115 results on '"Alain Carrié"'
Search Results
102. P280 LDL-APHERESIS SELECTIVELY INDUCES CHANGES IN THE LIPIDOME AND PROTEOME OF APO-AI-CONTAINING LIPOPROTEIN PARTICLES IN FAMILIAL HYPERCHOLESTEROLEMIA
- Author
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Alain Carrié, M. Atassi-Dumont, Dominique Bonnefont-Rousselot, Geesje M. Dallinga-Thie, Maryse Guerin, Anatol Kontush, Johannes H.M. Levels, Eric Bruckert, Martine Couturier, Alexina Orsoni, M J Chapman, and Samir Saheb
- Subjects
medicine.medical_specialty ,business.industry ,General Medicine ,Familial hypercholesterolemia ,Lipidome ,medicine.disease ,Endocrinology ,LDL apheresis ,Internal medicine ,Proteome ,Internal Medicine ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Lipoprotein - Published
- 2010
103. MS35 SMALL, DENSE HDL3 PARTICLES EXHIBIT DEFECTIVE ANTIOXIDATIVE AND ANTIINFLAMMATORY FUNCTION IN FAMILIAL HYPERCHOLESTEROLEMIA: PARTIAL CORRECTION BY LDL-APHERESIS
- Author
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M. Atassi, Alexina Orsoni, Paul Robillard, M J Chapman, Eric Bruckert, Martine Couturier, S. Chantepie, P. Thérond, Samir Saheb, H. Hussein, Anatol Kontush, and Alain Carrié
- Subjects
medicine.medical_specialty ,Endocrinology ,LDL apheresis ,business.industry ,Internal medicine ,Internal Medicine ,medicine ,General Medicine ,Familial hypercholesterolemia ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Function (biology) - Published
- 2010
104. W05-O-001 Genetic polymorphism in the organic anion transporter polypeptide-C gene: A determinant factor in statin response?
- Author
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Alain Carrié, Philippe Giral, Eric Bruckert, A. Raisonnier, Sylvie Dejager, and John Chapman
- Subjects
Genetics ,Statin ,Organic anion transporter 1 ,biology ,C-peptide ,medicine.drug_class ,General Medicine ,chemistry.chemical_compound ,Polymorphism (materials science) ,chemistry ,Biochemistry ,Internal Medicine ,biology.protein ,medicine ,Cardiology and Cardiovascular Medicine ,Gene ,A determinant - Published
- 2005
105. Genetic and allelic heterogeneity of LGMD in North Africa
- Author
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F. El Kerch, Aziza Sbiti, K. Azibi, F. Leturcq, Marc Jeanpierre, F. Piccolo, A. Reghis, J.-C. Kaplan, Cherif Beldjord, M. Chaouch, Abdelaziz Sefiani, and Alain Carrié
- Subjects
Neurology ,Evolutionary biology ,Pediatrics, Perinatology and Child Health ,North africa ,Allelic heterogeneity ,Neurology (clinical) ,Biology ,Genetics (clinical) - Published
- 1997
106. Genetic, allelic and phenotypic heterogeneity of muscular dystrophies with primary and secondary involvement of adhalin (alpha-sarcoglycan)
- Author
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Jacques S. Beckmann, Alain Carrié, Marc Jeanpierre, Luciano Merlini, Michel Fardeau, J.-C. Kaplan, F. Piccolo, Fernando M.S. Tomé, Kevin P. Campbell, Cherif Beldjord, A. Sefiani, Caroline Sewry, C. de Toma, N. Rornero, M. Chaouch, T. Voit, K. Azibi, F. Leturcq, and Yoshihide Sunada
- Subjects
Genetics ,Neurology ,Genetic heterogeneity ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,Allele ,Biology ,Alpha-Sarcoglycan ,Genetics (clinical) - Published
- 1996
107. NOTAS DE INVESTIGACIÓN SOBRE JUVENTUD, CULTURA Y EDUCACIÓN: EL RELATO DE LOS ACTORES
- Author
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MARCEL THEZÁ, JORGE CASTILLO, EDUARDO CANDIA, and ALAIN CARRIER
- Subjects
Social sciences (General) ,H1-99 ,Communities. Classes. Races ,HT51-1595 - Abstract
El presente trabajo propone una revisión de un conjunto de fenómenos analizados en el marco del estudio «Juventud, cultura y educación» del Ministerio de Educación de Chile y de la Fundación Sistema de España. Concentrándose en la fase cualitativa de dicho estudio, se describen los aspectos más relevantes del relato juvenil en torno a las áreas de: a) caracterización y valores de los jóvenes; b) participación y ciudadanía y c) tendencias educativas. De igual forma, este trabajo finaliza sugiriendo una agenda tematizada de investigación que pueda profundizar ciertas dimensiones que este estudio no logró abordar a cabalidad, dada las restricciones propias de su naturaleza y propósito.
- Published
- 2013
108. Impact of LDL apheresis on atheroprotective reverse cholesterol transport pathway in familial hypercholesterolemia
- Author
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Alexina Orsoni, Elise F. Villard, Eric Bruckert, Paul Robillard, Alain Carrie, Dominique Bonnefont-Rousselot, M. John Chapman, Geesje M. Dallinga-Thie, Wilfried Le Goff, and Maryse Guerin
- Subjects
cholesteryl ester transfer protein ,low density lipoprotein ,high density lipoprotein ,cellular cholesterol efflux ,high density lipoprotein cholesteryl ester uptake ,Biochemistry ,QD415-436 - Abstract
In familial hypercholesterolemia (FH), low HDL cholesterol (HDL-C) levels are associated with functional alterations of HDL particles that reduce their capacity to mediate the reverse cholesterol transport (RCT) pathway. The objective of this study was to evaluate the consequences of LDL apheresis on the efficacy of the RCT pathway in FH patients. LDL apheresis markedly reduced abnormal accelerated cholesteryl ester transfer protein (CETP)-mediated cholesteryl ester (CE) transfer from HDL to LDL, thus reducing their CE content. Equally, we observed a major decrease (−53%; P < 0.0001) in pre-β1-HDL levels. The capacity of whole plasma to mediate free cholesterol efflux from human macrophages was reduced (−15%; P < 0.02) following LDL apheresis. Such reduction resulted from a marked decrease in the ABCA1-dependent efflux (−71%; P < 0.0001) in the scavenger receptor class B type I-dependent efflux (−21%; P < 0.0001) and in the ABCG1-dependent pathway (−15%; P < 0.04). However, HDL particles isolated from FH patients before and after LDL apheresis displayed a similar capacity to mediate cellular free cholesterol efflux or to deliver CE to hepatic cells. We demonstrate that rapid removal of circulating lipoprotein particles by LDL apheresis transitorily reduces RCT. However, LDL apheresis is without impact on the intrinsic ability of HDL particles to promote either cellular free cholesterol efflux from macrophages or to deliver CE to hepatic cells.
- Published
- 2012
- Full Text
- View/download PDF
109. EL TRATADO DE TAPIHUE ENTRE CIERTOS LINAJES MAPUCHES Y EL GOBIERNO DE CHILE [1825] THE TREATY OF TAPIHUE BETWEEN CERTAIN MAPUCHES LINEAGES AND THE GOVERNMENT OF CHILE (1825)
- Author
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Eduardo Téllez L, Osvaldo Silva G, Alain Carrier, and Valeska Rojas C
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Tapihue ,tratados ,chilenos ,mapuches ,límites ,territorio ,Araucanía ,autonomía ,Mariluán ,Barnechea ,Congreso Nacional ,parlamentos ,frontera ,treaties ,Chilean ,Mapuche ,limits ,territory ,Araucania ,autonomy ,Barrenechea ,National Congress ,parliaments ,frontiers ,History America ,E-F ,Latin America. Spanish America ,F1201-3799 - Abstract
El documento reproducido es una copia fotográfica del único texto impreso del Tratado de Tapihue, suscrito el 7 de enero de 1825, por el coronel del ejército patriota y comandante en jefe de la Alta Frontera, Pedro Barnechea, en representación del gobierno de Chile, y el cacique principal de la alianza "llanista", Juan Mariluán; el primero de varios acuerdos de paz llevados a cabo entre la república y las diversas parcialidades mapuches, tras la Independencia. Si bien el contenido del tratado ha sido muy difundido últimamente, nunca se había efectuado una reprografía visual del impreso original, tras su publicación, por orden del Congreso Nacional, en los talleres de la Imprenta Nacional, de Santiago de Chile. Se trata, por consiguiente, de una imagen fidedigna de la versión "oficial" patrocinada por el poder legislativo chileno. Va precedido de una presentación que ilustra al lector sobre los antecedentes que rodearon su edición, redescubrimiento y análisis técnico. Asimismo, se brindan comentarios pertinentes a los alcances jurídicos, antropológicos y políticos de su contenido. Se formula una especial reflexión en torno al estatus político adquirido por el territorio de la Araucanía, uno de los ejes temáticos de este trabajo, derivado de un proyecto Fondecyt relativo al devenir de la sociedad en los orígenes de la república.The document reproduced here is a photographic copy ofthe only printed version of the Tapihue Treaty, signed on January 7, 1825, by the patriot army colonel and commander in chiefofthe High Frontier, Pedro Barnechea, representing the Government ofChile and the principal chiefofthe alliance "llanista" Juan Mariluán,. It was the first ofseveral peace agreement sheld between the republic and the various lineages Mapuche groups after independence. While the content of the treaty has circulated before, a visual reproduction of the original form after being published by order ofCongress, in the workshops ofthe National Printing Office, Santiago de Chile, was not available. It is therefore a reliable picture of the "official" sponsored by the Chilean legislature. It is preceded by a presentation that explains the history surrounding its release, rediscovery and technical analysis. Likewise, this presentation provides comments relevant to the legal scope, anthropological and political content. It makes a special reflection on the political status acquired through the territory ofAraucania, one of the themes of this work, derivedfrom Fondecytproject on the development ofthe Mapuche society at the beginnings ofthe Chilean republic.
- Published
- 2011
110. IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis
- Author
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Margaret E. Graham, Nadia Bahi, Jamel Chelly, Philippe Chafey, Fabien Fauchereau, Robert D. Burgoyne, Jamie L. Weiss, Gaëlle Friocourt, and Alain Carrié
- Subjects
Molecular Sequence Data ,Neuronal Calcium-Sensor Proteins ,Nerve Tissue Proteins ,CHO Cells ,Saccharomyces cerevisiae ,Biology ,PC12 Cells ,Exocytosis ,Homology (biology) ,Cricetinae ,Two-Hybrid System Techniques ,Chlorocebus aethiops ,Genetics ,Animals ,Humans ,5-HT5A receptor ,Amino Acid Sequence ,Calcium Signaling ,Receptor ,Molecular Biology ,Gene ,Genetics (clinical) ,chemistry.chemical_classification ,Sequence Homology, Amino Acid ,Binding protein ,Calcium-Binding Proteins ,Neuropeptides ,Receptors, Interleukin-1 ,General Medicine ,Recombinant Proteins ,Rats ,Amino acid ,Biochemistry ,chemistry ,Neuronal calcium sensor-1 ,Growth Hormone ,COS Cells ,Mental Retardation, X-Linked ,biology.protein ,Calcium ,Interleukin-1 Receptor Accessory Protein ,Interleukin-1 - Abstract
Previously, human genetics-based approaches allowed us to show that mutations in the IL-1 receptor accessory protein-like gene (IL1RAPL) are responsible for a non-specific form of X-linked mental retardation. This gene encodes a predicted protein of 696 amino acids that belongs to a novel class of the IL-1/Toll receptor family. In addition to the extracellular portion consisting of three Ig-like domains and the intracellular TIR domain characteristic of the IL-1/Toll receptor family, IL1RAPL contains a specific 150 amino acid carboxy terminus that has no significant homology with any protein of known function. In order to begin to elucidate the function of this IL-1/Toll receptor-like protein, we have assessed the effect of recombinant IL1RAPL on the binding affinity of type I IL-1R for its ligands IL-1alpha and beta and searched for proteins interacting with the specific carboxy terminus domain of IL1RAPL. Our results show that IL1RAPL is not a protein receptor for IL-1. In addition we present here the identification of Neuronal Calcium Sensor-1 (NCS-1) as an IL1RAPL interactor. Remarkably, although NCS-1 and its non-mammalian homologue, frequenin, are members of a highly conserved EF-hand Ca(2+) binding protein family, our data show that IL1RAPL interacts only with NCS-1 through its specific C-terminal domain. The functional relevance of IL1RAPL activity was further supported by the inhibitory effect on exocytosis in PC12 cells overexpressing IL1RAPL. Taken together, our data suggest that IL1RAPL may regulate calcium-dependent exocytosis and provide insight into the understanding of physiopathological mechanisms underlying cognitive impairment resulting from IL1RAPL dysfunction.
111. MOLECULAR SPECTRUM OF PCSK9-BASED FH IN FRANCE, THE FRENCH P.(SER127ARG) FOUNDER VARIANT
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M. Abi Fadel, Jean-Pierre Rabès, Yara Azar, M. Di-Filippo, Sophie Béliard, Yara Abou-Khalil, Alain Carrié, Catherine Boileau, and Mathilde Varret
- Subjects
Physics ,Genetics ,Cardiology and Cardiovascular Medicine ,Spectrum (topology)
112. Desarrollo nuclear: ¿otoño o primavera para la proliferación en actores estatales?
- Author
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Adela Cubillos, Cristian Garay, Alain Carrier, and Diego Hernandez
- Subjects
Proliferación nuclear ,estados ,seguridad internacional ,International relations ,JZ2-6530 ,Political science (General) ,JA1-92 - Abstract
El presente artículo tiene como objetivo exponer la situación de la proliferación nuclear desde los actores estatales. Por medio del régimen nuclear internacional se analiza el desempeño de los Estados nucleares, la situación de las potencias intermedias y quienes constituyen una amenaza para el sistema internacional. Los ejes destacados en que se profundiza la discusión, son la ampliación del grupo de Estados nucleares, el aumento sostenido de los reactores nucleares en el mundo con el propósito de suplir la alta demanda de energía eléctrica mundial, y la erosión en los hechos del régimen de no proliferación nuclear. Entre las principales conclusiones se argumenta la relación directa entre la Agenda de Seguridad Internacional y el desarrollo de armas nucleares con el objetivo de balancear las relaciones interestatales según las diferentes dinámicas regionales, donde los Estados destinan recursos a investigación y gasto militar con el objetivo de lograr avances tecnológicos, los cuales se constituyen en la base para sustentar sus opciones, intereses y pretensiones en relación al sistema internacional.
- Published
- 2013
- Full Text
- View/download PDF
113. Solución a la mediterraneidad de Bolivia: una propuesta desde Chile
- Author
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Alain Carrier, Eduardo Tellez, and Fernando Villamizar
- Subjects
Tratado de 1904 Chile y Bolivia ,Tratado Antártico ,International relations ,JZ2-6530 ,Political science (General) ,JA1-92 - Abstract
Tras la firma del Tratado de 1904 suscrito entre Chile y Bolivia, este último Estado se quedó sin una salida soberana al océano pacífico. El presente artículo da cuenta de cómo Chile a lo largo del siglo XX ha tenido como política de Estado buscar alguna fórmula para brindarle acceso al mar a Bolivia. Además, este artículo presenta una propuesta para solucionar la mediterraneidad de Bolivia, basada en la experiencia del Tratado Antártico de 1959, y finalmente analiza las relaciones de poder involucradas que facilitarían o impedirían una solución.
- Published
- 2013
- Full Text
- View/download PDF
114. Role of DNA methyltransferase 3a (Dnmt3a) in the adaptation of atherogenesis key players to proatherogenic environment
- Author
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Nabulsi, Maisa, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris VI, Alain Carrié, Philippe Couvert, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and STAR, ABES
- Subjects
Inflammation ,Athérosclérose ,[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,Monocyte/macrophage ,[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,Régulation du cholésterol ,Dnmt3a ,Monocyte/macrophages ,Atherosclerosis ,Environnement - Abstract
DNA methyltransferase 3a (DNMT3A) links environment to phenotypes via catalysis of CpG dinucleotides, notably found in genes promoter regions, methylation and whose hypomethylation is associated with gene transcriptional activation thus enabling the control of gene expression in physiologic and pathologic states. Most of our knowledge about its’ role in disease occurrence are based on articles demonstrating its’ implication in human cancers. Limited data from mouse studies illustrates its’ contribution to certain pathologies. Atherosclerosis constitutes the single most important contributor to the growing burden of cardiovascular disease. Risk factors contribute to disease occurrence, where most are related to environmental influences, notably Dyslipidaemia, a key initiator of atherosclerosis. Abundant data link hypercholesterolemia to atherogenesis, on the other hand, contribution of inflammatory mechanisms that couple dyslipidaemia to atheroma formation has been also appreciated. So far, a growing number of data suggests a role of Dnmt3a in atherosclerosis but to date, its role in cholesterol regulation and early plaque formation has not been clearly elucidated. Our results suggested that deletion of Dnmt3a in monocyte/macrophages does not affect the formation of early atherosclerostic plaque nor does it impact the polarization of macrophages in vitro. In parallel, we have also demonstrated that the deletion of Dnmt3a in hepatocytes leads to significant elevation in TC levels. We were not able to relate this elevation to dysregulation of major genes involved in Cholesterol regulation. On the other hand, we noticed activation of hepatic inflammatory responses., L’ADN méthyltransférase 3a (DNMT3A) relie environnement et phénotype par la méthylation des dinucléotides CpG, qu’on les trouve en particulier dans les régions promotrices des gènes. Hypométhylation de ces CpG est associée à l’activation de la transcription, qui permet le contrôle de l'expression génique dans des états physiologiques et pathologiques. La plupart de nos connaissances sur l’implication de Dnmt3a en pathologie concernent le cancer, quelques données montrent sa contribution à d’autres pathologies. L’athérosclérose est la maladie cardiovasculaire la plus fréquente. Plusieurs facteurs de risque contribuant à son apparition, sont liés à L’environnement. En particulier, les dyslipidémies, largement influencées par le régime alimentaire. Par ailleurs, d’abondantes données décrivent la contribution des cellules inflammatoires à la physiopathologie de cette maladie. Jusqu'à présent, un nombre croissant de données suggère un rôle de la méthylation de l’ADN dans l'athérosclérose, mais à ce jour, le rôle de Dnmt3a dans la régulation du cholestérol et le développement initial des plaques n'a pas été étudié.Nos résultats suggèrent que l’inactivation de Dnmt3a dans les monocytes/macrophages ne modifie pas le développement initial des plaques d’athérome et n’a pas d’influence sur la polarisation des macrophages in vitro. En parallèle, nous avons démontré que l’inactivation de Dnmt3a dans les hépatocytes conduit à une différence significative de cholestérolémie plasmatique qui n’est pas liée à une dérégulation des gènes majeurs impliqués dans le métabolisme du cholestérol. En revanche, nous avons mis en évidence une activation des réponses inflammatoires.
- Published
- 2016
115. Rôle de l'ADN méthyltransférase 3a (Dnmt3a) dans l'adaptation des joueurs clés de l'athérogenèse à l'environnement proathérogène
- Author
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Nabulsi, Maisa, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris VI, Alain Carrié, Philippe Couvert, and STAR, ABES
- Subjects
Inflammation ,Athérosclérose ,[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,Monocyte/macrophage ,[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,Régulation du cholésterol ,Dnmt3a ,Monocyte/macrophages ,Atherosclerosis ,Environnement - Abstract
DNA methyltransferase 3a (DNMT3A) links environment to phenotypes via catalysis of CpG dinucleotides, notably found in genes promoter regions, methylation and whose hypomethylation is associated with gene transcriptional activation thus enabling the control of gene expression in physiologic and pathologic states. Most of our knowledge about its’ role in disease occurrence are based on articles demonstrating its’ implication in human cancers. Limited data from mouse studies illustrates its’ contribution to certain pathologies. Atherosclerosis constitutes the single most important contributor to the growing burden of cardiovascular disease. Risk factors contribute to disease occurrence, where most are related to environmental influences, notably Dyslipidaemia, a key initiator of atherosclerosis. Abundant data link hypercholesterolemia to atherogenesis, on the other hand, contribution of inflammatory mechanisms that couple dyslipidaemia to atheroma formation has been also appreciated. So far, a growing number of data suggests a role of Dnmt3a in atherosclerosis but to date, its role in cholesterol regulation and early plaque formation has not been clearly elucidated. Our results suggested that deletion of Dnmt3a in monocyte/macrophages does not affect the formation of early atherosclerostic plaque nor does it impact the polarization of macrophages in vitro. In parallel, we have also demonstrated that the deletion of Dnmt3a in hepatocytes leads to significant elevation in TC levels. We were not able to relate this elevation to dysregulation of major genes involved in Cholesterol regulation. On the other hand, we noticed activation of hepatic inflammatory responses., L’ADN méthyltransférase 3a (DNMT3A) relie environnement et phénotype par la méthylation des dinucléotides CpG, qu’on les trouve en particulier dans les régions promotrices des gènes. Hypométhylation de ces CpG est associée à l’activation de la transcription, qui permet le contrôle de l'expression génique dans des états physiologiques et pathologiques. La plupart de nos connaissances sur l’implication de Dnmt3a en pathologie concernent le cancer, quelques données montrent sa contribution à d’autres pathologies. L’athérosclérose est la maladie cardiovasculaire la plus fréquente. Plusieurs facteurs de risque contribuant à son apparition, sont liés à L’environnement. En particulier, les dyslipidémies, largement influencées par le régime alimentaire. Par ailleurs, d’abondantes données décrivent la contribution des cellules inflammatoires à la physiopathologie de cette maladie. Jusqu'à présent, un nombre croissant de données suggère un rôle de la méthylation de l’ADN dans l'athérosclérose, mais à ce jour, le rôle de Dnmt3a dans la régulation du cholestérol et le développement initial des plaques n'a pas été étudié.Nos résultats suggèrent que l’inactivation de Dnmt3a dans les monocytes/macrophages ne modifie pas le développement initial des plaques d’athérome et n’a pas d’influence sur la polarisation des macrophages in vitro. En parallèle, nous avons démontré que l’inactivation de Dnmt3a dans les hépatocytes conduit à une différence significative de cholestérolémie plasmatique qui n’est pas liée à une dérégulation des gènes majeurs impliqués dans le métabolisme du cholestérol. En revanche, nous avons mis en évidence une activation des réponses inflammatoires.
- Published
- 2016
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