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101. Early characterization of difficult-to-treat rheumatoid arthritis by suboptimal initial management: a multicentre cohort study

Author: Alessandro Giollo, Margherita Zen, Maddalena Larosa, Davide Astorri, Mariangela Salvato, Antonia Calligaro, Konstantinos Botsios, Cristina Bernardi, Gerolamo Bianchi, and Andrea Doria
Subjects: therapy, glucocorticoids, rheumatoid, treatment, delay, prednisolone, difficult-to-treat, MTX, DMARDs, methotrexate, refractory, arthritis, Rheumatology, D2T, biologics, Pharmacology (medical), steroids
Abstract: Objectives To demonstrate that unsuccessful treatment optimization in early disease is associated with difficult-to-treat RA (D2T-RA). Methods In this retrospective multicentre cohort study conducted from 09/2021–03/2022, we enrolled individuals fulfilling the 2010 ACR/EULAR RA criteria diagnosed 2000–2019. The outcome was D2T-RA by the EULAR definition. We used robust regression to examine the associations with delay, dose, duration of methotrexate and discontinuation of glucocorticoids. We tested through multinomial regression which factors were associated with persistent inflammatory refractory RA (PIRRA) or non-inflammatory refractory RA (NIRRA). Sensitivity analysis included a case-control study matching the year of diagnosis. Results We enrolled 48 D2T-RA patients and 145 non-D2T-RA controls. Methotrexate was started within 3 months in 16.7% of D2T-RA vs 33.1% of non-D2T-RA (P = 0.011). Adequate duration of methotrexate was obtained in significantly fewer D2T-RA patients (70.8% vs 85.5%). Glucocorticoids were continued beyond 6 months in a higher proportion of D2T-RA patients (70.8% vs 33.8%, P Conclusion Failure to start methotrexate within 3 months and not being off glucocorticoids within 6 months are early predictive features of D2T-RA.
Published: 2022
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102. Geographical heterogeneity of clinical and serological phenotypes of systemic sclerosis observed at tertiary referral centres. The experience of the Italian SIR-SPRING registry and review of the world literature

Author: Clodoveo Ferri a, Rossella De Angelis b, Dilia Giuggioli a, Gianluigi Bajocchi c, Lorenzo Dagna d, Giovanni Zanframundo e, Rosario Foti f, Fabio Cacciapaglia g, Giovanna Cuomo, Alarico Ariani i, Edoardo Rosato j, Serena Guiducci k, Francesco Girelli l, Valeria Riccieri m, Elisabetta Zanatta n, Silvia Bosello o, Ilaria Cavazzana p, Francesca Ingegnoli q, Maria De Santisr, Giuseppe Murdaca s, Giuseppina Abignano t, Nicoletta Romeo u, Alessandra Della Rossa v, Maurizio Caminiti w, Annamaria Iuliano x, Giovanni Ciano y, Lorenzo Beretta z, Gianluca Bagnato aa, Ennio Lubrano ab, Ilenia De Andres ac, Alessandro Giollo ad, Marta Saracco ae, Cecilia Agnes af, Federica Lumetti a, Amelia Spinella a, Luca Magnani c, Corrado Campochiaro d, Giacomo De Luca d, Veronica Codullo e, Elisa Visalli f, Francesco Masini h, Antonietta Gigante j, Silvia Bellando-Randone k, Greta Pellegrino m, Erika Pigatto ag, Maria Grazia Lazzaroni p, Franco Franceschini p, Elena Generali r, Gianna Mennillo t, Simone Barsotti v, Giuseppa Pagano Mariano w, Francesca Calabrese w, Federica Furini ah, Licia Vultaggio ah, Simone Parisi ai, Clara Lisa Peroni ai, Davide Rozza aj, Anna Zanetti aj, Greta Carrara aj, Giampiero Landolfi aj, Carlo Alberto Scir`e aj, Gerolamo Bianchi al, Enrico Fusaro ai, Gian Domenico Sebastiani x, Marcello Govoni ah, Salvatore D’Angelo t, Franco Cozzi ag, Andrea Doria n, Florenzo Iannone g, Carlo Salvarani c, Marco Matucci-Cerinic d, k, On behalf of SPRING-SIR (Systemic Sclerosis PRogression INvestiGation group of the Italian Society of Rheumatology), A, Clodoveo Ferri, B, Rossella De Angeli, A, Dilia Giuggioli, C, Gianluigi Bajocchi, D, Lorenzo Dagna, E, Giovanni Zanframundo, F, Rosario Foti, G, Fabio Cacciapaglia, Cuomo, Giovanna, I, Alarico Ariani, J, Edoardo Rosato, K, Serena Guiducci, L, Francesco Girelli, M, Valeria Riccieri, N, Elisabetta Zanatta, O, Silvia Bosello, P, Ilaria Cavazzana, Q, Francesca Ingegnoli, De Santisr, Maria, S, Giuseppe Murdaca, T, Giuseppina Abignano, U, Nicoletta Romeo, V, Alessandra Della Rossa, W, Maurizio Caminiti, X, Annamaria Iuliano, Y, Giovanni Ciano, Z, Lorenzo Beretta, Bagnato aa, Gianluca, Lubrano ab, Ennio, De Andres ac, Ilenia, Giollo ad, Alessandro, Saracco ae, Marta, Agnes af, Cecilia, A, Federica Lumetti, A, Amelia Spinella, C, Luca Magnani, D, Corrado Campochiaro, D, Giacomo De Luca, E, Veronica Codullo, F, Elisa Visalli, H, Francesco Masini, J, Antonietta Gigante, K, Silvia Bellando-Randone, M, Greta Pellegrino, Pigatto ag, Erika, P, Maria Grazia Lazzaroni, P, Franco Franceschini, R, Elena Generali, T, Gianna Mennillo, V, Simone Barsotti, W, Giuseppa Pagano Mariano, W, Francesca Calabrese, Furini ah, Federica, Vultaggio ah, Licia, Parisi ai, Simone, Lisa Peroni ai, Clara, Rozza aj, Davide, Zanetti aj, Anna, Carrara aj, Greta, Landolfi aj, Giampiero, Alberto Scir`e aj, Carlo, Ak, Bianchi al, Gerolamo, Fusaro ai, Enrico, X, Gian Domenico Sebastiani, Govoni ah, Marcello, T, Salvatore D’Angelo, Cozzi ag, Franco, N, Andrea Doria, G, Florenzo Iannone, C, Carlo Salvarani, D, Marco Matucci-Cerinic, K, and behalf of SPRING-SIR (Systemic Sclerosis PRogression INvestiGation group of the Italian Society of Rheumatology), On
Subjects: Systemic sclerosis Scleroderma Geographical areas Macro-areas Environmental Referral
Published: 2022

103. The Effectiveness of Laser Therapy for Hypertrophic Burn Scars in Pediatric Patients: A Prospective Investigation

Author: Jennifer Zuccaro, Charis Kelly, Manuela Perez, Andrea Doria, and Joel S Fish
Subjects: 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Rehabilitation, Emergency Medicine, 030208 emergency & critical care medicine, Surgery
Abstract: Laser therapy has become a valuable treatment option for hypertrophic burn scars. Improvements in scar symptoms have been achieved using the ablative fractional carbon dioxide laser as well as the pulsed dye laser. However, research regarding the use of laser therapy among pediatric patients remains limited. Thus, the aim of this study was to investigate the effectiveness of using laser therapy to improve hypertrophic burn scars in a pediatric population using a comprehensive scar assessment protocol. A pragmatic, single-center, prospective observational study was conducted at a tertiary pediatric hospital. Twenty participants with hypertrophic burn scars were included. Laser procedures were administered at approximately two month intervals and scars were evaluated at five time points over one year using the Vancouver Scar Scale, the Patient and Observer Scar Assessment Scale, conventional ultrasound, ultrasound elastography, and a multi-probe skin analysis device. Seventy-one laser procedures were performed with most participants receiving treatment with both the ablative fractional carbon dioxide laser and the pulsed dye laser at the same session (83%). From baseline to study completion, significant improvements in all scar measures were observed (p < .05). In particular, improvements in overall scarring and in specific scar properties including thickness, stiffness, and color were found (p < .05). To the best our knowledge, this is the most comprehensive study to date to evaluate the effect of laser treatment on hypertrophic burn scars in a pediatric population. Our findings suggest that laser therapy is a beneficial treatment for burn-injured children as evidenced by the improvements in subjective and objective scar assessment measures.
Published: 2021
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104. Novel Schemes for Compact FELs in the THz Region

Author: Andrea Doria, Gian Piero Gallerano, and Emilio Giovenale
Subjects: terahertz, free electron laser, energy recovery, Physics, QC1-999
Abstract: The rapid advance of terahertz technologies in terms of radiation generators, systems, and scientific or industrial applications has put a particular focus on compact sources with challenging performances in terms of generated power (peak and/or average), radiation time structure, and frequency band tunability. Free electron laser (FEL)-based sources are probably the best candidates to express such a versatility; there are a number of schemes that have been investigated over the years to generate coherent radiation from free electrons in the mm-wave and terahertz regions of the spectrum, covering a wide frequency range from approximately 100 GHz to 10 THz. This paper proposes novel schemes for exploring the limits in the performance of radio frequency-driven free-electron devices in terms of ultrashort pulse duration, wide bandwidth operation, and energy recovery for near continuous wave (CW) operation. The aim of the present work is to demonstrate the feasibility of an FEL achieving performance comparable to a conventional photoconductive THz source, which is commonly used for time-domain spectroscopy (TDS), in terms of bandwidth and pulse duration. We will also demonstrate that a THz FEL could be very powerful and flexible in terms of tailoring its spectral features.
Published: 2019
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105. Subclinical Myocardial Fibrosis in Systemic Lupus Erythematosus as Assessed by Pulse-Cancellation Echocardiography: A Pilot Study

Author: Alessandro Giollo, Giulia Vinco, Giovanni Cioffi, Francesca Frizzera, Anna Quinternetto, Corinna Bergamini, Marta Dal Porto, Giovanni Orsolini, Margherita Zen, Andrea Doria, Davide Gatti, Flavio Luciano Ribichini, Giovanni Targher, Maurizio Rossini, and Ombretta Viapiana
Subjects: cardiovascular, echocardiography, eSCAR, flares, glucocorticoids, lupus, myocardial, myocarditis, strain, ultrasound, General Medicine
Abstract: The aim of this study was to examine whether scar imaging echocardiography with ultrasound multi-pulse scheme (eSCAR) can detect subclinical myocardial involvement in systemic lupus erythematosus (SLE). We consecutively recruited SLE patients and controls matched for age, sex, and cardiovascular risk factors. Participants with cardiac symptoms or a prior history of heart disease were excluded. All participants underwent eSCAR and speckle tracking echocardiography (STE) with global longitudinal strain (GLS) assessment. SLE patients were assessed for disease activity and were followed up for 12 months. Myocardial scars by eSCAR were observed in 19% of SLE patients, almost exclusively localized at the inferoseptal myocardial segments, and in none of the controls. GLS was significantly lower in most myocardial segments of SLE patients compared with the controls, especially in the inferoseptal segments. eSCAR-positive SLE patients received a higher cumulative and current dose of prednisone, and had significantly higher levels of anti-dsDNA antibodies (p = 0.037). eSCAR-positive patients were at higher risk of having SLE flares over follow-up (hazard ratio: 4.91; 95% CI 1.43–16.83; p = 0.0001). We identified inferoseptal myocardial scars by eSCAR in about one-fifth of SLE patients. Subclinical myocardial involvement was associated with glucocorticoid use and anti-dsDNA antibodies.
Published: 2022
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106. Defining the targets in SLE management: insights and unmet gaps

Author: Margherita Zen, Mariele Gatto, and Andrea Doria
Subjects: Lupus Erythematosus, Rheumatology, Epidemiology, Systemic, Immunology, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, Glucocorticoids, General Biochemistry, Genetics and Molecular Biology
Published: 2022

107. Caveats and pitfalls in defining low disease activity in systemic lupus erythematosus

Author: Beatriz Samões, Margherita Zen, Joana Abelha-Aleixo, Mariele Gatto, and Andrea Doria
Subjects: Systemic lupus erythematosus, Remission, Immunology, Low disease activity, Quality of Life, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, Treat-to-target, Glucocorticoids, Severity of Illness Index
Abstract: The treat-to-target strategy has been recently suggested in the management of Systemic Lupus Erythematosus (SLE). Lupus Low Disease Activity State (LLDAS) and Definitions Of Remission In SLE (DORIS) remission were outlined as two concentric targets. The achievement of LLDAS was shown to be associated with lower frequency of SLE flare, decreased damage progression, better quality of life, and reduced mortality. In addition, LLDAS has successfully been tested in post-hoc analyses of a number of randomized controlled trials. However, it has been recently underlined that LLDAS includes a high proportion of patients in remission, raising the question if these endpoints are sufficiently distinct to consider their separation clinically relevant. Some studies suggest that the protective effect of LLDAS on damage might be due to the inclusion of patients who are in remission. Notably, clinical low disease activity (LDA) seems to be uncommon in SLE due to the relapsing-remitting pattern of the disease, in which low level of activity only occurs transiently. Moreover, since the domains included in LLDAS have several limitations, such as the use of a binomial disease activity index, the exclusion of some mild manifestations and the consideration of items subjected to variability (physician global assessment and glucocorticoids dose), not all patients in LDA are adequately represented by LLDAS.
Published: 2022

108. Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus:the PISCOS study

Author: Matteo Piga, Elisabetta Chessa, Eric F Morand, Manuel F Ugarte-Gil, Maria Tektonidou, Ronald van Vollenhoven, Michelle Petri, Laurent Arnaud, Simone Appenzeller, Cynthia Aranow, Anca Askanase, Tadej Avcin, Sang-Cheol Bae, George Bertsias, Eloisa Bonfa, Ernesto Cairoli, Mario H Cardiel, Ricard Cervera, François Chasset, Carlo Chizzolini, Ann E Clarke, Fabrizio Conti, Nathalie Costedoat-Chalumeau, László Czirják, Andrea Doria, Thomas Dörner, Gerard Espinosa, Rebecca Fischer-Betz, Mercedes Garcìa, Dafna D Gladman, Luis A González, Iva Gunnarsson, Laniyati Hamijoyo, John G Hanly, Sarfaraz A Hasni, Frédéric A Houssiau, Murat Inanç, Luís S Inês, David Isenberg, Soren Jacobsen, Yeong-Jian Jan Wu, Yuko Kaneko, Yasuhiro Katsumata, Chak S Lau, Alexandra C Legge, Karoline Lerang, Maarten Limper, Worawit Louthrenoo, Shue-Fen Luo, António Marinho, Loreto Massardo, Alexis Mathian, Marta Mosca, Mandana Nikpour, José M Pego-Reigosa, Christine A Peschken, Bernardo A Pons-Estel, Guillermo J Pons-Estel, Anisur Rahman, Simona Rednic, Camillo Ribi, Guillermo Ruiz-Irastorza, Emilia I Sato, Amit Saxena, Matthias Schneider, Gian Domenico Sebastiani, Vibeke Strand, Elisabet Svenungsson, Yoshiya Tanaka, Zoubida Tazi Mezalek, Michael L Tee, Angela Tincani, Zahi Touma, Anne Troldborg, Carlos Vasconcelos, Évelyne Vinet, Edward M Vital, Alexandre E Voskuyl, Anne Voss, Daniel Wallace, Michael Ward, and Leonid D Zamora
Subjects: DISEASE-ACTIVITY STATE, Rheumatology, ACTIVITY INDEX, Immunology, CAUCASIAN PATIENTS, SLE, Immunology and Allergy, FLARE, IMPACT TRACKER, REMISSION, DOUBLE-STRANDED DNA, MONOCENTRIC COHORT, ASSESSMENT PGA
Abstract: The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were rated, using a 0 (strongly disagree) to 10 (strongly agree) numerical rating scale. Statements with agreement of 75% or greater were selected and further validated by the expert panel. Consensus was reached on 27 statements, grouped in 14 recommendations, for the use of the PGA in SLE, design of the PGA scale, practical considerations for PGA scoring, and the relationship between PGA values and levels of disease activity. Among these recommendations, the expert panel agreed that the PGA should consist of a 0–3 visual analogue scale for measuring disease activity in patients with SLE in the preceding month. The PGA is intended to rate the overall disease activity, taking into account the severity of active manifestations and clinical laboratory results, but excluding organ damage, serology, and subjective findings unrelated to disease activity. The PGA scale ranges from “no disease activity” (0) to the “most severe disease activity” (3) and incorporates the values 1 and 2 as inner markers to categorise disease activity as mild (≥0·5 to 1), moderate (>1 and ≤2) and severe (>2 to 3). Only experienced physicians can rate the PGA, and it should be preferably scored by the same rater at each visit. The PISCOS results will allow for increased homogeneity and reliability of PGA ratings in routine clinical practice, definitions of remission and low disease activity, and future SLE trials.
Published: 2022
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109. Post-COVID-19 arthritis: a case report and literature review

Author: C. Piovella, V. Framba, Michela Gasparotto, Andrea Doria, and Luca Iaccarino
Subjects: Male, medicine.medical_specialty, Arthritis, Disease, medicine.disease_cause, Reactive arthritis, Rheumatology, Internal medicine, medicine, Humans, Intensive care medicine, Coronavirus, Oligoarthritis, SARS-CoV-2, business.industry, Mechanism (biology), COVID-19, General Medicine, Middle Aged, medicine.disease, Pneumonia, Case Based Review, SARS-CoV2, RNA, Viral, Molecular mimicry, business
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is the novel pathogen responsible for the coronavirus disease 19 (COVID-19) outbreak. Researchers and clinicians are exploring the pathogenetic mechanisms of the viral-induced damage and growing interest is focusing on the short-term and long-term immune-mediated consequences triggered by the infection. We will focus on post-SARS-CoV2 infection arthritis which may arise as a new pathological condition associated with COVID-19. In this article, we describe a case of acute oligoarthritis occurring 13 days after a SARS-CoV2 severe pneumonia in a middle-aged Caucasian man and we go over a brief review of the current available literature. We hypothesize that molecular mimicry might be the basic immunological mechanism responsible for the onset of COVID-19-related arthritis based on the current knowledge of SARS-CoV2 and on the known pathogenetic mechanism of viral-induced arthritis.
Published: 2021
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110. Le complexe antigène de carcinome à cellules squameuses-IgM (SCCA-IgM) est associé à la pneumopathie interstitielle diffuse dans la sclérodermie systémique

Author: Patrizia Pontisso, A. Martini, Alessandra Biasiolo, Francesco Benvenuti, Augusta Ortolan, Elena Scarpieri, Franco Cozzi, Andrea Doria, and Elisabetta Zanatta
Subjects: 030203 arthritis & rheumatology, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, 030212 general & internal medicine
Abstract: Resume Objectif La pneumopathie interstitielle diffuse (PID) est un facteur majeur de pronostic chez les patients atteints de sclerodermie systemique (ScS). L’antigene de carcinome a cellules squameuses (SCCA1) est un inhibiteur des proteases a serine qui joue un role essentiel dans l’inflammation et la fibrose. Le SCCA1 est surexprime dans le tissu pulmonaire des patients presentant une fibrose pulmonaire idiopathique et peut etre detecte dans le serum comme un complexe immun circulant lie a l’IgM (SCCA-IgM). Nous avons souhaite explorer l’association entre le SCCA-IgM et les caracteristiques cliniques des patients atteints de ScS. Methodes Quatre-vingt-dix-sept patients consecutifs atteints de ScS (selon les criteres ACR/EULAR) ont ete recrutes dans l’etude. Les variables cliniques et serologiques et les atteintes d’organe ont ete consignees. L’atteinte pulmonaire a ete exploree par tomodensitometrie haute resolution (TDM-HR) et par des tests de la fonction respiratoire. Les taux seriques de SCCA-IgM ont ete mesures par un test ELISA valide (Hepa-IC, Xeptagen, Venise, Italie). Nous avons defini le seuil des valeurs seriques de SCCA-IgM > 200 UA/mL, calcule comme la moyenne + 3 ecarts types chez 100 sujets en bonne sante. Resultats Quarante-et-un patients (42,3 %) presentaient une PID. Les taux de SCCA-IgM etaient significativement plus eleves chez les patients avec PID que chez les patients sans PID : 218 (80–402) contre 87,5 (59–150) UA/mL, p Conclusion Le SCCA-IgM est associe a la pneumopathie interstitielle diffuse chez les patients sclerodermiques et pourrait etre utilise dans l’evaluation de la PID associee a la ScS.
Published: 2020
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111. Pseudotumoral calcinosis in systemic sclerosis: Data from systematic literature review and case series from two referral centres

Author: Marie Desportes, Andrea Doria, Yannick Allanore, Huy Hoang Do, Antoine Feydy, Elisabetta Zanatta, and Jérôme Avouac
Subjects: medicine.medical_specialty, Referral, Shoulders, Population, Pseudotumoral, Wrist, Rheumatology, Calcinosis, Humans, Medicine, education, Referral and Consultation, Aged, Skin, education.field_of_study, Scleroderma, Systemic, Medical treatment, business.industry, Tumoral, Middle Aged, University hospital, medicine.disease, Dermatology, Radiography, Anesthesiology and Pain Medicine, Systematic review, medicine.anatomical_structure, Systemic sclerosis, Vascular Phenotype, business
Abstract: Objectives We aimed to clarify the definition, distribution, clinical association and outcomes of large calcinosis in patients with systemic sclerosis (SSc). Methods We conducted a systematic literature review (SLR) focusing on SSc-related large calcified masses. Upon updating the terminology and definition, all cases of “pseudotumoral” calcinosis seen at the Cochin and Padova University Hospitals were reviewed. Results The SLR yielded 30 SSc cases, with large calcified masses mainly defined as “tumoral” or “pseudotumoral”. Among the 629 SSc cases included in the Cochin and Padova cohorts, 19 (3%) living and 7 deceased patients were affected by pseudotumoral calcinosis; among these, the great majority had a severe vascular phenotype. The mean age in the whole population (56 cases) was 59 ± 11.4 years with a median disease duration at calcinosis onset of 7 (5–10) years. Twenty-five out of 56 patients (44.6%) had the diffuse cutaneous form of SSc. Anti-topisomerase I and anticentromere were found equally. Pseudotumoral calcinosis were commonly symmetrical and the size ranged from 2 to 15.5 cm. Most patients had multiple site involvement: 52% hand/wrist, 29% shoulders and elbows, 20% hips and 25% spinal calcinosis. Fistulization/ulceration and infections were reported in 32% and 23% of cases, respectively; nerve compression was found in 40% of spinal calcinosis and in one patient with limb calcinosis. There was no clear evidence of clinical and radiological improvement with any treatment. A partial improvement was seen in 7 patients that underwent surgery. Conclusion Pseudotumoral calcinosis may occur in about 3% of SSc patients, commonly symmetrical and in multiple sites without differences regarding the cutaneous subtypes but often in those with a severe vascular phenotype. Medical treatment seems ineffective, whereas a surgical approach may be considered.
Published: 2020
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112. Lupus nephritis: clinical presentations and outcomes in the 21st century

Author: Gabriella Moroni, Andrea Doria, Michela Gasparotto, Mariele Gatto, and Valentina Binda
Subjects: medicine.medical_specialty, 030232 urology & nephrology, Lupus nephritis, B cells, calcineurin inhibitors, classification, lupus nephritis, prognosis, renal biopsy, risk factors, Unmet needs, End stage renal disease, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Recurrence, Epidemiology, medicine, Humans, Pharmacology (medical), Intensive care medicine, AcademicSubjects/MED00360, Disease prognosis, 030203 arthritis & rheumatology, business.industry, Mortality rate, Remission Induction, Retrospective cohort study, medicine.disease, Precision medicine, Supplement Papers, Disease Progression, business
Abstract: Lupus nephritis (LN) is a frequent and severe manifestation of SLE. Along the decades, the epidemiology of LN and its clinical presentation have been changing. However, even though retrospective cohort studies report a decreased mortality rate and an improvement in the disease prognosis, the percentage of patients progressing into end stage renal disease (ESRD) keeps steady despite the improvements in therapeutic strategies. Current in-use medications have been available for decades now, yet over the years, regimens for optimizing their efficacy and minimizing toxicity have been developed. Therapeutic research is now moving towards the direction of precision medicine and several new drugs, targeting selectively different pathogenetic pathways, are currently under evaluation with promising results. In this review, we address the main changes and persistent unmet needs in LN management throughout the past decades, with a focus on prognosis and upcoming treatments.
Published: 2020
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113. Prevalence, outcome and management of patients with SLE and secondary antiphospholipid antibody syndrome after aPL seroconversion

Author: Francesca Saccon, Francesco Benvenuti, Margherita Zen, Maddalena Larosa, Luca Iaccarino, Mariele Gatto, Marta Loredo Martinez, and Andrea Doria
Subjects: Male, medicine.medical_specialty, antiphospholipid antibody syndrome, SLE, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, immune system diseases, Antiphospholipid syndrome, Internal medicine, Prevalence, medicine, Humans, Lupus Erythematosus, Systemic, Pharmacology (medical), Seroconversion, Simplified Acute Physiology Score, Thrombus, Retrospective Studies, oral anticoagulation, therapy withdrawal, 030203 arthritis & rheumatology, Lupus anticoagulant, business.industry, Anticoagulants, Thrombosis, Odds ratio, Middle Aged, Antiphospholipid Syndrome, medicine.disease, Discontinuation, Treatment Outcome, Antibodies, Antiphospholipid, Female, business
Abstract: Objective The withdrawal of oral anticoagulation (OAC) in patients with SLE and secondary aPL syndrome (SAPS) who become seronegative has not been clearly investigated to date. Our aim was to evaluate the prevalence of aPL seroconversion and the prognosis of SLE patients with SAPS who withdrew OAC after aPL negativization. Methods We retrospectively analysed data of all SLE patients (ACR criteria) with SAPS (Sydney criteria) prospectively followed-up in our clinic. aPL seroconversion was defined as negativization of lupus anticoagulant, aCL, and anti-β2glycoprotein-1 antibodies on two or more consecutive measurements, at least 12 weeks apart. OAC discontinuation was defined as the definitive withdrawal of all anticoagulants. Results Fifty-five out of 513 (10.7%) SLE patients had vascular SAPS. Sixteen patients (29.1%) became aPL seronegative during follow-up. Immunosuppressive therapy predicted aPL negativization (odds ratio 5.211, 95%CI 1.341, 20.243), whereas APS diagnosis prior to that of SLE (odds ratio 0.078, 95%CI 0.008, 0.799) and triple-positive profile (odds ratio 0.264, 95%CI 0.115, 0.609) were negative predictors of aPL negativization. OAC was discontinued in 13/55 patients (23.6%), after a median follow-up of 45 months (range 1–276) from aPL seroconversion. SLE-related modifiable risk factors for thrombosis were observed in 10/13 patients (77%) at the time of the thrombotic event. No thrombotic recurrences were observed during a mean follow-up time of 44 (19) months from OAC discontinuation. Conclusions Our results suggest that OAC can be safely discontinued in SLE patients who became persistently seronegative for aPL, at least when aPL-related thrombotic events occurred in presence of other thrombotic risk factors.
Published: 2020
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114. Nonimmune mechanisms in idiopathic inflammatory myopathies

Author: Marta Loredo Martinez, Anna Ghirardello, Sandra Zampieri, Chiara Franco, Andrea Doria, and Mariele Gatto
Subjects: 0301 basic medicine, Muscle Fibers, Skeletal, Inflammation, Neuromuscular junction, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Autophagy, medicine, Humans, 030203 arthritis & rheumatology, Denervation, Myositis, business.industry, Toll-Like Receptors, Endoplasmic Reticulum Stress, 030104 developmental biology, medicine.anatomical_structure, TLR3, Immunology, Unfolded protein response, medicine.symptom, Reactive Oxygen Species, business, Interferon type I, medicine.drug
Abstract: Purpose of review This review encompasses the main novelties regarding nonimmune mechanisms implicated in the pathogenesis of idiopathic inflammatory myopathies (IIM). Recent findings In recent years, growing data support a role for endoplasmic-reticulum (ER) stress as a propagator of muscular damage, together with the release of interferon type I and reactive oxygen species in hypoxemic muscle fibers. Other studies evaluating the relationship between autophagy and Toll-like receptors (TLRs) in IIM subtypes have shown increased TLR3 and TLR4 expression in fibers of IIM patients and colocalization with LC3, an autophagy marker, submitting autophagy as a likely player in IIM pathogenesis. Most novel evidences concern the potential role of denervation of the neuromuscular junction in IIM, possibly connected to hyperexpression of MHC-I, and trafficking of extracellular vesicles, which may represent a connection between nonimmune and immune-mediated mechanisms of muscle inflammation and damage. Summary Nonimmune mechanisms contribute to the pathogenesis of IIM, likely cooperating with immune-mediated inflammation. Consistent data were released for ER stress, autophagy, mitochondrial dysfunction and hypoxia; in addition to, neuromuscular denervation and extracellular vesicles have been proposed as thoughtful links between muscle inflammation, damage and atrophy. Further understanding of nonimmune abnormalities and potential reversible pathways is needed to improve the management of IIM.
Published: 2020
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115. Renal disorders in rheumatologic diseases: the spectrum is changing (Part 1: connective tissue diseases)

Author: Claudio Ponticelli, Gabriella Moroni, and Andrea Doria
Subjects: Nephrology, medicine.medical_specialty, 030232 urology & nephrology, Lupus nephritis, 030204 cardiovascular system & hematology, urologic and male genital diseases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Lupus Erythematosus, Systemic, Rapidly progressive glomerulonephritis, Connective Tissue Diseases, Scleroderma, Systemic, Systemic lupus erythematosus, business.industry, Acute kidney injury, Glomerulonephritis, Dermatomyositis, medicine.disease, Dermatology, Sjogren's Syndrome, Nephritis, Interstitial, business, Nephrotic syndrome
Abstract: The kidney is frequently involved by autoimmune rheumatic diseases. The renal manifestations may be variable, ranging from asymptomatic proteinuria and microscopic haematuria to nephrotic syndrome and rapidly progressive glomerulonephritis or vasculitis. In a number of cases the kidney involvement is related to the treatment of the original disease and may represent a major cause of morbidity and mortality. Thus, it is important for nephrologists and rheumatologists to remember that dysfunction of the kidney may be part of the primary systemic disorder or consequence of its pharmacotherapy. In the first part of this review we will analyse the kidney involvement in four autoimmune connective tissue diseases: systemic lupus erythematosus, Sjögren syndrome, polymyositis/dermatomyositis, and systemic sclerosis. Renal disease is common in lupus and is a main cause of morbidity and mortality. About 10% of patients with Sjögren syndrome may present interstitial nephritis or, more rarely, glomerulonephritis. Myoglobinuria and acute kidney injury is a frequent complication of polymyositis. Renal disease is one of the most serious complications of systemic sclerosis and may present with a dramatic renal crisis, characterized by malignant hypertension, oligo-anuria, and microangiopathic thrombocytopenic anaemia.
Published: 2020
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116. The amount of cytokine-release defines different shades of Sars-Cov2 infection

Author: Paolo Sfriso, Mara Felicetti, Sara Bindoli, and Andrea Doria
Subjects: 0301 basic medicine, Secondary Hemophagocytic Lymphohistiocytosis, medicine.medical_treatment, Acute Lung Injury, Pneumonia, Viral, Disease, medicine.disease_cause, Lymphohistiocytosis, Hemophagocytic, General Biochemistry, Genetics and Molecular Biology, Virus, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Immune system, Lymphopenia, Humans, Medicine, HLH/MAS, Pandemics, COVID-19, CRS, SARS-CoV2, cytokines, Coronavirus, Respiratory Distress Syndrome, SARS-CoV-2, business.industry, medicine.disease, Phenotype, 030104 developmental biology, Cytokine, 030220 oncology & carcinogenesis, Immunology, Minireview, Coronavirus Infections, Cytokine Release Syndrome, business, Cytokine storm
Abstract: The recent outbreak of coronavirus disease (COVID 19), spreading from China all around the world in early 2020, has led scientists to investigate the immuno-mediated mechanisms underlying the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) infection. Depending on the amount of cytokines released as the result of the immunological activation induced by SARS-CoV2, three major clinical phenotypes can be identified: “mild”,symbolized as a “drizzle” of cytokines, severe as a “storm”, and critical as a “hurricane”. In patients with mild symptoms, the release of pro-inflammatory cytokines is balanced to obtain a defense response against the virus which is often self-limiting and overcomes without tissue damage. In severe phenotype, resembling a “cytokine-release syndrome”, SARS-CoV2 causes the lysis of the immune-mediators leading to a cytokine storm able to induce lung epithelium damage and acute respiratory distress syndrome. In critical patients, the immune response may become uncontrolled, thus the cytokine burst resembles a form of secondary hemophagocytic lymphohistiocytosis which may result in a multi organ failure. In addition to the standard of care, an immune-modulatory therapy tailored to each one of the different phenotypes should be used in order to prevent or reduce the release of cytokines responsible for organ damage and disease progression.
Published: 2020
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117. Biologic therapy in relapsing polychondritis: navigating between options

Author: Roberto Padoan, Debora Campaniello, Luca Iorio, Andrea Doria, and Franco Schiavon
Subjects: Pharmacology, Biological Products, anti-TNFα, Tumor Necrosis Factor-alpha, Clinical Biochemistry, Abatacept, Biological Therapy, tocilizumab, Biological Factors, Interleukin 1 Receptor Antagonist Protein, anakinra, biologic therapy, biological agents, infliximab, relapsing polychondritis, rituximab, Drug Discovery, Humans, Polychondritis, Relapsing, Rituximab, Glucocorticoids, Immunosuppressive Agents
Abstract: Relapsing polychondritis (RP) is a rare systemic inflammatory disease of unknown etiology, primarily affecting cartilaginous tissue and proteoglycan-rich structures. Clinical manifestations vary from mild symptoms to occasional organ or life-threatening complications. Treatment can be challenging and is mostly based on experience or case reports/series.There is growing literature investigating the role of biologics in the management of RP. TNFα antagonists, abatacept, tocilizumab, rituximab, anakinra and tofacitinib have been prescribed in several RP patients, mainly as second-line treatment, after conventional immunosuppressive agents' failure.Glucocorticoids represent the gold standard treatment of RP. Conventional immunosuppressants should be administered in refractory patients or when a glucocorticoid-sparing effect is needed. Biologic therapy should be used after failure of conventional treatments or in severe manifestations. TNFα inhibitors are the most prescribed biologic agent, with partial or complete response in several cases, but loss of efficacy may occur over time. Infliximab and adalimumab should be preferred among TNFα antagonists. Abatacept and tocilizumab proved to be effective as second-line biologic agents, but infections are reported with the former. Data on anakinra and rituximab are controversial, therefore they are not recommended as first-line biologic drugs. The use of JAK inhibitors is still anecdotal.
Published: 2022

118. Early and Late Response and Glucocorticoid-Sparing Effect of Belimumab in Patients with Systemic Lupus Erythematosus with Joint and Skin Manifestations: Results from the Belimumab in Real Life Setting Study—Joint and Skin (BeRLiSS-JS)

Author: Margherita Zen, Mariele Gatto, Roberto Depascale, Francesca Regola, Micaela Fredi, Laura Andreoli, Franco Franceschini, Maria Letizia Urban, Giacomo Emmi, Fulvia Ceccarelli, Fabrizio Conti, Alessandra Bortoluzzi, Marcello Govoni, Chiara Tani, Marta Mosca, Tania Ubiali, Maria Gerosa, Enrica P. Bozzolo, Valentina Canti, Paolo Cardinaletti, Armando Gabrielli, Giacomo Tanti, Elisa Gremese, Ginevra De Marchi, Salvatore De Vita, Serena Fasano, Francesco Ciccia, Giulia Pazzola, Carlo Salvarani, Simone Negrini, Andrea Di Matteo, Rossella De Angelis, Giovanni Orsolini, Maurizio Rossini, Paola Faggioli, Antonella Laria, Matteo Piga, Alberto Cauli, Salvatore Scarpato, Francesca Wanda Rossi, Amato De Paulis, Enrico Brunetta, Angela Ceribelli, Carlo Selmi, Marcella Prete, Vito Racanelli, Angelo Vacca, Elena Bartoloni, Roberto Gerli, Elisabetta Zanatta, Maddalena Larosa, Francesca Saccon, Andrea Doria, Luca Iaccarino, Zen, Margherita, Gatto, Mariele, Depascale, Roberto, Regola, Francesca, Fredi, Micaela, Andreoli, Laura, Franceschini, Franco, Letizia Urban, Maria, Emmi, Giacomo, Ceccarelli, Fulvia, Conti, Fabrizio, Bortoluzzi, Alessandra, Govoni, Marcello, Tani, Chiara, Mosca, Marta, Ubiali, Tania, Gerosa, Maria, Bozzolo, Enrica P., Canti, Valentina, Cardinaletti, Paolo, Gabrielli, Armando, Tanti, Giacomo, Gremese, Elisa, De Marchi, Ginevra, De Vita, Salvatore, Fasano, Serena, Ciccia, Francesco, Pazzola, Giulia, Salvarani, Carlo, Negrini, Simone, Di Matteo, Andrea, DE ANGELIS, Rossella, Orsolini, Giovanni, Rossini, Maurizio, Faggioli, Paola, Laria, Antonella, Piga, Matteo, Cauli, Alberto, Scarpato, Salvatore, Wanda Rossi, Francesca, De Paulis, Amato, Brunetta, Enrico, Ceribelli, Angela, Selmi, Carlo, Prete, Marcella, Racanelli, Vito, Vacca, Angelo, Bartoloni, Elena, Gerli, Roberto, Zanatta, Elisabetta, Larosa, Maddalena, Saccon, Francesca, Doria, Andrea, and Iaccarino, Luca
Subjects: disease activity score (DAS)-28, low disease activity, remission, systemic lupus erythematosus, belimumab, Cutaneous LE Area and Severity Index (CLASI), Medicine (miscellaneous)
Abstract: Aim. To assess the efficacy of belimumab in joint and skin manifestations in a nationwide cohort of patients with SLE. Methods. All patients with skin and joint involvement enrolled in the BeRLiSS cohort were considered. Belimumab (intravenous, 10 mg/kg) effectiveness in joint and skin manifestations was assessed by DAS28 and CLASI, respectively. Attainment and predictors of DAS28 remission (
Published: 2023
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119. Compact, High-Power Electron Beam Based Terahertz Sources.

Author: Sandra G. Biedron, John W. Lewellen, Stephen Val Milton, Nachappa Gopalsami, John F. Schneider, Laura Skubal, Yuelin Li, Mathew Virgo, Gian Piero Gallerano, Andrea Doria, Emilio Giovenale, Giovanni Messina, and Ivan Panov Spassovsky
Published: 2007
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120. Hyperinflammation after anti-SARS-CoV-2 mRNA/DNA vaccines successfully treated with anakinra: Case series and literature review

Author: Sara Bindoli, Alessandro Giollo, Paola Galozzi, Andrea Doria, and Paolo Sfriso
Subjects: Inflammation, Male, COVID-19 Vaccines, COVID-19, Hyperinflammation, vaccines, Middle Aged, General Biochemistry, Genetics and Molecular Biology, adult-onset-Still’s disease, anakinra, interleukin-1, macrophage activation syndrome, Interleukin 1 Receptor Antagonist Protein, ChAdOx1 nCoV-19, Vaccines, DNA, Humans, Female, Minireview, mRNA Vaccines, Still's Disease, Adult-Onset, BNT162 Vaccine, Interleukin-1
Abstract: The current SARS-CoV-2 pandemic diffused worldwide has encouraged the rapid development of vaccines to counter the spread of the virus. At present in Italy, 75.01% of the population completed the vaccination course (AIFA.gov.it) and very few adverse events have been recorded by now. Side-effects related to a theoretical over-reaction of the immune system in response to vaccines administration have been described, and the possibility that an autoimmune or a hyperinflammatory condition may occur was recently observed. Herein, we report four cases of hyperinflammatory syndrome with features indicative of Adult-onset Still’s disease (AOSD) and macrophage activation syndrome (MAS), occurred after anti-SARS-CoV-2 vaccine injection and seen at our Unit between March and May 2021. Since interleukin (IL)-1 is one of the pivotal cytokines involved in AOSD pathogenesis, the inhibition of IL-1 is crucial in ameliorating the clinical symptoms of those patients. Moreover, it has been highlighted the central role of IL-1 as a hallmark of the hyperinflammatory status elicited by SARS-CoV-2 infection. In this case series, we successfully employed the IL-1 receptor antagonist anakinra to curb the cytokine release likely unleashed by the vaccine stimulation in potentially predisposed subjects. We also made a literature search to detect other patients with hyperinflammation temporally related to vaccines injection who benefited from IL-1 inhibition, while other AOSD/MAS-like described syndromes improved with other immunomodulatory strategies.
Published: 2022

121. Thoracic involvement in systemic autoimmune rheumatic diseases: pathogenesis and management

Author: Elena De Zorzi, Paolo Spagnolo, Elisabetta Cocconcelli, Elisabetta Balestro, Luca Iaccarino, Mariele Gatto, Francesco Benvenuti, Nicol Bernardinello, Andrea Doria, Toby M. Maher, Elisabetta Zanatta, and British Lung Foundation
Subjects: PULMONARY ARTERIAL-HYPERTENSION, Allergy, Immunology, Interstitial lung disease, INTERSTITIAL LUNG-DISEASE, Pulmonary arterial hypertension, Autoimmune Diseases, Arthritis, Rheumatoid, Autoimmune rheumatic disorders, DOUBLE-BLIND, OBLITERANS ORGANIZING PNEUMONIA, Rheumatic Diseases, LUPUS-ERYTHEMATOSUS, Humans, Immunology and Allergy, IMMUNOSUPPRESSIVE THERAPY, Pleuritis, Airways disease, Connective tissue diseases, MYCOPHENOLATE-MOFETIL, Respiratory Distress Syndrome, Scleroderma, Systemic, Science & Technology, RESPIRATORY MANIFESTATIONS, General Medicine, 1107 Immunology, CONNECTIVE-TISSUE-DISEASE, PLEURAL INVOLVEMENT, Lung Diseases, Interstitial, Life Sciences & Biomedicine
Abstract: Thoracic involvement is one of the main determinants of morbidity and mortality in patients with autoimmune rheumatic diseases (ARDs), with different prevalence and manifestations according to the underlying disease. Interstitial lung disease (ILD) is the most common pulmonary complication, particularly in patients with systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIMs) and rheumatoid arthritis (RA). Other thoracic manifestations include pulmonary arterial hypertension (PAH), mostly in patients with SSc, airway disease, mainly in RA, and pleural involvement, which is common in systemic lupus erythematosus and RA, but rare in other ARDs.In this review, we summarize and critically discuss the current knowledge on thoracic involvement in ARDs, with emphasis on disease pathogenesis and management. Immunosuppression is the mainstay of therapy, particularly for ARDs-ILD, but it should be reserved to patients with clinically significant disease or at risk of progressive disease. Therefore, a thorough, multidisciplinary assessment to determine disease activity and degree of impairment is required to optimize patient management. Nevertheless, the management of thoracic involvement—particularly ILD—is challenging due to the heterogeneity of disease pathogenesis, the variety of patterns of interstitial pneumonia and the paucity of randomized controlled clinical trials of pharmacological intervention. Further studies are needed to better understand the pathogenesis of these conditions, which in turn is instrumental to the development of more efficacious therapies.
Published: 2022

122. Progress in Biological Therapies for Adult-Onset Still's Disease

Author: Paola Galozzi, Sara Bindoli, Andrea Doria, and Paolo Sfriso
Subjects: small molecules, Oncology, Rheumatology, Gastroenterology, new treatment, Immunology and Allergy, AOSD, IL-1 inhibitors, Pharmacology (medical), biologics, IL-6 inhibitors
Abstract: Adult-onset Still's disease (AOSD) is a rare multifactorial autoinflammatory disorder of unknown etiology, characterized by an excessive release of cytokines triggered by dysregulated inflammation and articular and systemic manifestations. The clinical spectrum of AOSD ranges from self-limiting forms with mild symptoms to life-threatening cases and presents clinical and biological similarities with the juvenile form (sJIA). Nowadays, the advances in biologic agents no longer limit the treatment to NSAIDs, glucocorticoids, or conventional synthetic DMARDs. The blockade of IL-1 and IL-6 is effective in the treatment of systemic and articular inflammation of AOSD patients; however, novel compounds with different properties and targets are now available and others are being studied. In this review, starting from the pathogenesis of AOSD, we summarized the current and emerging biological therapies, possible effective agents for achieving AOSD control and remission.
Published: 2022

123. Health-related quality of life in patients with mixed connective tissue disease: a comparison with matched systemic sclerosis patients

Author: Imane, Abouyahya, Sophie I E, Liem, Zahir, Amoura, João Eurico, Fonseca, Benjamin, Chaigne, Maurizio, Cutolo, Andrea, Doria, Rebecca, Fischer-Betz, Vera, Guimaraes, Thomas W J, Huizinga, Jacob M, van Laar, Thierry, Martin, Marco, Matucci-Cerinic, Carlomaurizio, Montecucco, Matthias, Schneider, Vanessa, Smith, Ulf, Müller-Ladner, and Jeska K, de Vries-Bouwstra
Subjects: Adult, Lung Diseases, Scleroderma, Systemic, systemic sclerosis, Humans, Prospective Studies, Quality of Life, Lung Diseases, Interstitial, Mixed Connective Tissue Disease, Systemic, Immunology, Scleroderma, Rheumatology, Immunology and Allergy, Interstitial
Abstract: Objective. Health-Related Quality of Life (HRQoL) in adult patients with mixed connective tissue disease (MCTD) has not been described so far. Therefore, we performed an explorative study to evaluate HRQoL in MCTD patients.Methods. MCTD patients fulfilling the Kahn criteria and participating in the prospective follow-up cohort for MCTD of the Leiden University Medical Center were included; and matched to systemic sclerosis (SSc) patients based on age, sex and disease duration. Data on disease characteristics and HRQoL (SF36 and EQ-5D) were collected annually. HRQoL was compared between MCTD and SSc patients at baseline. Factors associated with HRQoL in MCTD were identified using linear regression and change in HRQoL over 3 years using linear mixed models.Results. Thirty-four MCTD patients (121 visits) and 102 SSc patients (424 visits) were included. At baseline, MCTD patients presented with interstitial lung disease, cardiac involvement, synovitis and myositis more frequently compared to SSc patients, while use of immunosuppressive medication was less frequent. In both groups, mean SF36 scores were lower than in the general Dutch population. The SF36 subscore "general health perception" was impacted most in both groups (MCTD: 38.5 [SD:7.0], SSc: 39.9 [SD:8.9]). During follow-up, SF36 scores improved in MCTD patients, while EQ5DNL remained stable. No specific characteristics were identified that associated with baseline HRQoL or change in HRQol over time.Conclusion. Like in SSc, HRQoL in MCTD is significantly impaired, especially the general health perception of patients. Evaluation in larger prospective cohorts is needed to identify characteristics that impact HRQol most.
Published: 2022

124. Geographical heterogeneity of clinical and serological phenotypes of systemic sclerosis observed at tertiary referral centres. the experience of the Italian SIR-SPRING registry and review of the world literature

Author: Clodoveo Ferri, Rossella De Angelis, Dilia Giuggioli, Gianluigi Bajocchi, Lorenzo Dagna, Giovanni Zanframundo, Rosario Foti, Fabio Cacciapaglia, Giovanna Cuomo, Alarico Ariani, Edoardo Rosato, Serena Guiducci, Francesco Girelli, Valeria Riccieri, Elisabetta Zanatta, Silvia Bosello, Ilaria Cavazzana, Francesca Ingegnoli, Maria De Santis, Giuseppe Murdaca, Giuseppina Abignano, Nicoletta Romeo, Alessandra Della Rossa, Maurizio Caminiti, Annamaria Iuliano, Giovanni Ciano, Lorenzo Beretta, Gianluca Bagnato, Ennio Lubrano, Ilenia De Andres, Alessandro Giollo, Marta Saracco, Cecilia Agnes, Federica Lumetti, Amelia Spinella, Luca Magnani, Corrado Campochiaro, Giacomo De Luca, Veronica Codullo, Elisa Visalli, Francesco Masini, Antonietta Gigante, Silvia Bellando-Randone, Greta Pellegrino, Erika Pigatto, Maria Grazia Lazzaroni, Franco Franceschini, Elena Generali, Gianna Mennillo, Simone Barsotti, Giuseppa Pagano Mariano, Francesca Calabrese, Federica Furini, Licia Vultaggio, Simone Parisi, Clara Lisa Peroni, Davide Rozza, Anna Zanetti, Greta Carrara, Giampiero Landolfi, Carlo Alberto Scirè, Gerolamo Bianchi, Enrico Fusaro, Gian Domenico Sebastiani, Marcello Govoni, Salvatore D'Angelo, Franco Cozzi, Andrea Doria, Florenzo Iannone, Carlo Salvarani, Marco Matucci-Cerinic, Ferri, C, De Angelis, R, Giuggioli, D, Bajocchi, G, Dagna, L, Zanframundo, G, Foti, R, Cacciapaglia, F, Cuomo, G, Ariani, A, Rosato, E, Guiducci, S, Girelli, F, Riccieri, V, Zanatta, E, Bosello, S, Cavazzana, I, Ingegnoli, F, De Santis, M, Murdaca, G, Abignano, G, Romeo, N, Della Rossa, A, Caminiti, M, Iuliano, A, Ciano, G, Beretta, L, Bagnato, G, Lubrano, E, De Andres, I, Giollo, A, Saracco, M, Agnes, C, Lumetti, F, Spinella, A, Magnani, L, Campochiaro, C, De Luca, G, Codullo, V, Visalli, E, Masini, F, Gigante, A, Bellando-Randone, S, Pellegrino, G, Pigatto, E, Lazzaroni, M, Franceschini, F, Generali, E, Mennillo, G, Barsotti, S, Mariano, G, Calabrese, F, Furini, F, Vultaggio, L, Parisi, S, Peroni, C, Rozza, D, Zanetti, A, Carrara, G, Landolfi, G, Scire, C, Bianchi, G, Fusaro, E, Sebastiani, G, Govoni, M, D'Angelo, S, Cozzi, F, Doria, A, Iannone, F, Salvarani, C, and Matucci-Cerinic, M
Subjects: Settore MED/16 - REUMATOLOGIA, systemic sclerosis, Macro-areas, Immunology, Geographical areas, macro-areas, Antibodies, environmental, Environmental, Scleroderma, Tertiary Care Centers, Systemic sclerosi, Rheumatology, Antinuclear, Humans, Immunology and Allergy, scleroderma, Registries, Keywords: Environmental, Referral, Systemic sclerosis, Geographical area, Scleroderma, Systemic, geographical areas, Systemic, referral, Phenotype, Italy, Antibodies, Antinuclear, Macro-area
Abstract: Introduction: Systemic sclerosis (SSc) is characterized by a complex etiopathogenesis encompassing both host genetic and environmental -infectious/toxic- factors responsible for altered fibrogenesis and diffuse microangiopathy. A wide spectrum of clinical phenotypes may be observed in patients' populations from different geographical areas. We investigated the prevalence of specific clinical and serological phenotypes in patients with definite SSc enrolled at tertiary referral centres in different Italian geographical macro-areas. The observed findings were compared with those reported in the world literature. Materials and methods: The clinical features of 1538 patients (161 M, 10.5%; mean age 59.8 ± 26.9 yrs.; mean disease duration 8.9 ± 7.7 yrs) with definite SSc recruited in 38 tertiary referral centres of the SPRING (Systemic sclerosis Progression INvestiGation Group) registry promoted by Italian Society of Rheumatology (SIR) were obtained and clustered according to Italian geographical macroareas. Results: Patients living in Southern Italy were characterized by more severe clinical and/or serological SSc phenotypes compared to those in Northern and Central Italy; namely, they show increased percentages of diffuse cutaneous SSc, digital ulcers, sicca syndrome, muscle involvement, arthritis, cardiopulmonary symptoms, interstitial lung involvement at HRCT, as well increased prevalence of serum anti-Scl70 autoantibodies. In the same SSc population immunusppressive drugs were frequently employed. The review of the literature underlined the geographical heterogeneity of SSc phenotypes, even if the observed findings are scarcely comparable due to the variability of methodological approaches. Conclusion: The phenotypical differences among SSc patients' subgroups from Italian macro-areas might be correlated to genetic/environmental co-factors, and possibly to a not equally distributed national network of information and healthcare facilities.
Published: 2022

125. The added value of a European Reference Network on rare and complex connective tissue and musculoskeletal diseases: insights after the first 5 years of the ERN ReCONNET

Author: Rosaria Talarico, Silvia Aguilera, Tobias Alexander, Zahir Amoura, Janette Andersen, Laurent Arnaud, Tadej Avcin, Sara Marsal Barril, Lorenzo Beretta, Stefano Bombardieri, Alessandra Bortoluzzi, Coralie Bouillot, Inita Bulina, Gerd R. Burmester, Sara Cannizzo, Lorenzo Cavagna, Benjamin Chaigne, Alain Cornet, Paolo Corti, Nathalie Costedoat-Chalumeau, Zane Dāvidsone, Andrea Doria, Carol Fenech, Alessandro Ferraris, Rebecca Fischer-Betz, João Eurico Fonseca, Charissa Frank, Andrea Gaglioti, Ilaria Galetti, Vera Guimarães, Eric Hachulla, Monica Holmner, Frederic Houssiau, Luca Iaccarino, Søren Jacobsen, Maarten Limper, Fransiska Malfait, Xavier Mariette, Diana Marinello, Thierry Martin, Lisa Matthews, Marco Matucci-Cerinic, Alain Meyer, Jasminka Milas-Ahić, Pia Moinzadeh, Carlomaurizio Montecucco, Luc Mouthon, Ulf Müller-Ladner, György Nagy, Eunice Patarata, Margarita Pileckyte, Chris Pruunsild, Simona Rednic, Vasco C. Romão, Matthias Schneider, Carlo Alberto Scirè, Vanessa Smith, Alberto Sulli, Farah Tamirou, Chiara Tani, Domenica Taruscio, Anna V. Taulaigo, Angela Tincani, Simone Ticciati, Giuseppe Turchetti, P. Martin van Hagen, Jacob M. van Laar, Ana Viera, Jeska K. de Vries-Bouwstra, Johannes Zschocke, Maurizio Cutolo, Marta Mosca, Talarico, R, Aguilera, S, Alexander, T, Amoura, Z, Andersen, J, Arnaud, L, Avcin, T, Marsal Barril, S, Beretta, L, Bombardieri, S, Bortoluzzi, A, Bouillot, C, Bulina, I, Burmester, G, Cannizzo, S, Cavagna, L, Chaigne, B, Cornet, A, Corti, P, Costedoat-Chalumeau, N, Davidsone, Z, Doria, A, Fenech, C, Ferraris, A, Fischer-Betz, R, Fonseca, J, Frank, C, Gaglioti, A, Galetti, I, Guimaraes, V, Hachulla, E, Holmner, M, Houssiau, F, Iaccarino, L, Jacobsen, S, Limper, M, Malfait, F, Mariette, X, Marinello, D, Martin, T, Matthews, L, Matucci-Cerinic, M, Meyer, A, Milas-Ahic, J, Moinzadeh, P, Montecucco, C, Mouthon, L, Muller-Ladner, U, Nagy, G, Patarata, E, Pileckyte, M, Pruunsild, C, Rednic, S, Romao, V, Schneider, M, Scire, C, Smith, V, Sulli, A, Tamirou, F, Tani, C, Taruscio, D, Taulaigo, A, Tincani, A, Ticciati, S, Turchetti, G, van Hagen, P, van Laar, J, Vieira, A, de Vries-Bouwstra, J, Zschocke, J, Cutolo, M, Mosca, M, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, and UCL - (SLuc) Service de rhumatologie
Subjects: rare and complex diseases, Health Personnel, rare and complex disease, Immunology, patient care, European Reference Network, rheumatic and musculoskeletal diseases, rheumatic and musculoskeletal disease, Europe, European Reference Networks, Rare Diseases, Rheumatology, Connective Tissue, connective tissue disease, Immunology and Allergy, Humans, Musculoskeletal Diseases, connective tissue diseases, European Commission
Abstract: In order to address the main challenges related to the rare diseases (RDs) the European Commission launched the European Reference Networks (ERNs), virtual networks involving healthcare providers (HCPs) across Europe. The mission of the ERNs is to tackle low prevalence and RDs that require highly specialised treatment and a concentration of knowledge and resources. In fact, ERNs offer the potential to give patients and healthcare professionals across the EU access to the best expertise and timely exchange of lifesaving knowledge, trying to make the knowledge travelling more than patients. For this reason, ERNs were established as concrete European infrastructures, and this is particularly crucial in the framework of rare and complex diseases in which no country alone has the whole knowledge and capacity to treat all types of patients. It has been five years since their kick-off launch in Vilnius in 2017. The 24 ERNs have been intensively working on different transversal areas, including patient management, education, clinical practice guidelines, patients' care pathways and many other fundamental topics. The present work is therefore aimed not only at reporting a summary of the main activities and milestones reached so far, but also at celebrating the first 5 years of the ERN on Rare and Complex Connective Tissue and Musculo-skeletal Diseases (ReCONNET), in which the members of the network built together one of the 24 infrastructures that are hopefully going to change the scenario of rare diseases across the EU.
Published: 2022
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126. Impact of low-dose acetylsalicylic acid on pregnancy outcome in systemic lupus erythematosus: results from a multicentre study

Author: Chiara Tani, Dina Zucchi, Isabell Haase, Maria Gerosa, Maddalena Larosa, Lorenzo Cavagna, Alessandra Bortoluzzi, Francesca Crisafulli, Johanna Mucke, Francesca A L Strigini, Laura Baglietto, Marco Fornili, Francesca Monacci, Elena Elefante, Roberta Erra, Elisa Bellis, Melissa Padovan, Laura Andreoli, Lavinia Agra Coletto, Giovanni Zanframundo, Marcello Govoni, Luca Iaccarino, Angela Tincani, Andrea Doria, Rebecca Fischer-Betz, and Marta Mosca
Subjects: Aspirin, Lupus Erythematosus, lupus erythematosus, systemic, outcome assessment, health care, therapeutics, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome, Retrospective Studies, Lupus Erythematosus, Systemic, Pre-Eclampsia, Systemic, Infant, General Medicine, Newborn, health care, Rheumatology, outcome assessment
Abstract: ObjectiveIt is still a matter of debate whether low-dose acetylsalicylic acid (LDASA) should be prescribed to all patients with SLE during pregnancy. This study aimed at investigating the impact of LDASA on pregnancy outcomes in patients with SLE without history of renal involvement and without antiphospholipid antibodies (aPL).MethodsThis is a retrospective analysis of prospectively monitored pregnancies at seven rheumatology centres. Previous/current renal involvement and aPL positivity were the exclusion criteria. Adverse pregnancy outcome (APO) is the composite outcome of the study and included proteinuric pre-eclampsia, preterm delivery Results216 pregnancies in 187 patients were included; 82 pregnancies (38.0%) were exposed to LDASA treatment. No differences in terms of age at conception, disease duration, clinical manifestations, comorbidities and disease flare during pregnancy were observed between patients taking LDASA and those who did not take LDASA during pregnancy. APO was observed in 65 cases (30.1%), including 13 cases (6.1%) of pre-eclampsia. The incidence of all complications was similar in the two groups. However, it is interesting to note that pre-eclampsia had lower frequency in patients taking LDASA versus those not taking LDASA (2.4% vs 8.3%, p=0.14).ConclusionsIn pregnant patients with SLE without renal involvement and were aPL-negative, there is a low risk of severe obstetric complications, such as early pre-eclampsia. LDASA treatment does not provide a statistically significant advantage over these complications. However, a careful individual risk–benefit balance is warranted.
Published: 2022

127. Sjögren's syndrome and other rare and complex connective tissue diseases: an intriguing liaison

Author: Chiara Baldini, Laurent Arnaud, Tadej Avčin, Lorenzo Beretta, Chiara Bellocchi, Coralie Bouillot, Gerd-Rüdiger Burmester, Lorenzo Cavagna, Maurizio Cutolo, Jeska K. de Vries-Bouwstra, Andrea Doria, Francesco Ferro, João Eurico Fonseca, Silvia Fonzetti, Giovanni Fulvio, Ilaria Galetti, Jacques-Eric Gottenberg, Eric Hachulla, Thomas Krieg, Gaetano La Rocca, Thierry Martin, Marco Matucci-Cerinic, Pia Moinzadeh, Carlomaurizio Montecucco, Marta Mosca, Luc Mouthon, Ulf Müller-Ladner, Simona Rednic, Vanessa Smith, Rosaria Talarico, Jacob M. van Laar, Ana Vieira, Vasco C. Romão, and Xavier Mariette
Subjects: Scleroderma, Systemic, Sjogren's Syndrome, Rheumatology, Immunology, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, Connective Tissue Diseases, Autoimmune Diseases
Abstract: Sjögren's syndrome (SS) is a systemic autoimmune disease that frequently occurs concomitantly with other systemic connective tissue disorders, including rare and complex diseases such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). The presence of SS influences the clinical expression of the other autoimmune diseases, thus offering the unique opportunity to explore the similarities in genetic signatures, as well as common environmental and biologic factors modulating the expression of disease phenotypes. In this review, we will specifically discuss the possibility of defining "SS/SLE" and "SS/SSc" as distinct subsets within the context of connective tissue diseases with different clinical expression and outcomes, thus deserving an individualised assessment and personalised medical interventions.
Published: 2022

128. Clinical and histological findings at second but not at first kidney biopsy predict end-stage kidney disease in a large multicentric cohort of patients with active lupus nephritis

Author: Mariele Gatto, Francesca Radice, Francesca Saccon, Marta Calatroni, Giulia Frontini, Barbara Trezzi, Margherita Zen, Anna Ghirardello, Francesco Tamborini, Valentina Binda, Vincenzo L'Imperio, Andrea Doria, Augusto Vaglio, Renato Alberto Sinico, Gabriella Moroni, Luca Iaccarino, Gatto, M, Radice, F, Saccon, F, Calatroni, M, Frontini, G, Trezzi, B, Zen, M, Ghirardello, A, Tamborini, F, Binda, V, L'Imperio, V, Doria, A, Vaglio, A, Sinico, R, Moroni, G, and Iaccarino, L
Subjects: Inflammation, Male, Lupus Erythematosus, Biopsy, Immunology, Systemic, General Medicine, Lupus Nephriti, Kidney, Lupus Nephritis, Kidney Failure, Proteinuria, Lupus Erythematosus, Systemic, Female, Humans, Retrospective Studies, Kidney Failure, Chronic, Chronic
Abstract: ObjectiveTo investigate second kidney biopsy as predictor of end-stage kidney disease (ESKD) in active lupus nephritis (LN).MethodsPatients with biopsy-proven LN (International Society of Nephrology/Renal Pathology Society 2003) who had undergone a second kidney biopsy between January 1990 and December 2018 were included. Clinical and histological findings at first and at second biopsy were analysed with Cox proportional hazard models to predict ESKD, defined as start of kidney replacement therapy. Survival curves were calculated with Kaplan-Meier method.ResultsNinety-two patients with LN were included, 87% females, mean follow-up 17.9±10.1 years. Reasons for second kidney biopsy encompassed nephritic flares (n=28, 30.4%), proteinuric flares (n=46, 50%) or lack of renal response (n=18, 19.5%). Class switch from first biopsy occurred in 50.5% of cases, mainly from non-proliferative towards proliferative classes. Class IV remained stable in over 50% of cases. Twenty-five patients (27.2%) developed ESKD, mostly belonging to the nephritic flare group (17/28, 60.7%). Independent predictors of ESKD at second biopsy were activity index (AI; (HR 95% CI) 1.20 (1.03 to 1.41), p=0.022), chronicity index (CI; 1.41 (1.09 to 1.82), p=0.008) and 24h-proteinuria (1.22 (1.04 to 1.42), p=0.013). AI≥2 (log-rank p=0.031), CI >4 (log-rank p=0.001) or proteinuria ≥3.5 g/day (log-rank=0.009) identified thresholds for higher ESKD risk. In a subgroup analysis, glomerular activity and tubular chronicity mostly accounted for AI and CI association with ESKD. No histological or laboratory predictors emerged at first biopsy (95% CI): AI: 0.88 to 1.19; CI: 0.66 to 1.20; proteinuria 0.85 to 1.08.ConclusionsFindings at second but not at first kidney biopsy in patients with persistently active or relapsing LN inform about ESKD development in a long-term follow-up.
Published: 2022

129. Predictors of disease activity in gout: a 12-month analysis of the ATTACk (Achieving improvement in the management of crystal-induced arthritis) multicentre cohort study

Author: Mariagrazia, Lorenzin, Nicola, Ughi, Alarico, Ariani, Bernd, Raffeiner, Paola, Frallonardo, Ariela, Hoxha, Augusta, Ortolan, Marta, Favero, Simone, Parisi, Alessandra, Bortoluzzi, Fulvia, Ceccarelli, Ramona, Lucchetti, Federica, Furini, Teresa, Del Ross, Anna, Zanetti, Greta, Carrara, Carlo Alberto, Scirè, Andrea, Doria, Roberta, Ramonda, Marco Amadeo, Cimmino, Lorenzin, M, Ughi, N, Ariani, A, Raffeiner, B, Frallonardo, P, Hoxha, A, Ortolan, A, Favero, M, Parisi, S, Bortoluzzi, A, Ceccarelli, F, Lucchetti, R, Furini, F, Del Ross, T, Zanetti, A, Carrara, G, Scire, C, Doria, A, and Ramonda, R
Subjects: gout, Rheumatology, hypouricaemia treatment, Immunology, gout outcome, gout predictor, Immunology and Allergy, tophi, MED/16 - REUMATOLOGIA, disease activity
Abstract: Objective Gout treatment is largely suboptimal in clinical practice. We aimed to assess the predictors of disease-activity at 12 months in a real-life setting. Methods Consecutive patients referred to Rheumatology Units for suspected acute crystal-induced arthritis were enrolled in a multicentre-cohort study. Only patients with clinical diagnosis of gout were eligible. Disease-activity was evaluated by the Patient Acceptable Symptom State (PASS) on a visual analogue scale (VAS, 0=unsatisfactory, 100=satisfactory) at 0 (T0) and 12 months (T12), and the composite score called Gout Activity Score (GAS) calculated on the number of arthritic attacks (flare count), serum uric acid (sUA), cumulative number of tophi, VAS (T12), PtGA (T12). Multivariate linear regression model was performed to assess predictors of gout disease-activity at T12 with PASS and GAS as outcomes. Results: 201 patients had gout (diagnosis on synovial fluid in 45%, tophi in 26%, mean sUA 7.4±1.9 mg/L, 85% with urate-lowering therapy (ULT) in progress/initiated at T0); mean age 63±13 years, 88% men, median (interquartile range) disease duration 2.9 years (0.7-9.4). Follow-up visits were performed in 113 (56%) patients at T12. Mean PASS observed at T0 and at T12 were 38±27 and 74±23, respectively, whereas GAS at T12 was 10±8. A significant association was observed between the presence of tophi and PASS at T12 (-15.3, 95% CI -25.5, -5.2; p=0.003) and GAS at T12 (+4.0, 95% CI 0.6,7.4; p=0.02), adjusted for age, sex, disease duration, sUA
Published: 2022

130. Prevalence and death rate of COVID-19 in systemic autoimmune diseases in the first three pandemic waves. Relationship to disease subgroups and ongoing therapies

Author: Clodoveo Ferri 1 2, Vincenzo Raimondo 2, Laura Gragnani 3, Dilia Giuggioli 1, Lorenzo Dagna 4, Antonio Tavoni 5, Francesco Ursini 6, Massimo L'Andolina 7, Francesco Caso 8, Piero Ruscitti 9, Maurizio Caminiti 10, Rosario Foti 11, Valeria Riccieri 12, Serena Guiducci 13, Roberta Pellegrini 14, Elisabetta Zanatta 15, Giuseppe Varcasia 16, Domenico Olivo 17, Pietro Gigliotti 18, Giovanna Cuomo, Giuseppe Murdaca 20, Riccardo Cecchetti 21, Rossella De Angelis 22, Nicoletta Romeo 23, Francesca Ingegnoli 24, Franco Cozzi 25, Veronica Codullo 26, Ilaria Cavazzana 27, Michele Colaci 28, Giuseppina Abignano 29, Maria De Santis 30, Ennio Lubrano 31, Enrico Fusaro 32, Amelia Spinella 1, Federica Lumetti 1, Giacomo De Luca 4, Silvia Bellando-Randone 13, Elisa Visalli 11, Ylenia Dal Bosco 11, Giorgio Amato 11, Daiana Giannini 5, Silvia Bilia 5, Francesco Masini 19, Greta Pellegrino 12, Erika Pigatto 25, Elena Generali 30, Giuseppa Pagano Mariano 10, Giorgio Pettiti 23, Giovanni Zanframundo 26, Raffaele Brittelli 2, Vincenzo Aiello 2, Rodolfo Caminiti 2, Daniela Scorpiniti 2, Tommaso Ferrari 16, Corrado Campochiaro 4, Veronica Brusi 6, Micaela Fredi 27, Liala Moschetti 27, Fabio Cacciapaglia 33, Sabrina Rosaria Paparo 34, Francesca Ragusa 34, Valeria Mazzi 35, Giusy Elia 35, Silvia Martina Ferrari 34, Ilenia Di Cola 9, Marta Vadacca 36, Sebastiano Lorusso 36, Monica Monti 37, Serena Lorini 37, Maria Letizia Aprile 28, Marco Tasso 8, Mario Miccoli 34, Silvia Bosello 38, Salvatore D'Angelo 29, Andrea Doria 15, Franco Franceschini 27, Riccardo Meliconi 6, Marco Matucci-Cerinic 13, Florenzo Iannone 33, Roberto Giacomelli 36, Carlo Salvarani 1, Anna Linda Zignego 3, Poupak Fallahi 39, Alessandro Antonelli 35, 1 2, Clodoveo Ferri, 2, Vincenzo Raimondo, 3, Laura Gragnani, 1, Dilia Giuggioli, 4, Lorenzo Dagna, 5, Antonio Tavoni, 6, Francesco Ursini, 7, Massimo L'Andolina, 8, Francesco Caso, 9, Piero Ruscitti, Caminiti 10, Maurizio, Foti 11, Rosario, Riccieri 12, Valeria, Guiducci 13, Serena, Pellegrini 14, Roberta, Zanatta 15, Elisabetta, Varcasia 16, Giuseppe, Olivo 17, Domenico, Gigliotti 18, Pietro, Cuomo, Giovanna, Murdaca 20, Giuseppe, Cecchetti 21, Riccardo, De Angelis 22, Rossella, Romeo 23, Nicoletta, Ingegnoli 24, Francesca, Cozzi 25, Franco, Codullo 26, Veronica, Cavazzana 27, Ilaria, Colaci 28, Michele, Abignano 29, Giuseppina, De Santis 30, Maria, Lubrano 31, Ennio, Fusaro 32, Enrico, 1, Amelia Spinella, 1, Federica Lumetti, 4, Giacomo De Luca, Bellando-Randone 13, Silvia, Visalli 11, Elisa, Dal Bosco 11, Ylenia, Amato 11, Giorgio, 5, Daiana Giannini, 5, Silvia Bilia, Masini 19, Francesco, Pellegrino 12, Greta, Pigatto 25, Erika, Generali 30, Elena, Pagano Mariano 10, Giuseppa, Pettiti 23, Giorgio, Zanframundo 26, Giovanni, 2, Raffaele Brittelli, 2, Vincenzo Aiello, 2, Rodolfo Caminiti, 2, Daniela Scorpiniti, Ferrari 16, Tommaso, 4, Corrado Campochiaro, 6, Veronica Brusi, Fredi 27, Micaela, Moschetti 27, Liala, Cacciapaglia 33, Fabio, Rosaria Paparo 34, Sabrina, Ragusa 34, Francesca, Mazzi 35, Valeria, Elia 35, Giusy, Martina Ferrari 34, Silvia, 9, Ilenia Di Cola, Vadacca 36, Marta, Lorusso 36, Sebastiano, Monti 37, Monica, Lorini 37, Serena, Letizia Aprile 28, Maria, 8, Marco Tasso, Miccoli 34, Mario, Bosello 38, Silvia, D'Angelo 29, Salvatore, Doria 15, Andrea, Franceschini 27, Franco, 6, Riccardo Meliconi, Matucci-Cerinic 13, Marco, Iannone 33, Florenzo, Giacomelli 36, Roberto, 1, Carlo Salvarani, 3, Anna Linda Zignego, Fallahi 39, Poupak, and Antonelli 35, Alessandro
Subjects: autoimmune systemic diseases, Settore MED/16 - Reumatologia, DMARD, COVID-19, aspirin, interstitial lung involvement, steroids, systemic sclerosis, vasculitis
Published: 2022

131. Sex-related Differences in Systemic Sclerosis: A Multicenter Cross-sectional Study From the National Registry of the Italian Society for Rheumatology

Author: Rossella, De Angelis, Dilia, Giuggioli, Gianluigi, Bajocchi, Lorenzo, Dagna, Giovanni, Zanframundo, Rosario, Foti, Fabio, Cacciapaglia, Giovanna, Cuomo, Alarico, Ariani, Edoardo, Rosato, Serena, Guiducci, Francesco, Girelli, Valeria, Riccieri, Elisabetta, Zanatta, Silvia, Bosello, Ilaria, Cavazzana, Francesca, Ingegnoli, Maria De, Santis, Giuseppe, Murdaca, Giuseppina, Abignano, Nicoletta, Romeo, Alessandra, Della Rossa, Maurizio, Caminiti, Annamaria, Iuliano, Giovanni, Ciano, Lorenzo, Beretta, Gianluca, Bagnato, Ennio, Lubrano, Ilenia, De Andres, Alessandro, Giollo, Marta, Saracco, Cecilia, Agnes, Federica, Lumetti, Amelia, Spinella, Luca, Magnani, Corrado, Campochiaro, Giacomo, De Luca, Veronica, Codullo, Elisa, Visalli, Francesco, Masini, Antonietta, Gigante, Silvia, Bellando-Randone, Greta, Pellegrino, Erika, Pigatto, Francesca, Dall'Ara, Maria Grazia, Lazzaroni, Elena, Generali, Gianna, Mennillo, Simone, Barsotti, Giuseppa Pagano, Mariano, Francesca, Calabrese, Federica, Furini, Licia, Vultaggio, Simone, Parisi, Clara Lisa, Peroni, Anna Maria, Risa, Davide, Rozza, Anna, Zanetti, Greta, Carrara, Giampiero, Landolfi, Carlo Alberto, Scirè, Gerolamo, Bianchi, Enrico, Fusaro, Gian Domenico, Sebastiani, Marcello, Govoni, Salvatore, D'Angelo, Franco, Cozzi, Andrea, Doria, Florenzo, Iannone, Carlo, Salvarani, Marco, Matucci-Cerinic, Clodoveo, Ferri, De Angelis, R, Giuggioli, D, Bajocchi, G, Dagna, L, Zanframundo, G, Foti, R, Cacciapaglia, F, Cuomo, G, Ariani, A, Rosato, E, Guiducci, S, Girelli, F, Riccieri, V, Zanatta, E, Bosello, S, Cavazzana, I, Ingegnoli, F, Santis, M, Murdaca, G, Abignano, G, Romeo, N, Della Rossa, A, Caminiti, M, Iuliano, A, Ciano, G, Beretta, L, Bagnato, G, Lubrano, E, De Andres, I, Giollo, A, Saracco, M, Agnes, C, Lumetti, F, Spinella, A, Magnani, L, Campochiaro, C, De Luca, G, Codullo, V, Visalli, E, Masini, F, Gigante, A, Bellando-Randone, S, Pellegrino, G, Pigatto, E, Dall'Ara, F, Lazzaroni, M, Generali, E, Mennillo, G, Barsotti, S, Mariano, G, Calabrese, F, Furini, F, Vultaggio, L, Parisi, S, Peroni, C, Risa, A, Rozza, D, Zanetti, A, Carrara, G, Landolfi, G, Scire, C, Bianchi, G, Fusaro, E, Sebastiani, G, Govoni, M, D'Angelo, S, Cozzi, F, Doria, A, Iannone, F, Salvarani, C, Matucci-Cerinic, M, Ferri, C, de Angelis, R., Giuggioli, D., Bajocchi, G., Dagna, L., Zanframundo, G., Foti, R., Cacciapaglia, F., Cuomo, G., Ariani, A., Rosato, E., Guiducci, S., Girelli, F., Riccieri, V., Zanatta, E., Bosello, S., Cavazzana, I., Ingegnoli, F., de Santis, M., Murdaca, G., Abignano, G., Romeo, N., Rossa, A. D., Caminiti, M., Iuliano, A., Ciano, G., Beretta, L., Bagnato, G., Lubrano, E., de Andres, I., Giollo, A., Saracco, M., Agnes, C., Lumetti, F., Spinella, A., Magnani, L., Campochiaro, C., de Luca, Giacomo., Codullo, V., Visalli, E., Masini, F., Gigante, A., Bellando-Randone, S., Pellegrino, G., Pigatto, E., Dall'Ara, F., Lazzaroni, M. G., Generali, E., Mennillo, G., Barsotti, S., Mariano, G. P., Calabrese, F., Furini, F., Vultaggio, L., Parisi, S., Peroni, C. L., Risa, A. M., Rozza, D., Zanetti, A., Carrara, G., Landolfi, G., Scire, C. A., Bianchi, G., Fusaro, E., Sebastiani, G. D., Govoni, M., D'Angelo, S., Cozzi, F., Doria, A., Iannone, F., Salvarani, C., Matucci-Cerinic, M., Ferri, C., De Angelis, Rossella, Giuggioli, Dilia, Bajocchi, Gianluigi, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Guiducci, Serena, Girelli, Francesco, Riccieri, Valeria, Zanatta, Elisabetta, Bosello, Silvia, Cavazzana, Ilaria, Ingegnoli, Francesca, De Santis, Maria, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Masini, Francesco, Gigante, Antonietta, Bellando-Randone, Silvia, Pellegrino, Greta, Pigatto, Erika, Dall'Ara, Francesca, Lazzaroni, Maria Grazia, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Pagano Mariano, Giuseppa, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Risa, Anna Maria, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Landolfi, Giampiero, Scirè, Carlo Alberto, Bianchi, Gerolamo, Fusaro, Enrico, Sebastiani, Gian Domenico, Govoni, Marcello, D'Angelo, Salvatore, Cozzi, Franco, Doria, Andrea, Iannone, Florenzo, Salvarani, Carlo, Matucci-Cerinic, Marco, and Ferri, Clodoveo
Subjects: Male, medicine.medical_specialty, Vital capacity, Settore MED/16 - REUMATOLOGIA, Cross-sectional study, Immunology, Left, Socio-culturale, scleroderma, sex, systemic sclerosis, Disease, Ventricular Function, Left, Scleroderma, Systemic sclerosi, Rheumatology, Internal medicine, Sicca syndrome, Sex, Systemic sclerosis, Cross-Sectional Studies, Female, Humans, Italy, Registries, Sex Characteristics, Stroke Volume, Scleroderma, Systemic, Sjogren's Syndrome, medicine, LS8_2, Immunology and Allergy, Ventricular Function, Honeycombing, skin and connective tissue diseases, Ejection fraction, integumentary system, business.industry, Systemic, medicine.disease, Cohort, business
Abstract: ObjectiveThere is still a great deal to learn about the influence of sex in systemic sclerosis (SSc). In this respect, national registries provide large and homogeneous patient cohorts for analytical studies. We therefore investigated a wide-ranging and well-characterized SSc series with the aim of identifying sex differences in disease expression, with a special focus on demographic, clinical, and serological characteristics.MethodsA multicenter SSc cohort of 2281 patients, including 247 men, was recruited in the Italian Systemic sclerosis PRogression INvestiGation (SPRING) registry. Demographic data, disease manifestations, serological profile, and internal organ involvement were compared.ResultsThe overall female/male ratio was 8.2:1. Female/male ratios for limited cutaneous SSc, diffuse cutaneous SSc, and SSc sine scleroderma subsets were 8.7:1, 4.9:1, and 10.7:1, respectively. A shorter time from onset of Raynaud phenomenon to SSc diagnosis, an increased prevalence of the diffuse cutaneous subset, renal crisis, and digital ulcers were found in males, whereas a significantly higher percentage of sicca syndrome, serum antinuclear antibodies, antiextractable nuclear antigens, anti-La/SSB, and anticentromere protein B was detected in the female group. Males exhibited lower left ventricular ejection fraction, as well as higher prevalence of conduction blocks, arrhythmias, ground glass, and honeycombing. Moreover, forced vital capacity and total lung capacity were medially lower in men than in women. Finally, males were more frequently treated with immunosuppressive drugs.ConclusionOur study further supports the presence of several sex-related differences in patients with SSc. These differences were pronounced in the severity of cutaneous, peripheral vascular, and cardiopulmonary involvement for male patients, whereas an increased prevalence of sicca syndrome and a specific autoantibody profile characterized the female sex.
Published: 2022

132. Secukinumab Drug Survival in Psoriasis and Psoriatic Arthritis Patients: A 24-Month Real-Life Study

Author: Augusta Ortolan, Mariagrazia Lorenzin, Giovanni Leo, Francesca Pampaloni, Francesco Messina, Andrea Doria, Stefano Piaserico, and Roberta Ramonda
Subjects: Survival, Anti-interleukin-17, Psoriatic arthritis, Arthritis, Psoriatic, Humans, Psoriasis, Dermatology, Antibodies, Monoclonal, Humanized, Secukinumab, Body Mass Index
Abstract: Background: Secukinumab effectiveness has been demonstrated in both psoriasis (PsO) and psoriatic arthritis (PsA). However, it is unknown whether patients with arthritis may carry a risk factor for withdrawal. Objective: To identify predictors of secukinumab survival, including the presence of arthritis, in PsO and PsA. Methods: Consecutive PsO and PsA patients initiating secukinumab were enrolled and followed up every 6 months, up to 24 months or discontinuation. Medical history, disease activity indices and body mass index (BMI) were collected. Kaplan-Meier curves and log-rank test were used to analyze differences in drug survival according to sex, BMI, biological therapy line in the whole population (psoriatic disease), and separately for PsO/PsA. A multivariable Cox regression model was built to assess whether presence of arthritis (main independent variable) may influence drug survival by having time to secukinumab discontinuation as outcome. Results were expressed as hazard ratio and 95% confidence interval. Results: Sixty-two PsO and 90 PsA patients were enrolled. Retention rate at 12 and 24 months, respectively, was 85% and 61% for PsO and 68% and 57% for PsA. In the whole population, naïve patients had a higher chance of drug survival (log-rank = 4.06; p = 0.04); in PsA, obese patients had a significantly higher chance to discontinue secukinumab (log-rank = 5.25; p = 0.021). The multivariable Cox regression showed that arthritis was independently associated with a higher risk of secukinumab discontinuation (hazard ratio 2.43; 95% confidence interval 1.06–5.55, p = 0.035) after adjusting for age, sex, gender, BMI, therapy line and PsO severity at baseline. Conclusions: Our data confirmed a very good response to secukinumab in both PsO and PsA patients. However, presence of arthritis might affect drug survival.
Published: 2022

133. Long-term Outcome of Children Born to Women with Autoimmune Rheumatic Diseases: A Multicentre, Nationwide Study on 299 Randomly Selected Individuals

Author: Carolina Benigno, Elena Bartoloni, Roberto Caporali, Maria Favaro, Chiara Tani, Armin Maier, Angela Ceribelli, M Vadacca, Carlo Salvarani, M. Meroni, Elisa Visalli, Amelia Ruffatti, Alessandra Bortoluzzi, S. Peccatori, Pier Luigi Meroni, Francesco Paolo Cantatore, Salvatore D'Angelo, Giuseppe Paolazzi, Eleonora Valentini, Gian Domenico Sebastiani, Marta Mosca, Elena Generali, Elena Baldissera, Angela Tincani, Giulia Pazzola, Véronique Ramoni, Melissa Padovan, L Zuliani, M Rodrigues, Francesca Serale, Maddalena Larosa, Cecilia Beatrice Chighizola, Rossella Reggia, Valentina Picerno, Rosario Foti, Maria Grazia Lazzaroni, Addolorata Corrado, Francesca Bellisai, Nazzarena Malavolta, Francesca Dall'Ara, Armando Gabrielli, Roberto Gerli, Cecilia Nalli, Elena De Stefani, Giorgio Pettiti, Luigi Sinigaglia, C Carini, Laura Andreoli, Maria Gerosa, Carlomaurizio Montecucco, Fabio Basta, Paola Conigliaro, Roberto Perricone, Maurizio Cutolo, I. Prevete, Corrado Campochiaro, Andrea Doria, Carlo Selmi, N Romeo, M Trevisani, Guido Valesini, Colomba Fischetti, and E Vivaldelli
Subjects: 0301 basic medicine, Male, Pediatrics, medicine.medical_specialty, Offspring, Disease, Autoimmune Diseases, NO, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Rheumatic diseases, Pregnancy, Reproductive issues, medicine, Immunology and Allergy, Humans, Child, Prenatal exposure, Autoantibodies, 030203 arthritis & rheumatology, business.industry, Neurodevelopmental disorders, General Medicine, Maternal autoantibodies, Counselling, Reproductive Issues, 030104 developmental biology, Increased risk, Antirheumatic Agents, Childbearing age, Cohort, Female, business
Abstract: The concern about the offspring’s health is one of the reasons for a reduced family size of women with rheumatic diseases (RD). Increased risk of autoimmune diseases (AD) and neurodevelopmental disorders (ND) has been reported in children born to patients with RD. Within a nationwide survey about reproductive issues of women with RD, we aimed at exploring the long-term outcome of their children. By surveying 398 patients who received their diagnosis of RD during childbearing age (before the age of 45), information about the offspring were obtained from 230 women who declared to have had children. A total of 148 (64.3%) patients were affected by connective tissue diseases (CTD) and 82 (35.7%) by chronic arthritis. Data on 299 children (156 males, 52.1%; mean age at the time of interview 17.1 ± 9.7 years) were collected. Twelve children (4.0%), who were born to patients with CTD in 75% of the cases, were affected by AD (8 cases of celiac disease). Eleven children had a certified diagnosis of ND (3.6%; 6 cases of learning disabilities); 9 of them were born to mothers with CTD (5 after maternal diagnosis). No association was found between ND and prenatal exposure to either maternal autoantibodies or anti-rheumatic drugs. Absolute numbers of offspring affected by AD and ND were low in a multicentre cohort of Italian women with RD. This information can be helpful for the counselling about reproductive issues, as the health outcomes of the offspring might not be an issue which discourage women with RD from having children.
Published: 2022

134. Erosive hand osteoarthritis: latest findings and outlook

Author: Marta Favero, Elisa Belluzzi, Augusta Ortolan, Mariagrazia Lorenzin, Francesca Oliviero, Andrea Doria, Carla R. Scanzello, and Roberta Ramonda
Subjects: Rheumatology, Hand Joints, Osteoarthritis, Quality of Life, Humans, Female, Hand, Biomarkers
Abstract: Osteoarthritis (OA) most commonly affects knee joints, and the next most commonly affected sites are the hands and hips. Three distinct hand OA phenotypes have been described: erosive hand OA (EHOA), nodal hand OA - also known as non-erosive hand OA (non-EHOA) - and first carpometacarpal joint OA. EHOA predominantly affects women and is the most aggressive form of hand OA, characterized by a severe clinical onset and progression, leading to joint damage, disability and reduction of quality of life. Clinical signs of inflammation associated with EHOA include the acute onset of pain, swelling and redness. Moreover, EHOA is characterized by radiographic features such as central erosion, saw-tooth and gull-wing lesions and, rarely, ankylosis. The aim of this Review is to report the latest findings on epidemiology, clinical features, pathology and aetiopathogenesis, biomarkers, imaging modalities and treatments for EHOA. The ongoing development of new hand OA classification criteria should facilitate standardization between studies.
Published: 2022

135. A Discrimination of Healthy and Rotten Hazelnuts Using a THz Imaging Scanner

Author: Manuel Greco, Emilio Giovenale, Fabio Leccese, Andrea Doria, IEEE, Greco, M., Giovenale, E., Leccese, F., and Doria, A.
Subjects: chemical contaminant, phase shift, topology, THz imaging, viruses, Hazelnut, rotten
Abstract: THz radiation is non-ionizing and non-invasive. Exploiting these features, THz technologies could be used to perform inspections on food quality control. The objective of this study is to discriminate healthy and rotten hazelnuts by using a 97 GHz imaging system.
Published: 2022

136. Glucocorticoid tapering and associated outcome in patients with newly diagnosed systemic lupus erythematosus: the real-world GULP prospective observational study

Author: Alberto, Floris, Elisabetta, Chessa, Gian Domenico Sebastiani, Immacolata, Prevete, Florenzo, Iannone, Laura, Coladonato, Marcello, Govoni, Alessandra, Bortoluzzi, Marta, Mosca, Chiara, Tani, Andrea, Doria, Luca, Iaccarino, Franceschini, Franco, Fredi, Micaela, Fabrizio, Conti, Francesca Romana Spinelli, Francesca, Bellisai, Roberto, D'Alessandro, Anna, Zanetti, Greta, Carrara, Carlo Alberto Scirè, Alberto, Cauli, Matteo, Piga, study group on Early SLE of the Italian Society of Rheumatology (SIR), Floris, A, Chessa, E, Sebastiani, G, Prevete, I, Iannone, F, Coladonato, L, Govoni, M, Bortoluzzi, A, Mosca, M, Tani, C, Doria, A, Iaccarino, L, Franceschini, F, Fredi, M, Conti, F, Spinelli, F, Bellisai, F, D'Alessandro, R, Zanetti, A, Carrara, G, Scire, C, Cauli, A, and Piga, M
Subjects: glucocorticoids, Immunology, Immunosuppressive Agent, systemic lupus erythematosus, therapeutics, Glucocorticoid, Rheumatology, Humans, Lupus Erythematosus, Systemic, Prednisone, Immunology and Allergy, Prospective Studies, Immunosuppressive Agents, Human
Abstract: ObjectiveA subanalysis of the multicentre Early Lupus inception cohort was performed to investigate the real-world Glucocorticoids (GCs) Use in newly diagnosed systemic lupus erythematosus (SLE) Patients (GULP).MethodsPatients starting prednisone (PDN) ≥5 mg/day and concomitant hydroxychloroquine or immunosuppressant within 12 months of SLE classification were enrolled. Core set variables were recorded at baseline and every 6 months, including changes in PDN dose, European Consensus Lupus Activity Measurement (ECLAM) and Systemic Lupus International Collaborating Clinics damage index. Regression models analysed predictors of tapering PDNResultsThe GULP study included 127 patients with SLE; 73 (57.5%) tapered and maintained PDN ConclusionTapering PDN
Published: 2022

137. Studies of leaf water content in smart agriculture using THz technologies: a review

Author: Manuel Greco, Fabio Leccese, Andrea Doria, Andrea Taschin, Eduardo De Francesco, Emilio Giovenale, Luca Senni, Gian Piero Gallerano, Greco, Manuel, Leccese, Fabio, Doria, Andrea, Taschin, Andrea, De Francesco, Eduardo, Giovenale, Emilio, Senni, Luca, and Gallerano, Gian Piero
Subjects: Smart agriculture, Terahertz Time-Domain Spectroscopy (THz-TDS), imaging, herbicides, leaf water content, drought-stress
Abstract: In recent years, the concept of smart agriculture has entered our collective daily routine by radically modifying the methods by which crop monitoring was previously carried out. More precisely, the term smart farming focuses its attention on the use technologies already present on the market like, sensors (multispectral, hyperspectral, thermal and terahertz sensors), WNS (wireless sensor network) and drones capable to reduce the human work in the fields, optimizing at the same time the quantity and quality of the products limiting the use of resources, as water, fertilizers, pesticides and herbicides. Recently, one of the most important problem in the field of precision farming is the availability of water; unfortunately, this factor becomes more critical from year to year. To resolve this problem, the first step is to reduce consumption and rationalize the use of water by adjusting the water supply to the needs of the systems in order to increase its yield while saving money. In this respect, the development of non-destructive techniques operating in the THz spectral region has allowed to monitor in real time the water content present in leaves and plants. In fact, due to the strong water absorption and reflection in this spectral region, this feature can be exploited to detect the water content of leaves and plants helping us to intervene promptly in cases where the plant needs water, avoiding so does water stress, but above all trying to use our primary resource adequately by reducing waste. About this, Imaging and Time-Domain Spectroscopy (THz-TDS) techniques have been applied to monitor soil conditions, drought stress and presence of pathogens on the plants. In this review, we focus our attention on the latest research carried out on monitoring the water content present in leaves through THz technologies. Moreover, we pose particular attention in the description of our system set composed by a 97 GHz transmitter-receiver able to analyze the spatial distribution of the water inside a leaf.
Published: 2022

138. Rotigotine Objectively Improves Sleep in Parkinson’s Disease: An Open-Label Pilot Study with Actigraphic Recording

Author: Giovanna Calandra-Buonaura, Pietro Guaraldi, Andrea Doria, Stefano Zanigni, Stefania Nassetti, Valentina Favoni, Sabina Cevoli, Federica Provini, and Pietro Cortelli
Subjects: Neurology. Diseases of the nervous system, RC346-429
Abstract: Sleep disturbances represent important predictors of poor quality of life (QoL) in Parkinson’s disease (PD). This open-label pilot study aimed to objectively assess, by means of actigraphic recording, effect of rotigotine on sleep in PD patients with self-reported sleep complaints. 15 PD patients underwent one-week actigraphic recording before (T0) and during (T1) rotigotine treatment, which was titrated to the dose subjectively improving motor symptoms (4–8 mg/24 h). Sleep disturbances, daytime sleepiness, cognitive performance, QoL, and depression were also evaluated with questionnaires. Actigraphic recordings showed a significant reduction in nocturnal motor activity and mean duration of wake episodes after sleep onset during rotigotine treatment compared to baseline. In 10 patients presenting objective evidence of poor sleep quality at T0 (sleep efficiency ≤ 85%), rotigotine also significantly improved other sleep parameters and further reduced nocturnal motor activity and mean duration of wake episodes. A significant decrease in number and duration of daytime sleep episodes was also observed at T1. Finally we confirmed that rotigotine significantly improves perceived sleep quality and QoL. Our study showed for the first time that rotigotine is associated with an objective improvement of nocturnal and diurnal sleep disturbances in PD patients with self-reported sleep complaints. This study is registered with AIFA-observational study registry number 12021.
Published: 2016
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139. Rare clinical manifestations in systemic lupus erythematosus: a review on frequency and clinical presentation

Author: Chiara Tani, Elena Elefante, Laurent Arnaud, Sofia C. Barreira, Inita Bulina, Lorenzo Cavagna, Nathalie Costedoat-Chalumeau, Andrea Doria, João Eurico Fonseca, Franco Franceschini, Micaela Fredi, Luca Iaccarino, Maarten Limper, Judit Majnik, Gyorgy Nagy, Cristina Pamfil, Simona Rednic, John A. Reynolds, Maria G. Tektonidou, Anne Troldborg, Giovanni Zanframundo, Marta Mosca, and Repositório da Universidade de Lisboa
Subjects: Lung Diseases, Lupus Erythematosus, Hypertension, Pulmonary, Humans, Hepatitis, Autoimmune, Lupus Erythematosus, Systemic, Systemic, Immunology, education, Pulmonary, Lupus Erythematosus, Systemic/complications, Hepatitis, Rheumatology, Hypertension, Immunology and Allergy, Autoimmune
Abstract: © Copyright Clinical and Experimental Rheumatology 2022, Objectives: The purpose of this study was to review the frequency and clinical presentation of the rarest clinical manifestations of systemic lupus erythematosus (SLE). Methods: A list of 6 rare SLE manifestations were defined: gastrointestinal, liver, pulmonary, cardiac, ocular and neurological manifestations. Each topic was assigned to a pair of authors to perform a literature search and article review. Results: In total, 149 articles were included in the literature review: 37 for gastrointestinal manifestations, 6 for liver manifestations, 27 for pulmonary manifestations, 50 for cardiac manifestations, 16 for ocular manifestations, 13 for neurological manifestations. Gastrointestinal disorders included several clinical presentations with variable frequency (from 0.5% to 10.7% of the cases); liver involvement included lupus-related hepatitis (9.3%) and autoimmune hepatitis (2.3%). The rarest pulmonary manifestations identified were shrinking lung syndrome, described in 1.5% of patients, while interstitial lung disease and lupus pneumonia were reported in 4% and 3% of patients respectively. Myocarditis and pulmonary hypertension were also rarely described in SLE patients although ranging from 0.4-16% and 1-14% respectively, depending on the methodology used for its identification. Ocular manifestations in SLE included some rare manifestations (reported in less than 5% of patients) and lupus retinopathy that is described in 1.2-28.8% of patients depending on methods of ascertainment. Aseptic meningitis and chorea were also confirmed as very rare manifestations being reported in less than 1% and in 0.3-2.4% of cases respectively. Conclusions: The results of this literature review provide the basis for a better understanding of some less-known manifestations of SLE and for stressing the need for a higher awareness in diagnostic and therapeutic protocols regarding these rare disease aspects.
Published: 2021
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140. Methotrexate in early rheumatoid arthritis: Is the anchor drug still holding?

Author: Alessandro Giollo, Enrico Fuzzi, and Andrea Doria
Subjects: Arthritis, Immunology, Early, JAK, Monotherapy, Rheumatoid, tsDMARDs, Arthritis, Rheumatoid, Methotrexate, Treatment Outcome, Antirheumatic Agents, Immunology and Allergy, Humans, Janus Kinase Inhibitors, Drug Therapy, Combination, Glucocorticoids
Abstract: Treat-to-target (T2T) is currently the most fashionable strategy for treatment-naïve, early rheumatoid arthritis (RA) patients. A T2T approach can lead to a complete and drug-free disease remission, whereas failure to obtain remission leads to damage early in the disease course. Hence, one should try to achieve high remission rates as early as possible, implementing the best therapeutic strategies available. Methotrexate (MTX) combined with glucocorticoid bridging is the mainstay of T2T. However, MTX is often used suboptimally in RA patients for many reasons, including poor tolerability, low compliance, and safety issues. Recent evidence has suggested that novel targeted synthetic DMARDs (tsDMARDs) such as the Janus-kinase (JAK) inhibitors in combination with glucocorticoids yielded better outcomes in early RA than conventional treatment. Such an approach may have advantages in terms of patients' outcomes, though some concerns about serious adverse events need to be addressed.
Published: 2021

141. An Italian Multicenter Study on Anti-NXP2 Antibodies: Clinical and Serological Associations

Author: Micaela, Fredi, Ilaria, Cavazzana, Angela, Ceribelli, Lorenzo, Cavagna, Simone, Barsotti, Elena, Bartoloni, Maurizio, Benucci, Ludovico, De Stefano, Andrea, Doria, Giacomo, Emmi, Martina, Fabris, Marco, Fornaro, Federica, Furini, Maria Grazia, Giudizi, Marcello, Govoni, Anna, Ghirardello, Luca, Iaccarino, Fiorenzo, Iannone, Maria, Infantino, Natasa, Isailovic, Maria Grazia, Lazzaroni, Mariangela, Manfredi, Alessandro, Mathieu, Emiliano, Marasco, Paola, Migliorini, Carlomaurizio, Montecucco, Boaz, Palterer, Paola, Parronchi, Matteo, Piga, Federico, Pratesi, Valeria, Riccieri, Carlo, Selmi, Marilina, Tampoia, Alessandra, Tripoli, Giovanni, Zanframundo, Antonella, Radice, Roberto, Gerli, and Franco, Franceschini
Subjects: Immunoprecipitation (IP), Myositis, Anti-NXP2, Autoantibodies, Dermatomyositis (DM), Line blot (LB), General Medicine, Dermatomyositis, Italy, Neoplasms, Immunology and Allergy, Humans
Abstract: The identification of anti-NXP2 antibodies is considered a serological marker of dermatomyositis (DM), with calcinosis, severe myositis and, in some reports, with cancer. Historically, these associations with anti-NXP2 antibodies have been detected by immunoprecipitation (IP), but in the last few years commercial immunoblotting assays have been released. The aim of this collaborative project was to analyse the clinical features associated to anti-NXP2 antibodies, both with commercial line blot (LB) and IP. Myositis-specific and myositis-associated autoantibodies were detected in single centres by commercial line blot (LB); available sera were evaluated in a single centre by protein and RNA immunoprecipitation (IP), and IP-Western blot. Sixty patients anti-NXP2+ (NXP2+) positive by LB were compared with 211 patients anti-NXP2 negative with idiopathic inflammatory myositis (IIM). NXP2+ showed a younger age at IIM onset (p = 0.0014), more frequent diagnosis of dermatomyositis (p = 0.026) and inclusion-body myositis (p = 0.009), and lower rate of anti-synthetase syndrome (p
Published: 2021

142. New onset and flare of rheumatic diseases following COVID-19 vaccination are mild and respond well to treatment: 9-month follow-up data from a single centre cohort

Author: Michela Gasparotto, Sara Bindoli, Roberto Padoan, Giacomo Cozzi, Roberto Depascale, Elisabetta Zanatta, Alessandro Giollo, Mariele Gatto, Margherita Zen, Franco Schiavon, Roberta Ramonda, Paolo Sfriso, Andrea Doria, and Luca Iaccarino
Subjects: Rheumatology, Immunology, Immunology and Allergy
Abstract: Anti-COVID-19 vaccines have proved to be effective and well tolerated. Great attention is now being paid to the characterisation of possible adverse events associated to their administration. We report a case series of suspected rheumatic diseases (RDs) following anti-COVID-19 vaccination.We included patients evaluated at first-aid rheumatologic consultancy and at rheumatologic outpatient and inpatient clinic at Padova University Hospital between May and September 2021 presenting with a RD within 30 days after an anti-COVID-19 vaccine dose. Our selection was in accordance with the World Health Organisation guidelines for adverse event following immunisation (AEFI) surveillance. Patients were regularly re-evaluated by telemedicine or face-to-face visit.We identified 30 cases of RD following vaccination: 24 (80.0%) new onsets and 6 (20.0%) flares. Most of patients (76.6%) received the BNT162b2 vaccine. The mean time to RD onset/flare was 12±9 days. The most common manifestations were inflammatory arthritis (40.0%), rheumatic polymyalgia (33.3%) and adult-onset Still's disease (13.3%). At the last FU visit (9.6±2.2 months), 83.3% of patients showed complete response to first- or second-line therapy, 13.3% a partial response and one patient (3.3%) was still experiencing an active disease.Considering the amount of vaccine doses administered during the evaluation period we overall detected a limited number of cases. We noted a clear prevalence of autoinflammatory conditions and seronegative manifestations. The great majority of patients had mild features and showed a good response to therapy.
Published: 2021
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143. Search for New Phenomena in Final States with Two Leptons and One or No b -Tagged Jets at s=13 TeV Using the ATLAS Detector

Author: John-Bjarne Hansen, Maheyer Jamshed Shroff, Clement Helsens, Lorenzo Pezzotti, Otmar Biebel, Peilong Wang, Takuya Nobe, Shahzad Ali, Joseph Mullin, Guy Rosin, Wing Sheung Chan, Jeffrey David Shahinian, Gerjan Bobbink, Simon Berlendis, Dmitry Golubkov, Katharina Schleicher, W. D. Breaden Madden, Kirill Grevtsov, Karel Smolek, Werner Wiedenmann, M. J. Alconada Verzini, Shunichi Akatsuka, Attila Krasznahorkay, Ilija Vukotic, Lukas Ehrke, Petter Nilsson, Panagiotis Gkountoumis, Xiangke Zhang, Rui Yuan, Anna Goussiou, Marco Sessa, Marisilvia Donadelli, Elisabetta Pianori, Blair Daniel Seidlitz, A. V. Kotwal, Daniel Hayden, R. J. Teuscher, Christopher Andrew Garner, Julia Lynne Gonski, S. Pagan Griso, Federico Sforza, Maria-evanthia Tsopoulou, Nikolai Zimine, D. Amidei, Jackson Carl Burzynski, Fabian Alexander Förster, D. Gillberg, Rupert Leitner, Edward Diehl, J. A. Aparisi Pozo, Konstantinos Nikolopoulos, Devin James Mahon, Evgeniy Khramov, Hideyuki Oide, Dugan O'Neil, Andy Chen, Robert Astalos, Emmanuel Monnier, R. S. Orr, R. Hyneman, Roman Lysak, Christian Wiel, Matthieu Robin, S. Calvente Lopez, Gordon Watts, W. Y. Chan, T. S. Lau, J. W. S. Carter, Kevin Nicholas Barends, Rafal Staszewski, Gabija Zemaityte, M. R. Sutton, Li Xu, Kun Liu, Nicholas Adam Styles, R. W. Wölker, Federico Meloni, V. Izzo, Mark Owen, Didier Ferrere, Simone Francescato, Lorenzo Marcoccia, Christos Vergis, Nuno Filipe Castro, Michael James Fenton, Haifeng Li, Luigi Marchese, Dario Barberis, A. G. Clark, Igor Gavrilenko, Matteo Bauce, Puja Saha, Marcel Michael Stanitzki, Evelin Bakos, Junji Tojo, Y. C. Zhu, Paolo Camarri, Stefan Tapprogge, Y. Kulchitsky, Fabrizio Alfonsi, Artur Cardoso Coimbra, Kate Shaw, Lorne Levinson, Adam Jinaru, S. H. Tlou, P. Conde Muiño, Giancarlo Spigo, Kathleen Whalen, Athina Kourkoumeli-Charalampidi, Barbara Wosiek, Trevor Vickey, Olga Zormpa, Phillip Gutierrez, Darij Markian Starko, M. Della Pietra, Xiaohu Sun, Y. S. Ng, Jafar Shojaii, Sarah Whitney Ferguson, Andrea Catinaccio, S. Li, A. Rocchi, Arnaud Ferrari, Lingxin Meng, Marcia Begalli, Ilaria Luise, Sebastian Andreas Merkt, Gideon Bella, Massimo Corradi, Mario Lassnig, A. Maio, Marc Geisen, Teresa Barillari, Marcus Morgenstern, M. K. Ayoub, Matthew Thomas Anthony, Dewen Zhong, G. R. Gonzalvo Rodriguez, Judith Hofer, R. Di Nardo, Shangfeng Yang, Callum Jacob Birch-Sykes, Ljiljana Morvaj, Chikuma Kato, Norbert Wermes, Marjorie Shapiro, Song-Ming Wang, Thomas James Stevenson, H. Herde, Pavol Strizenec, J. Salt, K. Graham, Siegfried Wenig, Raymond Brock, M. N. Agaras, Diptaparna Biswas, A. Rodriguez Rodriguez, Cheng Chen, Yusong Tian, Eric Drechsler, A. Di Ciaccio, Osamu Sasaki, S. George, K. Al Khoury, Abner Soffer, Jana Schaarschmidt, M. Valente, D. Fassouliotis, Trisha Farooque, Alexander Paramonov, Peter Berta, Jacqueline Batley, Sophie Trincaz-Duvoid, Kazuhiko Hara, Thomas Mathisen, Emmanuel Sauvan, Nedaa Asbah, G. Mikenberg, Giovanni Crosetti, Stefania Antonia Stucci, Giovanna Bruni, Klaus Mönig, S. De Castro, Stephen Albert Weber, Magdalena Slawinska, Shaojun Sun, Mark Kruse, Matous Vozak, A. Sbrizzi, Dennis Sperlich, Gareth Adam Bird, Filomena Sopkova, Lewis Joseph Wilkins, Ph. Schune, W-M. Yao, Alison Lister, Sebastien Rettie, K. H. Hiller, Bryan Kortman, Dale Charles Abbott, R. C. W. Henderson, Marija Glisic, Irina Antonela Cioara, Are Sivertsen Traeet, G. Lehmann Miotto, Jason Lea Oliver, Marine Kuna, Soshi Tsuno, S. L. Wu, Hamish Edward Teagle, Sara Strandberg, Tomomi Kawaguchi, Babar Ali, R.-J. Wang, Tracey Berry, Eric Schanet, Abdualazem Fadol Mohammed, Matthias Saimpert, Fabio Cerutti, R. Gupta, James David Shinner, Candice Ruth Basson, Giordon Holtsberg Stark, Daniela Salvatore, Marco Aurelio Diaz, Yumeng Cao, Tim Martin, Bernhard Matthias Flierl, Kerstin Tackmann, Olga Novgorodova, Marlon Barbero, Sicong Lu, Julien Donini, P. A. Delsart, Monika Wielers, C. F. Feng, Adam Edward Barton, D. Su, Gregory Barbour, Lars Henkelmann, Rena Wakasa, A. Tarek Abouelfadl Mohamed, Paul Tipton, Allen Mincer, Anatoly Kozhin, Ryan Justin Atkin, David Francis, Marcello Fanti, A. C. Abusleme Hoffman, Pepijn Johannes Bakker, J. Beringer, J. Walder, Jun Yan, R. F. Coelho Barrue, Jiri Hejbal, Vincent Hedberg, Vadim Bednyakov, Stefan Simion, Angelos Tsiamis, Lily Asquith, Marco Aparo, Eric Ballabene, Garabed Halladjian, Shalu Solomon, Iacopo Longarini, Victor Kukhtin, Stefan Richter, Reiyo Oishi, A. De Maria, Eric Lancon, J. Boudreau, M. Franklin, Mohamed Ouchrif, Michael R. Wessels, Aaron Joseph Kilgallon, Philippe Calfayan, Ioannis Manthos, Heiko Lacker, P. van Gemmeren, Martin Sykora, Francesco Giuli, J. A. Parsons, Yuta Miyazaki, Ester Ricci, Lennart Adam, Tony Kwan, Renat Sadykov, Stefan Koperny, Julie Kirk, Craig Sawyer, Susanne Kersten, Aidan Grummer, Sebastian Grinstein, Silvia Franchino, Yang Yang, Maksim Penzin, Mohamed Belfkir, Marco Vanadia, Koichi Nagai, Theo Jean Megy, P. Sinervo, Wolfgang Mader, Rachael Ann Creager, Paul Jackson, A. Hadef, Benedikt Bergmann, Grigore Tarna, S. R. Paredes Saenz, Sally Seidel, T. Ingebretsen Carlson, C. Diez Pardos, Alberto Annovi, Kosuke Takeda, Darren Price, Fedor Prokoshin, Stephen Hillier, Ivan Gnesi, M.A. Haleem, Noemi Calace, C. Young, Bengt Lund-Jensen, Alexander Melzer, Pierre Savard, Paul Fraser Harrison, M. J. Shochet, Alexandre Rozanov, Daniel Stefaniak Nielsen, Jonas Wuerzinger, Claudio Santoni, Laurelle Maria Veloce, D. Oliveira Damazio, Stephen Jiggins, Todd Seiss, Dj. Sijacki, Max Maerker, Tatiana Klioutchnikova, Claudia Gemme, Francesco Giuseppe Gravili, Ioannis Gkialas, Diana Pyatiizbyantseva, S. Perrella, E. Perez Codina, C. Lacasta, Virginia Ruth Bailey, Miroslav Myska, R. K. Keeler, Luis Hervas, Aaron White, Xiaowen Su, Filip Backman, D. Boscherini, Louis-Guillaume Gagnon, Michele Renda, Yicheng Guo, Andrea Matic, Konstantin Lehmann, Alexandre Lebedev, Zainab Soumaimi, David Cameron, Giulia Ripellino, Liang Li, Tomasz Bold, D. Pietreanu, Sandra Kortner, Susumu Oda, P. Kodys, J. S. Keller, Aaron Foley Webb, Ava Anne Myers, P. Morettini, A. Di Luca, Laurent Serin, M. I. Martínez, R. M. Barnett, Federica Piazza, Francois Vazeille, Jay Ajitbhai Sandesara, Jana Faltova, Alexey Kharlamov, Vadim Kostyukhin, Shixiang Su, Tomas Sykora, Kaushik De, Saverio D'Auria, Valery Schegelsky, Sabrina Groh, Filip Nechansky, A. Di Girolamo, Pavel Shatalov, Mario Campanelli, Jochen Dingfelder, Ryuichi Takashima, Ettore Zaffaroni, Alexander Armstrong, Gabriela Navarro, Veronica Fabiani, J. M. Clavijo Columbie, Damir Duvnjak, D. Sampsonidou, Vakhtang Tsulaia, Shreya Saha, Yuzhan Zhao, Badr-Eddine Ngair, Luigi Sabetta, Philip Phillips, Samuel Silverstein, Chav Chhiv Chau, Philipp Thomas Koenig, Jens Weingarten, A. Koulouris, S. D. Worm, Christian Kahra, K. E. Kennedy, Iza Veliscek, Massimo Lazzaroni, Alexi Gongadze, Giovanni Darbo, Oliver Stelzer-Chilton, L. Martinelli, Marianna Testa, Holly Ann Pacey, Simen Hellesund, Graeme Stewart, S. J. Chen, Yongsun Kim, Pavel Podberezko, Tomoki Saito, Mattias Ellert, Janet Dietrich, Lesya Anna Horyn, Borut Paul Kerševan, Inga Katarzyna Lakomiec, Kamal Saoucha, Francesco Costanza, I. Dawson, Stanislava Sevova, Dongshuo Du, Ioannis Xiotidis, Tom McCarthy, Y. Li, Friedemann Neuhaus, A. J. Beddall, Hajime Nanjo, Alexander Basan, Jannicke Andree Pearkes, Yulin Gao, S. V. Zeißner, H. H. Williams, Giada Mancini, Tomas Komarek, Georgios Iakovidis, C. Wanotayaroj, Jemal Khubua, Andrei Alexandru Geanta, C. Zhu, Y. El Ghazali, M. Moreno Llácer, Bastian Schlag, Hannes Mildner, S. Todorova-Nova, Allison Mccarn Deiana, Hiroaki Hibi, Nicolas Scharmberg, Jun Gao, D. Shaked Renous, Giulia Gonella, Tony Liss, R. Gonçalo, Leonardo Paolo Rossi, Albert Francis Casha, J. Huston, Federica Pasquali, Souad Batlamous, Vanja Morisbak, T. R. Van Daalen, Katsuo Tokushuku, Malik Aliev, Giovandomenico Carducci, K. K. Gan, Maria Giovanna Foti, P. M. Tuts, J. Geisen, Albert Olariu, Andre Schoening, A. Lanza, H. Ten Kate, D. De Pedis, Alberto Stabile, Iwona Grabowska-Bold, Alaettin Serhan Mete, Constantine Papadatos, Huan Yu Meng, Silvia Resconi, Tim Adye, P. J. Hsu, Sigve Haug, Maria-Teresa Dova, Mattias Birman, Joern Grosse-Knetter, Uta Klein, Maria Smizanska, Siegfried Bethke, Caterina Doglioni, Manisha Manisha, Polyneikis Tzanis, Oldrich Kepka, Christof Sauer, Verena Maria Walbrecht, Zdenek Hubacek, Adam Jackson Parker, A. Ventura, Armin Michael Nairz, Stanislav Tokár, J. Ocariz, Petr Sicho, Chrysostomos Valderanis, Yohei Yamaguchi, Gianluca Alimonti, Rainer Stamen, Sergey Barsov, Sergio Grancagnolo, Miriam Watson, Anastasia Kurova, A. T. H. Arce, Damir Fabrice Rassloff, Jacob Julian Kempster, Christos Anastopoulos, Joseph Haley, Thorben Swirski, Y. Amaral Coutinho, Laurent Schoeffel, Brian Petersen, T. Lari, Johannes Frederic Damp, C. Zeitnitz, Paolo Sabatini, Mikhail Demichev, Gianantonio Pezzullo, Auriane Canesse, Namig Javadov, Xiangyu Xie, Arnulf Quadt, Samuel Dysch, Valerio D'Amico, Marcelo Vogel, A. Ezhilov, Tamar Djobava, Luca Clissa, Corentin Allaire, Vadim Gratchev, Tatiana Lyubushkina, Yunyun Fan, Jianqiao Ye, Marco Lavorgna, Marcello Bindi, Alexander Held, Peter Loch, Giorgio Chiarelli, Mihail Chizhov, Eleanor Jones, Bruno Mansoulie, Paul Newman, Carl Gwilliam, Tristan Andrew Ruggeri, Paolo Calafiura, Sinan Kuday, Masahiro Morinaga, R. Camacho Toro, Michel Raymond, Alessia Renardi, Bruce Schumm, Leonardo Merola, Andrea Coccaro, Leonid Kurchaninov, M. J. Kobel, J. P. Mc Gowan, Shoji Asai, Claire Malone, Thomas Lohse, Michele Michetti, Waleed Syed Ahmed, N. E. Pettersson, Guido Gagliardi, Givi Sekhniaidze, D. R. Shope, Adam Elliott Jaspan, Guennadi Borissov, Chuan-Feng Li, D. Xu, Alexei Klimentov, M. J. Oreglia, Geoffrey Gilles, Y. W. Liu, Aliaksei Hrynevich, Arif Bayirli, K. Nakamura, Aytul Adiguzel, Dmitri Tsybychev, Andrea Sansoni, Shigeru Odaka, Kim Katrin Heidegger, Jiangyong Jia, Stefano Terzo, K. Potamianos, L. F. Oleiro Seabra, Ondrej Hladik, Michael Glenn Eggleston, Krisztian Peters, Adrian Chitan, Yoav Afik, Archil Durglishvili, Ralf P. Richter, Ludovico Pontecorvo, Sven Menke, Claudia Seitz, Kevin Kroeninger, Helen Hayward, Elemer Nagy, Benjamin Wynne, Anton Wolf, Nicole Michelle Hartman, Yi Fei Han, Antonio Giannini, Audrey Katherine Kvam, Martine Bosman, B. J. Liu, J. K. R. Meshreki, Stylianos Angelidakis, Janusz Chwastowski, Frederic Deliot, C. Di Donato, Xing Long Li, Sergio Gonzalez-Sevilla, Francesco Spanò, V. S. Lang, S. Falke, Christian Grefe, L. Di Ciaccio, Mohammad Jawad Kareem, Vladislavs Plesanovs, Daniel John Wilbern, Uli Schäfer, Iain Alexander Bertram, Panagiotis Bellos, C. Gonzalez Renteria, J.C. Wang, B. Parida, Petr Tas, A. De Salvo, Radek Novotny, Koji Terashi, Tobias Flick, Gabriele D'amen, Laura Gonella, David Calvet, E. Bergeaas Kuutmann, J. Albert, Luca Franco, J. L. Nagle, P. Martinez Agullo, T. R. V. Billoud, Y. W. Y. Ng, Andrey Ryzhov, Francesco Lacava, Thomas Beermann, Ivan Yeletskikh, J. T. P. Burr, Vladimir Zhulanov, Mogens Dam, Sean Joseph Gasiorowski, Yee Chinn Yap, Giuseppe Salamanna, Ines Ochoa, K. Becker, Zuzana Rurikova, V. Araujo Ferraz, Hadar Yosef Cohen, F. J. Munoz Sanchez, Emma Sian Kuwertz, Tobias Klingl, Michael Rijssenbeek, Fabrizio Trovato, Marian Benedikt Rendel, Oleg Kuprash, Val O'Shea, T. Vazquez Schroeder, Arunika Sahu, Jan Kretzschmar, Yanhui Ma, G. A. Vasquez, Didier Lacour, Ondrej Penc, Margherita Primavera, Matthias Mentink, Gonzalo Enrique Orellana, Josh Moss, Enrique Kajomovitz, M. V. Silva Oliveira, Daniel Lawrence Briglin, Dave Charlton, Aaron Paul O'Neill, Andre Rummler, Craig Buttar, M-S. Barisits, Francesco Ragusa, Vit Vorobel, M. E. Nelson, Lawrence Davou Christopher, Yuta Okazaki, Joseph Patton, Jakob Novak, Omer Ogul Oncel, Yann Coadou, Faig Ahmadov, Blake Burghgrave, Lerothodi Leonard Leeuw, Xuai Zhuang, Samira Hassani, C. 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Bielski, Claude Leroy, James William Cowley, Emma Grace Castiglia, Louis Fayard, Thorwald Klapdor-kleingrothaus, Christos Paraskevopoulos, Savanna Marie Shaw, Bartosz Mindur, Ulrich Landgraf, Noam Hod, Louis Portales, Pavel Tsiareshka, Sascha Dungs, C. Adam Bourdarios, Madalyn Ann McKay, Zhelun Li, Xiaohu Yang, Frank Filthaut, Adriana Milic, Gaogalalwe Mokgatitswane, Guy Koren, J. D. Hansen, Fairouz Malek, Yuan-Tang Chou, C. Dallapiccola, James Cameron Grundy, David Berge, Emily McDonald, Konstantin Belotskiy, Ph. Schwemling, Brianna Lynn Stamas, Yuji Minegishi, M. De Santis, Jianhuan Xiang, Christina Nelson, Philipp Horn, Wendy Taylor, Ralf Hertenberger, Petr Andreevich Gorbounov, Irakli Minashvili, Miaoran Lu, Leszek Adamczyk, Florian Beisiegel, Christina Agapopoulou, Pavel Reznicek, Melike Akbiyik, Leigh Schaefer, Thilo Pauly, Matthew Joseph Basso, Carlo Schiavi, Andrea Knue, Zhibo Wu, C. A. Solans Sanchez, S. Malyukov, Soumya Mohapatra, Gerhard Brandt, Volker Andreas Austrup, Julia Isabell Djuvsland, A. Salvador Salas, Tadej Novak, I. Sayago Galvan, Chiara Meroni, Z. Marshall, M. P. J. Landon, L. Bryngemark, Bruce Yabsley, Johannes Elmsheuser, Alan Mathew Kahn, P. Farthouat, Brian Le, Silvia Auricchio, Loan Truong, L. Brenner, Bruce Barnett, Fabrizio Scuri, Sergey Peleganchuk, E. Rizvi, Filipp Dubinin, Vincent Garonne, Sandro Palestini, Marcel Vreeswijk, Frederic Derue, Jonathan Michael Hays, Cristiano Alpigiani, Hans Krüger, H. Xu, Giuseppe Carratta, T. Moa, Satoshi Higashino, Klaudia Maj, Dominik Duda, Claire David, Bhaskar Dutta, Laurent Duflot, P. H. Hansen, Osamu Jinnouchi, Nicolin Govender, Rustem Ospanov, Mukesh Kumar, Stanislav Nemecek, J. C. Rivera Vergara, Jason Tyler Colt Barkeloo, Vlasios Petousis, William Brooks, Lidija Živković, Andrew Buckley, Stefan Rave, Liron Barak, M. I. Gostkin, T. J. Khoo, Marumi Kado, Patrick Puzo, Alessandra Camplani, Elzbieta Banas, Todd Brian Huffman, J. Del Peso, Gian Luigi Alberghi, Yosuke Takubo, J. A. Aguilar-Saavedra, Thomas Michael Carter, Stefano Rosati, Suvrajeet Sen, Othmane Rifki, M. Pedersen, D. K. Panchal, Ryunosuke Iguchi, Steffen Korn, Peter Kluit, A. Sanchez Pineda, G. Rahal, David Hohn, Dimitrios Matakias, Lennart Rustige, Fares Djama, J. D. Bossio Sola, Jean-Francois Laporte, J. E. Pilcher, Stanley Lai, M. Ghasemi Bostanabad, Fabienne Ledroit-Guillon, Hong Cheng, Giulio Tiziano Forcolin, Yuya Mino, Pamela Ferrari, Giulia Rovelli, Philip Sommer, Sai Neha Santpur, Dylan Pizzi, Sundeep Singh, Govindraj Singh Virdee, J. E. García Navarro, Samyukta Krishnamurthy, Davide Caforio, Ioannis Michail Maniatis, Rosanna Ignazzi, Yu. A. Tikhonov, Paul Moder, Vojtech Pleskot, Andrew Blue, Suyog Shrestha, Z. Liang, Edoardo Maria Farina, Vasiliki A Mitsou, Paul Gessinger-Befurt, Fernando Barreiro, M. A. Principe Martin, J. Navarro-Gonzalez, O. E. Vickey Boeriu, H-C. Schultz-Coulon, Stefan Schlenker, Lorenzo Massa, Adam Trzupek, G. Carlino, Yong’an Liu, Paolo Massarotti, Anamika Aggarwal, Ashley Ellen Mcdougall, Lidia Dell'Asta, Emilio Higón-Rodriguez, Eli Baverfjord Rye, Y. Delabat Diaz, Anne Marie Sickles, Santu Mondal, Arno Straessner, Even Simonsen Haaland, Monica D'Onofrio, Mohamed Zaazoua, Tae Hyoun Park, R. F. Y. Peters, Attilio Picazio, Thorsten Wengler, Alexey Zhemchugov, Dms Sultan, A. Vallier, Katja Hannele Mankinen, A. Bruni, Fabrice Hubaut, H. Atmani, Igor Mandić, Deepak Kar, Ning Zhou, S. Sinha, C. H. Chen, Andrey Sapronov, Konstantinos Ntekas, D. V. Dedovich, Nicolas Berger, Silke Mobius, Frederik Rühr, Anil Sonay, Fernando Monticelli, Wenhao Xu, Peter Krieger, Lluisa-Maria Mir, Mazuza Ghneimat, J. Jimenez Pena, A. Polini, Chris Sander, Nikolina Ilic, Louis Vaslin, Mika Huhtinen, Julien Maurer, Matthias Klein, A. Lopez Solis, Alexey Talyshev, Eimear Isobel Conroy, Tigran Mkrtchyan, Isabelle Wingerter-Seez, A. Bandyopadhyay, Alessandro Tricoli, Stefan Guindon, Simone Michele Mazza, Bernardo Sotto-Maior Peralva, Christopher Lester, F. Fischer, Manuella Vincter, Murtaza Safdari, Joseph M Muse, Andrew White, Guillermo Nicolas Hamity, Benjamin Paul Honan, Anna Lipniacka, Ariella Cattai, Benjamin Gilbert, Alexander Leopold, J. Fuster, Michaela Queitsch-maitland, S. Stärz, M. Alvarez Estevez, Evelin Meoni, Lorenzo Rossini, Vladimir Cindro, Pierre-Hugues Beauchemin, Dominique Anderson Trischuk, Stephen Gibson, Phillip Urquijo, Kentaro Kawade, Jonas Neundorf, Aaron James Armbruster, A. L. Moreira De Carvalho, Hyungsuk Son, Stefania Xella, Jack Macdonald, Stefano Zambito, E. Valdes Santurio, Ewa Stanecka, Enrico Tassi, Marc Weber, J. M. Iturbe Ponce, Mesut Unal, B. Chen, Davide Costanzo, J-P. Meyer, Lucio Cerrito, Krzysztof Janas, David Rousso, H. T. Yang, Benjamin Freund, Frank Sauerburger, P. Klimek, Mark Stockton, Yoichi Ikegami, A. N. Tuna, Fr Pastore, G. Di Gregorio, Daniel Andreas Britzger, John Hobbs, Jeanette Lorenz, David Milstead, Jia Jian Teoh, Ahmed Bassalat, Kevin Einsweiler, V. Fadeyev, Clara Nellist, Giuseppe Iacobucci, Theodoros Georgio Zorbas, Elisabetta Vilucchi, Jens Dopke, Gokhan Unel, Thomas Koffas, Stefan Stonjek, Kaito Sugizaki, A. S. Tee, I. Siral, Richard Brenner, Marisa Sandhoff, Vincenzo Cavasinni, Marco Battaglia, Mauro Citterio, Joseph F. Urban, Aleksandra Dimitrievska, C. Moreno Martinez, Ambrosius Thomas Vermeulen, Lydia Iconomidou-Fayard, Y. Benhammou, I-huan Chiu, Emmerich Kneringer, Takafumi Kodama, Q. Hu, Archana Sharma, Benjamin Trocmé, Oleg Brandt, Petronel Postolache, Mark Hodgkinson, H. Cai, U. Mallik, Tamar Zakareishvili, Katherine Pachal, Alexey Myagkov, Luc Poggioli, C. A. Lee, J. Smiesko, M. Garcia-Sciveres, Yu Nakahama, Fabrizio Petrucci, Petr Balek, J. G. Panduro Vazquez, Jared David Little, A. Kotsokechagia, Stefano Manzoni, S. Gurbuz, Michael Begel, Nabila Wahab Shaikh, Kerstin Lantzsch, Oleg Bulekov, Uriel Barron, Benjamin Haslum Hodkinson, Milene Calvetti, Bartosz Sebastian Dziedzic, Christos Bakalis, Alexander Milov, Christoph Amelung, F. G. Oakham, Aoto Tanaka, Migle Stankaityte, Paolo Iengo, Marco Schioppa, Minoru Hirose, Yuta Sano, Zara Jane Grout, John Kenneth Anders, E. L. Barberio, Federico Celli, C. J. E. Suster, Steven Goldfarb, Z. G. Zhao, Makoto Tomoto, Clara Elisabeth Leitgeb, Katharina Bianca Jakobi, Naoki Kimura, Judita Mamuzic, Till Eifert, C. Rizzi, H. El Jarrari, Viktor Kramarenko, Ryszard Stroynowski, Bakar Chargeishvili, Ahmed Hasib, Frank Ellinghaus, Jiancong Zeng, D. M. Portillo Quintero, Cooper Wagner, Abhishek Sharma, Mykola Khandoga, Fabian Becherer, Andreas Honle, Claire Gwenlan, Marina Rotaru, Ishan Pokharel, Baida Achkar, Michael William O'Keefe, Ariel Schwartzman, Antonio Zoccoli, Kunlin Ran, Jason Peter Gombas, Athanasios Manousos, Alan Peyaud, B. X. Liu, Xin Wu, Abdenour Lounis, Yi Fan Hu, Rong Zhang, Jahred Adelman, Alain Bellerive, Takashi Mitani, Harry Cooke, Christian Nass, G. N. Taylor, Marco Bomben, C. L. Cheng, Nansi Andari, Lianyou Shan, Richard Nisius, Simone Sottocornola, Stergios Kazakos, Shuaiyan Kang, Melissa Ridel, Deshan Kavishka Abhayasinghe, Michael Dührssen, Henso Abreu, Arabinda Behera, Troels Petersen, Francesco Lanni, Nikolai Fomin, Benjamin Brau, Zihang Jia, Nazim Huseynov, Jaroslava Schovancova, Wenge Wang, E. Thomson, Matteo Negrini, L. Zhang, S. Rodriguez Bosca, Seppe Kuehn, R. E. Long, Christian Ohm, Nandish Arjan Gorasia, Q. Ouyang, Alice Polyxeni Morris, Xiaoxiong Wang, Ilya Korolkov, M. G. Alviggi, Peiliang Liu, Zhiqing Zhang, Balazs Konya, Xiaoguang Yue, Ben Bruers, Alicia Wongel, J. A. Valls Ferrer, Sascha Mehlhase, Marco Cristoforetti, L. Aperio Bella, Nikolaos Rompotis, Ruth Poettgen, Gregor Kramberger, Cigdem Issever, Peter Steinberg, Anatoli Romaniouk, Horst Severini, Cyril Becot, C. M. Gee, Trygve Buanes, Kevin Sedlaczek, S. Ozturk, Christopher Don Milke, J. Tanaka, Y. Hernández Jiménez, Wen-Xu Wang, Vladimir Smakhtin, J. O. Nielsen, Aviv Ruben Cukierman, Paolo Bagnaia, Apostolos Tsirigotis, Guang-Ming Zhang, D. Levin, Karsten Köneke, E. von Toerne, Rachid Mazini, Joyful Elma Mdhluli, R. J. Hawkings, J. Chen, D. Pohl, L. F. Gutierrez Zagazeta, Gabriel Alexandru Popeneciu, Marcel Vos, S. Gonzalez Fernandez, Gavin Pownall, M. C. N. Fiolhais, Chuanshun Wei, Georges Aad, Leonid Serkin, Hubert Kroha, Hong Ma, Lara Katharina Schildgen, Cheng Guang Zhu, Matt Zhang, Peter Tornambe, Jennifer Kathryn Roloff, P. J. Clark, M. Rezaei Estabragh, F. G. Diaz Capriles, J. Kroll, A. Pacheco Pages, Hidetoshi Otono, Alexandre Laurier, P. Johansson, William Trischuk, Alexandra Tudorache, Carmen Maidantchik, L. Manhaes de Andrade Filho, A. P. Pereira Peixoto, Eloisa Arena, Alexander Zaitsev, Martin Habedank, Antoine Laudrain, Hella Leonie Snoek, Jean-Francois Grivaz, Christopher Grud, Dmitriy Maximov, Trine Poulsen, P. de Jong, Christopher Samuel Pollard, Claudio Luci, Patrawan Pasuwan, Driss Benchekroun, A. Korn, Oliver Majersky, Robert Hankache, Michael William Phipps, Kunihiro Nagano, M. Sahinsoy, F. L. Castillo, I. Turk Cakir, John Rutherfoord, Florian Urs Bernlochner, Eunchong Kim, Dwayne Patrick Spiteri, Giacomo Artoni, Martin Murin, Jessica Metcalfe, Miroslav Hrabovsky, Kazunori Hanagaki, Benjamin Philip Nachman, I. Bloch, Iurii Naryshkin, Kanae Asai, Alessandro Caltabiano, A. Soloshenko, Thomas Dennis Powell, Reinhard Schwienhorst, Y. Chen, Adelina D'onofrio, Nils Gillwald, Helmut Wolters, Y-H. Chen, Ferdinand Krieter, Mateusz Dyndal, Ewelina Lobodzinska, Toshiaki Kaji, B. M. Waugh, Philipp Do Nascimento Gaspar, Ellis Fawn Kay, Claire Antel, Marcin Stolarski, David William Thomas, Nikola Makovec, Matthias Hamer, K. Bjørke, K. Zhang, Shaun Roe, S. Tzamarias, Farid Ould-Saada, Harry John Lyons, R. Iuppa, Evan Michael Carlson, Olga Rezanova, Samuel Calvet, Bryn Arthur Roberts, Charles Leggett, Fabian Huegging, N. Nishu, Alex Martyniuk, Wolfgang Wagner, Simonetta Gentile, Marie-Hélène Genest, Minghui Liu, Ivan Pogrebnyak, Matteo Franchini, Igor Aleksandrov, Ruth Magdalena Jacobs, Alessandro Lapertosa, Chen Peng, Rute Pedro, Miha Muskinja, J. B. Liu, Patrick Bauer, Benjamin John Rosser, Andrea Doria, Monica Dunford, Daniel Williams, Y. Wu, Atsuhiko Ochi, E. Fullana Torregrosa, M. E. Pozo Astigarraga, Armin Fehr, Laura Perini, Andreas Salzburger, Zachary Pollock, Martin Errenst, Stephen Haywood, S. Van Stroud, Walter Lampl, Shuangxi Wang, William Dale Heidorn, Lorenzo Rinaldi, F. Parodi, M. LeBlanc, Chris Malena Delitzsch, Thomas Paul Charman, Krzysztof Woźniak, Henri Bachacou, Daniel Fournier, David Miller, Eric Edward Corrigan, Nikiforos Nikiforou, Leonardo Carminati, Francesca Ungaro, Christopher Potter, Gabriel Stoicea, Philip Patrick Allport, Christoph Rembser, Gabriel Facini, Etienne Dreyer, Alexander Lincoln Read, Jessica Levêque, Brendon Bullard, Radu Hobincu, R. Gamboa Goni, S. Passaggio, Luiz Caloba, Henric George Wilkens, Sabina Czekierda, Michael A. Strauss, Joel Hengwei Foo, M. Kaneda, Maximiliano Sioli, Marco Delmastro, Fridolin Dittus, Yan Ke, Miao Liu, H. Arnold, G. H. A. Viehhauser, Tomas Davidek, M. Vranjes Milosavljevic, Melissa Yexley, Michael Düren, Danping Huang, Tobias Golling, Adam Bailey, Eleni Myrto Asimakopoulou, Vangelis Vladimirov, Xiaotong Chu, Peter Sherwood, Pavel Starovoitov, Bernhard Meirose, Cristiano David Sebastiani, Marianna Liberatore, Rahul Balasubramanian, M. A. B. do Vale, A. A. Affolder, Lukas Adamek, Antonio Sidoti, Ian Hinchliffe, Emily Ann Smith, Shikma Bressler, Mariya Shiyakova, Feng Lyu, and Danilo Giugni
Subjects: Quark, Physics, Particle physics, Muon, Large Hadron Collider, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, ATLAS experiment, General Physics and Astronomy, Lambda, Coupling (probability), 7. Clean energy, 01 natural sciences, 0103 physical sciences, High Energy Physics::Experiment, Invariant mass, 010306 general physics, Lepton
Abstract: A search for new phenomena is presented in final states with two leptons and one or no $b$-tagged jets. The event selection requires the two leptons to have opposite charge, the same flavor (electrons or muons), and a large invariant mass. The analysis is based on the full Run-2 proton-proton collision dataset recorded at a center-of-mass energy of $\sqrt{s} = 13$ TeV by the ATLAS experiment at the LHC, corresponding to an integrated luminosity of 139 fb$^{-1}$. No significant deviation from the expected background is observed in the data. A four-fermion contact interaction between two quarks ($b,s$) and two leptons ($ee$ or $\mu\mu$), inspired by the $B$-meson decay anomalies, is used as a benchmark signal model. This model is characterized by the energy scale and coupling, $\Lambda$ and $g_*$ respectively. Contact interactions with $\Lambda / g_*$ lower than 2.0 (2.4) TeV are excluded for electrons (muons) at the 95% confidence level, still far below the value which is favored by the $B$-meson decay anomalies. In addition, model-independent limits are set as a function of the selection on the dilepton invariant mass, which allows the results to be reinterpreted in other signal scenarios.
Published: 2021
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144. Diagnosis and management of lung involvement in systemic lupus erythematosus and Sjögren’s syndrome: a literature review

Author: Luca Iaccarino, Roberto Depascale, Luca Quartuccio, Valeria Manfrè, Giulia Del Frate, Andrea Doria, Salvatore De Vita, Michela Gasparotto, and Mariele Gatto
Subjects: medicine.medical_specialty, Pleural effusion, Diseases of the musculoskeletal system, Review, Systemic inflammation, primary Sjogren’s syndrome, pulmonary involvement, systemic inflammation, systemic lupus erythematosus, therapeutic strategies, Rheumatology, Internal medicine, medicine, Orthopedics and Sports Medicine, Respiratory system, Lung, Interstitial Lung Disease in Autoimmune Rheumatic Disorders, business.industry, Amyloidosis, medicine.disease, Lymphoma, medicine.anatomical_structure, RC925-935, Differential diagnosis, medicine.symptom, Complication, business
Abstract: Lung involvement in systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) has extensively been outlined with a multiplicity of different manifestations. In SLE, the most frequent finding is pleural effusion, while in pSS, airway disease and parenchymal disorders prevail. In both cases, there is an increased risk of pre-capillary and post-capillary pulmonary arterial hypertension (PAH) and pulmonary venous thromboembolism (VTE). The risk of VTE is in part due to an increased thrombophilic status secondary to systemic inflammation or to the well-established association with antiphospholipid antibody syndrome (APS). The lung can also be the site of an organ-specific complication due to the aberrant pathologic immune-hyperactivation as occurs in the development of lymphoma or amyloidosis in pSS. Respiratory infections are a major issue to be addressed when approaching the differential diagnosis, and their exclusion is required to safely start an immunosuppressive therapy. Treatment strategy is mainly based on glucocorticoids (GCs) and immunosuppressants, with a variable response according to the primary pathologic process. Anticoagulation is recommended in case of VTE and multi-targeted treatment regimens including different drugs are the mainstay for PAH management. Antibiotics and respiratory physiotherapy can be considered relevant complement therapeutic measures. In this article, we reviewed lung manifestations in SLE and pSS with the aim to provide a comprehensive overview of their diagnosis and management to physicians taking care of patients with connective tissue diseases.
Published: 2021

145. Erratum to: Search for diboson resonances in hadronic final states in 139 fb−1 of pp collisions at √s = 13 TeV with the ATLAS detector

Author: M. Franklin, Philippe Calfayan, Ioannis Manthos, P. van Gemmeren, Martin Sykora, Gabriel John Facini, Michel Janus, Francesco Giuseppe Gravili, Valerio Bortolotto, Dirk Duschinger, Nico Giangiacomi, Laurent Serin, Edgar Kellermann, Andrew Chisholm, Kaushik De, Damir Duvnjak, Georgios Iakovidis, Daniela Boerner, Albert Olariu, Mikhail Demichev, Samuel Dysch, Valerio D'Amico, Marcelo Vogel, A. Ezhilov, Libor Nozka, A. Onofre, Jan Stark, Ingo Bloch, L. A. M. Wiik-Fuchs, Henry Lubatti, Marta Maria Perego, E. Yu. Soldatov, Raquel Pezoa, Louis D'eramo, Niklaus Lehmann, K. O. H. Vadla, Lidia Smirnova, Laurent Chevalier, Tetiana Hryn'ova, Louie Corpe, Kerstin Jon-And, Yanjun Tu, Kiyotomo Kawagoe, Daniel Guest, Tairan Xu, Giuseppe Lerner, Michael Ughetto, Milos Lokajicek, Mariusz Przybycien, Michael Andrew Parker, Tyler James Burch, Y. Kulchitsky, Liang Guan, Elias Michael Ruttinger, Calin Alexa, Fabrizio Napolitano, Y. Zhang, Stephanie Majewski, Ulrich Parzefall, M. Ziolkowski, Scott Snyder, Brian Moser, Carlos Lacasta, Masaya Ishino, R. Goncalves Gama, Amanda Steinhebel, Vincent Garonne, Sandro Palestini, Robert Les, Oleg Brandt, Didier Alexandre, J. Llorente Merino, Tingting Cao, Remi Lafaye, N. L. Abraham, Radim Slovak, B. R. Mellado Garcia, Johannes Erdmann, Sara Ghasemi, Naim Bora Atlay, H. Zhang, Philippe Mermod, Alexander Sakharov, Joseph Haley, Thorben Swirski, F. Wang, Michel Vetterli, Heidi Sandaker, Sten Hellman, Steve Muanza, Alexis Roger Louis Vallier, R. Cherkaoui El Moursli, Dimitrios Sampsonidis, R. Teixeira De Lima, Imma Riu, Rebecca Anne Linck, J. Manjarres Ramos, W. K. Di Clemente, Daniil Ponomarenko, Krzysztof Ciesla, Tomas Sykora, Valery Schegelsky, Sabrina Groh, Filip Nechansky, J. Chudoba, Fabian Wilk, Kevin Hildebrand, Bostjan Macek, L. Pedraza Diaz, A. Cueto, Y. Amaral Coutinho, Francesco Guescini, J. Barreiro Guimarães da Costa, Michela Paganini, Sergey Burdin, Dmitry Emeliyanov, Yasuhiro Makida, D. Vazquez Furelos, Jorge Andres Lopez Lopez, Baptiste Ravina, C. Schmitt, Bing Zhou, Martin Kocian, M. Garcia-Sciveres, Yu Nakahama, L. F. Flores, M. I. Gostkin, Sally Seidel, Steve McMahon, U. Soldevila, Laurent Schoeffel, Robert Gardner, Joaquin Hoya, Jack Henry Lindon, Stefano Manzoni, A. Sanchez Pineda, G. Rahal, Massimo Lazzaroni, Simen Hellesund, W. Y. Chan, Nabila Wahab Shaikh, Gianluca Introzzi, Y. W. Liu, Eva Hansen, Ryan Christopher Edgar, Martina Laura Ojeda, Zoya Karpova, Ki Lie, Helge Christoph Beck, Andrea Sansoni, Francesco Cirotto, Kyungeon Choi, Nicola Semprini-Cesari, Andrew Ferrante, Zachary Michael Schillaci, Kira Abeling, Martin Spousta, Fumihiko Ukegawa, Andrea Formica, Kentaro Kawade, Kerstin Lantzsch, Milene Calvetti, Oldrich Kepka, Oxana Smirnova, Christoph Falk Anders, Atanu Pathak, Akihiro Higashida, Daniel Lellouch, Wei Wang, Martine Bosman, Venetios Polychronakos, Sergio Gonzalez-Sevilla, Giulio Tiziano Forcolin, Pamela Ferrari, Dominique Pallin, Christos Bakalis, Armin Michael Nairz, Marzieh Bahmani, Konstantinos Bachas, Maike Christina Hansen, Michael Pitt, Laurent Vacavant, Sw. Banerjee, Suyog Shrestha, Steffen Maeland, S. Chen, Jovan Mitrevski, Luigi Longo, S. De Cecco, E. K. U. Gross, Göran Jarlskog, Sebastian Heer, Jannik Geisen, Marco Schioppa, Nikolaos Konstantinidis, Sebastian Mergelmeyer, R. D. Schamberger, Hanna Maria Borecka-Bielska, Giancarlo Spigo, Kathleen Whalen, John Kenneth Anders, S. Marti-Garcia, Vasiliki A Mitsou, Hongfang Liu, Ondrej Hladik, Athina Kourkoumeli-Charalampidi, Tomas Jakoubek, Krisztian Peters, Pascal Pralavorio, T. R. V. Billoud, Daniele Zanzi, Gonzalo Enrique Orellana, Lamberto Luminari, Simon Holm Stark, Shuwei Ye, Branislav Ristic, Y. W. Y. Ng, C. Garcia-Argos, Andrey Ryzhov, Andrea Bocci, Per Edvin Sidebo, Alberto Aloisio, Isabel Nitsche, Maciej Trzebinski, Vladimir Zhulanov, P. S. Wells, Alix Fell, Brian Le, Tetiana Moskalets, Loic Valery, Ryszard Stroynowski, Emily Marie Duffield, Valerio Ippolito, Agnieszka Ewa Ogrodnik, Polina Nechaeva, Esra Mohammed Shrif, Marco Valente, I. P. J. Shipsey, Deepak Kar, M. A. Pleier, Ji Zhu, Stuart Derek Walker, Gabriella Sciolla, A. Polini, Qiang Li, Bakar Chargeishvili, Jianming Qian, Andrew Hard, Markus Cristinziani, Nadav Michael Tamir, Efstathios Karentzos, Ivan Sykora, Abraham Seiden, Daniel Lawrence Briglin, Dave Charlton, Rachel Hyneman, Hulin Wang, Monique A. M. Gignac, Emmanuel Sauvan, Nedaa Asbah, S. De Castro, Thomas Meideck, Konstantin Beloborodov, Alexey Anisenkov, Nikita Belyaev, Ann Miao Wang, G. Duckeck, Vaclav Vacek, V. Andrei, Federica Legger, Elizaveta Shabalina, Harry James Moss, Sanmay Ganguly, P. Gadow, Sergey Karpov, Johannes Josef Junggeburth, Kenji Hamano, Corinne Goy, Shyam Balaji, Ahmed Hasib, Gabriella Gaudio, Cecilia Tosciri, Stanislav Pospisil, Louis Fayard, Thorwald Klapdor-kleingrothaus, Savanna Marie Shaw, A. Mirto, Stephen Albert Weber, Magdalena Slawinska, Shaojun Sun, Marc Escalier, Victor Solovyev, Clara Troncon, Sabrina Sacerdoti, I. M. Gregor, Tetsuro Mashimo, Hassane Hamdaoui, Luka Kanjir, Peter Charles Mcnamara, Stefania Xella, Fr Pastore, Jeanette Lorenz, David Milstead, Jia Jian Teoh, Ahmed Bassalat, Kevin Einsweiler, Fabian Becherer, Victor Maleev, Karl Jakobs, Ambrosius Thomas Vermeulen, Garabed Halladjian, Andreas Honle, Alyssa Montalbano, John Baines, S. Ketabchi Haghighat, E. V. Bouhova-Thacker, Timothy Andeen, Adam Maxwell Azoulay, E. Petit, Andrey Minaenko, Ariel Schwartzman, Stefania Spagnolo, Peter Johannes Falke, Klaus Hamacher, Tatiana Klioutchnikova, Terry Richard Wyatt, A. T. Watson, James Boyd, J. A. Wilson, Carlo Enrico Pandini, M. De Santis, Daniel Muenstermann, Nicolas Morange, Chung-Yau Lo, Andrey Soukharev, A. Nag Nag, Sergei Chekanov, Ourania Sidiropoulou, Sinem Simsek, Jonathan Butterworth, Julia Hrdinka, P. J. Clark, P. H. Sales De Bruin, Anum Qureshi, David DeMarco, J. M. P. Pasner, C. Young, Nurcan Ozturk, Nacim Haddad, Emre Celebi, Olivier Arnaez, Alexandra Tudorache, C. A. Solans Sanchez, Matthew Berg Epland, Giulia Gonella, Jelena Jovicevic, Kohei Yorita, Nansi Andari, Lianyou Shan, Richard Nisius, Cristinel Diaconu, O. Cakir, Virginia Ruth Bailey, Mario Campanelli, Joseph Reichert, Markus Schumacher, Elliot Lipeles, Saleh Sultansoy, Antonio Salvucci, S. Timoshenko, Russell James Turner, Laurie Iain McClymont, Haiping Peng, Borut Paul Kerševan, Anjishnu Bandyopadhyay, Janet Dietrich, Gustaaf Brooijmans, Lesya Anna Horyn, Tom McCarthy, Y. Li, Kilian Rosbach, Ehud Duchovni, Alexander Zaitsev, Koki Maekawa, Takahiro Fusayasu, Anjali Krishnan, Helena Santos, Gabriela Navarro, Veronica Fabiani, Melissa Ridel, Deshan Kavishka Abhayasinghe, Aranzazu Ruiz-Martinez, Giovandomenico Carducci, G. A. Chelkov, Sebastien Rettie, Amal Vaidya, Andre Schoening, Laura Jean Bergsten, S. V. Zeißner, Shi Che, Zihao Jiang, Yoav Afik, Timon Heim, J. Machado Miguens, A. Lanza, P. J. 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Oreglia, Jean-Francois Laporte, Balazs Konya, Ina Carli, Andrew Blue, Peter Schacht, Geoffrey Gilles, Martin Spangenberg, Shigeru Odaka, Giuseppe Avolio, Givi Sekhniaidze, Juraj Smiesko, Roberto Spighi, Christopher Meyer, Sylvain Tisserant, Wolfgang Walkowiak, Jennet Dickinson, Christopher Deutsch, Christopher Samuel Pollard, Claudio Luci, Patrawan Pasuwan, Driss Benchekroun, Kunihiro Nagano, Shensheng Han, Trygve Buanes, J. Tanaka, F. A. Di Bello, Lidia Dell'Asta, Xuanhong Lou, Kathryn Grimm, Nikolai Marcel Hartmann, M. Morii, Uli Schäfer, Evangelos Gkougkousis, Sofia Adorni, Clement Camincher, E. Bergeaas Kuutmann, J. Albert, Masao Saito, V. Dao, H. Ten Kate, Simona Serena Bocchetta, A. Ventura, Y. Hernández Jiménez, Masahiro Yamatani, T. Ženiš, Fabrizio Trovato, Francesco Ragusa, Dimitris Varouchas, I. Lopez Paz, Yury Ryabov, Oleg Kuprash, V. Castillo Gimenez, Fabrice Hubaut, Ben Carlson, M. Wittgen, Petr Sicho, R. S. P. Mueller, Auriane Canesse, Carlos Escobar, E. D. Mendes Gouveia, Speranza Falciano, Geoffrey Mullier, Fabrice Balli, Tobias Kupfer, Georgios Zacharis, Alexander Gavrilyuk, Apostolos Tsirigotis, D. Levin, Bianca Monica Ciungu, C. A. Johnson, Jyoti Prakash Biswal, Karsten Köneke, E. von Toerne, Henrik Oppen, Jing Wang, Julien Caudron, Juraj Bracinik, Vit Vorobel, N. D. Dann, Petr Jacka, Manfredi Ronzani, Zineb Idrissi, John Rutherfoord, Dwayne Patrick Spiteri, Xiaohu Sun, Douglas Davis, Toshi Sumida, Diane Cinca, Fabien Jeanneau, Luca Fiorini, Jianqiao Ye, Marco Lavorgna, Frederic Deliot, J. J. Lozano Bahilo, Jacob Henry Rawling, Jing Guo, Patrick Scholer, Asma Hadef, Rachid Mazini, Joyful Elma Mdhluli, Tomoya Iizawa, Lydia Brenner, Emily Nurse, Merve Sahinsoy, D. Pohl, J. K. K. Liu, Elizabeth Gallas, Antonio Boveia, Gabriel Palacino, Arthur Rene Chomont, Jonathan Shlomi, W. Fedorko, Victor Sorin Martoiu, Bmm Allbrooke, Takanori Kono, Petr Balek, A. T. Doyle, Gregorio Bernardi, Johannes Balz, C. 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Andreazza, Evgeniy Khramov, Andrew Washbrook, Emilio Higón-Rodriguez, L. B. A. H. Hommels, M. Rescigno, Michael Hance, Yuji Minegishi, J. W. Smith, Carlos Sandoval, Tasneem Rashid, Will Davey, Alberto Cervelli, Maria Giulia Ratti, J. Kroll, A. Pacheco Pages, Nguyen Phuong Dang, Hidetoshi Otono, Torre Wenaus, A. J. Barr, Julian Wollrath, Yoram Rozen, F. Luehring, R. M. Faisca Rodrigues Pereira, Andreas Redelbach, Hiroshi Sakamoto, T. S. Lau, Luca Martinelli, Gen Kawamura, Are Sivertsen Traeet, Kevin Black, Y. Delabat Diaz, A. G. Clark, Ahmet Bingul, Elzbieta Richter-Was, Michal Marcisovsky, Adam James Bozson, Martin Aleksa, Elliott Cheu, Lotte Ansgaard Thomsen, Ferdinand Schenck, F. Lasagni Manghi, Dominic Hirschbuehl, Srinivasan Rajagopalan, Anne Marie Sickles, Matthew Edgar Leblanc, G. Lehmann Miotto, C. M. Vergel Infante, O. 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Alconada Verzini, Cigdem Issever, Muhammad Alhroob, Aaron Michael Soffa, Jean-Pierre Meyer, Damiano Vannicola, Robert Leone, Constantine Papadatos, Silvia Resconi, Mazuza Ghneimat, Tim Adye, Verena Maria Walbrecht, R. D. Kass, Zdenek Hubacek, Nuno Filipe Castro, Haifeng Li, Luigi Marchese, Marco Milesi, Benjamin John Rosser, Andrea Doria, Horst Oberlack, Natalie Wieseotte, John Andrew Raine, Philipp Fleischmann, Tatyana Kharlamova, Florencia Luciana Castillo, Chiara Arcangeletti, J. W. S. Carter, Alan Litke, Mieczyslaw Witold Krasny, Friedrich Hoenig, J. S. Lange, Giancarlo Panizzo, Zhi Zheng, Rafal Staszewski, Jakub Andrzej Kremer, Yun Tian, M. Vicente Barreto Pinto, K. Bjørke, Pierfrancesco Butti, Andrej Gorišek, Daniele Madaffari, L. K. Gladilin, Antinea Guerguichon, M. Tanaka, Y. Benhammou, Ryu Sawada, Anna Lipniacka, Juansher Jejelava, Evgueni Ladygin, Keisuke Yoshihara, A. 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Rauscher, P. Skubic, Emery Nibigira, M. Del Gaudio, Dominik Derendarz, Johan Sebastian Bonilla, J. Beringer, J. Griffiths, Marco Scodeggio, Antonio Giannini, Audrey Katherine Kvam, Michel Lefebvre, Miroslav Myska, Elliot Reynolds, Rosy Nicolaidou, Francesco Gonnella, Mark Neubauer, Giorgi Arabidze, Kosuke Takeda, Darren Price, Fedor Prokoshin, Pierre Savard, Paul Fraser Harrison, Takuya Honda, D. Oliveira Damazio, Janusz Chwastowski, Sharka Todorova-Nova, Matthew Craig Mondragon, Frued Erik Braren, P. U. E. Onyisi, A. Di Girolamo, Edson Carquin, Fumiya Yamane, Christian Grefe, Robert Johannes Langenberg, L. Di Ciaccio, Mohammad Jawad Kareem, Pavel Murin, S. Willocq, Matthew Glenn Kurth, Vincenzo Canale, Vakhtang Tsulaia, Pavel Podberezko, Stewart Patrick Swift, Sarah Louise Barnes, David Cameron, John Stupak, Tomas Blazek, Giulia Ripellino, Julian Constantin Schmoeckel, Tomasz Bold, Yuta Okazaki, Yann Coadou, Faig Ahmadov, Blake Burghgrave, Karishma Sekhon, Salah-eddine Dahbi, Monica Dobre, Felix Fidelio Klitzner, Thibault Guillemin, Caterina Marcon, Umar Gul, Siegfried Bethke, Caterina Doglioni, Stanislav Tokár, J. Ocariz, Arnaud Duperrin, Heather Gray, Steven Williams, Andrey Karyukhin, M. Reale, R. M. Barnett, S. Y. Suzuki, Riccardo Vari, Maria Pilar Casado, Dennis Perepelitsa, Emma Tolley, Michaela Mlynarikova, Ian Brock, G. Eigen, Hicham Atmani, Mirta Dumancic, S. J. Chen, F. Safai Tehrani, Adrian Buzatu, R. Kowalewski, Andrei Alexandru Geanta, Albert Francis Casha, Robert Stanek, J. Huston, Souad Batlamous, Vanja Morisbak, T. R. Van Daalen, Tobias Flick, Gabriele D'amen, Lukasz Zwalinski, Andreas Reiss, Masahiro Morinaga, Sheena Schier, D. Camarero Munoz, Chrysostomos Valderanis, Yohei Yamaguchi, Peter Kodys, Venugopal Ellajosyula, Val O'Shea, T. Vazquez Schroeder, Aishik Ghosh, Paolo Morettini, Silvia Biondi, Alessia Murrone, Peter Buchholz, George Dyckes, K. F. Di Petrillo, Zdenek Dolezal, Mark Sutton, Abdeslam Hoummada, Laura Jeanty, Luca Pizzimento, Krystsina Petukhova, Alexandros Marantis, R. R. M. Fletcher, R. de Asmundis, Marek Tasevsky, Matthias Danninger, Dylan Perry Kisliuk, Uladzimir Kruchonak, R. W. L. Jones, Ovsat Abdinov, Oleg Zenin, Ismet Siral, J. Rothberg, Dimitrios Iliadis, Goetz Gaycken, Steven Worm, Sabine Crépé-Renaudin, Stavros Maltezos, Carsten Daniel Burgard, Bernd Stelzer, Maria Florencia Daneri, Kingman Cheung, Josu Cantero, N. B. Sinev, Hiroyuki Iwasaki, John-Bjarne Hansen, Bogdan Malaescu, Christopher John Mcnicol, J-Y. Hostachy, A. Baroncelli, Baojia Tong, Alec Swenson Drobac, E. Le Guirriec, Clement Helsens, Lorenzo Pezzotti, S. Tapia Araya, Yasuyuki Okumura, Dmitry Golubkov, Katharina Schleicher, W. D. Breaden Madden, Nihal Brahimi, Fabian Alexander Förster, J. A. Aparisi Pozo, Alexander Emerman, D. P. J. Lack, Tohru Takeshita, Luca Colasurdo, S. Calvente Lopez, Gordon Watts, Andrea Coccaro, Sergey Senkin, Bo Liu, Veysi Erkcan Ozcan, Stefanie Morgenstern, Iskander Ibragimov, Wen Guan, Shreya Saha, Tomas Komarek, Florian Christoph Fischer, Moritz Backes, Nikolaos Tsirintanis, Artur Cardoso Coimbra, Sofia Chouridou, Maria-Teresa Dova, Alexander Sydorenko, Patrick Fassnacht, P. D. Thompson, Herjuno Rah Nindhito, Uta Klein, Kate Shaw, Maria Smizanska, Lorne Levinson, M. Li, A. V. Akimov, Michel Raymond, Bruce Schumm, Jonathan Long, K. J. R. Cormier, Efe Yigitbasi, S. A. Olivares Pino, Jolanta Olszowska, Trevor Vickey, Phillip Gutierrez, Charles Delporte, Leonardo Merola, K. Nakamura, Aytul Adiguzel, Dmitri Tsybychev, Chiara Grieco, Georges Azuelos, Thomas James Neep, Matthew Thomas Anthony, G. R. Gonzalvo Rodriguez, Kim Katrin Heidegger, Josh Mcfayden, M. Stegler, Dalila Salamani, Thomas LeCompte, Andrew Pilkington, Vitaliano Chiarella, Bobby Samir Acharya, H. A. Neal, Barry King, S. C. Lee, Hannah Herde, C. M. Hawkes, Pavol Bartos, Marina Cobal, Michael Edward Nelson, B. Martin dit Latour, Chikuma Kato, Song-Ming Wang, Jana Schaarschmidt, Matous Vozak, Dennis Sperlich, Jiri Masik, Oleg Fedin, C. P. Ward, Yohei Noguchi, Ewan Hill, Tim Scanlon, Stanislav Suchek, Christos Leonidopoulos, V. M. M. Cairo, Stamatios Gkaitatzis, Isabel Marian Trigger, F. Lo Sterzo, Mauro Villa, James Frost, Pier-Olivier Deviveiros, Jonas Strandberg, David Malon, Anna Kaczmarska, Gilberto Giugliarelli, Christian Weber, Guillaume Unal, Amir Farbin, A. Artamonov, Daniela Bortoletto, Shigeki Hirose, D. Bakshi Gupta, Tadamitsu Kishimoto, T. Kuhl, Janina Anna Krzysiak, Dimitrii Krasnopevtsev, Andrey Kiryunin, Peter Nemethy, Siarhei Harkusha, Mario Sannino, M. A. Nomura, L. Masetti, J. C. Hill, Julien-christopher Beyer, R. Piegaia, Elmar Ritsch, Verena Herget, Nello Bruscino, Philipp Stolte, Flavia De Almeida Dias, Robert Adam Vallance, Iacopo Vivarelli, Reda Tafirout, Klaus Kurt Desch, Richard Nickerson, Francisco Alonso, Arnaud Lucotte, Georgios Stavropoulos, Y. A. Kurochkin, Liza Mijović, E. Torrence, Viktor Sinetckii, Ben Smart, Augusto Santiago Cerqueira, Dmytro Hohov, Alexander Kupco, Edoardo Gorini, Evgeny Starchenko, C. Padilla Aranda, Koji Sato, D. Álvarez Piqueras, S. Yu. Sivoklokov, H. Duran Yildiz, J. Montejo Berlingen, Giuseppe Callea, Pierre-Francois Giraud, Ian Dawson, Mathieu Benoit, Saskia Falke, Xuan Yang, Mihail Chizhov, Yuji Yamazaki, Lewis James Armitage, Jinhong Yu, Veronika Magerl, Bruno Mansoulie, Paul Newman, D. Xu, Alexei Klimentov, Alexander Undrus, Anton Wolf, D. Berge, Calum Michael Macdonald, Steven Patrick Alkire, Simon Henry Connell, Tatsuya Masubuchi, Oliver Keith Baker, Jiri Kvita, Iain Alexander Bertram, Elisa Fumagalli, Francesco Crescioli, Victoria Jane Martin, Cecile Deterre, John Alison, Sara Valentinetti, Tobias Klingl, Michael Rijssenbeek, Frank Winklmeier, L. R. Flores Castillo, Emily Charlotte Graham, A. Abed Abud, Andre Rummler, Jad Zahreddine, Christine Kourkoumelis, Pedro Jorge, Juan Terron, Frederic Schroeder, Xiaocong Ai, Fang-ying Tsai, Simone Monzani, Olaf Nackenhorst, Chiara Debenedetti, H. J. Cheng, Mauro Iodice, Ruggero Turra, Maia Mosidze, S. González de la Hoz, Bernard Brickwedde, M. Beretta, Thomas Naumann, Saminder Dhaliwal, Riccardo-Maria Bianchi, K. H. Hiller, Dale Charles Abbott, R. C. W. Henderson, Joseph Izen, R. Gupta, M. J. Shochet, Aimilianos Koulouris, Alexandre Rozanov, T. Kobayashi, Yakov Petrovich Kulinich, D. Gillberg, Rupert Leitner, Chloe Gray, Luigi Vigani, Edward Diehl, Konstantinos Nikolopoulos, Devin James Mahon, Puja Saha, Daniel Stefaniak Nielsen, Claudio Santoni, Stephen Jiggins, Ruslan Mashinistov, Quentin Buat, Alessandra Ciocio, Pavel Shatalov, K. Sliwa, Kurt Keys Hill, Stephanie Zimmermann, Marcel Michael Stanitzki, Junji Tojo, Y. C. Zhu, Paolo Camarri, Stefan Tapprogge, Stephen Burns Menary, Jochen Dingfelder, Alex Kastanas, Alaettin Serhan Mete, Chaowaroj Wanotayaroj, Massimo Corradi, Mario Lassnig, A. Maio, Cheng Chen, Eric Drechsler, Bibhuti Parida, A. Di Ciaccio, Cong Geng, R. F. H. Hunter, Nathan Rogers Bernard, Driss Goujdami, Pepijn Johannes Bakker, Nima Sherafati, David Calvet, Gregory David Hallewell, Jiri Dolejsi, Alastair Dewhurst, Heinz Pernegger, Alexander Oh, Hisaya Kurashige, Martin Klassen, R. El Kosseifi, H. L. Zhu, Cesare Bini, Zhen Yan, Michael Kagan, Rodney Walker, Ke Li, David Robert Wardrope, Didier Ferrere, Marcus Morgenstern, Trisha Farooque, and Alexander Paramonov
Subjects: transverse momentum: high, Atlas detector, 13000 GeV-cms, Hadron, mass [jet], 01 natural sciences, high [transverse momentum], W: pair production, Hadron-Hadron scattering (experiments), scattering [p p], Z0: pair production, skin and connective tissue diseases, Z0: hadronic decay, vector boson: associated production, Physics, hadronic decay [Z0], new physics, mass [gauge boson], ATLAS, channel cross section: branching ratio: upper limit, pair production [Z0], CERN LHC Coll, pair production [W], final state: hadronic, lower limit [mass], gauge boson: mass, colliding beams [p p], narrow resonance, Nuclear and High Energy Physics, Particle physics, p p: scattering, mass: lower limit, boosted particle, hadronic [final state], 0103 physical sciences, ddc:530, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, High Energy Physics, structure, 010306 general physics, S056ZOT, hadronic decay [W], W: hadronic decay, branching ratio: upper limit [channel cross section], 010308 nuclear & particles physics, background, S056W1C, jet: mass, Experimental High Energy Physics, lcsh:QC770-798, S071RSG, associated production [vector boson], sense organs, p p: colliding beams, experimental results
Abstract: Journal of high energy physics 2020(6), 42 (1-19) (2020). doi:10.1007/JHEP06(2020)042, Published by SISSA, [Trieste]
Published: 2020
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146. Prostate cancer pathology: What has changed in the last 5 years

Author: Francesco Massari, Rodolfo Montironi, Vincenzo Di Nunno, Marina Scarpelli, Maria Rosaria Raspollini, Alessia Cimadamore, Andrea B. Galosi, Liang Cheng, Antonio Lopez-Beltran, and Andrea Doria
Subjects: Male, Pathology, medicine.medical_specialty, Time Factors, Prostate cancer, classification, clinically significant PCa, grading, staging, 030232 urology & nephrology, Disease, Malignancy, World health, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Grading (tumors), Neoplasm Staging, Cancer staging, business.industry, Consensus conference, Prostatic Neoplasms, General Medicine, medicine.disease, 030220 oncology & carcinogenesis, Neoplasm Grading, Prostate cancer staging, business
Abstract: Prostate cancer is the most frequent non-cutaneous malignancy in men in the United States. In the last few years, many recommendations have been made available from the 2014 International Society of Urologic Pathology consensus conference, 2016 World Health Organization blue book and 2018 8th edition of American Joint Committee on Cancer Staging System. Here, we focus on four topics which are considered relevant on the basis of their common appearance in routine practice, clinical importance and ‘need to improve communication between pathology reports and clinicians’: prostate cancer classification, prostate cancer grading, prostate cancer staging, and current definition of clinically significant prostate cancer. Tissue biomarkers that can predict significant disease and/or upgrading and tissue-based genomics for the purpose of diagnosis and prognosis are mentioned briefly.
Published: 2019
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147. Measurement of prompt photon production in sNN=8.16 TeV p + Pb collisions with ATLAS

Author: Sandra Kortner, Jana Faltova, Alexey Kharlamov, Vadim Kostyukhin, M. Moreno Llácer, Guennadi Borissov, Aliaksei Hrynevich, Francesco Lacava, Athanasios Petridis, Piotr Andrzej Janus, Ivan Yeletskikh, J. T. P. Burr, J. H. N. Rosten, Vincent Kitali, Laura Franconi, Silvia Fracchia, Aziz Chafaq, Antinea Guerguichon, Giulia Ucchielli, M. Tanaka, Y. Benhammou, Ryu Sawada, Juansher Jejelava, Evgueni Ladygin, Keisuke Yoshihara, A. Lösle, Anna Ivina, Ruiqi Zhang, Douglas Schaefer, Francesco Conventi, Maximilian Goblirsch-Kolb, Gabriele Bertoli, Jemal Khubua, Stefania Spagnolo, Daniel Muenstermann, C-Q. Li, Michel Lefebvre, Elliot Reynolds, Stephen Watts, Olivier Arnaez, Edson Carquin, Gabriele Chiodini, Pavel Murin, S. Willocq, Matthew Glenn Kurth, Thibault Guillemin, Caterina Marcon, Catrin Bernius, Umar Gul, Ian Brock, Elliot Lipeles, Saleh Sultansoy, Antonio Salvucci, R. Tanaka, R. Kowalewski, Lukasz Zwalinski, Andreas Reiss, Masahiro Morinaga, Sheena Schier, D. Camarero Munoz, Peter Kodys, Venugopal Ellajosyula, I. Luise, Ehud Duchovni, Silvia Biondi, Alessia Murrone, Peter Buchholz, J. Machado Miguens, George Dyckes, K. F. Di Petrillo, J. L. La Rosa Navarro, Zdenek Dolezal, Mark Sutton, José Salt, Abdeslam Hoummada, Laura Jeanty, Uladzimir Kruchonak, R. W. L. Jones, Cristian Stanescu, Ovsat Abdinov, K. Grimm, A. Seiden, Thomas Malte Spieker, Jan Thomas Kuechler, Ismet Siral, Dimitrios Iliadis, Matthias Saimpert, James Catmore, Sabine Crépé-Renaudin, Artur Trofymov, Ina Carli, Peter Schacht, Soren Stamm, Dimitris Varouchas, Tobias Kupfer, Georgios Zacharis, Alexander Gavrilyuk, Antonio Boveia, Gabriel Palacino, A. T. Doyle, Johannes Balz, Douglas Benjamin, Francesco Maria Follega, Wouter Verkerke, Jesse Heilman, David William Casper, Katsuo Tokushuku, Rhys Edward Owen, Yang Heng, W. Y. Song, Alberto Cervelli, Torre Wenaus, Dominic Hirschbuehl, Srinivasan Rajagopalan, Irene Vichou, Hoang Dai Nghia Nguyen, Hal Evans, Paul Miyagawa, Carlo Alberto Gottardo, Junpei Maeda, K. H. Hiller, Artem Maevskiy, D. Kobayashi, A. C. König, Christopher Blake Martin, Adrian John Bevan, Antonio Giannini, Dale Charles Abbott, R. C. W. Henderson, R. Gupta, M. Kuze, Laura Fabbri, Konstantin Zhukov, Natascha Savic, Jörgen Sjölin, Andre Sopczak, Brian Thomas Amadio, Antonio Miucci, M. J. Shochet, Aimilianos Koulouris, Alexandre Rozanov, T. Kobayashi, Daniel Stefaniak Nielsen, Giorgi Arabidze, A. Ducourthial, T. Ženiš, Janusz Chwastowski, Sharka Todorova-Nova, Fumiya Yamane, Stanislav Suchek, James Frost, Jyoti Prakash Biswal, Tova Ray Holmes, Henrik Oppen, Gunnar Jakel, M. J. 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Strauss, Jared David Little, Oleg Bulekov, Bartosz Sebastian Dziedzic, Lorenzo Massa, Christoph Amelung, F. G. Oakham, Peng Zhang, Kotaro Wakamiya, Benjamin Bordy Tannenwald, Trine Poulsen, P. de Jong, Christopher Samuel Pollard, J. Hrivnac, Alexander David Sherman, Claudio Luci, Maximiliano Sioli, Marco Delmastro, Patrawan Pasuwan, Driss Benchekroun, Fridolin Dittus, Paolo Iengo, Rachel Rosten, Kunihiro Nagano, Fabian Thiele, Miao Liu, Vincenzo Cavasinni, B. Pearson, Aleksandra Dimitrievska, Rosa Simoniello, E. L. Barberio, Katharina Bianca Jakobi, G. H. A. Viehhauser, Tomas Davidek, Sandrine Laplace, Max Fredrik Isacson, Naoki Kimura, Judita Mamuzic, Z. Liang, Z. Wang, John Rutherfoord, Florian Urs Bernlochner, Dwayne Patrick Spiteri, M. Vranjes Milosavljevic, Robert Reed, Michael Düren, I-huan Chiu, T. J. A. Chevalérias, Xiaohu Sun, Diane Cinca, Bin Gui, Tobias Golling, Edoardo Maria Farina, Fernando Barreiro, O. E. Vickey Boeriu, Adam Bailey, Callum Robert Kilby, Eleni Myrto Asimakopoulou, Peter Sherwood, Helmut Wolters, Vladimir Nikolaenko, Y-H. Chen, Robert Les, Oleg Brandt, M. Garcia-Sciveres, Yu Nakahama, Pavel Starovoitov, Bernhard Meirose, Cristiano David Sebastiani, Tomas Kosek, Adam Trzupek, David William Thomas, R. M. Faisca Rodrigues Pereira, Andreas Redelbach, J. E. M. Robinson, Farid Ould-Saada, M. A. B. do Vale, A. A. Affolder, Jack Henry Lindon, Andrew Washbrook, Emilio Higón-Rodriguez, Kevin Black, Lukas Adamek, Hannah Arnold, R. Iuppa, Elodie Deborah Resseguie, David Paul Yallup, Alex Martyniuk, Wolfgang Wagner, Shohei Shirabe, Marie-Hélène Genest, Ivan Pogrebnyak, Y. Delabat Diaz, Anne Marie Sickles, William Keaton Balunas, Tae Hyoun Park, Nabila Wahab Shaikh, Kerstin Lantzsch, Milene Calvetti, Dominique Pallin, Christian Heinz, Antonio Sidoti, Ian Hinchliffe, Shikma Bressler, E. P. Le Quilleuc, Robert Arthur Mina, Alexey Zhemchugov, Dms Sultan, Huan Ren, Matteo Franchini, Ruth Magdalena Jacobs, Alessandro Lapertosa, Elias Ruttinger, Christos Bakalis, Claudia Merlassino, Marco Schioppa, Balazs Konya, S. Kuleshov, J. Chudoba, Katja Hannele Mankinen, Igor Mandić, Thomas Daniel Weston, Yongke Zhao, Ning Zhou, Luigi Longo, Benjamin John Rosser, Donatas Ramilas Zaripovas, C. H. Chen, Andrey Sapronov, Andrea Doria, Nicolas Berger, S. P. Amor Dos Santos, Vincent Garonne, Sandro Palestini, John Kenneth Anders, Nicola Orlando, Trygve Buanes, Andrea Bocci, J. Tanaka, Y. Hernández Jiménez, Apostolos Tsirigotis, D. Levin, Fernando Monticelli, Wenhao Xu, Elena Yatsenko, Peter Krieger, Didier Alexandre, Isabel Nitsche, Brian Le, Ryszard Stroynowski, Karsten Köneke, E. von Toerne, Julien Caudron, Mika Huhtinen, Julien Maurer, Rachid Mazini, Joyful Elma Mdhluli, D. Pohl, M. C. N. Fiolhais, Georges Aad, M. I. Gostkin, David Olivier Jamin, Anna Kathryn Duncan, Bernardo Sotto-Maior Peralva, Jue Chen, H. Meyer Zu Theenhausen, Manuella Vincter, Yoichi Ninomiya, Anna Lipniacka, Bakar Chargeishvili, Ahmed Hasib, Will Davey, Maria Giulia Ratti, A. Pacheco Pages, Nguyen Phuong Dang, Hidetoshi Otono, Gorm Aske Gram Krohn Galster, Diego Casadei, Antonio Ferrer, Carmen Maidantchik, L. Manhaes de Andrade Filho, A. P. Pereira Peixoto, Karola Dette, Wen Yi Song, Chiao-ying Lin, Michal Svatos, Sebastien Prince, Marc Weber, J. M. Iturbe Ponce, A. Sanchez Pineda, G. Rahal, C. Schmitt, Erez Etzion, D. J. A. Antrim, Francois Corriveau, Olympia Dartsi, Elias Coniavitis, Giulio Tiziano Forcolin, Pamela Ferrari, David Robinson, Kunlin Han, Andreas Honle, Valentina Maria Cairo, Kenta Uno, Stefan Kluth, A. L. Lionti, Shlomit Tarem, Nishu Nishu, Gavin Grant Hesketh, Tiesheng Dai, Debarati Roy, Christian Luedtke, Michael James Fenton, Martin Nagel, I. van Vulpen, Rui Zou, Giulio Aielli, Nooshin Dehghanian, Alexey Maslennikov, F. Anulli, Antoine Laudrain, Christopher Grud, Savannah Jennifer Thais, Nora Emilia Pettersson, Margaret Susan Lutz, A. Korn, Gang Zhang, Serkant Ali Cetin, E. Benhar Noccioli, Ariel Schwartzman, Gerhard Ferdinand Rzehorz, Petr Andreevich Gorbounov, Chung-Yau Lo, R. P. Middleton, Rhys Thomas Roberts, Oliver Majersky, Michael William Phipps, Suyog Shrestha, Vasiliki A Mitsou, Nansi Andari, Lianyou Shan, M. Citterio, Richard Nisius, Sune Jakobsen, Giacomo Artoni, Jessica Metcalfe, Melissa Ridel, Deshan Kavishka Abhayasinghe, A. Soloshenko, Thomas Dennis Powell, Reinhard Schwienhorst, Sebastien Rettie, Amal Vaidya, T. M. H. Wolf, Katharina Maria Ecker, Francesco Lanni, Nikolai Fomin, Branislav Ristic, Deepak Kar, Pierfrancesco Butti, Takuya Honda, Salvatore Bruno, Bijan Haney, Ilya Korolkov, H. F.W. Sadrozinski, A. Polini, Cheng-Chieh Peng, Paul Hanke, Elvedin Tahirovic, Stefania Xella, Fr Pastore, Jeanette Lorenz, David Milstead, Jia Jian Teoh, Ahmed Bassalat, Kevin Einsweiler, Ambrosius Thomas Vermeulen, Els Koffeman, Olaf Nackenhorst, Chris Malena Delitzsch, Qing Wang, Krzysztof Woźniak, Ian Michael Snyder, Henri Bachacou, Leonardo Carminati, R. E. Ticse Torres, Jessica Levêque, R. Gamboa Goni, S. Passaggio, Luiz Caloba, Henric George Wilkens, Stefano Manzoni, F. La Ruffa, Sabina Czekierda, Fabio Cerutti, Naoki Ishijima, James Broughton, and Julien Donini
Subjects: Physics, Nuclear and High Energy Physics, Photon, Large Hadron Collider, 010308 nuclear & particles physics, Scattering, Perturbative QCD, Parton, 7. Clean energy, 01 natural sciences, Nuclear physics, Distribution function, Pseudorapidity, 0103 physical sciences, High Energy Physics::Experiment, Rapidity, Nuclear Experiment, 010306 general physics
Abstract: The inclusive production rates of isolated, prompt photons in p+Pb collisions at sNN=8.16 TeV are studied with the ATLAS detector at the Large Hadron Collider using a dataset with an integrated luminosity of 165 nb −1 recorded in 2016. The cross-section and nuclear modification factor RpPb are measured as a function of photon transverse energy from 20 GeV to 550 GeV and in three nucleon–nucleon centre-of-mass pseudorapidity regions, (−2.83,−2.02) , (−1.84,0.91) , and (1.09,1.90) . The cross-section and RpPb values are compared with the results of a next-to-leading-order perturbative QCD calculation, with and without nuclear parton distribution function modifications, and with expectations based on a model of the energy loss of partons prior to the hard scattering. The data disfavour a large amount of energy loss and provide new constraints on the parton densities in nuclei.
Published: 2019
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148. Search for low-mass resonances decaying into two jets and produced in association with a photon using pp collisions at s=13 TeV with the ATLAS detector

Author: R. D. Schamberger, Hanna Maria Borecka-Bielska, Lidia Smirnova, Laurent Chevalier, Pascal Pralavorio, Lamberto Luminari, Tetiana Hryn'ova, Maciej Trzebinski, Ji Zhu, Stuart Derek Walker, Gabriella Sciolla, Louie Corpe, Victor Solovyev, Kerstin Jon-And, Yanjun Tu, Thorwald Klapdor-kleingrothaus, Luca Colasurdo, Kiyotomo Kawagoe, Savanna Marie Shaw, Daniel Guest, Yulia Rodina, Tairan Xu, Fabio Cerutti, Naoki Ishijima, Z. Liang, James Broughton, Julien Donini, D. Pietreanu, Bin Gui, Giuseppe Lerner, Michael Ughetto, Milos Lokajicek, Sandra Kortner, Edoardo Maria Farina, Jana Faltova, J. A. Wilson, M. De Santis, C. A. Solans Sanchez, Alexey Kharlamov, Vadim Kostyukhin, Fernando Barreiro, Stefanie Morgenstern, Shreya Saha, O. E. Vickey Boeriu, Florian Christoph Fischer, Moritz Backes, M. Moreno Llácer, Mariusz Przybycien, Michael Andrew Parker, Tyler James Burch, J. C. Rivera Vergara, Liang Guan, Guennadi Borissov, Aliaksei Hrynevich, Tomas Kosek, Adam Trzupek, Anamika Aggarwal, Andrew Washbrook, Emilio Higón-Rodriguez, Kevin Black, Per Olov Joakim Gradin, J. Jimenez Pena, Jean-Francois Laporte, Francesco Lacava, Athanasios Petridis, Piotr Andrzej Janus, Ivan Yeletskikh, J. T. P. Burr, Calin Alexa, Sofia Chouridou, Jason Nielsen, Grygorii Sokhrannyi, Uta Klein, Maria Smizanska, Andrew Blue, Lidia Dell'Asta, Fabrizio Napolitano, Stephanie Majewski, J. H. N. Rosten, Vincent Kitali, Laura Franconi, Silvia Fracchia, Aziz Chafaq, Antinea Guerguichon, Giulia Ucchielli, M. Tanaka, Y. Benhammou, Ryu Sawada, Juansher Jejelava, Evgueni Ladygin, Keisuke Yoshihara, Y. Delabat Diaz, Anne Marie Sickles, Tae Hyoun Park, Zhidong Zhang, Robert Arthur Mina, Alexey Zhemchugov, Dms Sultan, Rachik Soualah, A. Baroncelli, Baojia Tong, Fabrice Hubaut, Ulrich Parzefall, M. Ziolkowski, Scott Snyder, Tigran Mkrtchyan, Isabelle Wingerter-Seez, A. Lösle, Alessandro Tricoli, Stefan Guindon, Simone Michele Mazza, Christopher Lester, Remi Zaidan, Michel Raymond, Bruce Schumm, Charles Delporte, Leonardo Merola, Wladyslaw Dabrowski, Huan Ren, J. Chudoba, Katja Hannele Mankinen, Brian Moser, Carlos Lacasta, Masaya Ishino, Anna Ivina, Andrew White, Matthew John Baca, Ruiqi Zhang, Eleni Skorda, Dengfeng Zhang, Igor Mandić, Thomas Daniel Weston, Yongke Zhao, Ning Zhou, Donatas Ramilas Zaripovas, C. H. Chen, Andrey Sapronov, Nicolas Berger, Chris Sander, Anna Shcherbakova, S. Stärz, M. Alvarez Estevez, Evelin Meoni, Lorenzo Rossini, Aytul Adiguzel, Dmitri Tsybychev, Ivan Angelozzi, Stefan Stonjek, S. P. Amor Dos Santos, Shunsuke Adachi, Fernando Monticelli, Wenhao Xu, Elena Yatsenko, R. Goncalves Gama, Peter Krieger, S. Tapia Araya, Yasuyuki Okumura, Mark Hodgkinson, Andrej Filipcic, Lydia Roos, Yi-Tao Wang, Kim Katrin Heidegger, Ariella Cattai, Simon Berlendis, Davide Caforio, Yona Oren, D. M. 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Middleton, Rhys Thomas Roberts, Bo Li, Sally Seidel, Ryan Christopher Edgar, Leonardo Paolo Rossi, Till Eifert, K. Al Khoury, Abner Soffer, Lily Asquith, Marco Milesi, Jianming Qian, Shyam Balaji, Tony Kwan, Yiming Abulaiti, M. Cano Bret, Thomas Trefzger, Daniel Scheirich, Runyu Bi, Carsten Dulsen, James Shank, Christian Weiser, S. Ketabchi Haghighat, E. V. Bouhova-Thacker, M. U. F Martensson, Seyed Ruhollah Shojaii, Barbara Liberti, Amy Selvi Tee, C. Bourdarios, Jens Weingarten, Robert Wolff, Andrew Stuart Bell, Patrick Bryant, Nadav Michael Tamir, Elizaveta Shabalina, Harry James Moss, Sanmay Ganguly, Timothy Andeen, Adam Maxwell Azoulay, Flera Rizatdinova, Andrey Soukharev, A. Nag Nag, Vanja Morisbak, Nacim Haddad, A. S. Kozhin, Russell James Turner, John Derek Chapman, Xanthe Hoad, Laurie Iain McClymont, W. Kozanecki, Emre Celebi, S. Timoshenko, Koki Maekawa, Tony Liss, Anjali Krishnan, Helena Santos, Timon Heim, D. Rodriguez Rodriguez, Bertrand Laforge, Knut Zoch, Carl Gwilliam, Andreas Sogaard, Shi Che, Marcella Capua, Katharina Becker, Alice Alfonsi, M. H. Klein, Paolo Calafiura, Alexander Solodkov, Yun-Ju Lu, Lauren Tompkins, Kevin Daniel Finelli, Else Lytken, Mason Proffitt, L. Barranco Navarro, Y. Huang, Irena Nikolic-Audit, G. Otero y Garzon, A. S. White, Konstantin Vorobev, Lukas Heinrich, Sofia Adorni, David South, I. Lopez Paz, Andrea Ventura, Ben Carlson, Evangelos Kourlitis, Speranza Falciano, Ioannis Maznas, B. L. Liu, K. A. Johns, Pingchuan Zhao, Zuzana Barnovska-Blenessy, Thomas Daubney, Evgeniya Cheremushkina, David Michael Handl, Yi Chen, Tae Min Hong, Teresa Lenz, A. R. Weidberg, P. A. Bruckman de Renstrom, R. Bartoldus, Chen Zhou, N. D. Dann, J. J. Lozano Bahilo, Jing Guo, Asma Hadef, George Redlinger, Christian Johann Riegel, M. De Beurs, Huacheng Cai, Reiner Hauser, Eirik Gramstad, Nils Krumnack, Thu Pham, Kouta Onogi, T. P. A. Åkesson, Jared Gregory Vasquez, Anthony Keith Morley, Peter Wagner, Wasikul Islam, Mikhail Mineev, Jozsef Toth, Elena Korolkova, Carla Sbarra, Bruce Gallop, Diallo Boye, Manuel Neumann, Paris Moschovakos, Markus Wobisch, Masahiro Ikeno, Stefano Zambito, Lotte Ansgaard Thomsen, H. T. Li, Ferdinand Schenck, Tobias Bisanz, Tadej Novak, Remco Castelijn, D. P. C. Sankey, Bojan Hiti, S. H. Robertson, Andrea Dell'Acqua, Tim Jones, Giuseppe Mornacchi, Joao Saraiva, Otilia Anamaria Ducu, S. L. Lloyd, Elham E Khoda, O. Bessidskaia Bylund, Danijela Bogavac, Aaron Angerami, Alejandro Alonso, Wainer Vandelli, T. Geralis, W. Buttinger, C. J. S. Young, Masato Aoki, Junya Usui, Markus Elsing, Lee Sawyer, Adam Jackson Parker, Andreas Hoecker, Atsushi Mizukami, Benjamin Henry Hooberman, Alessandra Betti, Mateusz Dyndal, Jeffrey Rogers Dandoy, Harald Joerg Stelzer, Massimo Antonelli, Yorihito Sugaya, B. Di Micco, N. Lorenzo Martinez, Alexander Bogdanchikov, Ewelina Lobodzinska, H. B. Liu, Shaun Roe, X. Y. Zhang, S. Tzamarias, J. Urban, Nicolo Magini, G. Usai, Olga Rezanova, Samuel Calvet, Simonetta Gentile, Ben William Whitmore, Masaki Ishitsuka, N. Benekos, Igor Aleksandrov, Miha Muskinja, J. B. Liu, R. F. Naranjo Garcia, Shan Jin, Farida Fassi, Denis Salihagic, Sandra Leone, Gregor Gessner, Y. Wu, Magnar Kopangen Bugge, Andreas Salzburger, M. Shimojima, Marek Palka, Lorenzo Rinaldi, Bartlomiej Zabinski, Krzysztof Korcyl, Jihyun Jeong, Stan Bentvelsen, J. C. Vermeulen, Lydia Beresford, Eric Edward Corrigan, Philip Patrick Allport, Mohammed Ezzi, R. Röhrig, Christoph Rembser, Etienne Dreyer, A. A. Minaenko, Andreas Warburton, G. Calderini, M. Villaplana Perez, Iro Koletsou, Grigore Tarna, Konstantin Lehmann, K. K. Gan, Brian Petersen, Namig Javadov, Tamar Djobava, Ivor Fleck, Sinan Kuday, A. M. Rodríguez Vera, Florian Bauer, R. Camacho Toro, Mariyan Petrov, L. F. Oleiro Seabra, Adrian Chitan, Benjamin Wynne, Patrick Czodrowski, A. De Salvo, Radek Novotny, Koji Terashi, Craig Buttar, M-S. Barisits, Joleen Pater, N. Viaux Maira, Michele Livan, Q. J. Li, Ioulian Budagov, Annick Lleres, Gino Marceca, K. Potamianos, Makoto Tomoto, D. J. Lewis, Timothy Barklow, Daria Zieminska, C. A. Chavez Barajas, Sebastian Liem, P. C. F. Glaysher, Andrei Snesarev, Elena Murielle Freundlich, Ahmimed Ouraou, Alessandro Ambler, Heberth Torres, Takuya Tashiro, D. della Volpe, David Richard Shope, Alan Litke, Mieczyslaw Witold Krasny, Juan Pedro Araque, Friedrich Hoenig, J. S. Lange, Giancarlo Panizzo, Zhi Zheng, L. K. Gladilin, Eduard Kladiva, Mjr Olsson, L. Aperio Bella, A. Farilla, Pedro Teixeira-Dias, J.-H. Arling, Davide Gerbaudo, Andrzej Smykiewicz, Peter Bussey, Y. Unno, Theodor Christian Herwig, Marzio Nessi, Jeremy Love, Kendall Reeves, R. M. D. Carney, Jens Janssen, Pavel Staroba, Minyu Feng, Marta Maria Perego, Matthew James Sullivan, Mariel Nelson Pettee, Sarah Demers, Gaetano Barone, Emery Nibigira, Francesco Gonnella, Mark Neubauer, Frued Erik Braren, P. U. E. Onyisi, Sarah Louise Barnes, John Stupak, Tomas Blazek, Salah-eddine Dahbi, G. Eigen, Hicham Atmani, Mirta Dumancic, F. Safai Tehrani, Manuel Patrice Geisler, A. Tarek Abouelfadl Mohamed, Jiri Hejbal, Vadim Bednyakov, Laurelle Maria Veloce, Ryuichi Takashima, Ettore Zaffaroni, Alexander Armstrong, Simon Schmitz, Marcello Bindi, Matteo Scornajenghi, Andreas Christian Dudder, Saskia Falke, Xuan Yang, Panagiotis Bellos, Petr Tas, S. H. Oh, Dirk Zerwas, Laura Gonella, Stefano Veneziano, Mihail Chizhov, Bruno Mansoulie, Daniel Mauricio Rauch, M. P. Giordani, Chilufya Mwewa, Paul Newman, D. Xu, Alexei Klimentov, Daniel Mori, F. M. Giorgi, S. P. Mc Kee, Lorenzo Paolozzi, S. Heim, J. L. Munoz Martinez, Anton Wolf, D. Berge, Luc Goossens, Natalia Korotkova, Daniela Rebuzzi, Itsuo Nakano, P. Puzo, Harald Fox, Lashkar Kashif, Khalil Bouaouda, J. R. Bensinger, Sophio Pataraia, Stylianos Angelidakis, Iain Alexander Bertram, Elisa Fumagalli, Ladislav Chytka, Vassili Kazanin, Tobias Klingl, Michael Holzbock, Michael Rijssenbeek, Ivana Hristova, Edisher Tskhadadze, Andre Rummler, Juan Terron, Frederic Schroeder, Xiaocong Ai, Fang-ying Tsai, Simone Monzani, Chiara Debenedetti, S. González de la Hoz, Bernard Brickwedde, Jean-Francois Grivaz, M. Beretta, Xiao-yan Li, Thomas Naumann, Saminder Dhaliwal, Riccardo-Maria Bianchi, Joseph Izen, Ruslan Mashinistov, Quentin Buat, Alessandra Ciocio, K. Sliwa, Kurt Keys Hill, Stephanie Zimmermann, Christos Vergis, Dewen Zhong, Thomas James Stevenson, Sophie Trincaz-Duvoid, Kazuhiko Hara, Irina Antonela Cioara, Giordon Holtsberg Stark, Daniela Salvatore, J. Griffiths, Kosuke Takeda, Darren Price, Fedor Prokoshin, Pierre Savard, Paul Fraser Harrison, D. Oliveira Damazio, Matthew Craig Mondragon, David Cameron, Giulia Ripellino, Julian Constantin Schmoeckel, Tomasz Bold, R. M. Barnett, S. Y. Suzuki, S. J. Chen, Albert Francis Casha, Robert Stanek, J. Huston, Souad Batlamous, A. N. Karyukhin, T. R. Van Daalen, Chrysostomos Valderanis, Yohei Yamaguchi, Helge Christoph Beck, Oxana Smirnova, and Konstantinos Bachas
Subjects: Physics, Nuclear and High Energy Physics, Photon, Large Hadron Collider, 010308 nuclear & particles physics, Atlas detector, Atlas (topology), ATLAS experiment, 7. Clean energy, 01 natural sciences, Nuclear physics, Transverse plane, 0103 physical sciences, High Energy Physics::Experiment, 010306 general physics, Low Mass
Abstract: A search is performed for localised excesses in dijet mass distributions of low-dijet-mass events produced in association with a high transverse energy photon. The search uses up to 79.8 fb−1 of LHC proton–proton collisions collected by the ATLAS experiment at a centre-of-mass energy of 13 TeV during 2015–2017. Two variants are presented: one which makes no jet flavour requirements and one which requires both jets to be tagged as b-jets. The observed mass distributions are consistent with multi-jet processes in the Standard Model. The data are used to set upper limits on the production cross-section for a benchmark Z′ model and, separately, on generic Gaussian-shape contributions to the mass distributions, extending the current ATLAS constraints on dijet resonances to the mass range between 225 and 1100 GeV.
Published: 2019
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149. Quantification of Pediatric Burn Scar Stiffness Using Acoustic Radiation Force Impulse Ultrasound Elastography

Author: Joel S. Fish, Jennifer Zuccaro, Manuela M. Perez, Arun Mohanta, and Andrea Doria
Subjects: Male, Acoustics and Ultrasonics, Biophysics, Impulse (physics), Cicatrix, 03 medical and health sciences, Hypertrophic scar, 0302 clinical medicine, Elastic Modulus, Ultrasound elastography, medicine, Humans, Radiology, Nuclear Medicine and imaging, Longitudinal Studies, Child, Acoustic radiation force, Acoustic radiation force impulse imaging, 030203 arthritis & rheumatology, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Ultrasound, Infant, Stiffness, 030208 emergency & critical care medicine, Acoustics, medicine.disease, Child, Preschool, Elasticity Imaging Techniques, Female, Elastography, medicine.symptom, Burns, business, Biomedical engineering
Abstract: The purpose of this study was to quantify the stiffness of hypertrophic scars using acoustic radiation force impulse ultrasound elastography. Sixteen pediatric patients with hypertrophic scars resulting from burn injuries participated in this study (mean age: 5.13, standard deviation: 3.20). Values for the elastic modulus (E) of scar and control sites were obtained. Scarred areas were found to be almost four times stiffer than control sites (scar Emean = 39.29 kPa compared with control Emean = 10.19 kPa) (p = 0.0004). Correlations between scar stiffness and clinician-reported subjective scar scale scores were not observed (rs = 0.30, p = 0.27 and rs = 0.25, p = 0.35 respectively). We found that acoustic radiation force impulse imaging can discriminate between hypertrophic scars and normal skin and should be considered a potentially valuable tool in the armamentarium of objective scar measures. Future research should focus on evaluating the technology's ability to detect scar change over time in order to determine responsiveness to treatment.
Published: 2019
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150. Search for invisible Higgs boson decays in vector boson fusion at s=13TeV with the ATLAS detector

Author: M. De Beurs, Huacheng Cai, Nabila Wahab Shaikh, Kerstin Lantzsch, Milene Calvetti, G. Lehmann Miotto, C. M. Vergel Infante, Kerim Suruliz, Monika Wielers, C. F. Feng, Adam Edward Barton, Li Zhou, Eric Lancon, Z. Liang, Bin Gui, Edoardo Maria Farina, Fernando Barreiro, O. E. Vickey Boeriu, Tomas Kosek, Dominique Pallin, Christos Bakalis, Pienpen Seema, Marco Schioppa, H. Zhu, Michael Huebner, Reiner Hauser, Bruce Gallop, Manuel Neumann, Givi Sekhniaidze, Juraj Smiesko, A. Di Simone, Clement Camincher, Felix Cormier, H. Kagan, Domizia Orestano, Semen Turchikhin, Till Eifert, Christopher Anelli, Ian Connelly, L. Pacheco Rodriguez, Richard Bates, Vincent Garonne, Sandro Palestini, John Kenneth Anders, Nicola Orlando, Andrea Bocci, Luca Colasurdo, Ossama AbouZeid, Stefanie Morgenstern, Moritz Backes, Sofia Chouridou, Mohamed Ouchrif, Christopher Willis, Silvia Franchino, A. De Santo, Stephen Hillier, M.A. Haleem, Luis Hervas, Aaron Angerami, Alejandro Alonso, Adam Trzupek, Andrew Washbrook, Emilio Higón-Rodriguez, Kevin Black, Y. Delabat Diaz, Anne Marie Sickles, Abner Soffer, Isabel Nitsche, Jason Nielsen, Brian Le, Steffen Stärz, Ryszard Stroynowski, Grygorii Sokhrannyi, Uta Klein, Maria Smizanska, Markus Elsing, Lee Sawyer, Birgit Sylvia Stapf, Vit Vorobel, Carsten Bittrich, Martin Rybar, Lily Asquith, F. S. Merritt, Marco Milesi, Tomoya Iizawa, Lydia Brenner, C-Q. Li, William Keaton Balunas, E. P. Le Quilleuc, Alison Elliot, Michel Raymond, Bruce Schumm, Charles Delporte, Leonardo Merola, Ahmed Hasib, Adam Jackson Parker, Aytul Adiguzel, Dmitri Tsybychev, Hans Peter Beck, Chao Wang, Andreas Honle, Valentina Maria Cairo, Kim Katrin Heidegger, M. I. Gostkin, G. Rybkin, M. Stegler, Alexey Zhemchugov, Dms Sultan, Tony Kwan, Andreas Hoecker, Atsushi Mizukami, Benjamin Henry Hooberman, Jeffrey Rogers Dandoy, Dalila Salamani, Thomas LeCompte, D. Boscherini, Thomas Philippe Calvet, Huan Ren, Harald Joerg Stelzer, B. Martin dit Latour, Claudia Merlassino, O. Le Dortz, Liang Li, Francois Vazeille, Tina Sfiligoj, E. Benhar Noccioli, Ariel Schwartzman, Petr Andreevich Gorbounov, Chung-Yau Lo, J. Chudoba, Katja Hannele Mankinen, Igor Mandić, Thomas Daniel Weston, Yongke Zhao, Ning Zhou, Donatas Ramilas Zaripovas, C. H. Chen, Saverio D'Auria, Sabrina Sacerdoti, C. P. Ward, Yohei Noguchi, Tamsin Nooney, Ewan Hill, Michel Lefebvre, E. S. Kuwertz, Elliot Reynolds, Oliver Stelzer-Chilton, L. Feremenga, A. Sanchez Pineda, G. Rahal, Tim Scanlon, Balazs Konya, Edson Carquin, Oliver James Winston, A. S. Thompson, Massimo Antonelli, Benedict Tobias Winter, G. Usai, Benedetto Giacobbe, Yongsun Kim, Gilberto Giugliarelli, Christian Weber, Gabriele Chiodini, Pavel Murin, S. Willocq, Matthew Glenn Kurth, Yahya Tayalati, Andrey Sapronov, Nicolas Berger, S. P. Amor Dos Santos, Nansi Andari, Lianyou Shan, Richard Nisius, Melissa Ridel, Deshan Kavishka Abhayasinghe, Milena Bajic, Takashi Kubota, Andrey Kiryunin, Raphael Vuillermet, Martina Javurkova, Masaki Ishitsuka, N. Benekos, Markus Nordberg, Claudia Glasman, Vakhtang Tsiskaridze, J. N. Butler, Anyes Taffard, You Zhou, Heather Lynn Russell, H. De la Torre, Simone Amoroso, Baptiste Abeloos, Amy Selvi Tee, Sebastien Rettie, Amal Vaidya, Francesco Lanni, Nikolai Fomin, Peter Nemethy, Fernando Monticelli, Wenhao Xu, Elena Yatsenko, C. Bourdarios, Jens Weingarten, Robert Wolff, Peter Krieger, Mika Huhtinen, Julien Maurer, Elisabeth Schopf, Olga Igonkina, Tony Liss, Bijan Haney, Ilya Korolkov, David Olivier Jamin, Anna Kathryn Duncan, Sarah Jones, James Walder, Yoshiji Yasu, A. Andreazza, Yoram Rozen, Robert Leone, F. Luehring, O. Estrada Pastor, Pamela Ferrari, Sw. Banerjee, Suyog Shrestha, Farida Fassi, Trygve Buanes, J. Tanaka, Y. Hernández Jiménez, Marco Fraternali, Thibault Guillemin, Umar Gul, John Morris, Louise Heelan, Denis Salihagic, Silvia Resconi, Mazuza Ghneimat, M. Shimojima, Zvi Hirsh Citron, Bartlomiej Zabinski, Krzysztof Korcyl, Jihyun Jeong, Emily Claire Orgill, Stan Bentvelsen, J. C. Vermeulen, Tim Adye, Verena Maria Walbrecht, R. D. Kass, Zdenek Hubacek, Vasiliki A Mitsou, Dmitriy Maximov, D. Levin, Karsten Köneke, E. von Toerne, Ian Brock, R. Kowalewski, Lukasz Zwalinski, Andreas Reiss, Bernardo Sotto-Maior Peralva, Jue Chen, H. Meyer Zu Theenhausen, Manuella Vincter, Kilian Rosbach, Gabriela Navarro, Veronica Fabiani, Daniel Froidevaux, Fabio Tresoldi, C. S. Rogan, James Mueller, Lydia Beresford, Nicolas Ellis, Alexander Melzer, Alan James Taylor, Philip Phillips, Samuel Silverstein, Chav Chhiv Chau, H. F.W. Sadrozinski, Hajime Nanjo, H. H. Williams, Giada Mancini, A. Bethani, Andreas Wildauer, Knut Zoch, Andrzej Olszewski, Giorgio Chiarelli, Lingshan Xu, Julien Caudron, Yoichi Ninomiya, Anna Lipniacka, Sebastien Prince, Marc Weber, J. M. Iturbe Ponce, A. Tavares Delgado, Davide Costanzo, J-P. Meyer, Lucio Cerrito, Peng Huo, Lara Hannan Mason, Corentin Allaire, Michal Simon, Steinar Stapnes, Ludovico Pontecorvo, Carl Gwilliam, Paolo Calafiura, Alexander Solodkov, Yun-Ju Lu, Lauren Tompkins, Kevin Daniel Finelli, Rachid Mazini, Joyful Elma Mdhluli, William Mickael Barbe, Xiang Li, Polina Nechaeva, A. Borisov, Masahiro Morinaga, Peilian Liu, D. I. Narrias Villar, M. El Kacimi, Akira Yamamoto, Harish Potti, Yee Chinn Yap, Josh Moss, Enrique Kajomovitz, D. Pohl, M. C. N. Fiolhais, Georges Aad, Giovanni Siragusa, Sarah Kate Boutle, Branislav Ristic, Andreas Warburton, Deepak Kar, G. Calderini, Carmen García, Sheena Schier, Peter Kodys, Kerry Ann Parker, Balthasar Maria Schachtner, Tulin Varol, A. Polini, Venugopal Ellajosyula, Silvia Biondi, Alessia Murrone, Peter Buchholz, K. F. Di Petrillo, M. Villaplana Perez, Iro Koletsou, J. L. La Rosa Navarro, Zdenek Dolezal, Mark Sutton, José Salt, Abdeslam Hoummada, Irena Nikolic-Audit, G. Otero y Garzon, A. S. White, Konstantin Vorobev, Mark Stockton, Yoichi Ikegami, Daniel Andreas Britzger, Marco Battaglia, L. La Rotonda, T. Dias Do Vale, Xi Chen, Theodoros Alexopoulos, Will Davey, I. Turk Cakir, Maria Giulia Ratti, F. A. Jimenez Morales, Miroslav Hrabovsky, G. Bernardi, Kazunori Hanagaki, Benjamin Philip Nachman, Rotem Barnea, Iurii Naryshkin, A. C. Schaffer, Matthias Schott, Maximilian Swiatlowski, C. Haber, Hai Jiang, Junichi Kanzaki, Sabrina Perrella, M. V. Silva Oliveira, Evgenii Baldin, Louis Helary, Anna Mastroberardino, Bruno Lenzi, David Kirchmeier, Maximilian Hils, Alexey Buzykaev, D. Rousseau, Lukas Heinrich, Joao Seixas, S. M. Weber, Tomáš Javůrek, Martin Tripiana, Steffen Schmitt, D. Zhang, Miha Zgubic, Cherifa Sabrina Amrouche, Antonio Ereditato, Mauro Citterio, Tigran Mkrtchyan, Stefania Xella, Guillermo Nicolas Hamity, Alessandro Calandri, Vincent Croft, David South, Hiroyuki Iwasaki, John-Bjarne Hansen, Fr Pastore, Evangelos Kourlitis, Isabelle Wingerter-Seez, Alessandro Tricoli, E. Le Guirriec, Emmerich Kneringer, Donatella Cavalli, U. Mallik, Stefan Guindon, Simone Michele Mazza, Ioannis Maznas, B. L. Liu, K. A. Johns, Pingchuan Zhao, Clement Helsens, David Michael Handl, H. Ten Kate, A. Pacheco Pages, Nguyen Phuong Dang, Hidetoshi Otono, Antonio Ferrer, Carmen Maidantchik, L. Manhaes de Andrade Filho, A. P. Pereira Peixoto, Simona Serena Bocchetta, Petr Sicho, Y. S. Ng, C. A. Lee, T. Kono, Antoine Laudrain, Miroslav Myska, Blake Burghgrave, James Pinfold, Tomas Dado, Christopher Grud, R. S. P. Mueller, Louis Fayard, Savannah Jennifer Thais, Nora Emilia Pettersson, Margaret Susan Lutz, A. Korn, Oliver Majersky, Laura Jeanty, Christopher Lester, Jeanette Lorenz, David Milstead, Jia Jian Teoh, Remi Zaidan, Ahmed Bassalat, Kevin Einsweiler, Ambrosius Thomas Vermeulen, Yi Chen, Tae Min Hong, Teresa Lenz, A. R. Weidberg, P. A. Bruckman de Renstrom, Uladzimir Kruchonak, Cristian Stanescu, Ovsat Abdinov, K. Grimm, Adelina D'onofrio, Toshiaki Kaji, B. M. Waugh, Claire Antel, D. Golubkov, Daniel Turgeman, Magnar Kopangen Bugge, Andrea Messina, Aidan Robson, D. P. Benjamin, Joachim Heinrich, Grazia Cabras, P. Morettini, Grigore Tarna, Jianqiao Ye, Marco Lavorgna, Frederic Deliot, David Salek, Jacob Henry Rawling, C. Di Donato, Horst Oberlack, A. Di Girolamo, Mario Campanelli, Colleen Jennifer Treado, Harinder Singh Bawa, Oliver Kortner, Vakhtang Tsulaia, Michal Suk, Pavel Podberezko, Katherine Pachal, James Monk, Charles Leggett, Fabian Huegging, Katharina Bierwagen, Brigitte Vachon, Arthur Eugen Bolz, Andrew White, Giulio Cornelio Grossi, Matthew John Baca, Ariella Cattai, Abigail Alexandra O'Rourke, Katharina Schleicher, W. D. Breaden Madden, Ismet Siral, Dimitrios Iliadis, Nikolina Ilic, Francesco Spanò, Jared David Little, Oleg Bulekov, Bartosz Sebastian Dziedzic, Mark Slater, A. M. Zaitsev, D. Chakraborty, Michael Schernau, Jorge Duarte-Campderros, Lorenzo Massa, Christoph Amelung, F. G. Oakham, Benjamin Bordy Tannenwald, Fabian Alexander Förster, Vadim Gratchev, Rute Pedro, Xuai Zhuang, Samira Hassani, Borut Paul Kerševan, C. Da Via, K. K. Gan, Brian Petersen, D. P. J. Lack, Pavol Strizenec, Maddalena Giulini, Siegfried Wenig, Paolo Iengo, Rachel Rosten, G. A. 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Long, Giuseppe Iacobucci, Theodoros Georgio Zorbas, Arely Cortes-Gonzalez, Thomas Koffas, Alexander Milov, Christian Gumpert, Benjamin Trocmé, M. T. Dova, Bengt Lund-Jensen, Francesco Gonnella, Valerio Bortolotto, C. J. E. Suster, Steven Goldfarb, Z. G. Zhao, Mark Neubauer, Susumu Oda, J. S. Keller, Aaron Foley Webb, Alexi Gongadze, Giovanni Darbo, Marianna Testa, Holly Ann Pacey, Frued Erik Braren, Graeme Stewart, Mattias Ellert, M. Losada, P. M. Tuts, Michael Begel, Lene Bryngemark, Gianluca Alimonti, Rainer Stamen, Franziska Iltzsche, Jacob Julian Kempster, Christos Anastopoulos, Bianca Osculati, Frank Ellinghaus, P. U. E. Onyisi, Claire Gwenlan, Marina Rotaru, Ishan Pokharel, H. van der Graaf, Athanasios Manousos, Ajit S. Puri, Sarah Louise Barnes, Xin Wu, John Stupak, Minoru Hirose, Zara Jane Grout, Viktor Kramarenko, G. N. Taylor, Tomas Blazek, Antonio Sbrizzi, Salah-eddine Dahbi, Konstantinos Papageorgiou, Benjamin Brau, Nazim Huseynov, Francisco Anuar Arduh, Jaroslava Schovancova, Wenge Wang, E. Thomson, Ofir Gabizon, Matteo Negrini, A. Coccaro, S. Rodriguez Bosca, Seppe Kuehn, Benjamin Weinert, Michael Dührssen, Arabinda Behera, Troels Petersen, Eric Buschmann, G. Eigen, Mirta Dumancic, F. Safai Tehrani, Manuel Patrice Geisler, A. Tarek Abouelfadl Mohamed, Jiri Hejbal, Vadim Bednyakov, Laura Perini, Ziyu Guo, J. A. Valls Ferrer, M. L. Kocian, Nikolaos Rompotis, Ruth Poettgen, Mark Andrew Pickering, Simon Feigl, Paolo Bagnaia, Antoine Marzin, Fabian-Phillipp Tepel, Laurelle Maria Veloce, Gen Kawamura, Ryuichi Takashima, Ettore Zaffaroni, Alexander Armstrong, Simon Schmitz, Enrico Pasqualucci, Roberto Ferrari, Anna Sfyrla, T. Theveneaux-Pelzer, Matthew Gignac, Samuel Joseph Crawley, Yuya Kano, Paola Giannetti, Marcello Bindi, Matteo Scornajenghi, K. De Vasconcelos Corga, Ayda Beddall, Andrea Gaudiello, Ryan Reece, Andreas Christian Dudder, Panagiotis Bellos, Petr Tas, S. H. Oh, Laura Gonella, Andrej Gorišek, Stefano Veneziano, Y. M. Ma, Craig Blocker, Gregor Herten, Miriam Lucio Martinez, V. I. Martinez Outschoorn, Snezana Nektarijevic, M. Wu, Frank Filthaut, Anne-Isabelle Etienvre, Pavel Reznicek, Daniel Mauricio Rauch, M. P. Giordani, Z. Marshall, Bruce Yabsley, Kazuki Yajima, Beojan Stanislaus, Satoshi Higashino, Alessandra Camplani, Chilufya Mwewa, Daniel Mori, F. M. Giorgi, Elzbieta Banas, Alexandra Schulte, Ligang Xia, Ryunosuke Iguchi, Stefan Simion, Peter Kluit, J. D. Bossio Sola, J. E. Pilcher, Matteo Cavalli-Sforza, Alevtina Shmeleva, S. P. Mc Kee, Lorenzo Paolozzi, S. Heim, Luc Goossens, Daniela Rebuzzi, Itsuo Nakano, Harald Fox, Lashkar Kashif, Khalil Bouaouda, J. R. Bensinger, Rose Elisabeth Ardell, Sophio Pataraia, Stylianos Angelidakis, Ladislav Chytka, Vassili Kazanin, Michael Holzbock, Davide Melini, Samina Jabbar, Ivana Hristova, Edisher Tskhadadze, Mirkoantonio Casolino, M. Faucci Giannelli, Jonathan Crane, Karol Krizka, Stefan Gadatsch, Mathis Kolb, Eftychia Tzovara, Stephen Sekula, Xifeng Ruan, Christopher Hayes, Sara Alderweireldt, K. J. C. Leney, A. M. Cooper-Sarkar, Stefano Camarda, Jennifer Kathryn Roloff, Rinat Fakhrutdinov, Frederick Dallaire, Nicolo Vladi Biesuz, Alexander Law, Elena Rocco, S. Campana, Annabelle Julia Chuinard, Silvia Fressard-Batraneanu, Christophe Clement, Rosy Nicolaidou, Vincenzo Canale, K. H. Hiller, R. C. W. Henderson, M. J. Shochet, Aimilianos Koulouris, Alexandre Rozanov, T. Kobayashi, Claudio Santoni, Stephen Jiggins, Giordon Stark, Pavel Shatalov, Jochen Dingfelder, Alex Kastanas, Alaettin Serhan Mete, Chaowaroj Wanotayaroj, Nima Sherafati, David Calvet, David Sosa, Gregory David Hallewell, Jiri Dolejsi, P. T. E. Taylor, Alastair Dewhurst, Heinz Pernegger, Alexander Oh, P. K. Teng, Hisaya Kurashige, R. El Kosseifi, H. L. Zhu, Ryo Tanioka, Cesare Bini, Zhen Yan, Michael Kagan, Rodney Walker, David Robert Wardrope, Sergey Senkin, Bo Liu, Veysi Erkcan Ozcan, Alberto Mengarelli, P. D. Thompson, Jonathan Long, Efe Yigitbasi, S. A. Olivares Pino, Josh Mcfayden, Andrew Pilkington, Vitaliano Chiarella, Bobby Samir Acharya, H. A. Neal, Andrey Ryzhov, Guillaume Unal, A. Artamonov, Daniela Bortoletto, Nello Bruscino, Robert Adam Vallance, Evgeny Starchenko, C. Padilla Aranda, Mathieu Benoit, Jason Dhia Mansour, Yuji Yamazaki, Lewis James Armitage, Jinhong Yu, Veronika Magerl, Alexander Undrus, Calum Michael Macdonald, Steven Patrick Alkire, Simon Henry Connell, Tatsuya Masubuchi, Oliver Keith Baker, Jiri Kvita, Lucas Macrorie Flores, Francesco Crescioli, Victoria Jane Martin, Cecile Deterre, John Alison, Sara Valentinetti, Frank Winklmeier, L. R. Flores Castillo, Emily Charlotte Graham, Luc Poggioli, Christine Kourkoumelis, Pedro Jorge, Gvantsa Mchedlidze, H. J. Cheng, Mauro Iodice, Lingxin Meng, Yanyan Du, Ruggero Turra, Maia Mosidze, Antonio Policicchio, Markus Atkinson, Graham Richard Lee, Y. Guo, Stephen Kam-wah Chan, Werner Spolidoro Freund, Louis Guillaume Gagnon, Zachary Alden Meadows, Richard Polifka, S.-C. Hsu, Marcin Wladyslaw Wolter, Aparajita Dattagupta, Alexander Grillo, Robert McPherson, C. Petridou, Vivek Jain, Angel Campoverde, V. W. S. Wong, B. Stugu, Nigel Hessey, Marija Marjanovic, Ricardo Gonçalo, Fabrizio Fabbri, Mingliang Zhou, Timo Dreyer, Ana Elena Dumitriu, G. Marchiori, Alexander Khanov, Alexander Naip Tuna, Duc Ta, Ahmet Bingul, Elzbieta Richter-Was, Meghan Frate, Ryan White, Michal Marcisovsky, Adam James Bozson, Martin Aleksa, Marta Lidia Rimoldi, Regina Moles-Valls, Jan-Ulf Mjörnmark, Giuliano Gustavino, Malcolm Bruce Skinner, Ruchika Nayyar, Ulrike Blumenschein, Oleh Kivernyk, Tadashi Maeno, T. Nguyen Manh, Stéphane Jézéquel, Saime Gurbuz, S. E. von Buddenbrock, Alexey Dudarev, Philippe Grenier, Brad Abbott, Korbinian Ralf Schmidt-Sommerfeld, Maarten Boonekamp, Pierre Petroff, Viviana Cavaliere, William James Fawcett, I. Ravinovich, Tatsumi Nitta, Christos Gentsos, Vasiliki Kouskoura, Emma Winkels, J. P. Thomas, Chiara Rizzi, Dusan Bruncko, Jason Veatch, Elena Plotnikova, A. J. Lankford, L. Han, Geoffrey Henry Herbert, Vasilis Konstantinides, Eda Yildirim, Marcella Bona, Abdenour Lounis, Saskia Falke, Dirk Zerwas, Nathalie Besson, Yu Him Justin Chiu, Laura Brittany Havener, S. Cabrera Urbán, B. H. Brunt, Josef Pacalt, D. M. Gingrich, Dingane Reward Hlaluku, J. Glatzer, Enrico Rossi, Chase Owen Shimmin, Kristina Anne Looper, Cora Fischer, Mihail Chizhov, Deywis Moreno, Francesco Nuti, Bruno Mansoulie, Paul Newman, S. Malyukov, Christian Gutschow, Kurt Brendlinger, Serban Constantinescu, Adele Rimoldi, A. P. Colijn, Terutaro Nakamura, G. A. Cowan, Paul Dervan, D. Xu, Alexei Klimentov, Anton Wolf, D. Berge, S. H. Kim, P. Puzo, Iain Alexander Bertram, Tobias Klingl, Michael Rijssenbeek, Juan Terron, Fang-ying Tsai, Simone Monzani, Chiara Debenedetti, S. González de la Hoz, Bernard Brickwedde, Jean-Francois Grivaz, M. Beretta, Thomas Naumann, Saminder Dhaliwal, Riccardo-Maria Bianchi, Joseph Izen, Ruslan Mashinistov, Quentin Buat, Alessandra Ciocio, K. Sliwa, Kurt Keys Hill, Stephanie Zimmermann, Wladyslaw Dabrowski, Andrej Filipcic, Lydia Roos, Yi-Tao Wang, Kazuya Mochizuki, Peter Love, Maximilian Georg Herrmann, David Dodsworth, V. Kartvelishvili, Santiago Juan Batista, Kayla Dawn McLean, Kota Kasahara, M. A. L. Leite, Evangelos Gazis, Adomas Jelinskas, Kazuki Motohashi, N-A. Rosien, Alessandro Gabrielli, Y. Jiang, R. Hankache, Claude Guyot, Sinead Farrington, Georg Zobernig, C. P. A. Roland, Yoji Hasegawa, Declan Andrew Millar, Xiandong Zhao, Syed Haider Abidi, Ketevi Assamagan, Alessandro Cerri, Philip Bechtle, A. Glazov, Sophie Trincaz-Duvoid, Kazuhiko Hara, Martin Florian Bessner, Irina Antonela Cioara, Daniela Salvatore, J. Griffiths, Kosuke Takeda, Darren Price, Fedor Prokoshin, Pierre Savard, Paul Fraser Harrison, D. Oliveira Damazio, Matthew Craig Mondragon, David Cameron, Giulia Ripellino, Tomasz Bold, R. M. Barnett, S. Y. Suzuki, S. J. Chen, Albert Francis Casha, Robert Stanek, J. Huston, Souad Batlamous, Vanja Morisbak, A. N. Karyukhin, T. R. Van Daalen, Chrysostomos Valderanis, Yohei Yamaguchi, Robert Les, Oleg Brandt, M. Garcia-Sciveres, and Yu Nakahama
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Large Hadron Collider, 010308 nuclear & particles physics, Branching fraction, High Energy Physics::Phenomenology, Scalar boson, 01 natural sciences, 7. Clean energy, Standard Model, Vector boson, 0103 physical sciences, Higgs boson, High Energy Physics::Experiment, Invariant mass, 010306 general physics, Boson
Abstract: We report a search for Higgs bosons that are produced via vector boson fusion and subsequently decay into invisible particles. The experimental signature is an energetic jet pair with invariant mass of O(1)TeV and O(100)GeV missing transverse momentum. The analysis uses 36.1 fb −1 of pp collision data at s=13TeV recorded by the ATLAS detector at the LHC. In the signal region the 2252 observed events are consistent with the background estimation. Assuming a 125GeV scalar particle with Standard Model cross sections, the upper limit on the branching fraction of the Higgs boson decay into invisible particles is 0.37 at 95% confidence level where 0.28 was expected. This limit is interpreted in Higgs portal models to set bounds on the wimp –nucleon scattering cross section. We also consider invisible decays of additional scalar bosons with masses up to 3TeV for which the upper limits on the cross section times branching fraction are in the range of 0.3– 1.7pb .
Published: 2019
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