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101. Supplementary Table 2 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Nebbioso, Angela, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Tambaro, Francesco Paolo, primary, Abbondanza, Ciro, primary, Martens, Joost, primary, Nees, Matthias, primary, Benedetti, Rosaria, primary, Pallavicini, Isabella, primary, Minucci, Saverio, primary, Garcia-Manero, Guillermo, primary, Iovino, Francesco, primary, Lania, Gabriella, primary, Ingenito, Concetta, primary, Belsito Petrizzi, Valeria, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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102. Supplementary Figure 3 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Nebbioso, Angela, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Tambaro, Francesco Paolo, primary, Abbondanza, Ciro, primary, Martens, Joost, primary, Nees, Matthias, primary, Benedetti, Rosaria, primary, Pallavicini, Isabella, primary, Minucci, Saverio, primary, Garcia-Manero, Guillermo, primary, Iovino, Francesco, primary, Lania, Gabriella, primary, Ingenito, Concetta, primary, Belsito Petrizzi, Valeria, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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103. Supplementary Figure 5 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Nebbioso, Angela, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Tambaro, Francesco Paolo, primary, Abbondanza, Ciro, primary, Martens, Joost, primary, Nees, Matthias, primary, Benedetti, Rosaria, primary, Pallavicini, Isabella, primary, Minucci, Saverio, primary, Garcia-Manero, Guillermo, primary, Iovino, Francesco, primary, Lania, Gabriella, primary, Ingenito, Concetta, primary, Belsito Petrizzi, Valeria, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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104. Suppl. Methods from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Nebbioso, Angela, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Tambaro, Francesco Paolo, primary, Abbondanza, Ciro, primary, Martens, Joost, primary, Nees, Matthias, primary, Benedetti, Rosaria, primary, Pallavicini, Isabella, primary, Minucci, Saverio, primary, Garcia-Manero, Guillermo, primary, Iovino, Francesco, primary, Lania, Gabriella, primary, Ingenito, Concetta, primary, Belsito Petrizzi, Valeria, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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105. Supplementary Figure 1 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Nebbioso, Angela, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Tambaro, Francesco Paolo, primary, Abbondanza, Ciro, primary, Martens, Joost, primary, Nees, Matthias, primary, Benedetti, Rosaria, primary, Pallavicini, Isabella, primary, Minucci, Saverio, primary, Garcia-Manero, Guillermo, primary, Iovino, Francesco, primary, Lania, Gabriella, primary, Ingenito, Concetta, primary, Belsito Petrizzi, Valeria, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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106. Supplementary Figure 2 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Nebbioso, Angela, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Tambaro, Francesco Paolo, primary, Abbondanza, Ciro, primary, Martens, Joost, primary, Nees, Matthias, primary, Benedetti, Rosaria, primary, Pallavicini, Isabella, primary, Minucci, Saverio, primary, Garcia-Manero, Guillermo, primary, Iovino, Francesco, primary, Lania, Gabriella, primary, Ingenito, Concetta, primary, Belsito Petrizzi, Valeria, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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107. Supplementary Figures from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer

Author

Carafa, Vincenzo, primary, Nebbioso, Angela, primary, Cuomo, Francesca, primary, Rotili, Dante, primary, Cobellis, Gilda, primary, Bontempo, Paola, primary, Baldi, Alfonso, primary, Spugnini, Enrico P., primary, Citro, Gennaro, primary, Chambery, Angela, primary, Russo, Rosita, primary, Ruvo, Menotti, primary, Ciana, Paolo, primary, Maravigna, Luca, primary, Shaik, Jani, primary, Radaelli, Enrico, primary, De Antonellis, Pasquale, primary, Tarantino, Domenico, primary, Pirolli, Adele, primary, Ragno, Rino, primary, Zollo, Massimo, primary, Stunnenberg, Hendrik G., primary, Mai, Antonello, primary, and Altucci, Lucia, primary

Published
2023
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108. Supplementary Figure 8 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Nebbioso, Angela, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Tambaro, Francesco Paolo, primary, Abbondanza, Ciro, primary, Martens, Joost, primary, Nees, Matthias, primary, Benedetti, Rosaria, primary, Pallavicini, Isabella, primary, Minucci, Saverio, primary, Garcia-Manero, Guillermo, primary, Iovino, Francesco, primary, Lania, Gabriella, primary, Ingenito, Concetta, primary, Belsito Petrizzi, Valeria, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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109. Supplementary Figure 4 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Nebbioso, Angela, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Tambaro, Francesco Paolo, primary, Abbondanza, Ciro, primary, Martens, Joost, primary, Nees, Matthias, primary, Benedetti, Rosaria, primary, Pallavicini, Isabella, primary, Minucci, Saverio, primary, Garcia-Manero, Guillermo, primary, Iovino, Francesco, primary, Lania, Gabriella, primary, Ingenito, Concetta, primary, Belsito Petrizzi, Valeria, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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110. Supplementary Tables from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer

Author

Carafa, Vincenzo, primary, Nebbioso, Angela, primary, Cuomo, Francesca, primary, Rotili, Dante, primary, Cobellis, Gilda, primary, Bontempo, Paola, primary, Baldi, Alfonso, primary, Spugnini, Enrico P., primary, Citro, Gennaro, primary, Chambery, Angela, primary, Russo, Rosita, primary, Ruvo, Menotti, primary, Ciana, Paolo, primary, Maravigna, Luca, primary, Shaik, Jani, primary, Radaelli, Enrico, primary, De Antonellis, Pasquale, primary, Tarantino, Domenico, primary, Pirolli, Adele, primary, Ragno, Rino, primary, Zollo, Massimo, primary, Stunnenberg, Hendrik G., primary, Mai, Antonello, primary, and Altucci, Lucia, primary

Published
2023
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111. Supplementary Table 1 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Nebbioso, Angela, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Tambaro, Francesco Paolo, primary, Abbondanza, Ciro, primary, Martens, Joost, primary, Nees, Matthias, primary, Benedetti, Rosaria, primary, Pallavicini, Isabella, primary, Minucci, Saverio, primary, Garcia-Manero, Guillermo, primary, Iovino, Francesco, primary, Lania, Gabriella, primary, Ingenito, Concetta, primary, Belsito Petrizzi, Valeria, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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112. Supplementary Figure 6 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Nebbioso, Angela, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Tambaro, Francesco Paolo, primary, Abbondanza, Ciro, primary, Martens, Joost, primary, Nees, Matthias, primary, Benedetti, Rosaria, primary, Pallavicini, Isabella, primary, Minucci, Saverio, primary, Garcia-Manero, Guillermo, primary, Iovino, Francesco, primary, Lania, Gabriella, primary, Ingenito, Concetta, primary, Belsito Petrizzi, Valeria, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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113. Supplementary note from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer

Author

Carafa, Vincenzo, primary, Nebbioso, Angela, primary, Cuomo, Francesca, primary, Rotili, Dante, primary, Cobellis, Gilda, primary, Bontempo, Paola, primary, Baldi, Alfonso, primary, Spugnini, Enrico P., primary, Citro, Gennaro, primary, Chambery, Angela, primary, Russo, Rosita, primary, Ruvo, Menotti, primary, Ciana, Paolo, primary, Maravigna, Luca, primary, Shaik, Jani, primary, Radaelli, Enrico, primary, De Antonellis, Pasquale, primary, Tarantino, Domenico, primary, Pirolli, Adele, primary, Ragno, Rino, primary, Zollo, Massimo, primary, Stunnenberg, Hendrik G., primary, Mai, Antonello, primary, and Altucci, Lucia, primary

Published
2023
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114. On line Materials and Methods from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer

Author

Carafa, Vincenzo, primary, Nebbioso, Angela, primary, Cuomo, Francesca, primary, Rotili, Dante, primary, Cobellis, Gilda, primary, Bontempo, Paola, primary, Baldi, Alfonso, primary, Spugnini, Enrico P., primary, Citro, Gennaro, primary, Chambery, Angela, primary, Russo, Rosita, primary, Ruvo, Menotti, primary, Ciana, Paolo, primary, Maravigna, Luca, primary, Shaik, Jani, primary, Radaelli, Enrico, primary, De Antonellis, Pasquale, primary, Tarantino, Domenico, primary, Pirolli, Adele, primary, Ragno, Rino, primary, Zollo, Massimo, primary, Stunnenberg, Hendrik G., primary, Mai, Antonello, primary, and Altucci, Lucia, primary

Published
2023
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115. Supplementary Figure 7 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Nebbioso, Angela, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Tambaro, Francesco Paolo, primary, Abbondanza, Ciro, primary, Martens, Joost, primary, Nees, Matthias, primary, Benedetti, Rosaria, primary, Pallavicini, Isabella, primary, Minucci, Saverio, primary, Garcia-Manero, Guillermo, primary, Iovino, Francesco, primary, Lania, Gabriella, primary, Ingenito, Concetta, primary, Belsito Petrizzi, Valeria, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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116. Supplementary Figure 1 from Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392

Author

De Bellis, Floriana, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Rotili, Dante, primary, Petraglia, Francesca, primary, Matarese, Filomena, primary, Françoijs, Kees-Jan, primary, Ablain, Julien, primary, Valente, Sergio, primary, Castellano, Rèmy, primary, Goubard, Armelle, primary, Collette, Yves, primary, Mandoli, Amit, primary, Martens, Joost H.A., primary, de Thé, Hugues, primary, Nebbioso, Angela, primary, Mai, Antonello, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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117. Data from Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392

Author

De Bellis, Floriana, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Rotili, Dante, primary, Petraglia, Francesca, primary, Matarese, Filomena, primary, Françoijs, Kees-Jan, primary, Ablain, Julien, primary, Valente, Sergio, primary, Castellano, Rèmy, primary, Goubard, Armelle, primary, Collette, Yves, primary, Mandoli, Amit, primary, Martens, Joost H.A., primary, de Thé, Hugues, primary, Nebbioso, Angela, primary, Mai, Antonello, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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118. Supplementary Figure 2 from Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392

Author

De Bellis, Floriana, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Rotili, Dante, primary, Petraglia, Francesca, primary, Matarese, Filomena, primary, Françoijs, Kees-Jan, primary, Ablain, Julien, primary, Valente, Sergio, primary, Castellano, Rèmy, primary, Goubard, Armelle, primary, Collette, Yves, primary, Mandoli, Amit, primary, Martens, Joost H.A., primary, de Thé, Hugues, primary, Nebbioso, Angela, primary, Mai, Antonello, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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119. Supplementary Materials and Methods, Tables 1 - 3 from Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392

Author

De Bellis, Floriana, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Rotili, Dante, primary, Petraglia, Francesca, primary, Matarese, Filomena, primary, Françoijs, Kees-Jan, primary, Ablain, Julien, primary, Valente, Sergio, primary, Castellano, Rèmy, primary, Goubard, Armelle, primary, Collette, Yves, primary, Mandoli, Amit, primary, Martens, Joost H.A., primary, de Thé, Hugues, primary, Nebbioso, Angela, primary, Mai, Antonello, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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120. Supplementary Figure 4 from Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392

Author

De Bellis, Floriana, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Rotili, Dante, primary, Petraglia, Francesca, primary, Matarese, Filomena, primary, Françoijs, Kees-Jan, primary, Ablain, Julien, primary, Valente, Sergio, primary, Castellano, Rèmy, primary, Goubard, Armelle, primary, Collette, Yves, primary, Mandoli, Amit, primary, Martens, Joost H.A., primary, de Thé, Hugues, primary, Nebbioso, Angela, primary, Mai, Antonello, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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121. Supplementary Figure 3 from Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392

Author

De Bellis, Floriana, primary, Carafa, Vincenzo, primary, Conte, Mariarosaria, primary, Rotili, Dante, primary, Petraglia, Francesca, primary, Matarese, Filomena, primary, Françoijs, Kees-Jan, primary, Ablain, Julien, primary, Valente, Sergio, primary, Castellano, Rèmy, primary, Goubard, Armelle, primary, Collette, Yves, primary, Mandoli, Amit, primary, Martens, Joost H.A., primary, de Thé, Hugues, primary, Nebbioso, Angela, primary, Mai, Antonello, primary, Stunnenberg, Hendrik G., primary, and Altucci, Lucia, primary

Published
2023
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123. Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells

Author

Di Bello, Elisabetta, primary, Sian, Veronica, additional, Bontempi, Giulio, additional, Zwergel, Clemens, additional, Fioravanti, Rossella, additional, Noce, Beatrice, additional, Castiello, Carola, additional, Tomassi, Stefano, additional, Corinti, Davide, additional, Passeri, Daniela, additional, Pellicciari, Roberto, additional, Mercurio, Ciro, additional, Varasi, Mario, additional, Altucci, Lucia, additional, Tripodi, Marco, additional, Strippoli, Raffaele, additional, Nebbioso, Angela, additional, Valente, Sergio, additional, and Mai, Antonello, additional

Published
2023
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129. Data from Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008

Author

Lucia Altucci, Hinrich Gronemeyer, Angel R. de Lera, Hendrik G. Stunnenberg, Felicetto Ferrara, Valerie Kedinger, Colin Logie, Marco Miceli, José García-Rodríguez, Filomena Matarese, Harshal Khanwalkar, Raquel Pereira, and Angela Nebbioso

Abstract

Deregulation of the epigenome is recognized as cause of cancer and epigenetic factors are receiving major attention as therapeutic targets; yet, the molecular mode of action of existing epi-drugs is largely elusive. Here, we report on the decryption of the mechanism of action of UVI5008, a novel epigenetic modifier, that inhibits histone deacetylases, sirtuins, and DNA methyltransferases. UVI5008 highly efficiently induces cancer cell–selective death in a variety of models and exerts its activities in several human tumor xenografts and genetic mouse models of human breast cancer in vivo. Its anticancer activity involves independent activation of death receptors and reactive oxygen species production. Importantly, UVI5008 action is not critically dependent on p53, Bcl-2 modifying factor, and/or TNF-related apoptosis-inducing ligand as cell death is efficiently induced in cells mutated or deficient for these factors limiting the risk of drug resistance development and maximizing its application spectrum. The simultaneous modulation of multiple (epigenetic) targets promises to open new avenues with unanticipated potential against cancer. Mol Cancer Ther; 10(12); 2394–404. ©2011 AACR.

Published
2023
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134. Data from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Lucia Altucci, Hendrik G. Stunnenberg, Valeria Belsito Petrizzi, Concetta Ingenito, Gabriella Lania, Francesco Iovino, Guillermo Garcia-Manero, Saverio Minucci, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Joost Martens, Ciro Abbondanza, Francesco Paolo Tambaro, Mariarosaria Conte, Vincenzo Carafa, and Angela Nebbioso

Abstract

Purpose: Histone deacetylase inhibitors (HDACi) are promising anticancer drugs. Although some HDACi have entered the clinic, the mechanism(s) underlying their tumor selectivity are poorly understood.Experimental Design and Results: Using gene expression analysis, we define a core set of six genes commonly regulated in acute myeloid leukemia (AML) blasts and cell lines. MYC, the most prominently modulated, is preferentially altered in leukemia. Upon HDACi treatment, c-Myc is acetylated at lysine 323 and its expression decreases, leading to TRAIL activation and apoptosis. c-Myc binds to the TRAIL promoter on the proximal GC box through SP1 or MIZ1, impairing TRAIL activation. HDACi exposure triggers TRAIL expression, altering c-Myc-TRAIL binding. These events do not occur in normal cells. Excitingly, this inverse correlation between TRAIL and c-Myc is supported by HDACi treatment ex vivo of AML blasts and primary human breast cancer cells. The predictive value of c-Myc to HDACi responsiveness is confirmed in vivo in AML patients undergoing HDACi-based clinical trials.Conclusions: Collectively, our findings identify a key role for c-Myc in TRAIL deregulation and as a biomarker of the anticancer action of HDACi in AML. The potential improved patient stratification could pave the way toward personalized therapies. Clin Cancer Res; 23(10); 2542–55. ©2016 AACR.

Published
2023
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135. Supplementary note from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer

Author

Lucia Altucci, Antonello Mai, Hendrik G. Stunnenberg, Massimo Zollo, Rino Ragno, Adele Pirolli, Domenico Tarantino, Pasquale De Antonellis, Enrico Radaelli, Jani Shaik, Luca Maravigna, Paolo Ciana, Menotti Ruvo, Rosita Russo, Angela Chambery, Gennaro Citro, Enrico P. Spugnini, Alfonso Baldi, Paola Bontempo, Gilda Cobellis, Dante Rotili, Francesca Cuomo, Angela Nebbioso, and Vincenzo Carafa

Abstract

supplementary chemistry

Published
2023
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136. Supplementary Figure 7 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Lucia Altucci, Hendrik G. Stunnenberg, Valeria Belsito Petrizzi, Concetta Ingenito, Gabriella Lania, Francesco Iovino, Guillermo Garcia-Manero, Saverio Minucci, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Joost Martens, Ciro Abbondanza, Francesco Paolo Tambaro, Mariarosaria Conte, Vincenzo Carafa, and Angela Nebbioso

Abstract

SAHA effects in different cell lines.

Published
2023
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137. Supplementary Tables from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer

Author

Lucia Altucci, Antonello Mai, Hendrik G. Stunnenberg, Massimo Zollo, Rino Ragno, Adele Pirolli, Domenico Tarantino, Pasquale De Antonellis, Enrico Radaelli, Jani Shaik, Luca Maravigna, Paolo Ciana, Menotti Ruvo, Rosita Russo, Angela Chambery, Gennaro Citro, Enrico P. Spugnini, Alfonso Baldi, Paola Bontempo, Gilda Cobellis, Dante Rotili, Francesca Cuomo, Angela Nebbioso, and Vincenzo Carafa

Abstract

Supplementary Tables

Published
2023
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138. Supplementary Table 1 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Lucia Altucci, Hendrik G. Stunnenberg, Valeria Belsito Petrizzi, Concetta Ingenito, Gabriella Lania, Francesco Iovino, Guillermo Garcia-Manero, Saverio Minucci, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Joost Martens, Ciro Abbondanza, Francesco Paolo Tambaro, Mariarosaria Conte, Vincenzo Carafa, and Angela Nebbioso

Abstract

Schematic representation of the TRAIL promoter, its analyzed regions and the occupancy of epi-marks analyzed under indicated conditions.

Published
2023
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139. Supplementary Figure 4 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Lucia Altucci, Hendrik G. Stunnenberg, Valeria Belsito Petrizzi, Concetta Ingenito, Gabriella Lania, Francesco Iovino, Guillermo Garcia-Manero, Saverio Minucci, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Joost Martens, Ciro Abbondanza, Francesco Paolo Tambaro, Mariarosaria Conte, Vincenzo Carafa, and Angela Nebbioso

Abstract

Epigenetic status of the TRAIL promoter region after HDACi exposure.

Published
2023
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140. On line Materials and Methods from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer

Author

Lucia Altucci, Antonello Mai, Hendrik G. Stunnenberg, Massimo Zollo, Rino Ragno, Adele Pirolli, Domenico Tarantino, Pasquale De Antonellis, Enrico Radaelli, Jani Shaik, Luca Maravigna, Paolo Ciana, Menotti Ruvo, Rosita Russo, Angela Chambery, Gennaro Citro, Enrico P. Spugnini, Alfonso Baldi, Paola Bontempo, Gilda Cobellis, Dante Rotili, Francesca Cuomo, Angela Nebbioso, and Vincenzo Carafa

Abstract

On line Materials and Methods

Published
2023
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141. Supplementary Figure 3 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Lucia Altucci, Hendrik G. Stunnenberg, Valeria Belsito Petrizzi, Concetta Ingenito, Gabriella Lania, Francesco Iovino, Guillermo Garcia-Manero, Saverio Minucci, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Joost Martens, Ciro Abbondanza, Francesco Paolo Tambaro, Mariarosaria Conte, Vincenzo Carafa, and Angela Nebbioso

Abstract

c-Myc down-regulation modulates DR5 and p21 genes.

Published
2023
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142. Supplementary Figure 8 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Lucia Altucci, Hendrik G. Stunnenberg, Valeria Belsito Petrizzi, Concetta Ingenito, Gabriella Lania, Francesco Iovino, Guillermo Garcia-Manero, Saverio Minucci, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Joost Martens, Ciro Abbondanza, Francesco Paolo Tambaro, Mariarosaria Conte, Vincenzo Carafa, and Angela Nebbioso

Abstract

SAHA effects in normal cells.

Published
2023
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143. Suppl. Methods from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Lucia Altucci, Hendrik G. Stunnenberg, Valeria Belsito Petrizzi, Concetta Ingenito, Gabriella Lania, Francesco Iovino, Guillermo Garcia-Manero, Saverio Minucci, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Joost Martens, Ciro Abbondanza, Francesco Paolo Tambaro, Mariarosaria Conte, Vincenzo Carafa, and Angela Nebbioso

Abstract

Suppl. Methods

Published
2023
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144. Data from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer

Author

Lucia Altucci, Antonello Mai, Hendrik G. Stunnenberg, Massimo Zollo, Rino Ragno, Adele Pirolli, Domenico Tarantino, Pasquale De Antonellis, Enrico Radaelli, Jani Shaik, Luca Maravigna, Paolo Ciana, Menotti Ruvo, Rosita Russo, Angela Chambery, Gennaro Citro, Enrico P. Spugnini, Alfonso Baldi, Paola Bontempo, Gilda Cobellis, Dante Rotili, Francesca Cuomo, Angela Nebbioso, and Vincenzo Carafa

Abstract

Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes.Experimental Design: We have investigated the role of RIP1 and the effects of MC2494 in cell death induction, using different methods as flow cytometry, transcriptome analysis, immunoprecipitation, enzymatic assays, transfections, mutagenesis, and in vivo studies with different mice models.Results: Here, we show that RIP1 is highly expressed in cancer, and we define a novel RIP1/3–SIRT1/2–HAT1/4 complex. Mass spectrometry identified five acetylations in the kinase and death domain of RIP1. The novel characterized pan-SIRT inhibitor, MC2494, increases RIP1 acetylation at two additional sites in the death domain. Mutagenesis of the acetylated lysine decreases RIP1-dependent cell death, suggesting a role for acetylation of the RIP1 complex in cell death modulation. Accordingly, MC2494 displays tumor-selective potential in vitro, in leukemic blasts ex vivo, and in vivo in both xenograft and allograft cancer models. Mechanistically, MC2494 induces bona fide tumor-restricted acetylated RIP1/caspase-8–mediated apoptosis. Excitingly, MC2494 displays tumor-preventive activity by blocking 7,12-dimethylbenz(α)anthracene–induced mammary gland hyperproliferation in vivo.Conclusions: These preventive features might prove useful in patients who may benefit from a recurrence-preventive approach with low toxicity during follow-up phases and in cases of established cancer predisposition. Thus, targeting the newly identified RIP1 complex may represent an attractive novel paradigm in cancer treatment and prevention. Clin Cancer Res; 24(12); 2886–900. ©2018 AACR.

Published
2023
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145. Supplementary Figure 6 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Lucia Altucci, Hendrik G. Stunnenberg, Valeria Belsito Petrizzi, Concetta Ingenito, Gabriella Lania, Francesco Iovino, Guillermo Garcia-Manero, Saverio Minucci, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Joost Martens, Ciro Abbondanza, Francesco Paolo Tambaro, Mariarosaria Conte, Vincenzo Carafa, and Angela Nebbioso

Abstract

HDACI-specific effects on c-Myc acetylation.

Published
2023
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146. Supplementary Figure 2 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Lucia Altucci, Hendrik G. Stunnenberg, Valeria Belsito Petrizzi, Concetta Ingenito, Gabriella Lania, Francesco Iovino, Guillermo Garcia-Manero, Saverio Minucci, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Joost Martens, Ciro Abbondanza, Francesco Paolo Tambaro, Mariarosaria Conte, Vincenzo Carafa, and Angela Nebbioso

Abstract

Effects of c-Myc overexpression, p21shRNA and TRAILshRNA (A).

Published
2023
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147. Supplementary Table 2 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Lucia Altucci, Hendrik G. Stunnenberg, Valeria Belsito Petrizzi, Concetta Ingenito, Gabriella Lania, Francesco Iovino, Guillermo Garcia-Manero, Saverio Minucci, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Joost Martens, Ciro Abbondanza, Francesco Paolo Tambaro, Mariarosaria Conte, Vincenzo Carafa, and Angela Nebbioso

Abstract

Primer sequence, location and product of amplification size.

Published
2023
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148. Supplementary Figures from RIP1–HAT1–SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer

Author

Lucia Altucci, Antonello Mai, Hendrik G. Stunnenberg, Massimo Zollo, Rino Ragno, Adele Pirolli, Domenico Tarantino, Pasquale De Antonellis, Enrico Radaelli, Jani Shaik, Luca Maravigna, Paolo Ciana, Menotti Ruvo, Rosita Russo, Angela Chambery, Gennaro Citro, Enrico P. Spugnini, Alfonso Baldi, Paola Bontempo, Gilda Cobellis, Dante Rotili, Francesca Cuomo, Angela Nebbioso, and Vincenzo Carafa

Abstract

Supplementary Figures

Published
2023
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149. Supplementary Figure 5 from c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Author

Lucia Altucci, Hendrik G. Stunnenberg, Valeria Belsito Petrizzi, Concetta Ingenito, Gabriella Lania, Francesco Iovino, Guillermo Garcia-Manero, Saverio Minucci, Isabella Pallavicini, Rosaria Benedetti, Matthias Nees, Joost Martens, Ciro Abbondanza, Francesco Paolo Tambaro, Mariarosaria Conte, Vincenzo Carafa, and Angela Nebbioso

Abstract

HDACi effects in different cell lines.

Published
2023
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150. Supplementary Figure 2 from Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392

Author

Lucia Altucci, Hendrik G. Stunnenberg, Antonello Mai, Angela Nebbioso, Hugues de Thé, Joost H.A. Martens, Amit Mandoli, Yves Collette, Armelle Goubard, Rèmy Castellano, Sergio Valente, Julien Ablain, Kees-Jan Françoijs, Filomena Matarese, Francesca Petraglia, Dante Rotili, Mariarosaria Conte, Vincenzo Carafa, and Floriana De Bellis

Abstract

PDF file - 147KB, Differences in gene expression between ATRA and MC2392.

Published
2023
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