Those with Chronic Illnesses in the Washington Metropolitan Area as of October 2020
- Author
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Burak, Bahar, Joelle N, Simpson, Cara, Biddle, Andrew, Campbell, Jeffrey S, Dome, Roberta L, DeBiasi, Catriona, Mowbray, Stefanie, Marguilies, Adrienne, Sherman, Jacqueline, Reuben, and Meghan, Delaney more...
- Subjects
Male ,Adolescent ,Maryland ,Infant, Newborn ,Virginia ,COVID-19 ,Infant ,Hispanic or Latino ,West Virginia ,Antibodies, Viral ,Healthy Volunteers ,COVID-19 Serological Testing ,Young Adult ,Seroepidemiologic Studies ,Child, Preschool ,Immunoglobulin G ,Chronic Disease ,District of Columbia ,Humans ,Female ,Child - Abstract
The estimated severe acute respiratory syndrome coronavirus 2 seroprevalence in children was found to be 9.46% for the Washington Metropolitan area. Hispanic/Latinx individuals were found to have higher odds of seropositivity. While chronic medical conditions were not associated with having antibodies, previous fever and body aches were predictive symptoms. more...
- Published
- 2021
149. Prescribing in a pediatric hospital setting - Lost in translation?
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Benjamin Ware, David Sommerfield, Dean Huppatz, Rose Ann Ayes Medriano, Zahraa Al-Saeedy, Kenneth Lee, Britta S. von Ungern-Sternberg, Zainab Al Khayrallah, Andrew Campbell, Lee Yong Lim, and Aine Sommerfield more...
- Subjects
medicine.medical_specialty ,Prescription Drugs ,business.industry ,media_common.quotation_subject ,Australia ,Pharmacy ,Health literacy ,General Medicine ,Affect (psychology) ,Hospitals, Pediatric ,Terminology ,Presentation ,Family medicine ,Enabling ,medicine ,Humans ,Medication Errors ,Dosing ,Prospective Studies ,Medical prescription ,business ,Psychology ,Child ,media_common ,Drug Labeling - Abstract
Objectives To determine parental understanding of directions on common pediatric prescription pharmacy labels and to identify enablers and barriers that affect interpretation of these labels. Methods Prospective qualitative descriptive study (July to August 2020) of 20 parents in post-surgical wards at a single Australian tertiary pediatric center. Results Four key themes emerged through inductive analysis of the interview transcripts: 1) the addition of specific directions, such as administration with/without food and treatment course duration were perceived to be beneficial; 2) explicit phrasing of dosing intervals and times were more easily interpreted; 3) the use of simpler and common terminology enhanced understanding of the directions; and 4) presentation of multiple-step directions (e.g. tapering regimens) in a simplified and more organized manner was identified as an enabler and was thought to reduce confusion. Conclusion Differences in wording and presentation of pediatric prescription medication label directions led to variable interpretation by parents. Practise Implications Therefore, there is a need for guidelines to standardize the wording of prescription medication advice labels. Findings from this study can be used to achieve this goal. more...
- Published
- 2021
150. A Smartphone Intervention for People With Serious Mental Illness: Fully Remote Randomized Controlled Trial of CORE (Preprint)
- Author
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Dror Ben-Zeev, Ayesha Chander, Justin Tauscher, Benjamin Buck, Subigya Nepal, Andrew Campbell, and Guy Doron
- Abstract
BACKGROUND People with serious mental illness (SMI) have significant unmet mental health needs. Development and testing of digital interventions that can alleviate the suffering of people with SMI is a public health priority. OBJECTIVE The aim of this study is to conduct a fully remote randomized waitlist-controlled trial of CORE, a smartphone intervention that comprises daily exercises designed to promote reassessment of dysfunctional beliefs in multiple domains. METHODS Individuals were recruited via the web using Google and Facebook advertisements. Enrolled participants were randomized into either active intervention or waitlist control groups. Participants completed the Beck Depression Inventory-Second Edition (BDI-II), Generalized Anxiety Disorder-7 (GAD-7), Hamilton Program for Schizophrenia Voices, Green Paranoid Thought Scale, Recovery Assessment Scale (RAS), Rosenberg Self-Esteem Scale (RSES), Friendship Scale, and Sheehan Disability Scale (SDS) at baseline (T1), 30-day (T2), and 60-day (T3) assessment points. Participants in the active group used CORE from T1 to T2, and participants in the waitlist group used CORE from T2 to T3. Both groups completed usability and accessibility measures after they concluded their intervention periods. RESULTS Overall, 315 individuals from 45 states participated in this study. The sample comprised individuals with self-reported bipolar disorder (111/315, 35.2%), major depressive disorder (136/315, 43.2%), and schizophrenia or schizoaffective disorder (68/315, 21.6%) who displayed moderate to severe symptoms and disability levels at baseline. Participants rated CORE as highly usable and acceptable. Intent-to-treat analyses showed significant treatment×time interactions for the BDI-II (F1,313=13.38; P<.001), GAD-7 (F1,313=5.87; P=.01), RAS (F1,313=23.42; P<.001), RSES (F1,313=19.28; P<.001), and SDS (F1,313=10.73; P=.001). Large effects were observed for the BDI-II (d=0.58), RAS (d=0.61), and RSES (d=0.64); a moderate effect size was observed for the SDS (d=0.44), and a small effect size was observed for the GAD-7 (d=0.20). Similar changes in outcome measures were later observed in the waitlist control group participants following crossover after they received CORE (T2 to T3). Approximately 41.5% (64/154) of participants in the active group and 60.2% (97/161) of participants in the waitlist group were retained at T2, and 33.1% (51/154) of participants in the active group and 40.3% (65/161) of participants in the waitlist group were retained at T3. CONCLUSIONS We successfully recruited, screened, randomized, treated, and assessed a geographically dispersed sample of participants with SMI entirely via the web, demonstrating that fully remote clinical trials are feasible in this population; however, study retention remains challenging. CORE showed promise as a usable, acceptable, and effective tool for reducing the severity of psychiatric symptoms and disability while improving recovery and self-esteem. Rapid adoption and real-world dissemination of evidence-based mobile health interventions such as CORE are needed if we are to shorten the science-to-service gap and address the significant unmet mental health needs of people with SMI during the COVID-19 pandemic and beyond. CLINICALTRIAL ClinicalTrials.gov NCT04068467; https://clinicaltrials.gov/ct2/show/NCT04068467 more...
- Published
- 2021
- Full Text
- View/download PDF
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