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Cell volumes of neoplastic lymphocytes collected from lymph nodes of 53 patients with non-Hodgkin's lymphoma were compared to lymphocytes from 18 patients with reactive hyperplasia. The mean cell volume (MCV) and the modal volume (MV) of neoplastic lymphocytes were larger than the MCV and MV of lymphocytes from reactive hyperplasia. The cell volumes of neoplastic lymphocytes from patients with non-Hodgkin's lymphoma were more heterogeneous within and among cases than observed in volumes from lymphocytes of patients with reactive hyperplasia. The cell volumes of neoplastic lymphocytes corresponded to subgroups within the Rappaport Classification and the Working Formulation. Cell volumes of neoplastic cells from low-grade lymphomas were smaller than intermediate grade lymphomas which in turn were smaller than high-grade lymphomas. When cases of NHL were placed into three subtypes based on the MCV, large cell lymphomas had a significantly shorter survival then small and intermediate cell lymphomas at 12 months. However, a stepwise multiple regression analysis failed to demonstrate any independent value of cell volume in the prediction of survival.

A patient with a large tumor of the head and body of the pancreas had a Whipple procedure performed after the intraoperative diagnosis of "mesenchymal tumor" was made. The final histopathologic diagnosis was malignant fibrous histiocytoma arising in the pancreas. The patient died of postoperative complications, and no metastatic disease was found at autopsy. This is the first detailed description of a primary pancreatic malignant fibrous histiocytoma.

We have analyzed the alterations that occur in the patterns of protein synthesis of Tetrahymena thermophila cells when these cells are exposed to a sublethal heat treatment. At least 11 major polypeptides, ranging in size from 97,000 to 27,000 daltons, are produced when the incubation temperature of Tetrahymena cultures is raised from 29 to 41 degrees C. The kinetics of appearance and disappearance appears to differ for each one of these heat-induced polypeptides, suggesting that elaborate mechanisms might operate in the regulation of the expression of this group of genes.