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104. Thalamic but Not Subthalamic Neuromodulation Simplifies Word Use in Spontaneous Language

Author

Hannes Ole Tiedt, Felicitas Ehlen, Michelle Wyrobnik, and Fabian Klostermann

Subjects
thalamus, language, deep brain stimulation, lexical frequency, frequency effect, lexical access, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Several investigations have shown language impairments following electrode implantation surgery for Deep Brain Stimulation (DBS) in movement disorders. The impact of the actual stimulation, however, differs between DBS targets with further deterioration in formal language tests induced by thalamic DBS in contrast to subtle improvement observed in subthalamic DBS. Here, we studied speech samples from interviews with participants treated with DBS of the thalamic ventral intermediate nucleus (VIM) for essential tremor (ET), or the subthalamic nucleus (STN) for Parkinson’s disease (PD), and healthy volunteers (each n = 13). We analyzed word frequency and the use of open and closed class words. Active DBS increased word frequency in case of VIM, but not STN stimulation. Further, relative to controls, both DBS groups produced fewer open class words. Whereas VIM DBS further decreased the proportion of open class words, it was increased by STN DBS. Thus, VIM DBS favors the use of relatively common words in spontaneous language, compatible with the idea of lexical simplification under thalamic stimulation. The absence or even partial reversal of these effects in patients receiving STN DBS is of interest with respect to biolinguistic concepts suggesting dichotomous thalamic vs. basal ganglia roles in language processing.

Published
2021
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106. The Co-Creation-Wheel: A Four-Dimensional Model of Collaborative Interorganistional Innovation

Author

Ehlen, Corry, van der Klink, Marcel, Stoffers, Jol, and Boshuizen, Henny

Abstract

Purpose: This study aims to design and validate a conceptual and practical model of co-creation. Co-creation, to design collaborative new products, services and processes in contact with users, has become more and more important because organisations increasingly require multidisciplinary collaboration inside and outside the organisation to respond to challenges and create added value. Design/methodology/approach: This is a design and validation study, which uses mixed-methods, a reconstructive design and a semi-structured interview with a questionnaire as validation. The designed model is validated by 14 scholars and practitioners across fields. Findings:Designed is a conceptual and practical model, the four-dimensional Co-Creation-Wheel, which contains success factors for co-creation: 12 internal team factors plus 4 external conditions and a core. The validation study of this model, scientifically and as a practical instrument, supported the importance of the components of the model and suggested slight improvements. This resulted in a refinement of the first designed Co-Creation-Wheel. Research limitations/implications: Although restricted usefulness to large-scale structured innovation practices was expected, the instrument has a broader reach. First applications demonstrate that this Co-Creation-Wheel is multifunctional and international. It inspires, supports reflection of collaboration, stimulates interventions to enhance co-creation practices and human resource development (HRD) activities and is able to measure the quality of co-creation elements. Further research on its effects in co-creation practices is necessary, especially on the role of HRD in co-creation. Originality/value: This study is the first to design and validate a multifaceted, holistic conceptual and practical model of co-creation that is easy to use for innovators in practice and is multifunctional.

Published
2017
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108. Autonomic Dysfunction Impairs Baroreflex Function in an Alzheimer’s Disease Animal Model

Author

Ehlen, John C., Forman, Cassadi M., Ostrowski, Daniela, and Ostrowski, Tim D.

Subjects
Psychiatry and Mental health, Clinical Psychology, General Neuroscience, General Medicine, Geriatrics and Gerontology, Article
Abstract

Background: Alzheimer’s disease (AD) patients frequently present with orthostatic hypotension. This inability to reflexively increase blood pressure on standing is a serious health concern and increases the risk of stroke and cardiovascular diseases. Objective: Since there are no clear mechanisms for orthostatic hypotension in human AD, the present study assessed the autonomic changes that could explain this comorbidity in an AD animal model. Methods: We used the established streptozotocin-induced rat model of AD (STZ-AD), which mimics many hallmark symptoms of sporadic AD in humans. Baroreflex responses were analyzed in anesthetized STZ-AD rats using femoral catheterization for blood pressure and heart rate, and autonomic activity was assessed using specific blockers and splanchnic sympathetic nerve recordings. Expression levels of autonomic receptors at the heart were examined using the western blot technique. Results: Baroreflex function in STZ-AD showed a blunted heart rate (HR) response to low blood pressure challenges, and the maximal sympathetic nerve activity was reduced. Conversely, HR responses to high blood pressure were similar to control, indicating no change in parasympathetic nerve activity. Under resting conditions, autonomic blockade demonstrated a baseline shift to increased sympathetic tone in STZ-AD. Protein expression levels of beta-1 adrenergic receptor and muscarinic acetylcholine receptor M2 in the heart were unchanged. Conclusion: Our study provides the first data on the pathological influence of AD on baroreflex function, which primarily affected the sympathetic nervous system in STZ-AD. These results represent the first mechanisms that may correlate with the orthostatic hypotension in human AD.

Published
2022

109. A Vector Space Model for Neural Network Functions: Inspirations From Similarities Between the Theory of Connectivity and the Logarithmic Time Course of Word Production

Author

Ortwin Fromm, Fabian Klostermann, and Felicitas Ehlen

Subjects
neural network, connectivity, word production, vector space, energy efficiency, neural clique, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

The present report examines the coinciding results of two study groups each presenting a power-of-two function to describe network structures underlying perceptual processes in one case and word production during verbal fluency tasks in the other. The former is theorized as neural cliques organized according to the function N = 2i − 1, whereas the latter assumes word conglomerations thinkable as tuples following the function N = 2i. Both theories assume the innate optimization of energy efficiency to cause the specific connectivity structure. The vast resemblance between both formulae motivated the development of a common formulation. This was obtained by using a vector space model, in which the configuration of neural cliques or connected words is represented by a N-dimensional state vector. A further analysis of the model showed that the entire time course of word production could be derived using basically one single minimal transformation-matrix. This again seems in line with the principle of maximum energy efficiency.

Published
2020
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110. Mindfulness-Based Interventions for In-Patients With Schizophrenia Spectrum Disorders—A Qualitative Approach

Author

Kerem Böge, Almira Karadza, Lukas M. Fuchs, Felicitas Ehlen, Thi Minh Tam Ta, Neil Thomas, Malek Bajbouj, and Eric Hahn

Subjects
mindfulness, schizophrenia spectrum disorders, in-patient, qualitative research, positive symptoms, negative symptoms, Psychiatry, RC435-571
Abstract

In recent years, mindfulness-based interventions (MBI) have gained clinical relevance in the treatment of patients with schizophrenia spectrum disorders (SSDs). High symptom burden, long durations of hospitalization and high rehospitalization rates demonstrate the severity and cost-intensity of these disorders. MBIs have shown promising treatment outcomes in a small number of trials, primarily taking place in English-speaking countries. The current study aims to explore mechanisms and processes as well as adverse effects of MBIs on in-patients with SSDs in a German university hospital setting. A qualitative design based on inductive thematic analysis accompanied by quantitative assessments was chosen. A semi-structured interview guide was developed by psychiatrists and psychologists to assess patient experiences, perceptions, thoughts, and feelings during and after taking part in a MBI. Twenty-seven interviews were conducted between September 2017 and October 2018 with in-patients who are diagnosed with schizophrenia or schizoaffective disorder. Rater-based questionnaires, such as the Positive and Negative Syndrome Scale (PANSS), Montgomery Asberg Depression Rating Scale (MADRS), and Psychotic Symptom Rating Scales-Auditory Hallucination (PSYRATS-AH) were administered at baseline to collect clinical outcomes. Qualitative analysis revealed two domains: content and function. In the first domain related to content with the core elements “detachment and rumination”, “presence and getting lost”, “non-judgment and judgment”, and effects with “emotions”, “cognition”, and “symptom changes”. A second domain related to function was extracted, including the relevance of perception of context and transfer to everyday life. Overall, improvements concerning cognition, distress, and psychopathology were detected, while no adverse effects, such as increased psychotic symptoms, were revealed. As the first study of its kind, mechanisms, processes, and the safety of MBIs were explored and confirmed in a sample of German in-patients with SSDs. The results of this qualitative study are in line with recent findings on MBIs amongst patients with psychotic disorders from other countries. Results lay the ground for future research to focus on the systematic study of MBIs in large samples, its treatment processes, outcomes, and effectiveness for in-patients with SSDs.

Published
2020
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111. Impact of deep brain stimulation of the subthalamic nucleus on natural language in patients with Parkinson's disease.

Author

Felicitas Ehlen, Bassam Al-Fatly, Andrea A Kühn, and Fabian Klostermann

Subjects
Medicine, Science
Abstract

BackgroundIn addition to the typical motor symptoms, a majority of patients suffering from Parkinson's disease experience language impairments. Deep Brain Stimulation of the subthalamic nucleus robustly reduces motor dysfunction, but its impact on language skills remains ambiguous.MethodTo elucidate the impact of subthalamic deep brain stimulation on natural language production, we systematically analyzed language samples from fourteen individuals (three female / eleven male, average age 66.43 ± 7.53 years) with Parkinson's disease in the active (ON) versus inactive (OFF) stimulation condition. Significant ON-OFF differences were considered as stimulation effects. To localize their neuroanatomical origin within the subthalamic nucleus, they were correlated with the volume of tissue activated by therapeutic stimulation.ResultsWord and clause production speed increased significantly under active stimulation. These enhancements correlated with the volume of tissue activated within the associative part of the subthalamic nucleus, but not with that within the dorsolateral motor part, which again correlated with motor improvement. Language error rates were lower in the ON vs. OFF condition, but did not correlate with electrode localization. No significant changes in further semantic or syntactic language features were detected in the current study.ConclusionThe findings point towards a facilitation of executive language functions occurring rather independently from motor improvement. Given the presumed origin of this stimulation effect within the associative part of the subthalamic nucleus, this could be due to co-stimulation of the prefrontal-subthalamic circuit.

Published
2020
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112. RESPONDENT MODE CHOICE IN A SMARTPHONE SURVEY

Author

CONRAD, FREDERICK G., SCHOBER, MICHAEL F., ANTOUN, CHRISTOPHER, YAN, H. YANNA, HUPP, ANDREW L., JOHNSTON, MICHAEL, EHLEN, PATRICK, VICKERS, LUCAS, and ZHANG, CHAN

Published
2017

115. cCPE Fusion Proteins as Molecular Probes to Detect Claudins and Tight Junction Dysregulation in Gastrointestinal Cell Lines, Tissue Explants and Patient-Derived Organoids

Author

Waldow, Ayk, primary, Beier, Laura-Sophie, additional, Arndt, Janine, additional, Schallenberg, Simon, additional, Vollbrecht, Claudia, additional, Bischoff, Philip, additional, Farrera-Sal, Martí, additional, Loch, Florian N., additional, Bojarski, Christian, additional, Schumann, Michael, additional, Winkler, Lars, additional, Kamphues, Carsten, additional, Ehlen, Lukas, additional, and Piontek, Jörg, additional

Published
2023
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117. Hippo Signaling Modulates the Inflammatory Response of Chondrocytes to Mechanical Compressive Loading

Author

Cai, Xiaomin, primary, Warburton, Christopher, additional, Perez, Olivia F., additional, Wang, Ying, additional, Ho, Lucy, additional, Finelli, Christina, additional, Ehlen, Quinn T., additional, Wu, Chenzhou, additional, Rodriguez, Carlos D., additional, Kaplan, Lee, additional, Best, Thomas M., additional, Huang, Chun-Yuh, additional, and Meng, Zhipeng, additional

Published
2023
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126. Unravelling the Social Dynamics of an Industry-School Partnership: Social Capital as Perspective for Co-Creation

Author

Ehlen, Corry G. J. M., van der Klink, Marcel R., and Boshuizen, Henny P. A.

Abstract

Increasingly, innovative collaboration between industry and schools is being exploited as a way of improving the quality and relevance of education. Even though these innovations appear to have substantial benefits, often the impact proves to fade away after their implementation. A better understanding of how to sustain complex innovations seems important. Unfortunately, only a limited amount of research investigates the "inside" of complex innovations. This article reports on a three-year, large-scale industry-school programme in the Dutch Leisure sector. The research, from start to finish, adopted a qualitative case study methodology with a mixed-methods approach, drawing upon social capital theory as lens to understand the dynamics of processes and effect on outcomes. Findings indicate that the social capital theory helps to unravel crucial factors of processes and outcomes. The researched innovation process depended not so much on formal project plans and objectives but largely built on the quality of social relationships at all levels. Sustaining this social capital proved crucial, while managing according to a planned change strategy appeared to be counterproductive. The outcomes show to be twofold, in terms of new knowledge and products for the organisations and of sustainable benefits for the professionals, in terms of new abilities.

Published
2016
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127. Meaning of Food

Author

Wolf, Lea, Ruiner, Caroline, and Ehlen, Ronny

Subjects
Wertzuschreibung, Plattformen, Bedeutung, Bedeutungskonstruktion, Lebensmittel
Abstract

Der etablierte Lebensmittelhandel zeichnet sich durch spezifische Praktiken der Selektion und Allokation von Lebensmitteln entlang etablierter, aber streitbarer Kriterien der Wertzuschreibung aus. Digitale Plattformen bieten neue Möglichkeiten die Kritik an den Formen der Wertzuschreibung zu formulieren, alternative Bedeutungskonstruktionen von Lebensmitteln zu präsentieren und in alltagsweltliche Alternativpraktiken zu überführen. Ziel dieses Beitrags ist, die Bedeutungskonstruktion von Lebensmitteln durch Plattformen zu untersuchen. Die Analyse basiert auf vier Fallbeispielen, die entweder an den Folgen der Lebensmittelallokation ansetzen oder sich als Alternative zum regulären Lebensmittelhandel positionieren. Die Ergebnisse zur Bedeutungskonstruktion von Lebensmitteln zeigen, wie Plattformen ausgehend von der durch sie adressierten Kritik nicht nur die Vermittlung von Angebot und Nachfrage initiieren, sondern diese auch rahmen und mit Bedeutung versehen. Überdies verweisen sie auf die Komplementarität technologischer und aufklärerischer Ansätze zur Lösung nicht-nachhaltigen Handelns im Umgang mit Lebensmitteln. There are several systematic inefficiencies in the allocation and selection of goods along well-established but contested criteria of how value is created. Digital platforms offer new possibilities to express criticism about these inefficiencies and to alter the attribution and construction of meaning. Furthermore, they have the potential to translate them into everyday practices. The aim of this article is to investigate how the meaning of food is constructed by platforms. The analysis is based on four case studies, which either start at the consequences of food distribution or position themselves as an alternative to common food retailers. The results on the construction of meaning of food show how platforms not only initiate the mediation of supply and demand, but also frame it and construct meaning. Furthermore, they point to the complementarity of technological and educational approaches to solve unsustainable behaviour in relation to food. (peer reviewed), Soziologie und Nachhaltigkeit, Bd. 9 Nr. 1 (2023): Nachhaltigkeit und Digitalisierung

Published
2023
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140. Immediate Postoperative Care

Author

Messing-Jünger, Martina, Ehlen, Michael, Schindler, Ehrenfried, Özek, M. Memet, editor, Cinalli, Giuseppe, editor, Maixner, Wirginia, editor, and Sainte-Rose, Christian, editor

Published
2015
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144. Resuscitation of Term Compromised and Asphyctic Newborns: Better with Intact Umbilical Cord?

Author

Friederike Ott, Angela Kribs, Patrick Stelzl, Ioannis Kyvernitakis, Michael Ehlen, Susanne Schmidtke, Tamina Rawnaq-Möllers, Werner Rath, Richard Berger, and Holger Maul

Subjects
Maternity and Midwifery, Obstetrics and Gynecology
Abstract

The authors hypothesize that particularly severely compromised and asphyctic term infants in need of resuscitation may benefit from delayed umbilical cord clamping (after several minutes). Although evidence is sparse, the underlying pathophysiological mechanisms support this assumption. For this review the authors have analyzed the available research. Based on these data they conclude that it may be unfavorable to immediately clamp the cord of asphyctic newborns (e.g., after shoulder dystocia) although recommended in current guidelines to provide quick neonatological support. Compression of the umbilical cord or thorax obstructs venous flow to the fetus more than arterial flow to the placenta. The fetus is consequently cut off from a supply of oxygenated, venous blood. This may cause not only hypoxemia and consecutive hypoxia during delivery but possibly also hypovolemia. Immediate cord clamping may aggravate the situation of the already compromised newborn, particularly if the cord is cut before the lungs are ventilated. By contrast, delayed cord clamping leads to fetoplacental transfusion of oxygenated venous blood, which may buffer an existing acidosis. Furthermore, it may enhance blood volume by up to 20%, leading to higher levels of various blood components, such as red and white blood cells, thrombocytes, mesenchymal stem cells, immunoglobulins, and iron. In addition, the resulting increase in pulmonary perfusion may compensate for an existing hypoxemia or hypoxia. Early cord clamping before lung perfusion reduces the preload of the left ventricle and hinders the establishment of sufficient circulation. Animal models and clinical trials support this opinion. The authors raise the question whether it would be better to resuscitate compromised newborns with intact umbilical cords. Obstetric and neonatal teams need to work even closer together to improve neonatal outcomes.

Published
2022

145. Supplementary Tables and References from BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

Author

Shimelis, Hermela, primary, Mesman, Romy L.S., primary, Von Nicolai, Catharina, primary, Ehlen, Asa, primary, Guidugli, Lucia, primary, Martin, Charlotte, primary, Calléja, Fabienne M.G.R., primary, Meeks, Huong, primary, Hallberg, Emily, primary, Hinton, Jamie, primary, Lilyquist, Jenna, primary, Hu, Chunling, primary, Aalfs, Cora M., primary, Aittomäki, Kristiina, primary, Andrulis, Irene, primary, Anton-Culver, Hoda, primary, Arndt, Volker, primary, Beckmann, Matthias W., primary, Benitez, Javier, primary, Bogdanova, Natalia V., primary, Bojesen, Stig E., primary, Bolla, Manjeet K., primary, Borresen-Dale, Anne-Lise, primary, Brauch, Hiltrud, primary, Brennan, Paul, primary, Brenner, Hermann, primary, Broeks, Annegien, primary, Brouwers, Barbara, primary, Brüning, Thomas, primary, Burwinkel, Barbara, primary, Chang-Claude, Jenny, primary, Chenevix-Trench, Georgia, primary, Cheng, Ching-Yu, primary, Choi, Ji-Yeob, primary, Collée, J. Margriet, primary, Cox, Angela, primary, Cross, Simon S., primary, Czene, Kamila, primary, Darabi, Hatef, primary, Dennis, Joe, primary, Dörk, Thilo, primary, dos-Santos-Silva, Isabel, primary, Dunning, Alison M., primary, Fasching, Peter A., primary, Figueroa, Jonine, primary, Flyger, Henrik, primary, García-Closas, Montserrat, primary, Giles, Graham G., primary, Glendon, Gord, primary, Guénel, Pascal, primary, Haiman, Christopher A., primary, Hall, Per, primary, Hamann, Ute, primary, Hartman, Mikael, primary, Hogervorst, Frans B., primary, Hollestelle, Antoinette, primary, Hopper, John L., primary, Ito, Hidemi, primary, Jakubowska, Anna, primary, Kang, Daehee, primary, Kosma, Veli-Matti, primary, Kristensen, Vessela, primary, Lai, Kah-Nyin, primary, Lambrechts, Diether, primary, Marchand, Loic Le, primary, Li, Jingmei, primary, Lindblom, Annika, primary, Lophatananon, Artitaya, primary, Lubinski, Jan, primary, Machackova, Eva, primary, Mannermaa, Arto, primary, Margolin, Sara, primary, Marme, Frederik, primary, Matsuo, Keitaro, primary, Miao, Hui, primary, Michailidou, Kyriaki, primary, Milne, Roger L., primary, Muir, Kenneth, primary, Neuhausen, Susan L., primary, Nevanlinna, Heli, primary, Olson, Janet E., primary, Olswold, Curtis, primary, Oosterwijk, Jan J.C., primary, Osorio, Ana, primary, Peterlongo, Paolo, primary, Peto, Julian, primary, Pharoah, Paul D.P., primary, Pylkäs, Katri, primary, Radice, Paolo, primary, Rashid, Muhammad Usman, primary, Rhenius, Valerie, primary, Rudolph, Anja, primary, Sangrajrang, Suleeporn, primary, Sawyer, Elinor J., primary, Schmidt, Marjanka K., primary, Schoemaker, Minouk J., primary, Seynaeve, Caroline, primary, Shah, Mitul, primary, Shen, Chen-Yang, primary, Shrubsole, Martha, primary, Shu, Xiao-Ou, primary, Slager, Susan, primary, Southey, Melissa C., primary, Stram, Daniel O., primary, Swerdlow, Anthony, primary, Teo, Soo H., primary, Tomlinson, Ian, primary, Torres, Diana, primary, Truong, Thérèse, primary, van Asperen, Christi J., primary, van der Kolk, Lizet E., primary, Wang, Qin, primary, Winqvist, Robert, primary, Wu, Anna H., primary, Yu, Jyh-Cherng, primary, Zheng, Wei, primary, Zheng, Ying, primary, Leary, Jennifer, primary, Walker, Logan, primary, Foretova, Lenka, primary, Fostira, Florentia, primary, Claes, Kathleen B.M., primary, Varesco, Liliana, primary, Moghadasi, Setareh, primary, Easton, Douglas F., primary, Spurdle, Amanda, primary, Devilee, Peter, primary, Vrieling, Harry, primary, Monteiro, Alvaro N.A., primary, Goldgar, David E., primary, Carreira, Aura, primary, Vreeswijk, Maaike P.G., primary, and Couch, Fergus J., primary

Published
2023
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146. Data from BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

Author

Shimelis, Hermela, primary, Mesman, Romy L.S., primary, Von Nicolai, Catharina, primary, Ehlen, Asa, primary, Guidugli, Lucia, primary, Martin, Charlotte, primary, Calléja, Fabienne M.G.R., primary, Meeks, Huong, primary, Hallberg, Emily, primary, Hinton, Jamie, primary, Lilyquist, Jenna, primary, Hu, Chunling, primary, Aalfs, Cora M., primary, Aittomäki, Kristiina, primary, Andrulis, Irene, primary, Anton-Culver, Hoda, primary, Arndt, Volker, primary, Beckmann, Matthias W., primary, Benitez, Javier, primary, Bogdanova, Natalia V., primary, Bojesen, Stig E., primary, Bolla, Manjeet K., primary, Borresen-Dale, Anne-Lise, primary, Brauch, Hiltrud, primary, Brennan, Paul, primary, Brenner, Hermann, primary, Broeks, Annegien, primary, Brouwers, Barbara, primary, Brüning, Thomas, primary, Burwinkel, Barbara, primary, Chang-Claude, Jenny, primary, Chenevix-Trench, Georgia, primary, Cheng, Ching-Yu, primary, Choi, Ji-Yeob, primary, Collée, J. Margriet, primary, Cox, Angela, primary, Cross, Simon S., primary, Czene, Kamila, primary, Darabi, Hatef, primary, Dennis, Joe, primary, Dörk, Thilo, primary, dos-Santos-Silva, Isabel, primary, Dunning, Alison M., primary, Fasching, Peter A., primary, Figueroa, Jonine, primary, Flyger, Henrik, primary, García-Closas, Montserrat, primary, Giles, Graham G., primary, Glendon, Gord, primary, Guénel, Pascal, primary, Haiman, Christopher A., primary, Hall, Per, primary, Hamann, Ute, primary, Hartman, Mikael, primary, Hogervorst, Frans B., primary, Hollestelle, Antoinette, primary, Hopper, John L., primary, Ito, Hidemi, primary, Jakubowska, Anna, primary, Kang, Daehee, primary, Kosma, Veli-Matti, primary, Kristensen, Vessela, primary, Lai, Kah-Nyin, primary, Lambrechts, Diether, primary, Marchand, Loic Le, primary, Li, Jingmei, primary, Lindblom, Annika, primary, Lophatananon, Artitaya, primary, Lubinski, Jan, primary, Machackova, Eva, primary, Mannermaa, Arto, primary, Margolin, Sara, primary, Marme, Frederik, primary, Matsuo, Keitaro, primary, Miao, Hui, primary, Michailidou, Kyriaki, primary, Milne, Roger L., primary, Muir, Kenneth, primary, Neuhausen, Susan L., primary, Nevanlinna, Heli, primary, Olson, Janet E., primary, Olswold, Curtis, primary, Oosterwijk, Jan J.C., primary, Osorio, Ana, primary, Peterlongo, Paolo, primary, Peto, Julian, primary, Pharoah, Paul D.P., primary, Pylkäs, Katri, primary, Radice, Paolo, primary, Rashid, Muhammad Usman, primary, Rhenius, Valerie, primary, Rudolph, Anja, primary, Sangrajrang, Suleeporn, primary, Sawyer, Elinor J., primary, Schmidt, Marjanka K., primary, Schoemaker, Minouk J., primary, Seynaeve, Caroline, primary, Shah, Mitul, primary, Shen, Chen-Yang, primary, Shrubsole, Martha, primary, Shu, Xiao-Ou, primary, Slager, Susan, primary, Southey, Melissa C., primary, Stram, Daniel O., primary, Swerdlow, Anthony, primary, Teo, Soo H., primary, Tomlinson, Ian, primary, Torres, Diana, primary, Truong, Thérèse, primary, van Asperen, Christi J., primary, van der Kolk, Lizet E., primary, Wang, Qin, primary, Winqvist, Robert, primary, Wu, Anna H., primary, Yu, Jyh-Cherng, primary, Zheng, Wei, primary, Zheng, Ying, primary, Leary, Jennifer, primary, Walker, Logan, primary, Foretova, Lenka, primary, Fostira, Florentia, primary, Claes, Kathleen B.M., primary, Varesco, Liliana, primary, Moghadasi, Setareh, primary, Easton, Douglas F., primary, Spurdle, Amanda, primary, Devilee, Peter, primary, Vrieling, Harry, primary, Monteiro, Alvaro N.A., primary, Goldgar, David E., primary, Carreira, Aura, primary, Vreeswijk, Maaike P.G., primary, and Couch, Fergus J., primary

Published
2023
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147. Supplementary Figures from BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

Author

Shimelis, Hermela, primary, Mesman, Romy L.S., primary, Von Nicolai, Catharina, primary, Ehlen, Asa, primary, Guidugli, Lucia, primary, Martin, Charlotte, primary, Calléja, Fabienne M.G.R., primary, Meeks, Huong, primary, Hallberg, Emily, primary, Hinton, Jamie, primary, Lilyquist, Jenna, primary, Hu, Chunling, primary, Aalfs, Cora M., primary, Aittomäki, Kristiina, primary, Andrulis, Irene, primary, Anton-Culver, Hoda, primary, Arndt, Volker, primary, Beckmann, Matthias W., primary, Benitez, Javier, primary, Bogdanova, Natalia V., primary, Bojesen, Stig E., primary, Bolla, Manjeet K., primary, Borresen-Dale, Anne-Lise, primary, Brauch, Hiltrud, primary, Brennan, Paul, primary, Brenner, Hermann, primary, Broeks, Annegien, primary, Brouwers, Barbara, primary, Brüning, Thomas, primary, Burwinkel, Barbara, primary, Chang-Claude, Jenny, primary, Chenevix-Trench, Georgia, primary, Cheng, Ching-Yu, primary, Choi, Ji-Yeob, primary, Collée, J. Margriet, primary, Cox, Angela, primary, Cross, Simon S., primary, Czene, Kamila, primary, Darabi, Hatef, primary, Dennis, Joe, primary, Dörk, Thilo, primary, dos-Santos-Silva, Isabel, primary, Dunning, Alison M., primary, Fasching, Peter A., primary, Figueroa, Jonine, primary, Flyger, Henrik, primary, García-Closas, Montserrat, primary, Giles, Graham G., primary, Glendon, Gord, primary, Guénel, Pascal, primary, Haiman, Christopher A., primary, Hall, Per, primary, Hamann, Ute, primary, Hartman, Mikael, primary, Hogervorst, Frans B., primary, Hollestelle, Antoinette, primary, Hopper, John L., primary, Ito, Hidemi, primary, Jakubowska, Anna, primary, Kang, Daehee, primary, Kosma, Veli-Matti, primary, Kristensen, Vessela, primary, Lai, Kah-Nyin, primary, Lambrechts, Diether, primary, Marchand, Loic Le, primary, Li, Jingmei, primary, Lindblom, Annika, primary, Lophatananon, Artitaya, primary, Lubinski, Jan, primary, Machackova, Eva, primary, Mannermaa, Arto, primary, Margolin, Sara, primary, Marme, Frederik, primary, Matsuo, Keitaro, primary, Miao, Hui, primary, Michailidou, Kyriaki, primary, Milne, Roger L., primary, Muir, Kenneth, primary, Neuhausen, Susan L., primary, Nevanlinna, Heli, primary, Olson, Janet E., primary, Olswold, Curtis, primary, Oosterwijk, Jan J.C., primary, Osorio, Ana, primary, Peterlongo, Paolo, primary, Peto, Julian, primary, Pharoah, Paul D.P., primary, Pylkäs, Katri, primary, Radice, Paolo, primary, Rashid, Muhammad Usman, primary, Rhenius, Valerie, primary, Rudolph, Anja, primary, Sangrajrang, Suleeporn, primary, Sawyer, Elinor J., primary, Schmidt, Marjanka K., primary, Schoemaker, Minouk J., primary, Seynaeve, Caroline, primary, Shah, Mitul, primary, Shen, Chen-Yang, primary, Shrubsole, Martha, primary, Shu, Xiao-Ou, primary, Slager, Susan, primary, Southey, Melissa C., primary, Stram, Daniel O., primary, Swerdlow, Anthony, primary, Teo, Soo H., primary, Tomlinson, Ian, primary, Torres, Diana, primary, Truong, Thérèse, primary, van Asperen, Christi J., primary, van der Kolk, Lizet E., primary, Wang, Qin, primary, Winqvist, Robert, primary, Wu, Anna H., primary, Yu, Jyh-Cherng, primary, Zheng, Wei, primary, Zheng, Ying, primary, Leary, Jennifer, primary, Walker, Logan, primary, Foretova, Lenka, primary, Fostira, Florentia, primary, Claes, Kathleen B.M., primary, Varesco, Liliana, primary, Moghadasi, Setareh, primary, Easton, Douglas F., primary, Spurdle, Amanda, primary, Devilee, Peter, primary, Vrieling, Harry, primary, Monteiro, Alvaro N.A., primary, Goldgar, David E., primary, Carreira, Aura, primary, Vreeswijk, Maaike P.G., primary, and Couch, Fergus J., primary

Published
2023
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