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Abstract Background Data on the use of lipid emulsions containing fish-oil (FO) derived n-3 polyunsaturated fatty acids (n-3 PUFAs) in addition to medium- and long-chain triglycerides (MCT/LCT) for long-term home parenteral nutrition (HPN) are limited. This study aimed to compare HPN regimens containing either MCT/LCT/FO-derived n-3 PUFAs (test group) or MCT/LCT (control group) with respect to efficacy and safety during 8 weeks of HPN using a non-inferiority trial design with change of body mass index (BMI) as primary endpoint. Methods This prospective, randomized, double-blind study was conducted at the Charité, Berlin, Germany, from 02/2008 until 01/2014. Adult patients (n = 42; aged 18 to 80 years) requiring HPN for at least 8 weeks were randomly assigned to the test or control group. Assessments included weight, height, physical examination (cardiovascular system, abdomen, respiratory tract, liver, spleen, kidney, urine tract, skin, mucous membrane, neurology, psyche, musculoskeletal system, lymph nodes), bio impedance analysis, calorimetry, blood samplings (haematology, biochemistry, fatty acid analysis) and quality of life questionnaire. Results BMI increased in both groups with 8 weeks of HPN (ΔBMI(test group) = 1.3 ± 1.1 kg/m2; ΔBMI(control group) = 0.6 ± 0.9 kg/m2) demonstrating non-inferiority of the test regimen regarding nutritional efficacy. Assessment of secondary efficacy endpoints revealed that after 8 weeks of HPN with the test regimen, the proportion of n-3 PUFAs in serum, platelet and red blood cell phospholipids significantly increased, while the proportion of n-6 PUFAs decreased. The fatty acid pattern in the control group remained mostly stable. No statistically significant differences were detected between groups regarding inflammatory markers or quality of life. Laboratory parameters reflecting the safety endpoints liver function, bone metabolism, renal function, metabolic activity, lipid metabolism, coagulation and haematology were stable in both groups and no group differences were detected regarding (serious) adverse events. Conclusions The HPN regimen prepared with MCT/LCT/FO-derived n-3 PUFAs was at least as efficient in maintaining or even improving nutritional status during HPN as the control MCT/LCT regimen. Administration of FO-derived n-3 PUFAs for 8 weeks altered the fatty acid pattern of serum, platelet and red blood cell phospholipids. Both regimens were safe and well tolerated. Trial registration www.clinicaltrials.gov, registration number: NCT00530738.

El artículo analiza las estrategias de control de la “vagancia” desde una perspectiva sociohistórica. Se identifican cuatro períodos -desde la creación del Estado oriental hasta nuestros días- donde el problema de la vagancia fue objeto de preocupación, se caracterizan brevemente los contextos históricos específicos así como las estrategias de control desplegadas y su significación sociopolítica. La relación entre el control de la vagancia y las demandas de fuerza de trabajo (en mercados o cuasi mercados laborales, según el período) resulta un analizador central para comprender el papel del Estado en la configuración de un orden social más o menos coherente con las particulares dinámicas de acumulación. Se propone aproximar una respuesta a la interrogante de si es posible trazar una línea de continuidad entre la aprobación de la Ley de Faltas (N° 19.120) a comienzos del siglo XXI y las disposiciones de control de la vagancia en el siglo XIX. Abstract: The article analyzes the strategies of control of «vagrancy» from a sociohistorical perspective. It identifies four periods - from the creation of the Eastern State to our days - where the problem of vagrancy was a concern, briefly characterize the specific historical contexts as well as the control strategies deployed and their socio-political significance. The relationship between vagrancy control and labor force demands (in markets or quasi labor markets, depending on the period) is a central analyzer to understand the role of the State in shaping a social order more or less coherent with particular dynamics of accumulation. It is proposed to approximate a response to the question of whether it is possible to draw a line of continuity between the approval of the Law of Faults (Nº. 19.120) at the beginning of the 21st century and the provisions of control of vagrancy in the nineteenth century. Keywords: Vagrancy. Work. State.

Chronic inflammation is a hallmark of atherosclerosis and results from an imbalance between proinflammatory and proresolving signaling. The human GPR32 receptor, together with the ALX/FPR2 receptor, transduces biological actions of several proresolving mediators that stimulate resolution of inflammation. However, since no murine homologs of the human GPR32 receptor exist, comprehensive in vivo studies are lacking. Using human atherosclerotic lesions from carotid endarterectomies and creating a transgenic mouse model expressing human GPR32 on a Fpr2xApoE doubleKO background ([hGPR32.sub.myc] * [Fpr.sup.2-/-] * [Apoe.sup.-/-]), we investigated the role of GPR32 in atherosclerosis and self-limiting acute inflammation. GPR32 mRNA was reduced in human atherosclerotic lesions and correlated with the immune cell markers ARG1, NOS2, and FOXP3. Atherosclerotic lesions, necrotic core, and aortic inflammation were reduced in [hGPR32.sub.myc]Tg * [Fpr2.sup.-/-] * [Apoe.sup.-/-] transgenic mice as compared with [Fpr2.sup.-/-] * [Apoe.sup.-/-] nontransgenic littermates. In a zymosan-induced peritonitis model, the [hGPR32.sub.myc]Tg * [Fpr2.sub.-/-] * [Apoe.sub.-/-] transgenic mice had reduced inflammation at 4 hours and enhanced proresolving macrophage responses at 24 hours compared with nontransgenic littermates. The GPR32 agonist aspirin-triggered resolvin D1 (AT-RvD1) regulated leukocyte responses, including enhancing macrophage phagocytosis and intracellular signaling in [hGPR32.sub.myc]Tg * [Fpr2.sup.-/-] * [Apoe.sup.-/-] transgenic mice, but not in [Fpr2.sup.-/-] * [Apoe.sup.-/-] nontransgenic littermates. Together, these results provide evidence that GPR32 regulates resolution of inflammation and is atheroprotective in vivo., Introduction Resolution of acute inflammation is an active, coordinated response aimed at terminating the inflammatory response and restoring tissue homeostasis (1). Resolution of inflammation is regulated by a superfamily of [...]

Background: Fecal microbiota, live-jslm (RBL; REBYOTA®), is the first Food and Drug Administration (FDA)-approved, single-dose, rectally administered, microbiota-based live biotherapeutic product for preventing Clostridioides difficile infection (CDI) recurrence. Alternative routes of administration are of clinical interest. Objectives: Evaluate the safety and efficacy of RBL administration via colonoscopy. Design: Retrospective analysis of electronic medical records of participants administered RBL via colonoscopy under FDA enforcement discretion. Methods: The number of participants with treatment and/or procedure-emergent adverse events (TEAEs) was evaluated. Treatment success and sustained clinical response, defined as the absence of CDI recurrence within 8 weeks and 6 months, respectively, were evaluated. Results: TEAEs were experienced by 75% (6/8) of participants; most were mild to moderate in severity, and none due to RBL or its administration. Most participants had treatment success (80%; 8/10); 75% (6/8) had sustained clinical response. Conclusion: Real-world safety and efficacy of RBL administered via colonoscopy were consistent with clinical trials of rectally administered RBL. [ABSTRACT FROM AUTHOR]

This article discusses a case report of a neonate with severe left heart failure after neonatal myocardial infarction. The patient underwent various treatments, including thrombolysis, inotropic therapy, and prostaglandin E1, to stabilize their condition. A hybrid treatment involving stenting of the arterial duct and bilateral pulmonary banding was performed as a bridge to recovery or transplantation. Eventually, the patient received a successful heart transplant after a waiting time of ten months. The case highlights the importance of adjusting therapeutic strategies to maintain sufficient cardiac output and the need to avoid extracorporeal circulation in neonatal heart failure to reduce morbidity and mortality. [Extracted from the article]

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Este artículo pretende analizar las experiencias de colonización canaria impulsadas por particulares y con respaldo del Estado uruguayo durante la década de 1830. Se trata de un tipo especial de inmigración, ya que los individuos firmaban un contrato que los obligaba a permanecer trabajando en Uruguay hasta saldar la deuda de su pasaje desde Europa. El Estado, a través de la policía, actuaba como garante del cumplimiento de los contratos.

La consolidación de una sociedad capitalista a fines del siglo XIX y la llegada de inmigrantes europeos con militancia de izquierda se presentan habitualmente como los factores clave para comprender el origen del movimiento obrero argentino y uruguayo, en los que las primeras huelgas se habrían iniciado a partir de 1878. Todo esto tiene una importancia indudable, pero encuadra esta historia en el “tiempo corto”. ¿Alcanza con él para explicar las prácticas del movimiento obrero emergente? Este artículo plantea la conveniencia de rastrear las formas de protesta y resistencia de los trabajadores en el largo plazo, considerando la interacción entre coacción, mercado y acciones colectivas, las huelgas anteriores a 1878, las disputas laborales en el ámbito militar, y otras formas de conflicto.