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67. Extended Resections for Advanced Gallbladder Cancer: Results from a Nationwide Cohort Study

Author

Kuipers, H., primary, de Savornin Lohman, E. A. J., additional, van Dooren, M., additional, Braat, A. E., additional, Daams, F., additional, van Dam, R., additional, Erdmann, J. I., additional, Hagendoorn, J., additional, Hoogwater, F. J. H., additional, Groot Koerkamp, B., additional, van Gulik, T. M., additional, de Reuver, P. R., additional, and de Boer, M. T., additional

Published
2020
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68. Volume–outcome relationship of liver surgery: a nationwide analysis

Author

Olthof, P B, primary, Elfrink, A K E, additional, Marra, E, additional, Belt, E J T, additional, van den Boezem, P B, additional, Bosscha, K, additional, Consten, E C J, additional, den Dulk, M, additional, Gobardhan, P D, additional, Hagendoorn, J, additional, van Heek, T N T, additional, IJzermans, J N M, additional, Klaase, J M, additional, Kuhlmann, K F D, additional, Leclercq, W K G, additional, Liem, M S L, additional, Manusama, E R, additional, Marsman, H A, additional, Mieog, J S D, additional, Oosterling, S J, additional, Patijn, G A, additional, te Riele, W, additional, Swijnenburg, R-J, additional, Torrenga, H, additional, van Duijvendijk, P, additional, Vermaas, M, additional, Kok, N F M, additional, Grünhagen, D J, additional, Besselink, M G H, additional, de Boer, M T, additional, Buis, C I, additional, van Gulik, T M, additional, Hoogwater, F J H, additional, Molenaar, I Q, additional, Dejong, C H C, additional, and Verhoef, C, additional

Published
2020
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72. Reply

Author

Snoeren, N., Jansen, M. C., ten Kate, F. J.W., and van Gulik, T. M.

Published
2009
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81. Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) : An International Multicenter Analysis

Author

Klompmaker, S., Peters, N. A., van Hilst, J., Bassi, C., Boggi, U., Busch, O. R., Niesen, W., Van Gulik, T. M., Javed, A. A., Kleeff, J., Kawai, M., Lesurtel, M., Lombardo, C., Moser, A. J., Okada, K. -I., Popescu, I., Prasad, R., Salvia, R., Sauvanet, A., Sturesson, C., Weiss, M. J., Zeh, H. J., Zureikat, A. H., Yamaue, H., Wolfgang, C. L., Hogg, M. E., Besselink, M. G., Gerritsen, S. L., Adham, M., Albiol Quer, M. T., Berrevoet, F., Cesaretti, M., Dalla Valle, R., Darnis, B., Diener, M. K., Del Chiaro, M., Hackert, T. H., Grutzmann, R., Dumitrascu, T., Friess, H., Hirono, S., Ivanecz, A., Karayiannakis, A., Fusai, G. K., Labori, K. J., Lopez-Ben, S., Mabrut, J. -Y., Miyazawa, M., Pardo, F., Perinel, J., Roeyen, G., Graduate School, CCA - Cancer Treatment and Quality of Life, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, AGEM - Endocrinology, metabolism and nutrition, Surgery, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and E-AHPBA DP-CAR Study Grp

Subjects
Male, medicine.medical_specialty, Pancreatic Neoplasms/pathology, SURGERY, medicine.medical_treatment, Pancreatectomy/mortality, Pancreatectomy, Celiac artery, Celiac Artery, Pancreatic cancer, medicine.artery, Medicine and Health Sciences, Aged, Female, Follow-Up Studies, Humans, Middle Aged, Pancreatic Neoplasms, Retrospective Studies, Survival Rate, Treatment Outcome, Patient Selection, Journal Article, Medicine, Survival rate, ARTERY, Framingham Risk Score, business.industry, Mortality rate, Celiac Artery/surgery, ADENOCARCINOMA, Retrospective cohort study, medicine.disease, Surgery, ddc, MODEL, Multicenter Study, DEFINITION, Oncology, Hepatobiliary Tumors, VOLUME, Adenocarcinoma, Human medicine, business
Abstract

Background Distal pancreatectomy with celiac axis resection (DP-CAR) is a treatment option for selected patients with pancreatic cancer involving the celiac axis. A recent multicenter European study reported a 90-day mortality rate of 16%, highlighting the importance of patient selection. The authors constructed a risk score to predict 90-day mortality and assessed oncologic outcomes. Methods This multicenter retrospective cohort study investigated patients undergoing DP-CAR at 20 European centers from 12 countries (model design 2000–2016) and three very-high-volume international centers in the United States and Japan (model validation 2004–2017). The area under receiver operator curve (AUC) and calibration plots were used for validation of the 90-day mortality risk model. Secondary outcomes included resection margin status, adjuvant therapy, and survival. Results For 191 DP-CAR patients, the 90-day mortality rate was 5.5% (95 confidence interval [CI], 2.2–11%) at 5 high-volume (≥ 1 DP-CAR/year) and 18% (95 CI, 9–30%) at 18 low-volume DP-CAR centers (P = 0.015). A risk score with age, sex, body mass index (BMI), American Society of Anesthesiologists (ASA) score, multivisceral resection, open versus minimally invasive surgery, and low- versus high-volume center performed well in both the design and validation cohorts (AUC, 0.79 vs 0.74; P = 0.642). For 174 patients with pancreatic ductal adenocarcinoma, the R0 resection rate was 60%, neoadjuvant and adjuvant therapies were applied for respectively 69% and 67% of the patients, and the median overall survival period was 19 months (95 CI, 15–25 months). Conclusions When performed for selected patients at high-volume centers, DP-CAR is associated with acceptable 90-day mortality and overall survival. The authors propose a 90-day mortality risk score to improve patient selection and outcomes, with DP-CAR volume as the dominant predictor. Electronic supplementary material The online version of this article (10.1245/s10434-018-07101-0) contains supplementary material, which is available to authorized users.

Published
2019

90. Trends in Treatment and Survival of Gallbladder Cancer in the Netherlands; Identifying Gaps and Opportunities from a Nation-Wide Cohort

Author

Lohman, ED, de Bitter, T, Verhoeven, R, van der Geest, L, Hagendoorn, J, Mohammad, NH, Daams, F, Klumpen, HJ, van Gulik, T, Erdmann, J, Boer, M, Hoogwater, F, Groot Koerkamp, B, Braat, A, Verheij, J, Nagtegaal, I, van Laarhoven, C, van den Boezem, P, Post, R, de Reuver, P, Lohman, ED, de Bitter, T, Verhoeven, R, van der Geest, L, Hagendoorn, J, Mohammad, NH, Daams, F, Klumpen, HJ, van Gulik, T, Erdmann, J, Boer, M, Hoogwater, F, Groot Koerkamp, B, Braat, A, Verheij, J, Nagtegaal, I, van Laarhoven, C, van den Boezem, P, Post, R, and de Reuver, P

Published
2020

91. Advances in adjuvant therapy of biliary tract cancer: an overview of current clinical evidence based on phase II and III trials

Author

MS Medische Oncologie, Cancer, MS CGO, Externen Med. Onco, Belkouz, A, Wilmink, J W, Haj Mohammad, N, Hagendoorn, J, de Vos-Geelen, J, Dejong, C H C, Homs, M Y V, Groot Koerkamp, B, van Gulik, T M, van Oijen, M G H, Punt, C J A, Klümpen, H, MS Medische Oncologie, Cancer, MS CGO, Externen Med. Onco, Belkouz, A, Wilmink, J W, Haj Mohammad, N, Hagendoorn, J, de Vos-Geelen, J, Dejong, C H C, Homs, M Y V, Groot Koerkamp, B, van Gulik, T M, van Oijen, M G H, Punt, C J A, and Klümpen, H

Published
2020

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