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622 results on '"Abdel‐Naim, Ashraf B."'

102. Chitosan-Based Microparticles Enhance Ellagic Acid’s Colon Targeting and Proapoptotic Activity

Author

Alhakamy, Nabil A., primary, Ahmed, Osama A. A., additional, Kurakula, Mallesh, additional, Caruso, Giuseppe, additional, Caraci, Filippo, additional, Asfour, Hani Z., additional, Alfarsi, Anas, additional, Eid, Basma G., additional, Mohamed, Amir I., additional, K. Alruwaili, Nabil, additional, Abdulaal, Wesam H., additional, Fahmy, Usama A., additional, Alhadrami, Hani A., additional, Eldakhakhny, Basmah M., additional, and Abdel-Naim, Ashraf B., additional

Published
2020
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104. Piceatannol-Loaded Emulsomes Exhibit Enhanced Cytostatic and Apoptotic Activities in Colon Cancer Cells

Author

Alhakamy, Nabil A., primary, Badr-Eldin, Shaimaa M., additional, Ahmed, Osama A. A., additional, Asfour, Hani Z., additional, Aldawsari, Hibah M., additional, Algandaby, Mardi M., additional, Eid, Basma G., additional, Abdel-Naim, Ashraf B., additional, Awan, Zuhier A., additional, Alghaith, Adel F., additional, Alaofi, Ahmed L., additional, Mohamed, Amir I., additional, Okbazghi, Solomon Z., additional, Al-Rabia, Mohammed W., additional, and Fahmy, Usama A., additional

Published
2020
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106. Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity

Author

Alhakamy, Nabil A., primary, Fahmy, Usama A., additional, Ahmed, Osama A. A., additional, Caruso, Giuseppe, additional, Caraci, Filippo, additional, Asfour, Hani Z., additional, Bakhrebah, Muhammed A., additional, N. Alomary, Mohammad, additional, Abdulaal, Wesam H., additional, Okbazghi, Solomon Z., additional, Abdel-Naim, Ashraf B., additional, Eid, Basma G., additional, Aldawsari, Hibah M., additional, Kurakula, Mallesh, additional, and Mohamed, Amir I., additional

Published
2020
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107. Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

Author

Alhakamy, Nabil A., primary, A. Fahmy, Usama, additional, Badr-Eldin, Shaimaa M., additional, Ahmed, Osama A. A., additional, Asfour, Hani Z., additional, Aldawsari, Hibah M., additional, Algandaby, Mardi M., additional, Eid, Basma G., additional, Abdel-Naim, Ashraf B., additional, Awan, Zuhier A., additional, K. Alruwaili, Nabil, additional, and Mohamed, Amir I., additional

Published
2020
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124. Syzygium aqueum: A Polyphenol- Rich Leaf Extract Exhibits Antioxidant, Hepatoprotective, Pain-Killing and Anti-inflammatory Activities in Animal Models

Author

Sobeh, Mansour, primary, Mahmoud, Mona F., additional, Petruk, Ganna, additional, Rezq, Samar, additional, Ashour, Mohamed L., additional, Youssef, Fadia S., additional, El-Shazly, Assem M., additional, Monti, Daria M., additional, Abdel-Naim, Ashraf B., additional, and Wink, Michael, additional

Published
2018
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126. Correction: Nasrullah et al. Omeprazole Prevents Colistin-Induced Nephrotoxicity in Rats: Emphasis on Oxidative Stress, Inflammation, Apoptosis and Colistin Accumulation in Kidneys. Pharmaceuticals 2022, 15 , 782.

Author

Nasrullah, Mohammed Z., Eljaaly, Khalid, Neamatallah, Thikryat, Fahmy, Usama A., Alamoudi, Abdulmohsin J., Bakhsh, Hussain T., and Abdel-Naim, Ashraf B.

Subjects
OMEPRAZOLE, NEPHROTOXICOLOGY, COLISTIN, APOPTOSIS, RATS, OXIDATIVE stress
Abstract

Error in FigureIn the original publication [[1]], there was a mistake in Figure 2. There was an error in the sub-image of the first row, last column. The corrected Figure 2 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.GraphBy Mohammed Z. Nasrullah; Khalid Eljaaly; Thikryat Neamatallah; Usama A. Fahmy; Abdulmohsin J. Alamoudi; Hussain T. Bakhsh and Ashraf B. Abdel-NaimReported by Author; Author; Author; Author; Author; Author; Author [Extracted from the article]

Published
2024
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134. Development, optimization, and evaluation of Empagliflozin nanoemulsion for the management of neuroinflammation associated Alzheimer's disease

Author

Alhakamy, Nabil A., Aljehani, Essam Ali, Abdel-Naim, Ashraf B., Shaik, Rasheed A., Iqubal, Mohammad Kashif, Asfour, Hani Z., Bazuhair, Mohammed A., and Md, Shadab

Abstract

Alzheimer's disease (AD) is one of the most pervasive and progressive neurodegenerative disorders. Recently, empagliflozin (EMPA) has been reported as a potent anti-inflammatory and antioxidant in neuroinflammatory disorders apart from antidiabetic activity. To use EMPA for neuroinflammation-associated AD, EMPA must first cross blood–brain barrier (BBB). Hence, an optimized EMPA-nanoemulsion (EMPA-NE) was formulated by applying Box–Behnken experimental design (BBD) approach. The focus of this investigation was to develop, optimize, and evaluate EMPA-NE for the management of neuroinflammation-associated AD. The experimental EMPA-NE had a particle size of 136.1 nm, 0.281 PDI, and zeta potential of −23.9 mV. The lower viscosity of optimized NE showed its usefulness for oral administration. The dispersibility and thermodynamic analysis showed NE stability under different environmental conditions. The release study demonstrated steady, regulated drug release after initial fast drug release from NE. In addition, a stability study of optimized EMPA-NE showed no notable changes in drug content, particle sizes, PDI, and zeta potential. Histopathological estimation showed cells with normal characteristics in EMPA-NE-treated group versus the EMPA-treated group. Antioxidant studies demonstrated a significant increment of SOD (p < 0.001), and CAT (p < 0.001) levels, and a reduction in MDA content (p < 0.001) and effective reversal of high AchE levels (p < 0.001) was also found in EMPA-NE-treated group as compared to LPS treated group. Treatment with EMPA-NE caused a marked reduction in Iba1 molecule and GFAP expression levels, thus demonstrating the anti-inflammatory and neuroprotective potency of EMPA-NE. Therefore, this study reveals promising antioxidant and anti-inflammatory properties of EMPA-NE, which could provide an effective approach to the management of neuroinflammation-associated AD.

Published
2024
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135. A new triterpene and protective effect of Periploca somaliensis Browicz fruits against CCl4-induced injury on human hepatoma cell line (Huh7)

Author

Azza R. Abdel-Monem, Kandil, Zeinab A., Abdel-Naim, Ashraf B., and Abdel-Sattar, Essam

Abstract

The potential hepatoprotective effect of the methanolic extract of Periploca somaliensis Browicz fruits, its different fractions (n-hexane, chloroform and n-butanol) and the major isolated compound ursolic acid was evaluated using the human hepatoma cell line (Huh7) based on the changes in the activity of aspartate aminotransferase, alanine transaminase, glutathione and superoxide dismutase. Each sample was tested at three different concentrations (1000, 100 and 10 μg/mL). All tested samples exhibited a potent concentration-independent cytoprotective effect relative to silymarin as a reference standard. Chromatographic fractionation of the chloroform-soluble fraction of the methanol extract of P. somaliensis Browicz fruits afforded two known triterpenes, namely ursolic acid, and 11α,12α-epoxy-3β-hydroxy-olean-13β,28-olide, and a newly discovered one, namely 3β-hydroxy-urs-11-en-13β,28-olide. The structures of the isolated compounds were elucidated by the analysis of 1D and 2D NMR spectral data.

Published
2015
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142. Cucurbitacin‐B attenuates CCl4‐induced hepatic fibrosis in mice through inhibition of STAT‐3.

Author

Sallam, Alaliaa M., Esmat, Ahmed, and Abdel‐Naim, Ashraf B.

Subjects
FIBROSIS, CUCURBITACINS, ADAPTOR proteins, TRANSCRIPTION factors, HEPATIC fibrosis, THERAPEUTICS, IMMUNOLOGY
Abstract

Liver fibrosis is a major health concern worldwide. Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) have been reported to attenuate experimental liver fibrosis. Therefore, the aim of this study was to investigate the potential ameliorative effect of cucurbitacin‐B (Cucu‐B) against CCl4‐induced liver fibrosis in mice. Treatment with Cucu‐B (5 mg/kg) preserved hepatocellular membrane integrity and amended the metabolic function as indicated by preventing the rise of serum liver function markers. This was confirmed histologically. CCl4‐induced oxidative stress was improved by Cucu‐B treatment (1 and 5 mg/kg). Furthermore, Cucu‐B treatment ameliorated the fibrotic state as evidenced by inhibiting the rise of hydroxyproline liver content and mitigating the overexpressions of collagen‐1α, α‐smooth muscle actin (α‐SMA) and transforming growth factor beta (TGF‐β) as well as the downexpression of matrix metalloproteinase‐2 (MMP‐2) mRNA. Importantly, STAT3 activity was inhibited by Cucu‐B as confirmed by decreased phosphorylation of STAT3 without changing total STAT3 expression. This was substantiated by the reduced Bcl‐2 together with increased Bax mRNA expressions with subsequent elevation of Bax/Bcl‐2 ratio. In conclusion, Cucu‐B hampers CCl4‐induced liver fibrosis in mice. This can be attributed—at least partly—to inhibition of oxidative stress, inflammation and STAT3 signalling. [ABSTRACT FROM AUTHOR]

Published
2018
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143. Antiproliferative effects of triterpenoidal derivatives, obtained from the marine sponge Siphonochalina sp., on human hepatic and colorectal cancer cells

Author

Abdel-Lateff, Ahmed, primary, Al-Abd, Ahmed M., additional, Alahdal, Abdulrahman M., additional, Alarif, Walied M., additional, Ayyad, Seif-Eldin N., additional, Al-Lihaibi, Sultan S., additional, Hegazy, Mohamed E., additional, Al Mohammadi, Ameen, additional, Abdelghany, Tamer M., additional, Abdel-Naim, Ashraf B., additional, Moustafa, Mohamed A.A., additional, Banjer, Zainy M., additional, and Azhar, Ahmad S., additional

Published
2016
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147. Corrigendum: the anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats

Author

Mahdy, Heba M., Mohamed, Mohamed R., Emam, Manal A., Karim, Amr M., Abdel-Naim, Ashraf B., and Khalifa, Amani E.

Abstract

Ref.: Can. J. Physiol. Pharmacol. 92(3): 252-258 (2014). The in the original article, the name of the fifth co-author appears as Ashraf Abdel-Naim, but should have been printed as Ashraf [...]

Published
2014
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148. Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies – A review.

Author

Al-Abd, Ahmed M., Alamoudi, Abdulmohsin J., Abdel-Naim, Ashraf B., Neamatallah, Thikryat A., and Ashour, Osama M.

Abstract

Recent strategies for the treatment of cancer, other than just tumor cell killing have been under intensive development, such as anti-angiogenic therapeutic approach. Angiogenesis inhibition is an important strategy for the treatment of solid tumors, which basically depends on cutting off the blood supply to tumor micro-regions, resulting in pan-hypoxia and pan-necrosis within solid tumor tissues. The differential activation of angiogenesis between normal and tumor tissues makes this process an attractive strategic target for anti-tumor drug discovery. The principles of anti-angiogenic treatment for solid tumors were originally proposed in 1972, and ever since, it has become a putative target for therapies directed against solid tumors. In the early twenty first century, the FDA approved anti-angiogenic drugs, such as bevacizumab and sorafenib for the treatment of several solid tumors. Over the past two decades, researches have continued to improve the performance of anti-angiogenic drugs, describe their drug interaction potential, and uncover possible reasons for potential treatment resistance. Herein, we present an update to the pre-clinical and clinical situations of anti-angiogenic agents and discuss the most recent trends in this field. [ABSTRACT FROM AUTHOR]

Published
2017
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149. Phenolics Isolated from Aframomum meleguta Enhance Proliferation and Ossification Markers in Bone Cells.

Author

Abdel-Naim, Ashraf B., Alghamdi, Abdullah A., Algandaby, Mardi M., Al-Abbasi, Fahad A., Al-Abd, Ahmed M., Abdallah, Hossam M., El-Halawany, Ali M., and Masao Hattori

Subjects
*OSTEOPOROSIS, *GRAINS of paradise, *BONE cells, *PHENOLS, *NUCLEAR magnetic resonance
Abstract

Osteoporosis is a serious health problem characterized by decreased bone mineral density and deterioration of bone microarchitecture. Current antiosteoporotic agents exhibit a wide range of adverse effects; meanwhile, phytochemicals are effective and safer alternatives. In the current work, nine compounds belonging to hydroxyphenylalkane and diarylheptanoid groups were isolated from Aframomum meleguea seeds and identified as 6-gingerol (1), 6-paradol (2), 8-dehydrogingerdione (3), 8-gingerol (4), dihydro-6-paradol (5), dihydrogingerenone A (6), dihydrogingerenone C (7), 1,7-bis(3,4-dihydroxy-5-methoxyphenyl)heptane-3,5-diyl diacetate (8), and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(3,4-dihydroxyphenyl)heptane-3,5-diyl diacetate (9). The structures of isolated compounds were established by NMR and mass spectral data, in addition to referring to literature data. Exposure of MCF-7, MG-63, and SAOS-2 cells to subcytotoxic concentrations of the compounds under investigation resulted in accelerated proliferation. Among them, paradol was selected for further detailed biochemical analysis in SAOS-2 cells. DNA flowcytometric analysis of cell cycle distribution revealed that paradol did not induce any significant change in the proliferation index of SAOS-2 cells. Assessment of osteogenic gene expression revealed that paradol enhanced the expression of osteocyte and osteoblast-related genes and inhibited osteoclast and RUNX suppressor genes. Biochemically, paradol enhanced alkaline phosphatase activity and vitamin D content and decreased the osteoporotic marker acid phosphatase. In conclusion, paradol, which is a major constituents of A. melegueta seeds, exhibited potent proliferative and ossification characteristics in bone cells. [ABSTRACT FROM AUTHOR]

Published
2017
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150. Antiproliferative effects of selected marine organisms collected from Red Sea.

Author

Abdel-lateff, Ahmed, Alarif, Walied M., Al-Lihaibi, Sultan S., and Abdel-Naim, Ashraf B.

Abstract

Ten selected marine organisms representing different classes of marine fauna and flora were collected from Saudi Arabia territorial water. They were Antipathes dichotoma, Rumphella sp., Dictoyota dichotoma, Hyrtios erectus, Petrosia sp., Heteroxenia fuscescens, Rumphella aggregata, Sinularia polydactyla, Sarcophyton glaucum, Sarcophyton trocheliophorum. Samples were lyophilized and extracted. Their cytotoxic activity was assessed by determining their IC50's against HepG2, A549 and PC-3 cancer cell lines. The extracts showed variable activities against A549 with IC50 in the range 388.3-0.1µg/mL; HepG2 with IC50 in range 382.5-0.1µg/mL and PC-3 with IC50 in the range 428.6-0.1µg/mL. Dictoyota dichotoma, Hyrtios erectus, Rumphella aggregata and Sarcophyton glaucum exhibited the highest antiproliferative activity. Therefore, their impact on cell cycle was examined by flow cytometry technique. It was concluded that they cause G0/G1, S-phase and G2/M cell cycle arrest. [ABSTRACT FROM AUTHOR]

Published
2017

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