341 results on '"Amit Pal"'
Search Results
102. Hydrogen Production from Biogas: Methods and Economic Analysis
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Amit Pal, Anil Kumar, and Ravindra Kumar
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Waste management ,Biogas ,Economic analysis ,Environmental science ,Hydrogen production - Abstract
In present days, H2 is mainly produced via natural gas from thermochemical methods. The importance of renewable H2 production has increased due to energy issues, global environmental, fossil fuel depletion, and pure hydrogen demand. Biogas is produced from anaerobic digestion or carbon-based waste fermentation methods. It might be a substitute resource to the creation of hydrogen. Methane (CH4) and carbon dioxide (CO2) are two significant constituents of biogas, and these are multipurpose feedstock materials for the generation of valuable chemicals and fuels. This paper presents major hydrogen generation techniques from biogas reforming in detail and a short discussion of biogas reforming's economic analysis. The effective operating parameters such as reaction temperature, gas hourly space velocity and O2/CH4 ratio are also discussed. Biogas has more potential; however, it needs more research on some issues such as deactivation of the catalyst, purification of biogas and removable of H2S. Various reforming methods can be nominated for H2 production depend on biogas composition, the need for hydrogen purity, investment availability and quantity of the desired hydrogen.
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- 2021
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103. Potential molecular mechanisms of zinc- and copper-mediated antiviral activity on COVID-19
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Rajendra Prasad, Isha Rani, Mini Bhatnagar, Parul Goel, Sunita Manhas, Anmol Goyal, and Amit Pal
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0301 basic medicine ,Antioxidant ,Coronavirus Disease 2019 (COVID-19) ,Bcl-2, B-cell lymphoma 2 ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Anti-Inflammatory Agents ,IFN, interferons ,Pharmacology ,Antioxidants ,0302 clinical medicine ,Endocrinology ,NK cells, natural killer cells ,Copper (Cu) ,Cu, copper ,chemistry.chemical_classification ,Nutrition and Dietetics ,ATP7A, copper-ATPase ,ZIP, Zrt-/Irt-like protein ,MTF-1, metal-responsive transcription factor-1 ,Nrf 2, nuclear erythroid factor 2 ,Gastrointestinal system ,Zn, zinc ,Zinc ,Zinc (Zn) ,Th, T helper cell ,Adjuvant ,NF-κB, nuclear factor-κB ,030209 endocrinology & metabolism ,ATOX1, human antioxidant protein 1 ,Antiviral Agents ,Article ,03 medical and health sciences ,ACE2, angiotensin-converting enzyme-2 ,Immune system ,ROS, reactive oxygen species ,Viral entry ,SOD, superoxide dismutase ,RdRP, RNA dependent RNA polymerase ,medicine ,Adjuvant therapy ,Humans ,CTR1, copper transporter protein ,ZnT, zinc transporter ,CCS, copper chaperone for superoxide dismutase ,ARDS, acute respiratory distress syndrome ,Reactive oxygen species ,Trace elements ,030109 nutrition & dietetics ,Zo-1, zonula occludens-1 ,SARS-CoV-2 ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Bax, bcl-2-like protein 4 ,Autophagy ,MT, metallothionein ,COVID-19 Drug Treatment ,IL, interleukin ,Clinical trial ,chemistry ,MRE, metal-responsive element ,SIRT1, NAD-dependent deacetylase sirtuin-1 ,business ,Copper ,SARS-CoV-2, severe acute respiratory syndrome coronavirus-2 - Abstract
Novel coronavirus disease 2019 (COVID-19) has spread across the globe; and surprisingly, no potentially protective or therapeutic antiviral molecules are available to treat severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, zinc (Zn) and copper (Cu) have been shown to exert protective effects due to their antioxidant, anti-inflammatory, and antiviral properties. Therefore, it is hypothesized that supplementation with Zn and Cu alone or as an adjuvant may be beneficial with promising efficacy and a favorable safety profile to mitigate symptoms, as well as halt progression of the severe form of SARS-CoV-2 infection. The objective of this review is to discuss the proposed underlying molecular mechanisms and their implications for combating SARS-CoV-2 infection in response to Zn and Cu administration. Several clinical trials have also included the use of Zn as an adjuvant therapy with dietary regimens/antiviral drugs against COVID-19 infection. Overall, this review summarizes that nutritional intervention with Zn and Cu may offer an alternative treatment strategy by eliciting their virucidal effects through several fundamental molecular cascades, such as, modulation of immune responses, redox signaling, autophagy, and obstruction of viral entry and genome replication during SARS-CoV-2 infection.
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- 2021
104. Alloys, Additive Manufacturing and Chemical Engineering
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Yuyuan Zhao, Jong Wan Hu, Amit Pal, Yuyuan Zhao, Jong Wan Hu, and Amit Pal
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- Chemical engineering, Chemistry, Engineering, Manufactures, Mechanical engineering, Mining engineering, Physics
- Abstract
Special topic volume with invited peer-reviewed papers only
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- 2024
105. Properties and Processing of Steel and Alloys, Additive Manufacturing
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Amit Pal, Nicuşor Alin Sîrbu, Yuyuan Zhao, Amit Pal, Nicuşor Alin Sîrbu, and Yuyuan Zhao
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- Chemical engineering, Chemistry, Engineering, Manufactures, Mechanical engineering, Mining engineering, Physics
- Abstract
Special topic volume with invited peer-reviewed papers only
- Published
- 2024
106. Impact of health benefit package policy interventions on service utilisation under government-funded health insurance in Punjab, India: analysis of Ayushman Bharat Pradhan Mantri Jan Arogya Yojana (PM-JAY)Research in context
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Shankar Prinja, Jyoti Dixit, Ruby Nimesh, Basant Garg, Rupinder Khurana, Amit Paliwal, and Arun Kumar Aggarwal
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Health benefit packages ,Reimbursement rates ,Health insurance ,Behavioural economics ,Universal health coverage ,Supplier-induced demand ,Public aspects of medicine ,RA1-1270 - Abstract
Summary: Background: The design of health benefits package (HBP), and its associated payment and pricing system, is central to the performance of government-funded health insurance programmes. We evaluated the impact of revision in HBP within India’s Pradhan Mantri Jan Arogya Yojana (PM-JAY) on provider behaviour, manifesting in terms of utilisation of services. Methods: We analysed the data on 1.35 million hospitalisation claims submitted by all the 886 (222 government and 664 private) empanelled hospitals in state of Punjab, from August 2019 to December 2022, to assess the change in utilisation from HBP 1.0 to HBP 2.0. The packages were stratified based on the nature of revision introduced in HBP 2.0, i.e., change in nomenclature, construct, price, or a combination of these. Data from National Health System Cost Database on cost of each of the packages was used to determine the cost-price differential for each package during HBP 1.0 and 2.0 respectively. A dose–response relationship was also evaluated, based on the multiplicity of revision type undertaken, or based on extent of price correction done. Change in the number of monthly claims, and the number of monthly claims per package was computed for each package category using an appropriate seasonal autoregressive integrated moving average (SARIMA) time series model. Findings: Overall, we found that the HBP revision led to a positive impact on utilisation of services. While changes in HBP nomenclature and construct had a positive effect, incorporating price corrections further accentuated the impact. The pricing reforms highly impacted those packages which were originally significantly under-priced. However, we did not find statistically significant dose–response relationship based on extent of price correction. Thirdly, the overall impact of HBP revision was similar in public and private hospitals. Interpretation: Our paper demonstrates the significant positive impact of PM-JAY HBP revisions on utilisation. HBP revisions need to be undertaken with the anticipation of its long-term intended effects. Funding: Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ).
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- 2024
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107. Performance Characteristics of Karanja Biodiesel Blends Using Energy Audit Technique
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Sanjay Mohite, Sagar Maji, and Amit Pal
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Diesel fuel ,Biodiesel ,Work output ,Brake ,Water cooling ,Environmental science ,Exhaust gas ,Energy consumption ,Diesel engine ,Automotive engineering - Abstract
A new methodology is used to evaluate performance and emission characteristics with the use of energy audit. This is a method to check biodiesel feasibility as blends in diesel engine. This is one of the simple and fast methods to save time and energy. In this method, heat flow analysis comprises utilisation in brake power, cooling water heat loss, heat loss in exhaust gas and heat loss in radiation which have been calculated and compared. Brake-specific energy consumption, losses in friction power and smoke have also been chosen as important characteristics of performance and emission in energy audit. These parameters of energy audit have been calculated and compared. These parameters of energy audit have been found with 10, 20 and 30% blend of biodiesel at varying brake power of 0.5–3.5 kW at 1500 rpm speed. These parameters have been found satisfactory. Higher limit of conversion of fuel’s heat energy into useful work output for B20 is found to be 29.04, 29% for diesel, 28.3% for B10 and 27.92% for B30 at brake power of 3.5 kW with lesser smoke. Karanja B-20 blend test fuel has been found to be more suitable in preliminary energy audit method, and it would be tested further for other parameters.
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- 2021
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108. A Current Review on Linear Fresnel Reflector Technology and Its Applications in Power Plants
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Amit Pal, Harwinder Singh, Amrik Singh, and R. S. Mishra
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Work (electrical) ,business.industry ,Parabolic trough ,Environmental science ,Economic analysis ,Economic feasibility ,Reflector (antenna) ,Current (fluid) ,Aerospace engineering ,business ,Solar energy ,Power (physics) - Abstract
This review paper provides a short insight on the solar energy and concentrating collectors, and it mainly comprises with the latest studies available in the literature regarding the application of solar thermal energy in power plants, linear Fresnel reflector (LFR), and its various important aspects, for instance, importance of LFR among the parabolic trough collector (PTC), performance analysis of LFR, and its application with the power plants. After reviewing a broad literature, it has been examined that reasonable price and economic feasibility of LFR could make it more viable for power plants. Additionally, past studies on optimization and economic analysis also have been reviewed in this work.
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- 2021
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109. Application of Induction Heating Technique in Biodiesel Production
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Anurag Chaurasia, Manish Jain, and Amit Pal
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Taguchi methods ,Biodiesel ,Induction heating ,Materials science ,Cavitation ,Biodiesel production ,Yield (chemistry) ,Analytical chemistry ,Induction heater ,Transesterification - Abstract
This research paper deals with production of biodiesel by transesterification using induction heating process. Optimization of process parameters for biodiesel production to obtain maximum yield using Taguchi technique has been performed, and the effect of changing molar ratio, time of reaction and power of the induction heater have been investigated, and the results are discussed. Signal-to-noise ratio, analysis of variance (ANOVA) and orthogonal array are implemented for its determination. Comparison for yield of biodiesel produced, optimal time and specific energy consumption has been made between different methods of biodiesel production such as induction heating, microwave irradiation, mechanical stirring and ultrasonic cavitation. The optimal time for maximization of yield was found to be 60 s, optimal molar ratio 8:1 and optimal power was found to be 1600 W for a yield of 92.45% for a sample size of 100 g which is comparable to other methods. The SEC of biodiesel formed by induction heating method was found to be 281 W h/kg which is lesser than magnetic stirring and hydrodynamic cavitation and comparable to ultrasonic cavitation.
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- 2021
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110. Suppression of β-catenin signaling in colon carcinoma cells by a bacterial protein
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Amit Pal, Aftab Nadeem, Sun Nyunt Wai, Athar Alam, Tanusree Ray, Karina Persson, Bernt Eric Uhlin, and Kyaw Min Aung
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Cancer Research ,Adenomatous polyposis coli ,Colorectal cancer ,Cell Survival ,MakA ,proliferation ,Cell- och molekylärbiologi ,03 medical and health sciences ,Mice ,0302 clinical medicine ,lysosomes ,Bacterial Proteins ,Cell Line, Tumor ,medicine ,Cytotoxic T cell ,Animals ,Humans ,cancer ,Vibrio cholerae ,Wnt Signaling Pathway ,Caspase ,beta Catenin ,Cell Proliferation ,Cancer och onkologi ,biology ,Chemistry ,Cytotoxins ,apoptosis ,Cancer ,β-catenin ,medicine.disease ,HCT116 Cells ,Xenograft Model Antitumor Assays ,Gene Expression Regulation, Neoplastic ,Cytosol ,Oncology ,Apoptosis ,030220 oncology & carcinogenesis ,Cancer and Oncology ,Cancer cell ,Colonic Neoplasms ,biology.protein ,Cancer research ,Cell and Molecular Biology - Abstract
Colorectal cancer is one of the leading causes of cancer-related death worldwide. The adenomatous polyposis coli (APC) gene is mutated in hereditary colorectal tumors and in more than 80% of sporadic colorectal tumors. APC mutations impair β-catenin degradation, leading to its permanent stabilization and increased transcription of cancer-driving target genes. In colon cancer, impairment of β-catenin degradation leads to its cytoplasmic accumulation, nuclear translocation, and subsequent activation of tumor cell proliferation. Suppressing β-catenin signaling in cancer cells therefore appears to be a promising strategy for new anticancer strategies. Recently, we discovered a novel Vibrio cholerae cytotoxin, motility-associated killing factor A (MakA), that affects both invertebrate and vertebrate hosts. It promotes bacterial survival and proliferation in invertebrate predators but has unknown biological role(s) in mammalian hosts. Here, we report that MakA can cause lethality of tumor cells via induction of apoptosis. Interestingly, MakA exhibited potent cytotoxic activity, in particular against several tested cancer cell lines, while appearing less toxic toward nontransformed cells. MakA bound to the tumor cell surface became internalized into the endolysosomal compartment and induced leakage of endolysosomal membranes, causing cytosolic release of cathepsins and activation of proapoptotic proteins. In addition, MakA altered β-catenin integrity in colon cancer cells, partly through a caspase- and proteasome-dependent mechanism. Importantly, MakA inhibited β-catenin-mediated tumor cell proliferation. Remarkably, intratumor injection of MakA significantly reduced tumor development in a colon cancer murine solid tumor model. These data identify MakA as a novel candidate to be considered in new strategies for development of therapeutic agents against colon cancer.
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- 2021
111. Performance and Emissions Analysis of a Dual Fuel Diesel Engine with Biogas as Primary Fuel
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S. Lalhriatpuia and Amit Pal
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Waste management ,business.industry ,Fossil fuel ,Diesel engine ,Cylinder (engine) ,law.invention ,Liquid fuel ,Diesel fuel ,Biogas ,Fuel gas ,law ,Environmental science ,Combustion chamber ,business - Abstract
The prices of fossil fuels are constantly increasing due to the limited resources and consistent rise in demand. Also, with each passing year emission regulation is getting stringent, hence alternative fuels resulting lesser exhaust emission at no expense of the performance is the need of the hour. The performance parameters and the engine emissions were investigated and compared with different dual fuel combination at varying load conditions using a single cylinder four-stroke CI engine which on modification worked as a dual fuel engine. CO, CO2, HC, and NOx are the exhaust emissions measured interpret at the various operating conditions. Two fuels, i.e., pilot fuel and gaseous fuel, when used simultaneously is referred as dual fuel mode, where we have used biogas as the gaseous fuel in this study. The three pilot fuels are injected separately inside the modified engine, namely diesel, soya–biodiesel (SBD), soya–biodiesel–ethanol (SBDE), while the biogas is primary gaseous fuel. A modification was made in the inlet air manifold of the engine by adding a gas mixer to achieve the purpose of proper blend of air and biogas before delivering the mixture to the combustion chamber of the engine. Also, a regulating lever was added to fluctuate the amount of input pilot fuel as per requirement. This investigation was done out to examine the feasibility of utilizing soya oil through blending in a CI engine. The investigation showed that the soya–biodiesel–ethanol blend can be the viable pilot fuel alternative for the CI engine. Also, the study shows that biogas is a useful entity to reduce the use of diesel fuel in CI engine due to the good liquid fuel replacement ratio.
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- 2021
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112. Experimental Analysis of Four-Stroke Single-Cylinder Diesel Engine Using Biogas as a Dual Fuel
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Pradeep Kumar Meena, Samsher, and Amit Pal
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Volumetric efficiency ,Diesel fuel ,Brake specific fuel consumption ,Thermal efficiency ,Biogas ,Waste management ,Environmental science ,Four-stroke engine ,Thrust specific fuel consumption ,Diesel engine - Abstract
Large amounts of domestic solid waste is generated every day, and most of the organic wastes which come out of the houses are not segregated properly, because most people do not use organic waste due to lack of knowledge or time management. Here, an effort has been made to develop a compact biogas plant that can be used to produce biogas on a small scale that can fulfill the essential requirement of common people from urban and rural areas for cooking, operating engines, and electricity. After that, the test evaluation of four-stroke single-cylinder diesel engine and dual fuel (diesel + biogas) in different load conditions and different entry parameters of the engine is calculated. Brake thermal efficiency (BTE) was found to be around 18.36% in diesel fuel and 21.79% in dual-fuel (DF) mode; indicated thermal efficiency (ITE) around 33.47% in DF mode and 25.61% in diesel fuel; and volumetric efficiency (VE) about 79.34% was found in DF mode and 75.24% in diesel fuel. Brake specific fuel consumption (BSFC) and indicated specific fuel consumption (ISFC) were found to be slightly higher in DF mode.
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- 2021
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113. Heterotrophic Cultivation of Microalgae in Wastewater
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Chhavi Aggarwal, Dushyant Singh, Himanshu Soni, and Amit Pal
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Total organic carbon ,geography ,geography.geographical_feature_category ,biology ,Heterotroph ,biology.organism_classification ,Photosynthesis ,Pulp and paper industry ,chemistry.chemical_compound ,Algae ,Wastewater ,chemistry ,Carbon dioxide ,Environmental science ,Bog ,Organism - Abstract
Microalgae has a very large diversity compared to any other organism. They are a versatile group of plants that are found almost everywhere such as soil, water, bog and marsh and have evolved over the years to grow and survive in different environments. Most microalgae perform photosynthesis to synthesize food from carbon dioxide and sunlight. However, in the absence of sunlight, to grow and survive they either synthesize their food in the dark environment or feed on organic carbon sources. A number of microalgae species have evolved to feed on organic carbon sources and undergo respiration to facilitate heterotrophic growth. This research focuses on heterotrophic cultivation of algae with wastewater as the growth media and briefly looks at the various cultivation processes with different microalgal strains available. Various additives to instigate the growth of microalgal strains in different cultural mediums are also discussed. This paper can be used as a basis to carry out experiments for a more economical infrastructure.
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- 2021
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114. Challenges of Battery Production: A Case Study of Electrical Vehicles in India
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Sanjeev Kumar and Amit Pal
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Electric motor ,Battery (electricity) ,business.industry ,Computer science ,Greenhouse gas ,Fossil fuel ,Production (economics) ,Energy security ,Electricity ,Propulsion ,business ,Automotive engineering - Abstract
Today, world is facing severe environmental problems of greenhouse gas emissions, urban pollution, and fossil fuel exhaustion directing energy security issues, for which electromobility possibly will be a preeminent option to counter these problems, as a road transport system in which vehicles utilize electricity for propulsion. In this transport system, power is obtained from a battery to drive the electric motor, which finally propels the vehicle. Hence, high-performance batteries of reasonable cost are the fundamental requirement for transferring the transport system from conventional (vehicles using IC engines for power requirement) to newer, i.e., electric vehicles (EVs). In India, lead–acid batteries are produced mainly, while Li-ion batteries are utilized by top brand cars for propulsion purpose. Challenging parameters for production of batteries were identified. Various important characteristics which are utilized for classification and performance evaluation of the battery technologies were studied. Some of the battery technologies were explained briefly. Simple additive weighting (SAW) method of multi-attribute decision-making (MADM) techniques were applied, for ranking the various battery technologies.
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- 2021
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115. Comparative Analysis of the Engine Emissions from CI Engine Using Diesel–Biodiesel–Ethanol Blends
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Neeraj Budhraja, Manish Jain, Amit Pal, and R. S. Mishra
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Smoke ,chemistry.chemical_compound ,Biodiesel ,Diesel fuel ,Materials science ,Ethanol ,chemistry ,Constant speed ,Pulp and paper industry ,Diesel engine ,NOx - Abstract
In the current study, four diesel–biodiesel–ethanol blends namely D90B5E5 (90% diesel, 5% biodiesel, and 5% ethanol), D85B10E5 (85% diesel, 10% biodiesel, and 5% ethanol), D75B15E10 (75% diesel, 15% biodiesel, and 10%) ethanol, and D70B20E10 (70% diesel, 20% biodiesel, and 10% ethanol) were used. Various physiochemical properties of all the blends and biodiesel were measured. The test runs of these blends were conducted on a constant speed diesel engine, and the results were compared with neat diesel. The emission results showed a considerable reduction in engine exhaust with the increase of biodiesel and ethanol concentrations in the blends. The results also showed higher emissions at higher loading conditions. The blend D70B20E10 showed the highest reduction of about 51% in CO emissions and nearly 45% reduction in HC emissions at higher load conditions, while an average increase of 4–45% in CO2 emission and 10–44% in NOX emission were also measured. Smoke opacity was a major problem for the diesel engine. The biodiesel blending reduced OPA percentage effectively; nearly 11.8% reduction was seen for D90B5E5 and 12–30% reduction was measured for D70B20E10 blend as compared to neat diesel. Thus, the experimentation showed that without compromising with the engine parameters, a noteworthy amount of pollution can be reduced by blending neat diesel with biodiesel and ethanol for IC engine fuel.
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- 2021
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116. Solid Waste Management Practices in Indian Cities
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Amit Pal and Priyanka Goyal
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Solid waste management ,2019-20 coronavirus outbreak ,Municipal solid waste ,Coronavirus disease 2019 (COVID-19) ,Management system ,Biomedical waste ,Business ,Natural resource ,Environmental planning ,Municipal solid waste management - Abstract
Solid waste management (SWM) including biomedical waste in this Covid-19 pandemic is one of the biggest challenges in India in terms of economical as well as environmental aspect. Improper practices for handling and management of solid waste drain natural resources which pollute an environment, and in turn, it causes threat to inhabitants. The purpose of the given review is to enhance understanding the concept of municipal solid waste management planning, infrastructure, components and strategies that are useful in the current Covid-19 outbreak. This paper aims to review rules and practical problem and implementation of various practices of SWM and biomedical waste. Appropriate management of solid waste could be quiet expensive in terms of resources and time as well. Systematic review has been done for the biomedical waste management system for its disposal and treatment for Covid-19. During this crisis, it is very important to find out various feasible options for properly managing and handling the waste in an effective manner which should be sustainable and safe too.
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- 2021
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117. Bio-diesel Production from Kalonji (Nigella sativa L.) Seed Oil Using Microwave Oven-Assisted Transesterification: A Sustainable Approach
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Naveen Garg and Amit Pal
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chemistry.chemical_compound ,Biodiesel ,Materials science ,chemistry ,ASTM D6751 ,Yield (chemistry) ,Microwave oven ,Nigella sativa ,Transesterification ,Methanol ,Pulp and paper industry ,Microwave - Abstract
The present work emphasizes on observational analysis of modified domestic microwave oven-assisted transesterification in order to obtain bio-diesel (in two steps) from kalonji (Nigella sativa L.) oil. To improve the obtainable bio-diesel yield, different process parameters were optimized. The parameters include system wattage, reaction time, stirrer speed, methanol to oil ratio, and catalyst loading. The optimum values for different parameters were found to be 500 W, 20 min, 30 rpm, 9:1, and 1.5 (%w/w), respectively, for this study, and the obtained bio-diesel yield was recorded as 95.47%. The properties of produced bio-diesel comply with the fuel specifications laid down in the standard ASTM D6751. The result of the assistance of microwave oven in transesterification of kalonji oil promotes the production of bio-diesel and lessens the reaction time substantially, thereby making it a sustainable approach for small-scale production.
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- 2021
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118. Molecular basis of quercetin as a plausible common denominator of macrophage-cholesterol-fenofibrate dependent potential COVID-19 treatment axis
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Kalyan Goswami, Amit Pal, Rosanna Squitti, Anil Pawar, and Mauro Rongiolettie
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Drug ,Fenofibrate ,Cholesterol ,business.industry ,media_common.quotation_subject ,Therapeutic effect ,COVID-19 ,Lipid metabolism ,Hydroxychloroquine ,General Chemistry ,Pharmacology ,Article ,Pathogenesis ,chemistry.chemical_compound ,Chemistry ,chemistry ,medicine ,Quercetin ,business ,QD1-999 ,media_common ,medicine.drug ,Nutrition - Abstract
The world's largest randomized control trial against COVID-19 using remdesivir, hydroxychloroquine, lopinavir and interferon-β1a appeared to have little or no effect on hospitalized COVID-19 patients. This has again led to search for alternate re-purposed drugs and/or effective “add-on” nutritional supplementation, which can complement or enhance the therapeutic effect of re-purposed drug. Focus has been shifted to therapeutic targets of severe acute respiratory syndrome coronavirus (SARS-CoV-2), which includes specific enzymes and regulators of lipid metabolism. Very recently, fenofibrate (cholesterol-lowering drug), suppressed the SARS-CoV-2 replication and pathogenesis by affecting the pathways of lipid metabolism in lung cells of COVID-19 patients. A preclinical study has shown synergistic effect of quercetin (a flavonoid) and fenofibrate in reducing the cholesterol content, which might be useful in COVID-19 treatment. Based on the scientific literature, use of quercetin and fenofibrate in COVID-19 seems meaningful in pharmaceutical and biomedical research, and warrants basic, experimental and clinical studies. In this article, we have summarized the contemporary findings about drug fenofibrate and its effect on membrane synthesis of COVID-19 virus along with emphasizing on possible synergistic effects of quercetin with fenofibrate.
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- 2021
119. Unexpected challenges after kidney transplant: The patient experience
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Gorham, Natalie, Meier, Raphael, Singh, Amit Pal, Chiodo, Grace, Bova, Sarah, and Niederhaus, Silke
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- 2025
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120. An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated Coagulopathy
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Rajendra Prasad, Isha Rani, Anmol Goyal, Suvarna Prasad, Parul Goel, and Amit Pal
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0301 basic medicine ,Angiogenesis ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Clinical Biochemistry ,Inflammation ,Apoptosis ,Disease ,Review Article ,Bioinformatics ,03 medical and health sciences ,0302 clinical medicine ,Coagulopathy ,Pandemic ,medicine ,Hypoxia ,business.industry ,SARS-CoV-2 ,Hypoxia (medical) ,medicine.disease ,Crosstalk (biology) ,030104 developmental biology ,030220 oncology & carcinogenesis ,medicine.symptom ,business ,Covid-19 - Abstract
Coronavirus disease 2019 (Covid-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pandemic disease which has affected more than 6.2 million people globally, with numbers mounting considerably daily. However, till date, no specific treatment modalities are available for Covid-19 and also not much information is known about this disease. Recent studies have revealed that SARS-CoV-2 infection is associated with the generation of thrombosis and coagulopathy. Fundamentally, it has been believed that a diverse array of signalling pathways might be responsible for the activation of coagulation cascade during SARS-CoV-2 infection. Henceforth, a detailed understanding of these probable underlying molecular mechanistic pathways causing thrombosis in Covid-19 disease deserves an urgent exploration. Therefore, in this review, the hypothetical crosstalk between distinct signalling pathways including apoptosis, inflammation, hypoxia and angiogenesis attributable for the commencement of thrombotic events during SARS-CoV-2 infection has been addressed which might further unravel promising therapeutic targets in Covid-19 disease.
- Published
- 2020
121. Molecular and functional resemblance of dexamethasone and quercetin: A paradigm worth exploring in dexamethasone‐nonresponsive COVID‐19 patients
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Amit Pal and Anil Pawar
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2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,Respiratory System ,Respiratory Mucosa ,Peptidyl-Dipeptidase A ,Severe Acute Respiratory Syndrome ,Dexamethasone ,chemistry.chemical_compound ,Betacoronavirus ,HLA Antigens ,Risk Factors ,Pandemic ,Influenza, Human ,Diabetes Mellitus ,Medicine ,Edema ,Humans ,Genetic Predisposition to Disease ,Obesity ,Letter to the Editor ,Pandemics ,Pharmacology ,Inflammation ,Original Paper ,Polymorphism, Genetic ,business.industry ,SARS-CoV-2 ,Serine Endopeptidases ,Age Factors ,COVID-19 ,Thrombosis ,Virology ,Original Papers ,Letters to the Editors ,Fibrosis ,chemistry ,Hypertension ,Quercetin ,Angiotensin-Converting Enzyme 2 ,business ,Coronavirus Infections ,Cytokine Release Syndrome ,medicine.drug - Abstract
The clinical features of COVID-19 pneumonia range from a mild illness to patients with a very severe illness with acute hypoxemic respiratory failure requiring ventilation and Intensive Care Unit admission.To provide a brief overview of the existing evidence for such differences in host response and outcome, and generate hypotheses for divergent patterns and avenues for future research, by highlighting similarities and differences in histopathological appearance between COVID-19 and influenza as well as previous coronavirus outbreaks, and by discussing predisposition through genetics and underlying disease.We assessed the available early literature for histopathological patterns of COVID-19 pneumonia and underlying risk factors.The histopathological spectrum of COVID-19 pneumonia includes variable patterns of epithelial damage, vascular complications, fibrosis and inflammation. Risk factors for a fatal disease include older age, respiratory disease, diabetes mellitus, obesity and hypertension.While some risk factors and their potential role in COVID-19 pneumonia are increasingly recognized, little is known about the mechanisms behind episodes of sudden deterioration or the infrequent idiosyncratic clinical demise in otherwise healthy and young subjects.The answer to many of the remaining questions regarding COVID-19 pneumonia pathogenesis may in time be provided by genotyping as well careful clinical, serological, radiological and histopathological phenotyping.
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- 2020
122. Hydroxychloroquine and Covid-19: A Cellular and Molecular Biology Based Update
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Rajendra Prasad, Anil Pawar, Kalyan Goswami, Amit Pal, and Praveen Sharma
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0301 basic medicine ,Drug ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,media_common.quotation_subject ,Clinical Biochemistry ,Review Article ,Virus diseases ,Cytokine storm ,03 medical and health sciences ,0302 clinical medicine ,Pandemic ,medicine ,Severe acute respiratory syndrome coronavirus 2 ,Intensive care medicine ,media_common ,business.industry ,Hydroxychloroquine ,Clinical trial ,030104 developmental biology ,030220 oncology & carcinogenesis ,Treatment strategy ,business ,Covid-19 ,medicine.drug - Abstract
As the time for finding a definitive and safe cure as a vaccine for novel Corona Virus Disease 2019 (Covid-19) is still far, there is need to study in depth about the other potential drugs, which can save millions of lives due to Covid-19 pandemic. Right at the center of the debate is the use of drug “Hydroxychloroquine” as a prophylaxis as well as a treatment strategy against Covid-19 in conjunction with azithromycin. In this review, we will study the cellular and molecular aspects of hydroxychloroquine, which had driven its use in Covid-19 patients, as well as its chemistry and pharmacokinetics along with clinical trials going on worldwide using hydroxychloroquine against Covid-19. Electronic supplementary material The online version of this article (10.1007/s12291-020-00900-x) contains supplementary material, which is available to authorized users.
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- 2020
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123. Rivastigmine enhances the oxidative capacity of neurons and inhibits the nitrosative and endoplasmic reticulum stress during Alzheimer's pathology
- Author
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Parul Gupta, Shubhangini Tiwari, Abhishek Singh, Amit Pal, Amit Mishra, and Sarika Singh
- Published
- 2020
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124. The transition from objectively structured practical examination (OSPE) to electronic OSPE in the era of COVID-19
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Sasikala Thallapaneni, Kalyan Goswami, Soham Biswas, Atanu Kumar Dutta, Amit Pal, Chandramallika Paul, Sibasish Sahoo, and Sathishbabu Murugaiyan
- Subjects
2019-20 coronavirus outbreak ,Educational measurement ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,assessment of educational activities ,formative assessment ,education ,e‐OSPE ,Electronic learning ,Biochemistry ,Formative assessment ,Education, Distance ,03 medical and health sciences ,ComputingMilieux_COMPUTERSANDEDUCATION ,Humans ,Molecular Biology ,Pandemics ,030304 developmental biology ,Covid‐19 ,0303 health sciences ,Medical education ,SARS-CoV-2 ,05 social sciences ,050301 education ,COVID-19 ,international health education in developing and developed countries ,Educational Measurement ,Psychology ,medical education ,0503 education ,Education, Medical, Undergraduate - Abstract
The coronavirus (COVID‐19) pandemic is forcing the medical educators to innovate and embrace online education and assessment platform. One of the most significant challenges we are facing is the formative assessment of practical skills in the undergraduate medical biochemistry education. We have designed the electronic objectively structured practical examination to facilitate the formative assessment.
- Published
- 2020
125. Rituximab related Immune Reconstitution Inflammatory Syndrome in a patient with Lymphoma
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Gene Ferretti, Ning Lu, Rahul Pawar, Lyle R Gesner,MD, Amit Pal, Ana Martinez-Tapia, and Christopher Folterman
- Published
- 2020
- Full Text
- View/download PDF
126. Solving Differential Equations Including Leguerre Polynomial via Laplace Transform
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Dr. Dinesh Verma and Amit Pal Singh
- Subjects
Applied Mathematics ,Laplace Transform ,FOS: Mathematics ,Differential Equation - Abstract
The Laplace transformation is a mathematical tool used in solving the differential equations. Laplace transformation makes it easier to solve the problem in engineering application and make differential equations simple to solve. In this paper, we will solve differential equations including Leguerre Polynomial via Laplace Transform Method. Dr. Dinesh Verma | Amit Pal Singh "Solving Differential Equations Including Leguerre Polynomial via Laplace Transform" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-2 , February 2020, URL: https://www.ijtsrd.com/papers/ijtsrd30197.pdf
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- 2020
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127. Regulatory miRNAs in Cardiovascular and Alzheimer’s Disease: A Focus on Copper
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Anna Sacco, Fabio Martelli, Amit Pal, Claudia Saraceno, Luisa Benussi, Roberta Ghidoni, Mauro Rongioletti, and Rosanna Squitti
- Subjects
Organic Chemistry ,General Medicine ,Catalysis ,Computer Science Applications ,Inorganic Chemistry ,MicroRNAs ,Alzheimer Disease ,Cardiovascular Diseases ,Humans ,Physical and Theoretical Chemistry ,Hypoxia ,Molecular Biology ,Copper ,Spectroscopy ,Aged ,Transcription Factors - Abstract
Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), are key regulators of differentiation and development. In the cell, transcription factors regulate the production of miRNA in response to different external stimuli. Copper (Cu) is a heavy metal and an essential micronutrient with widespread industrial applications. It is involved in a number of vital biological processes encompassing respiration, blood cell line maturation, and immune responses. In recent years, the link between deregulation of miRNAs’ functionality and the development of various pathologies as well as cardiovascular diseases (CVDs) has been extensively studied. Alzheimer’s disease (AD) is the most common cause of dementia in the elderly with a complex disease etiology, and its link with Cu abnormalities is being increasingly studied. A direct interaction between COMMD1, a regulator of the Cu pathway, and hypoxia-inducible factor (HIF) HIF-1a does exist in ischemic injury, but little information has been collected on the role of Cu in hypoxia associated with AD thus far. The current review deals with this matter in an attempt to structurally discuss the link between miRNA expression and Cu dysregulation in AD and CVDs.
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- 2022
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128. Conversion of non-edible Argemone Mexicana seed oil into biodiesel through the transesterification process
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Om Prakash, Amit Pal, and Syed Shahbaz Anjum
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Biodiesel ,Materials science ,biology ,Renewable Energy, Sustainability and the Environment ,020209 energy ,Energy Engineering and Power Technology ,02 engineering and technology ,Transesterification ,Raw material ,Pulp and paper industry ,biology.organism_classification ,Argemone mexicana ,Fuel Technology ,020401 chemical engineering ,Nuclear Energy and Engineering ,Scientific method ,0202 electrical engineering, electronic engineering, information engineering ,Hot plate ,0204 chemical engineering - Abstract
In the present research work, a promising and underutilized feedstock, Argemone Mexicana (AM) seed oil is converted into biodiesel through the two-step transesterification process using hot plate ma...
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- 2018
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129. MR Imaging of the Spine: Urgent and Emergent Indications
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Kyungmin Kang, Drew Bleicher, Efrat Saraf Lavi, Amit Pal, and Charif Sidani
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medicine.medical_specialty ,Disc herniation ,business.industry ,Spinal stenosis ,Space-occupying lesion ,medicine.disease ,Magnetic Resonance Imaging ,Mr imaging ,Spine ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Myelopathy ,0302 clinical medicine ,Spinal cord compression ,medicine ,Humans ,Spinal Diseases ,Radiology, Nuclear Medicine and imaging ,Radiology ,Abscess ,business ,030217 neurology & neurosurgery ,Acute low back pain - Abstract
Spinal emergencies and urgent conditions must be recognized early so that the diagnosis can be quickly confirmed and treatment can be instituted to possibly prevent permanent loss of function. The American College of Radiology provides guidelines for recognition of patients presenting with myelopathy or acute low back pain who require further evaluation for suspicion of more serious problems and contribute to appropriate imaging utilization. Spinal emergencies include spinal cord compression secondary to vertebral fracture or space occupying lesion, spinal infection or abscess, vascular or hematologic damage, severe disc herniation, and spinal stenosis.
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- 2018
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130. Mass spectrometry-assisted venom profiling of Hypnale hypnale found in the Western Ghats of India incorporating de novo sequencing approaches
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Bipin G. Nair, Athira Radhamony Murali, Sudarslal Sadasivan Nair, Nidhi Dalpatraj Jain, Nithya Kangosseri, Dileepkumar Raveendran, Ivy Rose Sebastian, Nithin Sajeev, Nayana Sudish, Muralidharan Vanuopadath, and Amit Pal
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Proteomics ,0301 basic medicine ,Proteome ,India ,Venom ,complex mixtures ,Biochemistry ,03 medical and health sciences ,Cysteine-rich secretory protein ,Tandem Mass Spectrometry ,Structural Biology ,Amino Acid Sequence ,Molecular Biology ,Phospholipase B ,biology ,General Medicine ,Venom Protein ,people.cause_of_death ,030104 developmental biology ,Secretory protein ,Snake venom ,Venomous snake ,biology.protein ,people ,Chromatography, Liquid ,Snake Venoms - Abstract
Hypnale hypnale (hump-nosed pit viper) is considered to be one among the medically important venomous snake species of India and Sri Lanka. In the present study, venom proteome profiling of a single Hypnale hypnale from Western Ghats of India was achieved using SDS-PAGE based protein separation followed by LC-MS/MS analysis. The identities of the proteins that were not established using the Mascot search were determined through de novo sequencing tools such as Novor followed by MS-BLAST based sequence similarity search algorithm and PEAKS proteomics software. The combined proteomics analysis revealed a total of 37 proteins belonging to nine different snake venom families, in which 7 proteins were exclusively identified through de novo strategies. The enzymatic and non-enzymatic venom protein families identified include serine proteases, metalloproteases, phospholipase A2, thrombin-like enzymes, phospholipase B, C-type lectins/snaclecs, disintegrins, cysteine rich secretory proteins and nerve growth factor. Among these, disintegrins, nerve growth factor, phospholipase B and cysteine rich secretory protein families were identified for the first time in HPV venom. This could possibly explain the regiospecific venom variation seen across snake species. Taken together, the venom proteome profiling on Indian Hypnale hypnale venom correlates with the clinical manifestations often seen in the envenomed victims.
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- 2018
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131. Pressurized ultrasonic production of biodiesel from Jatropha oil: optimization and energy analysis
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Raj Kumar Singh, Amit Pal, Rajiv S. Mishra, and Shashank Mohan
- Subjects
Biodiesel ,Materials science ,Renewable Energy, Sustainability and the Environment ,020209 energy ,Energy Engineering and Power Technology ,02 engineering and technology ,Transesterification ,010501 environmental sciences ,Pulp and paper industry ,01 natural sciences ,Energy analysis ,Fuel Technology ,Nuclear Energy and Engineering ,Cavitation ,Biodiesel production ,0202 electrical engineering, electronic engineering, information engineering ,Jatropha oil ,Production (economics) ,Ultrasonic sensor ,0105 earth and related environmental sciences - Abstract
The present study deals with the development of a biodiesel production reactor based on pressurized ultrasonic cavitation technique. Transesterification of Jatropha oil takes place by passi...
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- 2018
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132. Void fraction measurement using concave capacitor based sensor – Analytical and experimental evaluation
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Amit Pal and B. Vasuki
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Materials science ,Applied Mathematics ,Capacitive sensing ,010401 analytical chemistry ,Flow (psychology) ,Fraction (chemistry) ,Mechanics ,Condensed Matter Physics ,01 natural sciences ,Capacitance ,010305 fluids & plasmas ,0104 chemical sciences ,law.invention ,Capacitor ,law ,0103 physical sciences ,Two-phase flow ,Electrical and Electronic Engineering ,Porosity ,Instrumentation ,Uncertainty analysis - Abstract
Two-phase flow in pipelines is very common in the oil and gas industries. Void fraction is one of the important parameters in two-phase flow. Measurement of void fraction plays an important role in various areas of industries. Two types of measurement techniques are commonly used in electrical methods for macroscale range- variable capacitance type and variable conductance type. A comparatively low cost and non-invasive design of the concave capacitive sensor is analytically evaluated and experimentally validated to measure the void fraction inside the non-metallic pipe. The design is effective to reduce the fringing effect. The electrical model of the concave capacitance sensor is analyzed, which involves all the parasitic capacitances along with the cable capacitances. The capacitance of the sensor varies for the whole range of void fraction (0–100%). If the two phases are distilled water and air, the capacitance value varies from 94.0134 pF to 3.4377 pF experimentally for void fraction variation of 0–100%. Uncertainty analysis for the proposed sensor design along with the uncertainty budget is presented, for the whole range of measurement. The standard uncertainty is less than 0.97 pF for the whole range of measurement. The procedure for analysis is also discussed in this paper.
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- 2018
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133. Construction of capital procurement decision making model to optimize supplier selection using Fuzzy Delphi and AHP-DEMATEL
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Manoj Kumar Dash, Suryakant Manchanda, Sachin Gupta, Ashwani Vohra, Anil Kumar, and Amit Pal
- Subjects
Operations research ,Computer science ,Transparency (market) ,business.industry ,Strategy and Management ,05 social sciences ,Maintainability ,Automotive industry ,Analytic hierarchy process ,02 engineering and technology ,Total cost of ownership ,Fuzzy logic ,Procurement ,0502 economics and business ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Business and International Management ,business ,050203 business & management ,Decision-making models - Abstract
Purpose Supplier selection for capital procurement is a major strategic decision for any automobile company. The decision determines the success of the company and must be taken systematically with the utmost transparency. The purpose of this paper is to construct capital procurement decision-making model to optimize supplier selection in the Indian automobile industry. Design/methodology/approach To achieve the stated objective, a combined approach of fuzzy theory and AHP-DEMATEL is applied. Evaluation parameters are identified through an extensive literature review and criteria validation has been introduced through a Fuzzy Delphi method by using fuzzy linguistic scales to handle the vagueness of information. AHP is employed to find the priority weight of criteria, although an inter-relationship map among criteria is not possible through AHP alone since it considers all criteria as independent. To overcome this, DEMATEL is used to establish cause-effect relationships among criteria. Findings The results show that the total cost of ownership (TOC) is the first weighted criterion in supplier selection for capital procurement, followed by manufacturing flexibility and maintainability, then conformity with requirement. The cause-effect model shows that supplier profile, TOC, service support and conformity with requirement are in the cause group and are considered to be the most critical factors in selecting the supplier. Originality/value The study’s outcome can help the automobile industry to optimize their selection process in selecting their suppliers for capital procurement; the proposed model can provide guidelines and direction in this regard.
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- 2018
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134. Performance and emission characteristics of a stationary diesel engine fuelled by Schleichera Oleosa Oil Methyl Ester (SOME) produced through hydrodynamic cavitation process
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Amit Pal, M. Emran Khan, Uttam Ghosh, and Ashok Kumar Yadav
- Subjects
Thermal efficiency ,Biodiesel ,Materials science ,Waste management ,Renewable Energy, Sustainability and the Environment ,020209 energy ,Process Chemistry and Technology ,Organic Chemistry ,02 engineering and technology ,Four-stroke engine ,Diesel engine ,Catalysis ,Brake specific fuel consumption ,Diesel fuel ,Fuel Technology ,Geochemistry and Petrology ,lcsh:TP690-692.5 ,0202 electrical engineering, electronic engineering, information engineering ,Thrust specific fuel consumption ,lcsh:Petroleum refining. Petroleum products ,NOx - Abstract
In this study, the performance and emission characteristics of biodiesel blends of 10, 20, 30 and 50% from Schleichera Oleosa oil based on hydrodynamic cavitation were compared to diesel fuel, and found to be acceptable according to the EN 14214 and ASTM D 6751 standards. The tests have been performed using a single cylinder four stroke diesel engine at different loading condition with the blended fuel at the rated speed of 1500 rpm. SOME (Schleichera Oleosa Oil Methyl Ester) blended with diesel in proportions of 10%, 20%, 30% and 50% by volume and pure diesel was used as fuel. Engine performance (specific fuel consumption and brake thermal efficiency) and exhaust emission (CO, CO2 and NOx) were measured to evaluate the behaviour of the diesel engine running on biodiesel. The results show that the brake thermal efficiency of diesel is higher and brake specific fuel consumption is lower at all loads followed by blends of SOME and diesel. The performance parameter for B10, B20, B30 and B50 were also closer to diesel and the CO emission was found to be lesser than diesel while there was a slight increase in the CO2 and NOx. SOME produced by using hydrodynamic cavitation seems to be efficient, time saving and industrially viable. The experimental results revel that SOME-diesel blends up to 50% (v/v) can be used in a diesel engine without modifications. Keywords: Performance, Emission, Diesel engine, Schleichera Oleosa Oil, Biodiesel hydrodynamic cavitation (HC)
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- 2018
135. Performance Evaluation and Analysis of Underutilized Argemone Mexicana seed oil Biodiesel in Single Cylinder 4-S Diesel Engine
- Author
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Amit Pal
- Subjects
General Computer Science ,Mechanics of Materials ,Electrical and Electronic Engineering ,Civil and Structural Engineering - Abstract
The aim of current research effort is to evaluate the performance of much less utilized Argemone Mexicana seed oil methyl ester in single cylinder, water-cooled, 4-S diesel engine. The Argemone Mexicana is an agricultural weed, a plant of wasteland; its use led to the resource conservation. The methyl ester or biodiesel obtained by Argemone Mexicana seed oil is produced by the course of transesterification process. This process consists of pretreatment of vegetable oil with acid catalyst due to high FFA content followed by base catalyzed transesterification. The essential properties of transesterified Argemone Mexicana seed oil are tested and compared with natural diesel. The biodiesel blends with diesel in the combination of B10, B20, B30, B40 and B50 are utilized in a compression-ignition engine, its performance parameters are examined and compared with natural diesel. The lower blends of biodiesel exhibits similar characteristics to diesel without any modification in the design of engine. This experimental work testified that the blending of diesel with biodiesel obtained from Argemone Mexicana oil in diesel engine is a feasible alternative for depletion of petroleum diesel.
- Published
- 2019
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136. PIEZO1 mutation: a rare aetiology for fetal ascites
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Stolyar, Helen, primary, Berry, Teresa, additional, Singh, Amit Pal, additional, and Madan, Ichhcha, additional
- Published
- 2021
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137. Xanthone from Swertia chirata Exerts Chemotherapeutic Potential Against Colon Carcinoma
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Atish Barua, Pritha Choudhury, Niraj Nag, Anirban Nath, Sabyasachi Kundagrami, Amit Pal, Chinmay Kumar Panda, and Prosenjit Saha
- Subjects
Multidisciplinary - Published
- 2022
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138. Semantic Implicit Neural Scene Representations With Semi-Supervised Training
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Kohli, Amit Pal Singh, primary, Sitzmann, Vincent, additional, and Wetzstein, Gordon, additional
- Published
- 2020
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139. Recent Advances in Mechanical Engineering : Select Proceedings of RAME 2020
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Anil Kumar, Amit Pal, Surendra Singh Kachhwaha, Prashant Kumar Jain, Anil Kumar, Amit Pal, Surendra Singh Kachhwaha, and Prashant Kumar Jain
- Subjects
- Thermodynamics, Heat engineering, Heat transfer, Mass transfer, Vehicles, Industrial engineering, Production engineering
- Abstract
This book presents the select proceedings of the second International Conference on Recent Advances in Mechanical Engineering (RAME 2020). The topics covered include aerodynamics and fluid mechanics, automation, automotive engineering, composites, ceramics and polymers processing, computational mechanics, failure and fracture mechanics, friction, tribology and surface engineering, heating and ventilation, air conditioning system, industrial engineering, IC engines, turbomachinery and alternative fuels, machinability and formability of materials, mechanisms and machines, metrology and computer-aided inspection, micro- and nano-mechanics, modelling, simulation and optimization, product design and development, rapid manufacturing technologies and prototyping, solid mechanics and structural mechanics, thermodynamics and heat transfer, traditional and non-traditional machining processes, vibration and acoustics. The book also discusses various energy-efficient renewable and non-renewable resources and technologies, strategies and technologies for sustainable development and energy & environmental interaction. The book is a valuable reference for beginners, researchers, and professionals interested in sustainable construction and allied fields.
- Published
- 2021
140. Review on direct transesterification method using recent technologies
- Author
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Amrik Singh, Amit Pal, and Harpreet Kau
- Abstract
Nowadays the research is focused on microalgae oil for biodiesel production because of high yield as compared to vegetable plant oil and it fixes carbon dioxide from atmosphere. It is a third-generation biofuel that can easily replace diesel which will deplete in couple of decades and can be used in diesel engine without any modification simultaneously cutting down the engine emissions. The biodiesel production from microalgae is a complex process which includes harvesting, drying, cell disruption, lipid extraction and biodiesel production. However, using direct in-situ transesterification these steps are reduced, and biodiesel production get simplified. Here in this wet algal biomass directly transesterified using alcohol, catalyst and solvents thus eliminating the drying and oil extraction process. This paper reviews the different methods used for direct transesterification in order to reduce the cost of production and increase the biodiesel yield. For cell different techniques are studied and analyzed the best technique from literature review.
- Published
- 2018
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141. Improving the Tractive Performance with Four-Wheel Drive (4WD) System
- Author
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Neeraj Budhraja and Amit Pal
- Abstract
This paper gives a brief study of the components, operating modes, merits and demerits of a four-wheel drive system over two-wheel drive system, and a case study of Mahindra Scorpio S11 is done for tractive effort by 4WD and 2WD (front wheel drive). The results for Mahindra Scorpio S11 showed that the tractive effort by 4WD system increases as the gear ratio decreases, i.e., highest for reverse gear (14362.96 Nm) with gear ratio 3.28:1, 1st gear (13000.00 Nm) with gear ratio 2.97:1, 2nd gear (9066.67 Nm) with gear ratio 2.07:1 whereas lowest for 6th gear (2451.85 Nm) with gear ratio 0.56:1. Similar results for tractive efforts by 2WD (front wheel drive) system can be depicted, i.e., highest tractive effort for reverse gear (7674.07 Nm), 1st gear (6940.74 Nm), 2nd gear (4837.04 Nm) whereas lowest for 6th gear (1311.11 Nm). As observed, the tractive effort by a 4WD system is comparatively higher than a 2WD (front wheel drive) vehicle. Thus, this results into reduced wheel slippage tendency, better climbing capability in hilly areas and better driving control over the vehicle on the low frictional surfaces such as wet/snowy surfaces. Whereas additional components in 4-wheel drive system adds on weight; increases cost, maintenance, repair, noise and vibrations; and makes the construction comparatively more complex.
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- 2018
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142. Garlic dehydration inside heat exchanger-evacuated tube assisted drying system: Thermal performance, drying kinetic and color index
- Author
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Anand Kushwah, M.K. Gaur, Amit Pal, and Anil Kumar
- Subjects
0106 biological sciences ,Solar dryer ,Exergy ,Materials science ,Water flow ,04 agricultural and veterinary sciences ,Horticulture ,Pulp and paper industry ,medicine.disease ,01 natural sciences ,010602 entomology ,Insect Science ,Heat exchanger ,Thermal ,040103 agronomy & agriculture ,Exergy efficiency ,medicine ,0401 agriculture, forestry, and fisheries ,Dehydration ,Agronomy and Crop Science ,Water content ,Food Science - Abstract
An experimental investigation was done on an advanced evacuated tube-assisted solar drying system without and with load conditions at various water flow rates (10 L/h, 20 L/h, and 30 L/h) to evaluate its performance analysis. 79.56 °C maximum greenhouse air temperature was recorded without load at 30 L/h water flow rate with an average solar intensity of 850 W/m2. Highest value of drying rate (DR) is 1.48 kgH2O/kg dry solid/h and the maximum efficiency of solar collector (SC) and solar dryer (SD) is 43.62% and 55.28%, respectively, at 30 L/h water flow rate. Garlic was dehydrating from 70% to 8% (wb) moisture content (MC). The maximum exergy efficiency (EE) and minimum exergy loss were 57.64% at 30 L/h water flow rate and 4.58 W at 10 L/h water flow rate. Quality assessment is also carried out for dried garlic samples in the heat exchanger –evacuated tube assisted drying system (HE-ETADS). Color conservation (indices) of dehydrated garlic sample is best in HE-ETADS (Lo = 60.42, ao = −0.92, and bo = 11.54) in comparison to old-style (traditional) drying process (Lo = 58.89, ao = - 0.67, and bo = 5.99). Therefore, the developed drying system represented not only good financial returns but also better product quality. The present system provides interesting options for the entry of this type of collectors in medium-scale applications in the agricultural and industrial sectors.
- Published
- 2021
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- View/download PDF
143. Response of dust accumulation on roadside plant species due to open cast mining at Jhansi-Allahabad NH-76, Uttar Pradesh, India
- Author
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Amit Pal and Priyanka Singh
- Subjects
Protein content ,Biological pigment ,Toxicology ,Pollution ,business.industry ,media_common.quotation_subject ,Plant species ,Open-pit mining ,Environmental science ,Uttar pradesh ,business ,media_common - Published
- 2017
- Full Text
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144. Comparative study of biodiesel production methods from Yellow Oleander oil and its performance analysis on an agricultural diesel engine
- Author
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Uttam Ghosh, Amit Pal, Ashok Kumar Yadav, and Saurabh Kumar Gupta
- Subjects
Biodiesel ,Renewable Energy, Sustainability and the Environment ,020209 energy ,02 engineering and technology ,Building and Construction ,Pulp and paper industry ,Diesel engine ,Yellow oleander ,020401 chemical engineering ,Cavitation ,Biodiesel production ,Ultrasonic cavitation ,0202 electrical engineering, electronic engineering, information engineering ,Environmental science ,0204 chemical engineering - Abstract
In this present work, biodiesel is produced from Yellow Oleander oil using different methods such as hydrodynamic cavitation (HC), ultrasonic cavitation (UC) and conventional mechanical stirring (M...
- Published
- 2017
- Full Text
- View/download PDF
145. Experimental Studies on Utilization of Prunus armeniaca L. (Wild Apricot) Biodiesel as an Alternative Fuel for CI Engine
- Author
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Alok Manas Dubey, Ashok Kumar Yadav, and Amit Pal
- Subjects
Biodiesel ,Environmental Engineering ,ASTM D6751 ,Renewable Energy, Sustainability and the Environment ,Chemistry ,020209 energy ,EN 14214 ,02 engineering and technology ,Transesterification ,Diesel engine ,Brake specific fuel consumption ,Diesel fuel ,020401 chemical engineering ,0202 electrical engineering, electronic engineering, information engineering ,Organic chemistry ,Food science ,0204 chemical engineering ,Waste Management and Disposal ,Cetane number - Abstract
In present research work, Prunus armeniaca L. (Wild Apricot) Seed oil has been investigated to produce biodiesel. The free fatty acid (FFA) content of the Prunus armeniaca oil (PAO) was
- Published
- 2017
- Full Text
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146. Performance, emission and combustion characteristics of an Indica diesel engine operated with Yellow Oleander (Thevetia peruviana) oil biodiesel produced through hydrodynamic cavitation method
- Author
-
Ashok Kumar Yadav, Alok Manas Dubey, Amit Pal, and M. Emran Khan
- Subjects
Thermal efficiency ,Biodiesel ,Materials science ,Waste management ,Renewable Energy, Sustainability and the Environment ,020209 energy ,Exhaust gas ,02 engineering and technology ,Building and Construction ,Combustion ,Pulp and paper industry ,Diesel engine ,Diesel fuel ,chemistry.chemical_compound ,chemistry ,0202 electrical engineering, electronic engineering, information engineering ,Nitrogen oxide ,Unburned hydrocarbon - Abstract
The present work deals about the performance, emission and combustion characteristics of a four-cylinder, direct injection, water-cooled, Indica diesel engine fuelled with biodiesel produced through the hydrodynamic cavitation method from an underutilised and potential feedstock Yellow Oleander (Thevetia peruviana) oil. Engine tests were performed with neat diesel and biodiesel blends of 10%, 20% and 30% from Yellow Oleander oil at different engine speeds. Experimental results showed that biodiesel produced through the hydrodynamic cavitation technique with a 1% w/w catalyst percentage, 6:1 molar ratio and 35 min reaction time was equal to 97.5%. During engine performance tests, biodiesel blends showed higher brake-specific fuel consumption, brake thermal efficiency (for lower blends up to 20%) and exhaust gas temperature than diesel fuel. Engine emissions showed higher nitrogen oxide, but a decreased amount of smoke opacity, carbon monoxide, unburned hydrocarbon and favourable p–θ diagram as comp...
- Published
- 2017
- Full Text
- View/download PDF
147. Biodiesel production from microalgae oil through conventional and ultrasonic methods
- Author
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Amrik Singh, Sagar Maji, and Amit Pal
- Subjects
Biodiesel ,biology ,Waste management ,Renewable Energy, Sustainability and the Environment ,020209 energy ,Linoleic acid ,Energy Engineering and Power Technology ,02 engineering and technology ,Transesterification ,010501 environmental sciences ,Neochloris oleoabundans ,biology.organism_classification ,01 natural sciences ,Palmitic acid ,Algae fuel ,Oleic acid ,chemistry.chemical_compound ,Fuel Technology ,Nuclear Energy and Engineering ,chemistry ,Biodiesel production ,0202 electrical engineering, electronic engineering, information engineering ,Food science ,0105 earth and related environmental sciences - Abstract
In the present study, the oil extracted from the microalga Neochloris oleoabundans was used for producing biodiesel. The viscosity of microalgal oil was very high so transesterification was done by an ultrasonic method and a simple basic method. Free fatty acid content in oil was found high so a two-step transesterification reaction was used. Maximum yield of algal oil methyl ester was acquired by the ultrasonic method (98%) with improved physicochemical characteristics, whereas the biodiesel yield obtained by simple transesterification process was low (91%). The maximum oil content in N. oleoabundans was found to be 42% and major fatty acids include palmitic acid, oleic acid, and linoleic acid. Finally, it was conferred that the ultrasonic-assisted transesterification method is the best technique for biodiesel production from microalgal oil.
- Published
- 2017
- Full Text
- View/download PDF
148. Lesions of the Petrous Apex: Clues to Narrowing the Differential Diagnosis on Imaging
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Chariff Sidani, Gabriela de la Vega Muns, and Amit Pal
- Subjects
medicine.medical_specialty ,business.industry ,Petrous Apex ,Medicine ,Neurology (clinical) ,Radiology ,Differential diagnosis ,business - Published
- 2017
- Full Text
- View/download PDF
149. Organic Waste Management
- Author
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Manish Jain and Amit Pal
- Subjects
Waste management ,Scale (chemistry) ,Environmental science ,Biodegradable waste ,Sustainable living ,Reuse - Abstract
In this study effects of organic and inorganic wastes on the environment are studied and proper solutions to the various problems are suggested. After that, survey of various sites is done to understand how the waste management is done at a large scale. The end goal is to effectively implement the 3 R’s (Reuse, Reduce and Recycle) so that utilization of various resources can be reduced and the amount of waste generated can be reduced. Some simple ways for a sustainable living were suggested which are easy to implement in our daily lives.
- Published
- 2020
- Full Text
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150. Fabrication of Rapid Compression Machine with Variable Compression Ratio - A Review
- Author
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Md Nazeem Khan, Mohammad Zunaid, and Amit Pal
- Published
- 2020
- Full Text
- View/download PDF
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