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A fundamental approach in neuroscience research is to test hypotheses based on neuropsychological and behavioral measures, i.e., whether certain factors (e.g., related to life events) are associated with an outcome (e.g., depression). In recent years, deep learning has become a potential alternative approach for conducting such analyses by predicting an outcome from a collection of factors and identifying the most "informative" ones driving the prediction. However, this approach has had limited impact as its findings are not linked to statistical significance of factors supporting hypotheses. In this article, we proposed a flexible and scalable approach based on the concept of permutation testing that integrates hypothesis testing into the data-driven deep learning analysis. We apply our approach to the yearly self-reported assessments of 621 adolescent participants of the National Consortium of Alcohol and Neurodevelopment in Adolescence (NCANDA) to predict negative valence, a symptom of major depressive disorder according to the NIMH Research Domain Criteria (RDoC). Our method successfully identifies categories of risk factors that further explain the symptom., Comment: Accepted at the 5th workshop on PRedictive Intelligence in Medicine (PRIME 2022) - MICCAI 2022

Translating machine learning algorithms into clinical applications requires addressing challenges related to interpretability, such as accounting for the effect of confounding variables (or metadata). Confounding variables affect the relationship between input training data and target outputs. When we train a model on such data, confounding variables will bias the distribution of the learned features. A recent promising solution, MetaData Normalization (MDN), estimates the linear relationship between the metadata and each feature based on a non-trainable closed-form solution. However, this estimation is confined by the sample size of a mini-batch and thereby may cause the approach to be unstable during training. In this paper, we extend the MDN method by applying a Penalty approach (referred to as PDMN). We cast the problem into a bi-level nested optimization problem. We then approximate this optimization problem using a penalty method so that the linear parameters within the MDN layer are trainable and learned on all samples. This enables PMDN to be plugged into any architectures, even those unfit to run batch-level operations, such as transformers and recurrent models. We show improvement in model accuracy and greater independence from confounders using PMDN over MDN in a synthetic experiment and a multi-label, multi-site dataset of magnetic resonance images (MRIs).

Parkinson's disease (PD) is a neurological disorder that has a variety of observable motor-related symptoms such as slow movement, tremor, muscular rigidity, and impaired posture. PD is typically diagnosed by evaluating the severity of motor impairments according to scoring systems such as the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Automated severity prediction using video recordings of individuals provides a promising route for non-intrusive monitoring of motor impairments. However, the limited size of PD gait data hinders model ability and clinical potential. Because of this clinical data scarcity and inspired by the recent advances in self-supervised large-scale language models like GPT-3, we use human motion forecasting as an effective self-supervised pre-training task for the estimation of motor impairment severity. We introduce GaitForeMer, Gait Forecasting and impairment estimation transforMer, which is first pre-trained on public datasets to forecast gait movements and then applied to clinical data to predict MDS-UPDRS gait impairment severity. Our method outperforms previous approaches that rely solely on clinical data by a large margin, achieving an F1 score of 0.76, precision of 0.79, and recall of 0.75. Using GaitForeMer, we show how public human movement data repositories can assist clinical use cases through learning universal motion representations. The code is available at https://github.com/markendo/GaitForeMer ., Comment: Accepted as a conference paper at MICCAI (Medical Image Computing and Computer Assisted Intervention) 2022

In this study, we propose circularly-shifted chirp (CSC)-based majority vote (MV) (CSC-MV), a power-efficient over-the-air computation (OAC) scheme, to achieve long-range federated edge learning (FEEL). The proposed approach maps the votes (i.e., the sign of the local gradients) from the edge devices (EDs) to the linear CSCs constructed with a discrete Fourier transform-spread orthogonal frequency division multiplexing (DFT-s-OFDM) transmitter. At the edge server (ES), the MV is calculated with an energy detector. We compare our proposed scheme with one-bit broadband digital aggregation (OBDA) and show that the output-power back-off (OBO) requirement of the transmitters with an adjacent-channel-leakage ratio (ACLR) constraint for CSC-MV is lower than the one with OBDA. For example, with an ACLR constraint of -22 dB, CSC-MV can have an OBO requirement of 6-7 dB less than the one with OBDA. When the power amplifier (PA) non-linearity is considered, we demonstrate that CSC-MV outperforms OBDA in terms of test accuracy for both homogeneous and heterogeneous data distributions, without using channel state information (CSI) at the ES and EDs., Comment: 7 pages, 9 figures, to be presented at the "2022 IEEE International Symposium on Personal, Indoor and Mobile Radio Communications"

With the widespread use of sophisticated machine learning models in sensitive applications, understanding their decision-making has become an essential task. Models trained on tabular data have witnessed significant progress in explanations of their underlying decision making processes by virtue of having a small number of discrete features. However, applying these methods to high-dimensional inputs such as images is not a trivial task. Images are composed of pixels at an atomic level and do not carry any interpretability by themselves. In this work, we seek to use annotated high-level interpretable features of images to provide explanations. We leverage the Shapley value framework from Game Theory, which has garnered wide acceptance in general XAI problems. By developing a pipeline to generate counterfactuals and subsequently using it to estimate Shapley values, we obtain contrastive and interpretable explanations with strong axiomatic guarantees.

Despite their high accuracies, modern complex image classifiers cannot be trusted for sensitive tasks due to their unknown decision-making process and potential biases. Counterfactual explanations are very effective in providing transparency for these black-box algorithms. Nevertheless, generating counterfactuals that can have a consistent impact on classifier outputs and yet expose interpretable feature changes is a very challenging task. We introduce a novel method to generate causal and yet interpretable counterfactual explanations for image classifiers using pretrained generative models without any re-training or conditioning. The generative models in this technique are not bound to be trained on the same data as the target classifier. We use this framework to obtain contrastive and causal sufficiency and necessity scores as global explanations for black-box classifiers. On the task of face attribute classification, we show how different attributes influence the classifier output by providing both causal and contrastive feature attributions, and the corresponding counterfactual images.

The accelerated use of digital cameras prompts an increasing concern about privacy and security, particularly in applications such as action recognition. In this paper, we propose an optimizing framework to provide robust visual privacy protection along the human action recognition pipeline. Our framework parameterizes the camera lens to successfully degrade the quality of the videos to inhibit privacy attributes and protect against adversarial attacks while maintaining relevant features for activity recognition. We validate our approach with extensive simulations and hardware experiments., Comment: Oral paper presented at European Conference on Computer Vision (ECCV) 2022, in Tel Aviv, Israel

With the advent of sophisticated machine learning (ML) techniques and the promising results they yield, especially in medical applications, where they have been investigated for different tasks to enhance the decision-making process. Since visualization is such an effective tool for human comprehension, memorization, and judgment, we have presented a first-of-its-kind estimation approach we refer to as Visualized Learning for Machine Learning (VL4ML) that not only can serve to assist physicians and clinicians in making reasoned medical decisions, but it also allows to appreciate the uncertainty visualization, which could raise incertitude in making the appropriate classification or prediction. For the proof of concept, and to demonstrate the generalized nature of this visualized estimation approach, five different case studies are examined for different types of tasks including classification, regression, and longitudinal prediction. A survey analysis with more than 100 individuals is also conducted to assess users' feedback on this visualized estimation method. The experiments and the survey demonstrate the practical merits of the VL4ML that include: (1) appreciating visually clinical/medical estimations; (2) getting closer to the patients' preferences; (3) improving doctor-patient communication, and (4) visualizing the uncertainty introduced through the black box effect of the deployed ML algorithm. All the source codes are shared via a GitHub repository.

In this research paper, we study the capability of artificial neural network models to emulate storm surge based on the storm track/size/intensity history, leveraging a database of synthetic storm simulations. Traditionally, Computational Fluid Dynamics solvers are employed to numerically solve the storm surge governing equations that are Partial Differential Equations and are generally very costly to simulate. This study presents a neural network model that can predict storm surge, informed by a database of synthetic storm simulations. This model can serve as a fast and affordable emulator for the very expensive CFD solvers. The neural network model is trained with the storm track parameters used to drive the CFD solvers, and the output of the model is the time-series evolution of the predicted storm surge across multiple nodes within the spatial domain of interest. Once the model is trained, it can be deployed for further predictions based on new storm track inputs. The developed neural network model is a time-series model, a Long short-term memory, a variation of Recurrent Neural Network, which is enriched with Convolutional Neural Networks. The convolutional neural network is employed to capture the correlation of data spatially. Therefore, the temporal and spatial correlations of data are captured by the combination of the mentioned models, the ConvLSTM model. As the problem is a sequence to sequence time-series problem, an encoder-decoder ConvLSTM model is designed. Some other techniques in the process of model training are also employed to enrich the model performance. The results show the proposed convolutional recurrent neural network outperforms the Gaussian Process implementation for the examined synthetic storm database.

Accurate and automatic segmentation of intervertebral discs from medical images is a critical task for the assessment of spine-related diseases such as osteoporosis, vertebral fractures, and intervertebral disc herniation. To date, various approaches have been developed in the literature which routinely relies on detecting the discs as the primary step. A disadvantage of many cohort studies is that the localization algorithm also yields false-positive detections. In this study, we aim to alleviate this problem by proposing a novel U-Net-based structure to predict a set of candidates for intervertebral disc locations. In our design, we integrate the image shape information (image gradients) to encourage the model to learn rich and generic geometrical information. This additional signal guides the model to selectively emphasize the contextual representation and suppress the less discriminative features. On the post-processing side, to further decrease the false positive rate, we propose a permutation invariant 'look once' model, which accelerates the candidate recovery procedure. In comparison with previous studies, our proposed approach does not need to perform the selection in an iterative fashion. The proposed method was evaluated on the spine generic public multi-center dataset and demonstrated superior performance compared to previous work. We have provided the implementation code in https://github.com/rezazad68/intervertebral-lookonce

In this paper, we propose a framework where over-the-air computation (OAC) occurs in both uplink (UL) and downlink (DL), sequentially, in a multi-cell environment to address the latency and the scalability issues of federated edge learning (FEEL). To eliminate the channel state information (CSI) at the edge devices (EDs) and edge servers (ESs) and relax the time-synchronization requirement for the OAC, we use a non-coherent computation scheme, i.e., frequency-shift keying (FSK)-based majority vote (MV) (FSK-MV). With the proposed framework, multiple ESs function as the aggregation nodes in the UL and each ES determines the MVs independently. After the ESs broadcast the detected MVs, the EDs determine the sign of the gradient through another OAC in the DL. Hence, inter-cell interference is exploited for the OAC. In this study, we prove the convergence of the non-convex optimization problem for the FEEL with the proposed OAC framework. We also numerically evaluate the efficacy of the proposed method by comparing the test accuracy in both multi-cell and single-cell scenarios for both homogeneous and heterogeneous data distributions., Comment: 6 pages, accepted to International Conference on Communications (ICC) 2022

Joint forecasting of human trajectory and pose dynamics is a fundamental building block of various applications ranging from robotics and autonomous driving to surveillance systems. Predicting body dynamics requires capturing subtle information embedded in the humans' interactions with each other and with the objects present in the scene. In this paper, we propose a novel TRajectory and POse Dynamics (nicknamed TRiPOD) method based on graph attentional networks to model the human-human and human-object interactions both in the input space and the output space (decoded future output). The model is supplemented by a message passing interface over the graphs to fuse these different levels of interactions efficiently. Furthermore, to incorporate a real-world challenge, we propound to learn an indicator representing whether an estimated body joint is visible/invisible at each frame, e.g. due to occlusion or being outside the sensor field of view. Finally, we introduce a new benchmark for this joint task based on two challenging datasets (PoseTrack and 3DPW) and propose evaluation metrics to measure the effectiveness of predictions in the global space, even when there are invisible cases of joints. Our evaluation shows that TRiPOD outperforms all prior work and state-of-the-art specifically designed for each of the trajectory and pose forecasting tasks.

Imputation of missing data is a task that plays a vital role in a number of engineering and science applications. Often such missing data arise in experimental observations from limitations of sensors or post-processing transformation errors. Other times they arise from numerical and algorithmic constraints in computer simulations. One such instance and the application emphasis of this paper are numerical simulations of storm surge. The simulation data corresponds to time-series surge predictions over a number of save points within the geographic domain of interest, creating a spatio-temporal imputation problem where the surge points are heavily correlated spatially and temporally, and the missing values regions are structurally distributed at random. Very recently, machine learning techniques such as neural network methods have been developed and employed for missing data imputation tasks. Generative Adversarial Nets (GANs) and GAN-based techniques have particularly attracted attention as unsupervised machine learning methods. In this study, the Generative Adversarial Imputation Nets (GAIN) performance is improved by applying convolutional neural networks instead of fully connected layers to better capture the correlation of data and promote learning from the adjacent surge points. Another adjustment to the method needed specifically for the studied data is to consider the coordinates of the points as additional features to provide the model more information through the convolutional layers. We name our proposed method as Convolutional Generative Adversarial Imputation Nets (Conv-GAIN). The proposed method's performance by considering the improvements and adaptations required for the storm surge data is assessed and compared to the original GAIN and a few other techniques. The results show that Conv-GAIN has better performance than the alternative methods on the studied data.

The visual system processes a scene using a sequence of selective glimpses, each driven by spatial and object-based attention. These glimpses reflect what is relevant to the ongoing task and are selected through recurrent processing and recognition of the objects in the scene. In contrast, most models treat attention selection and recognition as separate stages in a feedforward process. Here we show that using capsule networks to create an object-centric hidden representation in an encoder-decoder model with iterative glimpse attention yields effective integration of attention and recognition. We evaluate our model on three multi-object recognition tasks; highly overlapping digits, digits among distracting clutter and house numbers, and show that it learns to effectively move its glimpse window, recognize and reconstruct the objects, all with only the classification as supervision. Our work takes a step toward a general architecture for how to integrate recurrent object-centric representation into the planning of attentional glimpses.