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102. Gewonnen - bis auf Weiteres.

Author

Shulsky, Abram N.

Subjects
LIBERALISM, ISLAM & politics, SECTARIAN conflict, PUBLIC opinion, RELIGION & politics
Abstract

Copyright of Internationale Politik is the property of Deutsche Gesellschaft fur Auswartige Politik e.V. (DGAP) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Author-supplied Abstracts.)

Published
2014

103. Liberalism's Beleaguered Victory: "The End of History?" at 25.

Author

Shulsky, Abram N.

Subjects
*DEMOCRACY, *LIBERALISM, *IDEOLOGY, *POSTCOMMUNISM, *POLITICAL attitudes
Abstract

The article discusses the victory of liberal democracy over its ideological competitors following the quick and peaceful collapse of communism. Topics covered include the 25th anniversary of Frank Fukuyama's "The End of History and the Last Man," the rise of Islamism and its geostrategic and political effects, and liberalism's counter-ideologies.

Published
2014

104. Silent Warfare

Author

Shulsky, Abram N., Schmitt, Gary James, Shulsky, Abram N., and Schmitt, Gary James

Subjects
Intelligence service, Intelligence service--United States
Abstract

A primer on intelligence, with an analysis that exposes the flaws in the conventional wisdom of today's intelligence community.

Published
2002

106. Abolishing the District of Columbia motorcycle squad

Author

Abram N. Shulsky

Subjects
Determinative, Public Administration, Sociology and Political Science, Process (engineering), Political science, Law, General Social Sciences, Resistance (psychoanalysis), sense organs, Management, Monitoring, Policy and Law, Development, Public administration, Metropolitan police
Abstract

The paper reviews the evidence concerning the abolition of the motorcycle squad of the Metropolitan Police Department of Washington, D.C. and, from it, attempts to draw inferences about the process of terminating governmental units and activities. It discusses the resistance which a small part of the police force was able to put up against the change, the compensatory and other mechanisms by which that resistance could be lessened and overcome, and the supportive, although hardly determinative, role of analysis in the process of change.

Published
1976
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107. Intelligence and Arms Control Policy

Author

Abram N. Shulsky

Subjects
International relations, Policy studies, Disarmament, Foreign policy, Political science, Political Science and International Relations, Operations management, Foreign policy analysis, Education policy, Public administration, Foreign relations, Arms control
Published
1989
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109. Why revive the Cold War?

Author

Feith, Douglas J. and Shulsky, Abram N.

Subjects
Arms control agreements -- Negotiation, mediation and arbitration, Arms control agreements -- Evaluation, Foreign policy -- Analysis, Military policy -- Analysis, Military policy -- Planning, Nuclear nonproliferation -- Negotiation, mediation and arbitration, Nuclear weapons -- Control, Nuclear weapons -- Forecasts and trends, Company business planning, Market trend/market analysis, News, opinion and commentary
Published
2009

111. In Vitro Aldose Reductase Inhibitory Activity of Substituted N-Benzenesulfonylglycine Derivatives

Author

DeRuiter, Jack, Brubaker, Abram N., Garner, Martha A., Barksdale, Jeffrey M., and Mayfield, Charles A.

Abstract

A number of N-benzenesulfonylglycines (4, alanines 5and 6), sarcosine (7), and prolines (8), which contain the minimum pharmacophore moieties necessary for aldose reductase inhibitory activity, were prepared and tested in the rat lens assay. In this assay, the benzenesulfonylglycines are considerably more potent than the corresponding alanine and sarcosine derivatives which, in turn, are more active than the proline analogues. Of the monosubstituted benzenesulfonylglycines, the 2-nitro (4a), and 4-amino (4b), derivatives were most active with 50% inhibitory concentration (IC50) values of 13 and 16 μM, respectively. The most potent derivatives evaluated were the β- and α-naphthylenesulfonylglycines (4iand 4j), with IC50values of 0.4 and 1.3 μM, respectively. The structure-activity data obtained from evaluation of the benzenesulfonylamino acids suggests that the aromatic ring and ring substituents, as well as the sulfonamide group and carboxylate moiety, all contribute to the inhibitory potency through direct interaction with complimentary binding sites present on aldose reductase.

Published
1987
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112. CORRESPONDENCE.

Author

Zakaria, Fareed, Monroe, Scott D., Young, Toby, Shulsky, Abram N., Wanniski, Judf, Kinsley, Michael, Roselin, Joel M., and Barber, Patricia

Subjects
LETTERS to the editor, FOREIGN correspondents, COMMUNICATION
Abstract

Presents letters to the editor about foreign correspondents and communication.

Published
1995

115. Greenland records of aerosol source and atmospheric lifetime changes from the Eemian to the Holocene

Author

Schüpbach, Simon, Fischer, Hubertus, Bigler, M., Erhardt, Tobias, Gfeller, Gideon, Leuenberger, Daiana, Mini, Olivia, Mulvaney, R., Abram, N. J., Fleet, L., Frey, M. M., Thomas, E., Svensson, A., Dahl-Jensen, D., Kettner, E., Kjaer, H., Seierstad, I., Steffensen, J. P., Rasmussen, S. O., Vallelonga, P., Winstrup, M., Wegner, A., Twarloh, B., Wolff, K., Schmidt, K., Goto-Azuma, K., Kuramoto, T., Hirabayashi, M., Uetake, J., Zheng, J., Bourgeois, J., Fisher, D., Zhiheng, D., Xiao, C., Legrand, M., Spolaor, A., Gabrieli, J., Barbante, C., Kang, J.-H., Hur, S. D., Hong, S. B., Hwang, H. J., Hong, S., Hansson, M., Iizuka, Y., Oyabu, I., Muscheler, R., Adolphi, Florian, Maselli, O., McConnell, J., and Wolff, E. W.

Subjects
13. Climate action, 530 Physics, complex mixtures
Abstract

The Northern Hemisphere experienced dramatic changes during the last glacial, featuring vast ice sheets and abrupt climate events, while high northern latitudes during the last interglacial (Eemian) were warmer than today. Here we use high-resolution aerosol records from the Greenland NEEM ice core to reconstruct the environmental alterations in aerosol source regions accompanying these changes. Separating source and transport effects, we find strongly reduced terrestrial biogenic emissions during glacial times reflecting net loss of vegetated area in North America. Rapid climate changes during the glacial have little effect on terrestrial biogenic aerosol emissions. A strong increase in terrestrial dust emissions during the coldest intervals indicates higher aridity and dust storm activity in East Asian deserts. Glacial sea salt aerosol emissions in the North Atlantic region increase only moderately (50%), likely due to sea ice expansion. Lower aerosol concentrations in Eemian ice compared to the Holocene are mainly due to shortened atmospheric residence time, while emissions changed little.

126. New Heaven, New Earth: Shakespeare's.

Author

SHULSKY, ABRAM N.

Subjects
*DRAMATIC criticism, *NONFICTION
Abstract

The article reviews the book "New Heaven, New Earth: Shakespeare's Antony and Cleopatra," by Jan H. Blits.

Published
2010

128. The Dangerous Illusion of 'Nuclear Zero.'.

Author

Feith, Douglas J. and Shulsky, Abram N.

Subjects
*NUCLEAR disarmament, *PEACE
Abstract

The authors question the rationale behind the Nuclear Posture Review (NPR) released by U.S. President Barack Obama's administration which requires world peace as precondition in which the U.S. and other countries can give up their nuclear weapons, due to failures of the United Nations (UN) Security Council to enforce treaties and the right of a nation to take action in the name of self-defense.

Published
2010

129. Automated Bayesian layer counting of ice cores

Author

Wheatley, Joseph, Blackwell, P., Wolff, E., Abram, N., and Mulvaney, R.

Subjects
510
Abstract

The polar ice sheets hold a continuous record of climatic and environmental information, in the composition and concentrations of various chemicals, particles and gasses, extending back over hundreds of thousands of years. In order to interpret these data we must first learn about the underlying relationship between depth and age. Ice cores are vertical samples of the ice sheets. Some signals measured from them have annual cycles which show as quasi-periodic seasonality; layer counting uses this periodicity to obtain a chronology for the core. This is currently achieved manually, which is time-consuming and open to inconsistency and human error. We present a method to standardise an ice core signal, isolating its seasonality, and to split it into sections with well-defined cycle counts and those with uncertain cycle counts. We show how the uncertain sections can be presented for manual assessment, and describe how the possible reconstructions can be identified and assigned probabilities based on their implied cycle lengths. We also develop a multivariate fully Bayesian approach, which models the signals as phase-shifted sine waves with continuously varying mean and amplitude. We use Markov chain Monte Carlo algorithms to enable inference about the age-depth relationship, and specifically the number of years covered by a particular section of ice core, including quantitative assessment of the uncertainty involved. We provide examples, applying our methods to several chemistry signals measured from ice cores from Greenland and Antarctica.

Published
2015

130. A global multiproxy database for temperature reconstructions of the Common Era

Author

Dmitry Divine, Dmitriy V. Ovchinnikov, Hugues Goosse, Marit-Solveig Seidenkrantz, Anne Hormes, Narayan Prasad Gaire, Joelle Gergis, Katrine Husum, David J. Nash, Konrad Gajewski, Jens Zinke, Vladimir Mikhalenko, Darrell S. Kaufman, Eugene R. Wahl, Martin Grosjean, Nancy A. N. Bertler, Pierre Francus, Anastasia Gornostaeva, Diana Vladimirova, Kaustubh Thirumalai, Lucien von Gunten, Kevin J. Anchukaitis, Michael Sigl, Ryu Uemura, Michael N. Evans, Hideaki Motoyama, Scott St. George, Marie-Alexandrine Sicre, Chris S. M. Turney, Johannes P. Werner, Robert Mulvaney, Jianghao Wang, Brian M. Chase, Mark A. J. Curran, Julien Emile-Geay, Takeshi Nakatsuka, David J. Sauchyn, Nerilie J. Abram, Bronwyn C. Dixon, Raphael Neukom, Cody C. Routson, Trevor J. Porter, Selvaraj Kandasamy, Mirko Severi, Massimo Frezzotti, Steven J. Phipps, Hans W. Linderholm, A. E. Viau, P. Graham Mortyn, Jessica E. Tierney, Eric J. Steig, Heidi A. Roop, K. Halimeda Kilbourne, Jason A. Addison, Jonathan J. Tyler, Mandy Freund, Daniel A. Dixon, Belen Martrat, Chenxi Xu, Krystyna M. Saunders, Min Te Chen, Xuemei Shao, Vasile Ersek, Philipp Munz, Hans Oerter, Masaki Sano, Zhixin Hao, Meloth Thamban, Alexey A. Ekaykin, Barbara Stenni, Kazuho Horiuchi, Ignacio A. Mundo, Zicheng Yu, Gregory T. Pederson, James W. C. White, Nalan Koc, Elisabeth Isaksson, Kathryn Allen, Rixt de Jong, Jeannine-Marie St. Jacques, Andrew Lorrey, Guillaume Leduc, Quansheng Ge, Kristine L. DeLong, Kenji Kawamura, Anais Orsi, Thomas Opel, Edward R. Cook, Kate E. Sinclair, Benjamin J. Henley, Nicholas P. McKay, Helen McGregor, Andrew D. Moy, Elizabeth R. Thomas, Jesper Björklund, Helena L. Filipsson, Udya Kuwar Thapa, Casey Saenger, Northern Arizona University [Flagstaff], Australian National University (ANU), United States Geological Survey [Reston] (USGS), University of Maryland [College Park], University of Maryland System, Spanish National Research Council [Madrid] (CSIC), School of Biological, Earth and Environmental Sciences [Sydney] (BEES), University of New South Wales [Sydney] (UNSW), Oeschger Centre for Climate Change Research (OCCR), University of Bern, Dipartimento di Scienze Geologiche [Trieste], Università degli studi di Trieste, University of Texas at Austin [Austin], Department of Earth and Space Sciences [Seattle], University of Washington [Seattle], Department of Earth Sciences [Oxford], University of Oxford [Oxford], Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Climate Change Institute (CCI), University of Maine, University of Northumbria at Newcastle [United Kingdom], Lund University [Lund], Centre Eau Terre Environnement - INRS (INRS-ETE), Institut National de la Recherche Scientifique [Québec] (INRS), Italian National agency for new technologies, Energy and sustainable economic development [Frascati] (ENEA), Nepal Academy of Science and Technology, Université Catholique de Louvain (UCL), Quaternary Geology, The University Centre in Svalbard (UNIS), Norwegian Polar Institute, Climate and Environmental Physics [Bern] (CEP), Physikalisches Institut [Bern], Universität Bern [Bern]-Universität Bern [Bern], University of Maryland Center for Environmental Science, Horn Point Laboratory, Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Universitat Autònoma de Barcelona [Barcelona] (UAB), National Institute of Polar Research [Tokyo] (NiPR), British Antarctic Survey (BAS), Natural Environment Research Council (NERC), School of Environment and Technology, University of Brighton, Abteilung Klinische Sozialmedizin, Berufs- und Umweltdermatologie, Universität Heidelberg [Heidelberg], Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), The University of Tokyo, Laboratoire de géographie physique : Environnements Quaternaires et Actuels (LGP), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Université Panthéon-Sorbonne (UP1), Aarhus University [Aarhus], Department of Chemistry, University of Florence (UNIFI), Biogéochimie-Traceurs-Paléoclimat (BTP), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN), Paul Scherrer Institute (PSI), University of the Ryukyus [Okinawa], Australian Institute of Marine Science (AIMS), PAGES 2k, Università degli studi di Trieste = University of Trieste, University of Oxford, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Climate Change Institute [Orono] (CCI), Centre Eau Terre Environnement [Québec] (INRS - ETE), Université Catholique de Louvain = Catholic University of Louvain (UCL), Universität Bern [Bern] (UNIBE)-Universität Bern [Bern] (UNIBE), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Universitat Autònoma de Barcelona (UAB), Universität Heidelberg [Heidelberg] = Heidelberg University, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Glaces et Continents, Climats et Isotopes Stables (GLACCIOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), The University of Tokyo (UTokyo), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Firenze = University of Florence (UniFI), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Emile-Geay, J., Mckay, N. P., Kaufman, D. S., Von Gunten, L., Wang, Junrong, Anchukaitis, K. J., Abram, N. J., Addison, J. A., Curran, M. A. J., Evans, M. N., Henley, B. J., Hao, Z., Martrat, B., Mcgregor, H. V., Neukom, R., Pederson, G. T., Stenni, B., Thirumalai, K., Werner, J. P., Xu, C., Divine, D. V., Dixon, B. C., Gergis, J., Mundo, I. A., Nakatsuka, T., Phipps, S. J., Routson, C. C., Steig, E. J., Tierney, J. E., Tyler, J. J., Allen, K. J., Bertler, N. A. N., Bjorklund, J., Chase, B. M., Chen, M. -T., Cook, E., De Jong, R., Delong, K. L., Dixon, D. A., Ekaykin, A. A., Ersek, V., Filipsson, H. L., Francus, P., Freund, M. B., Frezzotti, M., Gaire, N. P., Gajewski, K., Ge, Q., Goosse, H., Gornostaeva, A., Grosjean, M., Horiuchi, K., Hormes, A., Husum, K., Isaksson, E., Kandasamy, S., Kawamura, K., Kilbourne, K. H., Koc, N., Leduc, G., Linderholm, H. W., Lorrey, A. M., Mikhalenko, V., Mortyn, P. G., Motoyama, H., Moy, A. D., Mulvaney, R., Munz, P. M., Nash, D. J., Oerter, H., Opel, T., Orsi, A. J., Ovchinnikov, D. V., Porter, T. J., Roop, H. A., Saenger, C., Sano, M., Sauchyn, D., Saunders, K. M., Seidenkrantz, M. -S., Severi, M., Shao, X., Sicre, M. -A., Sigl, M., Sinclair, K., St George, S., St Jacques, J. -M., Thamban, M., Thapa, U. K., Thomas, E. R., Turney, C., Uemura, R., Viau, A. E., Vladimirova, D. O., Wahl, E. R., White, J. W. C., Yu, Z., Zinke, J., École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, and UCL - SST/ELI/ELIC - Earth & Climate

Subjects
Data Descriptor, 010504 meteorology & atmospheric sciences, VDP::Mathematics and natural science: 400::Mathematics: 410::Statistics: 412, VDP::Matematikk og Naturvitenskap: 400::Matematikk: 410::Statistikk: 412, F800, computer.software_genre, Palaeoclimate, 01 natural sciences, Proxy (climate), CECI [CISM], calcification, data integration objective, Climate change, trace metal analysis, 910 Geography & travel, geography.geographical_feature_category, Database, G500, data acquisition system, temperature of environmental material, Computer Science Applications, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, Temperature reconstruction, Statistics, Probability and Uncertainty, Tree ring, Geology, wood, Information Systems, Statistics and Probability, glacial ice, radiance, 010506 paleontology, observation design, Library and Information Sciences, archaeal metabolite, Education, time series design, stable isotope analysis, Dendrochronology, 550 Earth sciences & geology, 0105 earth and related environmental sciences, geography, Global temperature, Glacier, 15. Life on land, Sea surface temperature, sediment, 13. Climate action, North Atlantic oscillation, Oceanic basin, computer
Abstract

Reproducible climate reconstructions of the Common Era (1 CE to present) are key to placing industrial-era warming into the context of natural climatic variability. Here we present a community-sourced database of temperature-sensitive proxy records from the PAGES2k initiative. The database gathers 692 records from 648 locations, including all continental regions and major ocean basins. The records are from trees, ice, sediment, corals, speleothems, documentary evidence, and other archives. They range in length from 50 to 2000 years, with a median of 547 years, while temporal resolution ranges from biweekly to centennial. Nearly half of the proxy time series are significantly correlated with HadCRUT4.2 surface temperature over the period 1850-2014. Global temperature composites show a remarkable degree of coherence between high- and low-resolution archives, with broadly similar patterns across archive types, terrestrial versus marine locations, and screening criteria. The database is suited to investigations of global and regional temperature variability over the Common Era, and is shared in the Linked Paleo Data (LiPD) format, including serializations in Matlab, R and Python., PAGES, a core project of Future Earth, is supported by the U.S. and Swiss National Science Foundations. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Some of this work was conducted as part of the North America 2k Working Group supported by the John Wesley Powell Center for Analysis and Synthesis, funded by the U.S. Geological Survey. B. Bauer, W. Gross, and E. Gille (NOAA National Centers for Environmental Information) are gratefully acknowledged for helping assemble the data citations and creating the NCEI versions of the PAGES 2k data records. We thank all the investigators whose commitment to data sharing enables the open science ethos embodied by this project.

Published
2017
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131. Managing acute COVID-19 in immunocompromised pediatric patients.

Author

Mercolini F, Abram N, and Cesaro S

Subjects
Adult, Humans, Child, SARS-CoV-2, Antibodies, Monoclonal, Immunologic Factors, Anti-Inflammatory Agents, Antiviral Agents, COVID-19
Abstract

Introduction: SARS-CoV-2 infection is a potentially life-threatening infection in immunocompromised pediatric patients, and its management has rapidly evolved during the pandemic. To control SARS-CoV-2 infection over time, the scenario changed for the better with the introduction of specific treatments such as antiviral drugs, vaccines, and monoclonal antibodies, together with drugs blocking the inflammatory cytokine cascade and improvements in supportive care., Areas Covered: This paper discusses the therapeutic strategies to apply for patients affected by COVID-19 in the pediatric population, with a focus on the immunocompromised patients., Expert Opinion: Treatment in pediatric patients retraces the therapies investigated and approved in adults and must be calibrated on the basis of the severity of the infection (anti-spike monoclonal antibody, antivirals, anti-inflammatory drugs, and immunomodulators). Transmission prevention policies and vaccination reduce the risk of infection, while early intervention in the immunocompromised patients at high-risk of progression to severe-critical COVID-19 may reduce the period of viral shedding and the need for hospitalization, intensive care admission, and death. In hemato-oncological patients, the delayed treatment of SARS-CoV-2 infection or COVID-19 disease represents a frequent complication and its impact on the patient outcome remains a matter of research for the next few years.

Published
2024
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132. Antibiotic prophylaxis and management of infections in pediatric hematopoietic stem cell transplantation: a survey from the Stem Cell Transplant and the Infectious Disease Working Groups of the AIEOP network.

Author

Zama D, Masetti R, Baccelli F, Leardini D, Muratore E, Abram N, Vendemini F, Biffi A, Perruccio K, D'Amico MR, Faraci M, Tintori V, Spirito A, Lo Nigro L, Locatelli F, Luksch R, Saglio F, Santoro N, Soncini E, Zecca M, Ziino O, Prete A, Pagliara D, and Cesaro S

Subjects
Child, Humans, Antibiotic Prophylaxis, Stem Cell Transplantation, Hematopoietic Stem Cell Transplantation, Communicable Diseases
Published
2022
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133. Effectiveness of Quinolone Prophylaxis in Pediatric Acute Leukemia and Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-analysis.

Author

Leardini D, Muratore E, Abram N, Baccelli F, Belotti T, Prete A, Gori D, and Masetti R

Abstract

The effectiveness of quinolone prophylaxis in high-risk hematological pediatric patients is controversial. A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, including studies that involved children and young adults undergoing chemotherapy for acute leukemia or hematopoietic stem cell transplantation (HSCT) who received quinolone prophylaxis compared with no prophylaxis. A meta-analysis was performed on bloodstream infections and neutropenic fever. Data regarding the impact of prophylaxis on overall survival, antibiotic exposure, antibiotic-related adverse effects, antibiotic resistance, Clostridium difficile infections, fungal infections, length of hospitalization, and costs were reviewed in the descriptive analysis. Sixteen studies were included in the qualitative analysis, and 10 of them met the criteria for quantitative analysis. Quinolone prophylaxis was effective in reducing the rate of bloodstream infections and neutropenic fever in pediatric acute leukemia compared with no prophylaxis, but it had no significant effect in HSCT recipients. Prophylaxis was associated with a higher rate of bacterial resistance to fluoroquinolones and higher antibiotic exposure., (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)

Published
2022
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134. Global Demand for Natural Resources Eliminated More Than 100,000 Bornean Orangutans.

Author

Voigt M, Wich SA, Ancrenaz M, Meijaard E, Abram N, Banes GL, Campbell-Smith G, d'Arcy LJ, Delgado RA, Erman A, Gaveau D, Goossens B, Heinicke S, Houghton M, Husson SJ, Leiman A, Sanchez KL, Makinuddin N, Marshall AJ, Meididit A, Miettinen J, Mundry R, Musnanda, Nardiyono, Nurcahyo A, Odom K, Panda A, Prasetyo D, Priadjati A, Purnomo, Rafiastanto A, Russon AE, Santika T, Sihite J, Spehar S, Struebig M, Sulbaran-Romero E, Tjiu A, Wells J, Wilson KA, and Kühl HS

Subjects
Animals, Borneo, Indonesia, Malaysia, Natural Resources supply & distribution, Population Dynamics, Conservation of Natural Resources, Endangered Species trends, Pongo pygmaeus physiology
Abstract

Unsustainable exploitation of natural resources is increasingly affecting the highly biodiverse tropics [1, 2]. Although rapid developments in remote sensing technology have permitted more precise estimates of land-cover change over large spatial scales [3-5], our knowledge about the effects of these changes on wildlife is much more sparse [6, 7]. Here we use field survey data, predictive density distribution modeling, and remote sensing to investigate the impact of resource use and land-use changes on the density distribution of Bornean orangutans (Pongo pygmaeus). Our models indicate that between 1999 and 2015, half of the orangutan population was affected by logging, deforestation, or industrialized plantations. Although land clearance caused the most dramatic rates of decline, it accounted for only a small proportion of the total loss. A much larger number of orangutans were lost in selectively logged and primary forests, where rates of decline were less precipitous, but where far more orangutans are found. This suggests that further drivers, independent of land-use change, contribute to orangutan loss. This finding is consistent with studies reporting hunting as a major cause in orangutan decline [8-10]. Our predictions of orangutan abundance loss across Borneo suggest that the population decreased by more than 100,000 individuals, corroborating recent estimates of decline [11]. Practical solutions to prevent future orangutan decline can only be realized by addressing its complex causes in a holistic manner across political and societal sectors, such as in land-use planning, resource exploitation, infrastructure development, and education, and by increasing long-term sustainability [12]. VIDEO ABSTRACT., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Published
2018
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135. First integrative trend analysis for a great ape species in Borneo.

Author

Santika T, Ancrenaz M, Wilson KA, Spehar S, Abram N, Banes GL, Campbell-Smith G, Curran L, d'Arcy L, Delgado RA, Erman A, Goossens B, Hartanto H, Houghton M, Husson SJ, Kühl HS, Lackman I, Leiman A, Llano Sanchez K, Makinuddin N, Marshall AJ, Meididit A, Mengersen K, Musnanda, Nardiyono, Nurcahyo A, Odom K, Panda A, Prasetyo D, Purnomo, Rafiastanto A, Raharjo S, Ratnasari D, Russon AE, Santana AH, Santoso E, Sapari I, Sihite J, Suyoko A, Tjiu A, Utami-Atmoko SS, van Schaik CP, Voigt M, Wells J, Wich SA, Willems EP, and Meijaard E

Subjects
Animals, Borneo, Models, Statistical, Survival Analysis, Endangered Species, Pongo pygmaeus growth & development, Population Dynamics trends
Abstract

For many threatened species the rate and drivers of population decline are difficult to assess accurately: species' surveys are typically restricted to small geographic areas, are conducted over short time periods, and employ a wide range of survey protocols. We addressed methodological challenges for assessing change in the abundance of an endangered species. We applied novel methods for integrating field and interview survey data for the critically endangered Bornean orangutan (Pongo pygmaeus), allowing a deeper understanding of the species' persistence through time. Our analysis revealed that Bornean orangutan populations have declined at a rate of 25% over the last 10 years. Survival rates of the species are lowest in areas with intermediate rainfall, where complex interrelations between soil fertility, agricultural productivity, and human settlement patterns influence persistence. These areas also have highest threats from human-wildlife conflict. Survival rates are further positively associated with forest extent, but are lower in areas where surrounding forest has been recently converted to industrial agriculture. Our study highlights the urgency of determining specific management interventions needed in different locations to counter the trend of decline and its associated drivers.

Published
2017
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136. Impact of a Neonatal-Bereavement-Support DVD on Parental Grief: A Randomized Controlled Trial.

Author

Rosenbaum JL, Smith JR, Yan Y, Abram N, and Jeffe DB

Subjects
Adaptation, Psychological, Adult, Female, Grief, Humans, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Male, Patient Care Team, Treatment Outcome, Bereavement, CD-ROM, Infant Death, Parents psychology, Perinatal Care methods, Social Support
Abstract

This study tested the effect of a neonatal-bereavement-support DVD on parental grief after their baby's death in a Neonatal Intensive Care Unit compared with standard bereavement care (controls). Following a neonatal death, the authors measured grief change from a 3- to 12-month follow-up using a mixed-effects model. Intent-to-treat analysis was not significant, but only 18 parents selectively watched the DVD. Thus, we subsequently compared DVD viewers with DVD nonviewers and controls. DVD viewers reported higher grief at 3-month interviews compared with DVD nonviewers and controls. Higher grief at 3 months was negatively correlated with social support and spiritual/religious beliefs. These findings have implications for neonatal-bereavement care.

Published
2015
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137. Understanding the impacts of land-use policies on a threatened species: is there a future for the Bornean orang-utan?

Author

Wich SA, Gaveau D, Abram N, Ancrenaz M, Baccini A, Brend S, Curran L, Delgado RA, Erman A, Fredriksson GM, Goossens B, Husson SJ, Lackman I, Marshall AJ, Naomi A, Molidena E, Nardiyono, Nurcahyo A, Odom K, Panda A, Purnomo, Rafiastanto A, Ratnasari D, Santana AH, Sapari I, van Schaik CP, Sihite J, Spehar S, Santoso E, Suyoko A, Tiju A, Usher G, Atmoko SS, Willems EP, and Meijaard E

Subjects
Animals, Borneo, Ecosystem, Environment, Trees, Endangered Species trends, Phylogeography, Pongo pygmaeus
Abstract

The geographic distribution of Bornean orang-utans and its overlap with existing land-use categories (protected areas, logging and plantation concessions) is a necessary foundation to prioritize conservation planning. Based on an extensive orang-utan survey dataset and a number of environmental variables, we modelled an orang-utan distribution map. The modelled orang-utan distribution map covers 155,106 km(2) (21% of Borneo's landmass) and reveals four distinct distribution areas. The most important environmental predictors are annual rainfall and land cover. The overlap of the orang-utan distribution with land-use categories reveals that only 22% of the distribution lies in protected areas, but that 29% lies in natural forest concessions. A further 19% and 6% occurs in largely undeveloped oil palm and tree plantation concessions, respectively. The remaining 24% of the orang-utan distribution range occurs outside of protected areas and outside of concessions. An estimated 49% of the orang-utan distribution will be lost if all forest outside of protected areas and logging concessions is lost. To avoid this potential decline plantation development in orang-utan habitats must be halted because it infringes on national laws of species protection. Further growth of the plantation sector should be achieved through increasing yields in existing plantations and expansion of new plantations into areas that have already been deforested. To reach this goal a large scale island-wide land-use masterplan is needed that clarifies which possible land uses and managements are allowed in the landscape and provides new standardized strategic conservation policies. Such a process should make much better use of non-market values of ecosystem services of forests such as water provision, flood control, carbon sequestration, and sources of livelihood for rural communities. Presently land use planning is more driven by vested interests and direct and immediate economic gains, rather than by approaches that take into consideration social equity and environmental sustainability.

Published
2012
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139. Effects of chiropractic treatment on blood pressure and anxiety: a randomized, controlled trial.

Author

Yates RG, Lamping DL, Abram NL, and Wright C

Subjects
Adult, Clinical Trials as Topic, Humans, Middle Aged, Random Allocation, Anxiety, Blood Pressure, Chiropractic
Abstract

This study examined the effects of chiropractic adjustments of the thoracic spine (T1-T5) on blood pressure and state anxiety in 21 patients with elevated blood pressure. Subjects were randomly assigned to one of three treatment conditions: active treatment, placebo treatment, or no treatment control. The adjustments were performed by a mechanical chiropractic adjusting device. Dependent measures obtained pre- and post-treatment included systolic and diastolic blood pressure, and state anxiety. Results indicated that systolic and diastolic blood pressure decreased significantly in the active treatment condition, whereas no significant changes occurred in the placebo and control conditions. State anxiety significantly decreased in the active and control conditions. Results provide support for the hypothesis that blood pressure is reduced following chiropractic treatment. Further study is needed to examine the long-term effects of chiropractic treatment on blood pressure.

Published
1988

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