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Effect of taurine o binding of 45Ca2+ and 8-aniline-I-naphthaline culfonate by microsomes of rat brain cells was studied. Increased accumulation of Ca2+ in phospholipids of microsomes as well as a distinct decrease in the number of sites for binding of 8-aniline-I-naphthaline sulfonate were observed in presence of taurine. Activity of Ca2+-ATPase was simultaneously increased. The data obtained suggest that the effect of taurine on biomembranes is related to local alterations in their surface charge.

Electrophoresis in the polyacrylamide gel and ultracentrifugation with a multistage density gradient demonstrated virtually the whole of the blood plasma lipoproteids spectrum to be contained in the human aortal wall. An immunological identity of the whole beta- and alpha-lipoproteids and also of their individual apoproteins in the aortal wall and blood plasma was ascertained. Moreover, the ratio of etherified cholesterol/total cholesterol in the vascular and plasmatic lipoproteids proved to be quiet close. In determining the content of the summary pre-beta-and beta-lipoproteids in the aortal wall the quantity of the said lipoproteids in atherosclerotic lesions was found several times as high as in a normal aorta, whereas the lipoproteids concentration in an intact aortal wall correlated with the intensity of atherosclerosis in the same aorta. The data obtained bear evidence to a plasmatic origin of lipoproteids in the vascular wall and to their important role in atherogenesis.

An immune complex of lipoprotein-antibody was found in human blood plasma and in tissue liquid of aorta, impaired by atherosclerosis. In the majority of cases the antigen component of the immune complex was lipoprotein of very low density. After dissociation of the complex at acid pH, immunoglobulin G was isolated, which was identified by double immunodiffusion in agar gel; the immunoglobulin reacted in RBS both with autological and, in some cases, with isological lipoproteins.

Purified C-reactive protein induces the production of autoantibodies to lipoprotein B-containing lipoproteins in animals. This is due to a C-reactive protein idiotype that permits the, interference of C-reactive protein in the idiotype-anti-idiotypical immunological reactions and stimulation of autoimmune response to lipoproteins.