Search

Abstract Aim Customer discovery, an entrepreneurial and iterative process to understand the context and needs of potential adoption agencies, may be an innovative strategy to improve broader dissemination of evidence-based interventions. This paper describes the customer discovery process for the Building Healthy Families (BHF) Online Training Resources and Program Package (BHF Resource Package) to support rural community adoption of an evidence-based, family healthy weight program. Methods The customer discovery process was completed as part of a SPeeding Research-tested INTerventions (SPRINT) training supported by the U.S. Centers for Disease Control and Prevention. Customer discovery interviews (n=47) were conducted with people that could be potential resource users, economic buyers, and BHF adoption influencers to capture multiple contextual and needs-based factors related to adopting new evidence-based interventions. Qualitative analyses were completed in an iterative fashion as each interview was completed. Results The BHF Resource Package was designed to be accessible to a variety of implementation organizations. However, due to different resources being available in different rural communities, customer discovery interviews suggested that focusing on rural health departments may be a consistent setting for intervention adoption. We found that local health departments prioritize childhood obesity but lacked the training and resources necessary to implement effective programming. Several intervention funding approaches were also identified including (1) program grants from local and national foundations, (2) healthcare community benefit initiatives, and (3) regional employer groups. Payment plans recommended in the customer discovery interviews included a mix of licensing and technical support fees for BHF delivery organizations, potential insurance reimbursement, and family fees based on ability to pay. Marketing a range of BHF non-weight related outcomes was also recommended during the customer discovery process to increase the likelihood of BHF scale-up and sustainability. Conclusions Engaging in customer discovery provided practical directions for the potential adoption, implementation, and sustainability of the BHF Resource Package. However, the inconsistent finding that health departments are both the ideal implementation organization, but also see childhood obesity treatment as a clinical service, is concerning.

Abstract Uveal cancer (UM) offers a complex molecular landscape characterized by substantial heterogeneity, both on the genetic and epigenetic levels. This heterogeneity plays a critical position in shaping the behavior and response to therapy for this uncommon ocular malignancy. Targeted treatments with gene-specific therapeutic molecules may prove useful in overcoming radiation resistance, however, the diverse molecular makeups of UM call for a patient-specific approach in therapy procedures. We need to understand the intricate molecular landscape of UM to develop targeted treatments customized to each patient's specific genetic mutations. One of the promising approaches is using liquid biopsies, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), for detecting and monitoring the disease at the early stages. These non-invasive methods can help us identify the most effective treatment strategies for each patient. Single-cellular is a brand-new analysis platform that gives treasured insights into diagnosis, prognosis, and remedy. The incorporation of this data with known clinical and genomics information will give a better understanding of the complicated molecular mechanisms that UM diseases exploit. In this review, we focused on the heterogeneity and molecular panorama of UM, and to achieve this goal, the authors conducted an exhaustive literature evaluation spanning 1998 to 2023, using keywords like "uveal melanoma, “heterogeneity”. “Targeted therapies”," "CTCs," and "single-cellular analysis".

Abstract In this study, a novel nanobiocomposite consisting of agar (Ag), tragacanth gum (TG), silk fibroin (SF), and MOF-5 was synthesized and extensively investigated by various analytical techniques and basic biological assays for potential biomedical applications. The performed Trypan blue dye exclusion assay indicated that the proliferation percentage of HEK293T cells was 71.19%, while the proliferation of cancer cells (K-562 and MCF-7) was significantly lower, at 10.74% and 3.33%. Furthermore, the Ag-TG hydrogel/SF/MOF-5 nanobiocomposite exhibited significant antimicrobial activity against both E. coli and S. aureus strains, with growth inhibition rates of 76.08% and 69.19% respectively. Additionally, the hemolytic index of fabricated nanobiocomposite was found approximately 19%. These findings suggest that the nanobiocomposite exhibits significant potential for application in cancer therapy and wound healing.

QCA technology presented as a new paradigm to replace CMOS technology in the nanoscale. QCA technology represents binary information by cell polarization, not as a voltage level. The basic blocks in QCA technology are the majority gate and inverter. Efficient building blocks are important to get whole efficient circuits. This article aims to present novel configurations for the inverter block that offer advantages in terms of temperature tolerance, cell count, and area efficiency. Moreover, a Repeater gate with high efficiency is proposed to demonstrate their versatility. The proposed inverter has efficient improvements by 2%, 4.4%, 11%, and 17.5% over the best-reported inverter block at 10 K, 100 K, 150 K, and 200 K, respectively. The circuits presented in this study were designed and validated using QCADesigner software v 2.0.3, and the energy consumption of the proposed designs was assessed using QCAPro tools.

The purpose of this study is evaluating the reduction of the government's financial burden through the typology of drivers affecting generational accounting in the capital market by action research. In terms of methodology, this study has used Colaizzi's model (1978) to implement action research steps. Therefore, based on this model, first, through interviews with experts and open coding, an effort was made to identify n Effective drivers on the implementation of generational accounting in capital market companies. Then, in order to validate the propositions, a critical evaluation was done to compare the propositions with similar researches, so that the propositions can enter the stage of forming a focus group to discuss and exchange opinions for the cognitive separation of each proposition in the form of a category. The results showed that a total of 22 propositions were identified from a total of 12 interviews and 217 open codes created. On the other hand, it was determined in the quantitative section, 22 criteria identified in 4 categories were the creators of the generational accounting typology framework of capital market companies. IntroductionOne of the most emerging concepts in the field of accounting knowledge, which in recent years has become a factor connecting the public sector to achieve sustainable development in the private sector, is generational accounting. Created to measure the relative financial burden on future generations, generational accounting is considered one of the financial tools of governments, both in the public and private sectors, that can help balance the circulation of cash in social contexts. Since industries operating in the capital market seek to provide financial resources to advance their business goals and facilitate economic growth and development, attention to the processes of allocating financial resources through the type of government support governance can reduce the financial burden on future generations. The purpose of this study is to evaluate the reduction of the government's financial burden through the typology of drivers affecting generational accounting in the capital market using action research. MethodologyIn terms of methodology, this study has used Colaizzi's model (1978) to implement action research steps. Therefore, based on this model, first, through interviews with experts and open coding, an effort was made to identify effective drivers influencing the implementation of generational accounting in capital market companies. Then, in order to validate the propositions, a critical evaluation was conducted to compare the propositions with similar research, so that the propositions could enter the stage of forming a focus group to discuss and exchange opinions for the cognitive separation of each proposition into a category. Then, through a Q evaluation checklist, each statement was scored between +4 and -4, and finally, a 4-level matrix was created to establish a foundation of effective drivers in the implementation of generational accounting, to reduce the government's financial burden on future generations. ResultAs it was determined during the research process, first through interviews and open coding, generational accounting propositions were identified. Then, to achieve validity, a matching between similar researches was performed to provide the possibility of entering the statements identified in the Q analysis model for the cognitive classification of this phenomenon in the context of capital market companies. Subsequently, by forming a focus group to determine the cognitive categories of the examined concept, during four sessions and by creating a Q evaluation checklist from +4 to -4 in 22 slots according to the identified propositions, the necessary actions were taken, and participants were asked to place each proposition in one of the 22 slots of the Q evaluation checklist. Then, through the Wiremax matrix, cognitive classes were determined regarding the separation of drivers affecting the implementation of generational accounting, and the results indicated the existence of four cognitive classes, which can be effective in reducing the financial burden of governments on future generations. The results showed that a total of 22 propositions were identified from a total of 12 interviews and 217 open codes were created. On the other hand, it was determined in the quantitative section that 22 criteria identified in four categories formed the creators of the generational accounting typology framework of capital market companies. ConclusionThe results showed that focusing on net transfer payments in the embargoed conditions of the country's industries can be considered a form of contingency governance that aims to balance the financial flow in the country's economic system. It reduces the high dependence of industries on developed economies in terms of providing resources or technological knowledge and helps balance the financial burden of the government in saving resources. Because the inefficiency of the economic infrastructure of the capital market system does not allow for the optimal allocation of resources to industries, the government sees no other way to prevent negative economic growth and the influence of other macro-economic factors, such as inflation, other than the allocation of resources through transfer payments. Although it is possible to infer the consequence of economic stickiness due to political maneuvers in the shadow of transfer payments, industries have no choice but to accept the role of the government in receiving transfer resources due to the lack of commercial exchange and the use of strategies with similar foreign companies. It is also important to mention that the lack of similar research with the analytical nature of this study makes it impossible to compare the results with other research.

Effective instruction is a determinant of success in learning Arabic. With it, learning objectives can be achieved more quickly and are more enjoyable, whereas without them, learning objectives will take longer and tend to be boring. Slavin offers a theory in determining whether learning can be assessed as effective or not, namely by Quality of Instruction, Appropriate Levels of Instruction, Incentive, and Time (QAIT). Therefore, researchers want to know whether learning at Madrasah Miftahul Ulum Angsokah Timur Madura is effective or not by analyzing it with the theory offered by Slavin. This research uses qualitative methods and includes field research. The data collection uses interviews and observations which will then be analyzed using the Miles and Huberman models. The results of this research show that learning at Madrasah Miftahul Ulum Angsokah Timur Madura is effective on one side and less effective on the other side based on Slavin theory, namely effective on the incentive and time side and not on the quality and appropriateness side.

Purpose: Cocopeat resources in Iran are limited and unsuitable, and they must be imported from abroad at a high cost. It is therefore essential to evaluate suitable growth media to replace cocopeat. Method: During this experiment, we conducted a completely randomized experimental design with seven types of growing media in a greenhouse with two layers of hexane coating, at the flower and ornamental plant research station in Lahijan city. Seven growth substrate treatments were investigated, including: (100%perlite), (75%cocopeat + 25%perlite), (50%tea waste + 25%peanut shells compost + 25%perlite), (50%tea waste +%25 Azolla + %25 Perlite), (50%peanut shells compost + 25%azolla + 25%perlite), (50%peanut shells compost + 25%tea waste +25% azolla) and (25%peanut shells compost + 25%tea Waste + 25%azolla + 25%perlite). Results: According to the results, growth media containing peanut shells, Azolla composts, and tea waste are effective and recommended, which can significantly reduce the use of cocopeat. A substrate containing compost had a better effect on the morphological and physiological characteristics of Gerber. Conclusion: The yield of Gerbera varied greatly among growth substrates, and flower performance was better in some substrates than in cocopeat. The favorable effect of composted substrates on Gerbera yield allows the selection of the growth substrate. Highlights · The introduction of a new growing medium led to a significant reduction in the consumption of Cocopeat. · The Cocopeat-free growing medium has produced Gerbera of improved morphological and physiological characteristics. · The introduction of new growth substrate combinations containing compost replaces the Cocopeat substrate and produces Gerbera of desirable quality.

Teachers have positive perceptions about the implementation of the Minimum Competency Assessment (MCA) and reading literacy. However, mathematics teachers also need to have a perception of students' numeracy skills that are assessed using the MCA instrument. Teachers experience various challenges and difficulties in improving learning to strengthen numeracy. This study aims to describe teachers' perceptions of students' numeracy competencies measured using MCA and to identify efforts made by teachers to strengthen students' numeracy competencies. This type of research is descriptive research with a qualitative approach. The results of this study indicate that teachers' perceptions of students' numeracy competence measured using the MCA instrument are positive (agree) so that teachers can make appropriate efforts in improving the quality of learning and strengthening numeracy. The efforts that teachers can make are looking for information on achievement results, reading report card data, identifying the root of the problem, and fixing the problem. Positive teacher perceptions encourage teachers to make appropriate efforts in strengthening students' numeracy competencies and support schools to develop data-based programs. Guru memiliki persepsi positif tentang pelaksanaan Asesmen Kompetensi Minimum (MCA) dan literasi membaca. Namun, guru matematika juga perlu memiliki persepsi tentang kemampuan numerasi siswa yang dinilai menggunakan instrumen MCA. Guru mengalami berbagai tantangan dan kesulitan dalam memperbaiki pembelajaran untuk menguatkan numerasi. Penelitian ini bertujuan untuk mendeskripsikan persepsi guru tentang kompetensi numerasi siswa yang diukur menggunakan MCA dan untuk mengidentifikasi upaya yang dilakukan oleh guru sebagai penguatan kompetensi numerasi siswa. Jenis penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Hasil penelitian ini menunjukkan bahwa persepsi guru tentang kompetensi numerasi siswa yang diukur menggunakan instrumen MCA adalah positif (setuju) sehingga guru dapat melakukan upaya yang tepat dalam memperbaiki kualitas pembelajaran dan melakukan penguatan numerasi. Adapun upaya yang guru dapat lakukan adalah mencari informasi hasil capaian, membaca data rapor pendidikan, mengidentifikasi akar permasalahan, dan membenahi masalah. Persepsi guru yang positif mendorong guru agar dapat melakukan upaya yang tepat dalam menguatkan kompetensi numerasi siswa dan mendukung sekolah menyusun program berdasarkan data.

Higher Education (PT) as a provider of higher education has an important role in efforts to implement religious moderation, unfortunately, in recent years universities have become fertile fields for regeneration of groups that seek to undermine the existence of the Unitary State of the Republic of Indonesia (NKRI). In its implementation, the Ministry of Religious Affairs established a Moderation House in PTKIN, while in PTU there has been no special attention related to this. In particular, this study aims to find out the concept of implementing diverse moderation in Unwahas, which is a PTU under the auspices of the Ministry of Education and Culture of Research and Technology. This research is a qualitative research using data collection including documents, interviews, and observations. This study found that the implementation of religious moderation at Wahid Hasyim University was carried out in at least two strategic steps, namely through structured and academic programs. The structured program is a program that has been planned and implemented by the Aswaja Center Management and Young Aswaja Activists, Wahid Hasyim University, while academic means through the curriculum of the General Basic Course (MKDU), implemented in the Semester Learning Plan (RPS) of Islamic Religious Education Courses, to Aswajaan, Pancasila and Citizenship and also Compulsory Curriculum Courses (MKWK).

Abstract In today’s context, the adoption of sustainable wastewater treatment methods is crucial. River estuaries have the potential to offer an economically viable and environmentally friendly solution for wastewater treatment through the flocculation of pollutants. This study investigates the role of river estuaries flowing into the southern part of the Caspian Sea in the treatment of heavy metals. Two sets of experiments were designed for this purpose. The first set involved adjusting a series of discrete aquaria in various salinity regimes, while the second set utilized only one aquarium. The results from the first set indicate the capacity of the studied estuaries to remove heavy metals through the flocculation process in the following order: Zn (70%) > Mn (60%) > Cu (49%) > Pb (24%) > Ni (19%). However, the removal rates in the second set were reduced as follows: Zn (57%) > Mn (56%) > Cu (40%) > Pb (20%) > Ni (17%). It was observed that the flocculation process exhibits an unstable nature. Furthermore, the findings reveal that heavy metals flocculation primarily occurs upstream of the estuary. However, instability in the flocculation process occurs downstream, where water parameters undergo drastic changes. Statistical analyses indicate that an increase in pH plays a significant role in the destabilization of flocs. Conversely, the initial concentration of heavy metals, dissolved oxygen, and redox potential have a positive impact on the flocculation process.

Abstract Pirfenidone (PFD), one acceptable medication for treating idiopathic pulmonary fibrosis (IPF), is not well tolerated by patients at full doses. Hence, employing of some approaches such as combination therapy may be applicable for increasing therapeutic efficacy of PFD. Losartan (LOS), an angiotensin II receptor antagonist, could be a suitable candidate for combination therapy because of its stabilizing effect on the pulmonary function of IPF patients. Therefore, this study aimed to investigate the effects of LOS in combination with PFD on bleomycin (BLM)-induced lung fibrosis in rats. BLM-exposed rats were treated with LOS alone or in combination with PFD. The edema, pathological changes, level of transforming growth factor-β (TGF-β1), collagen content, and oxidative stress parameters were assessed in the lung tissues. Following BLM exposure, the inflammatory response, collagen levels, and antioxidant markers in rat lung tissues were significantly improved by PFD, and these effects were improved by combination with LOS. The findings of this in vivo study suggest that the combined administration of PFD and LOS may provide more potent protection against IPF than single therapy through boosting its anti-inflammatory, anti-fibrotic, and anti-oxidant effects. These results hold promise in developing a more effective therapeutic strategy for treating of lung fibrosis.

Background: Focusing on the health and wellness within educational settings is essential, as it plays a vital role in measuring the effectiveness of educational processes. Given the correlation between self-compassion and benefits of empathy on academic well-being, the present study investigated the mediating role of academic buoyancy in high school students.Methods: Using a descriptive-correlational approach, structural equation modeling (SEM) was employed to analyze the interplay between variables. Through multistage cluster sampling method, 384 high school students were selected between February and April 2023 in Ahvaz, Iran. The participants were asked to fill out School Related Well-Being Scale (SWBS), Self-Compassion Scale (SCS), Empathy Assessment Scale (EAS), and Academic Buoyancy Scale (ABS). The proposed model was evaluated using SEM. Statistical analysis was performed using SPSS Amos version 25.Results: Significant positive correlations were found between self-compassion and academic well-being (r=0.22, P=0.008), as well as between self-compassion and academic buoyancy (r=0.37, P=0.001). A positive correlation was also observed between the benefits of empathy and academic buoyancy (r=0.36, P=0.001). Furthermore, a significant positive correlation existed between academic buoyancy and academic well-being (r=0.59, P=0.001), along with significant indirect paths through academic buoyancy to academic well-being (P=0.010).Conclusions: The study findings supported the goodness of fit of the proposed model, suggesting its potential utility in developing interventions to enhance students’ academic well-being.

Abstract Background Avian leukosis virus Subgroup-J (ALV-J) is a rapidly oncogenic evolving retrovirus infecting a variety of avian species; causing severe economic losses to the local poultry industry. Methods To investigate ALV-J, a total of 117 blood samples and 57 tissue specimens of different organs were collected for virological, and pathological identification, serological examinations, molecular characterization, and sequencing analysis. To the best of our knowledge, this is the first detailed report recorded in broiler flocks in Egypt. The present study targets the prevalence of a viral tumor disease circulating in broiler flocks in the El-Sharqia, El-Dakahliya, and Al-Qalyubiyya Egyptian governorates from 2021 to 2023 using different diagnostic techniques besides ALV-J gp85 genetic diversity determination. Result We first isolated ALV-J on chicken embryo rough cell culture; showing aggregation, rounding, and degeneration. Concerning egg inoculation, embryonic death, stunting, and curling were observed. Only 79 serum samples were positive for ALV-J (67.52%) based on the ELISA test. Histopathological investigation showed tumors consist of uniform masses, usually well-differentiated myelocytes, lymphoid cells, or both in the liver, spleen, and kidneys. Immunohistochemical examination showed that the myelocytomatosis-positive signals were in the spleen, liver, and kidney. The PCR assay of ALV-J gp85 confirmed 545 base pairs with only 43 positive samples (75.4%). Two positive samples were sequenced and submitted to the Genbank with accession numbers (OR509852–OR509853). Phylogenetic analysis based on the gp85 gene showed that the ALV-J Dakahlia-2 isolate is genetically related to ALV-EGY/YA 2021.3, ALV-EGY/YA 2021.4, ALV-EGY/YA 2021.14, and ALV-EGY/YA 2021.9 with amino acid identity percentage 96%, 97%; 96%, 96%; respectively. Furthermore, ALV-J Sharqia-1 isolate is highly genetically correlated to ALV-EGY/YA 2021.14, and ALV-EGY/YA 2021.9, ALV-J isolate QL1, ALV-J isolate QL4, ALV-J isolate QL3, ALV-EGY/YA 2021.4 with amino acid identity percentage 97%, 97%; 98%, 97%, 97%, 95%; respectively. Conclusions This study confirmed that ALV-J infection had still been prevalent in broilers in Egypt, and the genetic characteristics of the isolates are diverse.

Abstract This study involves the development of a new nanocomposite material for use in biological applications. The nanocomposite was based on tragacanth hydrogel (TG), which was formed through cross-linking of Ca2+ ions with TG polymer chains. The utilization of TG hydrogel and silk fibroin as natural compounds has enhanced the biocompatibility, biodegradability, adhesion, and cell growth properties of the nanobiocomposite. This advancement makes the nanobiocomposite suitable for various biological applications, including drug delivery, wound healing, and tissue engineering. Additionally, Fe3O4 magnetic nanoparticles were synthesized in situ within the nanocomposite to enhance its hyperthermia efficiency. The presence of hydrophilic groups in all components of the nanobiocomposite allowed for good dispersion in water, which is an important factor in increasing the effectiveness of hyperthermia cancer therapy. Hemolysis and 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assays were conducted to evaluate the safety and efficacy of the nanobiocomposite for in-vivo applications. Results showed that even at high concentrations, the nanobiocomposite had minimal hemolytic effects. Finally, the hyperthermia application of the hybrid scaffold was evaluated, with a maximum SAR value of 41.2 W/g measured in the first interval.

Abstract Background Taxi drivers in a Chinese megacity are frequently exposed to traffic-related particulate matter (PM2.5) due to their job nature, busy road traffic, and urban density. A robust method to quantify dynamic population exposure to PM2.5 among taxi drivers is important for occupational risk prevention, however, it is limited by data availability. Methods This study proposed a rapid assessment of dynamic exposure to PM2.5 among drivers based on satellite-derived information, air quality data from monitoring stations, and GPS-based taxi trajectory data. An empirical study was conducted in Wuhan, China, to examine spatial and temporal variability of dynamic exposure and compare whether drivers’ exposure exceeded the World Health Organization (WHO) and China air quality guideline thresholds. Kernel density estimation was conducted to further explore the relationship between dynamic exposure and taxi drivers’ activities. Results The taxi drivers’ weekday and weekend 24-h PM2.5 exposure was 83.60 μg/m3 and 55.62 μg/m3 respectively, 3.4 and 2.2 times than the WHO’s recommended level of 25 µg/m3. Specifically, drivers with high PM2.5 exposure had a higher average trip distance and smaller activity areas. Although major transportation interchanges/terminals were the common activity hotspots for both taxi drivers with high and low exposure, activity hotspots of drivers with high exposure were mainly located in busy riverside commercial areas within historic and central districts bounded by the “Inner Ring Road”, while hotspots of drivers with low exposure were new commercial areas in the extended urbanized area bounded by the “Third Ring Road”. Conclusion These findings emphasized the need for air quality management and community planning to mitigate the potential health risks of taxi drivers.

Traumatic brain injury (TBI) is a global health challenge; however, penetrating brain injury (PBI) remains under-represented in evidence-based knowledge and research efforts. This study utilized data from the Trauma Quality Improvement Program (TQIP) of the National Trauma Data Bank (NTDB) to investigate outcomes of PBI as compared with clinical-severity-matched non-penetrating or blunt TBI. A total of 1765 patients with PBI were 1:1 propensity score-matched for clinical severity with blunt TBI patients. The intent of PBI was self-inflicted in 34.1% of the cases, and the mechanism was firearm-inflicted in 89.1%. Mortality was found to be significantly more common in PBI than in the severity- matched TBI cohort (33.9% vs. 14.3 %, p?0.001) as was unfavorable outcome. Mortality was mediated by withdrawal of life-sustaining therapies (WOLST) 30% of the time, and WOLST occurred earlier (median 3 days vs. 6 days, p?

Penelitian ini merupakan penelitian pengembangan yang bertujuan untuk mengembangkan LKS berbasis PBL berbantuan GeoGebra untuk meningkatkan kemampuan pemecahan masalah dan kesadaran metakognitif siswa yang memenuhi aspek valid, praktis dan efektif. Model penelitian menggunakan model ADDIE, yaitu analysis, design, development, implementation, dan evaluation. Subjek penelitian berjumlah 32 siswa MTs Negeri 8 Ciamis. Instrumen penelitian meliputi angket penilaian kepraktisan guru dan siswa, lembar observasi keterlaksanaan pembelajaran, tes kemampuan pemecahan masalah dan angket kesadaran metakognitif. Hasil penelitian menunjukkan bahwa (1) LKS berbasis PBL berbantuan GeoGebra yang dikembangkan memenuhi aspek valid dengan kriteria “Sangat Baik”, (2) LKS berbasis PBL berbantuan GeoGebra yang dikembangkan memenuhi aspek praktis dengan kriteria “Sangat Baik”, (3) LKS berbasis PBL berbantuan GeoGebra yang dikembangkan memenuhi aspek efektif dimana hasil tes kemampuan pemecahan masalah dianalisis menggunakan uji one sampel t-test. Pada tahap ini diperoleh nilai rata-rata angket siswa lebih dari 75 sehingga disimpulkan bahwa LKS berbasis PBL berbantuan GeoGebra efektif untuk meningkatkan kemampuan pemecahan masalah dan kesadaran metakognitif siswa. Berdasarkan hasil yang diperoleh dapat disimpulkan bahwa LKS berbasis PBL berbantuan GeoGebra yang dikembangkan memenuhi aspek kevalidan, kepraktisan dan keefektifan. GeoGebra-assisted PBL to improve students' problem-solving skills and metacognitive awareness that meet the valid, practical and effective aspects. The research model uses the ADDIE model, namely analysis, design, development, implementation, and evaluation. The research subjects were 32 students of MTs Negeri 8 Ciamis. The research instruments included teacher and student practicality assessment questionnaires, learning implementation observation sheets, problem solving ability tests and metacognitive awareness questionnaires. The results showed that (1) the developed GeoGebra-assisted PBL-based LKS met the valid aspects with the criteria of "Very Good", (2) the developed GeoGebra-assisted PBL-based LKS met the practical aspects with the criteria of "Very Good", (3) PBL-based worksheets assisted by GeoGebra developed meet the effective aspects where the results of the problem solving ability test analyzed using the one sample t-test. At this stage, the student questionnaire was more than 75, so it is concluded that the PBL-based LKS assisted by GeoGebra is effective for improving students' problem solving skills and metacognitive awareness. Based on the results obtained, it can be concluded that the developed GeoGebra-assisted PBL-based worksheet meets the aspects of validity, practicality and effectiveness.

Abstract α-Glucosidase inhibitors have emerged as crucial agents in the management of type 2 diabetes mellitus. In the present study, a new series of coumarin-linked 2-phenylbenzimidazole derivatives 5a–m was designed, synthesized, and evaluated as anti-α-glucosidase agents. Among these derivatives, compound 5k (IC50 = 10.8 µM) exhibited a significant inhibitory activity in comparison to the positive control acarbose (IC50 = 750.0 µM). Through kinetic analysis, it was revealed that compound 5k exhibited a competitive inhibition pattern against α-glucosidase. To gain insights into the interactions between the title compounds and α-glucosidase molecular docking was employed. The obtained results highlighted crucial interactions that contribute to the inhibitory activities of the compounds against α-glucosidase. These derivatives show immense potential as promising starting points for developing novel α-glucosidase inhibitors.

В данной статье представлено аналитическое исследование особенностей двух типов парсинга, а именно синтаксический анализ составляющих (constituency parsing) и синтаксический анализ зависимостей (dependency parsing). Также в рамках проведенного исследования разработан алгоритм оптимизации извлечения ключевых слов, отличающийся применением функции извлечения именных фраз, предоставляемой парсером, для фильтрации неподходящих фраз. Алгоритм реализован с помощью трех разных парсеров: SpaCy, AllenNLP и Stazna. Эффективность предложенного алгоритма сравнивалась с двумя популярными методами (Yake, Rake) на наборе данных с английскими текстами. Результаты экспериментов показали, что предложенный алгоритм с парсером SpaCy превосходит другие алгоритмы извлечения ключевых слов с точки зрения точности и скорости. Для парсера AllenNLP и Stanza алгоритм так же отличается точностью, но требует гораздо большего времени выполнения. Полученные результаты позволяют более детально оценить преимущества и недостатки изучаемых в работе парсеров, а также определить направления дальнейших исследований. Время работы парсера SpaCy значительно меньше, чем у двух других парсеров, потому что парсеры, которые используют переходы, применяют детерминированный или машинно-обучаемый набор действий для пошагового построения дерева зависимостей. Они обычно работают быстрее и требуют меньше памяти по сравнению с парсерами, основанными на графах, что делает их более эффективными для анализа больших объемов текста. С другой стороны, AllenNLP и Stanza используют модели парсинга на основе графов, которые опираются на миллионы признаков, что ограничивает их способность к обобщению и замедляет скорость анализа по сравнению с парсерами на основе переходов. Задача достижения баланса между точностью и скоростью лингвистического парсера является открытой темой, требующей дальнейших исследований в связи с важностью данной проблемы для повышения эффективности текстового анализа, особенно в приложениях, требующих точности при работе в реальном масштабе времени. С этой целью авторы планируют проведение дальнейших исследований возможных решений для достижения такого баланса.

Abstract Oil-based drilling fluids (OBDFs) are extensively used in the drilling industry due to their superior performance in challenging drilling conditions. These fluids control wellbore stability, lubricate the drill bit, and transport drill cuttings to the surface. One important component of oil-based drilling fluids is the viscosifier, which provides rheological properties to enhance drilling operations. This study evaluates the effectiveness of Claytone-IMG 400, a novel rheological agent, in enhancing the performance of OBDFs under high-pressure and high-temperature (HPHT) conditions. A comparative analysis was conducted with a pre-existing organoclay (OC) to assess the improvements achieved by Claytone-IMG 400. The OCs were analyzed using X-ray diffraction (XRD), X-ray fluorescence (XRF), scanning electron microscopy (SEM), and particle size distribution (PSD) to identify their mineral and chemical compositions, morphologies, and particle sizes. The drilling fluid density, electrical stability, sagging tendency, rheological properties, viscoelastic properties, and filtration properties were studied to formulate a stable and high-performance drilling fluid. The results confirmed that the novel OC does not affect the drilling fluid density but enhances the emulsion stability with a 9% increment compared with the drilling fluid formulated with MC-TONE. The sagging experiments showed that Claytone-IMG 400 prevented the sagging issues in both static and dynamic conditions. Also, Claytone-IMG 400 improved the plastic viscosity (PV), yield point (YP), and apparent viscosity (AV). The PV, YP, and AV were improved by 30%, 38%, and 33% increments respectively compared with the drilling fluid formulated with MC-TONE. The YP/PV ratio increased with a 6% increment from 1.12 to 1.19. Moreover, the gel strength (GS) was significantly increased, and the filtration properties were enhanced. The filtration volume was reduced by 10% from 5.0 to 4.5 cm3, and the filter cake thickness had a 37.5% reduction from 2.60 to 1.89 mm. The novelty of this study is highlighted by the introduction and evaluation of Claytone-IMG 400 as a new rheological additive for safe, efficient, and cost-effective drilling operations. The results indicate that Claytone-IMG 400 significantly improves the stability and performance of OBDFs, thereby reducing wellbore instability and drilling-related problems.

Background Child stunting is a significant challenge for most districts in Rwanda and much of sub-Saharan Africa and persists despite multisectoral efforts. There is a notable lack of population-based studies examining the correlation between violence against women and child stunting in Rwanda. Objective We aimed to investigate the association between Rwandan women’s exposure to intimate partner violence (IPV) and child stunting in children under 3 years of age. Methods In December 2021, a population-based cross-sectional study was conducted in the Northern Province of Rwanda, including 601 women and their children

Abstract: Algerian literature vividly reflects the people's struggle against French colonization, with poetry and prose that chronicled and celebrated the armed revolution's heroic deeds. Following independence, writers focused on reinforcing Algerian Islamic Arab identity by drawing inspiration from Arab Islamic heritage. This heritage became a central source of inspiration for poets as they sought to shape a new national reality. Algerian poets, after independence, turned to Islamic culture and heritage, which they deeply revered, to revive and embed this heritage into their works. This was part of a broader effort to rebuild and fortify a strong, independent nation. Contemporary Algerian poetry is marked by its themes of struggle, patriotism, and calls for intellectual, social, and political reform. Poets employed Quranic stories and national and popular heritage to construct a genuine Arab Islamic identity, navigating contemporary challenges while adapting positively to other civilizations. Keywords: Algerian Literature, Islamic Identity, Heritage, Algerian Poetry, Contemporary.

The preservation of post-harvest losses of cowpeas constitutes a major challenge for producers worldwide. Therefore, the aim of this work was to investigate the nutritional qualities of cowpea seeds treated with a bio-insecticide formulated from M. charantia leaves extract in association with gum arabic/kaolinite composite. Three bio-insecticides were formulated using different ethyl acetate, hexane and methanol solvents. These bio-insecticides were obtained by introducing each into a bottle, 10 g of composite in 10 mL of a solution (1 mg/L of extract each extract). However, 5 doses of each formulation (1 %–5 %) were prepared. Each dose of insecticide powders received 20 g of cowpea seeds and then infested with 10 C. maculatus previously starved for 48 h. Then, the biochemical parameters of untreated and treated cowpea seeds using the methanol formulation were evaluated. The obtained results showed that insecticide formulated at 5 % with methanol induced 100 % mortality rate on the second day of treatment with a lethal dose of 0.10 % which is related to its high content of triterpenes and polyphenols. The untreated (UWH) and treated (TWH) seeds without husk have the same contents of ash (2.19 %), proteins (29.14 %), fibers (2.69 %), vitamin C (147.32 mg/100 g) and carbohydrates (53.20 %), while untreated and treated seeds with husk showed the same values in these nutrients even for minerals content. Hence, biochemical analyzes of cowpea seeds treated with the formulated insecticide showed no change in nutritional quality and M. charantia leaves extract in association with gum arabic/kaolinite composite could be used as insect repellent.

A new eco-friendly mesoporous magnetic nanocomposite (MMNCs) known as '' methyl alginate@SBA-15/IONP '' has been created as a nano-adsorbent system for purifying water contaminants. The production process consisted of multiple stages, commencing with the synthesis of Santa Barbara Amorphous-15 (SBA-15) utilizing the hydrothermal approach. Subsequently, Iron oxide nanoparticle (IONP) was prepared onto SBA-15 through an in-situ co-deposition method. Experimental studies were carried out on various factors affecting the adsorption process of Lead (II) ion (Pb2+), Methylene Blue (MB), and Chlorpyrifos (CPS). Furthermore, Langmuir and Freundlich isotherm models, two kinetic models (pseudo-first-order (PFO) and pseudo-second-order (PSO)), and thermodynamic investigations were conducted for the methyl alginate@SBA-15/IONP MMNCs system. Freundlich isotherm model with PSO kinetics describes the adsorption behavior and thermodynamic parameters show the spontaneous and endothermic nature of adsorption of Pb2+, MB, and CPS in methyl alginate @ SBA-15/IONP MMNCs.

AbstractThe inflow of FDI brings many economic benefits including more employment opportunities, sharing of modern knowledge, and the transfer of needed capital to aid the depressing domestic investment. In view of this, the current study aims to find out the empirical impact of the governance quality of the host country on FDI inflow. The empirical analysis was arranged by sampling the 20-year (2000-2019) financial statistics of 8 South Asian economies. For regression assessment, we employ FMOLS and DOLS models and estimate the coefficients in the long run. The empirical analysis discloses the positive significant role of the aggregate governance index on FDI inflow, implying that better governance can uplift the inflow of FDI. In addition, the empirical results disclose the negative impact of the inflation rate, while the significant positive impact of trade volume, population growth, labor force, and financial development on FDI inflow. The empirical analysis yields vital policies both for domestic policy officials and foreign investors. Primarily, it is recommended to focus on improving the governance situation to attract more FDI. This study enriches the literature by showing the interplay between governance and FDI inflow and has equal policy implications for other developing economies of the world.

ABSTRACTBackground: Methamphetamine use disorder (MUD) is associated with poor health outcomes. Pharmacists play a role in delivery of substance use treatment, with several studies having examined their attitudes to people with opioid use disorder, but little is known about their attitude towards people with MUD. This study aimed to explore pharmacists’ perspectives on the provision of services to clients with MUD.Methods: A convenience sampling strategy was used to recruit community pharmacists across Sydney, Australia. Semi structured interviews examined views and ideas of pharmacists surrounding the treatment and management of MUD, followed by coding of transcribed interview data by all members of the research team.Results: Nineteen pharmacists completed the interviews. The main theme identified was stigma held by healthcare professionals. The almost unanimous perception amongst pharmacists was fear and apprehension towards people with MUD, including underlying assumptions of criminality, misinformation regarding people with MUD, and lack of education and knowledge surrounding MUD.Conclusion: A substantial amount of stigma towards people with MUD was found in this study. Negative attitudes by healthcare professionals can perpetuate healthcare disparities and impede the accessibility of future treatment programs for people with MUD. Appropriate educational interventions on MUD for pharmacists are needed.

Background: Hospital health service quality is a fundamental component of the health system. Hospital accreditation is a key approach to enhancing this quality, necessitating the correct implementation of processes. Objectives: This study aims to investigate the compliance of the executive processes of Iran’s hospital accreditation program with the requirements of the International Society for Quality in Health Care and to provide corrective solutions. Methods: This qualitative study uses an inductive content analysis technique. A checklist with seven axes was established by extracting and interpreting the requirements of the executive processes from the International Society for Quality in Health Care. By examining existing documents at the Ministry of Health’s Accreditation Office and conducting interviews with managers and experts in the field, challenges in the domain of the executive processes of Iran’s hospital accreditation program were identified using the relevant checklist. Corrective solutions were then gathered through semi-structured interviews with 19 experts, managers, and accreditation field specialists, categorized inductively, and presented using MAXQDA software. Results: Challenges in seven areas were identified, including governance; strategic, operational and financial management; risk management; human resources management; information management; survey and client management; and the granting of accreditation approval. Subsequently, solutions were categorized into five groups encompassing 26 concepts, focusing on reforming macro policies, addressing implementation challenges, fostering appropriate interactions, improving human resource management, and promoting evidence-based decision-making. Conclusions: The Iran hospital accreditation program’s adherence to International Society for Quality in Health Care standards is inadequate. Establishing a semi-autonomous, non-profit accreditation body that operates under government control and ensuring the independence of the accreditation office is essential for achieving higher compliance and receiving certification from International Society for Quality in Health Care.

Under the direction of Salahaddin University in Erbil's College of Agricultural Engineering Sciences, study was carried out to investigate how local quail performed biochemically, histologically, and immune-wise when varied levels of Salvia indica (SI) additive were added at high stocking density. For a 42-day trial, 216 one-week-old local quails were divided into four treatments at random, with three replicates for each treatment, in cages measuring 60 by 30 by 25 centimeters. The following was the design of the feed treatments: Positive control (12 birds/replicate), Negative control 20 birds per replicate at a high stocking density, 20 birds per replicate plus 0.2% of SI additive, and 20 birds per replicate plus 0.4% of SI additive. When compared to a negative control, the results indicated that 0.4% SI supplements with high stocking density produced the best live body weight and weight gain. When compared to positive and negative controls, the cholesterol level of female quails considerably (P

IntroductionDrought, a prevalent consequence of climate change, significantly impacts mental health among farmers. Enhancing psychological resilience is crucial to mitigating these effects. This study aims to explore the concept and factors affecting the psychological resilience of farmers living in drought-affected regions in Iran.MethodThis study utilized a conventional qualitative content analysis method. Twenty-six participants, divided into two groups of experts and farmers, were selected through purposive sampling. Data collection was conducted via in-depth semi-structured interviews. The study adhered to the Consolidated Criteria for Reporting Qualitative Research (COREQ) checklist and was carried out between June 2023 and February 2024.ResultsThe factors affecting the psychological resilience of farmers living in drought-affected regions were categorized into two main categories with nine subcategories. The first category, environmental factors, included economic factors, socio-cultural factors, drought adaptation methods, government policies, and infrastructural factors. The second category, intra-individual factors, comprised personal characteristics, health factors, psychological factors, and perception and knowledge.ConclusionThe study revealed that both environmental and intra-individual factors influence the psychological resilience of farmers during droughts. It is recommended to implement intervention strategies, such as providing training and education on drought adaptation methods and managing agricultural and healthcare expenses. Further research is needed to expand this concept to various disasters and occupational groups in future studies.

تؤثر السكتة الدماغية والدوار التالي لها بشكل كبير على حياة المريض وهي تعتبر من أشيع الأمراض ولها عواقب وخيمة واعاقة شديدة وتكاليف معالجة باهظة. لذا هدفت الدراسة الوصفية الحالية الى تقييم جودة الحياة لدى مرضى المصابين بالدوار التالي للسكتة الدماغية. وذلك عند عينة متاحة مكونه من 40 مريض سكتة دماغية بمشفى تشرين الجامعي باللاذقية.وجمعت البيانات باستخدام استبيان مطور من قبل الباحث، حيث أظهرت الدراسة أكثر من ثلاثة أرباع المرضى 77.5% لديهم جودة حياة عامة بمستوى متوسط, ونسبة قليلة منهم 15% و7% لديهم جودة حياة جيدة وضعيفة على التوالي. وقد أوصت الدراسة على ضرورة التعرف والتنبأ بجودة الحياة لمرضى الدوار التالي للسكتة الدماغية التي يمكن أن يساعد في التشخيص المبكر للمرضى المعرضين للخطر لتعديل هذه العوامل من أجل تحسين جودة حياتهم وإخضاعهم لبرامج تدريبية تأهيلية ودعمهم في عملية تطويرهم لاستراتيجيات تعويض فعالة لتحسين استعادة التكامل والتوازن الحسي المركزي.

A bimetallic cobalt/nickel-based metal-organic framework (MOF), [Co/Ni(μ3-tp)2(μ2-pyz)2], denoted as Co/Ni-MOF, has been successfully prepared by a hydrothermal method. The MOF was prepared by incorporating mixed O− and N− donor ligands, specifically terephthalic acid (tp) and pyrazine (pyz). The Mesoporous Co/Ni-MOF was comprehensively characterized using various analytical methods such as XRD, BET, FT-IR, TGA (23 % char yields), SEM, and EDS analyses. The synthesized mesoporous Co/Ni-MOF was then used to absorb Co (II) from aquatic areas efficiently. Several critical parameters, such as the beginning Co (II) concentration (25–150 mg/L), the effect of pH (2–10), the duration of time (5–30 min), and the amount of adsorbent (0.003–0.02 g), were systematically investigated. Remarkably, the Mesoporous Co/Ni MOF displayed a significant adsorption capacity of 372.66 mg g−1 in the optimum conditions, including pH = 6, amount of adsorbent = 0.003 g, duration of time = 25 min, and beginning Co (II) concentration = 150 mg/L. Adsorption data from the experimental studies of the mesoporous Co/Ni MOF are matched based on the non-linear pseudo-first-order (PSO) kinetic model (R2 = 0.9999), and a chemical process is suggested for chemisorption. Furthermore, the adsorption isotherms of Co (II) heavy metal ions (HMIs) are an excellent fit with the non-linear Temkin, indicating that they explain the sorbent/sorbate interactions concerning the heat of adsorption. It is evident from the thermodynamic parameters that adsorption is a spontaneous and favorable exothermic process. These results highlight the promising adsorption performance and potential applications of the mesoporous Co/Ni-MOF as an effective adsorbent for Co (II) elimination from aquatic areas. Four-cycle regeneration studies were the most effective for the Co (II) under study.

It is necessary to adopt measures to make optimal use of rich sources of solar energy, considering the limit resources of fossil fuels and increasing demand for energy. Using solar collectors is one of the methods to collect solar energy. The aim of this study was an investigation and prediction of the effect of the collector's slope angle and plate type on the collector performance using artificial neural network (ANN) approaches. Two different ANN models, multi-layer perceptron (MLP) and radial basis function (RBF), were applied to predict the performance parameters of solar collectors. The results indicated that the ANN-MLP and ANN-RBF models were acceptable, but the ANN-RBF model with structure of 2-16-5 had higher acceptability for prediction of output parameters at various input variables. The highest R and lowest root mean square error (RMSE) values in training set of ANN-RBF for air speed (AS) were obtained as 0.984 and 0.015, respectively. The results showed that increasing the slope angle from 0 to 60 caused to increase in the amount of received radiation by the collector, and so leading to an increase in the air temperature inside the collector. On the other hand, the maximum value of thermal power (TP) and collector efficiency (CE) for the porous plate were more than the simple plate by 28.2 % and 41.5 %, respectively.

Background: This study simulates the laminar forced flow of water/silver nanofluid in solid nanoparticle volume fractions ranging from 0 % to 6 % in a microchannel with vortex generators. For Reynolds numbers 100 to 800, the angle of attack of the vortex is changed from 0 to -90° Methods: The finite volume method is used for the 2D numerical study. Increasing the angle of attack leads to greater local flow mixing, which diffuses heat towards the upper parts of the flow, resulting in a favorable microchannel temperature distribution. During the movement of the fluid, the temperature difference between the surface and the fluid decreases. In addition to local friction, shear stress is also responsible for the friction factor. If the Reynolds number is high and the angle of attack is -30°, then the Nusselt number becomes significant. After passing the vortex generators, the effective flow area is higher, which is due to the higher effective flow area. Among the studied cases, the highest friction occurs for an angle of attack of -90° Significant findings: For higher volume fractions of nanoparticles (φ), the effect of fluid velocity dissipation and friction factor variations are higher. To limit entropy generation, higher Reynolds numbers and nanoparticle concentrations could be used. Changing the vortex generator angle has a limited influence on the entropy generation.

The amount of fossil fuel usage in compression ignition (CI) engines is greatly reduced when biodiesel is used. The primary disadvantage of using biodiesel is that, due to its high viscosity, which causes fuels to remain unburned during the premixed combustion stage, leads to lower brake thermal efficiency (BTE). Gaseous fuels predominantly reducing emissions in CI engines due to its complete burning without leaving any carbon traces. Fuel injection pressure (FIP) is one of the factors which is influencing the combustion phase because they are used to optimize fuel particle atomization. The current study examines engine parameters for a dual fuel engine that runs on biodiesel blends made from 20 % methyl ester of chlorella protothecoides micro algae (B20MEOA) and acetylene gas under variable Fuel injection pressure (FIP) ranging from 200 bar to 240 bar with 10-bar steps. According to the experimental results, when 3 LPM of acetylene gas is supplied along with the intake air and B20MEOA supplied at a FIP of 240 bar, the emissions such as smoke opacity, hydrocarbon (HC), and carbon monoxide (CO) are reduced by 16.9 %, 8.3 %, and 15.4 %, respectively, whereas the oxides of nitrogen (NOx) increases by approximately 7 % when compared to B20MEOA alone operation.

This paper seeks to improve through esterification the efficiency of triethanolamine (TEA) molecules used in the cement grinding industry. The unmodified and modified-TEAs are tested at 0.025 % to 0.1 % rates to determine their effect on clinker grindability and cement properties including fineness, flow, zeta potential, morphology, rheology, setting, and compressive strength. Test results showed that the esterification reactions performed to modify the TEA hydroxyl groups can remarkably increase their adsorption potentials onto the clinker grains, which reduces the agglomeration phenomenon and grinding energy consumption by 6 % to 13 %. The TEA modified using medium hydrocarbon chain lengths (4–8 carbons) of mono-carboxylic acid compounds performed better than the one containing short hydrocarbon chain lengths (1–3 carbons). The pastes and mortars prepared using the modified-TEA cements exhibited significantly higher fluidity, better compatibility with polycarboxylate-based superplasticizer, and increased strengths than the equivalent mixtures made using cement ground using the unmodified TEA molecules.

This article presents a comprehensive theoretical study of the electronic properties of tin oxide (SnO2), with a particular focus on its band structure and carrier mobility. Through the utilization of density functional theory (DFT) and advanced computational methods, we delve into the intricacies of the electronic behavior of SnO2 . By solving the Schrödinger equation and the Kohn-Sham equation, we calculate the electronic energy eigenvalues and wave functions, which provide valuable insights into the band structure, effective mass, and carrier mobility of SnO2. Our findings contribute to a solid theoretical foundation for further experimental investigations and technological advancements in this field. In this study, we analyze the calculated band structure of SnO2 to determine the dispersion relationship between energy and wave vector in the Brillouin zone, shedding light on the nature of the bandgap, whether it is direct or indirect. Additionally, we investigate the valence band maxima and conduction band minima, crucial for understanding the transport of electrons and holes in SnO2. The results of our theoretical investigation reveal that SnO2 exhibits a well-defined bandgap, indicating its potential for effective control of electron and hole flow, thus making it suitable for diverse electronic applications. Moreover, the low effective masses of charge carriers in SnO2 facilitate their mobility, contributing to efficient charge transport within the material and enabling the development of high-performance electronic devices. By expanding our understanding of SnO2 electronic properties through theoretical investigations, we establish a solid foundation for further experimental studies and technological advancements in the field. The favorable electronic behavior of tin oxide paves the way for the development of advanced electronic devices, including optoelectronics, sensors, and energy devices, harnessing the unique characteristics of SnO2.

Polycystic ovary syndrome (PCOS) has a high predisposition to many cardiometabolic risk factors that increase susceptibility to severe complications of COVID-19 and also exhibit an increased likelihood of subfertility. Therefore, women with polycystic ovary syndrome may be disproportionately affected by this epidemic and its related consequences. The accumulation of extra body fat that has the possibility of affecting health is referred to as obesity, which is the outcome of an imbalance between energy intake and expenditure, whereby more calories are consumed than are expended through exercise. This study investigated the relationship between angiotensin-converting enzyme 2 and insulin resistance and other parameters in PCOS patients with COVID-19 infection. The study groups comprised 120 sample ladies, involving 80 PCOS patients with and without COVID-19 and 40 control ladies. The leading group of patients was divided into subgroups based on BMI. Blood samples were taken from Kamal-Al-Samarai Hospital between December 2021 and June 2022. Some biochemical parameters were measured for all study groups, which included serum ACE2, D-dimer, lipid profile, GST activity, FBS, and hormones. PCOS women had a higher BMI, FBS, lipid profile (except high-density lipoprotein), D-dimer, waist/hip ratio, testosterone, insulin, and HOMA-IR (p < 0.0001). While GST-activity and ACE2 levels were lower in PCOS (p < 0.001), suggesting that PCOS women are at risk for cardiovascular diseases, In the current research, we found there is a probable relationship between ACE2 and HOMA IR in PCOS patients who have a coronavirus infection.

Background: This work used spectral domain optical coherence tomography (SD-OCT) to assess the macular thickness asymmetry as a diagnostic marker of early glaucoma. Measurements of the thickness of the macula's superior and inferior quadrants as well as the overall thickness of macular ganglion cells will be used to do this. Objectives: The main goal of the study was to use OCT to detect early occurrences of glaucoma in students at Sohag University who had normal or rising IOP. Patients and Method: Case-control study patients and methodology There were 127 participants in this study, or 200 eyes total. 100 people in (Group 1) had early primary open angle glaucoma (cases) (100 eyes) with glaucomatous visual field abnormalities and/or signs of glaucomatous optic neuropathy (GON). With regard to ( Group 2), there were 73 glaucoma-free, healthy controls (controls) with 100 eyes who were unharmed in their visual fields. Results: There is a significant difference in age, total GCL, superior GCL, and inferior GCL between early glaucoma cases and normal cases (P value = 0.000). Early glaucoma cases also had lower levels of total GCL, superior GCL, and inferior GCL. Age and total GCL have a weakly negative connection (r= -.158, P = 0.001), which is weakly negative. In binary logistic regression, Inferior GCL (P value 0.001), Superior GCL (P value = 0.004), and Total GCL (P value = 0.03) are the three variables that affect glaucoma the most. Conclusion: As a result, macular scans are a useful diagnostic tool for detecting early glaucoma. Age-related changes in the thickness of many retinal layers should also be taken into account when interpreting data on retinal layer and RNFL thickness in research examining the impact of disease on the retina.

El objetivo de este trabajo es esbozar un marco de referencia para conocer cuáles son los tipos y los elementos que comprenden un programa basado en inteligencia artificial (IA), esto permitirá formular propuestas de aplicación en el campo de la Bibliotecología y los estudios de la información, pues, aunque desde hace tiempo se reflexiona y analiza el uso de la IA, no hay casos de aplicaciones concretas. El empleo de la IA es habitual en muchas de las aplicaciones y tareas diarias, aunque ello no sea percibido de manera directa. Entonces, el propósito es analizar la IA desde un proceso de aplicación y continuidad a fin de aprovecharla como herramienta sin que su implementación conlleve la pérdida de algunas actividades profesionales o su reemplazo por programas que las automaticen. La propuesta es enfocarse en las posibilidades brindadas por la IA al ámbito bibliotecario y a los estudios de la información, que conducen a una búsqueda continua de aplicaciones en apoyo de la profesión del bibliotecario y la investigación en este campo. Asimismo, se advierten las habilidades que adquieren los profesionales de la información ante los contextos y las posibilidades de aplicación.

It is known that the devastating earthquakes experienced in Türkiye in recent years have caused significant loss of life and structural damage throughout the country. Especially the large-scale earthquakes that occurred in Kahramanmaraş on February 6, 2023 and the effects of these earthquakes are examined in detail by researchers. In post-earthquake inspections, it is emphasized that structures such as hospitals and water tanks that need to provide emergency services after the earthquake should be examined in detail and that these structures should be earthquake resistant. In this study, while material-related damages in the structures in the regions affected by the Kahramanmaraş earthquake are examined, the importance of structural improvements, especially in order to increase the earthquake resistance of water tanks, is emphasized. It was also stated that the reasons for the building collapses that occurred after the earthquake in Hatay were discussed in detail. This study makes a valuable contribution to increasing the durability of structures in earthquake risk areas.

The reason for conducting this research was to examine asphalt mixtures and the influence of additives obtained from recycled Polyethylene Terephthalate (PET) on their mechanical properties. Due to this, after the chemical recycling of PET, the substance resulting from the chemical reaction was added to the asphalt binder in different contents. In order to evaluate the mechanical performance of mixtures containing additives, a variety of different mechanical tests were carried out. In order to accomplish this goal, tests including dynamic creep, indirect tensile strength (ITS), and indirect tensile modulus (IDTM) were carried out to determine rutting, moisture susceptibility, and resilient modulus, respectively. The SCB test is used to determine how well a material resists cracking when subjected to low temperatures. The results showed that the addition of an additive derived from recycled PET could increase the rutting resistance, significantly improve resistance against moisture damage and increase cracking resistance at low temperatures. In accordance with the findings of the indirect tensile strength tests, indirect tensile modulus and SCB was the best performance related to the asphalt mixture containing 2% recycled PET. However, this result was different in the dynamic creep test, and the asphalt mixture containing 1% additive showed the best performance. The results of data analysis with one-way analysis of variance showed that all the data obtained in this study are statistically significant considering the confidence factor of 95%, so it can be said that the addition of recycled PET additive has a significant effect on the mechanical properties of the asphalt mixture.

Aims •To identify current practices regarding baseline tests monitoring for antipsychotic medications. •To identify potential causes for not adhering to the standard guidelines. •To ensure all the baseline tests have been documented and reviewed properly. Methods In a retrospective analysis, a cohort of 28 patient case notes was examined in June 2023 to assess the baseline physical health parameters within the Psychiatry department at Punjab Institute of Mental Health, Lahore, in accordance with the guidelines outlined in “The Maudsley Prescribing Guidelines in Psychiatry 13th edition.” The data was analyzed to fulfill the audit objectives, and significant trends were subsequently identified. Results The baseline assessments encompassed a comprehensive blood count, urea and electrolyte analysis, liver function testing, blood glucose measurement, and blood pressure monitoring, all of which were conducted in 100% of the cases. Nevertheless, electrocardiography (ECG) was only carried out in 71% of the cases prior to the initiation of antipsychotic treatment. Regrettably, there was a lack of documentation regarding baseline weight/BMI monitoring, serum prolactin level assessment, and creatinine phosphokinase level measurement. Conclusion The audit revealed several areas of concern that warrant immediate attention and improvement. These include: •Protocols and Guidelines: The absence of defined protocols poses a significant challenge to maintaining consistent and standardized practices within the department. •Awareness and Training: There is a noticeable lack of awareness among medical staff, including doctors and nurses, regarding the importance and proper procedures for baseline assessments. •Sampling Errors: The occurrence of sampling errors during the data collection process has impacted the reliability and accuracy of the obtained results. •Administrative Challenges: Administrative issues have been identified as a barrier to the seamless implementation of baseline assessment protocols. •Resource Allocation: Insufficient funding for laboratory resources has hindered the comprehensive and timely conduct of essential tests. •Test Availability: The limitations in the availability of certain required tests have impeded the thoroughness of baseline assessments for patients. Addressing these areas of improvement is critical to enhancing the quality of care and ensuring the holistic well-being of our patients. It is imperative to implement robust protocols, enhance staff awareness and training, rectify administrative challenges, secure adequate funding for resources, and ensure the availability of essential tests. These measures will contribute to the delivery of comprehensive and effective healthcare services within the Psychiatry department at Punjab Institute of Mental Health, Lahore.

Objectives: This study aimed to do a comprehensive systematic review on the comparison of digital and conventional workflows regarding prosthetic outcomes, accuracy of implant impressions, framework passivity and fit, and clinical fabrication of multi-unit implant-supported fixed restorations. Materials and Methods: The EMBASE, PubMed, Scopus, and Cochrane Library databases were searched for relevant articles published up until April 2020. Results: No in-vivo article was found to compare full digital and conventional workflows regarding the accuracy of implant impressions, passivity and fit of frameworks, and prosthetic outcomes. There was no study to investigate full digital and conventional workflows for clinical fabrication of multi-unit implant-supported fixed restorations. Conclusion: This empty review highlights the need for further research to compare full digital and conventional workflows for implant-supported restorations.

This study aimed to examine the impact of propolis (Pro) on various physiological parameters in male rats experiencing induced testicular dysfunction by Bisphenol A. Five groups of ten male rats apiece were created by random selection from the rats. Group 1 the rats, which performed as the group under negative control, received normal food and water. In Group 2, rats were subjected to intraperitoneal administration of 0.2 mL of corn oil, utilized as the vehicle for bisphenol A (BPA), thereby serving as the vehicle control group. For Group 3, rats were administered in corn oil, BPA dissolved at a dosage of 50 mg/kg body weight administered three times a week for three weeks using an intraperitoneal injection. In Group 4rats received a dose of 250 mg/kg body weight of propolis (protected) orally via a gavage needle. Subsequently, intraperitoneal injections are administered to them from BPA delivered three times weekly for three weeks, the dosage is 50 mg per kilogram of body weight dissolved in corn oil. In Group 5, rats received protection with vitamin E orally, at a dose of 100 mg/kg body weight, using a gavage needle. The intraperitoneal injection of BPA, dissolved in corn oil at a dose of 50 mg/kg body weight, was then given three times a week for three weeks. After three weeks, animals were sacrificed, and testes and blood were gathered for additional analysis. Superoxide Dismutase (SOD), Sperm Viability, General motility, Progressive motility, and Morphology, were all significantly reduced in the BPA group compared to the control groups, according to the results. While malondialdehyde (MDA) increased in the BPA group compared to the control groups. In conclusion, propolis enhanced physiological parameters adversely affected by BPA, suggesting its potential as a protective agent against BPA-induced testicular dysfunction.