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Byline: Saman. Fatima, Ajay. Garg, Leve. Joseph, M. Padma Srivastava, Deepti. Vibha, Raghav. Bansal, Ashish. Bindra, Manjari. Tripathi, Rajesh. Singh, Arunmozhimaran. Elavarasi Carotid artery stenting (CAS) is performed in patients [...]

Byline: Kanchana. Pillai, Deepti. Vibha, Pranjal. Gupta, Pachipala. Sudheer, Biswamohan. Mishra, Rahul. Oinam, Ayush. Mohan, Kamalesh. Tayade, Padma. Srivastava, Manjari. Tripathi, Achal. Srivastava, Rohit. Bhatia, Roopa. Rajan, Awadh. Pandit, Rajesh. [...]

Introduction: Tubercular meningitis (TBM) is a common cause of chronic meningitis in India; however, there is a paucity of literature on optimum duration and choice of drug therapy. Materials and Methods: This was an ambispective cohort study. Results: Two hundred and forty-four patients of central nervous system tuberculosis (CNS TB) who were seronegative for HIV were studied of whom 198 had TBM and 46 patients had tuberculoma without meningitis. Before completion of treatment, 84% of TBM patients underwent imaging. There was no difference in disability or mortality in patients, who were treated with various drug regimens in terms of duration of therapy or number of drugs at initiation of treatment. However when patients developed new complications, adding more drugs improved survival. Prolonging corticosteroid administration in patients with nonsatisfactory improvement at 8 weeks was not associated with prevention of disability. Conclusions: CNS TB is treated by neurologists and physicians in India, as per their experience due to different recommendations in various guidelines. There is a tendency to decide when to stop treatment based on neuroimaging given the fear of poor outcomes associated with recurrence of the disease. The duration of treatment or choice of drugs at the start of treatment did not affect disability.

Normal-sized ventricles and absence of papilledema do not rule out shunt failure and raised intracranial pressure (ICP). Raised ICP can present with false localizing signs which may be cranial nerve palsies or extensive polyradiculopathy. Our patient with a history of ventriculoperitoneal (VP) shunt presented with rapidly progressive vision loss without papilledema, as well as multiple cranial nerve palsies and radiculopathy. Imaging did not reveal hydrocephalus, however, cerebrospinal fluid (CSF) manometry revealed high CSF opening pressure. After lumbar thecoperitoneal shunting, vision did not improve, but the rest of cranial nerve palsies and radiculopathy improved. In a patient in whom VP shunt is in situ, headache and vomiting should prompt evaluation for raised ICP though there is no ventriculomegaly of papilledema. Vision can be saved if raised ICP is suspected, CSF opening pressure measured at presentation and prompt surgery is performed.

Byline: Pranjal. Gupta, Biswamohan. Misra, Pachipala. Sudheer, Rohit. Bhatia, Mamta. Singh, M. P. Srivastava, Manjari. Tripathi, Achal. Srivastava, Kameshwar. Prasad, Deepti. Vibha, V. Vishnu, Awadh. Pandit, Rajesh. Singh, Anu. Gupta, [...]

Byline: Arunmozhimaran. Elavarasi, Kameshwar. Prasad Population-based studies are essential to determine the incidence, prevalence, etiologies, management trends, and prognosis of any disease in the population. Robust data on these epidemiologic [...]

Green-synthesized nitrogen-doped carbon quantum dots (N-CQDs), offering an excellent platform for the ultra-sensitive dual detection of tannic acid and Hg2+ ions, were explored in this work. The N-CQDs were synthesized in a straightforward, cost-effective, and environmentally friendly hydrothermal method. These N-CQDs exhibited remarkable and dynamic "on-off-on" luminescent characteristics, demonstrating an exceptional sensitivity and selectivity towards tannic acid and Hg2+ ions. The specific interactions between the N-CQDs and tannic acid, along with the reversible binding with Hg2+ ions, contribute to the distinct dual-detection capabilities. The sensing system covers a linear concentration range of 10–80 µM to tannic acid and 0.1 to 1 nm for Hg2+, showcasing its versatility for different concentration range with a lower detection limit of 25 nM and 3 nM, respectively. Furthermore, the N-CQDs displayed high stability and minimal interference from typical interfering species, making them a desirable tool for environmental monitoring and quality control. Validation through real sample analysis substantiates the accuracy and reliability of the developed sensing approach in practical scenarios. This study not only underscores the promise of green-synthesized N-CQDs as enhanced fluorescence probes but also contributes to the development of efficient and environmentally friendly materials for dual sensing applications. [ABSTRACT FROM AUTHOR]

Despite broad evidence in the past demonstrating the relationships between personality traits and organizational citizenship behavior, research on organizational citizenship behavior from the perspective of emotional contagion has not received deserving attention to date. Drawing on the trait theory and affective event theory as an overarching reference, this study theorizes emotional contagion as a moderator by arguing that it improves the above relationship incrementally. This study conducted hierarchical multiple regression analysis to test the hypotheses and adopted the Johnson–Neyman method using SPSS PROCESS Macro to probe the pattern of the significant interactions. A total of 320 bank employees took part in the survey. The findings revealed, agreeableness and conscientiousness as significant predictors of organizational citizenship behavior. Furthermore, the above association was enhanced for employees at the conditional level of high emotional contagion. The study provides insight into recognizing the significance of employees' emotional levels and their contribution to organizational growth. [ABSTRACT FROM AUTHOR]

Byline: Rohit. Bhatia, M. Padma Srivastava, P. Sylaja, Snigdha. Komakula, Ashish. Upadhyay, Vibhor. Pardasani, Thomas. Iype, Rajsrinivas. Parthasarathy, Rajshekhar. Reddy, Suman. Kushwaha, Jayanta. Roy, P. Satish, Anjan. Trikha, Naveet. Wig, [...]

Introduction: Meralgia paresthetica (MP) is a painful mononeuropathy of the lateral femoral cutaneous nerve. It is usually idiopathic and can be treated with drugs used for neuropathic pain such as pregabalin, gabapentin, and amitriptyline. Objectives: This study was done to study the effect of triamcinolone acetonide on drug refractory MP. Methods: This study was a retrospective case file review. Results: Eight patients were treated with local injections of triamcinolone. The patients were followed up for a period of 4 months to 54 months. There was significant symptomatic improvement with six patients having complete improvement and all patients reporting >50% improvement. Patients who had recurrence of symptoms on follow up received up to four injections as per their requirement and repeated injections also produced >50% symptom relief. Conclusion: Triamcinolone acetonide injected locally seems to be an effective and safe treatment for refractory MP. A randomized control trial has been planned to look for efficacy and safety.