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851. Semiempirical versus ab Initio Calculations of Molecular Properties. I. Diamagnetic Susceptibilities and Quadrupole Moments in Some Medium Size Molecules

Author: A . Graovac, Z. B. Maksić, K. Rupnik, and A. Veseli
Abstract: The self-consistent charge molecular orbital (SCC-MO) method was applied to a number of medium size molecules involving atoms exhibiting large differences in electronegativity and possessing one or more lone pairs. The quality of the wave functions thus obtained was applied to a number of medium size molecules involving atoms calculated by a rigorous treatment of the operators x2, y2, and z2• The SCC quadrupole moments can be favourably compared with the ab initio results of Snyder and Basch obtained by the use of a Gaussian double zeta basis set. The present results provide additional justification of the sec method, which has apparent advantages over the methods based on the ZDO approximation. Some difficulties encountered in the treatment of pi-electrons are discussed and suggestions for their remedy are given. The second moments calculated by the application of a simple additivity formula (Z. B. Maksic and J. E. Bloor, Chem. Phys. Lett., 13 (1972) 571; J. Phys. Chem., 77 (1973) 1520) and the related diamagnetic susceptibilities are in very good agreement with the ab initio values.
Published: 1977

852. The Human Atrial Fibrosis Pathway in the Development of Atrial Fibrillation.

Author: Budzikowski, Adam S. and Veseli, Granit
Subjects: *ATRIAL fibrillation treatment, *HEART fibrosis, *ACTININ, *TRANSFORMING growth factors, *MITRAL valve diseases, *MITRAL valve insufficiency, *PATIENTS, *THERAPEUTICS
Published: 2017
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853. Genetic control of the phenobarbital-induced shortening of plasma antipyrine half-lives in man

Author: John G. Page and Elliot S. Veseli
Subjects: Adult, Male, medicine.medical_specialty, Phenobarbital treatment, Alcohol Drinking, Metabolic Clearance Rate, Genetics, Medical, Twins, Pharmacology, Coffee, Single oral dose, Pregnancy, Internal medicine, medicine, Humans, Tea, Chemistry, Smoking, General Medicine, PHENOBARBITAL SODIUM, Articles, Middle Aged, Endocrinology, Phenobarbital, Toxicity, Female, ANTIPYRINE METABOLISM, Identical twins, Drug metabolism, Antipyrine, medicine.drug
Abstract: The mean half-life of antipyrine in the plasma of four sets of identical and four sets of fraternal twins after a single oral dose of 16 mg/kg of antipyrine was 12.7 +/-(SD) 3.3 hr. After 2 wk on sodium phenobarbital (2 mg/kg daily) the half-life of antipyrine in the plasma of these twins was reduced to 8.0 +/-(SD) 1.5 hr. Shortening of the plasma antipyrine half-life occurred in all but one of these 16 normal, adult volunteers, but there was considerable variation in the extent of reduction which ranged from 0 to 69%. Phenobarbital administration decreased individual variations in antipyrine metabolism as indicated by the smaller standard deviation of the plasma antipyrine half-lives after phenobarbital than observed initially and by the narrowed range of variation in plasma antipyrine half-lives from 2.8-fold initially to 1.8-fold after phenobarbital. These results suggest that some inducing agents may be used to minimize individual variations in drug metabolism where such variations create therapeutic problems by exposing patients who slowly metabolize certain drugs to toxicity and other patients who rapidly metabolize some drugs to undertreatment. During the course of phenobarbital administration blood levels were determined. Phenobarbital blood levels correlated neither with the final values for plasma antipyrine half-lives nor with the per cent reduction in plasma antipyrine half-life produced by phenobarbital treatment. There was a direct relationship between initial antipyrine half-lives and the per cent shortening of antipyrine half-life produced by phenobarbital administration: the shorter the initial antipyrine half-life, the less the reduction caused by phenobarbital treatment. Larger intrapair variances in fraternal than in identical twins indicate genetic, rather than environmental, control of phenobarbital-induced alterations in plasma antipyrine half-life.
Published: 1969

854. Large scale test of D0 reconstruction farm

Author: Schellman, H., Albert, M., Bakken, J., Barbaro, L., Breitung, M., Diesburg, M., Fagan, D., Fromm, J., Giacchetti, L., Holmgren, D., Jones, T., Tanya Levshina, Lueking, L., Mandrichenko, I., Mayola, S., Moibenko, A., Pasetes, R., Petravick, D., Schweitzer, M., Shepelak, K., Terekhov, I., Trumbo, J., Veseli, S., Vranicar, M., Wellner, R., White, S., and White, V.

855. CMS expression of interest in the SLHC

Author: Nash, J., Acosta, D., Smith, W., Hall, G., Baden, D., Dallavalle, M., Bayatian, G. L., Chatrchyan, S., Hmayakyan, G., Sirunyan, A. M., Adam, W., Bergauer, T., Dragicevic, M., Ero, J., Friedl, M., Fruehwirth, R., Ghete, V., Glaser, P., Hrubec, J., Jeitler, M., Krammer, M., Magrans, I., Mikulec, I., Mitaroff, W., Noebauer, T., Pernicka, M., Porth, P., Rohringer, H., Strauss, J., Taurok, A., Waltenberger, W., Walzel, G., Widl, E., Wulz, C. -E, Fedorov, A., Korzhik, M., Missevitch, O., Zuyeuski, R., Chekhovsky, V., Dvornikov, O., Emeliantchik, I., Litomin, A., Mossolov, V., Shumeiko, N., Solin, A., Stefanovitch, R., Suarez Gonzalez, J., Tikhonov, A., Petrov, V., D Hondt, J., Weirdt, S., Goorens, R., Heyninck, J., Lowette, S., Tavernier, S., Doninck, Walter, Lancker, L., Bouhali, O., Clerbaux, B., Lentdecker, G., Dewulf, J. P., Mahmoud, T., Marage, P. E., Neukermans, L., Sundararajan, V., Vander Velde, C., Vanlaer, P., Wickens, J., Assouak, S., Bonnet, J. L., Bruno, G., Caudron, J., Callatay, B., Favereau Jeneret, J., Visscher, Simon, Delaere, C., Demin, P., Favart, D., Feltrin, E., Forton, E., Gregoire, G., Kalinin, S., Kcira, D., Keutgen, T., Leibenguth, G., Lemaitre, V., Liu, Y., Michotte, D., Militaru, O., Ninane, A., Ovyn, S., Pierzchala, T., Piotrzkowski, K., Roberfroid, V., Rouby, X., Teyssier, D., Aa, O., Vander Donckt, M., Daubie, E., Herquet, P., Mollet, A., Romeyer, A., Beaumont, W., Cardaci, M., Langhe, E., Wolf, E. A., Rurua, L., Souza, M. H. G., Oguri, V., Santoro, A., Sznajder, A., Vaz, M., Gregores, E. M., Novaes, S. F., Anguelov, T., Antchev, G., Atanasov, I., Damgov, J., Darmenov, N., Dimitrov, L., Genchev, V., Iaydjiev, P., Panev, B., Piperov, Stefan, Stoykova, S., Sultanov, G., Vankov, I., Dimitrov, A., Kozhuharov, V., Litov, L., Makariev, M., Marinov, A., Marinova, E., Markov, S., Mateev, M., Pavlov, B., Petkov, P., Sabev, C., Stoynev, S., Toteva, Z., Verguilov, V., Chen, G. M., Chen, H. S., He, K. L., Jiang, C. H., Li, W. G., Liu, H. M., Meng, X., Shen, X. Y., Sun, H. S., Yang, M., Zhao, W. R., Zhuang, H. L., Ban, Y., Cai, J., Liu, S., Qian, S. J., Yang, Z. C., Ye, Y. L., Ying, J., Wu, J., Zhang, Z. P., Godinovic, N., Puljak, I., Soric, I., Antunovic, Z., Dzelalija, M., Marasovic, K., Brigljevic, V., Ferencek, D., Kadija, K., Morovic, S., Planinic, M., Nicolaou, C., Papadakis, A., Razis, P. A., Tsiakkouri, D., Hektor, A., Kadastik, M., Kannike, K., Lippmaa, E., Muntel, M., Raidal, M., Aarnio, P. A., Czellar, S., Haeggstroem, E., Heikkinen, A., Harkonen, J., Karimaki, V., Kinnunen, R., Lampen, T., Lassila-Perini, K., Lehti, S., Linden, T., Luukka, P. R., Michal, S., Maenpaa, T., Nysten, J., Stettler, M., Tuominen, E., Tuominiemi, J., Wendland, L., Tuuva, T., Guillaud, J. P., Nedelec, P., Sillou, D., Anfreville, M., Beauceron, S., Bougamont, E., Bredy, P., Chipaux, R., Dejardin, M., Denegri, D., Descamps, J., Fabbro, B., Faure, J. L., Ganjour, S., Gentit, F. X., Givernaud, A., Gras, P., Hamel Monchenault, G., Jarry, P., Kircher, F., Lemaire, M. C., Levesy, B., Locci, E., Lottin, J. P., Mandjavidze, I., Mur, M., Pasquetto, E., Payn, A., Rander, J., Reymond, J. M., Rondeaux, F., Rosowsky, A., Sun, Z. H., Verrecchia, P., Baffioni, S., Beaudette, F., Bercher, M., Berthon, U., Bimbot, S., Bourotte, J., Busson, P., Cerutti, M., Chamont, D., Charlot, C., Collard, C., Decotigny, D., Delmeire, E., Dobrzynski, L., Gaillac, A. M., Geerebaert, Y., Gilly, J., Haguenauer, M., Karar, A., Mathieu, A., Milleret, G., Mine, P., Paganini, P., Romanteau, T., Semeniouk, I., Sirois, Y., Berst, J. D., Brom, J. M., Didierjean, F., Drouhin, F., Fontaine, J. C., Goerlach, U., Graehling, P., Gross, L., Houchu, L., Juillot, P., Lounis, A., Maazouzi, C., Mangeol, D., Olivetto, C., Todorov, T., Hove, P., Vintache, D., Ageron, M., Agram, J. L., Baulieu, G., Bedjidian, M., Blaha, J., Bonnevaux, A., Boudoul, G., Chabanat, E., Combaret, C., Contardo, D., Della Negra, R., Depasse, P., Dupasquier, T., El Mamouni, H., Estre, N., Fay, J., Gascon, S., Giraud, N., Girerd, C., Haroutunian, R., Ianigro, J. C., Ille, B., Lethuillier, M., Lumb, N., Mathez, H., Maurelli, G., Mirabito, L., Perries, S., Ravat, O., Kvatadze, R., Roinishvili, V., Adolphi, R., Brauer, R., Braunschweig, W., Esser, H., Feld, L., Heister, A., Karpinski, W., Klein, K., Kukulies, C., Olzem, J., Ostapchuk, A., Pandoulas, D., Pierschel, G., Raupach, F., Schael, S., Schwering, G., Thomas, M., Weber, M., Wittmer, B., Wlochal, M., Adolf, A., Biallass, Philipp A., Bontenackels, M., Erdmann, M., Fesefeldt, H., Hebbeker, T., Hermann, S., Hilgers, G., Hoepfner, K., Hof, C., Kappler, S., Kirsch, M., Lanske, D., Philipps, B., Reithler, H., Rommerskirchen, T., Sowa, M., Szczesny, H., Tonutti, M., Tsigenov, O., Beissel, F., Davids, M., Duda, M., Flugge, G., Franke, T., Giffels, M., Hermanns, T., Heydhausen, D., Kasselmann, S., Kaussen, G., Kress, T., Linn, A., Nowack, A., Poettgens, M., Pooth, O., Stahl, A., Tornier, D., Flossdorf, A., Hegner, B., Joachim Mnich, Rosemann, C., Flucke, G., Holm, U., Klanner, R., Pein, U., Schirm, N., Schleper, P., Steinbruck, G., Stoye, M., Staa, R., Wick, K., Blum, P., Buege, V., Boer, W., Dirkes, G., Fahrer, M., Feindt, M., Felzmann, U., Fernandez Menendez, J., Frey, M., Furgeri, A., Hartmann, F., Heier, S., Jung, C., Ledermann, B., Muller, Th, Niegel, M., Oehler, A., Ortega Gomez, T., Piasecki, C., Quast, G., Rabbertz, K., Saout, C., Scheurer, A., Schieferdecker, D., Schmidt, A., Simonis, H. J., Theel, A., Vest, A., Weiler, T., Weiser, C., Weng, J., Zhukov, V., Karapostoli, G., Katsas, P., Kreuzer, P., Panagiotou, A., Papadimitropoulos, C., Anagnostou, G., Barone, M., Geralis, T., Kalfas, C., Koimas, A., Kyriakis, A., Kyriazopoulou, S., Loukas, D., Markou, A., Markou, C., Mavrommatis, C., Theofilatos, K., Vermisoglou, G., Zachariadou, A., Aslanoglou, X., Evangelou, I., Kokkas, P., Manthos, N., Papadopoulos, I., Sidiropoulos, G., Triantis, F. A., Bencze, G., Boldizsar, L., Hajdu, C., Horvath, D., Laszlo, A., Odor, G., Sikler, F., Toth, N., Vesztergombi, G., Zalan, P., Molnar, J., Beni, N., Kapusi, A., Marian, G., Raics, P., Szabo, Z., Szillasi, Z., Zilizi, G., Bawa, H. S., Beri, S. B., Bhandari, V., Bhatnagar, V., Kaur, M., Kaur, R., Kohli, J. M., Kumar, A., Singh, J. B., Bhardwaj, A., Bhattacharya, S., Chatterji, S., Chauhan, S., Choudhary, B. C., Gupta, P., Jha, M., Ranjan, K., Shivpuri, R. K., Srivastava, A. K., Borkar, S., Dixit, M., Ghodgaonkar, M., Kataria, S. K., Lalwani, S. K., Mishra, V., Mohanty, A. K., Topkar, A., Aziz, T., Banerjee, S., Bose, S., Cheere, N., Chendvankar, S., Deshpande, P. V., Guchait, M., Gurtu, A., Maity, M., Majumder, G., Mazumdar, K., Nayak, A., Patil, M. R., Sharma, S., Sudhakar, K., Tonwar, S. C., Acharya, Bannanje Sripath, Bheesette, S., Dugad, S., Kalmani, S. D., Lakkireddi, V. R., Mondal, N. K., Panyam, N., Verma, P., Arabgol, M., Arfaei, H., Hashemi, M., Mohammadi, M., Mohammadi Najafabadi, M., Moshaii, A., Paktinat Mehdiabadi, S., Grunewald, M., Abbrescia, M., Barbone, L., Colaleo, A., Creanza, D., Filippis, N., Palma, M., Donvito, G., Fiore, L., Giordano, D., Iaselli, G., Loddo, F., Maggi, G., Maggi, M., Manna, N., Marangelli, B., Mennea, M. S., My, S., Natali, S., Nuzzo, S., Pugliese, G., Radicci, V., Ranieri, A., Romano, F., Selvaggi, G., Silvestris, L., Tempesta, P., Trentadue, R., Zito, G., Abbiendi, G., Bacchi, W., Benvenuti, A., Bonacorsi, D., Braibant-Giacomelli, S., Capiluppi, P., Cavallo, F. R., Ciocca, C., Codispoti, G., D Antone, I., Dallavalle, G. M., Fabbri, F., Fanfani, A., Giacomelli, P., Grandi, C., Guerzoni, M., Guiducci, L., Marcellini, S., Masetti, G., Montanari, A., Navarria, F., Odorici, F., Perrotta, A., Rossi, A., Rovelli, T., Siroli, G., Travaglini, R., Albergo, S., Chiorboli, M., Costa, S., Galanti, M., Gatto Rotondo, G., Noto, F., Potenza, R., Russo, G., Tricomi, A., Tuve, C., Bocci, A., Ciraolo, G., Ciulli, V., Civinini, C., D Alessandro, R., Focardi, E., Genta, C., Lenzi, P., Macchiolo, A., Magini, N., Manolescu, F., Marchettini, C., Masetti, L., Mersi, S., Meschini, M., Paoletti, S., Parrini, G., Ranieri, R., Sani, M., Fabbricatore, P., Farinon, S., Greco, Mario, Cattaneo, G., Min, A., Dominoni, M., Farina, F. M., Ferri, F., Ghezzi, A., Govoni, P., Leporini, R., Magni, S., Malberti, M., Malvezzi, S., Marelli, S., Menasce, D., Moroni, L., Negri, P., Paganoni, M., Pedrini, D., Pullia, A., Ragazzi, S., Redaelli, Nicola Giuseppe, Rovelli, C., Rovere, M., Sala, L., Sala, S., Salerno, R., Tabarelli Fatis, T., Vigano, S., Comunale, G., Fabozzi, F., Lomidze, D., Mele, S., Paolucci, P., Piccolo, D., Polese, G., Sciacca, C., Azzi, P., Bacchetta, N., Bellato, M., Benettoni, M., Bisello, D., Borsato, E., Candelori, A., Checchia, P., Conti, E., Mattia, M., Dorigo, T., Drollinger, V., Fanzago, F., Gasparini, F., Gasparini, U., Giarin, M., Giubilato, P., Gonella, F., Kaminskiy, A., Karaevskii, S., Khomenkov, V., Lacaprara, S., Lippi, I., Loreti, M., Lytovchenko, O., Mazzucato, M., Meneguzzo, A. T., Michelotto, M., Montecassiano, F., Nigro, M., Passaseo, M., Pegoraro, M., Rampazzo, G., Ronchese, P., Torassa, E., Ventura, S., Zanetti, M., Zotto, P., Zumerle, G., Belli, G., Berzano, U., Vecchi, C., Grelli, A., Guida, R., Necchi, M. M., Ratti, S. P., Riccardi, C., Sani, G., Torre, P., Vitulo, P., Ambroglini, F., Babucci, E., Benedetti, D., Biasini, M., Bilei, G. M., Caponeri, B., Checcucci, B., Fano, L., Lariccia, P., Mantovani, G., Passeri, D., Pioppi, M., Placidi, P., Postolache, V., Ricci, D., Santocchia, A., Servoli, L., Spiga, D., Azzurri, P., Bagliesi, Giuseppe, Basti, A., Benucci, L., Bernardini, J., Boccali, T., Borrello, L., Bosi, F., Calzolari, F., Castaldi, R., Cerri, C., Cucoanes, A. S., D Alfonso, M., Orso, R., Dutta, S., Foa, L., Gennai, S., Giammanco, A., Giassi, A., Kartashov, D., Ligabue, F., Linari, S., Lomtadze, T., Lungu, G. A., Mangano, B., Martinelli, G., Massa, M., Messineo, A., Moggi, A., Palla, F., Palmonari, F., Petrucciani, G., Raffaelli, F., Rizzi, A., Sanguinetti, G., Segneri, G., Sentenac, D., Serban, A. T., Sguazzoni, G., Slav, A., Spagnolo, P., Tenchini, R., Tonelli, G., Venturi, A., Verdini, P. G., Vos, M., Baccaro, S., Barone, L., Bartoloni, A., Cavallari, F., Costantini, S., Dafinei, I., Del Re, D., Diemoz, M., Gargiulo, C., Longo, E., Meridiani, P., Organtini, G., Rahatlou, S., Accomando, E., Arneodo, M., Ballestrero, A., Bellan, R., Biino, C., Bolognesi, S., Cartiglia, N., Cerminara, G., Cordero, M., Costa, M., Dellacasa, G., Demaria, N., Maina, E., Mariotti, C., Maselli, S., Mereu, P., Migliore, E., Monaco, V., Nervo, M., Obertino, M. M., Pastrone, N., Petrillo, G., Romero, A., Ruspa, M., Sacchi, R., Staiano, A., Trapani, P. P., Belforte, S., Cossutti, F., Della Ricca, G., Penzo, A., Cho, K., Ham, S. W., Han, D., Kim, D. H., Kim, G. N., Kim, J. C., Kim, W. Y., Lee, M. W., Oh, S. K., Park, W. H., Ro, S. R., Son, D. C., Suh, J. S., Kim, J. Y., Jung, S. Y., Rhee, J. T., Hong, B. S., Hong, S. J., Lee, K. S., Park, I., Park, S. K., Sim, K. S., Won, E., Kim, S. B., Carrillo Moreno, S., Castilla Valdez, H., Sanchez Hernandez, A., Salazar Ibarguen, H. A., Morelos Pineda, Antonio, Gray, R. N. C., Krofcheck, D., Bernardino Rodrigues, N., Butler, Philip H., Williams, J. C., Aftab, Z., Ahmad, M., Ahmad, U., Ahmed, I., Alam Jan, J., Asghar, M. I., Asghar, S., Hafeez, M., Hoorani, H. R., Ibrahim, M., Iftikhar, M., Khan, M. S., Qaiser, N., Rehman, I., Solaija, T., Toor, S., Blocki, J., Cyz, A., Gladysz-Dziadus, E., Mikocki, S., Turnau, J., Wlodarczyk, Z., Zychowski, P., Bunkowski, K., Czyrkowski, H., Dabrowski, R., Dominik, W., Doroba, K., Kalinowski, A., Konecki, M., Krolikowski, J., Kudla, Ignacy M., Pietrusinski, M., Pozniak, K., Zabolotny, W., Zych, P., Bluj, M., Gokieli, R., Goscilo, L., Gorski, M., Nawrocki, K., Traczyk, P., Wrochna, G., Zalewski, P., Alemany-Fernandez, R., Almeida, C., Almeida, N., Araujo Trindade, A., Bordalo, P., Da Silva Rodrigues, P., Husejko, M., Jain, A., Kazana, M., Musella, P., Ramos, S., Rasteiro Da Silva, J., Ribeiro, P. Q., Santos, M., Semiao, J., Silva, P., Teixeira, I., Teixeira, J. P., Varela, J., Afanasiev, S., Babich, K., Belotelov, I., Elsha, V., Ershov, Y., Filozova, I., Golunov, A., Golutvin, I., Gorbounov, N., Gramenitski, I., Kalagin, V., Kamenev, A., Karjavin, V., Khabarov, S., Khabarov, V., Kiryushin, Y., Konoplyanikov, V., Korenkov, V., Kozlov, G., Kurenkov, A., Lanev, A., Lysiakov, V., Malakhov, A., Melnitchenko, I., Mitsyn, V. V., Moisenz, K., Moisenz, P., Movchan, S., Nikonov, E., Oleynik, D., Palichik, V., Perelygin, V., Petrosyan, A., Rogalev, E., Samsonov, V., Savina, M., Semenov, R., Shmatov, S., Shulha, S., Smirnov, V., Smolin, D., Tcheremoukhine, A., Teryaev, O., Tikhonenko, E., Vassiliev, S., Vishnevskiy, A., Volodko, A., Zamiatin, N., Zarubin, A., Zarubin, P., Zubarev, E., Bondar, N., Golovtsov, V., Golyash, A., Ivanov, Y., Kim, V., Kozlov, V., Lebedev, V., Makarenkov, G., Orishchin, E., Shevel, A., Sknar, V., Smirnov, I., Sulimov, V., Tarakanov, V., Uvarov, L., Velichko, G., Volkov, S., Vorobyev, A., Andreev, Yu, Anisimov, A., Gninenko, S., Golubev, N., Gorbunov, D., Kirsanov, M., Kovzelev, A., Krasnikov, N., Matveev, V., Pashenkov, A., Postoev, V. E., Sadovski, A., Solovey, A., Soloviev, D., Stepanova, L., Toropin, A., Gavrilov, V., Ilina, N., Kaftanov, V., Kiselevich, I., Kolosov, V., Kossov, M., Krokhotin, A., Kuleshov, S., Oulianov, A., Safronov, G., Semenov, S., Stolin, V., Vlasov, E., Zaytsev, V., Fomenko, A. M., Konovalova, N., Lebedev, A. I., Lvova, N., Rusakov, S. V., Terkulov, A., Boos, E., Dubinin, M., Dudko, L., Ershov, A., Gribushin, A., Ilyin, V., Klyukhin, V., Kodolova, Olga, Lokhtin, I., Petrushanko, S., Sarycheva, L., Savrin, V., Sherstnev, A., Snigirev, A., Teplov, K., Vardanyan, I., Abramov, V., Azhguirei, I., Bitioukov, S., Datsko, K., Filine, A., Goncharov, P., Grishin, V., Inyakin, A., Kachanov, V., Khmelnikov, A., Konstantinov, D., Korablev, A., Krychkine, V., Levine, A., Lobov, I., Pikalov, V., Ryutin, R., Slabospitsky, S., Sourkov, A., Sytine, A., Tourtchanovitch, L., Troshin, S., Tyurin, N., Uzunian, A., Volkov, A., Zelepoukine, S., Adzic, P., Krpic, D., Maletic, D., Milenovic, P., Puzovic, J., Smiljkovic, N., Zupan, M., Aguilar-Benitez, M., Alberdi, J., Alcaraz Maestre, J., Aldaya Martin, M., Arce, P., Barcala, J. M., Burgos Lazaro, C., Caballero Bejar, J., Calvo, E., Cardenas Montes, M., Cerrada, M., Chamizo Llatas, M., Colino, N., Daniel, M., La Cruz, B., Fernandez Bedoya, C., Ferrando, A., Fouz, M. C., Garcia-Abia, Pablo, Hernandez, J. M., Josa, M. I., Luque, J. M., Marin, J., Merino, G., Molinero, A., Navarrete, J. J., Oller, J. C., Perez Calle, E., Romero, L., Salicio, J., Villanueva Munoz, C., Willmott, C., Yuste, C., Albajar, C., Troconiz, J. F., Fernandez, M., Jimenez, I., Teixeira, R. F., Cuevas, J., Lopez, J. M., Naves Sordo, H., Vizan Garcia, J. M., Calderon, A., Cano Fernandez, D., Diaz Merino, I., Garcia Moral, L. A., Gomez, G., Gonzalez Caballero, I., Gonzalez Sanchez, J., Lopez Virto, A., Marco, J., Marco, R., Martinez Rivero, C., Martinez Ruiz Del Arbol, P., Matorras, F., Patino Revuelta, A., Rodrigo, T., Rodriguez Gonzalez, D., Ruiz Jimeno, Alberto, Sobron Sanudo, M., Vila, I., Vilar Cortabitarte, R., Abbaneo, D., Abbas, S. M., Agostino, L., Akhtar, S., Amapane, N., Araujo Meleiro, B., Argiro, S., Ashby, S., Aspell, P., Auffray, E., Axer, M., Ball, A., Bangert, N., Barney, D., Bernet, C., Bialas, W., Bloch, C., Bloch, P., Bonacini, S., Bosteels, M., Boyer, V., Branson, A., Brett, A. M., Breuker, H., Bruneliere, R., Buchmuller, O., Campi, D., Camporesi, T., Cano, E., Carrone, E., Cattai, A., Chierici, R., Christiansen, T., Cittolin, S., Corrin, E., Corvo, M., Cucciarelli, S., Cure, B., D Enterria, David G., Roeck, A., Delikaris, D., Della Negra, M., Dierlamm, A., Elliott-Peisert, A., Eppard, M., Foeth, H., Folch, R., Fratianni, S., Funk, W., Gaddi, A., Gastal, M., Gayde, J. C., Gerwig, H., Gill, K., Giolo-Nicollerat, A. A., Glege, F., Gomez-Reino Garrido, R., Goudard, R., Gutleber, J., Hansen, M., Hartert, J., Herve, Alain, Hoffmann, H. F., Honma, A., Huhtinen, M., Iles, G., Innocente, V., Jank, W., Janot, P., Kloukinas, K., Lasseur, C., Lebeau, M., Lecoq, P., Leonidopoulos, C., Letheren, M., Ljuslin, C., Loos, R., Magazzu, G., Malgeri, L., Mannelli, M., Marchioro, A., Meijers, F., Meschi, E., Moser, R., Mulders, M., Ofierzynski, R. A., Oh, A., Olbrechts, P., Onnela, A., Orsini, L., Pal, I., Papotti, G., Paramatti, R., Passardi, G., Perea Solano, B., Perinic, G., Petagna, P., Petrilli, A., Pfeiffer, A., Pimia, M., Pintus, R., Postema, H., Principe, R., Puerta Pelayo, J., Racz, A., Rehn, J., Reynaud, S., Risoldi, M., Rodrigues Simoes Moreira, P., Rolandi, G., Rosinsky, P., Rumerio, P., Sakulin, H., Samyn, D., Schilling, F. P., Schwick, C., Schafer, C., Segoni, I., Sharma, A., Siegrist, P., Sinanis, N., Sphicas, P., Spiropulu, M., Szoncso, F., Teller, O., Treille, D., Troska, J., Tsesmelis, E., Tsirigkas, D., Tsirou, A., Ungaro, D., Vasey, F., Vazquez Acosta, Monica Luisa, Veillet, L., Vichoudis, P., Wertelaers, P., Wijnant, A., Wilhelmsson, M., Willers, I. M., Bertl, Wilhelm H., Deiters, K., Erdmann, W., Gabathuler, K., Heising, S., Horisberger, R., Ingram, Q., Kaestli, H. C., Kotlinski, D., Konig, S., Renker, D., Rohe, T., Spira, M., Betev, B., Davatz, G., Dissertori, G., Dittmar, M., Djambazov, L., Ehlers, J., Eichler, R., Faber, G., Freudenreich, K., Fuchs, J. F., Grab, C., Holzner, A., Ingenito, P., Langenegger, U., Lecomte, P., Leshev, G., Lister, A., Luckey, David, Lustermann, W., Maillefaud, J. D., Moortgat, F., Nardulli, A., Nessi-Tedaldi, F., Pape, L., Pauss, F., Rykaczewski, H., Roser, U., Schinzel, D., Starodumov, A., Stockli, F., Suter, H., Tauscher, L., Trub, P., Gunten, H. P., Wensveen, M., Alagoz, E., Amsler, Claude, Chiochia, V., Hoermann, C., Prokofiev, Kirill, Regenfus, Christian, Robmann, P., Speer, T., Steiner, S., Wilke, L., Blyth, S., Chang, Y. H., Chen, E. A., Go, A., Hung, C. C., Kuo, C. M., Lin, W., Chang, P., Chao, Y., Chen, K. F., Gao, Z., Hsiung, Y., Lei, Y. J., Schumann, J., Shiu, J. G., Ueno, K., Velikzhanin, Y., Yeh, P., Aydin, S., Bakirci, M. N., Cerci, S., Dumanoglu, I., Erturk, S., Esen, S., Eskut, E., Kayis Topaksu, A., Kurt, P., Ozkurt, H., Polatoz, A., Sogut, K., Topakli, H., Vergili, M., Yetkin, T., Onengut, G., Gamsizkan, H., Ozkan, C., Sekmen, S., Serin-Zeyrek, M., Sever, R., Yazgan, E., Zeyrek, M., Cakir, A., Cankocak, K., Deliomeroglu, M., Demir, D., Dindar, K., Gulmez, Erhan, Isiksal, E., Kaya, M., Kaya, O., Ozkorucuklu, S., Sonmez, N., Grinev, B., Lyubynskiy, V., Senchyshyn, V., Levchuk, L., Sorokin, P., Bailey, D. S., Barrass, T., Brooke, J. J., Croft, R., Cussans, D., Evans, D., Frazier, R., Grant, N., Heath, G. P., Heath, H. F., Huckvale, B., Lynch, C., Mackay, C. K., Metson, S., Newbold, D. M., Smith, V. J., Tapper, R. J., Baird, S. A., Bell, Kenneth Watson, Brown, Robert M., Cockerill, D. J. A., Coughlan, J. A., Flower, P. S., Francis, V. B., French, M., Greenhalgh, R. Justin, Halsall, R., Hill, J., Jones, L., Kennedy, B. W., Lintern, L., Lodge, A. B., Maddox, J., Morrissey, Q., Murray, P., Pearson, M., Quinton, S., Salisbury, J., Shah, A., Shepherd-Themistocleous, C., Smith, B., Sproston, M., Stephenson, R., Taghavirad, S., Tomalin, I. R., Williams, J. H., Arteche, F., Bainbridge, R., Barber, G., Barrillon, P., Beuselinck, R., Blekman, F., Britton, D., Colling, D., Daskalakis, G., Dewhirst, G., Dris, Stefanos, Foudas, C., Fulcher, J., Greder, S., Jones, J., Leaver, J., Macevoy, B. C., Maroney, O., Nikitenko, A., Papageorgiou, A., Raymond, D. M., Ryan, M. J., Seez, C., Sharp, P., Takahashi, M., Timlin, C., Virdee, T., Wakefield, S., Wingham, M., Zabi, A., Zhang, Y., Zorba, O., Da Via, C., Goitom, I., Hobson, P. R., Kyberd, P., Munro, C., Nebrensky, J., Reid, I., Sharif, O., Taylor, R., Teodorescu, L., Watts, S. J., Yaselli, I., Hazen, E., Heering, A. H., Lazic, D., Machado, E., Osborne, D., Rohlf, J., Sulak, L., Varela Rodriguez, F., Wu, S., Cutts, D., Hooper, R., Landsberg, G., Partridge, Richard, Vanini, S., Breedon, R., Case, M., Chertok, M., Conway, J., Cox, P. T., Erbacher, R., Gunion, J., Holbrook, B., Ko, W., Lander, R., Pellett, David E., Smith, J., Soha, A., Tripathi, M., Vogt, R., Andreev, V., Arisaka, K., Cline, D., Cousins, R., Erhan, S., Felcini, M., Hauser, J., Ignatenko, M., Lisowski, B., Matlock, D., Matthey, C., Mohr, B., Mumford, J., Otwinowski, S., Rakness, G., Schlein, P., Shi, Y., Tucker, J., Valuev, V., Wallny, R., Wang, H. G., Yang, X., Zheng, Y., Clare, R., Fortin, D., Futyan, D., Gary, John William, Giunta, Marina, Hanson, G., Jeng, G. Y., Kao, S. C., Liu, H., Pasztor, G., Satpathy, A., Shen, B. C., Stringer, R., Sytnik, V., Wilken, R., Zer-Zion, D., Branson, J. G., Dusinberre Sudano, Elizabeth Jane, Letts, J., Martin, T., Mojaver, M., Paar, H. P., Pi, H., Pieri, M., Rana, A., Sharma, V., White, A., Wuerthwein, Frank K., Affolder, A., Campagnari, C., Hill, C., Incandela, J., Kyre, S., Lamb, J., Richman, J., Stuart, D., White, D., Albert, J., Bornheim, A., Bunn, J., Chen, J., Denis, G., Galvez, P., Gataullin, M., Legrand, I., Litvine, Vladimir A., Ma, Y., Nae, D., Newman, H. B., Ravot, S., Shevchenko, S., Singh, S., Steenberg, C., Su, X., Timciuc, V., Lingen, F., Veverka, J., Voicu, B. R., Weinstein, A., Wilkinson, R., Yang, Y., Zhang, L. Y., Zhu, K., Zhu, R. Y., Ferguson, T., Paulini, M., Russ, J., Terentyev, N., Vogel, H., Vorobiev, I., Cumalat, J. P., Ford, William T., Johnson, D., Nauenberg, U., Stenson, K., Wagner, S. R., Alexander, J., Cassel, D., Ecklund, K., Heltsley, B., Jones, C. D., Kuznetsov, V., Patterson, J. R., Ryd, A., Thom, J., Wittich, P., Beetz, C. P., Cirino, G., Podrasky, V., Sanzeni, C., Winn, D., Abdullin, S., Afaq, M. A., Albrow, M., Amundson, J., Apollinari, G., Atac, M., Badgett, W., Bakken, J. A., Baldin, B., Bauerdick, L. A. T., Baumbaugh, A., Baur, U., Bhat, P. C., Borcherding, F., Burkett, K., Butler, J. N., Cheung, H., Churin, I., Cihangir, S., Demarteau, M., Eartly, David P., Elias, J. E., Elvira, V. D., Fisk, I., Freeman, J., Gartung, P., Geurts, F. J. M., Glenzinski, D. A., Gottschalk, Erik Edward, Graham, G., Green, D., Guglielmo, G. M., Guo, Y., Gutsche, O., Hahn, A., Hanlon, J., Hansen, S., Harris, R. M., Hesselroth, T., Holm, S. L., Holzman, Burt, Iqbal, S., James, E., Johnson, M., Joshi, U., Klima, B., Kowalkowski, J., Kramer, T., Kwan, S., La Vallie, E., Larwill, M., Los, S., Lueking, L., Lukhanin, G., Lusin, S., Maeshima, K., Mcbride, P., Murray, S. J., O, V., Paterno, M., Patrick, J., Petravick, D., Pordes, Ruth, Prokofyev, O., Rasmislovich, V., Ratnikova, N., Ronzhin, A., Sekhri, V., Sexton-Kennedy, E., Shaw, T., Skow, D., Smith, R. P., Spalding, W. J., Spiegel, L., Stavrianakou, M., Stiehr, G., Suzuki, I., Tan, P., Tanenbaum, W., Tkaczyk, S., Veseli, S., Vidal, R., Wenzel, H., Whitmore, J., Womersley, W. J., Wu, W. M., Wu, Y., Yagil, A., Yarba, J., Yun, J. C., Avery, P., Barashko, V., Bartalini, P., Bourilkov, D., Cavanaugh, R., Drozdetskiy, A., Field, R. D., Fu, Y., Gray, L., Holmes, D., Kim, B. J., Klimenko, S., Konigsberg, J., Korytov, A., Kotov, K., Levchenko, P., Madorsky, A., Matchev, K., Mitselmakher, Guenakh, Pakhotin, Y., Prescott, C., Ramond, P., Rodriguez, J. L., Schmitt, M., Scurlock, B., Stoeck, H., Yelton, J., Boeglin, W., Gaultney, V., Kramer, L., Linn, S., Markowitz, P., Martinez, G., Raue, B., Reinhold, J., Askew, A., Bertoldi, M., Dharmaratna, Welathantri G. D., Gershtein, Y., Hagopian, S., Hagopian, V., Jenkins, M., Johnson, K. F., Prosper, H., Wahl, H., Baarmand, M., Baksay, L., Guragain, S., Hohlmann, M., Mermerkaya, H., Ralich, R., Vodopiyanov, I., Adams, M. R., Betts, R. R., Gerber, C. E., Shabalina, E., Smith, C., Ten, T., Akgun, U., Ayan, A. S., Cooper, A., Debbins, P., Duru, F., Fountain, M., George, N., Mccliment, E., Merlo, J. P., Mestvirishvili, A., Miller, M. J., Newsom, C. R., Norbeck, E., Onel, Y., Schmidt, I., Wang, S., Anderson, E. W., Atramentov, O., Hauptman, J. M., Lamsa, J., Barnett, B. A., Blumenfeld, Barry J., Chien, C. Y., Kim, D. W., Maksimovic, P., Spangler, S., Swartz, M., Baringer, Philip S., Bean, A., Coppage, D., Grachov, O. A., Kim, E. J., Murray, M., Bandurin, D., Bolton, T., Khanov, A., Maravin, Y., Onoprienko, D., Rizatdinova, F., Sidwell, R., Stanton, N., Toerne, E., Bard, R., Eno, S. C., Grassi, T., Hadley, N. J., Kellogg, R. G., Kunori, S., Ratnikov, F., Skuja, A., Arcidiacono, R., Ballintijn, M., Bauer, G., Harris, P., Kravchenko, I., Loizides, C., Nahn, S., Paus, C., Pavlon, S., Roland, C., Roland, G., Sumorok, K., Vaurynovich, S., Veres, G., Wyslouch, B., Bailleux, D., Corum, S., Cushman, P., Benedetti, A., Dolgopolov, A., Egeland, R., Franzoni, G., Gilbert, W. J., Grahl, J., Haupt, J., Kubota, Y., Mans, J., Pearson, N., Rusack, R., Singovsky, A., Cremaldi, L. M., Godang, R., Kroeger, R., Sanders, D. A., Summers, D., Bloom, K., Claes, D. R., Dominguez, A., Eads, M., Lundstedt, C., Malik, S., Snow, G. R., Sobol, A., Iashvili, I., Kharchilava, A., Alverson, G., Barberis, E., Boeriu, O., Eulisse, G., Musienko, Y., Muzaffar, S., Osborne, I., Reucroft, S., Swain, J., Taylor, L., Tuura, Lassi A., Wood, D., Gobbi, B., Kubantsev, M., Schellman, H., Spencer, E., Velasco, M., Baumbaugh, B., Cason, N. M., Hildreth, M., Karmgard, D. J., Marinelli, N., Ruchti, R., Warchol, J., Wayne, M., Bylsma, B., Durkin, L. S., Gilmore, J., Gu, J., Herman, D., Killewald, P., Knobbe, K., Ling, T. Y., Elmer, P., Marlow, D., Piroue, P., Stickland, D., Tully, C., Wildish, T., Wynhoff, S., Xie, Z., Apresyan, A., Arndt, K., Banicz, K., Barnes, V. E., Bolla, G., Bortoletto, D., Bujak, A., Garfinkel, A. F., Gonzalez Lopez, O., Gutay, L., Ippolito, N., Kozhevnikov, Y., Laasanen, A. T., Liu, C., Maroussov, V., Merkel, P., Miller, David Harry, Miyamoto, J., Neumeister, N., Rott, C., Roy, A., Sedov, A., Shipsey, I., Parashar, N., Eppley, G., Lee, S. J., Liu, J., Matveev, M., Nussbaum, T., Padley, B. Paul, Roberts, J., Tumanov, A., Yepes, P., Bodek, A., Budd, Howard Scott, Chung, Y. S., Barbaro, P., Demina, R., Eusebi, R., Ginther, G., Gotra, Y., Hocker, James Andrew, Husemann, U., Korjenevski, S., Sakumoto, W., Slattery, P., Tipton, P., Zielinski, M., Bartz, E., Doroshenko, J., Halkiadakis, E., Jacques, P. F., Kalelkar, M. S., Khits, D., Lath, A., Macpherson, A., Perera, L., Plano, R., Rose, K., Schnetzer, S., Somalwar, S., Stone, R., Thomson, G., Watts, T. L., Akchurin, N., Carrell, K. W., Gumus, Kazim Ziya, Jeong, C., Kim, H., Papadimitriou, V., Sill, A., Spezziga, M., Washington, E., Wigmans, R., Zhang, L., Bapty, T., Engh, D., Johns, W., Keskinpala, T., Luiggi Lopez, E., Neema, S., Nordstrom, S., Pathak, S., Sheldon, P., Vaandering, E. W., Webster, M., Arenton, M. W., Conetti, S., Cox, B., Hirosky, R., Imlay, R., Ledovskoy, A., Phillips, D., Powell, H., Ronquest, M., Smith, D., Baek, Y. W., Bellinger, James Nugent, Bradley, D., Carlsmith, D., Crotty, I., Dasu, S., Feyzi, F., Gorski, T., Grothe, M., Hogg, W., Jaworski, M., Klabbers, P., Lanaro, A., Loveless, R., Magrans Abril, M., Reeder, D., Smith, W. H., Wenman, D., Atoyan, G. S., Dhawan, S., Issakov, V., Neal, H., Poblaguev, A., Zeller, M. E., and Yuldashev, B. S.

856. SAMGrid integration of SRMs

Author: Kennedy, R. D., Baranovski, A., Garzoglio, G., Illingworth, R., Kreymer, A., Kumar, A., Loebel-Carpenter, L., Lueking, L., Lyon, A., Merritt, W., Terekhov, I., Trumbo, J., Veseli, S., White, S., Burgon-Lyon, M., St Denis, Richard Dante, Belforte, S., Kerzel, U., Bartsch, V., Leslie, M., Stonjek, S., Ratnikov, F., and Alan Fraser Sill
Subjects: Computing and Computers

857. The D0 data handling system

Author: White, V., Adams, D., Alcorn, B., Bakken, J., Bertram, I., Bos, K., Bonham, D., Colling, D., Demar, P., Diesburg, M., Duflot, L., Evans, D., Fagan, D., Fuess, S., Garzoglio, G., Graham, G., Gerald Guglielmo, Kumar, A., Kupco, A., Klima, B., Litmaath, M., Loebel-Carpenter, L., Lebrun, P., Lueking, L., Merritt, W., Moore, Carmenita, Moore, R., Petravick, D., Pordes, Ruth, Przybycien, M., Rockwell, T., Simmons, J., Schellman, H., Stanfield, N., Terekhov, I., Trumbo, J., Veseli, S., Leeuwen, W., Vranicar, M., Walker, R., Wellner, R., White, S., Wlodek, T., Wohlt, D., Womersley, J., Yip, Kin, Yu, J., and Zhang, D.

858. Housing metadata for the common physicist using a relational database

Author: St Denis, R., Burgon-Lyon, M., Doyle, A., Hanlon, S., Millar, P., Baranovski, A., Garzoglio, G., Herber, R., Illingworth, R., Kennedy, R., Kreymer, A., Kumar, A., Lueking, L., Merritt, W., Loebel-Carpenter, L., Lyon, A., Terekhov, I., Trumbo, J., Veseli, S., White, S., Vokac, P., Zimmler, M., Albrand, S., Fulachier, J., Barrass, T., Burke, S., Synge, O., Belforte, S., Kerzel, U., Leslie, M., Bartsch, V., Stonjek, S., Cioffi, C., Forti, Alessandra, Ratnikov, F., Alan Fraser Sill, Kunszt, P., Mccance, G., Nienartowicz, K., and Rocha, R.

859. A blockchain-based privacy-friendly renewable energy community

Author: Argjenta Veseli, Stephan Cejka, Mark Stefan, Franz Zeilinger, and Marie-Theres Holzleitner
Subjects: Blockchain, business.industry, Business, Environmental economics, Renewable energy

860. Evaluation of Privacy-ABC Technologies - a Study on the Computational Efficiency

Author: Jetzabel M. Serna and Fatbardh Veseli
Subjects: 0301 basic medicine, Computer science, business.industry, media_common.quotation_subject, Cryptography, Cloud service provider, Mathematical proof, Computer security, computer.software_genre, Credential, 03 medical and health sciences, Presentation, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Smart card, IBM, business, computer, media_common
Abstract: Privacy-enhancing attribute-based credential (Privacy-ABC) technologies use different cryptographic methods to enhance the privacy of the users. This results in important practical differences between these technologies, especially with regard to efficiency, which have not been studied in depth, but is necessary for assessing their suitability for different user devices and for highly dynamic scenarios. In this paper, we compare the computational efficiency of two prominent Privacy-ABC technologies, IBM’s Idemix and Microsoft’s U-Prove, covering all known Privacy-ABC features. The results show that overall presentation is in general is more efficient with Idemix, whereas U-Prove is more efficient for the User side (proving) operations during the presentation, and overall when there are more attributes in a credential. For both technologies we confirmed that inspectability, non-revocation proofs, and inequality predicates are costly operations. Interestingly, the study showed that equality predicates, the number of attributes in a credential, and attribute disclosure are done very efficiently. Finally, we identified a number of specific trust issues regarding Privacy-ABC technologies.
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861. JIM deployment for the CDF experiment

Author: Burgon-Lyon, M., Baranovski, A., Bartsch, V., Belforte, S., Garzoglio, G., Herber, Randolph, Illingworth, R., Kennedy, R., Kerzel, U., Kreymer, A., Leslie, M., Loebel-Carpenter, L., Lueking, L., Lyon, A., Merritt, W., Ratnikov, F., Alan Fraser Sill, St Denis, Richard Dante, Stonjek, S., Terekhov, I., Trumbo, J., Veseli, S., and White, S.
Subjects: Computing and Computers

862. Current methods and the ones in perspective for the determination of biogenic amines in food

Author: VESELİ, Albana, MEHMETİ, Eda, and VASJARİ, Majlinda
Subjects: Biyojenik aminler,gıda maddeleri,kromatografik yöntemler,elektrokimyasal yöntemler, Biogenic amines,food stuffs,chromatographic methods,electrochemical methods
Abstract: Biogenic amines are organic compounds, present in living organisms and they can be a responsibility for many essential processes. Naturally, they can be also in fruits and vegetable and all foods that contain free amino acids or proteins. In a high amount they can be produced by microorganism through the enzymatic reac- tion. Histamine, putrescine, cadaverine, tyramine, tryptamine, β-phenylethylamine, spermine and spermidine are considered to be the most important biogenic amines occurring in foods. Excessive consumption of these amines can inflict health concern and analysis of biogenic amines is important based on their toxicity and their usage as indicators of the degree of freshness or spoilage of food. Several methods exist for isolation, identif- ying and determination of biogenic amines in food. They are mainly based on chromatographic methods: thin layer chromatography TLC , gas chromatography GC , capillary electrophoresis CE and high-performance liquid chromatography HPLC . Due to the low volatility and lack of chromophores of most biogenic amines, UV- spectrometric detection is limited. A new challenge is electrochemical determination of those amines based on oxidative reaction. This review shows different methods which allow quantitative determination of biogenic amines in different food stuffs., B iyojenik aminler, canlı organizmalarda bulunan organik bileşiklerdir ve birçok temel işlemlerden sorumlu olabilirler. Meyve, sebze ve serbest amino asit veya protein içeren her gıdada doğal olarak bulunabilirler. Enzimatik tepkimeler yoluyla mikroorganizmalar tarafından yüksek miktarlarda üretilebilirler. Histamin, putresin, kadaverin, tiramin, triptamin, β-feniletilamin, spermin ve spermidin, gıdalarda en sık bulunan önemli biyojenik aminler olarak değerlendirilir. Bu aminlerin aşırı kullanımı, sağlık sorununa yol açabilir ve biyojenik aminlerin analizi, toksik etkilerinin ve tazelik veya bozulma derecelerinin bir göstergesi olarak oldukça önemlidir. Gıdalarda biyojenik aminlerin izolasyonu, tanımlanması ve tayini için çeşitli yöntemler mevcuttur. Bu yöntemler temel olarak kromatografik yöntemlerdir: ince tabaka kromatografisi TLC , gaz kromatografisi GC , kapiler elektroforez CE ve yüksek performans sıvı kromatografi HPLC . Birçok biyojenik aminlerin düşük uçuculuğu ve kromofor gruplarının olmaması dolayısıyla, UV-spektrometrik tayinleri sınırlıdır. Bu aminlerin tayini için yeni bir yöntem ise oksidatif tepkimelerinin elektrokimyasal izlenmesidir. Bu derlemede; farklı gıda numunelerinde biyojenik aminlerin kantitatif tayininde kullanılan çeşitli yöntemler gösterilmektedir

863. The diversity and functional capacity of microbes associated with coastal phototrophs

Author: Khashiff Miranda, Brooke L. Weigel, Emily C. Fogarty, Iva A. Veseli, Anne E. Giblin, A. Murat Eren, and Catherine A. Pfister
Abstract: Coastal marine phototrophs exhibit some of the highest rates of primary productivity in the world. They have been found to host a diverse set of microbes, many of which may impact the biology of their phototroph hosts through metabolisms that are unique to microbial taxa. Here we characterized the metabolic functions of phototroph-associated microbial communities using metagenomes collected from 2 species of kelp (Laminaria setchellii and Nereocystis luetkeana) and 3 marine angiosperms (Phyllospadix scouleri, P. serrulatus and Zostera marina), including the rhizomes of two surfgrass species (Phyllospadix spp.) and the seagrass Zostera marina, and the sediments surrounding P. scouleri and Z. marina. Using metagenomic sequencing, we describe 72 metagenome assembled genomes (MAGs) that potentially benefit from being associated with macrophytes and may contribute to macrophyte fitness through their metabolic gene content. All host-associated metagenomes contained genes for the use of dissolved organic matter from hosts and vitamin (B1, B2, B7, B12) biosynthesis. Additionally, we found a range of nitrogen metabolism genes that transform dissolved inorganic nitrogen into forms that may be more available to the host. The rhizosphere of surfgrass and seagrass contained genes for anaerobic microbial metabolisms, including nifH genes associated with nitrogen fixation, despite residing in a well-mixed and oxygenated environment. The range of oxygen environments engineered by macrophytes likely explains the diversity of both oxidizing and reducing microbial metabolisms, and contributes to the functional capabilities of microbes and their influence on carbon and nitrogen cycling in nearshore ecosystems.ImportanceKelps, seagrasses and surfgrasses are ecosystem engineers on rocky shorelines where they show remarkably high levels of primary production. Through analysis of their associated microbial communities, we found a variety of microbial metabolisms that may benefit the host, including nitrogen metabolisms and the production of B vitamins. In turn, these microbes have the genetic capability to assimilate the dissolved organic compounds released by their phototroph hosts. We describe a range of oxygen environments associated with surfgrass, including low-oxygen microhabitats in their rhizomes that host genes for nitrogen fixation. The tremendous productivity of coastal phototrophs is likely due in part to the activities of associated microbes and an increased understanding of these associations is needed.
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864. Report of the Tevatron Higgs working group

Author: Carena, Marcela, Conway, John S., Haber, Howard E., Hobbs, John D., Albrow, Michael G., Baer, Howard, Barberis, Emanuela, Barrientos Bendezu, A. A., Bhat, Pushpalatha, Belyaev, Alexander, Balazs, Csaba, Bokhari, Wasiq, Borzumati, Francesca, Chakraborty, Dhiman, Coarasa Perez, Jose Antonio, Culbertson, Ray, Demina, Regina, Diaz-Cruz, J. Lorenzo, Dicus, Duane, Dobrescu, Bogdan A., Dorigo, Tommaso, Dreiner, Herbert K., Ellis, R. Keith, Frisch, Henry J., Garcia, David, Gilmartin, Russell, Gonzalez-Garcia, Maria Concepion, Guasch, Jaume, Goussiou, Anna, Han, Tao, Harris, Brian W., He, Hong-Jian, Hedin, David, Heinemeyer, Sven, Heintz, Ulrich, Hollik, Wolfgang, Jesik, Richard, Kilminster, Ben, Kniehl, Bernd A., Kneur, Jean-Loic, Kuhlmann, Stephen, Kruse, Mark, Lami, Stefano, Landsberg, Greg L., Lietti, Sergio M., Litvintsev, Dmitri, Loomis, Charles, Lucotte, Arnaud, Matchev, Konstantin T., Mrenna, Stephen, Murat, Pasha, Novaes, Sergio F., Polonsky, Nir, Prosper, Harrison, Pukhov, Alexander, Ribon, Alberto, Roco, Maria, Rostovtsev, Andrey, Schmitt, Michael, Sirotenko, Vladimir, Snihur, Robert, Sola, Joan, Spira, Michael, Stelzer, Tim, Sullivan, Zack, Tait, Timothy M. P., Tata, Xerxes, Turcot, Andre S., Valls, Juan, Veseli, Sinisa, Vilar, Rocio, Watts, Gordon, Wagner, Carlos E. M., Weiglein, Georg, Willenbrock, Scott, Womersley, John, Yao, Weiming, Chien-Peng Yuan, Zeppenfeld, Dieter, and Zhang, Ren-Jie

865. Deployment of SAM for the CDF Experiment

Author: Stonjek, S., Baranovski, A., Kreymer, A., Lueking, L., Ratnikov, F., St Denis, Richard Dante, White, S., Merritt, W., Alan Fraser Sill, Burgon-Lyon, M., Leslie, M., Terekhov, I., Lyon, A., Bartsch, V., Belforte, S., Veseli, S., Loebel-Carpenter, L., Kerzel, U., Trumbo, J., Garzoglio, G., Herber, Randolph, Illingworth, R., and Kennedy, R.
Subjects: Computing and Computers

866. CMS physics Technical Design Report, Volume II: Physics Performance

Author: Bayatian, G L, Chatrchyan, S, Hmayakyan, G, Sirunyan, A M, Adam, W, Bergauer, T, Dragicevic, M, Ero, J, Friedl, M, Fruehwirth, R, Ghete, V, Glaser, P, Hrubec, J, Jeitler, M, Krammer, M, Magrans, I, Mikulec, I, Mitaroff, W, Noebauer, T, Pernicka, M, Porth, P, Rohringer, H, Strauss, J, Taurok, A, Waltenberger, W, Walzel, G, Widl, E, Wulz, C-E, Fedorov, A, Korzhik, M, Missevitch, O, Zuyeuski, R, Chekhovsky, V, Dvornikov, O, Emeliantchik, I, Litomin, A, Mossolov, V, Shumeiko, N, Solin, A, Stefanovitch, R, Suarez Gonzalez, J, Tikhonov, A, Petrov, V, D'Hondt, J, De Weirdt, S, Goorens, R, Heyninck, J, Lowette, S, Tavernier, S, Van Doninck, Walter, Van Lancker, L, Bouhali, O, Clerbaux, B, De Lentdecker, G, Dewulf, J P, Mahmoud, T, Marage, P E, Neukermans, L, Sundararajan, V, Vander Velde, C, Vanlaer, P, Wickens, J, Assouak, S, Bonnet, J L, Bruno, G, Caudron, J, De Callatay, B, De Favereau De Jeneret, J, De Visscher, Simon, Delaere, C, Demin, P, Favart, D, Feltrin, E, Forton, E, Gregoire, G, Kalinin, S, Kcira, D, Keutgen, T, Leibenguth, G, Lemaitre, V, Liu, Y, Michotte, D, Militaru, O, Ninane, A, Ovyn, S, Pierzchala, T, Piotrzkowski, K, Roberfroid, V, Rouby, X, Teyssier, D, Van der Aa, O, Vander Donckt, M, Daubie, E, Herquet, P, Mollet, A, Romeyer, A, Beaumont, W, Cardaci, M, De Langhe, E, De Wolf, E A, Rurua, L, Souza, M H G, Oguri, V, Santoro, A, Sznajder, A, Vaz, M, Gregores, E M, Novaes, S F, Anguelov, T, Antchev, G, Atanasov, I, Damgov, J, Darmenov, N, Dimitrov, L, Genchev, V, Iaydjiev, P, Panev, B, Piperov, Stefan, Stoykova, S, Sultanov, G, Vankov, I, Dimitrov, A, Kozhuharov, V, Litov, L, Makariev, M, Marinov, A, Marinova, E, Markov, S, Mateev, M, Pavlov, B, Petkov, P, Sabev, C, Stoynev, S, Toteva, Z, Verguilov, V, Chen, G M, Chen, H S, He, K L, Jiang, C H, Li, W G, Liu, H M, Meng, X, Shen, X Y, Sun, H S, Yang, M, Zhao, W R, Zhuang, H L, Ban, Y, Cai, J, Liu, S, Qian, S J, Yang, Z C, Ye, Y L, Ying, J, Wu, J, Zhang, Z P, Godinovic, N, Puljak, I, Soric, I, Antunovic, Z, Dzelalija, M, Marasovic, K, Brigljevic, V, Ferencek, D, Kadija, K, Morovic, S, Planinic, M, Nicolaou, C, Papadakis, A, Razis, P A, Tsiakkouri, D, Hektor, A, Kadastik, M, Kannike, K, Lippmaa, E, Muntel, M, Raidal, M, Aarnio, P A, Czellar, S, Haeggstroem, E, Heikkinen, A, Harkonen, J, Karimaki, V, Kinnunen, R, Lampen, T, Lassila-Perini, K, Lehti, S, Linden, T, Luukka, P R, Michal, S, Maenpaa, T, Nysten, J, Stettler, M, Tuominen, E, Tuominiemi, J, Wendland, L, Tuuva, T, Guillaud, J P, Nedelec, P, Sillou, D, Anfreville, M, Beauceron, S, Bougamont, E, Bredy, P, Chipaux, R, Dejardin, M, Denegri, D, Descamps, J, Fabbro, B, Faure, J L, Ganjour, S, Gentit, F X, Givernaud, A, Gras, P, Hamel de Monchenault, G, Jarry, P, Kircher, F, Lemaire, M C, Levesy, B, Locci, E, Lottin, J P, Mandjavidze, I, Mur, M, Pasquetto, E, Payn, A, Rander, J, Reymond, J M, Rondeaux, F, Rosowsky, A, Sun, Z H, Verrecchia, P, Baffioni, S, Beaudette, F, Bercher, M, Berthon, U, Bimbot, S, Bourotte, J, Busson, P, Cerutti, M, Chamont, D, Charlot, C, Collard, C, Decotigny, D, Delmeire, E, Dobrzynski, L, Gaillac, A M, Geerebaert, Y, Gilly, J, Haguenauer, M, Karar, A, Mathieu, A, Milleret, G, Mine, P, Paganini, P, Romanteau, T, Semeniouk, I, Sirois, Y, Berst, J D, Brom, J M, Didierjean, F, Drouhin, F, Fontaine, J C, Goerlach, U, Graehling, P, Gross, L, Houchu, L, Juillot, P, Lounis, A, Maazouzi, C, Mangeol, D, Olivetto, C, Todorov, T, Van Hove, P, Vintache, D, Ageron, M, Agram, J L, Baulieu, G, Bedjidian, M, Blaha, J, Bonnevaux, A, Boudoul, G, Chabanat, E, Combaret, C, Contardo, D, Della Negra, R, Depasse, P, Dupasquier, T, El Mamouni, H, Estre, N, Fay, J, Gascon, S, Giraud, N, Girerd, C, Haroutunian, R, Ianigro, J C, Ille, B, Lethuillier, M, Lumb, N, Mathez, H, Maurelli, G, Mirabito, L, Perries, S, Ravat, O, Kvatadze, R, Roinishvili, V, Adolphi, R, Brauer, R, Braunschweig, W, Esser, H, Feld, L, Heister, A, Karpinski, W, Klein, K, Kukulies, C, Olzem, J, Ostapchuk, A, Pandoulas, D, Pierschel, G, Raupach, F, Schael, S, Schwering, G, Thomas, M, Weber, M, Wittmer, B, Wlochal, M, Adolf, A, Biallass, Philipp A, Bontenackels, M, Erdmann, M, Fesefeldt, H, Hebbeker, T, Hermann, S, Hilgers, G, Hoepfner, K, Hof, C, Kappler, S, Kirsch, M, Lanske, D, Philipps, B, Reithler, H, Rommerskirchen, T, Sowa, M, Szczesny, H, Tonutti, M, Tsigenov, O, Beissel, F, Davids, M, Duda, M, Flugge, G, Franke, T, Giffels, M, Hermanns, T, Heydhausen, D, Kasselmann, S, Kaussen, G, Kress, T, Linn, A, Nowack, A, Poettgens, M, Pooth, O, Stahl, A, Tornier, D, Flossdorf, A, Hegner, B, Mnich, J, Rosemann, C, Flucke, G, Holm, U, Klanner, R, Pein, U, Schirm, N, Schleper, P, Steinbruck, G, Stoye, M, Van Staa, R, Wick, K, Blum, P, Buege, V, De Boer, W, Dirkes, G, Fahrer, M, Feindt, M, Felzmann, U, Fernandez Menendez, J, Frey, M, Furgeri, A, Hartmann, F, Heier, S, Jung, C, Ledermann, B, Muller, Th, Niegel, M, Oehler, A, Ortega Gomez, T, Piasecki, C, Quast, G, Rabbertz, K, Saout, C, Scheurer, A, Schieferdecker, D, Schmidt, A, Simonis, H J, Theel, A, Vest, A, Weiler, T, Weiser, C, Weng, J, Zhukov, V, Karapostoli, G, Katsas, P, Kreuzer, P, Panagiotou, A, Papadimitropoulos, C, Anagnostou, G, Barone, M, Geralis, T, Kalfas, C, Koimas, A, Kyriakis, A, Kyriazopoulou, S, Loukas, D, Markou, A, Markou, C, Mavrommatis, C, Theofilatos, K, Vermisoglou, G, Zachariadou, A, Aslanoglou, X, Evangelou, I, Kokkas, P, Manthos, N, Papadopoulos, I, Sidiropoulos, G, Triantis, F A, Bencze, G, Boldizsar, L, Hajdu, C, Horvath, D, Laszlo, A, Odor, G, Sikler, F, Toth, N, Vesztergombi, G, Zalan, P, Molnar, J, Beni, N, Kapusi, A, Marian, G, Raics, P, Szabo, Z, Szillasi, Z, Zilizi, G, Bawa, H S, Beri, S B, Bhandari, V, Bhatnagar, V, Kaur, M, Kaur, R, Kohli, J M, Kumar, A, Singh, J B, Bhardwaj, A, Bhattacharya, S, Chatterji, S, Chauhan, S, Choudhary, B C, Gupta, P, Jha, M, Ranjan, K, Shivpuri, R K, Srivastava, A K, Borkar, S, Dixit, M, Ghodgaonkar, M, Kataria, S K, Lalwani, S K, Mishra, V, Mohanty, A K, Topkar, A, Aziz, T, Banerjee, S, Bose, S, Cheere, N, Chendvankar, S, Deshpande, P V, Guchait, M, Gurtu, A, Maity, M, Majumder, G, Mazumdar, K, Nayak, A, Patil, M R, Sharma, S, Sudhakar, K, Tonwar, S C, Acharya, Bannanje Sripath, Bheesette, S, Dugad, S, Kalmani, S D, Lakkireddi, V R, Mondal, N K, Panyam, N, Verma, P, Arabgol, M, Arfaei, H, Hashemi, M, Mohammadi, M, Mohammadi Najafabadi, M, Moshaii, A, Paktinat Mehdiabadi, S, Grunewald, M, Abbrescia, M, Barbone, L, Colaleo, A, Creanza, D, De Filippis, N, De Palma, M, Donvito, G, Fiore, L, Giordano, D, Iaselli, G, Loddo, F, Maggi, G, Maggi, M, Manna, N, Marangelli, B, Mennea, M S, My, S, Natali, S, Nuzzo, S, Pugliese, G, Radicci, V, Ranieri, A, Romano, F, Selvaggi, G, Silvestris, L, Tempesta, P, Trentadue, R, Zito, G, Abbiendi, G, Bacchi, W, Benvenuti, A, Bonacorsi, D, Braibant-Giacomelli, S, Capiluppi, P, Cavallo, F R, Ciocca, C, Codispoti, G, D'Antone, I, Dallavalle, G M, Fabbri, F, Fanfani, A, Giacomelli, P, Grandi, C, Guerzoni, M, Guiducci, L, Marcellini, S, Masetti, G, Montanari, A, Navarria, F, Odorici, F, Perrotta, A, Rossi, A, Rovelli, T, Siroli, G, Travaglini, R, Albergo, S, Chiorboli, M, Costa, S, Galanti, M, Gatto Rotondo, G, Noto, F, Potenza, R, Russo, G, Tricomi, A, Tuve, C, Bocci, A, Ciraolo, G, Ciulli, V, Civinini, C, D'Alessandro, R, Focardi, E, Genta, C, Lenzi, P, Macchiolo, A, Magini, N, Manolescu, F, Marchettini, C, Masetti, L, Mersi, S, Meschini, M, Paoletti, S, Parrini, G, Ranieri, R, Sani, M, Fabbricatore, P, Farinon, S, Greco, Mario, Cattaneo, G, De Min, A, Dominoni, M, Farina, F M, Ferri, F, Ghezzi, A, Govoni, P, Leporini, R, Magni, S, Malberti, M, Malvezzi, S, Marelli, S, Menasce, D, Moroni, L, Negri, P, Paganoni, M, Pedrini, D, Pullia, A, Ragazzi, S, Redaelli, Nicola Giuseppe, Rovelli, C, Rovere, M, Sala, L, Sala, S, Salerno, R, Tabarelli de Fatis, T, Vigano, S, Comunale, G, Fabozzi, F, Lomidze, D, Mele, S, Paolucci, P, Piccolo, D, Polese, G, Sciacca, C, Azzi, P, Bacchetta, N, Bellato, M, Benettoni, M, 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Gennai, S, Giammanco, A, Giassi, A, Kartashov, D, Ligabue, F, Linari, S, Lomtadze, T, Lungu, G A, Mangano, B, Martinelli, G, Massa, M, Messineo, A, Moggi, A, Palla, F, Palmonari, F, Petrucciani, G, Raffaelli, F, Rizzi, A, Sanguinetti, G, Segneri, G, Sentenac, D, Serban, A T, Sguazzoni, G, Slav, A, Spagnolo, P, Tenchini, R, Tonelli, G, Venturi, A, Verdini, P G, Vos, M, Baccaro, S, Barone, L, Bartoloni, A, Cavallari, F, Costantini, S, Dafinei, I, Del Re, D, Diemoz, M, Gargiulo, C, Longo, E, Meridiani, P, Organtini, G, Rahatlou, S, Accomando, E, Arneodo, M, Ballestrero, A, Bellan, R, Biino, C, Bolognesi, S, Cartiglia, N, Cerminara, G, Cordero, M, Costa, M, Dellacasa, G, Demaria, N, Maina, E, Mariotti, C, Maselli, S, Mereu, P, Migliore, E, Monaco, V, Nervo, M, Obertino, M M, Pastrone, N, Petrillo, G, Romero, A, Ruspa, M, Sacchi, R, Staiano, A, Trapani, P P, Belforte, S, Cossutti, F, Della Ricca, G, Penzo, A, Cho, K, Ham, S W, Han, D, Kim, D H, Kim, G N, Kim, J C, Kim, W Y, Lee, M W, Oh, S K, Park, W H, Ro, S R, Son, D C, Suh, J S, Kim, J Y, Jung, S Y, Rhee, J T, Hong, B S, Hong, S J, Lee, K S, Park, I, Park, S K, Sim, K S, Won, E, Kim, S B, Carrillo Moreno, S, Castilla Valdez, H, Sanchez Hernandez, A, Salazar Ibarguen, H A, Morelos Pineda, Antonio, Gray, R N C, Krofcheck, D, Bernardino Rodrigues, N, Butler, Philip H, Williams, J C, Aftab, Z, Ahmad, M, Ahmad, U, Ahmed, I, Alam Jan, J, Asghar, M I, Asghar, S, Hafeez, M, Hoorani, H R, Ibrahim, M, Iftikhar, M, Khan, M S, Qaiser, N, Rehman, I, Solaija, T, Toor, S, Blocki, J, Cyz, A, Gladysz-Dziadus, E, Mikocki, S, Turnau, J, Wlodarczyk, Z, Zychowski, P, Bunkowski, K, Czyrkowski, H, Dabrowski, R, Dominik, W, Doroba, K, Kalinowski, A, Konecki, M, Krolikowski, J, Kudla, Ignacy M, Pietrusinski, M, Pozniak, K, Zabolotny, W, Zych, P, Bluj, M, Gokieli, R, Goscilo, L, Gorski, M, Nawrocki, K, Traczyk, P, Wrochna, G, Zalewski, P, Alemany-Fernandez, R, Almeida, C, Almeida, N, Araujo Trindade, A, Bordalo, P, Da Silva Rodrigues, P, 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Otwinowski, S, Rakness, G, Schlein, P, Shi, Y, Tucker, J, Valuev, V, Wallny, R, Wang, H G, Yang, X, Zheng, Y, Clare, R, Fortin, D, Futyan, D, Gary, John William, Giunta, Marina, Hanson, G, Jeng, G Y, Kao, S C, Liu, H, Pasztor, G, Satpathy, A, Shen, B C, Stringer, R, Sytnik, V, Wilken, R, Zer-Zion, D, Branson, J G, Dusinberre Sudano, Elizabeth Jane, Letts, J, Martin, T, Mojaver, M, Paar, H P, Pi, H, Pieri, M, Rana, A, Sharma, V, White, A, Wuerthwein, Frank K, Affolder, A, Campagnari, C, Hill, C, Incandela, J, Kyre, S, Lamb, J, Richman, J, Stuart, D, White, D, Albert, J, Bornheim, A, Bunn, J, Chen, J, Denis, G, Galvez, P, Gataullin, M, Legrand, I, Litvine, Vladimir A, Ma, Y, Nae, D, Newman, H B, Ravot, S, Shevchenko, S, Singh, S, Steenberg, C, Su, X, Timciuc, V, van Lingen, F, Veverka, J, Voicu, B R, Weinstein, A, Wilkinson, R, Yang, Y, Zhang, L Y, Zhu, K, Zhu, R Y, Ferguson, T, Paulini, M, Russ, J, Terentyev, N, Vogel, H, Vorobiev, I, Cumalat, J P, Ford, William T, Johnson, D, Nauenberg, U, Stenson, K, Wagner, S R, Alexander, J, Cassel, D, Ecklund, K, Heltsley, B, Jones, C D, Kuznetsov, V, Patterson, J R, Ryd, A, Thom, J, Wittich, P, Beetz, C P, Cirino, G, Podrasky, V, Sanzeni, C, Winn, D, Abdullin, S, Afaq, M A, Albrow, M, Amundson, J, Apollinari, G, Atac, M, Badgett, W, Bakken, J A, Baldin, B, Bauerdick, L A T, Baumbaugh, A, Baur, U, Bhat, P C, Borcherding, F, Burkett, K, Butler, J N, Cheung, H, Churin, I, Cihangir, S, Demarteau, M, Eartly, David P, Elias, J E, Elvira, V D, Fisk, I, Freeman, J, Gartung, P, Geurts, F J M, Glenzinski, D A, Gottschalk, Erik Edward, Graham, G, Green, D, Guglielmo, G M, Guo, Y, Gutsche, O, Hahn, A, Hanlon, J, Hansen, S, Harris, R M, Hesselroth, T, Holm, S L, Holzman, Burt, Iqbal, S, James, E, Johnson, M, Joshi, U, Klima, B, Kowalkowski, J, Kramer, T, Kwan, S, La Vallie, E, Larwill, M, Los, S, Lueking, L, Lukhanin, G, Lusin, S, Maeshima, K, McBride, P, Murray, S J, O'Dell, V, Paterno, M, Patrick, J, Petravick, D, Pordes, Ruth, Prokofyev, O, Rasmislovich, V, Ratnikova, N, Ronzhin, A, Sekhri, V, Sexton-Kennedy, E, Shaw, T, Skow, D, Smith, R P, Spalding, W J, Spiegel, L, Stavrianakou, M, Stiehr, G, Suzuki, I, Tan, P, Tanenbaum, W, Tkaczyk, S, Veseli, S, Vidal, R, Wenzel, H, Whitmore, J, Womersley, W J, Wu, W M, Wu, Y, Yagil, A, Yarba, J, Yun, J C, Acosta, D, Avery, P, Barashko, V, Bartalini, P, Bourilkov, D, Cavanaugh, R, Drozdetskiy, A, Field, R D, Fu, Y, Gray, L, Holmes, D, Kim, B J, Klimenko, S, Konigsberg, J, Korytov, A, Kotov, K, Levchenko, P, Madorsky, A, Matchev, K, Mitselmakher, Guenakh, Pakhotin, Y, Prescott, C, Ramond, P, Rodriguez, J L, Schmitt, M, Scurlock, B, Stoeck, H, Yelton, J, Boeglin, W, Gaultney, V, Kramer, L, Linn, S, Markowitz, P, Martinez, G, Raue, B, Reinhold, J, Askew, A, Bertoldi, M, Dharmaratna, Welathantri G D, Gershtein, Y, Hagopian, S, Hagopian, V, Jenkins, M, Johnson, K F, Prosper, H, Wahl, H, Baarmand, M, Baksay, L, Guragain, S, Hohlmann, M, Mermerkaya, H, Ralich, R, Vodopiyanov, I, Adams, M R, Betts, R R, Gerber, C E, Shabalina, E, Smith, C, Ten, T, Akgun, U, Ayan, A S, Cooper, A, Debbins, P, Duru, F, Fountain, M, George, N, McCliment, E, Merlo, J P, Mestvirishvili, A, Miller, M J, Newsom, C R, Norbeck, E, Onel, Y, Schmidt, I, Wang, S, Anderson, E W, Atramentov, O, Hauptman, J M, Lamsa, J, Barnett, B A, Blumenfeld, Barry J, Chien, C Y, Kim, D W, Maksimovic, P, Spangler, S, Swartz, M, Baringer, Philip S, Bean, A, Coppage, D, Grachov, O A, Kim, E J, Murray, M, Bandurin, D, Bolton, T, Khanov, A, Maravin, Y, Onoprienko, D, Rizatdinova, F, Sidwell, R, Stanton, N, Von Toerne, E, Baden, D, Bard, R, Eno, S C, Grassi, T, Hadley, N J, Kellogg, R G, Kunori, S, Ratnikov, F, Skuja, A, Arcidiacono, R, Ballintijn, M, Bauer, G, Harris, P, Kravchenko, I, Loizides, C, Nahn, S, Paus, C, Pavlon, S, Roland, C, Roland, G, Sumorok, K, Vaurynovich, S, Veres, G, Wyslouch, B, Bailleux, D, Corum, S, Cushman, P, De Benedetti, A, Dolgopolov, A, Egeland, R, Franzoni, G, Gilbert, W J, Grahl, J, Haupt, J, Kubota, Y, Mans, J, Pearson, N, Rusack, R, Singovsky, A, Cremaldi, L M, Godang, R, Kroeger, R, Sanders, D A, Summers, D, Bloom, Kenneth A, Claes, D R, Dominguez, A, Eads, M, Lundstedt, C, Malik, S, Snow, G R, Sobol, A, Iashvili, I, Kharchilava, A, Alverson, G, Barberis, E, Boeriu, O, Eulisse, G, Musienko, Y, Muzaffar, S, Osborne, I, Reucroft, S, Swain, J, Taylor, L, Tuura, Lassi A, Wood, D, Gobbi, B, Kubantsev, M, Schellman, H, Spencer, E, Velasco, M, Baumbaugh, B, Cason, N M, Hildreth, M, Karmgard, D J, Marinelli, N, Ruchti, R, Warchol, J, Wayne, M, Bylsma, B, Durkin, L S, Gilmore, J, Gu, J, Herman, D, Killewald, P, Knobbe, K, Ling, T Y, Elmer, P, Marlow, D, Piroue, P, Stickland, D, Tully, C, Wildish, T, Wynhoff, S, Xie, Z, Apresyan, A, Arndt, K, Banicz, K, Barnes, V E, Bolla, G, Bortoletto, D, Bujak, A, Garfinkel, A F, Gonzalez Lopez, O, Gutay, L, Ippolito, N, Kozhevnikov, Y, Laasanen, A T, Liu, C, Maroussov, V, Merkel, P, Miller, David Harry, Miyamoto, J, Neumeister, N, Rott, C, Roy, A, Sedov, A, Shipsey, I, Parashar, N, Eppley, G, Lee, S J, Liu, J, Matveev, M, Nussbaum, T, Padley, B Paul, Roberts, J, Tumanov, A, Yepes, P, Bodek, A, Budd, Howard Scott, Chung, Y S, De Barbaro, P, Demina, R, Eusebi, R, Ginther, G, Gotra, Y, Hocker, James Andrew, Husemann, U, Korjenevski, S, Sakumoto, W, Slattery, P, Tipton, P, Zielinski, M, Bartz, E, Doroshenko, J, Halkiadakis, E, Jacques, P F, Kalelkar, M S, Khits, D, Lath, A, Macpherson, A, Perera, L, Plano, R, Rose, K, Schnetzer, S, Somalwar, S, Stone, R, Thomson, G, Watts, T L, Akchurin, N, Carrell, K W, Gumus, Kazim Ziya, Jeong, C, Kim, H, Papadimitriou, V, Sill, A, Spezziga, M, Washington, E, Wigmans, R, Zhang, L, Bapty, T, Engh, D, Johns, W, Keskinpala, T, Luiggi Lopez, E, Neema, S, Nordstrom, S, Pathak, S, Sheldon, P, Vaandering, E W, Webster, M, Arenton, M W, Conetti, S, Cox, B, Hirosky, R, Imlay, R, Ledovskoy, A, Phillips, D II, Powell, H, Ronquest, M, Smith, D, Baek, Y W, Bellinger, James Nugent, Bradley, D, Carlsmith, D, Crotty, I, Dasu, S, Feyzi, F, Gorski, T, Grothe, M, Hogg, W, Jaworski, M, Klabbers, P, Lanaro, A, Loveless, R, Magrans de Abril, M, Reeder, D, Smith, W H, Wenman, D, Atoyan, G S, Dhawan, S, Issakov, V, Neal, H, Poblaguev, A, Zeller, M E, and Yuldashev, B S

867. Kadri Veseli: “Kosovo needs an army – we are worried about increasing Russian influence, the rise of extremism and Serbian provocations”

Author: Veseli, Kadri, EUROPP, LSE, Veseli, Kadri, and EUROPP, LSE
Abstract: In an interview with EUROPP’s editors, Kadri Veseli, the Speaker of the Kosovo Parliament and Chairman of the country’s largest political party, PDK, states that the people of Kosovo are sick and tired of politicians, with global pop stars and sportswomen being better ambassadors for the country than most members of parliament. He reflects on the difficulties posed by a disadvantageous visa regime, reacts to Aleksandar Vucic’s election as President of Serbia, and outlines why he believes it is important to set up a Kosovo army.

868. Semiempirical studies of core electron binding energies Part II. SCC-MO Calculations for uracil and its derivatives

Author: Maksić, Z.B., primary, Rupnik, K., additional, and Veseli, A., additional
Published: 1983
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869. Metabolic Resistance and Not Voltage-Gated Sodium Channel Gene Mutation Is Associated with Pyrethroid Resistance of Aedes albopictus (Skuse, 1894) from Cambodia.

Author: Marcombe, Sébastien, Doeurk, Bros, Thammavong, Phoutmany, Veseli, Tuba, Heafield, Christian, Mills, Molly-Ann, Kako, Sedra, Prado, Marcelly Ferreira, Thomson, Shakira, Millett, Saffron, Hill, Timothy, Kentsley, Imogen, Davies, Shereena, Pathiraja, Geethika, Daniels, Ben, Browne, Lucianna, Nyamukanga, Miranda, Harvey, Jess, Rubinstein, Lyranne, and Townsend, Chloe
Subjects: *PYRETHROIDS, *AEDES albopictus, *SODIUM channels, *GENETIC mutation, *DELTAMETHRIN, *MOSQUITO-borne diseases
Abstract: Simple Summary: The tiger mosquito, Aedes albopictus, spreads the virus causing dengue fever, notably in Southeast Asian countries. To stop the spread of this disease, the Aedes mosquitoes are killed with chemicals known as pyrethroids. However, despite pyrethroids being highly effective insecticides, tiger mosquitoes are becoming resistant and surviving exposure to these chemicals. We have measured that tiger mosquitoes from two regions in Cambodia (the capital, Phnom Penh, and rural Pailin province) are highly resistant to pyrethroids. To determine what causes resistance, we have implicated unusually high activity of enzymes, known as P450 monooxygenases, which break down pyrethroids and thus render them harmless in the resistant mosquitoes. We have ruled out another common mechanism of pyrethroid resistance, which is changes in the mosquitoes' DNA sequence, which prevents pyrethroids from binding to a protein known as the voltage-gated sodium channel, thereby disrupting signals being sent throughout the nervous system. Overall, our findings describe an important survey monitoring the prevalence of insecticide resistance in disease-spreading mosquitoes in Cambodia, and with the increased understanding of what causes resistance, we are in a strong position to advise that mosquito control methods alternative to pyrethroids should be implemented as soon as possible to ensure continuing management of dengue fever. (1) Background: In Cambodia, Aedes albopictus is an important vector of the dengue virus. Vector control using insecticides is a major strategy implemented in managing mosquito-borne diseases. Resistance, however, threatens to undermine the use of insecticides. In this study, we present the levels of insecticide resistance of Ae. albopictus in Cambodia and the mechanisms involved. (2) Methods: Two Ae. albopictus populations were collected from the capital, Phnom Penh city, and from rural Pailin province. Adults were tested with diagnostic doses of malathion (0.8%), deltamethrin (0.03%), permethrin (0.25%), and DDT (4%) using WHO tube assays. Synergist assays using piperonyl butoxide (PBO) were implemented before the pyrethroid assays to detect the potential involvement of metabolic resistance mechanisms. Adult female mosquitoes collected from Phnom Penh and Pailin were tested for voltage-gated sodium channel (VGSC) kdr (knockdown resistance) mutations commonly found in Aedes sp.-resistant populations throughout Asia (S989P, V1016G, and F1534C), as well as for other mutations (V410L, L982W, A1007G, I1011M, T1520I, and D1763Y). (3) Results: The two populations showed resistance against all the insecticides tested (<90% mortality). The use of PBO (an inhibitor of P450s) strongly restored the efficacy of deltamethrin and permethrin against the two resistant populations. Sequences of regions of the vgsc gene showed a lack of kdr mutations known to be associated with pyrethroid resistance. However, four novel non-synonymous mutations (L412P/S, C983S, Q1554STOP, and R1718L) and twenty-nine synonymous mutations were detected. It remains to be determined whether these mutations contribute to pyrethroid resistance. (4) Conclusions: Pyrethroid resistance is occurring in two Ae. albopictus populations originating from urban and rural areas of Cambodia. The resistance is likely due to metabolic resistance specifically involving P450s monooxygenases. The levels of resistance against different insecticide classes are a cause for concern in Cambodia. Alternative tools and insecticides for controlling dengue vectors should be used to minimize disease prevalence in the country. [ABSTRACT FROM AUTHOR]
Published: 2024
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870. Existenz der Wellenoperatoren f�r eine allgemeine Klasse von Operatoren

Author: Veseli?, Kre?imir, primary and Weidmann, Joachim, additional
Published: 1973
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871. Genetic control of the phenobarbital-induced shortening of plasma antipyrine half-lives in man

Author: Veseli, Elliot S., primary and Page, John G., additional
Published: 1969
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872. Distributed data access and resource management in the D0 SAM system

Author: Terekhov, I., primary, Pordes, R., additional, White, V., additional, Lueking, L., additional, Carpenter, L., additional, Schellman, H., additional, Trumbo, J., additional, Veseli, S., additional, Vranicar, M., additional, and White, S., additional
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873. Abstract 15312: Predictors for Defibrillator Therapy in Modern Urban Cohort of Patients With Heart Failure.

Author: Abrahim, Christian, Kane, Jesse, Kurtz, Jack, Nath, Sridesh, Veseli, Granit, and Budzikowski, Adam
Published: 2018

874. The PFKFB3 Inhibitor AZ67 Inhibits Angiogenesis Independently of Glycolysis Inhibition

Author: Besa Emini Veseli, Pieter Van Wielendaele, Mirela Delibegovic, Wim Martinet, and Guido R.Y. De Meyer
Subjects: Phosphofructokinase-2, Angiogenesis, QH301-705.5, Neovascularization, Physiologic, Article, Catalysis, Cell Line, Inorganic Chemistry, Mice, 03 medical and health sciences, Glycolysis Inhibition, angiogenesis, 0302 clinical medicine, PFKFB3, In vivo, AZ PFKFB3 67, medicine, Animals, Humans, Glycolysis, Enzyme Inhibitors, Physical and Theoretical Chemistry, Biology (General), Molecular Biology, QD1-999, Biology, Spectroscopy, Cell Proliferation, 030304 developmental biology, 0303 health sciences, Chemistry, Pharmacology. Therapy, Organic Chemistry, General Medicine, Metabolism, In vitro, endothelial cells, Computer Science Applications, Cell biology, Mice, Inbred C57BL, Endothelial stem cell, Mechanism of action, 030220 oncology & carcinogenesis, Human medicine, medicine.symptom, Protein Binding
Abstract: Angiogenesis is the process of new blood vessel formation. In this complex orchestrated growth, many factors are included. Lately, focus has shifted to endothelial cell metabolism, particularly to the PFKFB3 protein, a key regulatory enzyme of the glycolytic pathway. A variety of inhibitors of this important target have been studied, and a plethora of biological effects related to the process of angiogenesis have been reported. However, recent studies have disputed their mechanism of action, questioning whether all the effects are indeed due to PFKFB3 inhibition. Remarkably, the most well-studied inhibitor, 3PO, does not bind to PFKFB3, raising questions about this target. In our study, we aimed to elucidate the effects of PFKFB3 inhibition in angiogenesis by using the small molecule AZ67. We used isothermal titration calorimetry and confirmed binding to PFKFB3. In vitro, AZ67 did not decrease lactate production in endothelial cells (ECs), nor ATP levels, but exhibited good inhibitory efficacy in the tube-formation assay. Surprisingly, this was independent of EC migratory and proliferative abilities, as this was not diminished upon treatment. Strikingly however, even the lowest dose of AZ67 demonstrated significant inhibition of angiogenesis in vivo. To our knowledge, this is the first study to demonstrate that the process of angiogenesis can be disrupted by targeting PFKFB3 independently of glycolysis inhibition.
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875. Microbial associates of an endemic Mediterranean seagrass enhance the access of the host and the surrounding seawater to inorganic nitrogen under ocean acidification.

Author: Pfister, Catherine A., Cardini, Ulisse, Mirasole, Alice, Montilla, Luis M., Veseli, Iva, Gattuso, Jean-Pierre, and Teixido, Nuria
Subjects: *OCEAN acidification, *SEAGRASSES, *SEAWATER, *TERRITORIAL waters, *ISOTOPE separation, *CARBON fixation
Abstract: Seagrasses are important primary producers in oceans worldwide. They live in shallow coastal waters that are experiencing carbon dioxide enrichment and ocean acidification. Posidonia oceanica, an endemic seagrass species that dominates the Mediterranean Sea, achieves high abundances in seawater with relatively low concentrations of dissolved inorganic nitrogen. Here we tested whether microbial metabolisms associated with P. oceanica and surrounding seawater enhance seagrass access to nitrogen. Using stable isotope enrichments of intact seagrass with amino acids, we showed that ammonification by free-living and seagrass-associated microbes produce ammonium that is likely used by seagrass and surrounding particulate organic matter. Metagenomic analysis of the epiphytic biofilm on the blades and rhizomes support the ubiquity of microbial ammonification genes in this system. Further, we leveraged the presence of natural carbon dioxide vents and show that the presence of P. oceanica enhanced the uptake of nitrogen by water column particulate organic matter, increasing carbon fixation by a factor of 8.6–17.4 with the greatest effect at CO2 vent sites. However, microbial ammonification was reduced at lower pH, suggesting that future ocean climate change will compromise this microbial process. Thus, the seagrass holobiont enhances water column productivity, even in the context of ocean acidification. [ABSTRACT FROM AUTHOR]
Published: 2023
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876. Advanced Computational Technologies for Experiment Control, Data Acquisition, and Data Analysis at the Advanced Photon Source.

Author: Hammonds, John, Henke, Steven, Jemian, Pete R., Kandel, Saugat, Parraga, Hannah, Rebuffi, Luca, Shi, Xianbo, Veseli, Siniša, Wolfman, Mark, Wyman, Max, Zhou, Tao, Chard, Ryan, Cote, Benoit, Allcock, William, Assoufid, Lahsen, Cherukara, Mathew J., Kelly, Shelly, Sandy, Alec, Sullivan, Joseph, and Schwarz, Nicholas
Subjects: *SCIENTIFIC knowledge, *SUPERCOMPUTERS, *ACQUISITION of data, *REAL-time computing, *DATA analysis, *ONLINE data processing
Abstract: The article discusses the ongoing upgrade of the Advanced Photon Source (APS) and the implementation of advanced computational technologies for experiment control, data acquisition, and data analysis. The upgrade aims to make the APS the brightest hard X-ray synchrotron light source in the world. The article highlights the use of automated optics alignment and artificial intelligence/machine learning approaches for improved precision and efficiency in experiments. It also describes the development of a new control system for a spectroscopy beamline using Bluesky and Ophyd, which has already enabled user experiments during commissioning. The article emphasizes the importance of these advancements in handling the increasing volume of data generated at the APS and improving research opportunities. The APS is partnering with the Argonne Leadership Computing Facility (ALCF) to provide streamlined computing capabilities for researchers, including dedicated computing allocations and standardized processing workflows. The APS has also implemented a Fast Autonomous Scanning Toolkit (FAST) that uses neural networks and efficient hardware controls for scanning microscopy experiments. These advancements will enhance the capabilities of the APS and facilitate real-time data processing and analysis during experiments. [Extracted from the article]
Published: 2023
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877. 20 µs‐resolved high‐throughput X‐ray photon correlation spectroscopy on a 500k pixel detector enabled by data‐management workflow.

Author: Zhang, Qingteng, Dufresne, Eric M., Nakaye, Yasukazu, Jemian, Pete R., Sakumura, Takuto, Sakuma, Yasutaka, Ferrara, Joseph D., Maj, Piotr, Hassan, Asra, Bahadur, Divya, Ramakrishnan, Subramanian, Khan, Faisal, Veseli, Sinisa, Sandy, Alec R., Schwarz, Nicholas, and Narayanan, Suresh
Subjects: *LIGHT beating spectroscopy, *WORKFLOW, *DETECTORS, *X-rays, *WORKFLOW software, *PIXELS, *WORKFLOW management
Abstract: The performance of the new 52 kHz frame rate Rigaku XSPA‐500k detector was characterized on beamline 8‐ID‐I at the Advanced Photon Source at Argonne for X‐ray photon correlation spectroscopy (XPCS) applications. Due to the large data flow produced by this detector (0.2 PB of data per 24 h of continuous operation), a workflow system was deployed that uses the Advanced Photon Source data‐management (DM) system and high‐performance software to rapidly reduce area‐detector data to multi‐tau and two‐time correlation functions in near real time, providing human‐in‐the‐loop feedback to experimenters. The utility and performance of the workflow system are demonstrated via its application to a variety of small‐angle XPCS measurements acquired from different detectors in different XPCS measurement modalities. The XSPA‐500k detector, the software and the DM workflow system allow for the efficient acquisition and reduction of up to ∼109 area‐detector data frames per day, facilitating the application of XPCS to measuring samples with weak scattering and fast dynamics. [ABSTRACT FROM AUTHOR]
Published: 2021
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878. Bradyarrhythmias in patients with COVID‐19: Marker of poor prognosis?

Author: Chinitz, Jason S., Goyal, Rajat, Harding, Melissa, Veseli, Granit, Gruberg, Luis, Jadonath, Ram, Maccaro, Paul, Gandotra, Puneet, Ong, Lawrence, and Epstein, Laurence M.
Subjects: *BRADYCARDIA, *CARDIAC pacemakers, *TREATMENT effectiveness, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *COVID-19
Abstract: Background: Despite descriptions of various cardiovascular manifestations in patients with coronavirus disease 2019 (COVID‐19), there is a paucity of reports of new onset bradyarrhythmias, and the clinical implications of these events are unknown. Methods: Seven patients presented with or developed severe bradyarrhythmias requiring pacing support during the course of their COVID‐19 illness over a 6‐week period of peak COVID‐19 incidence. A retrospective review of their presentations and clinical course was performed. Results: Symptomatic high‐degree heart block was present on initial presentation in three of seven patients (43%), and four patients developed sinus arrest or paroxysmal high‐degree atrioventricular block. No patients in this series demonstrated left ventricular systolic dysfunction or acute cardiac injury, whereas all patients had elevated inflammatory markers. In some patients, bradyarrhythmias occurred prior to the onset of respiratory symptoms. Death from complications of COVID‐19 infection occurred in 57% (4/7) patients during the initial hospitalization and in 71% (5/7) patients within 3 months of presentation. Conclusions: Despite management of bradycardia with temporary (3/7) or permanent leadless pacemakers (4/7), there was a high rate of short‐term morbidity and death due to complications of COVID‐19. The association between new‐onset bradyarrhythmias and poor outcomes may influence management strategies for acutely ill patients with COVID‐19. [ABSTRACT FROM AUTHOR]
Published: 2020
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879. ELECTRICITY TRADING VIA BLOCKCHAIN IN AN ENERGY COMMUNITY FROM A DATA PROTECTION POINT OF VIEW.

Author: Holzleitner, Marie-Theres, Burgstaller, Katrin, Cejka, Stephan, and Veseli, Argjenta
Subjects: *DATA protection, *BLOCKCHAINS, *GENERAL Data Protection Regulation, 2016, *ELECTRIC power consumption, *ELECTRONIC data processing, *ELECTRICITY
Abstract: As the civilian population is no longer just a consumer, but also a producer of renewable energy (so-called prosumer), the electricity consumption data between the members need a tamper-proof and automatic billing system. The blockchain technology can be used for trading electricity in an energy community and aims at making the system smarter. It can manage the billing between the members, i.e., the energy producers (e.g. power generated by a PV system), the energy consumers, and/or those involved as energy storage. The processing of data by means of a blockchain can be helpful, but there is an inherent conflict with questions of data protection, especially since data on the energy consumption of households is considered as personal data. The General Data Protection Regulation (hereafter GDPR) is the EU's most comprehensive instrument to date for protecting the personal data of its citizens. The advantage of blockchains is that data is stored on many concatenated blocks that cannot be modified after their creation, which makes manipulation impossible and creates trust. Thus, there is a balancing act between the protection of personal data and the advantages of blockchain technology. [ABSTRACT FROM AUTHOR]
Published: 2020
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880. A cryptic plasmid is among the most numerous genetic elements in the human gut.

Author: Fogarty, Emily C., Schechter, Matthew S., Lolans, Karen, Sheahan, Madeline L., Veseli, Iva, Moore, Ryan M., Kiefl, Evan, Moody, Thomas, Rice, Phoebe A., Yu, Michael K., Mimee, Mark, Chang, Eugene B., Ruscheweyh, Hans-Joachim, Sunagawa, Shinichi, Mclellan, Sandra L., Willis, Amy D., Comstock, Laurie E., and Eren, A. Murat
Subjects: *FECAL contamination, *GUT microbiome, *HORIZONTAL gene transfer, *MOBILE genetic elements, *INFLAMMATION, *INFLAMMATORY bowel diseases
Abstract: Plasmids are extrachromosomal genetic elements that often encode fitness-enhancing features. However, many bacteria carry "cryptic" plasmids that do not confer clear beneficial functions. We identified one such cryptic plasmid, pBI143, which is ubiquitous across industrialized gut microbiomes and is 14 times as numerous as crAssphage, currently established as the most abundant extrachromosomal genetic element in the human gut. The majority of mutations in pBI143 accumulate in specific positions across thousands of metagenomes, indicating strong purifying selection. pBI143 is monoclonal in most individuals, likely due to the priority effect of the version first acquired, often from one's mother. pBI143 can transfer between Bacteroidales, and although it does not appear to impact bacterial host fitness in vivo , it can transiently acquire additional genetic content. We identified important practical applications of pBI143, including its use in identifying human fecal contamination and its potential as an alternative approach to track human colonic inflammatory states. [Display omitted] • pBI143 is a cryptic plasmid that is prevalent in industrialized human populations • pBI143 is only ∼2.7 kb, yet it regularly makes up over 0.1% of gut metagenomic reads • The naive 2-gene form appears parasitic, but pBI143 can carry additional genes • The relative copy number of pBI143 increases during stress, including in IBD A widely distributed and highly conserved human gut plasmid is extremely numerous in industrialized human gut metagenomes and increases its copy number in response to stress. [ABSTRACT FROM AUTHOR]
Published: 2024
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881. Comprehensive UHPLC–MS screening methods for the analysis of triazolopyrazine precursor and its genotoxic nitroso-derivative in sitagliptin pharmaceutical formulation.

Author: Jireš, Jakub, Douša, Michal, Gibala, Petr, Doubský, Jan, Pěček, Daniel, Mervart, David, Kluk, Anna, Veseli, Ardita, Kalášek, Stanislav, and Řezanka, Pavel
Subjects: *NITROSOAMINES, *LIQUID chromatography-mass spectrometry, *INTELLECTUAL property, *HYDROPHILIC interaction liquid chromatography, *SITAGLIPTIN, *QUADRUPOLE ion trap mass spectrometry, *SCIENTIFIC literature
Abstract: A case study on Sitagliptin drug products and Sitagliptin/Metformin drug products concerning contamination with N -nitrosamines was performed using two newly developed analytical methods for determination of N -nitroso-triazolopyrazine (NTTP; 7-nitroso-3-(trifluoromethyl)–5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3- a ]pyrazine) and its precursor triazolopyrazine (3-(trifluoromethyl)–5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3- a ]pyrazine). The method for determination of triazolopyrazine was previously unpublished, the method for determination of NTTP was published only for analysis of active pharmaceutical ingredient Sitagliptin and not the drug forms. Solving the N -nitrosamine contamination is requested by regulatory authorities all over the world and thus is vital for all pharmaceutical companies. The solution always requires a sensitive analytical method. Both newly developed methods use liquid chromatography coupled with mass spectrometry (single quadrupole analyzer in case of triazolopyrazine and triple quadrupole analyzer in case of NTTP). Separation of triazolopyrazine was achieved on a column Acquity CSH C18 using a mobile phase consisting of aqueous ammonium formate buffered at pH 4.2 and acetonitrile. Detection was performed using positive electrospray and selected ion monitoring at m/z 193. Separation of NTTP was achieved on a column Acquity HSS T3 using a mobile phase consisting of 0.1 % formic acid in water and methanol. Detection was performed using positive electrospray and multiple reaction monitoring at transitions m / z 222.15→42.05 (collision energy 17 eV) and m / z 222.15→192.15 (collision energy 11 eV). Two issues specific to NTTP and triazolopyrazine previously not described in scientific literature were successfully troubleshooted. Spontaneous degradation of Sitagliptin to triazolopyrazine and methyl (R)–3-amino-4-(2,4,5-trifluorophenyl)butanoate was solved by using N,N -dimethylformamide as sample solvent during development of the method for quantitation of triazolopyrazine. A bad peak shape of NTTP due to the presence of rotamers of NTTP was successfully troubleshooted by increasing column temperature. Both methods were used during an optimization study of manufacturing of Sitagliptin and Sitagliptin/Metformin drug products. The goal of the study was to decrease NTTP content in the final drug product under the strict legislative limit set by Federal Drug Agency. The efficacy of several solutions was proven, but could not be fully disclosed due to Intellectual Property Protection policy of Zentiva. Instead, a brief review of recently published strategies to cope with N -nitrosamine contamination is presented. [Display omitted] • N -Nitroso-triazolopyrazine (NTTP) – a new genotoxic impurity present in Sitagliptin. • LC-MS/MS method for quantification of NTTP was developed and validated. • Presence of rotamers and degradation were observed and successfully troubleshooted. • Screening of N -nitroso-triazolopyrazine and its precursor was performed. [ABSTRACT FROM AUTHOR]
Published: 2024
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882. Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability and reduces myocardial infarction in mice.

Author: Roth, Lynn, Van der Donckt, Carole, Emini Veseli, Besa, Van Dam, Debby, De Deyn, Peter P., Martinet, Wim, Herman, Arnold G., and De Meyer, Guido R.Y.
Subjects: *ATHEROSCLEROTIC plaque, *MICE, *MYOCARDIAL infarction, *NITRIC oxide, *CORONARY disease, *APOLIPOPROTEIN E
Abstract: Nitric oxide (NO) donors are commonly used for the prevention and treatment of ischemic heart disease. Besides their effects on the heart, NO donors may also prevent hypoxic brain damage and exert beneficial effects on atherosclerosis by favoring features of plaque stability. We recently described that apolipoprotein E (ApoE) deficient mice with a mutation in the fibrillin-1 (Fbn1) gene (ApoE -/- Fbn1 C1039G+/- ) develop accelerated atherosclerosis, plaque rupture, myocardial infarction, cerebral hypoxia and sudden death. In the present study, we evaluated the effects of chronic treatment with the NO donor molsidomine on atherosclerotic plaque stability, cardiac function, neurological symptoms and survival in the ApoE -/- Fbn1 C1039G+/- mouse model. Female ApoE -/- Fbn1 C1039G+/ - mice were fed a Western diet (WD). After 8 weeks of WD, the mice were divided into two groups receiving either molsidomine via the drinking water (1 mg/kg/day; n = 34) or tap water (control; n = 36) until 25 weeks of WD. Survival tended to increase after molsidomine treatment (68% vs. 58% in controls). Importantly, atherosclerotic plaques of molsidomine-treated mice had a thicker fibrous cap (11.1 ± 1.2 vs. 8.1 ± 0.7 μm) and showed an increased occurrence of plaque macrocalcifications (30% vs. 0%), indicative of a more stable phenotype. Molsidomine also improved cardiac function, as fractional shortening was increased (40 ± 2% vs. 27 ± 2%) combined with a decreased end diastolic (3.1 ± 0.2 vs. 3.9 ± 0.2 mm) and end systolic diameter (1.9 ± 0.1 vs. 2.9 ± 0.2 mm). Furthermore, perivascular fibrosis (23 ± 2 vs. 30 ± 2%) and the occurrence of myocardial infarctions (12% vs. 36%) was significantly reduced. Track width, a measure of the animal's hind limb base of support and representative of hypoxic brain damage, was also normalized as a result of molsidomine treatment (2.54 ± 0.04 vs. 2.91 ± 0.09 cm in controls). These findings demonstrate that the NO donor molsidomine improves cardiac function, reduces neurological symptoms and enhances atherosclerotic plaque stability. Unlabelled Image [ABSTRACT FROM AUTHOR]
Published: 2019
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883. PvaPy: Python API for EPICS PV Access

Author: Veseli, S.
Published: 2016
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884. LOCALLY INDUCED FOCAL IDIOPATHIC VENTRICULAR TACHYCARDIA.

Author: Kaul, Risheek, Hoch, Ethan Gregory, Jin, Chengyue, Veseli, Granit, Rojas, Rhadames, Frenkel, Daniel, Iwai, Sei, and Jacobson, Jason T.
Subjects: *VENTRICULAR tachycardia
Published: 2022
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885. Semileptonic form factors: A model-independent approach

Author: Veseli, Sinisa
Published: 2001
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886. From scalar to string confinement

Author: Veseli, Sinisa
Published: 2000
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887. The SAM-Grid Fabric services

Author: Garzoglio, G., Terekhov, I., Baranovski, A., Veseli, S., Lueking, L., Mhashilkar, P., and Murthi, V.
Subjects: *DISTRIBUTED computing, *COMPUTERS, *COMPUTER network architectures, *MICROPROCESSORS
Abstract: Abstract: To enable globally distributed computing for a large HEP experiment, a collection of computing and data storage facilities, together called the Grid fabric, must be linked together in a coherent way. The standard Grid software, including most notably the Globus Gatekeeper and Meta Directory Service, provides core tools to insert a site into the Grid and for its low-level monitoring. In practice, large experiments have data and job handling infrastructures that are not governed by the core tools. For example, local job submission is seldom done directly to the batch system, but rather, through an interface that allows for pre-submission steps (such as the decomposition of a job into smaller chunks) or is tightly integrated with a data handling system such as SAM. Likewise, monitoring is seldom done in terms of individual processors or individual jobs, but rather, via cluster-wide aggregated characteristics. In this paper, we present some of the work we have done to abstract the management of the fabric facilities of the FNAL Run II experiments, in order to enable globally distributed computing. [Copyright &y& Elsevier]
Published: 2004
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888. Distinguishing WH and Wb{bar b} production at the Fermilab Tevatron

Author: Veseli, S [Theoretical Physics Department, Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, Illinois 60510 (United States)]
Published: 1999
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889. Curved QCD string dynamics

Author: Veseli, S [Theoretical Physics Department, Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, Illinois 60510 (United States)]
Published: 1999
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890. Asymmetric flux tube

Author: Veseli, S [Department of Physics, University of Wisconsin, Madison, Wisconsin 53706 (United States)]
Published: 1995
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891. Relativistic flux tube model calculation of the Isgur-Wise function

Author: Veseli, S [Department of Physics, University of Wisconsin, Madison, Wisconsin 53706 (United States)]
Published: 1995
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892. The SAM-GRID project: architecture and plan

Author: Baranovski, A., Garzoglio, G., Koutaniemi, H., Lueking, L., Patil, S., Pordes, R., Rana, A., Terekhov, I., Veseli, S., Yu, J., Walker, R., and White, V.
Subjects: *ELECTRONIC file management, *DATA analysis
Abstract: SAM is a robust distributed file-based data management and access service, fully integrated with the D0 experiment at Fermilab and in phase of evaluation at the CDF experiment. The goal of the SAM-Grid project is to fully enable distributed computing for the experiments. The architecture of the project is composed of three primary functional blocks: the job handling, data handling, and monitoring and information services. Job handling and monitoring/information services are built on top of standard grid technologies (Condor-G/Globus Toolkit), which are integrated with the data handling system provided by SAM. The plan is devised to provide the users incrementally increasing levels of capability over the next 2 years. [Copyright &y& Elsevier]
Published: 2003
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893. Quantitative Analysis of Economic Performance in the European Space Industry: Project 'Analysis of the European Space Industry' mandated by the European Space Agency - Directorate of Technical and Quality Management

Author: Arvanitis, Spyridon, Wörter, Martin, Veseli, Tim, Frener, Arlette, and Stucki, Tobias
Subjects: ASTRONAUTICAL ENGINEERING, RAUMFAHRTTECHNIK, Economics, TECHNOLOGISCHE UND WISSENSCHAFTLICHE INNOVATIONEN, ddc:330, INDUSTRIEUNTERNEHMEN, INDUSTRIAL COMPANIES, TECHNOLOGICAL AND SCIENTIFIC INNOVATIONS, EU-Staaten, Innovation, Weltraumtechnik
Abstract: KOF Studies, 50
Published: 2014

894. Branchenstrukturbericht grafische Industrie

Author: Iselin, David, Konjunkturforschungsstelle Zürich, and Veseli, Kushtrim
Subjects: MARKTFORSCHUNG, Economics, Schweiz, SCHRIFTTYPEN UND DRUCKTYPEN (DRUCKEREIWESEN), PRINTING TYPES (PRINTING), ddc:330, Branchenentwicklung, GRAFIKDESIGN + VISUELLE KOMMUNIKATION + WERBEGRAFIK, GRAPHIC DESIGN + VISUAL COMMUNICATION + ADVERTISING ART, MARKET RESEARCH, Druckindustrie
Abstract: Die KOF hat für den Branchenverband VISCOM und die Gewerkschaft Syndicom eine Umfrage bei den Unternehmen der grafischen Industrie durchgeführt. Die Schweizer Unternehmen der grafischen Industrie haben zwar unter der jüngsten Rezession gelitten, für die Zukunft erwarten sie aber eine Verbesserung ihrer Situation. Dies bezieht sich sowohl auf die Entwicklung des Umsatzes, der Nachfrage wie auch der Beschäftigten. Die Unternehmen schätzen den Preisdruck, der weder vor lokalen, regionalen noch nationalen Grenzen Halt macht, als sehr stark ein. Dies zwingt die Unternehmen, sich über nicht-preisliche Faktoren zu positionieren. Daneben werden auch Teile des Produktionsprozesses ausgelagert. Eine Verschiebung zeichnet sich beim Arbeitskräftebedarf ab. Hier dürften in Zukunft höhere Qualifikationen wichtiger werden. Entsprechend müssten die Weiterbildungsangebote angepasst werden, mit denen nicht alle Unternehmen zufrieden sind. Relativ häufig sind Änderungswünsche am Gesamtarbeitsvertrag (GAV), wobei aber aus den Fragen nicht ersichtlich wird, in welche Richtung sich dieser entwickeln sollte., KOF Studies, 28
Published: 2011

895. Artificial tongue: a promising solution for early detection and treatment of oral bacterial infections.

Author: Veseli E, Behluli E, Breznica E, and Veseli A
Subjects: Humans, Early Diagnosis, Bacterial Infections diagnosis, Bacterial Infections drug therapy, Mouth Diseases microbiology, Mouth Diseases diagnosis, Tongue microbiology
Published: 2024
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896. Dementia and AI.

Author: Veseli E, Veseli A, and Tovani-Palone MR
Subjects: Humans, Dementia, Artificial Intelligence
Published: 2024
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897. Evaluation of oral health status in pregnant women and its correlation with calcium and phosphate levels.

Author: Behluli E, Veseli E, and Veseli A
Subjects: Humans, Female, Pregnancy, Adult, Young Adult, DMF Index, Pregnancy Complications blood, Pregnancy Complications epidemiology, Oral Health, Phosphates blood, Phosphates analysis, Calcium blood
Abstract: Aim: This study aimed to analyze the oral health conditions of pregnant women. The analysis involves evaluating two key indices: the decayed, missing, and filled teeth (DMFT) index and the basic erosive wear examination (BEWE) index. Furthermore, this study investigated potential correlations between calcium (Ca) and phosphate (P) levels within specific time intervals and the aforementioned oral health indices., (This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Published: 2024
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898. Blood group AB is associated with reduced blood loss but also elevated cardiovascular mortality in aortocoronary bypass surgery.

Author: Masseli F, Veseli A, Pfohl M, Hoch J, Treede H, and Schiller W
Subjects: Humans, Coronary Artery Bypass adverse effects, Hemorrhage etiology, Treatment Outcome, Myocardial Ischemia etiology, Coronary Artery Disease complications, Heart Diseases etiology, Blood Group Antigens
Abstract: Patient blood group (BG) is predictive for von-Willebrand-factor (VWF) and Factor VIII variation. The clinical impact of this ABO-effect on blood loss, cardiovascular complications and outcome has been described for several patient cohorts. The aim of this study was to investigate the impact of patient BG on blood loss and outcome after coronary artery bypass surgery (CABG). Patient records, intraoperative data and perioperative transfusion records of 5713 patients receiving an on-pump CABG procedure between 05/2004 and 12/2018 were analyzed. A logistic regression model for death due to perioperative myocardial ischaemia (PMI) was developed from initially 24 variables by using an univariate and multivariate selection process. BG AB patients required less blood transfusions as compared to the other blood groups, especially in case of emergency operations. However, BG AB patients also had a higher mortality which was due to secondary cardiovascular complications. The impact of blood type on the rate of cardiovascular mortality was confirmed in the logistic regression model. BG AB patients have a worse outcome after CABG surgery due to an increased incidence of fatal cardiovascular complications. As perioperative myocardial ischemia due to graft occlusion appears to be the most likely explanation, stricter anticoagulation for BG AB patients should be discussed., (© 2024. The Author(s).)
Published: 2024
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899. Should ChatGPT Have Some Applicability in the Management of Emergency Dental Care for Emigrant Adults and Children?

Author: Veseli E, Tovani-Palone MR, Veseli A, and Kastrati L
Subjects: Adult, Child, Humans, Dental Care, Artificial Intelligence, Emergency Medical Services
Abstract: How to cite this article: Veseli E, Tovani-Palone MR, Veseli A, et al . Should ChatGPT Have Some Applicability in the Management of Emergency Dental Care for Emigrant Adults and Children? J Contemp Dent Pract 2023;24(11):819-820. Keywords: Artificial intelligence, Dental care, Dentistry, Emigrants and immigrants, Public health.
Published: 2023
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900. A review of methods for solubility determination in biopharmaceutical drug characterization.

Author: Veseli A, Žakelj S, and Kristl A
Subjects: Solubility, Thermodynamics, Biological Products chemistry, Chemistry, Pharmaceutical methods
Abstract: The significance of thermodynamic solubility in biopharmaceutical compound or drug characterization as well as the importance of having methods that accurately establish it have been extensively addressed. Nonetheless, its precise determination continues to remain a challenging task to accomplish. Even more so when the number of compounds to evaluate is high and the available amount of each compound is low, both of which are inevitable for the compound characterization during the drug development process. Except for the shake-flask method which is still considered as the 'gold standard' in obtaining thermodynamic data, it is currently difficult to say that another satisfactory model which is routinely used to determine thermodynamic solubility is being applied. Therefore, this review summarizes the various experimental approaches which are based on the classical shake flask method but have yet attempted to speed up the experimental process of obtaining such data more conveniently. The most important experimental features of these approaches are provided to the reader. Some advantages and disadvantages associated with each approach are also highlighted, consequently offering a resource to those looking for the most appropriate of the approaches that have already fared well at determining the biopharmaceutically relevant drug solubility.
Published: 2019
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