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—Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain; it plays an important role in various types of synaptic plasticity and pathology. In the present work, proton magnetic resonance spectroscopy (1H-MRS) and two modified MEGA-PRESS pulse sequences, that is, –GABAMEGA-PRESS and +GABAMEGA-PRESS, were used to investigate the effect of visual stimulation on the GABA level in the human visual cortex in vivo. With –GABAMEGA-PRESS, it was possible to acquire the 1H-NMR signal of methylated protons of GABA with the chemical shift δ = 3.01 ppm without the signals from macromolecules. When +GABAMEGA-PRESS was used, the GABA signal was a superposition of resonances of methylene protons of GABA and macromolecules. The effect of constant visual stimulation on the level of N-acetylaspartate and total level of glutamate and glutamine was also estimated. Constant visual stimulation had no effect on the levels of N-acetylaspartate and glutamine in the visual cortex. The –GABA signal intensity decreased with a statistically significant decrease in the level of GABA signal intensity leading to inactivation of GABA synthesis. No statistically significant changes in the intensity of the +GABA resonance were found, probably due to the effect of visual stimulation on macromolecules. In order to test this hypothesis, a signal from macromolecules was acquired using a specifically designed inversion-recovery pulse sequence. It was shown that the intensity of this signal is unaffected by visual stimulation and the absence of changes in the intensity of the +GABA signal during the stimulation has to be considered as the masking effect of macromolecular signal.

The electrical conductivity of pseudohexagonal ε(κ)-Ga2O3 films under different ambient gases (H2, NO2, O2, and CO) is studied in a range of temperatures from 400 to 550 °C. The exposure of ε(κ)-Ga2O3 to reducing gases such as H2 and CO results in a reversible increase in current and conductance. The exposure to the oxidizing gases such as NO2 and O2 has the opposite effect. The maximum response to reducing gases (H2 and CO) is observed at 500 °C and to oxidizing gases at 550 and 450 °C for NO2 and O2, respectively. The highest sensitivity to H2 is achieved at low applied voltages (≤7.9 V). In contrast, the highest sensitivity to NO2 is observed at high applied voltages. The response and recovery times and temporal drift of ε(κ)-Ga2O3 characteristics under different ambient are estimated. Polycrystalline ε(κ)-Ga2O3 exhibits the semiconducting mechanism of electron transport at high temperatures. A qualitative model of the gas-sensing effect based on the modulation of electron concentration near the surface region of ε(κ)-Ga2O3 due to the chemisorption of gas molecules is described. Tin doping of ε(κ)-Ga2O3 increases the response to H2 at the temperature range from 25 to 550 °C.

TiO2 films of 130 nm and 463 nm in thickness were deposited by ion beam sputter deposition (IBSD), followed by annealing at temperatures of 800 °C and 1000 °C. The effect of H2, CO, CO2, NO2, NO, CH4 and O2 on the electrically conductive properties of annealed TiO2 thin films in the operating temperature range of 200–750 °C were studied. The prospects of IBSD deposited TiO2 thin films in the development of high operating temperature and high stability O2 sensors were investigated. TiO2 films with a thickness of 130 nm and annealed at 800 °C demonstrated the highest response to O2, of 7.5 arb.un. when exposed to 40 vol. %. An increase in the annealing temperature of up to 1000 °C at the same film thickness made it possible to reduce the response and recovery by 2 times, due to changes in the microstructure of the film surface. The films demonstrated high sensitivity to H2 and nitrogen oxides at an operating temperature of 600 °C. The possibility of controlling the responses to different gases by varying the conditions of their annealing and thicknesses was shown. A feasible mechanism for the sensory effect in the IBSD TiO2 thin films was proposed and discussed.

This paper considers development of positioning systems for manipulator links to solve the forward kinematics problem (FKP) and inverse kinematics problem (IKP). Here we study a robotic manipulator with four degrees of freedom. It should be noted, that one of the relevant research problems of modern modular robotic devices consists in the lack of the universal algorithms, that would ensure kinematics problem recalculations in the cases of reconfigurations of the whole system. Challenges, the researchers are facing with when solving this problem, have to do with geometrical and non-linear equations (trigonometric equations), finding of inverse matrix of the Denavit—Hartenberg presentation, as well with other problems, such as multiple solutions when using the analytical approach. Common mathematical solutions of the inverse kinematics problem, such as geometric, iterative and algebraic ones, may not always lead to physically appropriate solutions. It’s also noteworthy, that, trying to introduce physical solutions for the manipulator, we need to take into account, that the number of calculation formulas increases, what, in turn, causes further computing power consumption increase. If the manipulator acquires additional degrees of freedom, analytical modeling becomes virtually impossible. One of relevant inverse kinematics solution methods consists in implementation of neural networks to that end. To solve this problem various sources were analyzed, considering alternative ways of target point discovery. Considering the analyzed papers, we propose to use a perceptron. Before training the network, we compose an algorithm, calculating the Denavit—Hartman presentation matrix and check for correctness of target point reach by the terminal manipulator link. We did calculations for a thousand positions of manipulator and object in the environment, fed to the neural network. When solving FKP we obtain object coordinates as network output, whereas in the case of IKP — manipulator link angles. We present kinematic scheme testing results, as well a control scheme for a manipulator with four degrees of freedom.

Genetics and environmental and lifestyle factors deeply affect cardiovascular diseases, with atherosclerosis as the etiopathological factor (ACVD) and their early recognition can significantly contribute to an efficient prevention and treatment of the disease. Due to the vast number of these factors, only the novel “omic” approaches are surmised. In addition to genomics, which extended the effective therapeutic potential for complex and rarer diseases, the use of “omics” presents a step-forward that can be harnessed for more accurate ACVD prediction and risk assessment in larger populations. The analysis of these data by artificial intelligence (AI)/machine learning (ML) strategies makes is possible to decipher the large amount of data that derives from such techniques, in order to provide an unbiased assessment of pathophysiological correlations and to develop a better understanding of the molecular background of ACVD. The predictive models implementing data from these “omics”, are based on consolidated AI best practices for classical ML and deep learning paradigms that employ methods (e.g., Integrative Network Fusion method, using an AI/ML supervised strategy and cross-validation) to validate the reproducibility of the results. Here, we highlight the proposed integrated approach for the prediction and diagnosis of ACVD with the presentation of the key elements of a joint scientific project of the University of Milan and the Almazov National Medical Research Centre.

It is shown that NO2 present in air, beginning at a concentration of 1 ppm, can be selectively detected by sensors based on Au/WO3:Au thin films activated by laser diode radiation with maximum intensity at 400 nm instead of constant heating. The radiation-activated photodesorption reduces the time of sensor response to NO2. A high humidity of air under conditions of room-temperature irradiation additionally increases the device sensitivity to NO2 due to the appearance of additional adsorption sites. The absence of a sensor response to reducing gases and varying oxygen concentration in the atmosphere is caused by the photodesorption of chemisorbed $${\text{O}}_{2}^{ - }$$ species during their interaction with holes generated in intrinsic optical transitions in the near-surface region of WO3 film.

Квашнін В. О., Бабаш А. В., Яковлєв О. М. Визначення статичного моменту тертя при пресуванні зразка з одночасним крученням // Вісник ДДМА. – 2019. – № 2 (46). – C. 71–76. Наведено актуальність використання технології порошкової металургії для виробництва деталей. Описана технологія пресування під високим тиском з одночасним крученням зразка High Pressure Torsion. У статті наведений опис дослідницької установки для пресування зразків з одночасним крученням. Дослідницька установка включає прес зусиллям 10 т. Для контролю швидкості був використаний інкрементальний енкодер Siemens 6FX2001-2DB02. Для призведення механізму кручення в рух був використаний асинхронний двигун, який був під’єднаний до частотного перетворювача Altivar 31. Для зниження кількості обертів та підвищення крутного моменту був використаний редуктор 2Ч-80. При пресуванні з одночасним крученням зразка виникає сила тертя. Вона являє собою силу та момент статичного опору механізму кручення. Аналітичне визначення сили та моменту статичного опору механізму було представлено у статті. На основі даних сили та моменту статичного опору механізму був розрахований статичний момент навантаження асинхронного електродвигуна при максимальній силі пресування 10 т. Також наведено перевірочний розрахунок асинхронного двигуна на здатність витримати статичне навантаження. Перевірочний розрахунок показав, що наявний асинхронний електродвигун експериментальної установки здатен витримати статичне навантаження у вигляді моменту тертя при пресуванні зразка з одночасним його крученням. Всі розрахунки сили та моменту тертя при пресуванні з одночасним крученням здійснювалися для порошку титану, який є основним матеріалом при виробництві різних деталей медичного та іншого призначення.

The geometric structure, PES, and conformational dynamics of a 2,2-dimethylpropanal molecule in the lowest excited singlet and triplet electronic states are studied using the multiconfigurational CASPT2/def2-TZVPP approach. The problem of large-amplitude nuclear motions (the rotation of the tert-butyl group and the inversion of the nonplanar carbonyl moiety) is solved for each electronic state by variational means. It is shown that electronic excitation to both states causes the pyramidalization of the ССHO carbonyl moiety and rotation of the tert-butyl group. Results confirm the qualitative conclusions of an earlier analysis of the S1 ← S0 vibronic spectrum of a 2,2-dimethylpropanal molecule.

Scientific-methodical approaches to a study of nonlinear physicochemical processes are considered and an experimental setup intended for investigation of nonlinear physical and chemical processes accompanying irradiation of solids of various classes (including energetic materials) by UV, visible, and IR laser radiation is described. The possibility of synchronous multi-parameter measurements of the amplitude, spectral, kinetic, and spatial characteristics of the near-surface and bulk luminous laser plasma, solid-phase luminescence, acoustic pulses formed in the bulk of the samples, and morphology of residual damages has been demonstrated with a nanosecond time resolution. The energy density on the irradiated target surfaces varied from fractions of mJ/cm2 to 104 J/cm2 depending on the problem to be solved. The spectral range recorded for one irradiation pulse was 200–1100 nm, the spectral resolution was ~1.5 nm, and the spatial resolution was ~10 μm. A pressure pulse formed in the sample volume was recorded by an acoustic sensor with sensitivity of 0.15 V/bar and temporal resolution of ~5 ns.

Today there is a large number of vibration-proof materials for the manufacture of shock absorbers in the market of structural materials. For a reasonable choice, it is necessary to perform comparative tests of different elastomers according to several criteria. The paper presents the results of two-parameters comparative tests of three brands of polyurethane elastomers. As the evaluation criteria, the internal friction module and the loss tangent of elastomeric materials under alternating bending with rotation are chosen. High stability of physicomechanical properties of polyurethane elastomers is studied in the entire frequency range of mechanical vibrations.

Experimental apparatus is developed for investigating the influence of cuff heating in frictional contact with a rotating shaft. Empirical formulas for the temperature of rubber and polyurethane sealing cuffs as a function of the slip velocity and the excess pressure of the lubricant are determined.

This work is devoted to the currently relevant issues - optimization of warehousing. Cargo receiving and dispatch processes held in a medium-sized warehouse are being considered in this work in detail. Based on the results of preliminary analysis, several indicators were selected, necessary for the usage of intellectual analysis tools in order to predict the required number of employees at the warehouse entrances. In accordance with the purpose set, models for predicting the required number of employees at the entrances were created to ensure the working process in a way, which corresponds to the optimal value of the indicator “workload of the entrance”. Various methods of machine learning, such as decision tree, k-nearest neighbors regression, random forest, and feedforward neural network are considered in the context of the problem, mentioned above. Each of the models was trained with different values of the model's hyperparameters, which were selected in both manual heuristic-based mode and using specialized software tools for grid search (GridSearchCV) from the scikit-learn library, designed to find the optimal values of the hyperparameters. Using the automated search for hyperparameters when training models yields to a smaller mean-square error in comparison with manual selection of hyperparameters. According to the analysis results of the model prediction quality, it was found that the predicted number of employees closely corresponds to the real situation in comparison with the planned values being used by the company. Based on the obtained results, several recommendations were made to assess the growth of the economic efficiency of the enterprise.

For elucidation of the mechanisms of IgG binding with human plasminogen in prostate cancer patients, we propose an original ELISA on polystyrene plates with immobilized heavy and light plasminogen chains. The level of IgG bound to plasminogen heavy chain in the serum of prostate cancer patients significantly exceeded that in healthy volunteers. IgG treated with plasmin more actively (by more than 2 times) bound plasminogen heavy chain than intact IgG. These findings indicate the involvement of lysine-binding sites of plasminogen heavy chain in the interaction with the C-terminal lysine of IgG and their fragments. ROC analysis of ELISA data showed significant differences between serum samples from patients with prostate cancer and benign prostatic hyperplasia. It is hypothesized that IgG in the tumor region undergo proteolysis and their products appear in the circulation.

(Lu1-xMnx)3Al2(Al1-xSix)3O12: Ce3+ solid solution phosphors were synthesized via introducing the isostructural Mn3Al2(SiO4)3 (MAS) into Lu3Al5O12: Ce3+ (LuAG). Moreover, (Lu1-xMnx)3Al2(Al1-xSix)3O12: Ce3+ (x = 0–0.2) exhibits substantial spectra broadening (83→115 nm) due to the 5d→4f transition of Ce3+ and the 4T1→6A1 transition of Mn2+, respectively. The efficiency of energy transfer (ηT, Ce3+→Mn2+) gradually increases with the rising Mn2+ content, and the value reach approximately 45% at x = 0.2. Namely, the different characteristics of luminescence evolution based on effect of structural variation substituting (MnSi)6+ pair for the larger (LuAl)6+ pair. Therefore, with the structural evolution, the luminescence of the solid solution phosphors could be tuned from green to orange-red tunable by increasing the content of MAS for the applications of general lighting.

This article provides a detailed description of an experimental device to study the problems of wear of lip seals in frictional contact with a rotary shaft. The empirical dependences are presented for assessment of the magnitude of the wear of rubber and polyurethane lip seals depending on their lifetime.

This paper represents the research results of echocardiographic study for early prediction of mortality. The classification task is solved by analyzing the echocardiographic data from medical information system. Echocardiographic data of 90000 hearts condition extracted directly from medical information system were analyzed. The considered echocardiographic studies were conducted for patients with CHF, CHD, hypertension, heart arrhythmia, valvular heart disease, autoimmune disease, congenital heart defect, cardiomyopathy, endocrine disease, heart failure, mixed connective tissue disease, cancer, aneurism. Using machine learning methods and neural networks it is possible to make an early prediction of mortality based on instrumental echocardiographic study. It can be offered to clinicians as support for accurate, reasonable saving clinical decisions with minimization risks for patient’s health. The classification task mortality prediction is solved by machine learning methods with 97% ROC curve. The simple echocardiographic test results like FV Simpson, systolic volume, the valves condition, the condition of the ascending aorta and other echocardiographic data are used as predictors. Such a simple approach to solving critical tasks can make the method widely used in clinical practice.

The procedure is developed for modification of diamond surface by luminophore-containing organic compositions. The compositions are composed of an organic luminophore—scintillation anthracene, inorganic luminophore K-35 and cetane. Indication compositions are synthesized based on the selected luminophores and organic liquids and tested using pilot separator POLYUS-M. Spectral-kinetic characteristic of luminophopre-containing organic-mineral compositions, treated weakly luminous diamond crystals and kimberlite minerals are determined. The compositions ensuring better spectral-kinetic characteristics and higher extraction of diamonds during H-ray luminescence separation are selected.

In this article we presented the results of the study of hip joint mobility among 1-4 year students of Derzhavin Tambov State University engaged in health aerobics and its various types. The level of development of mobility in female students' hip joints to a large extent determines the effectiveness of training in the equipment of elements in classes of health aerobics, containing a significant number of movements performed by lower limbs (grazing, wavy, squat, etc.). Hip joint refers to spherical joints and therefore allows: bending and unbending; assignment and reduction; pronation and supination; roundabout. In everyday life, the maximum degree of motor load on the hip joint occurs during walking. However, the amplitude of hip movements used in walking does not reach a potential value, and the execution of circular and lateral movements is minimized. This circumstance at classes of health aerobics with female students is clearly demonstrated by the constriction of movements and lack of proper amplitude when performing motor actions with lower limbs. The mobility of female students' hip joint was assessed by the test «Cross split». The average group values obtained by the «Cross split» test served as the basis for the development of a scale for assessing the level of mobility in hip joints.

The effect of the complex enzyme preparation Bruzaym BGX on the viscosity of rye kneading was studied. The dynamics of glucose accumulation in the wort is shown, as well as the possibility of reducing the dosage of glucoamylase when using a multi-enzyme complex at the stage of water-heat treatment. The effect of the enzyme complex on the fermentation kinetics of rye wort was studied. It was found that the use of a multienzyme complex at the stage of water-heat treatment allows one to increase the glucose content in the wort by 34.7 %, compared with the control. This increases the yield of alcohol by 1.4 decalitres/t of conditional starch, reduces the duration of fermentation to 50 – 52 hours and reduces the total content of impurities in the mature brew by 10%.

We have obtained and analyzed the S1 ← S0 fluorescence excitation spectrum of jet-cooled 2-methylpropanal ((CH3)2CHCHO). In addition, the ab initio calculations of the 2-methylpropanal structure in the ground (S0) and lowest excited singlet (S1) electronic states have been carried out by the CASPT2/def2-TZVPP method. The calculations have shown that the S1 ← S0 electronic excitation of the 2-methylpropanal conformers (cis and gauche) causes large conformational changes: the isopropyl group rotates around the central C–C bond and the carbonyl fragment CCHO becomes non-planar. The potential energy surface of 2-methylpropanal in the S1 state has the six minima, corresponding to three pairs of mirror symmetry conformers: 1ab, 2ab, and 3ab. In the S1 ← S0 jet-cooled spectra of (CH3)2CHCHO and (CH3)2CHCDO three systems of vibronic transitions from the gauche (S0) conformer to vibrational levels of the 1, 2, and 3 conformers (S1) with the origins ( $$ {0}_0^0 $$ ) at 29,887; 30,198; and 29,963 cm−1 for (CH3)2CHCHO and 29,926; 30,221; and 29,990 cm−1 for (CH3)2CHCDO have been identified. The high activity of torsional and inversional vibrations of the 1, 2, and 3 conformers has been found for both molecules. Intensities of bands in torsional sequences pass through a maximum; it confirms the theoretical prediction about the minima shifts between the gauche and 1, 2, and 3 conformers along the torsional coordinate. Using the experimental inversional energy levels, the 1↔3 and 2a↔2b potential functions of inversion have been determined for both molecules. The corresponding calculated and experimental data are in satisfactory agreement.

Endorsed by: Research and Practical Council of the Ministry of Health of the Russian Federation.

High-temperature β-Ga2O3:Cr2O3-based sensors sensitive to oxygen- and hydrogen-containing gases have been developed and studied. Magnetron cosputtering is the method of choice for the thin film synthesis as an industry-compatible technique. The composition-structure-properties relationship has been revealed. An introduction of 0.04–0.14 wt. % Cr leads to a significant increase in the response of the O2 sensors over the temperature range 250–400 °C. The highest response in the above-mentioned temperature range has been achieved for a Cr addition of 0.14 wt. %. An increase in the Cr content from 0.04 to 0.22 wt. % leads to a decrease in the β-Ga2O3-based sensors’ response time, especially for low O2 concentrations (≤10 vol. %). Reliable control of the β-Ga2O3:Cr2O3-based sensors’ selectivity to industry-relevant reducing gases—hydrogen, carbon monoxide, and toluene—is demonstrated. β-Ga2O3 films with a Cr incorporation content of 0.04 and 0.06 wt. % have a high response to toluene at operating temperatures 300–500 °C, while the films with 0.14 and 0.22 wt. % Cr have a high response to H2 in the range 400–500 °C. Regardless of the Cr content in β-Ga2O3 thin films, all sensors considered demonstrate a weak response to CO within the operating temperature range 250–500 °C. The results attained are of certain technological importance, i.e., in terms of the development of cost-effective methods for the synthesis of materials and systems for monitoring and control of industry-relevant gases for an environmentally friendly and sustainable growth.

The paper studies the threshold, spectral, and kinetic characteristics of the luminescence of compacted samples from inert and energetic materials induced by their irradiation with the first harmonic of a neodymium laser (1064 nm, $\tau=16$ ns). The results establish that irradiation of pure (without specially introduced impurities) samples with laser radiation with an energy density of (0.5–3) J/cm2 forms so-called hot spots on their surface, the characteristics of which are determined by absorbing inhomogeneities (already present or introduced during sample preparation) and parameters of laser radiation. The atomic lines of alkali metals–Na and K–are predominant in the emission spectra. Multi-pulse excitation leads to annealing of absorbing inhomogeneities and increased optical breakdown threshold. In the samples with specially introduced aluminum impurities (composites), the luminescence and destruction thresholds are an order of magnitude smaller; the spatial distribution over the irradiated surface is close to homogeneous, and there are Al atomic lines in the luminescence spectra. The results obtained are interpreted via the concept of low-threshold optical breakdown, which develops on absorbing optical inhomogeneities and leads to the formation of near-surface laser plasma.

The autographic method was used to study the morphology of the damage occurring on the surface of metals and in polymethylmethacrylate (PMMA) after a single exposure to an electron beam formed in the vacuum diode of a pulsed electron accelerator in the modes of filamentation and self-focusing. It was found that in the zones of interaction between the filamentous beam and PMMA at a depth of $40-80\ \mu\mathrm{m}$ , micro-fractures of a round and more complex shape with a diameter of $10-50\ \mu\mathrm{m}$ form. The mechanism of local microdestruction formation is analyzed.

Tuning crystal phase transformations is very important for obtaining polymorphs for phosphors with the ideal optical properties and stability. Mn

Healthcare systems are challenged to deliver high-quality and efficient care. Studying patient flow in a hospital is particularly fundamental as it demonstrates effectiveness and efficiency of a hospital. Since hospital is a collection of physically nearby services under one administration, its performance and outcome are shaped by the interaction of its discrete components. Coordination of processes at different levels of organizational structure of a hospital can be studied using network analysis. Hence, this article presents a data-driven static and temporal network of departments. Both networks are directed and weighted and constructed using seven years’ (2010–2016) empirical data of 24902 Acute Coronary Syndrome (ACS) patients. The ties reflect an episode-based transfer of ACS patients from department to department in a hospital. The weight represents the number of patients transferred among departments. As a result, the underlying structure of network of departments that deliver healthcare for ACS patients is described, the main departments and their role in the diagnosis and treatment process of ACS patients are identified, the role of departments over seven years is analyzed and communities of departments are discovered. The results of this study may help hospital administration to effectively organize and manage the coordination of departments based on their significance, strategic positioning and role in the diagnosis and treatment process which, in-turn, nurtures value-based and precision healthcare.

The mode of continuous detonation combustion of hydrogen in the annular combustor of a model of a detonation air-breathing ramjet at the approach air stream Mach number 5.7 and a stagnation temperature of 1500 K was experimentally detected for the first time in a pulsed wind tunnel. The thrust and fuelbased specific impulse of the ramjet model were 1550 N and 3300 s, respectively.

The physical nature of emissions excited in pressed-sugar samples by the first harmonic of a neodymium laser (1064 nm, 12 ns) is studied. The spectral, kinetic, spatial, and amplitude characteristics of emissions upon single- and multipulse irradiation with energy densities of 0.012–3.2 J/cm2 are measured. It is found that excitation of a sample by the first pulse causes two emission types, namely, emission of the second harmonic of a Nd laser (532 nm) and glowing of dense low-temperature plasma formed as a result of a low-temperature optical breakdown on absorbing inhomogeneities. Multipulse excitation leads to annealing of absorbing inhomogeneities and to an increase in the optical breakdown threshold.

Organic and inorganic luminophores of similar luminescence parameters as diamonds are selected. Indicators, based on the selected luminophores, are synthesized. Spectral and kinetic characteristics of luminophores are experimentally determined for making a decision on optimal compositions to ensure maximum extraction of diamonds in X-ray luminescence separation owing to extra recovery of non-luminescent diamond crystals. As the components of luminophore-bearing indicators, anthracene and K-35 luminophores are selected as their parameters conform luminescence parameters of diamonds detected using X-ray luminescence separator with standard settings.

The mode of continuous spinning detonation (CSD) combustion of hydrogen in the annular combustor of a model of a hydrogen-fueled detonation ramjet under conditions of approach air stream Mach number 5.7 and stagnation temperature 1500 K is registered experimentally in a short-duration (pulsed) wind tunnel at the overall air-to-hydrogen equivalence ratio (ER) ranging from 0.7 to 1.4. The maximum values of thrust and specific impulse of the ramjet model are attained at ER = 1.25 and are estimated as 1550 N and 3300 s, respectively. At 1.4

A method of ELISA for measuring the binding of different samples of immunoglobulin (IgG) and its fragments to human plasminogen (Pg) has been developed. Instead of plasminogen, the heavy chain of plasminogen (Pg-H) containing five ligand-binding kringle domains, immobilized on the surface of the plate, was used in this method as a detector. It was found that IgG treated with plasmin (IgGPm-t) binds to the immobilized Pg-H 2.84 times more strongly than intact IgG. Both IgG samples showed a weak nonspecific binding to the immobilized light chain of plasminogen (Pg-L). It was shown that 0.2 M L-lysine inhibits the binding of IgGPm-t and does not affect the nonspecific binding of intact IgG to the immobilized Pg-H, indicating the involvement of lysine-binding regions of Pg-H in binding to IgGPm-t. A preliminary treatment of IgG samples with carboxypeptidase В (CPB) inhibited the binding of IgGPm-t and did not affect the nonspecific binding of intact IgG to the immobilized Pg-H, which indicates a key role of the С-terminal lysine of IgGPm-t in the specific binding to the lysine-binding sites of Pg. The study of the effects of intact IgG and IgGPm-t on the rate of activation of Glu- and Lys-forms of Pg (Glu-Pg and Lys-Pg) by a tissue activator of Pg (tPA) and urokinase (uPA) in buffer showed that intact IgG completely inhibited the activation of Glu-Pg and Lys-Pg with both tPA and uPA. Presumably, the inhibitory effect of intact IgG is due to steric hindrances that it creates for protein–protein interactions of the activators with the zymogen. IgGPm-t accelerated the generation of plasmin from Pg. In this case, the stimulatory effect of IgGPm-t on the activation of Glu-Pg under the action of tPA was ∼25% higher than on the activation of Lys-Pg, which is explained by more significant conformational changes in the Glu-Pg molecule compared with the Lys-Pg molecule after their binding to IgGPm-t. The results suggest that the specific cleavage of IgG by plasmin may be one of the ways by which the plasminogen/plasmin system is involved in various physiological and pathological processes.

In a demonstrator of a detonation rocket engine (DRE) using the natural gas–oxygen propellant system, a high (270 s) specific impulse at sea level at a low (32 atm) mean combustor pressure was experimentally obtained for the first time. Comparison of these characteristics with the respective ones (263 s and 61 atm) of the well-known Russian RD 170-A liquid-propellant rocket engine using deflagration combustion of the kerosene–oxygen propellant system showed that the specific impulse at sea level in the DRE is close to that in the deflagration-combustion engine but is produced at half as high a mean combustor pressure. This indicates that the energy efficiency of detonation combustion exceeds that of deflagration combustion, and that there is room to improve the weight–size characteristics of the turbopump unit in the DRE.

This paper presents ongoing research aimed at developing a data-driven platform for clinical decision support systems (DSSs) that require integration and processing of various data sources within a single solution. Resource management is developed within a framework of an urgent computing approach to address changing requirements defined by the incoming flow of patients with urgent diseases. This work presents DSS for support of ambulance and emergency medical service management for patients with acute coronary syndrome (ACS) as a working example with integration distributed streaming data sources as well as data storages (containing electrocardiography (ECG) data, electronic medical records (EMR), real-time monitoring of medical facilities, and schedules of hospitals within a network). This DSS has been developed in collaboration with the Federal Almazov North-West Medical Research Centre in Saint Petersburg.

(Tb1−xMnx)3Al2(Al1−xSix)3O12:Ce3+ solid solution phosphors were synthesized by introducing the isostructural Mn3Al2(SiO4)3 (MAS) into Tb3Al5O12:Ce3+ (TbAG). Under 456 nm excitation, (Tb1−xMnx)3Al2(Al1−xSix)3O12:Ce3+ shows energy transfers (ET) in the host, which can be obtained from the red emission components to enhance color rendering. Moreover, (Tb1−xMnx)3Al2(Al1−xSix)3O12:Ce3+ (x = 0–0.2) exhibits substantial spectral broadening (68 → 86 nm) due to the 5d → 4f transition of Ce3+ and the 4T1 → 6A1 transition of Mn2+. The efficiency of energy transfer (ηT, Ce3+ → Mn2+) gradually increases with increasing Mn2+ content, and the value reach approximately 32% at x = 0.2. Namely, the different characteristics of luminescence evolution based on the effect of structural variation by substituting the (MnSi)6+ pair for the larger (TbAl)6+ pair. Therefore, with structural evolution, the luminescence of the solid solution phosphors could be tuned from yellow to orange-red, tunable by increasing the content of MAS for the applications of white light emitting diodes (wLED).

This paper represents the research results of applying machine learning methods for early predicting of cardiovascular patients mortality. The classification task is solved by analyzing the dynamics data from electronic health records of the patients with the acute coronary syndrome, infarction, and stable angina. Moreover, the approach for identification of model components and their connection is developed. The model structure identification assimilates the patient condition, treatment phases in treatment dynamic. It provides the prediction of better model structure on following steps and request for necessary data to improve the forecast for more informed decision-making. The dynamic data extracted directly from medical information system were analyzed, that is very close to the real process. Using machine learning methods it is possible to make an early prediction of mortality risks. The prediction of laboratory results allows saving the resources. Jointly, both can be offered to clinicians as support for accurate, reasonable saving clinical decisions with minimization risks for patient’s health. The simple lab test results like hemoglobin (HGB), red blood cells (RBC), alanine transaminase (ALT), aspartate transaminase (AST), glucose, platelet (PLT), creatinine levels are used as a predictor. Such a simple approach to solving critical tasks can make the method widely used in clinical practice. The identification of the patient groups’ individuality into account the dynamics probably can contribute to E-science.