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Objective To understand the geographic differences of bone mineral density(BMD) in women and the effect of using a multi-center combined reference database for diagnosing osteoporosis. Methods The reference population comprised 10 343 females, aged 20-89 years old, from Changsha, Beijing, Nanjing, Shanghai, Jiaxing, Guangzhou, and Chengdu. Except for Changsha(n=1 157), data were obtained from the GE Health Care service. Lumbar spine and femoral neck BMD was measured in the subjects using a bone densitometer(GE-Lunar DXA series). Results Data were analyzed using eight different regression models. We found that the cubic regression model was the best for describing age-related changes in BMD. The coefficients of determination(R2) of the fitting curve were 0.149 to 0.546(all P=0.000). For the best-fit curve of lumbar spine BMD with age, the minimal difference was between Beijing and Nanjing(3.0%±3.4%), and the maximal difference was between Beijing and Chengdu(12.9%±4.9%). The differences in curve values for femoral neck BMD were relatively small between regions. Compared with the multi-center combined BMD database, the detection rate for lumbar spine osteoporosis was higher by using the Beijing database(17.5% vs. 12.2%, P=0.028), and the rates were lower by using the Jiaxing(23.9% vs. 30.3%, P=0.001), Changsha(30.4% vs. 35.9%, P=0.037) and Chengdu databases(34.8% vs. 41.0%, P=0.032). Conclusion There are geographic differences in female BMD in mainland China, especially for lumbar spine BMD, so multiple regional BMD reference databases should be established in China. [ABSTRACT FROM AUTHOR]

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Both bone morphogenetic protein-2 and platelet-rich plasma can promote bone healing. However, little is reported on application of bone morphogenetic protein-2 or platelet-rich plasma to induced membrane technique in basic research and clinical studies. OBJECTIVE: To investigate the clinical efficacy of bone grafting with recombinant human bone morphogenetic protein-2 or autologous platelet-rich plasma versus simple bone grafting in the repair of bone defects during a phase II surgery using induced membrane technique. METHODS: 59 patients with bone defects who received treatment in the First Affiliated Hospital of Guangzhou University of Chinese Medicine during January 2013-January 2018 were included in this study. Following phase I surgery with induced membrane technique, these patients were assigned to receive phase II surgery: autologous bone grafting with recombinant human bone morphogenetic protein-2 (group A, n=20), autologous bone grafting with autologous platelet-rich plasma (group B, n=21), autologous bone grafting (group C, n=18). Postoperative complications (recurrent infection, joint stiffness, muscle atrophy, persistent pain, etc.) were recorded. Bone healing time and osteophyte score were evaluated by X-rays. This study was approved by the Ethics Committee of the First Affiliated Hospital of Guangzhou University of Chinese Medicine, China. RESULTS AND CONCLUSION: (1) All 59 patients were followed up for 11-40 months. (2) The average bone healing time was (29.30±4.54), (28.71±5.37), and (35.50±7.37) weeks in the groups A, B and C, respectively. The average bone time in the groups A and B was significantly shorter than that in the group C (P < 0.05). (3) At 6 months after surgery, the osteophyte scores in the groups A and B were significantly higher than those in the group C (9.50±1.43, 9.14±0.85, 7.83±1.42, P < 0.05). (4) There were two cases of deep infection and one case of bone resorption in the group A. There was one case of deep infection and one case of residual knee stiffness with moderate pain in the group B. There were four cases of infection, three cases of bone resorption, delayed healing and one case of residual knee stiffness and muscle atrophy in the group C. The number of complications in the groups A and B was significantly less than that in the group C (P < 0.05). (5) The results suggest that application of bone morphogenetic protein-2 or autologous platelet-rich plasma to phase II induced membrane technique for repair of bone defects can accelerate bone healing and obtain encouraging repair efficacy with a few postoperative complications. [ABSTRACT FROM AUTHOR]

目的探讨强骨胶囊辅助诱导膜技术治疗感染性骨髓炎并骨缺损的临床效果。方法选择感染性骨髓 炎并骨缺损患者45例，根据患者是否接受强骨胶囊辅助治疗，分为观察组24例、对照组21例。对照组仅采用诱导 膜技术治疗,观察组采用强骨胶囊辅助诱导膜技术治疗。记录两组骨缺损临床愈合时间，计算植骨1年骨缺损临 床愈合率。植骨6个月，评估植骨区骨痂Lane-sandhuX线评分和疼痛视觉模拟评分(VAS)。统计手术期间及植骨 6个月内并发症情况，如关节僵硬、肌肉萎缩、感染、下肢短缩等。结果观察组骨缺损临床愈合时间明显短于对照 组(P<0.05)，但两组植骨1年骨缺损临床愈合率比较P>0.05。观察组植骨6个月骨痂Lane-sandhu X线评分明 显高于对照组（P <0.05)，但两组VAS比较P >0.05。两组手术期间及植骨6个月内并发症发生率比较P >0.05。 结论强骨胶囊辅助诱导膜技术治疗感染性骨髓炎并骨缺损能够促进植骨生长，加快骨缺损临床愈合，使患肢早 期恢复功能，但并不影响最终骨缺损临床愈合效果。 [ABSTRACT FROM AUTHOR]

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the diagnostic value of elastic quantitative analysis combined with hard ring sign for differentiating benign and malignant thyroid nodules. Methods: The clinical data of 121 cases of patients with thyroid nodules confirmed by operation or biopsy in our hospital from January 2018 to September 2018 were retrospectively analyzed. All the patients underwent elastography quantitative analysis and shear wave elastography (SWE) analysis. Quantitative analysis of elastography, SWE analysis and combined detection were performed. The results were golden standard (78 benign and 43 malignant), sensitivity, specificity, accuracy, positive predictive value and negative predictive value for the diagnosis of benign and malignant thyroid nodules. Quantitative analysis of elastography, SWE and ROC curves were drawn respectively, and the areas under ROC curves were compared. Results: (1) Elastic quantitative analysis of 87 benign nodules, 34 malignant, the sensitivity was 73.08%, the specificity was 30.23%, the positive predictive value was 65.51%, the negative predictive value was 38.24%; (2) SWE analysis of 76 benign nodules, 45 malignant nodules, the sensitivity was 64.10%, the specificity was 39.53%, the positive predictive value was 65.79%, the negative predictive value was 37.78%; (3) 73 benign nodules, 48 malignant nodules, the sensitivity was 89.74%, the specificity was 93.02%, the positive predictive value was 95.89%, the negative predictive value was 83.33%; (4) The sensitivity, specificity, positive predictive value and negative predictive value of combined detection were higher than those of single detection (P<0.05); (5) Quantitative analysis of elastography. The area under ROC curve was 0.843, 0.819 and 0.940, respectively. The accuracy of combined detection was higher than that of single method (P<0.05). SWE analysis of the modulus of elasticity of benign and malignant thyroid nodules Emean, Emin, Emax, Esd, Emean-p and Emean-m were significantly larger than the malignant nodules (P<0.05). Conclusions: Quantitative analysis of elastography combined with hard ring sign detection can significantly improve the sensitivity and specificity in the diagnosis of benign and malignant thyroid nodules, and it has high clinical value. [ABSTRACT FROM AUTHOR]

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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Journal of Oral & Maxillofacial Surgery is the property of Shanghai Jiao Tong University, College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Clean Coal Technology is the property of Clean Coal Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Mitogen-activated protein kinases (MAPK) is a class of serine/threonine protein kinase. This cascade existed broadly in mammalian cells. The subfamily includes extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38MAPK. It is a significant signaling pathway to deliver extracellular signals into nucleus, involved in the important mechanisms of cell growth and proliferation. Recently studies found that function of p38MAPK, mediating many cell reactions induced by stress, inflammatory cytokines or bacterial products and changing the level of gene expression through phosphorylation of transcription factor and play an important role in cell functions, involved in the process of oophoroma cells apoptosis, invasion, metastasis and drug resistance. Therefore, the clarification of mechanism of p38MAPK pathway will provide new thoughts and methods for diagnosis and treatment of ovarian cancer. This review summarizes the function of p38MAPK signal transduction pathway in ovarian cancer, and the p38MAPK related research progress of new drugs and drug resistance. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Clean Coal Technology is the property of Clean Coal Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Harbin Institute of Technology. Social Sciences Edition / Haerbin Gongye Daxue Xuebao. Shehui Kexue Ban is the property of Harbin Institute of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oil Crop Sciences is the property of Oil Crops Research Institute of Chinese Academy of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate whether CNR2 gene, which has been shown to be related to osteoporosis in some populations,is associated with bone mineral density (BMD) or osteoporosis in Han Chinese postmenopausal women. Methods We examine 39 SNPs covering the region of CNR2 gene in 3121 Han Chinese postmenopausal women, consisting of 1032 osteoporosis patients and 2089 healthy controls, and evaluated their association with BMD and osteoporosis. Results We found that rs4237 and rs2501431 were significantly associated with BMD and osteoporosis (corrected P = 0. 020 and 0. 017) in our sample, and the TT genotype of rs2501431 and the AA genotype of rs4237 had lower lumbar spine and femoral neck BMD compared with other genotypes. Additionally, analyses by haplotypes indicated that two haplotype blocks, containing rs4237 and rs2501431 respectively, in the CNR2 gene significantly associated with BMD and osteoporosis (both global permutation P < 0. 001), and a risk haplotype (ATTT) in the block of rs3003336-rs2501431-rs2502992-rs2501432 had an almost 4-fold increase in the osteoporosis cases. Conclusion Our results provide further supportive evidence for an important role of CNR2 gene in the etiology of osteoporosis and suggest that it may be a genetic risk factor for BMD and osteoporosis in Han Chinese postmenopausal women. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Oil Crop Sciences is the property of Oil Crops Research Institute of Chinese Academy of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Clean Coal Technology is the property of Clean Coal Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Telecommunication Engineering is the property of Telecommunication Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)