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Self-related stimuli such as one's own face or name seem to be processed differently from non-self stimuli and to involve greater attentional resources, as indexed by larger amplitude of the P3 event-related potential (ERP) component. Nonetheless, the differential processing of self-related vs. non-self information using voice stimuli is still poorly understood. The present study investigated the electrophysiological correlates of processing self-generated vs. non-self voice stimuli, when they are in the focus of attention.ERP data were recorded from twenty right-handed healthy males during an oddball task comprising pre-recorded self-generated (SGV) and non-self (NSV) voice stimuli. Both voices were used as standard and deviant stimuli in distinct experimental blocks. SGV was found to elicit more negative N2 and more positive P3 in comparison with NSV. No association was found between ERP data and voice acoustic properties.These findings demonstrated an earlier and later attentional bias to self-generated relative to non-self voice stimuli. They suggest that one's own voice representation may have a greater affective salience than an unfamiliar voice, confirming the modulatory role of salience on P3. (C) 2015 Elsevier B.V. All rights reserved., This work was supported by Grants IF/00334/2012, PTDC/PSI-PCL/116626/2010 and PTDC/MHN-PCN/3606/2012 funded by Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) and FEDER (Fundo Europeu de Desenvolvimento Regional) through the European programs QREN (Quadro de Referencia Estrategico Nacional), and COMPETE (Programa Operacional Factores de Competitividade), awarded to A.P.P., and a by a FCT Doctoral Grant (SFRH/BD/77681/2011) awarded to T.C.

[Letter to the editor], There are only a few treatments available for Tourette syndrome (TS). These treatments frequently do notwork in patients with moderate to severe TS [1]. Neuroimaging studies show a correlation between tics severity and increased activation over motor pathways, along with reduced activation over the control areas of the cortico-striato-thalamo-cortical circuits [2]. Moreover, the temporal pattern of tic generation suggests that cortical activation especially in the SMA precedes subcortical activation [3]. Following this assumption, here we explored the brain effects of 10-daily sessions of cathodal transcranial Direct Current Stimulation (tDCS) delivered over the pre-SMA in a patient with refractory and severe TS and also assessed whether those changes were long lasting (up to 6 months)., Study funding: This work was supported by the Portuguese Foundation for Science and Technology (FCT) with two individual grants (SFRH/BPD/86041/2012 and SFRH/BPD/86027/2012).Disclosure: The authors report no disclosures relevant to the manuscript.

The aim of the present study is to explore obsessive-compulsive disorder (OCD)-related abnormalities in white matter connectivity in OCD for a core region associated with inhibitory control [i.e. inferior frontal gyrus (IFG)]. Fifteen patients with OCD (11 men) and 15 healthy controls (nine men) underwent diffusion tensor imaging scanning to study four diffusivity indexes of white matter integrity [fractional anisotropy, mean diffusivity (MD), axial diffusivity and radial diffusivity (RD)]. The results showed that persons with OCD manifested significantly lower fractional anisotropy levels in the bilateral IFG as well as its parcellations in the pars opercularis, pars triangularis, and pars orbitalis. Significantly higher levels of MD, RD were evident for the OCD group in the IFG as a whole as well as in the bilateral subregions of the pars triangularis and pars opercularis (for MD and RD), the right side of the pars orbitalis (for RD), and the left side of the pars triangularis and right side pars opercularis (for axial diffusivity). Overall, the results suggest significant alterations in structural connectivity, probably associated with myelination and axonal abnormalities in the IFG of OCD patients., This work was partially supported by a research award to the first author (O.F.G.) from the Brain Imaging Network Grid/FCT (Portugal). Jorge Leite (SFRH/BPD/86027/2012) and Sandra Carvalho (SFRH/BPD/86041/2012) are supported by grants from the Portuguese Foundation for Science and Technology (FCT) and European Union (FSE-POPH).

Recent studies have demonstrated the positive effects of musical training on the perception of vocally expressed emotion. This study investigated the effects of musical training on event-related potential (ERP) correlates of emotional prosody processing. Fourteen musicians and fourteen control subjects listened to 228 sentences with neutral semantic content, differing in prosody (one third with neutral, one third with happy and one third with angry intonation), with intelligible semantic content (semantic content condition--SCC) and unintelligible semantic content (pure prosody condition--PPC). Reduced P50 amplitude was found in musicians. A difference between SCC and PPC conditions was found in P50 and N100 amplitude in non-musicians only, and in P200 amplitude in musicians only. Furthermore, musicians were more accurate in recognizing angry prosody in PPC sentences. These findings suggest that auditory expertise characterizing extensive musical training may impact different stages of vocal emotional processing., This work was supported by Grants IF/00334/2012, PTDC/PSIPCL/ 116626/2010 and PTDC/MHN-PCN/3606/2012 funded by Fundação para a Ciência e a Tecnologia (FCT, Portugal) and FEDER (Fundo Europeu de Desenvolvimento Regional) through the European programs QREN (Quadro de Referência Estratégico Nacional), and COMPETE (Programa Operacional Factores de Competitividade), awarded to A.P.P.

Sensory cortices of individuals who are congenitally deprived of a sense can exhibit considerable plasticity and be recruited to process information from the senses that remain intact. Here, we explored whether the auditory cortex of congenitally deaf individuals represents visual field location of a stimulusa dimension that is represented in early visual areas. We used functional MRI to measure neural activity in auditory and visual cortices of congenitally deaf and hearing humans while they observed stimuli typically used for mapping visual field preferences in visual cortex. We found that the location of a visual stimulus can be successfully decoded from the patterns of neural activity in auditory cortex of congenitally deaf but not hearing individuals. This is particularly true for locations within the horizontal plane and within peripheral vision. These data show that the representations stored within neuroplastically changed auditory cortex can align with dimensions that are typically represented in visual cortex., J. Almeida was funded by European Commission Seventh Framework Programme 2007-2013 Grant No. PCOFUND-GA-2009-246542 and by Fundacao BIAL Grant 112/12. F. Fang was funded by National Natural Science Foundation of China (NSFC) Grants 30925014 and 31230029. B. Z. Mahon was supported by U.S. National Institutes of Health Grants R21NS076176 and R01NS089609. Y. Bi was funded by NSFC Grants 31171073 and 31222024. This research was supported by Fundacao BIAL., info:eu-repo/semantics/publishedVersion

The dorsolateral prefrontal cortex (DLPFC) is involved in the cognitive appraisal and modulation of the pain experience. In this sham-controlled study, with healthy volunteers, we used bi-hemispheric transcranial direct current stimulation (tDCS) over the DLPFC to assess emotional reactions elicited by pain observation. Left-cathodal/right-anodal tDCS decreased valence and arousal evaluations compared to other tDCS conditions. Compared to sham condition, both left-cathodal/right-anodal and left-anodal/right-cathodal tDCS decreased hostility, sadness and self-pain perception. These decreased sensations after both active tDCS suggest a common role for left and right DLPFC in personal distress modulation. However, the differences in arousal and valence evaluations point to distinct roles of lateralized DLPFC in cognitive empathy, probably through distinct emotion regulation mechanisms., This experiment was supported by the National Council for Scientific and Technological Development (CNPq-480891/2012-5). LMM is supported by a scientific initiation grant (CNPq – 160553/2013-0). OML is supported by a FAPESP PhD grant (FAPESP – 2012/24696-1). PSB is a CNPq research fellow (304164/2012-7).

This study used event-related potentials to examine interactions between mood, sentence context, and semantic memory structure in schizophrenia. Seventeen male chronic schizophrenia and 15 healthy control subjects read sentence pairs after positive, negative, or neutral mood induction. Sentences ended with expected words (EW), within-category violations (WCV), or between-category violations (BCV). Across all moods, patients showed sensitivity to context indexed by reduced N400 to EW relative to both WCV and BCV. However, they did not show sensitivity to the semantic memory structure. N400 abnormalities were particularly enhanced under a negative mood in schizophrenia. These findings suggest abnormal interactions between mood, context processing, and connections within semantic memory in schizophrenia, and a specific role of negative mood in modulating semantic processes in this disease.

There has been an increased interest in the study of language processes in psychotherapy. More recently, research and theoretical formulations of the therapeutic process suggested that we must move from the microscopic study of verbal modes to a macroscopic approach in which these modes are organized into narratives. Narratives are conceived, in this perspective, as the basic instruments for meaning making. In this article the research on narrative processes in psychotherapy is reviewed and discussed in terms of its implications for the theory and practice of cognitive narrative psychotherapy. Additionally some of the main data coming from research projects on cognitive narrative psychotherapy are presented.

Recent advances in the field of neuroscience have dramatically changed our understanding of brain– behavior relationships. In this article, we illustrate how neuroscience can provide a conceptual and methodological framework to understand our clients within a transdiagnostic developmental perspective. We provide directions for integrating neuroscience into future process and outcome research. We present examples on how neuroscience can be integrated into researching the effects of contextual counseling interventions. We posit that interpersonal and environmental factors, such as neurotoxic factors (e.g., emotional neglect, stress), positive neurodevelopmental factors (e.g., nurturing and caring, environmental enrichment), and therapeutic interventions influence psychological processes (executive control, behavioral flexibility, reinforcement learning and approach motivation, emotional expression and regulation, self-representation and theory of mind). These psychological processes influence brain networks (attention, motivational, emotional regulation, social cognition), which influence cognitive, social, emotional, identity, and vocational development.

Objectives: The therapeutic effects of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation in patients with major depression have shown promising results; however, there is a lack of mechanistic studies using biological markers (BMs) as an outcome. Therefore, our aim was to review noninvasive brain stimulation trials in depression using BMs. Methods: The following databases were used for our systematic review: MEDLINE, Web of Science, Cochrane, and SCIELO. We examined articles published before November 2012 that used TMS and transcranial direct current stimulation as an intervention for depression and had BM as an outcome measure. The search was limited to human studies written in English. Results: Of 1234 potential articles, 52 articles were included. Only studies using TMS were found. Biological markers included immune and endocrine serum markers, neuroimaging techniques, and electrophysiological outcomes. In 12 articles (21.4%), end point BM measurements were not significantly associated with clinical outcomes. All studies reached significant results in the main clinical rating scales. Biological marker outcomes were used as predictors of response, to understand mechanisms of TMS, and as a surrogate of safety. Conclusions: Functional magnetic resonance imaging, single-photon emission computed tomography, positron emission tomography, magnetic resonance spectroscopy, cortical excitability, and brain-derived neurotrophic factor consistently showed positive results. Brain-derived neurotrophic factor was the best predictor of patients’ likeliness to respond. These initial results are promising; however, all studies investigating BMs are small, used heterogeneous samples, and did not take into account confounders such as age, sex, or family history. Based on our findings, we recommend further studies to validate BMs in noninvasive brain stimulation trials in MDD., Dr Fregni is granted by The Christopher and Dana Reeve Foundation, The Ruth Judy Goldberg Foundation, The National Institutes of Health, and by the American Heart Association.

Individuals with Williams syndrome (WS) present a set of cognitive, affective and motor symptoms that resemble those of patients with lesions to the cerebellum. Although there is some evidence for overall structural alterations in this brain region in WS, explorations on cerebellar white matter and cerebellar cortex volumes remain rather neglected. We aimed to compare absolute and relative cerebellar volumes, as well as patterns of white matter to cortex volumes in this brain region, between a group of individuals with WS and a group of healthy controls. T1 -weighted magnetic resonance images were acquired in 17 individuals with WS and in 15 typically developing individuals. Our results showed that even though individuals from the clinical group had significantly smaller cerebrums (and cerebellums), cerebellar volumes relative to intracranial volumes were significantly enlarged. In addition, while gray matter was relatively spared and white matter disproportionately reduced in the cerebrum in WS, relative cerebellar cortex and white matter volumes were preserved. These findings support the hypothesis that volume alterations in the cerebellum are associated with the cognitive, affective and motor profiles in WS. (c) 2014 Elsevier Ltd. All rights reserved.

Background: Abnormalities in emotional prosody processing have been consistently reported in schizophrenia and are related to poor social outcomes. However, the role of stimulus complexity in abnormal emotional prosody processing is still unclear. Method: We recorded event-related potentials in 16 patients with chronic schizophrenia and 16 healthy controls to investigate: 1) the temporal course of emotional prosody processing; and 2) the relative contribution of prosodic and semantic cues in emotional prosody processing. Stimuli were prosodic single words presented in two conditions: with intelligible (semantic content condition—SCC) and unintelligible semantic content (pure prosody condition—PPC). Results: Relative to healthy controls, schizophrenia patients showed reduced P50 for happy PPC words, and reduced N100 for both neutral and emotional SCC words and for neutral PPC stimuli. Also, increased P200 was observed in schizophrenia for happy prosody in SCC only. Behavioral results revealed higher error rates in schizophrenia for angry prosody in SCC and for happy prosody in PPC. Conclusions: Together, these data further demonstrate the interactions between abnormal sensory processes and higher-order processes in bringing about emotional prosody processing dysfunction in schizophrenia. They further suggest that impaired emotional prosody processing is dependent on stimulus complexity., This work was supported by two grants awarded to A.P.P.: Post-Doctoral Grant no. SFRH/BD/35882/2007 funded by Fundacao para a Ciencia e a Tecnologia (FCT, Portugal); and research grant no. PTDC/PSI-PCL/116626/2010, funded by FCT and FEDER (Fundo Europeu de Desenvolvimento Regional) through the European programs QREN (Quadro de Referencia Estrategico Nacional) and COMPETE (Programa Operacional Factores de Competitividade). It was additionally supported by two grants from the National Institute of Mental Health (no. RO1 MH 040799 awarded to R.W.M. and no. RO3 MH 078036 awarded to M.A.N.).

Several studies have shown that basic emotions are responsible for a significant enhancement of early visual processes and increased activation in visual processing brain regions. It may be possible that the cognitive uncertainty and repeated behavioral checking evident in Obsessive Compulsive Disorder (OCD) is due to the existence of abnormalities in basic survival circuits, particularly those associated with the visual processing of the physical characteristics of emotional-laden stimuli. The objective of the present study was to test if patients with OCD show evidence of altered basic survival circuits, particularly those associated with the visual processing of the physical characteristics of emotional stimuli. Fifteen patients with OCD and 12 healthy controls underwent functional magnetic resonance imaging acquisition while being exposed to emotional pictures, with different levels of arousal, intended to trigger the defensive and appetitive basic survival circuits. Overall, the present results seem to indicate dissociation in the activity of the defense and appetitive survival systems in OCD. Results suggest that the clinical group reacts to basic threat with a strong activation of the defensive system mobilizing widespread brain networks (i.e., frontal, temporal, occipital-parietal, and subcortical nucleus) and blocking the activation of the appetitive system when facing positive emotional triggers from the initial stages of visual processing (i.e., superior occipital gyrus).

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, primarily characterized by motor symptoms such as tremor, rigidity, bradykinesia, stiffness, slowness and impaired equilibrium. Although the motor symptoms have been the focus in PD, slight cognitive deficits are commonly found in non-demented and non-depressed PD patients, even in early stages of the disease, which have been linked to the subsequent development of pathological dementia. Thus, strongly reducing the quality of life (QoL). Both levodopa therapy and deep brain stimulation (DBS) have yield controversial results concerning the cognitive symptoms amelioration in PD patients. That does not seems to be the case with transcranial direct current stimulation (tDCS), although better stimulation parameters are needed. Therefore we hypothesize that simultaneously delivering cathodal tDCS (or ctDCS), over the right prefrontal cortex delivered with anodal tDCS (or atDCS) to left prefrontal cortex could be potentially beneficial for PD patients, either by mechanisms of homeostatic plasticity and by increases in the extracellular dopamine levels over the striatum., This work was supported by the Portuguese Foundation for Science and Technology with individual Grants (SFRH/BPD/86027/ 2012) and (SFRH/BPD/86041/2012). The sponsors had no role in the establishment of the present hypothesis

O presente artigo procura ilustrar o modo como os desenvolvimentos das neurociências cognitivas poderão ajudar a compreender alguns dos processos psicológicos básicos e, simultaneamente, ser traduzidos para importantes domínios da psicologia aplicada, particularmente no domínio clínico. Exemplificaremos a partir de algumas linhas de investigação programática em curso nas diferentes subsecções do Laboratório de Neuropsicofisiologia da Escola de Psicologia da Universidade do Minho. As potencialidades metodológicas proporcionadas pela neurofisiologia, neuroimagiologia, neuromodelação, psicofisiologia, neurobioquímica e neurogenética serão exemplificadas nas suas aplicações à linguagem (e suas implicações para a compreensão da esquizofrenia), funcionamento sócio-cognitivo (e implicações para a compreensão das perturbações do neurodesenvolvimento), funcionamento executivo (com implicações para a compreensão das perturbações do espectro obsessivo), empatia (e implicações para a compreensão da psicoterapia), mecanismos de stress (com implicações para a compreensão das perturbações de ansiedade), e, finalmente, comportamento animal (com implicações para o conhecimento dos sistemas sensoriais e perceptuais)., (undefined)

Although some studies point to cognitive stimulation as a beneficial therapy for older adults with cognitive impairments, this area of research and practice is still lacking dissemination and is underrepresented in many countries. Moreover, the comparative effects of different intervention durations remain to be established and, besides cognitive effects, pragmatic parameters, such as cost-effectiveness and experiential relevance to participants, are seldom explored. In this work, we present a randomized con- trolled wait-list trial evaluating 2 different intervention durations (standard 1⁄4 17 vs brief 1⁄4 11 sessions) of a cognitive stimulation program developed for older adults with cognitive impairments with or without dementia. 20 participants were randomly assigned to the standard duration intervention program (17 sessions, 1.5 months) or to a wait-list group. At postintervention of the standard intervention group, the wait-list group crossed over to receive the brief intervention program (11 sessions, 1 month). Changes in neuropsychological, functionality, quality of life, and caregiver outcomes were evaluated. Experience during intervention and costs and feasibility were also evaluated. The current cognitive stimulation programs (ie, standard and brief) showed high values of experiential relevance for both intervention durations. High adherence, completion rates, and reasonable costs were found for both formats. Further studies are needed to definitively establish the potential efficacy, optimal duration, cost-effectiveness, and experiential relevance for participants of cognitive intervention approaches., The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by the Portuguese Foundation for Science and Technology, with individual grants (SFRH/BD/64457/2009 and SFRH/BD/65213/2009, co-funded by FSE/POPH) and project grant PIC/IC/83290/2007, supported by FEDER (POFC-COMPETE).

Methuselah (mth) is a chromosome 3 Drosophila mutant with an increased lifespan. A large number of studies have investigated the genetic, molecular, and biochemical mechanisms of the mth gene.Much less is known about the effects of mth on preservation of sensorimotor abilities throughout Drosophila’s lifespan, particularly in late life. The current study investigated functional senescence in mth and its parental-control line (w1118) in two experiments thatmeasured age-dependent changes in flight functions and locomotor activity. In experiment 1, a total of 158 flies (81 mth and 77 controls) with an age range from 10 to 70 days were individually tethered under an infrared laser-sensor system that allowed monitoring of flight duration during phototaxic flight. We found that mth has a statistically significant advantage in maintaining continuous flight over control flies at age 10 days, but not during middle and late life. At age 70 days, the trend reversed and parental control flies had a small but significant advantage, suggesting an interaction between age and genotype in the ability to sustain flight. In experiment 2, a total of 173 different flies (97 mth and 76 controls) with an age range from 50 to 76 days were individually placed in a large well-lit arena (60×45 cm) and their locomotor activity quantified as the distance walked in a 1-min period. Results showed that mth flies had lower levels of locomotor activity relative to controls at ages 50 and 60 days. These levels converged for the two genotypes at the oldest ages tested. Findings show markedly different patterns of functional decline for the mth line relative to those previously reported for other life-extended genotypes, suggesting that different life-extending genes have dissimilar effects on preservation of sensory and motor abilities throughout an organism’s lifespan., The mth and control flies were graciously provided by the laboratory of the late Prof. Seymour Benzer. We thank Rosana Magalhaes, Eugenia Fernandes, and Jorge Alves for helpful discussions. This work was supported by funding from the University of California, Irvine, and from the University of Minho, Portugal.

Brain abnormalities in Williams syndrome (WS) have been consistently reported, despite few studies have devoted attention to connectivity between different brain regions in WS. In this study, we evaluated corpus callosum (CC) morphometry: bending angle, length, thickness and curvature of CC using a new shape analysis method in a group of 17 individuals with WS matched with a typically developing group. We used this multimethod approach because we hypothesized that neurodevelopmental abnormalities might result in both volume changes and structure deformation. Overall, we found reduced absolute CC cross-sectional area and volume in WS (mean CC and subsections). In parallel, we observed group differences regarding CC shape and thickness. Specifically, CC of WS is morphologically different, characterized by a larger bending angle and being more curved in the posterior part. Moreover, although CC in WS is shorter, a larger relative thickness of CC was found in all callosal sections. Finally, groups differed regarding the association between CC measures, age, white matter volume and cognitive performance. In conclusions, abnormal patterns of CC morphology and shape may be implicated in WS cognitive and behavioural phenotype., PIC/IC/83290/2007 and PTDC/PSI-PCL/115316/2009 from Fundação para a Ciência e Tecnologia (Portugal). This study was also supported, in part, by grants from the National Institutes of Health (K05 MH070047)

This paper presents the first systematic review and meta-analysis of neuropsychological and brain morphometry studies comparing posterior cortical atrophy (PCA) to typical Alzheimer's disease (tAD). Literature searches were conducted for brain morphometry and neuropsychological studies including a PCA and a tAD group. Compared to healthy controls (HC), PCA patients exhibited significant decreases in temporal, occipital and parietal gray matter (GM) volumes, whereas tAD patients showed extensive left temporal atrophy. Compared to tAD patients, participants with PCA showed greater GM volume reduction in the right occipital gyrus extending to the posterior lobule. In addition, PCA patients showed less GM volume loss in the left parahippocampal gyrus and left hippocampus than tAD patients. PCA patients exhibit significantly greater impairment in Immediate Visuospatial Memory as well as Visuoperceptual and Visuospatial Abilities than patients with tAD. However, tAD patients showed greater impairment in Delayed Auditory/Verbal Memory than patients with PCA. PCA is characterized by significant atrophy of the occipital and parietal regions and severe impairments in visuospatial functioning., JA is funded by a doctoral grant from the Foundation for Science and Technology, FCT (SFRH/BD/64457/2009, co-funded by FSE/POPH). JA and AS are funded by project PIC/IC/83290/2007, which is supported by FEDER (POFC-COMPETE) and FCT. JMS is supported by a fellowship of the project SwitchBox-FP7-HEALTH-2010-grant 259772-2. These organizations had no role in the study design, data collection, analysis, interpretation, or in the decision to submit the paper for publication.

We used event-related potentials (ERPs) to examine the time course of visual emotion processing in schizophrenia. ERPs were recorded in 19 chronic male schizophrenia patients and 16 healthy controls (HC) while they viewed TAPS pictures used to induce positive, negative, or neutral mood, presented in a blocked design across three separate occasions. Electrophysiologically, groups differences were found in early potentials (the first 200 ms of picture viewing): C1, P1, and N1; also, less positive, broadly distributed P2 was found in the patient group. P2 amplitude to negative valenced pictures only was correlated with self-reported negative mood in the patients. The groups did not differ in late-occurring potentials, specifically the late positive potential (500-1000 ms latency window). Patients reported more negative affect before and after the three types of mood induction; however, mood induction influenced both groups in the same direction. Both groups showed similar subjective valence and arousal ratings of evocative stimuli. The ERP results suggest that visual evocative stimuli are differentially processed within the first 200 ms, and that the early stages of visual evocative stimuli processing are abnormal in schizophrenia, irrespective of stimulus valence. The correlation found between sensory abnormalities in negative pictures processing and negative mood suggests a relationship between abnormal sensory processes and increased negative mood experience in patients. Published by Elsevier Ireland Ltd., This work was supported by a Post-Doctoral Grant (BPD/68967/2010) from Fundacao para a Ciencia e a Tecnologia-FCT (Portugal) and by a Research Grant (PTDC/PSI-PCL/116626/2010) funded by FCT and by European Regional Development Fund, both awarded to APP, and by two Grants from the National Institute of Mental Health - NIMH (RO1 MH 040799 grant awarded to RWM; RO3 MM 078036 grant awarded to MAN).

Several studies have shown that cognitive intervention may be beneficial for people with Alzheimer disease (AD), but literature reviews conducted so far, have yielded mixed and inconclusive results. In this work, through an extensive bibliographic search, we aim: (1) to analyze the efficacy of cognitive intervention in patients diagnosed with AD; (2) to provide an estimate of the feasibility of cognitive intervention; and (3) to review available cost-effectiveness data of this approach. Four randomized controlled trials of cognitive intervention, for patients diagnosed with AD that incorporated cognitive intervention and mock intervention control conditions, were included in the analysis. Only the domain of global cognitive functioning, as measured by Mini-Mental State Examination, showed significant intervention effects. No effects were observed in the remaining domains. Concerning feasibility, high rates of completion and adherence were found. A single randomized controlled trial, with unspecified dementia, suggested cognitive intervention to be cost-effective. Given the currently available dearth of well-controlled and focused trials in AD, these results should be carefully interpreted and remain to be confirmed in the future. There is a clear need for more high-quality research., J.A. and R. M. are supported by doctoral Grants from the Portuguese Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia, FCT) (SFRH/BD/64457/2009 and SFRH/BD/65213/2009, co-funded by FSE/POPH). A. S. is funded by the project PIC/IC/83290/2007, supported by FEDER (POFC-COMPETE) and FCT, to develop and assess the effectiveness of a cognitive stimulation tool for Portuguese clinicians.

Background: Task switching, defined as the ability to flexibly switch between tasks in the face of goal shifting, is a central mechanism in cognitive control. Task switching is thought to involve both prefrontal cortex (PFC) and parietal regions. Our previous work has shown that it is possible to modulate set shifting tasks using 1 mA tDCS on both the left dorsolateral prefrontal cortex and the left primary motor area. However, it remains unclear whether the effects of PFC tDCS on task switching are hemisphere-dependent.Objectives: We aimed to test the effects of three types of cross-hemispheric tDCS over the PFC (left anode right cathode [LA-RC], left cathode right anode [LC-RA] and sham stimulation) on participants' performance (reaction time) and accuracy (correct responses) in two task-switching paradigms (i.e., letter/digit naming and vowel-consonant/parity tasks).Methods: Sixteen participants received cross-hemispheric tDCS over the PFC in two task-switching paradigms.Results: The results show that cross-hemispheric tDCS over the PFC modulates task-switching ability in both paradigms. Our results were task and hemisphere-specific, such that in the letter/digit naming task, LA-RC tDCS increased switching performance, whereas LC-RA tDCS improved accuracy. On the other hand, in the vowel-consonant/parity task, LA-RC improved accuracy, and decreased switching performance.Conclusions: Our findings confirm the notion that involvement of the PFC on task switching depends critically on laterality, implying the existence of different roles for the left hemisphere and the right hemisphere in task switching., This work was supported by the Portuguese Foundation for Science and Technology with individual grants (SFRH/BD/41484/2007 and SFRH/BD/64355/2009).

Of the five personality dimensions described by the Big Five Personality Model (Costa and McCrae 1992), Extraversion and Agreeableness are the traits most commonly associated with a pro-social orientation. In this study we tested whether a pro-social orientation, as expressed in terms of Extraversion and Agreeableness, is associated with a specific grey matter phenotype. Fifty-two healthy participants underwent magnetic resonance imaging (MRI) and completed the NEO-Five Factor Inventory (NEO-FFI), a self-report measure of the Big Five personality traits. Voxel-based morphometry (VBM) was used to investigate the correlation between brain structure and the personality traits of Agreeableness and Extraversion. We found that Extraversion was negatively correlated with grey matter density in the middle frontal and orbitofrontal gyri while Agreeableness was negatively correlated with grey matter density in the inferior parietal, middle occipital and posterior cingulate gyri. No positive correlations were found. These results suggest that pro-social personality traits seem to be associated with decreases in grey matter density in more frontal regions for Extraversion, and more posterior regions for Agreeableness., This research was funded by the Portuguese Foundation for Science and Technology (FCT): PIC/IC/83290/2007, which is supported by FEDER (POFC - COMPETE), and postdoctoral grant number: SFRH/BPD/75014/2010.

In recent years, cognitive difficulties associated with normal aging and dementia have been receiving increased attention from both public and scientific communities. With an increase in overall lifespan, promoting healthy cognition has become a priority and a necessity for minimizing and preventing individual and societal burdens associated with cognitive dysfunctions in the elderly. The general awareness concerning the efficacy of preventive (e.g., lifestyles) and palliative treatment strategies of cognitive impairments, related to either healthy or unhealthy trajectories in cognitive aging, is continuously rising. There are several therapeutic strategies which can be broadly classified as either pharmacological or non-pharmacological/psychosocial. In face of the modest evidence for success of pharmacological treatments, especially for dementia related impairments, psychosocial interventions are progressively considered as a complementary treatment. Despite the relative spread of psychosocial interventions in clinical settings, research in this area is rather scarce with evidence for success of these therapies remaining controversial. In this work we provide an evidence based perspective on cognitive intervention(s) for healthy aging, pre-dementia (mild cognitive impairment), and dementia populations. Current evidence and future directions for improving cognitive functions in the elderly are discussed as well.

Background. Schizophrenia is characterized by deficits in emotional prosody (EP) perception. However, it is not clear which stages of processing prosody are abnormal and whether the presence of semantic content contributes to the abnormality. This study aimed to examine event-related potential (ERP) correlates of EP processing in 15 chronic schizophrenia individuals and 15 healthy controls. Method. A total of 114 sentences with neutral semantic content [sentences with semantic content (SSC) condition] were generated by a female speaker (38 with happy, 38 with angry, and 38 with neutral intonation). The same sentences were synthesized and presented in the ‘pure prosody ’ sentences (PPS) condition where semantic content was unintelligible. Results. Group differences were observed for N100 and P200 amplitude : patients were characterized by more negative N100 for SSC, and more positive P200 for angry and happy SSC and happy PPS. Correlations were found between delusions and P200 amplitude for happy SSC and PPS. Higher error rates in the recognition of EP were also observed in schizophrenia : higher error rates in neutral SSC were associated with reduced N100, and higher error rates in angry SSC were associated with reduced P200. Conclusions. These results indicate that abnormalities in prosody processing occur at the three stages of EP processing, and are enhanced in SSC. Correlations between P200 amplitude for happy prosody and delusions suggest a role that abnormalities in the processing of emotionally salient acoustic cues may play in schizophrenia symptomatology. Correlations between ERP and behavioral data point to a relationship between early sensory abnormalities and prosody recognition in schizophrenia., This work was supported by two doctoral grants (doctoral grant no. SFRH/BD/35882/2007 and research grant no. PTDC/PSI-PCL/116626/2010) from Fundac¸a˜o para a Cieˆncia e a Tecnologia (FCT, Portugal) awarded to A.P.P., and by two grants from the National Institute of Mental Health (no. RO1 MH 040799 awarded to R.W.M. and no. RO3 MH 078036 awarded to M.A.N.)

Recent evidence suggests that affect acts as modulator of cognitive processes and in particular that induced mood has an effect on the way semantic memory is used on-line. We used event-related potentials (ERPs) to examine affective modulation of semantic information processing under three different moods: neutral, positive and negative. Fifteen subjects read 324 pairs of sentences, after mood induction procedure with 30 pictures of neutral, 30 pictures of positive and 30 pictures of neutral valence: 108 sentences were read in each mood induction condition. Sentences ended with three word types: expected words, within-category violations, and between-category violations. N400 amplitude was measured to the three word types under each mood induction condition. Under neutral mood, a congruency (more negative N400 amplitude for unexpected relative to expected endings) and a category effect (more negative N400 amplitude for between- than to within-category violations) were observed. Also, results showed differences in N400 amplitude for both within- and between-category violations as a function of mood: while positive mood tended to facilitate the integration of unexpected but related items, negative mood made their integration as difficult as unexpected and unrelated items. These findings suggest the differential impact of mood on access to long-term semantic memory during sentence comprehension., The authors would like to thank to all the participants of the study, as well as to Jenna Mezin and Elizabeth Thompson for their help with data collection. This work was supported by a Doctoral Grant from Fundacao para a Ciencia e a Tecnologia - Portugal (SFRH/BD/35882/2007 to A. P. P.) and by the National Institute of Mental Health (RO1 MH 040799 to R. W. M.; RO3 MH 078036 to M.A.N.).

The main objective of this review is to provide a descriptive analysis of the biological and physiological markers of tactile sensorial processing in healthy, full-term newborns. Research articles were selected according to the following study design criteria: (a) tactile stimulation for touch sense as an independent variable; (b) having at least one biological or physiological variable as a dependent variable; and (c) the group of participants were characterized as full-term and healthy newborns; a mixed group of full-term newborns and preterm newborns; or premature newborns with appropriate-weight-for-gestational age and without clinical differences or considered to have a normal, healthy somatosensory system. Studies were then grouped according to the dependent variable type, and only those that met the aforementioned three major criteria were described. Cortisol level, growth measures, and urinary catecholamine, serotonin, and melatonin levels were reported as biological-marker candidates for tactile sensorial processing. Heart rate, body temperature, skin-conductance activity, and vagal reactivity were described as neurovegetative-marker candidates. Somatosensory evoked potentials, somatosensory evoked magnetic fields, and functional neuroimaging data also were included., Fundação Bial - 42/08, Fundação para a Ciência e a Tecnologia (FCT) - SFRH/BD/44113/2008

Film clips are an important tool for evoking emotional responses in the laboratory. When compared with other emotionally potent visual stimuli (e.g., pictures), film clips seem to be more effective in eliciting emotions for longer periods of time at both the subjective and physiological levels. The main objective of the present study was to develop a new database of affective film clips without auditory content, based on a dimensional approach to emotional stimuli (valence, arousal and dominance). The study had three different phases: (1) the pre-selection and editing of 52 film clips (2) the self-report rating of these film clips by a sample of 113 participants and (3) psychophysiological assessment [skin conductance level (SCL) and the heart rate (HR)] on 32 volunteers. Film clips from different categories were selected to elicit emotional states from different quadrants of affective space. The results also showed that sustained exposure to the affective film clips resulted in a pattern of a SCL increase and HR deceleration in high arousal conditions (i.e., horror and erotic conditions). The resulting emotional movie database can reliably be used in research requiring the presentation of non-auditory film clips with different ratings of valence, arousal and dominance., Portuguese Foundation for Science and Technology with individual grants (SFRH/BD/41484/2007 and SFRH/BD/64355/2009)

Williams syndrome is characterized by impairments in executive functions (EFs). However, it remains unknown how distinct types of EFs relate to intelligence in this syndrome. The present study analyzed performance on working memory, inhibiting and shifting, and its links to IQ in a sample of 17 individuals with WS, and compared them with a group of 17 typically developing individuals matched on chronological age and gender. In conclusion, our results suggest that working memory, inhibiting, and shifting relate differently to intelligence in WS as well as in typical development, with working memory being the EF most closely related to intelligence in both groups. Notably, the magnitude of the associations between the three EFs and IQ was substantially higher in the WS group than in the TD group, bringing further confirmation to the notion that frontal lobe impairments may produce a general compromise of several EFs, Portuguese Foundation for Science and Technology (FCT) (grantPTDC/PSI-PCL/115316/ 2009) and by Fundación Alicia Koplowitz(5thCall for Grants for Research in Childhood and Adolescent Psychiatry Early Neurodegenerative Diseases)

This study compares narrative production among three syndromes with genetic microdeletions: Williams syndrome (WS), Smith-Magenis syndrome (SMS), and Prader-Willi syndrome (PWS), characterized by intellectual disabilities and relatively spared language abilities. Our objective is to study the quality of narrative production in the context of a common intellectual disability. To elicit a narrative production, the task Frog! Where Are You was used. Then, structure, process, and content of the narrative process were analysed in the three genetic disorders:WS (n52), SMS (n52), and PWS (n52). Data show evidence of an overall low narrative quality in these syndromes, despite a high variability within different measures of narrative production. Results support the hypothesis that narrative is a highly complex cognitive process and that, in a context of intellectual disability, there is no evidence of particular ‘hypernarrativity’ in these syndromes., This research was supported by the grants FEDER – 1

Individuals with Williams syndrome display indiscriminate approach towards strangers. Neuroimaging studies conducted so far have linked this social profile to structural and/or functional abnormalities in WS amygdala and prefrontal cortex. In this study, the neuropsychological hypotheses of amygdala and prefrontal cortex involvement in WS hypersociability was explored using three behavioral tasks – facial emotional recognition task, a social approach task and a go no/go task. Thus, a group 15 individuals with Williams syndrome was compared to two groups of normal developing individuals – a group of 15 individuals matched for chronological age (CA) and 15 individualsmatched for mental age (MA), and sex. Individuals with WS present a specific impairment in recognizing negative facial expressions and do not display impairments in response inhibition when compared with typically developing groups. Although these findings partially support the amygdala contribution to WS hypersociability, we found that general cognitive functioning predicted this performance. Additionally, individuals with WS did not differ from both CA and MA groups in the recognition of angry facial expressions, a finding suggesting that they are actually able to identify stimuli associated with social threat. Overall, the results seem to indicate that this social profile must be understood within a developmental framework., Fundação para a Ciência e a Tecnologia (FCT) - bolsa PIC/IC/83290/2007

The auditory system can encode interaural delays in highpass-filtered complex sounds by phase locking to their slowly modulating envelopes. Spectrotemporal analysis of interaurally time-delayed highpass waveforms reveals the presence of a concomitant interaural level cue. The current study systematically investigated the contribution of time and concomitant level cues carried by positive and negative envelope slopes of a modified sinusoidally amplitude-modulated (SAM) high-frequency carrier. The waveforms were generated from concatenation of individual modulation cycles whose envelope peaks were extended by the desired interaural delay, allowing independent control of delays in the positive and negative modulation slopes. In experiment 1, thresholds were measured using a 2-interval forced-choice adaptive task for interaural delays in either the positive or negative modulation slopes. In a control condition, thresholds were measured for a standard SAM tone. In experiment 2, decision weights were estimated using a multiple-observation correlational method in a single-interval forced-choice task for interaural delays carried simultaneously by the positive, and independently, negative slopes of the modulation envelope. In experiment 3, decision weights were measured for groups of 3 modulation cycles at the start, middle, and end of the waveform to determine the influence of onset dominance or recency effects. Results were consistent across experiments: thresholds were equal for the positive and negative modulation slopes. Decision weights were positive and equal for the time cue in the positive and negative envelope slopes. Weights were also larger for modulations cycles near the waveform onset. Weights estimated for the concomitant interaural level cue were positive for the positive envelope slope and negative for the negative slope, consistent with exclusive use of time cues., We thank Virginia M. Richards and Bruce G. Berg for helpful discussions. We also thank Brian C. J. Moore and an anonymous reviewer for their insightful comments on an earlier draft of the manuscript. Work supported by grants from the National Science Council, Taiwan NSC 98-2410-H-008-081-MY3 and NIH R01DC009659.

Empathy entails the capacities to resonate with another person’s emotions, understand his/her thoughts and feelings, separate our own thoughts and emotions from those of the observed and responding with the appropriate prosocial and helpful behavior. While there is abundant research on the neurobiological mechanisms of some components of empathy (e.g., emotional contagion), few studies have considered the neurobiological mechanisms underlying the empathic response. The present study explores psychophysiological correlates (skin conductance level and the interbeat interval) as a function of the empathic response while participants watch and respond to actors portraying emotionally laden vignettes. Forty undergraduate psychology students were each presented with 40 emotional vignettes of positive or negative valence and asked to choose among three different empathic responses while their electrodermal and cardiac responses were measured. Overall, the study shows that higher levels of additive empathy are associated with increased cardiac activity (i.e., decreased Interbeat Interval) but not electrodermal activity., BIAL Foundation by the grant ‘‘The Neuropsychophysiological Basis of Empathy: The role of neuroendocrine; autonomic and central nervous system variables (89/08)’’ that supported this research.

Williams Syndrome is a neurodevelopmental disorder, characterised by a submicroscopic deletion on chromosome 7 q11.23 associated with a particular cognitive and socio-emotional profile. We have previously described a case study of a Williams Syndrome patient in 2005 that has further been engaged in neurocognitive rehabilitaion sessions. In this article, we compared the patient's cognitive profile at two time points (2005 and 2009) analyzing the impact of a cognitive rehabilitation programe, in terms of several neurocognitive measures. Overall, an improvement on general cognitive functioning was evident from 2005 to 2009 assessment that was manly due to a significant increase in performance measures that contrasted with stability in verbal IQ measures. We propose that the use of intervention programmes can be generalised to specific populations with cognitive impairment.

Williams syndrome (WS) is a neurodevelopmental disorder, with an intriguing cognitive phenotype. Previous studies found support for an atypical profile of fictional narrative production in WS (Gonçalves et al. The British Journal of Developmental Disabilities, 56(111), 89-109, 2010). This study aimed at testing if the same profile is observed when individuals with WS tell autobiographical narratives. Using a new scoring system, structural (coherence), process (complexity) and content (multiplicity) aspects of autobiographical narrative production were analyzed in WS. Results suggest that individuals with WS produce autobiographical narratives that are significantly less coherent and complex than typically developing controls, although similar to controls in terms of content diversity. These findings point out to deficits in autobiographical narrative production in WS, suggesting the relative preservation of the social dimension of narrative production. These results also support the hypothesis that fictional and autobiographical narrative production may rely on different neurocognitive mechanisms., Fundação para a Ciência e a Tecnologia (FCT) - bolsas SFRH/BD/35882/2007, PIC/IC/83290/2007

One of the most intriguing characteristics of Williams Syndrome individuals is their hypersociability. The amygdala has been consistently implicated in the etiology of this social profile, particularly given its role in emotional and social behavior. This study examined amygdala volume and symmetry in WS individuals and in age and sex matched controls. Magnetic resonance imaging scans were obtained on a GE 1.5-T magnet with 1.5- mm contiguous slices and were used to measure whole gray matter, white matter and cerebrospinal fluid volumes, as well as amygdala volume (right and left). Results revealed significantly reduced intracranial volume in individuals with WS, compared with controls. There were no differences between groups in absolute amygdalae volume, although there was a relative increase in amygdalae volumes, when adjusted for total intracranial content. There were no inter-hemispheric differences in amygdalae volumes in both groups. These results suggest a relative increase in amygdala volume in WS compared with healthy controls that likely reflects abnormal neurodevelopmental processes of midline brain structures., This research was supported by the grants PIC/IC/83290/2007 from Fundac¸a˜o para a Cieˆncia e Tecnologia (Portugal) and Fundacio´n Alicia Koplowitz. (V convocatoria de 2009. Ayudas a la investigacio´n en psiquiatrı´a de la infancia y adolescencia enfermedades neurodegenerativas tempranas)

Obsessive Compulsive Disorder (OCD) involves failures in two main inhibitory processes, namely cognitive (obsessions) and behavioral (compulsions). Recent research has supported two cortical-subcortical pathways on OCD pathogenesis: (a) the frontostriatal loop (dorsolateral-caudate-striatum-thalamus) responsible for impairments of behavioral inhibition; (b) the orbitofrontal loop (orbitofrontal, medial prefrontal and cingulate) responsible for impairments with cognitive inhibitory processes. These failures in both cognitive and motor inhibitory systems may mediate several neuropsychological deficits in these patients, namely memory, attention, planning and decision making. But are those deficits related to specific hemispheric effects, namely functional imbalance between hemispheres? In this article we hypothesize that: (1) OCD patients have an inter-hemispheric functional imbalance, probably due to inadequate filtering at the thalamic level; (2) the restoration of inter-hemispheric balance, will be correlative to symptomatic improvement.

In this study, we tested the effects of transcranial Direct Current Stimulation (tDCS) on two set shifting tasks. Set shifting ability is defined as the capacity to switch between mental sets or actions and requires the activation of a distributed neural network. Thirty healthy subjects (fifteen per site) received anodal, cathodal and sham stimulation of the dorsolateral prefrontal cortex (DLPFC) or the primary motor cortex (M1). We measured set shifting in both cognitive and motor tasks. The results show that both anodal and cathodal single session tDCS can modulate cognitive and motor tasks. However, an interaction was found between task and type of stimulation as anodal tDCS of DLPFC and M1 was found to increase performance in the cognitive task, while cathodal tDCS of DLPFC and M1 had the opposite effect on the motor task. Additionally, tDCS effects seem to be most evident on the speed of changing sets, rather than on reducing the number of errors or increasing the efficacy of irrelevant set filtering., FCT SFRH/BD/41484/2007 and SFRH/BD/64355/ 2009

OCD has been hypothesized to involve the failures in both cognitive and behavioral inhibitory processes. There is evidence that the hyperactivation of cortical–subcortical pathways may be involved in the failure of these inhibitory systems associated with OCD. Despite this consensus on the role of frontal–subcortical pathways in OCD, recent studies have been showing that brain regions other than the frontal–subcortical loops may be needed to understand the different cognitive and emotional deficits in OCD. Some studies have been finding evidence for decreased metabolic activity in areas such as left inferior parietal and parieto- occipital junction suggesting the possible existence of visual processing deficits. While there has been inconsistent data regarding visual processing in OCD, recent studies have been claiming that these patients have abnormal patterns of visual processing social rich stimuli, particularly emotional arousing stimuli. Thus, in this article, we hypothesize that the fronto-subcortical activation consistently found in OCD may be due to a deactivation of occipital/parietal regions associated with visual-perceptual processing of incoming social rich stimuli. Additionally, this dissociation may be more evident as the emotional intensity of the social stimulus increases.

This study presents a set of sentence contexts and their cloze probabilities for European Portuguese children and adolescents. Seventy-three sentence contexts (35 low- and 38 high-constraint sentence stems) were presented to 90 children and 102 adolescents. Participants were asked to complete the sentence contexts with the first word that came to mind. For each sentence context, responses were listed and cloze probabilities of the words that were chosen to complete the sentence context were computed. Additionally, idiosyncratic and invalid responses (structural and semantic errors) were analyzed. A high degree of consistency in responses among the two age samples (children and adolescents) was found, along with a decrease of idiosyncratic and invalid responses in older participants. These results shed light on age-related changes in the effects of linguistic context on word production, and also in knowledge’s representation. The full set of norms may be downloaded from http://brm.psychonomic-journals.org/content/supplemental, This study was funded by a doctoral grant (SFRH/BD/35882/2007), Fundação para a Ciência e a Tecnologia (FCT)

Williams Syndrome (WS) is a genetic neurodevelopmental disorder caused by a submicroscopic deletion on chromosome 7 q11.23. This is a systemic disorder in which cardiac problems and mental retardation are the key phenotypic symptoms. Although displaying a general cognitive impairment, they are most often described as exhibiting a peak and valley profile, with relative sparing of language and face processing abilities and severe impairment of visual–spatial cognition. In this study, we conducted a detailed cognitive assessment using Wechsler Intelligence Scales on a WS and a normal development control group. To explore the hypothesis of a dissociative cognitive architecture in WS, performance on subtests, factorial indexes and composite measures of Verbal, Performance and Full Scale Intelligence Quotient were analysed. Individuals with WS were found to score in Full Scale Intelligence Quotient (FSIQ) within mild to moderate mental retardation interval, and had significantly lower scores in all measures when they were compared with the normal development group. However, a specific intragroup cognitive profile was found for Williams Syndrome (confirming Mervis’ definition of the WS cognitive profile) along with a specific developmental pathway (absence of an age-associated cognitive decline)., Fundação para a Ciência e a Tecnologia (FCT), This research was supported by the grants POCTI/PSI/58364/ 2004 and SFRH/BD/16091/2004

Williams syndrome (WS) is a neurodevelopmental genetic disorder often described as being characterized by a dissociative cognitive architecture, in which profound impairments of visuo-spatial cognition contrast with relative preservation of linguistic, face recognition and auditory short-memory abilities. This asymmetric and dissociative cognition has been also proposed to characterize WS memory ability, with sparing of auditory short-term memory and impairment of spatial and long-term memory abilities. In this study, we explored the possibility of a double memory dissociation in WS (short- versus long-term memory; verbal versus visual memory). Thus, verbal memory abilities were assessed using California Verbal Learning Test and Digit Span and Rey-Osterrieth Complex Figure and Corsi Blocks was used to assess visual–spatial memory abilities. Overall, WS subjects were found to present a generalized significant impairment in verbal and visuo-spatial components either in short- or long-term memory. In sum, data from this study brings support for a developmental delay hypothesis, rather than a double dissociation within memory systems in WS., Fundação para a Ciência e Tecnologia (FCT) - POCTI/PSI/58364/2004 and SFRH/BD/16091/2004

This study aimed to clarify the relationship between changes in the patients' narratives and therapeutic outcomes. Two patients were selected from three psychotherapeutic models (cognitive, narrative, and prescriptive therapies), one with good therapeutic outcome and the other with bad therapeutic outcome. Sessions from the initial, middle, and final phases for each patient were evaluated in terms of narrative structural coherence, process complexity, and content diversity. Differences between patients' total narrative production were found at the end of the therapeutic process. Good outcome cases presented a higher statistically significant total narrative change than poor outcome cases.

Recently, cognitive approaches to therapy have been facing an increasingly constructivist orientation, in which persons are viewed as actively constructing their own reality from their deep/tacit/unconscious knowledge representation. This paper begins with the presentation of the main assumptions of the constructive movement in cognitive therapy on the nature and change of cognitive representations. It is asserted that at the deep/tacit/unconscious levels, knowledge is represented in analogical and metaphorical ways. The use of metaphors is suggested as a therapeutic tool to access and change tacit/unconscious levels of cognitive representation. A cognitive adaptation of the multiple-embedded-metaphor strategy is presented and illustrated., (undefined)

Cognitive neuroscience research has been recently advanced as central [o r a scientific foundation of psychotherapeutic treatment In fact, understanding how the maintenance, survival or neurological change is mediated psychological pro cesses, is fundamental for advancing our know ledge about the mechanisms of psychotherapy treatment. This study is an attempt to bring psychotherapy closer to neurocognitive research in order to foster understanding on the neurobiological effects 'if therapeutic equivalent tasks in reverting the effects (if chronic stress. More specifically, this study aims: (1) To compare spatial working memory and behavioural flexibility performances in groups (if adult rats submitted to chronic unpredictable stress and age-matched controls: and (2) To test the modulatory effects of a cognitive treatment-equivalent task intended to counteract the effects of chronic unpredictable stress. The results confirm that stress impairs reference memory as well as spatial working memory and reversal learning tasks. More important, this study also demonstrates that the detrimental effects of stress on spatial working memory can be attenuated by a cognitive treatment equivalent task introduced in the late phase of the stress exposure, (Ill effect that seems to be group (i.e., stressed animals) and task specific (i.e, spatial working memory)., La investigación en neurociencias cognitivas ha avanzado recientemente hasta alcanzar un lugar primordial en la búsqueda de un fundamento científico para el tratamiento psicoterapéutico. De hecho, la comprensión de cómo el mantenimiento. La supervivencia o el cambio neurológico están mediatizados por procesos psicológicos es fundamental para avanzar nuestro conocimiento sobre los mecanismos de la psicoterapia. Este estudio es un intento de aproximar la psicoterapia a la investigación neurocognitiva y tiene como objetivo fomentar la comprensión de los procesos neurobiológicos de reversión de los efectos del estrés crónico mediante tareas análogas a las terapéuticas. En concreto, sus objetivos son: (1) comparar la memoria de trabajo espacia l y la flexibilidad conductual en la ejecución de tareas en un grupo de rata s adultas sometidas a estrés crónico impredecible y un grupo control de ratas de la misma edad; y (2) compro bar los efectos moduladores de una tarea análoga al tratamiento cognitivo que pretende contrarresta r los efectos del estrés crónico impredecible. Los resultados confirma n que el estrés daña la memoria de referencia as í como la memoria de trabajo espacial y las tareas de inversión de aprendiz aje. Más aún, este estudio demuestra también que los efectos perjudiciales del estrés sobre la memoria de trabajo espacial pueden ser atenuados por una tarea análoga a un tratamiento cognitivo introducida en la última fase de la exposición al estrés, efecto que parece especifico del grupo (animales estresados) y de la tarea (memoria de trabajo espacial).