1,351 results on '"Cong Gao"'
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1102. A Feature-Based Approach for the Redefined Link Prediction Problem in Signed Networks
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Li, Xiaoming, Fang, Hui, Zhang, Jie, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1103. Empirical Analysis of Factors Influencing Twitter Hashtag Recommendation on Detected Communities
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Alsini, Areej, Datta, Amitava, Li, Jianxin, Huynh, Du, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1104. A Hierarchical Bayesian Factorization Model for Implicit and Explicit Feedback Data
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Nguyen, ThaiBinh, Takasu, Atsuhiro, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1105. Group Recommender Model Based on Preference Interaction
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Zheng, Wei, Li, Bohan, Wang, Yanan, Yin, Hongzhi, Li, Xue, Guan, Donghai, Qin, Xiaolin, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1106. Fair Recommendations Through Diversity Promotion
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Lhérisson, Pierre-René, Muhlenbach, Fabrice, Maret, Pierre, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1107. Identification of Grey Sheep Users by Histogram Intersection in Recommender Systems
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Zheng, Yong, Agnani, Mayur, Singh, Mili, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1108. Detect Tracking Behavior Among Trajectory Data
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Xu, Jianqiu, Zhou, Jiangang, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1109. PowerLSTM: Power Demand Forecasting Using Long Short-Term Memory Neural Network
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Cheng, Yao, Xu, Chang, Mashima, Daisuke, Thing, Vrizlynn L. L., Wu, Yongdong, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1110. Carbon: Forecasting Civil Unrest Events by Monitoring News and Social Media
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Kang, Wei, Chen, Jie, Li, Jiuyong, Liu, Jixue, Liu, Lin, Osborne, Grant, Lothian, Nick, Cooper, Brenton, Moschou, Terry, Neale, Grant, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1111. SWYSWYK: A New Sharing Paradigm for the Personal Cloud
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Tran-Van, Paul, Anciaux, Nicolas, Pucheral, Philippe, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1112. Tools and Infrastructure for Supporting Enterprise Knowledge Graphs
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Bhatia, Sumit, Rajshree, Nidhi, Jain, Anshu, Aggarwal, Nitish, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1113. Location-Aware Human Activity Recognition
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Nguyen, Tam T., Fernandez, Daniel, Nguyen, Quy T. K., Bagheri, Ebrahim, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1114. An Interactive Web-Based Toolset for Knowledge Discovery from Short Text Log Data
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Stewart, Michael, Liu, Wei, Cardell-Oliver, Rachell, Griffin, Mark, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1115. Color-Sketch Simulator: A Guide for Color-Based Visual Known-Item Search
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Lokoč, Jakub, Phuong, Anh Nguyen, Vomlelová, Marta, Ngo, Chong-Wah, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1116. Privacy and Utility Preservation for Location Data Using Stay Region Analysis
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Dash, Manoranjan, Teo, Sin G., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1117. Mining Load Profile Patterns for Australian Electricity Consumers
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Nguyen, Vanh Khuyen, Zhang, Wei Emma, Sheng, Quan Z., Merefield, Jason, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1118. Fault Detection and Localization in Distributed Systems Using Recurrent Convolutional Neural Networks
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Qi, Guangyang, Yao, Lina, Uzunov, Anton V., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1119. Making Use of External Company Data to Improve the Classification of Bank Transactions
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Vollset, Erlend, Folkestad, Eirik, Gallala, Marius Rise, Gulla, Jon Atle, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1120. Identifying Unreliable Sensors Without a Knowledge of the Ground Truth in Deceptive Environments
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Yazidi, Anis, Oommen, B. John, Goodwin, Morten, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1121. Distributed Training Large-Scale Deep Architectures
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Zou, Shang-Xuan, Chen, Chun-Yen, Wu, Jui-Lin, Chou, Chun-Nan, Tsao, Chia-Chin, Tung, Kuan-Chieh, Lin, Ting-Wei, Sung, Cheng-Lung, Chang, Edward Y., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1122. Discovering Group Skylines with Constraints by Early Candidate Pruning
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Lin, Ming-Yen, Lin, Yueh-Lin, Hsueh, Sue-Chen, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1123. Comparing MapReduce-Based k-NN Similarity Joins on Hadoop for High-Dimensional Data
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Čech, Přemysl, Maroušek, Jakub, Lokoč, Jakub, Silva, Yasin N., Starks, Jeremy, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
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- 2017
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1124. A Higher-Fidelity Frugal Quantile Estimator
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Yazidi, Anis, Hammer, Hugo Lewi, John Oommen, B., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
- Published
- 2017
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1125. Querying and Mining Strings Made Easy
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Sahli, Majed, Mansour, Essam, Kalnis, Panos, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cong, Gao, editor, Peng, Wen-Chih, editor, Zhang, Wei Emma, editor, Li, Chengliang, editor, and Sun, Aixin, editor
- Published
- 2017
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1126. Annexin A2 binds to vimentin and contributes to porcine reproductive and respiratory syndrome virus multiplication
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Xiao-Bo Chang, Yong-Qian Yang, Jia-Cong Gao, Kuan Zhao, Jin-Chao Guo, Chao Ye, Cheng-Gang Jiang, Zhi-Jun Tian, Xue-Hui Cai, Guang-Zhi Tong, and Tong-Qing An
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Veterinary medicine ,SF600-1100 - Abstract
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is an important globally distributed and highly contagious pathogen that has restricted cell tropism in vivo and in vitro. In the present study, we found that annexin A2 (ANXA2) is upregulated expressed in porcine alveolar macrophages infected with PRRSV. Additionally, PRRSV replication was significantly suppressed after reducing ANXA2 expression in Marc-145 cells using siRNA. Bioinformatics analysis indicated that ANXA2 may be relevant to vimentin, a cellular cytoskeleton component that is thought to be involved in the infectivity and replication of PRRSV. Co-immunoprecipitation assays and confocal analysis confirmed that ANXA2 interacts with vimentin, with further experiments indicating that the B domain (109–174 aa) of ANXA2 contributes to this interaction. Importantly, neither ANXA2 nor vimentin alone could bind to PRRSV and only in the presence of ANXA2 could vimentin interact with the N protein of PRRSV. No binding to the GP2, GP3, GP5, nor M proteins of PRRSV was observed. In conclusion, ANXA2 can interact with vimentin and enhance PRRSV growth. This contributes to the regulation of PRRSV replication in infected cells and may have implications for the future antiviral strategies.
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- 2018
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1127. A Study on the Utilization of Clayey Soil as Embankment Material through Model Bearing Capacity Tests
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Myoung-Soo Won, Christine P. Langcuyan, and Yu-Cong Gao
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bearing capacity ,soft clay ,composite geotextiles ,embankment material ,reinforced clay ,bearing capacity ratio ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The Saemangeum seawall, located on the western coast of Korea, is 33.8 km long and is known as the longest embankment in the world. The Saemangeum project is underway for road, railway, and port constructions for internal development. In the Saemangeum area, suitable granular soil for embankment material is difficult to obtain. However, silty clay is widely distributed. In this study, a series of model-bearing capacity tests were conducted as a basic study for using clayey soils as embankment materials. The model bearing capacity tests were carried out using a standard metal mold and a customized metal box. The test results showed that clayey soil, with normal moisture content (NMC), exhibited a large deformation and low bearing capacity. However, when the clay was well-compacted, with optimum moisture content (OMC), it exhibited a higher bearing capacity than dense sand. In addition, when crushed gravel and composite geotextiles were placed in the clayey soil with NMC, the bearing capacity was higher than that of dense sand. From the viewpoint of the bearing capacity, it is considered that clayey soil can be used as an embankment material when clay, crushed gravel, and composite geotextiles are properly combined.
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- 2020
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1128. Design Intend Solving: Dynamic Composition Method for Innovative Design Based on Virtual Cloud Manufacturing Resource Generators
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Yi-Cong Gao, Yi-Xiong Feng, Jin Cheng, Jianrong Tan, and Zheng Hao
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Mechanical engineering and machinery ,TJ1-1570 - Abstract
Recently, there has been growing interest in composition of cloud manufacturing resources (CMRs). Composition of CMRs is a feasible innovation to fulfill the user request while single cloud manufacturing resource cannot satisfy the functionality required by the user. In this paper, we propose a new case-based approach for the composition of CMRs. The basic idea of the present approach is to provide a computational framework for the composition of CMRs by imitating the common design method of reviewing past designs to obtain solution concepts for a new composite cloud manufacturing resource (CCMR). A notion of virtual cloud manufacturing resource generators (VCMRGs) is introduced to conceptualize and represent underlying CCMRs contained in existing CCMRs. VCMRGs are derived from previous CCMRs and serve as new conceptual building blocks for the composition of CMRs. Feasible composite CMRs are generated by combining VCMRGs using some adaptation rules. The reuse of prior CCMRs is accomplished via VCMRGs within the framework of case-based reasoning. We demonstrate that the proposed approach yields lower execution time for fulfilling user request and shows good scalability.
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- 2013
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1129. Equilibrium Design Based on Design Thinking Solving: An Integrated Multicriteria Decision-Making Methodology
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Yi-Xiong Feng, Yi-Cong Gao, Xuan Song, and Jian-Rong Tan
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Mechanical engineering and machinery ,TJ1-1570 - Abstract
A multicriteria decision-making model was proposed in order to acquire the optimum one among different product design schemes. VIKOR method was introduced to compute the ranking value of each scheme. A multiobjective optimization model for criteria weight was established. In this model, projection pursuit method was employed to identify a criteria weight set which could keep classification information of original schemes to the greatest extent, while PROMETHEE II was adopted to keep sorting information. Dominance based multiobjective simulated annealing algorithm (D-MOSA) was introduced to solve the optimization model. Finally, an example was taken to demonstrate the feasibility and efficiency of this model.
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- 2013
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1130. The association baseline NIH Stroke Scale score with ABO blood-subtypes in young patients with acute ischemic stroke.
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Ning Yang, Bin Zhang, Longchang Xie, Jianrui Yin, Yihua He, Xinguang Yang, and Cong Gao
- Subjects
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ABO blood group system , *STROKE , *ISCHEMIA , *THROMBOSIS - Abstract
Objectives The presence of the A and B blood group antigens has been associated with risk of arterial thrombosis. The aim of the current study was to design a new simpler form of National Institutes of Health Stroke Scale (NIHSS) for use on admission, and assess the association of blood groups with NIHSS score in young stroke patients. Methods We conducted this study in 1311 young Chinese adults with acute ischemic cerebral stroke. The outcome measures included a composite favorable outcome (defined as a modified Rankin Scale (mRS) of 0 or 2) and poor outcome (defined as a modified Rankin Scale score of 3 or 6) at discharge; a minor strokes (NIHSS scores 0-5) and severe strokes (NIHSS scores ≥6). Logistic regression analyses were used to determine the association between ABO blood groups and stroke severity. Results Regression analysis confirmed in relative to patients with AB subtype, Oxfordshire community stroke project classification (OCSP) subtype and serum white blood cell (WBC) were the major predictors for stroke severity. Meanwhile, diabetes, serum triglyceride and uric acid levels were determined as independent indicators of stroke severity in A, B and O blood subtype respectively. The optimal cutoff score of the baseline NIHSS was ≤5 for patients with non-O subtype, the optimal cutoff score of the baseline NIHSS was ≤7 for patients with blood O subtype. Conclusions Our analysis provide compelling information regarding the ABO blood groups differences in predictors of stroke severity and the different validity of NIHSS scores in predicting prognosis at discharge between O subtype and non-O subtype. [ABSTRACT FROM AUTHOR]
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- 2014
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1131. Development of a cell-based assay for the detection of anti-aquaporin 1 antibodies in neuromyelitis optica spectrum disorders.
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Youming Long, Yangbo Zheng, Fulan Shan, Mengyu Chen, Yongxiang Fan, Bin Zhang, Cong Gao, Qingchun Gao, and Ning Yang
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BIOLOGICAL assay , *AQUAPORINS , *IMMUNOGLOBULINS , *NEUROMYELITIS optica , *SPECTRUM analysis , *MULTIPLE sclerosis , *BLOOD serum analysis - Abstract
Objective To develop a cell-based assay (CBA) to detect aquaporin 1 (AQP1) antibodies and determine sensitivity/specificity in patients with neuromyelitis optica (NMO) spectrum disorders. Methods A HEK-293T transfected cell model expressing AQP1 was established and detected to be serum AQP1 antibodies. Results AQP1 antibodies were present in 73/98 (74.5%) AQP4 antibody-positive patients. Some AQP4 antibody-negative patients were also AQP1 antibody-positive. Test sensitivity was 74.5% in 98 AQP4 antibody-positive patients. Test specificity was 79.6% in 67 multiple sclerosis (MS) patients and 31 controls. Conclusion A sensitive and simple CBA was developed to detect serum AQP1 antibodies. AQP1 antibodies were mainly present in NMO and its high-risk syndrome, but also in some MS patients. [ABSTRACT FROM AUTHOR]
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- 2014
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1132. Geospatial data analysis : from querying to visualized exploration
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Guo Tao, Cong Gao, and Interdisciplinary Graduate School (IGS)
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Engineering::Computer science and engineering [DRNTU] ,Geospatial analysis ,Information retrieval ,Computer science ,computer.software_genre ,computer - Abstract
With the proliferation of social sharing platforms (e.g., Foursquare and Yelp) and online social media (e.g., Twitter, Facebook and Instagram), large collections of geospatial data are becoming available, such as geo-tagged photos and geo-textual posts. The availability of substantial amount of such geospatial objects gives prominence to the spatial keyword query, which is to find the geo-textual objects that best match the query arguments exploiting both locations and textual descriptions. As an important type of spatial keyword query, the m-closest keywords (mCK) query is useful in many applications such as detecting locations of web resources. However, the existing work does not study the intractability of this problem and only provides exact algorithms, which are computationally expensive. Since the volume of geospatial data keeps growing rapidly, an emerging challenge is how to explore and understand the data before we analyze it. Presenting geospatial data through a visualization system is no doubt the most efficient way for end users, however, a remaining challenge is how to read the oversize data effectively. We aim at solving the challenge from two perspectives. On the one hand, the users may be exhausted and distracted if too many results are displayed at the same time. Following the rule of “Less is more”, we can show a small set of representative objects to users instead of the whole collection. Thus, the challenge in this problem is how to build such a map rendering system that efficiently selects a small set of representative objects from the current region of user’s interest. On the other hand, as the characteristics of geospatial data, the objects of similar types or functions may tend to appear together. Such circumstance is common in real-life, for example, there are more shopping malls grouping in the downtown area of a city than the living zones. To this end, we can explore the geo-spatial data by dividing the whole space into several functional regions according to the utilities of the geo-spatial objects. First, we study the m-closest keywords (mCK) query, finding a group of objects such that they cover all query keywords and have the smallest diameter, which is defined as the largest distance between any pair of objects in the group. We prove that the problem of answering mCK queries is NP-hard. We first devise a greedy algorithm that has an approximation ratio of 2. Then, we observe that an mCK query can be approximately answered by finding the circle with the smallest diameter that encloses a group of objects together covering all query keywords. We prove that the group enclosed in the circle can answer the mCK query with an approximation ratio of 2/√3. Based on this, we develop an algorithm for finding such a circle exactly, which has a high time complexity. To improve efficiency, we propose another two algorithms that find such a circle approximately, with a ratio of ( 2/√3+ ϵ). Finally, we propose an exact algorithm that utilizes the group found by the ( 2/√3+ϵ)-approximation algorithm to obtain the optimal group. We conduct extensive experiments using real-life datasets. The experimental results offer insights into both efficiency and accuracy of the proposed approximation algorithms, and the results also demonstrate that our exact algorithm outperforms the best known algorithm by an order of magnitude. Next, we study how to develop an interactive visualization map exploration system. We propose that such system should support the following desirable features: representativeness, visibility constraint, zooming consistency, and panning consistency. The first two constraints are fundamental challenges to a map exploration system, which aims to efficiently select a small set of representative objects from the current region of user’s interest, and any two selected objects should not be too close to each other for users to distinguish in the limited space of a screen. We formalize it as the Spatial Object Selection (sos) problem, prove that it is an NP-hard problem, and develop a novel approximation algorithm with performance guarantees. To further support interactive exploration of geospatial data on maps, we propose the Interactive sos (isos) problem, in which we enrich the sos problem with the zooming consistency and panning consistency constraints. The objective of isos is to provide seamless experience for end-users to interactively explore the data by navigating the map. We extend our algorithm for the sos problem to solve the isos problem, and propose a new strategy based on pre-fetching to significantly enhance the efficiency. Finally we have conducted extensive experiments to show the efficiency and scalability of our approach. Last but not least, we study how to partition the geospatial objects into functional regions according to the utilities and spatial distributions. It aims to aggregate similar and adjacent objects into enclosed regions that indicate certain functions. During this process, since the attributes distribution of the geospatial objects are aggregated, some information is lost during this process. We define the information loss to measure how much information is lost when merging two sets of objects. To reduce the possibilities of generated regions, we exploit the existing road networks to limit the boundaries of the separated regions to be roads, since it is the natural partition of cities and people live in these roads-segmented regions and POIs (points of interests) fall in these regions. We formulate this problem as Functional Region Segmentation (frs) problem, and prove that it is an NP-hard problem. We develop a bottom-up greedy algorithm to solve the frs problem, which terminates in limited steps. Results of empirical studies show that our proposed algorithm is able to solve frs problem efficiently and effectively. Doctor of Philosophy (IGS)
- Published
- 2020
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1133. Distributed systems for spatio-textual data streams
- Author
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Chen, Zhida, Cong Gao, and Interdisciplinary Graduate School (IGS)
- Subjects
Engineering::Computer science and engineering [DRNTU] - Abstract
Due to the prosperity of social networks and smart phones, huge amounts of data with both spatial and textual information, e.g., geo-tagged tweets, is generated continuously, which can be modelled as data streams. Such spatio-textual data stream contains valuable information for millions of users with various interests on different keywords and locations. There has been increasing demand for efficiently exploring and processing spatio-textual data streams, which calls for systems that can provide real-time analytical results over the spatio-textual data. Publish/subscribe systems enable efficient and effective information distribution by allowing users to register continuous queries with both spatial and textual constraints. However, most existing publish/subscribe systems are centralized systems, which run on a single machine to process all the incoming data. The explosive growth of data scale and user base has posed challenges to the existing centralized publish/subscribe systems for spatio-textual data streams. To overcome these, we propose a distributed publish/subscribe system, called PS2Stream, which digests a massive spatio-textual data stream and directs the stream to target users with registered interests. Compared with existing systems, PS2Stream achieves a better workload distribution in terms of both minimizing the total amount of workload and balancing the load of workers. To achieve this, we propose a new workload distribution algorithm considering both space and text properties of the data. Additionally, PS2Stream supports dynamic load adjustments to adapt to the change of the workload, which makes PS2Stream adaptive. Extensive empirical evaluation, on commercial cloud computing platform with real data, validates the superiority of our system design and advantages of our techniques on system performance improvement. Publish/subscribe systems provide efficient ways to analyze the spatio-textual data at the tuple level, which return a set of spatio-textual objects satisfying the continuous queries in real time. However, in some scenarios, users are more interested in the higher level knowledge that can be extracted from the data. For instance, a marketing manager wants to know the popularity of some product in different regions, so that he or she can decide whether need to adjust the advertising strategy. A data stream warehouse system (DSWS) has the features of e cient data ingestion and enabling online analytical processing (OLAP) over streaming data. Unfortunately, existing DSWSs are not tailored for spatio-textual data and it requires a significant amount of efforts to address this. We develop a DSWS called STAR (Spatio-Textual Data Stream Warehouse). STAR is a distributed in-memory stream warehouse system, which can provide low-latency and up-to-date analytical results over a fast arriving spatio-textual data stream. STAR facilitates processing of ad-hoc aggregation queries with spatial or textual constraints by implementing a distributed view materialization algorithm. STAR adopts an effective workload partitioning strategy, which well partitions the workload composed of object processing, query processing and view maintaining. Additionally, STAR supports dynamic load adjustments, which make STAR scalable and adaptive. Extensive experiments over real data sets demonstrate the superior performance of STAR over existing systems. Doctor of Philosophy
- Published
- 2019
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1134. Topic Ranger : a tool for topic exploration and analysis of spatio-temporal documents
- Author
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You Lu, Cong Gao, and School of Computer Science and Engineering
- Subjects
Computer science ,Computer science and engineering::Data [Engineering] - Abstract
With the wide-spread usage of social media such as Facebook and Twitter, large amount of data with both spatial and temporal information has become available. Topic modelling has been a useful tool to uncover latent information from such data. This thesis considers a specific type of topic model computational problem called topic-range queries, where the topic model of interest is restricted to the data records that fall within a dynamically specified geographic region and time period. To achieve this purpose, one naive approach is to directly apply a range query to retrieve the data items falling within the specified spatio-temporal range, then derive the topic model from the retrieved data by using a known algorithm such as LDA (Latent Dirichlet Allocation). When dealing with large volume of data, however, the two-step naive approach could each incur substantial amount of time. Novel algorithms for expediting the topic-range queries have been designed, including the fast topic combining algorithm FSS (Fast Set Sampling) which indexes the dataset with a tree, and pre-compute the topic model of the subset of data associated with each node of the tree. To answer a topic-range query, the tree nodes covered by the range query are identified, and the pre-computed topic models associated with these tree nodes are merged to produce an approximate result. Compared to the nave approach, this approximation of topic model substantially can reduce runtime. In the original design of the FSS algorithm, Cube trees are used as the indexing structure to support spatio-temporal range queries. In the literature, however, Range Trees offer a better worst-case query time guarantee for a range query. This master thesis thus considers a new combination of Range Trees and FSS (called Topic Ranger) to support the topic-range queries. The thesis presents the design, implementation of several versions of Topic Ranger for trade-offs between execution time and memory space. It also documents the experiments and comparisons of the execution time and the quality of the resulting approximate topic models against that of the original FSS scheme. Master of Engineering
- Published
- 2019
- Full Text
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1135. Effective and efficient topic mining and exploration from geo-textual data
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Zhao, Kaiqi, Cong Gao, and School of Computer Science and Engineering
- Subjects
Engineering::Computer science and engineering::Data [DRNTU] - Abstract
With the prevalence of online social media (e.g, Facebook, Twitter), location-based services (e.g., Foursquare, Yelp, Flickr), and GPS-enabled devices, a huge number of documents with spatial information are being generated. Such documents are associated with either points of interest (e.g., restaurants) or latitude-longitude coordinates. We call these documents geo-textual documents. Geo-textual documents often contain information that indicates public/individual views and interests. It is of great interest to mine and explore topics from geo-textual documents to help various practical tasks, e.g., business analytics, point-of-interest (POI) recommendation, user recommendation, topic exploration, etc. There are two types of studies on mining topics from geo-textual data — (1) discovering topics of individuals from POI-associated posts (e.g., check-ins); and (2) mining and exploring topics of regions from geo-tagged microblogs. However, both types of studies have several limitations. Firstly, the topics of individuals that are mined from geo-textual data are successfully applied to POI recommendation, location prediction, etc. However, most of the existing methods mine topics from check-in datasets from Foursquare. Because each check-in often consists of limited textual information, and most of the users only shared few check-ins, it is difficult to discover meaningful topics of individuals from the check-in data. Moreover, the existing methods cannot capture topical aspects, e.g., the “environment” of a restaurant, thus failing to tell users why a POI is recommended to the user. Worse still, the existing methods are frequency-based (the more a topic is mentioned, the more likely a user prefers the topic), while ignoring the user’s sentiment. A user may hold negative opinions on some topics even though he/she mentions them many times. Secondly, the existing studies on learning topics of regions only allow users to explore the topics in predefined regions and time spans. A user may want to query topics within a specified region and time span. For example, a social scientist may want to find out breaking events by submitting regions and time spans in an exploratory manner. Some studies propose to learn geographical topic models to uncover latent regions and geographical topics. However, training these models is time consuming. It often takes months to train a model of moderate size (e.g., thousands of topics and thousands of regions) on millions of documents. However, there exists no distributed solution for training geographical topic models. To overcome the limitations in mining topics of individuals, we address two research challenges. First, we propose an approach to associating POIs with geo-tagged microblogs to compose a complementary “check-in” data source for topic mining of individuals. Second, we propose a unified model for learning topical aspects and regions of individuals with consideration of sentiment. The proposed model is able to improve the effectiveness of many downstream applications, e.g., POI recommendation, user recommendation, aspect satisfaction analysis, etc. To overcome the limitations in mining topics of regions, we consider two research problems. First, we develop a framework for exploring topics within a user specified region and time span. The framework can return topics fall in the spatio-temporal query to a user within seconds. Second, to allow efficient training of geographical topic models, we propose a distributed solution that supports learning large geographical topic models with millions of parameters from tens of gigabytes of geo-textual documents within 20 hours on a small cluster of 20 machines. Doctor of Philosophy (SCE)
- Published
- 2018
1136. Selecting the best group of objects in spatial databases and graphs
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Feng, Kaiyu, Cong Gao, and Interdisciplinary Graduate School (IGS)
- Subjects
Engineering::Computer science and engineering::Information systems::Database management [DRNTU] - Abstract
With the prominence of GPS-enabled mobile devices, people can easily acquire their locations and access online services anywhere. The spatial information bridges the gap between the offline world and the online social networks, which leads to the germination of the location-based social networks (LBSNs) and event-based social networks (EBSNs). For instance, users can share their feelings and locations with their friends through LBSNs like Foursquare, and post a review of a restaurant through Yelp. As another example, people can find interesting local events to attend, or organize their own events through Meetup. We refer to the geo-tagged data (e.g. posts, check-ins, reviews, POIs) and the users in the social networks as objects. The availability of large scale social data paves the way to design data-driven approaches for various applications and tasks. We are interested in one type of queries called the group optimization query. Specifically, the group optimization query aims to select a group of objects which together satisfy a specified constraint such that the pre-defined score function of the group is optimized. In this dissertation, we define and investigate novel group optimization queries on spatial data and social networks. Specifically, for group optimization queries on spatial data, we define an axis-aligned rectangular region of a given size as the spatial constraint. Given a size of a rectangle, all the selected spatial objects should be close enough such that they can be covered by a rectangle of the given size. On the other hand, for group optimization queries in social networks, we define a set of attributes as the attribute constraint. All the selected nodes should together cover the specified set of attributes. With the spatial constraint and the attribute constraint, we define and investigate group optimization queries on spatial data and social networks by adopting different functions to measure the quality of the selected objects. We conduct three studies on spatial data, namely best aggregation region detection, bursty region detection and attribute-based similar region detection. We also conduct a study on social networks, namely influential organizers detection. In our study of best aggregation region detection, we propose the best region search (BRS) problem. Specifically, given a set O of spatial objects, the size a * b of a query rectangle, and a submodular monotone aggregate score function, the BRS problem aims at identifying a rectangular region of size a * b such that the aggregate score of the spatial objects inside the region is maximized. We then propose an algorithm to find the exact location of the region with the maximum score. By assuming that slight imprecision to the solution is acceptable, we further propose an algorithm which can find an approximate answer to the BRS problem bounded by a constant. In our study of bursty region detection, we propose a problem which utilizes such spatial object stream to detect and maintain bursty region of a given size in a specified geographic area in real time. We adopt two sliding windows to model the burstiness of a region. To handle spatial streams with high arrival rates, we design several pruning techniques to avoid frequent recomputation. In addition, we propose two approximate algorithms with better efficiency. We also extend the proposed solutions to support continuous detection of top-k bursty regions. In our study of attribute-based similar region detection, we propose the attribute-based similar region search (ASRS) problem, which aims at finding a region of the same size as the query rectangle such that the attribute distance between the two regions is minimized. We propose a grid-based method to address the ASRS problem efficiently. In our study of influential organizers detection, we formulate the influential cover set problem, which aims to select k users who can together cover a set of required skills and their influence is maximized. We adopt the independent cascade model to evaluate the influence of users. We first propose two heuristic greedy algorithms which are very efficient. The third algorithm has an approximation ratio of 2. It guarantees to find a feasible solution if any. Doctor of Philosophy (IGS)
- Published
- 2018
1137. Latent representation models for user sequential mobility and social influence propagation
- Author
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Feng, Shanshan, Cong Gao, Chee Yeow Meng, Interdisciplinary Graduate School (IGS), and Nanyang Environment and Water Research Institute
- Subjects
Engineering::Computer science and engineering [DRNTU] - Abstract
With the increasing popularity of online social media applications, a large amount of data has been generated by users. Based on the user generated data, many research problems have been studied, such as the location-based recommendation and social influence analysis. In this thesis, we investigate the problem of user sequential mobility and the problem of social influence propagation. The main challenge of both problems lies in the difficulty to effectively learn the sequential transition. However, due to the data sparsity, it is hard to model the sequential information by conventional methods. To this end, we resort to the latent representation approach, which is to represent items in a low-dimensional latent space, such that the relations between items are captured by their representations. In addition, based on the social influence propagation in social networks, we study the problem of finding a set of influential users. Doctor of Philosophy (IGS)
- Published
- 2017
1138. Using social media data for urban analysis in Singapore
- Author
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Wee Boon Koh, Cong Gao, and School of Computer Science and Engineering
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Urban analysis ,Regional science ,Social media ,Sociology ,Engineering::Computer science and engineering::Computing methodologies::Document and text processing [DRNTU] ,Engineering::Computer science and engineering::Information systems::Information storage and retrieval [DRNTU] - Abstract
Effective land use planning is essential for countries where land is scarce. In Singapore, land use planning is managed by the Urban Redevelopment Authority (URA). A revised land use plan is released by the URA every four to five years with the goal to create self-sufficient neighbourhoods and reduce commute time between places. Identifying identical land zones can assist city planners to draft out similar development objectives, reducing the time required to produce the land use plan. For business owners, identifying similar land zones can allow them to find the next potential area of expansion that fits their first success case. This work provides an analysis and a framework to the problem of similar urban region query. In particular, the analysis and the proposed query framework investigate the use of urban and social media data to find regions that are topically consistent and exhibits similar demographics. To achieve this, an Urban Region Similarity Analysis System (URSAS) is developed. This work shows that social media data can help to improve the quality of the query result as opposed to only considering urban information. Additionally, this work shows that the proposed query framework can recognize the type of function for a given zone based on urban and social media data. Master of Engineering (SCE)
- Published
- 2017
1139. Spatial keyword querying beyond the single geo-textual object granularity
- Author
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Xin Cao, Cong Gao, School of Computer Engineering, and Centre for Advanced Information Systems
- Subjects
Engineering::Computer science and engineering [DRNTU] - Abstract
With the proliferation of geo-positioning techniques and mobile devices such as smart-phones and tablet computers, the web is increasingly being used by mobile users and accurate user positioning is increasingly available. As a result, a spatial, or geographical web is emerging where contents and users are associated with locations. This leads to the fact that massive amounts of objects are available on the web that possess both a geographical location and a textual description. Such geo-textual objects include stores, tourist attractions, hotels, restaurants, businesses, entertainment services, public transport, etc. The availability of substantial amounts of geo-textual objects gives prominence to spatial keyword queries that target these objects. Such queries exploit both locations and textual descriptions and occur in many types of mobile and traditional web services and applications, e.g., Yellow Pages and Maps services, which greatly facilitate our everyday life. For example, in Google Maps the functionality “search nearby” allows users to retrieve points of interest around a specified location. Spatial keyword querying has attracted significant industrial and academic interests. There exist many proposals on studying spatial keyword queries, which retrieve lists of geo-textual objects that are both textually relevant to the query and satisfy a spatial query predicate. However, most existing work on spatial keyword querying treats the geo-textual objects as independent. This thesis focuses on efficiently processing the spatial keyword queries beyond the single geo-textual object granularity. First, we believe that a relevant result geo-textual object with nearby objects that are also relevant to the query is likely to be preferable over a relevant object without relevant nearby objects. We propose the concept of prestige-based relevance to capture both the textual relevance of an object to a query and the effects of nearby objects. Based on this, a new type of query, the top-k Prestige-based Spatial Keyword (kPSK) query, is proposed that retrieves the top-k geo-textual objects ranked according to both prestige-based relevance and location proximity. Two algorithms are devised to answer kPSK queries. Empirical studies with real-world datasets demonstrate that kPSK queries are more effective in retrieving geo-textual objects than is a previous approach without the consideration of the effects of nearby objects; the experimental results also show that the proposed algorithms are scalable and outperform a baseline approach significantly. Next, proposals for spatial keyword search so far generally focus on finding individual objects rather than finding groups of objects where the objects in a group collectively satisfy the requirements. We define another new type of query named the Spatial Group Keyword (SGK) query, which retrieves a group of geo-textual objects such that the group’s keywords cover the query’s keywords and such that objects are nearest to the query location and have the lowest inter-object distances. Specifically, we study two variants of this problem, both of which are NP-hard. We devise exact solutions as well as approximate solutions with provable approximation bounds to the problems. We present empirical studies that offer insight into the efficiency and accuracy of the solutions. Third, we consider a spatial keyword query over road networks that retrieves routes that are formed by a sequence of geo-textual objects. Identifying a preferable route is an important problem that finds applications in map services. When a user plans a trip within a city, the user may want to find “a most popular route such that it passes by shopping mall, restaurant, and pub, and the travel time to and from my hotel is within 4 hours.” However, no existing algorithms can be used to answer such queries. Motivated by this, we define the Keyword-aware Optimal Route query, denoted by KOR, which finds a route such that it covers a set of user-specified keywords, a specified budget constraint is satisfied, and an objective score of the route is optimal. The problem of answering KOR queries is NP-hard. We first devise an approximation algorithm with provable approximation bounds. Based on this algorithm, a more efficient approximation algorithm is proposed. We also design a greedy approximation algorithm. Results of empirical studies show that all the proposed algorithms are capable of answering KOR queries efficiently. The empirical studies also evaluate the accuracy of the proposed algorithms. DOCTOR OF PHILOSOPHY (SCE)
- Published
- 2014
1140. Aspect-based opinion mining of customer reviews
- Author
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Hai Zhen, Cong Gao, School of Computer Engineering, Centre for Advanced Information Systems, and Chang, Kuiyu
- Subjects
Computer science ,Informatics engineering ,Customer reviews ,Sentiment analysis ,Data science ,Engineering::Computer science and engineering::Computing methodologies::Document and text processing [DRNTU] - Abstract
Online reviews are immensely valuable for customers to make informed decisions on product purchase, hotel booking, etc., and for businesses to improve the quality of their products and services. However, customer reviews grow very rapidly in quantity, while varying largely in quality. It is practically impossible for users to read through all the reviews for good decision-making. Opinion mining, also known as sentiment analysis, has been employed to automatically discover and summarize online reviews. In this thesis, we focus on the problem of aspect-based opinion mining of customer reviews. Our goal is to study and develop computational opinion mining techniques to support users to digest the huge amount of review data. In particular, we study three closely related problems as described below. The first problem deals with extracting aspect terms and opinion words that appear in customer reviews. We propose a generalized corpus statistics association based bootstrapping approach (ABOOT). ABOOT starts with a small list of annotated aspect seeds, and then iteratively extracts a large number of domain-specific aspect terms and opinion words from a given review corpus. ABOOT is able to work properly with only one seed, which can be simply domain word, e.g., "hotel" for hotel reviews. Our second problem focuses on identifying implicit aspects for the opinion words devoid of explicit aspects. Implicit aspects refer to the aspects that do not appear but are implied by opinion words in reviews. In opinion mining, very little work has been done on this problem. We propose a cooccurrence association rule mining method (coARM). coARM first discovers a significant set of association rules from a review corpus, and then it applies the rules to the opinion words devoid of explicit aspects for implicit aspect identification. The third part of this thesis deals with modeling customer reviews with aims at identifying semantic aspects and opinions as well as predicting overall review ratings in a unified framework. We introduce a new supervised joint topic model named supervised joint aspect and opinion model (SJAOM). SJAOM incorporates the overall ratings as supervision data, and simultaneously models the pairwise aspect terms and opinion words in each review. One key advantage of SJAOM is its ability to jointly identify the semantic aspects and opinions that are predictive of the overall ratings of reviews. Experimental results on real-world customer reviews demonstrate the benefits of our proposed methods for opinion mining problems, notably the SJAOM model. DOCTOR OF PHILOSOPHY (SCE)
- Published
- 2014
1141. Exploiting spatial, temporal, and semantic information for point-of-interest recommendation
- Author
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Quan Yuan, Cong Gao, School of Computer Engineering, and Centre for Advanced Information Systems
- Subjects
Management information systems ,Information retrieval ,Information engineering ,Point of interest ,Computer science ,Method engineering ,Engineering informatics ,Engineering::Computer science and engineering::Information systems::Information systems applications [DRNTU] ,Semantic information ,Data science - Abstract
With the prevalence of 3G & 4G services, people can easily share their opinions, moods, and activities with others via smartphones and tablets. As mobile devices are often GPS-enabled, a great quantity of user-generated content (UGC) with geographic locations has been accumulated, such as check-ins in location-based social networks (LBSNs), event-records in event-based social networks (EBSNs), and geo-annotated tweets on Twitter. Besides geographic location, UGC is often associated with timestamp and contains text content. The spatial, temporal and semantic information embedded in geo-annotated UGC can be exploited for a number of appealing applications and research problems. Point-of-interest (POI) recommendation is a representative one, which aims at recommending places that a target user has not visited before. Obviously, POI recommendation can help people explore new places and know their cities better. In addition, merchants can also benefit from it to deliver location-based advertisements and attract more customers. In recent years, a number of POI recommendation methods have been proposed, but most of them neglect contextual information, and make recommendations only based on user-POI check-in matrix. In real life, however, a user's preference to POIs is often influenced by her surroundings or context, such as time, companions, etc. For example, a user may prefer shopping malls to pubs in the afternoon, but may prefer pubs at night. Therefore, contextual information should be an important consideration for POI recommendation. In addition, a user may have specific requirement for recommendations sometimes, which directly reveals the user's preference. Thus, in this dissertation, we exploit the contextual information and requirements to recommend POIs for users. Specifically, we study three recommendation tasks that are relevant to the spatial, temporal, and semantic information of users. First, as human mobility is greatly influenced by time, we believe temporal influence is an important consideration for POI recommendation. We define a new problem, namely, time-aware POI recommendation, which aims to return a list of POIs for a user to visit at a specific time. In addition to temporal influence, human mobility is also influenced by geographic distance, e.g., people often visit their nearby places. To exploit both the temporal and spatial influences, we propose two algorithms, namely, User-based Collaborative Filtering with Temporal preference and smoothing Enhancement + Spatial influence with popularity Enhancement (UTE+SE) and Geographical-Temporal influences Aware Graph+Breadth-first Preference Propagation (GTAG-BPP), both of which are effective in making time-aware POI recommendations. We evaluate the performance of the proposed methods on two datasets, and the results show that the proposed methods outperform the state-of-the-art baselines significantly. Second, we observe that people often participate in activities and visit places together with others, e.g., watching movies with friends, and having dinner with colleagues. Thus, group POI recommendation is a realistic and important task, which aims at recommending POIs for a group of people. However, group recommendation is a challenging task, since group members may have different preferences, and how to balance their preferences is still an open problem. Furthermore, groups are often ad hoc, and the number of history records of a group may be very limited. The cold-start problem caused by ad hoc groups makes group recommendations even harder. To this end, we propose a Latent Dirichlet Allocation (LDA) based COnsensus Model (COM) to simulate the generative process of group activities and make POI recommendations for a group of users. Extensive experimental results on four real-world datasets validate that our model COM achieves superior recommendation accuracy comparing with five baselines. Third, when submitting recommendation requests, users may have clear requirements, e.g., dining or shopping, and the requirements can be formulated as short text. To make use of such information, we define a new task, namely, requirement-aware POI recommendation that generates a list of POIs for a target user based on her specific requirements. In addition, when target time is available, the recommendation results could be also time-aware. However, making time-aware and requirement-aware POI recommendations is non-trivial, as it calls for a model that can take into account the user, time, POI and words factors simultaneously. To solve this problem, we propose two frameworks, namely, a probabilistic Latent Semantic Analysis (pLSA) based model Who+Where+When+What (W4) and a Hierarchical Dirichlet Process (HDP) based model Enhanced W4 (EW^4), to model the complex interactions among the four factors, and make time-aware and requirement-aware POI recommendations. Empirical studies on two real-world datasets demonstrate our proposals outperform state-of-the-art approaches substantially. In summary, in this dissertation, we exploit spatial, temporal, and semantic information to recommend POIs to users, which is a natural but novel extension of exiting proposals on POI recommendation. DOCTOR OF PHILOSOPHY (SCE)
- Published
- 2014
1142. Efficient singapore room rental search with data mining
- Author
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Koh, Fabian, Wee Kim Wee School of Communication and Information, and Cong Gao
- Subjects
Engineering::Computer science and engineering::Information systems::Information storage and retrieval [DRNTU] - Abstract
The author wants to answer the question: how Data Mining techniques can be utilised to improve the efficiency of room rental search? With this, the first objective of this study is to develop a clustering method in the context of Singapore Room Rental listing retrieval, called Relevance-based Clustering. The proposed clustering method adds geographical relationship among the textual relevance search results. The second objective is to develop a Rental Property Search Engine to demonstrate the result of applying Relevance-based Clustering to achieve efficient room rental search in Singapore. The essential part of this process is the ability to extract geographical information from webpages. The author narrows the scope of the study down to Singapore property websites, whereby the geographical information can be easily extracted from the map latitude and longitude information available in all of the major property websites in Singapore. The rental property search engine is custom-coded by the author using Python 2.7 programming language and is being deployed on Google App Engine (GAE) cloud hosting platform. The search engine consists of a property content web crawler that crawls rental section of Singapore property websites, and downloads content from each URL into the Listing table. Next, Data Pre-processing process is used to cleanse and tokenize the downloaded content to create and update into Inverted Index. Processed URLs are recorded into the Done-Process table to prevent duplicate effort. Upon receiving user query input, the query text will be cleansed and tokenized by Query Parsing process before passing over to Scoring and Ranking process to convert into vector form for Cosine Similarity score computation. The scoring will be ranked and the top K number of listings will form the Top K List. The Top K List is used to compute the URL Spherical Distance Matrix and clustering is performed on the URL Spherical Distance Matrix to discover geographical relationship among the top K textual relevance listings. The clustered result is converted into HTML format and returned to the user. The Information Retrieval (IR) effectiveness of the search engine based on K value = 100 has a low average F-Measure of 26%. Whereas, IR effectiveness based on K value = 20 has a better average F-Measure of 78%. Master of Science (Information Studies)
- Published
- 2014
1143. Enhanced subspace clustering
- Author
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Sim, Kelvin Sian Hui., Vivekanand Gopalkrishnan, School of Computer Engineering, Centre for Advanced Information Systems, and Cong Gao
- Subjects
Engineering::Computer science and engineering::Computing methodologies [DRNTU] - Abstract
Subspace clustering overcomes the curse of dimensionality that traditional clustering suffered, by finding groups of objects that are homogeneous in subspaces of the data, instead of the full space. Research on basic subspace clustering over the past decade primary focuses on finding groups of objects that are closed together in subspaces of 2D data. Recently, the proliferation of non-traditional data and the need for higher quality clustering results have shifted the research paradigm to enhanced subspace clustering, which focuses on problems that cannot be handled or solved effectively through basic subspace clustering. The problems of enhanced subspace clustering can be categorized into two main groups, handling non-traditional data and improving clustering results. We give a survey on the enhanced subspace clustering problems, desired properties that these problems sought in their solutions, and the existing solutions. We study three main problems of enhanced subspace clustering on 2D and 3D datasets: mining subspace clusters in noisy data, mining significant subspace clusters and mining semi-supervised subspace clusters. For mining subspace clusters in noisy data, we found several problems of existing approaches, such as mining incomplete and unstable results, lacking the ability to handle 3D data, and mining clusters that are non-maximal and that contain skewed noise. We propose subspace clusters that are maximal and do not contain skewed noise. We also develop algorithms which exploit the anti-monotone property of the clusters to efficiently mine the complete and stable set of results. We show the effectiveness of our solution in mining biologically significant protein clusters in protein-protein interaction data, which is notoriously noisy in nature. For mining significant subspace clusters, we formulate an information theory concept known as correlation information, to measure the significance of the subspace clusters. We propose mining subspace clusters with high correlation information, and we develop an algorithm which uses the concept of rarity to mine significant 3D subspace clusters in a parameter-insensitive way. We show the effectiveness of our solution in finding significant (1) groups of proteins in protein-protein interaction data, (2) clusters of words and documents in word-document data and (3) in classifying an insurance data, where significant clusters are used as rules of the classifier. For mining semi-supervised subspace clusters, we propose actionable subspace clusters, which are semi-supervised subspace clusters that allow incorporation of user's knowledge, and can suggest beneficial actions to the users. We develop algorithms that use augmented Lagrangian multiplier method coupled with frequent itemset mining algorithm to efficiently mine the actionable clusters in a parameter-insensitive way. We show the effectiveness of our solution in finding actionable groups of residues in protein structural data, which are potential binding sites for drug molecules. Lastly, we present a financial data mining application on value investing, and show that our proposed algorithms outperform a famous value investment strategy in 70% of the experiments. Doctor of Philosophy
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- 2012
1144. Safety and immunogenicity of the SARS-CoV-2 ARCoV mRNA vaccine in Chinese adults: a randomised, double-blind, placebo-controlled, phase 1 trial.
- Author
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Chen GL, Li XF, Dai XH, Li N, Cheng ML, Huang Z, Shen J, Ge YH, Shen ZW, Deng YQ, Yang SY, Zhao H, Zhang NN, Zhang YF, Wei L, Wu KQ, Zhu MF, Peng CG, Jiang Q, Cao SC, Li YH, Zhao DH, Wu XH, Ni L, Shen HH, Dong C, Ying B, Sheng GP, Qin CF, Gao HN, and Li LJ
- Subjects
- Adult, Antibodies, Neutralizing, Antibodies, Viral, COVID-19 Vaccines adverse effects, China, Humans, Immunogenicity, Vaccine, Immunoglobulin G, Pandemics prevention & control, Spike Glycoprotein, Coronavirus, Vaccines, Synthetic, mRNA Vaccines, COVID-19 prevention & control, SARS-CoV-2
- Abstract
Background: Safe and effective vaccines are urgently needed to end the COVID-19 pandemic caused by SARS-CoV-2 infection. We aimed to assess the preliminary safety, tolerability, and immunogenicity of an mRNA vaccine ARCoV, which encodes the SARS-CoV-2 spike protein receptor-binding domain (RBD)., Methods: This single centre, double-blind, randomised, placebo-controlled, dose-escalation, phase 1 trial of ARCoV was conducted at Shulan (Hangzhou) hospital in Hangzhou, Zhejiang province, China. Healthy adults aged 18-59 years negative for SARS-CoV-2 infection were enrolled and randomly assigned using block randomisation to receive an intramuscular injection of vaccine or placebo. Vaccine doses were 5 μg, 10 μg, 15 μg, 20 μg, and 25 μg. The first six participants in each block were sentinels and along with the remaining 18 participants, were randomly assigned to groups (5:1). In block 1 sentinels were given the lowest vaccine dose and after a 4-day observation with confirmed safety analyses, the remaining 18 participants in the same dose group proceeded and sentinels in block 2 were given their first administration on a two-dose schedule, 28 days apart. All participants, investigators, and staff doing laboratory analyses were masked to treatment allocation. Humoral responses were assessed by measuring anti-SARS-CoV-2 RBD IgG using a standardised ELISA and neutralising antibodies using pseudovirus-based and live SARS-CoV-2 neutralisation assays. SARS-CoV-2 RBD-specific T-cell responses, including IFN-γ and IL-2 production, were assessed using an enzyme-linked immunospot (ELISpot) assay. The primary outcome for safety was incidence of adverse events or adverse reactions within 60 min, and at days 7, 14, and 28 after each vaccine dose. The secondary safety outcome was abnormal changes detected by laboratory tests at days 1, 4, 7, and 28 after each vaccine dose. For immunogenicity, the secondary outcome was humoral immune responses: titres of neutralising antibodies to live SARS-CoV-2, neutralising antibodies to pseudovirus, and RBD-specific IgG at baseline and 28 days after first vaccination and at days 7, 15, and 28 after second vaccination. The exploratory outcome was SARS-CoV-2-specific T-cell responses at 7 days after the first vaccination and at days 7 and 15 after the second vaccination. This trial is registered with www.chictr.org.cn (ChiCTR2000039212)., Findings: Between Oct 30 and Dec 2, 2020, 230 individuals were screened and 120 eligible participants were randomly assigned to receive five-dose levels of ARCoV or a placebo (20 per group). All participants received the first vaccination and 118 received the second dose. No serious adverse events were reported within 56 days after vaccination and the majority of adverse events were mild or moderate. Fever was the most common systemic adverse reaction (one [5%] of 20 in the 5 μg group, 13 [65%] of 20 in the 10 μg group, 17 [85%] of 20 in the 15 μg group, 19 [95%] of 20 in the 20 μg group, 16 [100%] of 16 in the 25 μg group; p<0·0001). The incidence of grade 3 systemic adverse events were none (0%) of 20 in the 5 μg group, three (15%) of 20 in the 10 μg group, six (30%) of 20 in the 15 μg group, seven (35%) of 20 in the 20 μg group, five (31%) of 16 in the 25 μg group, and none (0%) of 20 in the placebo group (p=0·0013). As expected, the majority of fever resolved in the first 2 days after vaccination for all groups. The incidence of solicited systemic adverse events was similar after administration of ARCoV as a first or second vaccination. Humoral immune responses including anti-RBD IgG and neutralising antibodies increased significantly 7 days after the second dose and peaked between 14 and 28 days thereafter. Specific T-cell response peaked between 7 and 14 days after full vaccination. 15 μg induced the highest titre of neutralising antibodies, which was about twofold more than the antibody titre of convalescent patients with COVID-19., Interpretation: ARCoV was safe and well tolerated at all five doses. The acceptable safety profile, together with the induction of strong humoral and cellular immune responses, support further clinical testing of ARCoV at a large scale., Funding: National Key Research and Development Project of China, Academy of Medical Sciences China, National Natural Science Foundation China, and Chinese Academy of Medical Sciences., Competing Interests: C-FQ and BY are co-inventors on pending patent applications related to the ARCoV mRNA vaccine. LW is an employee of Suzhou Abogen Biosciences. S-YY and ZH are employees of Walvax. All other authors declare no competing interests., (© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license.)
- Published
- 2022
- Full Text
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1145. [Monitoring of plasma concentration of imatinib mesylate in patients with chronic myeloid leukemia].
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Chen C, Wang W, Xu CG, Hou M, Wang LQ, Liu CF, Song Q, and Ji CY
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- Adolescent, Adult, Aged, Antineoplastic Agents blood, Benzamides, Female, Humans, Imatinib Mesylate, Male, Middle Aged, Piperazines blood, Pyrimidines blood, Treatment Outcome, Young Adult, Antineoplastic Agents therapeutic use, Leukemia, Myelogenous, Chronic, BCR-ABL Positive blood, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Piperazines therapeutic use, Pyrimidines therapeutic use
- Abstract
Objective: To analyze the clinical efficacy of imatinib mesylate (IM) for Ph-positive or BCR-ABL positive chronic myeloid leukemia (CML) to couple the trough plasma concentrations (C mins) of IM with clinical responses and adverse events (AEs)., Methods: One hundred and one CML patients received IM therapy, and Cmins of IM were determined in 30 patients., Results: (1) Cumulative complete hematological response (CHR), major cytogenetic response (MCyR), complete cytogenetic response (CCyR) and negative BCR/ABL fusion gene rates were 96.6%, 86.5%, 77.5% and 47.2%, respectively, in CML-CP patients. In accelerated and blastic phases (AP and BC) patients, CHR, MCyR, CCyR and negative BCR-ABL fusion gene rates were 58.3%, 25.0%, 25.0%, 8.3%, respectively. (2) Mean Cmins of IM was significantly higher in the CCyR at 1 year [(1472 +/- 482) microg/L] group than in the non-CCyR at 1 years group [(1067 +/- 373) microg/L] (P < 0.05), and higher in the MMR at 1 year group than in the non-MMR at 1 years group [(1624 +/- 468) microg/L vs (1137 +/- 404) microg/L, P < 0.05]., Conclusion: IM significantly improves cytogenetic and molecular response, event-free survival, and overall survival for patients with Ph-positive CML. The Cmins of IM exerts a significant impact on clinical response (CCyR and MMR at 1 year).
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- 2011
1146. [In vitro activation of bone marrow natural killer T cells of aplastic anemia patients].
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Wang YX, Xu CG, Ran JL, Wu XC, Sun JH, Wang JD, Guo CS, Liu JL, Kong DX, and Dou AX
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- Anemia, Aplastic metabolism, Humans, Interleukin-4 metabolism, Killer Cells, Natural cytology, Bone Marrow metabolism, Natural Killer T-Cells
- Abstract
Objective: To investigate the quantitative and qualitative changes of TCRVα24(+)Vβ11(+) natural killer T (NKT) cells from bone marrow (BM) of aplastic anemia (AA) after in vitro stimulation of α-galactosylceramide (α-Galcer)., Methods: NKT cells in the bone marrow mononuclear cells (BMMNCs) from either AA patients or healthy controls were enumerated with flow cytometry. BMMNCs were cultured in RPMI1640 medium supplemented with either α-Galcer and rhIL-2 or α-Galcer, rhIL-2 and rhG-CSF. The proliferative capacity of NKT cells was determined by NKT cell numbers before and after in vitro culture. Expression of intracellular IFNγ and IL-4 in activated NKT cells was analyzed with flow cytometry., Results: In AA group, the percentage of NKT cells in BMMNCs was (0.19 ± 0.09)%. Addition of rhG-CSF into the α-Galcer/rhIL-2 culture medium resulted in significantly reduced expansion of NKT cells (67.45 ± 29.42-fold vs 79.91 ± 40.56 fold, P < 0.05). Meanwhile, addition of rhG-CSF reduced IFNγ positive NKT cells \[(37.45 ± 7.89)% vs (62.31 ± 14.67)%, P < 0.01\] and increased IL-4 positive NKT cells \[(55.11 ± 12.13)% vs (27.03 ± 9.88)%, P < 0.01\]. In healthy control group, the percentage of NKT cells in BMMNCs was (0.25 ± 0.12)%. Addition of rhG-CSF into the α-Galcer/rhIL-2 culture medium also significantly reduced expansion of NKT cells (97.91 ± 53.22-fold vs 119.58 ± 60.49-fold, P < 0.05), reduced IFNγ positive NKT cells \[(28.65 ± 10.63)% vs (50.87 ± 12.66)%, P < 0.01\], and increased IL-4 positive NKT cells \[(66.53 ± 14.96)% vs (31.11 ± 10.07)%, P < 0.01\]., Conclusion: Compared to those from healthy controls, BMMNCs from AA patiants have a reduced fraction of NKT cells, which possesses a decreased potential to expand in vitro in response to α-Galcer stimulation, and produce more IFNγ(+) NKT1 cells. rhG-CSF, in combination with α-Galcer, confers polarization of NKT cells towards IL-4(+) NKT2 subpopulation.
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- 2010
1147. Rapid detection of BCR-ABL fusion genes using a novel combined LUX primer, in-cell RT-PCR and flow cytometric method.
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Shi Y, Li LZ, Sun JZ, Zhang T, Peng J, and Xu CG
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- Cell Line, Tumor, Humans, In Situ Hybridization, Fluorescence, Proto-Oncogene Mas, Time Factors, DNA Primers genetics, Flow Cytometry methods, Fusion Proteins, bcr-abl analysis, Fusion Proteins, bcr-abl genetics, Light, Reverse Transcriptase Polymerase Chain Reaction methods
- Abstract
Currently, quantitative and semiquantitative assays for minimal residual disease detection include fluorescence in situ hybridisation, multiparameter flow cytometric immunophenotyping and real-time quantitative polymerase chain reaction (RQ-PCR). We have developed a new approach to detect hybrid breakpoint cluster region and Abelson proto-oncogene (BCR-ABL) transcripts inside suspension cells using in situ RT-PCR and light upon extension (LUX) primer, followed by rapid quantitative analysis with flow cytometry. After cellular permeabilization and fixation of single cell suspension, the neoplastic mRNA was reverse transcribed and amplified by PCR with LUX primer. The results demonstrated that a strong positive yellow-green signal was observed in 99-100% cells of K562 cell line, only the red nucleus was detected in NB4 cell line and normal controls. The technique has been utilised to study 12 patients with chronic myeloid leukemia, and the results were compared with those of BCR-ABL fusion mRNA by RT-PCR and BCR-ABL fusion gene of the interphase cells by fluorescence in situ hybridization (FISH). In the five diagnosed patients, 90-98% cells were strongly positive. Four patients, including three patients treated with interferon-alpha and hydroxyurea and one patient treated with imatinib mesylate, had 26-82.5% positive cells. Three patients treated with imatinib mesylate were negative. The in situ RT-PCR results demonstrated complete concordance with the results of I-FISH and RT-PCR. A fluorescence signal was detectable at 1/10(4) cells and became negative below this threshold with flow cytometry. The results of the present study suggest that (1) LUX primers can be used to efficiently detect BCR-ABL fusion mRNA by in-cell RT-PCR; (2) the novel technique is a specific and sensitive way of detecting fusion gene with potential clinical usefulness.
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- 2008
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1148. [Influence of tumor necrosis factor-alpha and interferon-gamma on erythropoietin production and erythropoiesis in cancer patients with anemia].
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Wang W, Zhang MH, Yu Y, and Xu CG
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- Adolescent, Adult, Aged, Anemia etiology, Anemia physiopathology, Erythropoietin biosynthesis, Female, Humans, Male, Middle Aged, Neoplasms complications, Receptors, Transferrin blood, Anemia blood, Erythropoiesis physiology, Erythropoietin blood, Interferon-gamma blood, Tumor Necrosis Factor-alpha metabolism
- Abstract
Objective: To explore impaired erythropoiesis and relative inadequacy of erythropoietin production in the anemic cancer patients and the correlation of tumor necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma) with inadequate erythropoietin (EPO) response and impaired erythropoiesis in cancer patients with anemia., Methods: Fifty adult anemic and 15 non-anemic tumor patients were studied. Serum EPO levels were measured by radioimmunoassay (RIA) and serum soluble transferrin receptor (sTfR). TNF-alpha and IFN-gamma levels by enzyme-linked immunosorbent assay (ELISA). Log transformed EPO and sTfR values were used in statistical analysis. The R correlation analyses were performed., Results: The mean serum immunoreactive erythropoietin level in anemic cancer patients [(23.11 +/- 10.00) IU/L] was not significantly higher than in healthy people (P = 0.053), but significantly lower than in IDA patients with similar degree of anemia [(43.00 +/- 22.00) IU/L, P < 0.01]. Both O/P EPO [0.88 (0.54-1.10)] and O/P sTfR [0.89 (0.57-1.22)] were significantly lower in anemic cancer patients than in controls and in non-anemic cancer patients. There was no significant difference between the latter two groups. Furthermore, the expected inverse linear relation between serum EPO and hemoglobin levels was absent in the anemic cancer patients, and so did the relation between serum sTfR and hemoglobin levels. There was no correlation between O/P EPO and O/P sTfR. The serum levels of both TNF-alpha and IFN-gamma in anemic cancer patients [(25.75 +/- 26.71) ng/L, (50.49 +/- 42.12) ng/L, respectively] were significantly higher than those in healthy controls (both P < 0.01) or in nonanemic cancer patients (both 0.01 < P < 0.05), and so did between non-anemic cancer patients and controls. The serum levels of TNF-alpha were inversely correlated with hemoglobin levels (r = - 0.40, P = 0.004), O/P EPO (r = -0.32, P = 0.025) or O/P sTfR (r = -0.36, P = 0.01); while serum levels of IFN-gamma were inversely correlated with hemoglobin levels (r = -0.36, P = 0.01) or O/P sTfR (r = 0.39, P = 0.006), but not with O/P EPO. Conclusions Anemia of cancer is due to impaired erythropoiesis and relative inadequacy of EPO production. TNF-alpha might inhibit EPO production and erythropoiesis, while IFN-gamma maybe directly inhibit erythropoiesis and be independent of EPO response inadequacy.
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- 2007
1149. [Clinical implications of combined measurement bone marrow T cells intracellular IFNgamma and HLA-DRB1*1501 measurement in predicting the response to immunosuppressive therapy for aplastic anemia].
- Author
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Chen Y, Xu CG, Guo NJ, Huang P, Xiao DJ, Ding BT, and Ge LF
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- Adolescent, Adult, Aged, Anemia, Aplastic blood, Bone Marrow Cells metabolism, CD8-Positive T-Lymphocytes drug effects, CD8-Positive T-Lymphocytes metabolism, Child, Cyclosporine therapeutic use, Female, Flow Cytometry, HLA-DR Antigens genetics, HLA-DRB1 Chains, Humans, Logistic Models, Male, Middle Aged, Polymerase Chain Reaction, Predictive Value of Tests, Treatment Outcome, Anemia, Aplastic drug therapy, Bone Marrow Cells drug effects, HLA-DR Antigens analysis, Immunosuppressive Agents therapeutic use, Interferon-gamma analysis
- Abstract
Objective: To evaluate the clinical implication of combined measurement of bone marrow (BM) T lymphocyte intracellular IFNgamma with HLA-DRB1*1501 in predicting the response to immunosuppressive therapy (IST) in patients with aplastic anemia (AA)., Methods: Enrolled into the present study were 51 idiopathic AA patients treated with cyclosporine A (CsA) based IST. BM CD(8)(+) T lymphocyte intracellular IFNgamma was determined with flow cytometry and HLA-DRB1*1501 detected with PCR-sequence specific primer before treatment. The relationship between laboratory indices and clinical response were investigated and the potential usefulness of parameters in predicting the response to IST for AA was evaluated., Results: These HLA-DRB1*1501 shows sensitivity of 45.7% (16/35) and specificity of 87.5% (14/16) respectively. Intracellular IFNgamma has sensitivity of 94.3% (33/35) and specificity of 62.5% (10/16), respectively. With combination of intracellular IFNgamma with HLA-DRB1*1501, the parallel test increases the sensitivity of 97.1% (34/35) and the negative predictive value of 90.0% (9/10). On the other hand, the serial test improves the specificity and positive predictive value which both achieve 93.7% (15/16). It could be calculated through a logistic regression equation that the probabilities of prediction of four subgroups of patients whose results are both positive reaction, a positive intracellular IFNgamma plus negative HLA-DRB1*1501, a negative intracellular IFNgamma plus positive HLA-DRB1*1501 and both negative reaction are 89.0%, 77.4%, 34.5% and 18.2%, respectively., Conclusions: Combination of BM T cells intracellular IFNgamma stain and HLA-DRB1*1501 phenotype can be a useful predictor for AA patients in immunosuppressive therapy. The patients with both positive results of the two tests may have more possibilities to response to IST. It may have an important implication for the majority of AA patients whose intracellular IFNgamma stain has a positive reaction.
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- 2007
1150. [Preliminary study of multivariable model in predicting response to immunosuppressive therapy in patients with aplastic anemia].
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Chen Y, Xu CG, Guo NJ, Huang P, Xiao DJ, Ding BT, Ge LF, Yu Z, Chang YL, and Zhou YW
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- Adolescent, Adult, Aged, Anemia, Aplastic immunology, Child, Feasibility Studies, Female, HLA-DR Antigens immunology, Humans, Immunosuppressive Agents therapeutic use, Male, Middle Aged, T-Lymphocyte Subsets immunology, T-Lymphocytes immunology, Treatment Outcome, Anemia, Aplastic drug therapy, Immunosuppression Therapy, Models, Statistical
- Abstract
Objective: To evaluate the potential usefulness of a multivariable model in predicting the response to immunosuppressive therapy (IST) in patients with aplastic anemia (AA), and its application to the clinical practice., Methods: PB T cells subpopulation and BM T cells intracellular IFN-gamma and IL-4 were serially analyzed by flow cytometry (FCM) before and during treatment. HLA-DRB1 * 1501 phenotype was analyzed by PCR-SSP. The predictive potentials of different parameter combinations for clinical responsiveness were statistically assessed., Results: In all evaluated parameters, CD8+ cell intracellular IFN-gamma had the relatively best diagnostic value with sensitivity and specificity of 94.3% and 62.5%, and positive and negative predictive value of 84.6% and 83.3% respectively. Positive CD8+ cell intracellular IFN-gamma plus Tc1/Tc2 < 50 could increase the positive predictive value to 92.3%. A multivariable model consisting of absolute neutrophil count (ANC), BM T cell intracellular IFN-gamma, Tc1/Tc2 ratio and HLA-DRB * 1501 phenotype of the patients was finally established., Conclusion: The multivariable model is superior to each of the single parameters in terms of predictive power of IST therapeutic outcome, and its higher accuracy and the clinical application make it potentially useful in practice.
- Published
- 2007
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