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Background: Multiple algorithms exist for treating acute primary upper extremity deep venous thrombosis (pUEDVT) caused by venous thoracic outlet syndrome (VTOS). In this case series, we present the results of our dedicated same admission treatment algorithm.Methods: All patients between January 2015 and December 2019 with an established acute upper extremity deep venous thrombosis (symptoms

The incidence of neurogenic thoracic outlet syndrome is completely unknown, and has been wildly overestimated in the past. Based on a prospectively maintained database at our academic Thoracic Outlet Center, we estimate the yearly incidence of neurogenic and venous thoracic outlet syndrome to be approximately 3 and 1 per 100,000 population, respectively. The ratio of neurogenic to venous thoracic outlet syndrome seems to be approximately 80:20 based on presentation, and 75:25 based on operative correction. These data will help to understand the impact of these disorders, and perhaps help to guide resource management.

Thoracic outlet syndrome is a condition of compression involving the brachial plexus and subclavian vessels. Although there are multiple surgical approaches to address thoracic outlet decompression, supraclavicular first rib resection with scalenectomy and brachial plexus neurolysis allow for complete exposure of the first rib, brachial plexus, and vasculature. This technique is described in detail. This approach is safe and can produce excellent outcomes in all variants of thoracic outlet syndrome.

Background Thoracic outlet syndrome (TOS) refers to a constellation of compressive problems that occur at the thoracic outlet. TOS has been recognized since the 19th century, and the “modern” era of treatment, especially for neurogenic TOS, dates from at least the 1970s. Despite this, however, the incidence and prevalence of these syndromes are almost completely unknown. To attempt to answer this fundamental question, we established a prospective database of all patients who presented to our clinic with a diagnosis of potential TOS, as described below. Methods We established a database of all patients referred to our clinic from July 1, 2014 to May 2018. All subjective data, the tentative diagnosis, and plan at the time of the office visit were prospectively recorded. For patients with neurogenic TOS (NTOS), a standardized workup sheet was used based on the Society for Vascular Surgery's recently published reporting standards document. For patients with venous TOS (VTOS), diagnosis was made by clinical examination and ultrasound, and for those with arterial TOS (ATOS), by clinical examination, ultrasound, and cross-sectional imaging when needed. Results From July 1, 2014, to May 1, 2018, 526 patients were referred to our institution with a diagnosis of possible TOS. Of these, 432 (82%) were referred with symptoms suggestive of NTOS, 84 (16%) with symptoms suggestive of VTOS, and 10 (2%) with findings and/or symptoms suggestive of ATOS. NTOS: After evaluation as per the algorithm previously mentioned, 234 patients (54%) were judged high suspicion for NTOS, 126 (30%) moderate suspicion, and 72 (17%) low suspicion; 360 (83%) of those originally referred were felt to potentially have NTOS. Of the 84 patients with VTOS, 25 (30%) presented with acute Paget-Schroetter syndrome, 41 (48%) with subacute or chronic occlusion, and 18 (21%) with McCleery's syndrome. Finally, 8 of the 10 limbs had true ATOS; of these, 6 (75%) underwent decompression and repair and 2 (25%) endovascular intervention only. Based on referral assumptions and population density in our area, the incidence of NTOS seems to be between 2 and 3 cases per 100,000 people per year and that of VTOS between 0.5 and 1 per 100,000 people per year, ATOS being sporadic. The ratio of those with decent suspicion for NTOS and VTOS, respectively, is about 80:20, whereas that of those undergoing surgical decompression is about 75:25. Conclusions The rates of NTOS and VTOS, as aforementioned, are approximately 25 and 8 per year in a metropolitan area of 1,000,000, respectively. Although a rare disease, these numbers are not insignificant, although are much lower than prior estimates.

Objective Paget-Schroetter syndrome (PSS) is an uncommon disease with potentially debilitating long-term effects. The optimal therapy for PSS is unclear, and the role of surgical decompression of the thoracic outlet is still being questioned. In this study, we present long-term results of patients treated with catheter-directed thrombolysis (CDT) and anticoagulation without surgical management. Methods This is a retrospective case series of all patients who previously underwent treatment of PSS in our institution between the years 2007 and 2019. Patients were evaluated for clinical signs of post-thrombotic syndrome (PTS) using a modified Villalta scoring scale, including measurements of the circumference of the treated and untreated arms. Duplex ultrasound examination of the treated vein was performed, and quality of life was evaluated using the shortened Disabilities of the Arm, Shoulder, and Hand questionnaire. Results Eighteen consecutive patients previously treated for PSS with CDT and anticoagulation compose the cohort of this study. None underwent surgical thoracic outlet decompression. All were contacted and invited for clinical and ultrasound evaluation. Follow-up was available for all patients. Mean age at diagnosis was 29 years (range, 16-46 years), and 15 (79%) were male. Mean time from the index event to the follow-up clinic visit was 109 months (range, 37-176 months). Patients were treated with anticoagulation for a mean period of 26 months (range, 6-120 months). Seventeen patients (94%) had a Villalta score of 0 to 3, consistent with nonexistence of PTS. Fourteen patients (78%) were completely asymptomatic. Seven patients (39%) had no difference in arm circumference. A difference in arm circumference between the treated arm and the healthy arm of 1 cm and 2 cm was seen in nine (50%) and two (11%) patients, respectively. Based on the shortened Disabilities of the Arm, Shoulder, and Hand score, none of the patients suffered from impaired quality of life. Duplex ultrasound scanning of the affected veins was performed on 16 of the 18 patients (89%). The vein appeared patent in all examined patients. In three patients, the wall of the examined vein was thickened and irregular. Conclusions This study suggests that PSS patients can be treated with anticoagulation and CDT alone, without the need for surgical thoracic outlet decompression. This is based on long-term follow-up of these patients objectively evaluated by means of valid scoring systems. These findings suggest that symptoms or signs of PTS rarely develop, the patients do not suffer from impaired quality of life, and patency of the diseased vein is commonly maintained.

Aim: In this study, we aimed to evaluate the effectiveness of surgical treatment in patients diagnosed with thoracic outlet syndrome.Patients and Methods: This study was conducted by analyzing the age, sex, occupational distribution, anamnesis and physical examination findings, symptoms, preoperative examinations, operation findings, postoperative complications, postoperative hospital stay and operation results of thirty seven patients who were diagnosed with Thoracic Outlet Syndrome, and were operated on between 1991 and 2004.Results: Most of the patients were in the 15-35 age group (72.97%) and female (91.9%). Most of these cases were housewives (51.4%). The most common symptoms were pain (94.6%) and numbness (78.4%). The most commonly used test in physical examination was the Adson test, which provided an 86% positive rate. The most common pathology encountered in radiological tests was cervical rib anomaly (37.8%). It was found that EMG of upper extremity supported TOS with a rate of 48.6% and arterial doppler of upper extremity supported TOS with a rate of 13,5%. We applied first rib and cervical rib resection scalenectomy and cutting of fibromuscular bands as a surgery by transaxillary approach. A 78.4% complete recovery was observed in the early period after surgery and there was no mortality in any of the cases.Conclusion: In this study, the results were satisfactory in TOS patients on suitable cases and with good surgical technique. Surgical success rate can reach up to 97%. Amaç: Bu çalışmada, Torasik outlet sendromu tanısı konulan hastalarda cerrahi tedavinin etkinliğini değerlendirmeyi amaçladık.Hastalar ve Yöntem: 1991 ile 2004 yılları arasında Torasik Outlet Sendromu tanısı almış ve tedavi yöntemi olarak cerrahi uygulanmış otuz yedi olgunun yaş, cins, meslek dağılımı, anamnez ve fizik muayene bulguları, semptomları, preoperatif tetkikleri, operasyon bulguları, postoperatif komplikasyonları, postoperatif hastanede kalış süreleri ve operasyon sonuçlan incelenerek yapıldı.Bulgular: Olguların çoğu 15-35 yaş grubunda (% 72.97) ve kadınlardan (% 91,9) oluşmaktaydı. Bu olguların çoğu ev hanımıydı (% 51.4). En sık rastlanılan semptomlar ağrı (%94,6) ve uyuşma (% 78.4) idi. Fizik muayenede en sık kullanılan test Adson testi idi.Adson testi %86 oranında pozitif bulundu. Radyolojik testlerde en sık karşılaşılan patoloji servikal kosta anomalisiydi (% 37.8). üst ekstremite EMG sinin %48.6, üst ekstremite arteriel doplerinde% 13.5 oranında TOS u desteklediği bulundu. Cerrahide transaksiller girişim ile birinci kosta ve servikal kosta rezeksiyonu. skalenektomi fibromüsküler bantların kesilmesi işlemlerini uyguladık. Cerrahiden sonra erken dönemde %78.4 oranında tam düzelme görüldü. Olguların hiçbirinde mortalite olmadı.Sonuç: Bu çalışmada TOS hastalarda, uygun olgularda ve iyi cerrahi teknik ile sonuçlar tatmin edici bulundu. Cerrahi başarı oranı %97 lere kadar çıkabilmektedir.

Background Short-term outcomes in patients with all forms of TOS have been widely reported in the literature and have established that rib resection can be beneficial in decompressing the thoracic outlet and relieving pressure on traversing structures. We sought to determine long-term functional outcomes using the Disability of the Arm, Shoulder, and Hand (QuickDASH) survey in patients with TOS who underwent rib resection. Methods Clinical records for patients who underwent rib resection for TOS at a single institution were retrospectively reviewed. All patients were contacted via telephone and long-term functional outcome was assessed at latest follow-up via the 11-item version of the QuickDASH questionnaire. Demographics, TOS type, preoperative QuickDASH score, and athletic status were recorded. Patients were asked if they returned to baseline activity since their surgery, would have the procedure again, and if they were subjectively better postoperatively. Results From 2000 to 2018, 261 patients underwent rib resection surgery. One hundred seventy patients (65.1%) were able to be contacted via telephone for long-term follow-up. A total of 188 surgeries (102 neurogenic thoracic outlet syndrome, 82 venous thoracic outlet syndrome, 4 arterial thoracic outlet syndrome) were performed in these 170 patients. The mean follow-up time for the cohort was 5.3 years (range 1–18). Overall, 167 (88.9%) patients returned to baseline activity postoperatively. Postop QuickDASH decreased to 12 from 44 preoperatively for the cohort. Conclusions First rib resection and thoracic outlet decompression for all forms of TOS is a durable surgical treatment which results in excellent long-term functional outcomes as determined by both the QuickDASH score and subjective patient reporting.

Highlights • Neurovascular compression. • Non-standardized treatment. • Clinical, apparative tests., Thoracic outlet Syndrome (TOS) includes all disorders caused by compression of all neurovascular Structures in the upper thoracic outlet (Ross and Owners, 1966, Bürger and Arterien, 2014, Sanders and Annest, 2017). The Double-Crush-Syndrome (DBS) defines multilevel lesions along a neurovascular trunk caused by mechanical compression in different areas. Pectoralis-minor-syndrome (PMS) is also classified in the disorders of he upper thoracic outlet and was also known as hyperabductionsyndrome or subcoracoidal-syndrome. Between 2015–2019 our department treatet 488 patients suffering from neurological, vascular or combined TOS. Surgical treatment, depending on clinical and specific diagnostics was performed in 175 cases via transaxillary approach, including cervical rib resection, first rib resection, neurolysis of plexus brachialis, thoracal sympathectomy or vascular reconstruction. In all this year just a single patient with double crush syndrome was present. Case presentation and methods We report a case of a 28-years old female patient, reported in line with the SCARE criteria [13], suffering from neurvascular compression in the upper thoracic outlet after surgically treated clavicula fracture. She developed typical symptomes of a Thoracic Outlet Syndrome. Conclusion Double-Crush-Syndrome in patients with Thoracic Outlet Syndrome are very rare, case reports seldomly exist. The diagnosis requires a specific clinical testing and x-ray radiography. Furthermore dynamic tests like ultrasound and angiography and neurophysiological testing requires a high degree of experience, so the compressed area can be detected. Treatment includes an attempt of best medical and physical therapy, in case of failure a surgical treatment is necessary.

PURPOSE OF REVIEW: Neurovascular compression in the upper extremity is rare but can affect even those participating in high-level competitive athletics. To assess optimal approaches to treatment, in this review, we evaluate the current literature on neurovascular compressive syndromes affecting the upper extremity, with a special focus on the thoracic outlet syndrome (TOS). RECENT FINDINGS: Neurovascular compression at the thoracic outlet can involve the brachial plexus, subclavian artery, or subclavian vein, each with distinct clinical manifestations. Neurogenic TOS is best treated with surgical decompression, if physical therapy has not improved symptoms. Venous TOS results in acute thrombosis superimposed on chronic venous compression. Treatment is best directed at early anticoagulation, catheter-directed thrombolysis, and surgical decompression, with most patients able to discontinue anticoagulation and return to high-level athletic activity. Arterial TOS is related to aneurysmal degeneration of the subclavian artery with distal embolization, leading to limb-threatening ischemia. This should be aggressively treated with surgery. Similar degenerative changes can occur in the axillary artery and its branches, leading to distal embolization. Prompt recognition of these potential sources of limb-threatening ischemia is critical to limb preservation. SUMMARY: TOS includes rare but important conditions in the overhead athlete. Recent advances in physical therapy and image-guided diagnostic techniques have facilitated more accurate diagnosis. Surgical treatment remains the gold standard to maximize function or for limb preservation, and future research is needed to clarify optimal pain and physiotherapy regimens, as well as to examine novel approaches to neurovascular decompression.

Venous thoracic outlet syndrome (VTOS) is a compressive disorder of subclavian vein (SCV); we aimed to investigate the role of costoclavicular ligament (CCL) in the pathogenesis of VTOS. A cadaver study was carried out to investigate the presence and morphology of CCL in thoracic outlet regions, as well as its relationship with the SCV. Six formalin-fixed adult cadavers were included, generating 12 dissections of costoclavicular regions (two sides per cadaver). Once CCL was identified, observation and measurement were made of its morphology and dimensions, and its relationship with SCV was studied. To take a step further, a clinical VTOS case was reported to prove the anatomical findings. Two out of twelve costoclavicular regions (2/12, 16.7%) were found to possess CCLs. Both ligaments were located in the left side of two male cadavers and were closely attached to the lateral aspect of sternoclavicular joint capsules. The lateral fibers of the ligament proceed in a superolateral-to-inferomedial manner, while the medial fibers proceed more vertically. Both ligaments were tightly adherent to the SCV, causing significant compression on the vein. In the clinical case, multiple bunches of CCLs were found to compress the SCV tightly intraoperatively. After removing the ligaments, the patient’s symptom kept relief during a follow-up period of 2 years. Our study demonstrated that CCL could be a novel cause of VTOS by severe compression of SCV. Patients diagnosed with this etiology could get less invasive surgical treatment by simply removing the ligament.

Thoracic outlet syndrome (TOS) is the clinical entity that occurs with compression of the brachial plexus, subclavian artery, and/or subclavian vein at the superior thoracic outlet. Compression of each of these structures results in characteristic symptoms divided into three variants: neurogenic TOS, venous TOS, and arterial TOS, each arising from the specific structure that is compressed. The constellation of symptoms in each patient may vary, and patients may have more than one symptom simultaneously. Understanding the various anatomic spaces, causes of narrowing, and resulting neurovascular changes is important in choosing and interpreting radiological imaging performed to help diagnose TOS and plan for intervention. This publication has separated imaging appropriateness based on neurogenic, venous, or arterial symptoms, acknowledging that some patients may present with combined symptoms that may require more than one study to fully resolve. Additionally, in the postoperative setting, new symptoms may arise altering the need for specific imaging as compared to preoperative evaluation. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.

From 2015 to 2019, 9 patients underwent ultrasound-guided intranodal lymphangiography for the treatment of a chyle leak following thoracic outlet decompression surgery. Chyle leaks were identified by Lipiodol (Guerbet, Roissy, France) extravasation near the left supraclavicular surgical bed in all patients. The technical success rate of thoracic duct embolization was 67% (6 of 9), including fluoroscopic transabdominal antegrade access (n = 4) and ultrasound-guided retrograde access in the left neck (n = 2). Clinical success was achieved in 89% of patients (8 of 9). The mean interval from lymphangiography to drain removal was 6.6 days (range, 4–18 d). No patients had a chyle leak recurrence during clinical follow-up (mean, 304 d).

Background The treatment of venous thoracic outlet syndrome (VTOS) requires surgical decompression often combined with catheter-directed thrombolysis and venoplasty. Surgical options include transaxillary, supraclavicular, or infraclavicular approaches to first rib resection. The optimal method, however, has yet to be defined. The purpose of this study is to compare the outcomes of patients who underwent infraclavicular versus supraclavicular surgical decompression for VTOS. Methods A retrospective review of patients who underwent surgical management for VTOS from December 2010 to November 2017 was performed. During the study period, supraclavicular and infraclavicular approaches were chosen according to surgeon preference. Patient demographics, pre- and postdecompression interventions, perioperative outcomes for each group of patients were analyzed. Results Thirty patients underwent surgical management of VTOS, of which 15 (50%) underwent infraclavicular decompression and 15 (50%) supraclavicular decompression. The mean age of patients was 32.1 ± 13.6 years and 80% were male. Twenty-six patients (86.7%) presented with thrombotic VTOS. Acute axillosubclavian vein thrombosis was present in 20 (76.9%) of these patients, 10 patients in each group. Subacute or chronic thrombosis was encountered in the remaining 6 (23%) patients, 2 patients in the infraclavicular group and 4 patients in the supraclavicular group. Preoperative thrombolysis was utilized in 7 (46.7%) and 6 (40%) patients in the infraclavicular and supraclavicular groups, respectively (P = 1.00). Patients without postdecompression venography were removed from analysis and included 1 patient in the infraclavicular group and 5 patients in the supraclavicular group. Initial postdecompression venogram, prior to any endovascular intervention, demonstrated a residual axillosubclavian vein stenosis of greater than 50% in 6 (42.9%) patients in the infraclavicular decompression group and 7 (70%) patients in the supraclavicular decompression group (P = 0.24). Crossing the stenosis after surgical decompression was more easily accomplished in the infraclavicular group, 14 (100%) versus 5 (50%), (P = 0.01). Following endovascular venoplasty, calculated residual stenosis greater than 50% was found in 0 (0%) and 3 (30%) patients in the infraclavicular and supraclavicular approaches, respectively (P = 0.047). Infraclavicular thoracic outlet decompression was associated with fewer patients with postoperative symptoms, 0 of 15 (0%) versus 8 of 15 (53.3%), (P = 0.0022), and infraclavicular thoracic outlet decompression demonstrated improved patency, 15 of 15 (100%) versus 8 of 15 (53.3%), (P = 0.028) at a mean combined follow-up of 8.47 ± 10.8 months. Conclusions Infraclavicular thoracic outlet decompression for the surgical management of VTOS was associated with fewer postoperative symptoms and improved axillosubclavian vein patency compared to the supraclavicular approach. Prospective analysis is warranted to determine long-term outcomes following infraclavicular decompression.

ObjectivesScarring from prior bypass surgery and irradiation may compromise revascularization options in critical ischemia due to underlying occlusive disease. Occlusive disease of the axillo-brachial artery is particularly difficult to revascularize under such hostile conditions.MethodWe present a case of a 58-year-old woman presenting with a painful, pulseless, and cool left upper extremity. The patient had a known history of left upper extremity occlusive disease which was managed by subclavian–axillary artery stenting with re-occlusion and subsequent extra-anatomic left carotid-to-proximal brachial artery prosthetic bypass, which was complicated by stroke. The patient had a history of left mastectomy, axillary node dissection, and external beam radiation therapy. When considering revascularization options, the combination of post-radiation changes and scarring of the conventional operative zones for revascularization posed a high risk for complications. We describe a novel approach for such revascularization, where the inflow source was the terminal brachiocephalic artery, outflow to the upper left brachial artery, with anatomic intrathoracic-to-axillary tunneling through the thoracic outlet after verifying the lack of dynamic extrinsic compression at that level.ResultThe procedure resulted in resolution of the symptoms and the patient continued to do well 2 years later.ConclusionThis case shows that anatomic tunneling through the thoracic outlet can be a viable option for upper extremity revascularization when hostile conditions preclude other anatomic tunneling routes or extra-anatomic options.

Background Thoracic Outlet Syndrome (TOS) is a common condition caused by compression of neurovascular vessels traveling through the thoracic outlet. There are three categories of TOS, arterial (aTOS), neurogenic (nTOS), and venous (vTOS). These commonly present with pain in the neck, upper extremity weakness, paresthesia, swelling, and discoloration. TOS can be caused by a cervical rib, which is a rare and usually benign anomaly. This typically results in aTOS. Case This case, however, presents a 13-year-old male patient with nTOS caused by a cervical rib. He presented with weakness and pain of his right arm and a prior history of a partial neck mass resection. A physical exam revealed a firm supraclavicular mass and X-ray images confirmed the diagnosis of nTOS. Surgical resection of the anomalous rib was performed via a supraclavicular approach. Due to the difficulty of this operation, a multidisciplinary surgery team was formed, ensuring a positive outcome for the patient. Conclusions To our knowledge only two case reports of nTOS caused by a cervical rib compression of the brachial plexus exist. One was iatrogenic and the other treated non-surgically. Due to this lack of knowledge as well as the debate on surgical versus non-surgical treatment of TOS, this case report seeks to bolster the current literature with a positive outcome to correction of a rare presentation.

Thoracic outlet syndrome (TOS) refers to the collection of signs and symptoms associated with neurovascular compression in the thoracic outlet. The syndrome can be divided into three subtypes based on the source of compression. Neurogenic TOS results from compression of the brachial plexus, venous TOS results from compression of the subclavian vein, and arterial TOS results from compression of the subclavian artery. Compression of the nerve, vein, or artery can occur alone, but any combination can occur concurrently.

Venous thoracic outlet syndrome represents a relatively rare but important diagnosis in the adolescent population with increasing recognition. Compression of the subclavian vein within the costoclavicular space can lead to episodic venous outlet obstruction in the upper extremity, with edema, rubor and functional symptoms. Over time, cumulative injury and compression can lead to thrombosis of the vein, referred to as “effort thrombosis” or the Paget-Schroetter syndrome. This progression can lead to the need for acute management of the venous thromboembolism, requirement for thoracic outlet decompression surgery and the potential for long-term sequelae such as post-thrombotic syndrome. Management is focused on clot minimization, anticoagulation during the period of endothelial injury and inflammation and surgical decompression via first rib resection, anterior scalenectomy and venolysis to remove external compression of the vein. This manuscript reviews the diagnosis, evaluation and treatment of venous thoracic outlet syndrome and Paget-Schroetter syndrome.

In thoracic outlet syndrome (TOS) the narrowing between bony and muscular structures in the region of the thoracic outlet/inlet results in compression of the neurovascular bundle to the upper extremity. Venous compression, resulting in TOS (vTOS) is much more common than a stenosis of the subclavian artery (aTOS) with or without an aneurysm. Traditional open surgical approaches to remove the first rib usually lack good exposure of the entire rib and the neurovascular bundle. Between January 2015 and July 2021, 24 consecutive first rib resections for venous or arterial TOS were performed in 23 patients at our institutions. For our completely portal approach we used two 8mm working ports and one 12/8 mm camera port. Preoperatively, pressurized catheter-based thrombolysis (AngioJet®) was successfully performed in 13 patients with vTOS. Operative time ranged from 71–270 min (median 128.5 min, SD +/− 43.2 min) with no related complications. The chest tube was removed on Day 1 in all patients and the hospital stay after surgery ranged from 1 to 7 days (median 2 days, SD +/− 2.1 days). Stent grafting was performed 5–35 days (mean 14.8 days, SD +/− 11.1) postoperatively in 6 patients. The robotic approach to first rib resection described here allows perfect exposure of the entire rib as well as the neurovascular bundle and is one of the least invasive surgical approaches to date. It helps improve patient outcomes by reducing perioperative morbidity and is a procedure that can be easily adopted by trained robotic thoracic surgeons. In particular, patients with a/vTOS may benefit from careful and meticulous preparation and removal of scar tissue around the vessels.

Angiosarcoma is a rare soft tissue highly malignant tumor of vascular origin, accounting for only 1% to 2% of these tumors. We present a rare case of De novo (unrelated to irradiation or pyothorax) angiosarcoma of the thoracic outlet with a 10-year disease free survival. ? 49-year-old male was admitted to our department due to a tumor of the thoracic outlet referred by the neurologists to whom he addressed complaining for vertigo and instability. After a thorough examination including chest X-ray, CT scan and MRI, a well circumscribed vascularized lesion of a diameter of 5cm was detected in the thoracic outlet. A head and neck angiography was performed along with a full staging in order to exclude metastatic disease. The patient was submitted to high axillary thoracotomy. The adjacent structures were dissected, small arterioles arising from the subclavian artery, neo-vessels were ligated or cauterized and the soft largely encapsulated tumor was excised. Gross observation of the resected specimen demonstrated a regular-shaped neoplasm. Histology revealed a well differentiated angiosarcoma comprised of multiple anastomosing blood vessels lined by endothelial cells showing malignant features but with little nuclear pleomorphism. The recovery was uneventful. The patient did not receive postoperative radiation or chemotherapy and 10 years postoperatively is free of disease. In conclusion, de novo primary pleural angiosarcoma are rare entities that should not be misdiagnosed. The immunohistochemical examination is the key for diagnosis and will offer the definite histotype. Although the prognosis is bad, early detection will give the patient the best chance for successful surgical treatment. Our patient being well and asymptomatic after 10 years follow-up represents a rare case and the first mentioned in the literature with a location of the lesion in the thoracic outlet.

Introduction Thoracic outlet syndrome (TOS) refers to a spectrum of syndromes related to the compression of the brachial plexus (neurogenic TOS), subclavian vein or artery in the general region of the thoracic outlet, which is the area just above the first rib and behind the clavicle. Case report We report a 27-year-old healthy man who presented to the emergency department with right upper limb pain, tingling and weakness. Point-of-care ultrasonography was performed following a dynamic protocol in the supraclavicular fossa in the right upper limb. A congenital cervical rib, as well as narrowing of the costoclavicular gap, causing vein, artery and spinal roots compression was evidenced. This maneuver reproduced the symptoms, confirming the suspicion of neurogenic TOS. Discussion Early diagnosis is important, because the neurogenic compression associated with neurogenic TOS, if prolonged, can lead to muscle weakness and atrophy, being irreversible. Selected patients with neurogenic TOS who have progressive weakness, disabling pain, or who have failed to improve with conservative measures are considered for first rib resection. Conclusion Using the dynamic approach during point-of-care ultrasonography examination, in combination with physical examination and cervical radiography, could help identify neurogenic TOS.

Context: Stroke due to retrograde embolization in a case of arterial thoracic outlet syndrome (aTOS) is rare, and little is known about predisposing factors. Objective: The aim of this study is to analyze the predisposing factors and mechanisms of stroke in aTOS based on literature survey and experience with two cases. Materials and Methods: – Data Sources and Selection: Databases MEDLINE, PubMed, Scopus, and Cochrane Library were searched, supplemented by scanning of reference lists of relevant publications. All publications with subclavian artery/axillary artery stenosis/occlusion, either due to bony and/or muscular abnormality, in the thoracic outlet, with stroke, till January 2020 were included. Data Extraction: The clinical and anatomical details such as gender, age, side affected the type of stroke (anterior/posterior), bony/skeleton abnormality, upper limb symptoms, and their duration, were noted and analyzed. Data Synthesis: A systematic analysis of the accessed reports was performed. Statistical Analysis: The measure of the significance of the association of various factors was calculated with z-test. Results: Forty-eight articles describing 58 patients were identified. Fifty-five patients were analyzed. The involvement of the right upper limb (P = 0.00001), age

Introduction In venous thoracic outlet syndrome (VTOS), pathology around the axillosubclavian vein causes venous compression with the subsequent development of upper extremity symptoms. This case report describes the analysis of all possible compression sites and subsequent treatment of VTOS patients with multiple compression points. Report A 22 year old male presented with severe pain and swelling in his right arm, which persisted after a conservatively managed primary upper extremity deep vein thrombosis. Compression of the axillosubclavian vein was seen both at the level of the pectoralis minor and the costoclavicular spaces. Both compression points were successfully treated by combining thoracic outlet decompression surgery with pectoralis minor tenotomy. Discussion This report underlines the importance of considering the possibility of multiple compression sites in patients with VTOS. Incomplete surgical release of all compression points leaves patients prone to re-thrombosis and/or persistent post-thrombotic syndrome. Timely recognition of all abnormalities on venography may allow for adjustment of surgical treatment accordingly., Highlights • This case report presents a double compression of the axillosubclavian vein. • Venography allows for a dynamic assessment of all possible compression points. • This case underlines the importance of considering multiple compression sites. • Recognition of abnormalities allows adjustment by thoracic outlet decompression.

1. Stanley Lee, MD* 2. Ahmed Aly, MBBS* 3. Paayal Bhakta, MD* 4. Karthikeyan Parameswaran, MBBS* 5. Valeriy Chorny, MD* 6. Rohit Pinto, MD* 7. Jianying Zeng, MD† 8. Richard Hong, MD‡ 9. Melvyn Braiman, MD* 1. *Department of Pediatrics, 2. †Department of Pathology, and 3. ‡Department of Radiology, SUNY Downstate Medical Center and Kings County Hospital Center, Brooklyn, NY A 14-year-old boy is transferred from an outside hospital with a 1-day history of severe left upper neck swelling and pain without any known precipitating factors. Three years ago the patient had a similar episode: a painful left neck mass was diagnosed as lymphadenitis and treated with amoxicillin without sequelae. In the emergency department, vital signs and a complete blood count are within normal limits. The mass is soft and tender to palpation, measuring 1.0 × 1.5 cm. A computed tomographic (CT) scan with contrast reveals an expansile lesion stemming from the left aspect of the hyoid bone compressing the trachea (Fig 1). The ENT team performs a bedside laryngoscopy and confirms a rightward tracheal deviation and compression. Figure 1. Expansile lesion of the hyoid bone causing a rightward tracheal deviation. A computed tomographic scan of the neck revealing a 1.3-cm lesion from the left hyoid bone (blue arrow) with an associated 11.2-cm soft tissue mass expanding through the thoracic outlet. The lesion led to a rightward tracheal deviation and compression (red arrow). On admission to the inpatient unit, the patient is alert, oriented, and in mild distress due to pain, but his vital signs remain within normal limits. The neck mass remains very tender to palpation and has expanded to 4.0 × 5.0 cm on physical examination, a few hours after the initial measurement. His neck has limited movement, and there are no signs of respiratory distress, stridor, drooling, or retractions. He is able to speak in full sentences. He has some difficulty in swallowing solids but is tolerating liquids. He is started on …

Objective: Arterial compression at the thoracic outlet is rarely diagnosed before embolization occurs. Decompression, embolectomy, and resection of the subclavian artery and interposition graft repair is the most common method of treatment. This is a retrospective analysis of a single surgeon experience with subclavian artery repair without resection for arterial thoracic outlet syndrome. Materials and Methods: Sixty limbs underwent surgery for arterial compression at the thoracic outlet in 57 patients over the last 29 years (1989–2018). There were 24 males and 33 females. The age group varied from 10 to 60 years. Thrombointimectomy and repair of the subclavian artery were done on 54 of the 57 symptomatic limbs. Three patients underwent prophylactic decompression of the thoracic outlet on the contralateral asymptomatic side. Results: Fifty-two patients had complete cervical rib, two had abnormal first rib, and three patients had fracture clavicle with nonunion. Fifteen patients presented with severe rest pain and pregangrenous changes in the finger tips. All the rest presented with ischemic changes of varying degrees in the upper limb. The duration of symptoms ranged from 2 to 300 days. All patients underwent decompression of the thoracic outlet in the form of scalenectomy and cervical rib or first rib resection. Thrombointimectomy and repair of the poststenotic dilatation without resorting to resection were done in 54 limbs. Only three patients required resection of the artery. One patient had end-to-end anastomosis and two others had interposition grafts. In addition, 43 patients had additional transbrachial embolectomy to clear the distal artery. Two patients had cervicodorsal sympathectomy. No patient underwent major amputation, but two patients required finger amputation. Palpable wrist pulse could be achieved in 45 patients. Patients were followed for an average of 2 years. Palpable pulse disappeared at 6-month follow-up in four patients. These four and another three patients with palpable pulse and the remaining 12 patients with no wrist pulse continued to have minor ischemic symptoms in the fingertips. Long-term follow-up did not reveal any aneurysm or stenosis at the subclavian repair site. Conclusion: Cervical rib though a congenital condition can remain asymptomatic till a later age. Arterial compression is rarely diagnosed before embolisation occurs. The distal artery may not be completely cleared of thrombi, and about 30% of the patients continue to suffer from ischemic symptoms even after successful surgery. Hence, all patients with complete cervical rib should be investigated and followed up with duplex scan for evidence of arterial compression. They should be advised prophylactic decompression when they develop duplex evidence of arterial compression. Intimectomy and subclavian artery repair produce good long-term results, and unnecessary resection of the subclavian artery should be avoided.

Purpose To report results of percutaneous costoclavicular bypass for symptomatic thoracic outlet or cephalic arch occlusion in patients with arteriovenous fistula. Materials and Methods A retrospective review of percutaneous costoclavicular bypass patients between 2014 and 2018 was performed. Stent grafts were placed subcutaneously over the clavicle from the fistula outflow (axillary or cephalic vein) into a jugular vein or collateral. The procedures were performed in patients who had exhausted or were not candidates for balloon dilation or intravascular stent placement. Results Technical success was 100% (9/9) with resolution of symptoms in all patients. Indications were arm swelling in 67% (6/9), fistula dysfunction in 22% (2/7), and 1 enlarging aneurysm. The fistula outflow was cephalic in 67% (6/9) and axillary in 33% (3/9). The return vessel was external jugular in 78% (7/9) and internal jugular in 22% (2/9). Two overlapping Viabahn stent grafts were used in 88% of cases (7/8) and 3 stent grafts in 1 case. In the initial case, 2 Gore hybrid grafts were used. Stent graft diameter ranged from 9 mm to 13 mm. Mean follow-up was 852 ± 339 days (range, 488–1483 days). At 12 months and 24 months, primary patency was 67% and 67%, and secondary patency was 89% and 78%, respectively. Complications included late thrombosis and secondary infection. There were no anastomotic leaks or seromas associated with extravascular stent grafts. Conclusions The percutaneous costoclavicular bypass is a feasible option for thoracic outlet and cephalic arch occlusion in symptomatic dialysis patients.

Thoracic outlet syndrome (TOS) refers to a constellation of symptoms resulting from neurovascular compression at the thoracic outlet, causing some combination of pain in the neck and upper extremity, weakness, sensory loss, paresthesia, swelling, and discoloration. Classification of TOS would depend on the anatomical structure that is compressed: venous TOS (VTOS)—compression of Subclavian vein; arterial TOS (ATOS)—compression of subclavian artery; and neurogenic TOS (NTOS)—compression of brachial plexus. Postural Orthostatic Tachycardia Syndrome (POTS) is characterized by orthostatic tachycardia that develops in the absence of orthostatic hypotension, with a symptom duration of >6 months. POTS is now known to be commonly associated with Ehlers-Danlos Syndrome (EDS), thereby raising speculation about the extent of prevalence of TOS symptoms in EDS patients. The aim of the study was to quantify the influx of patients with POTS, reporting symptoms of arm fatigue with or without numbness and tingling. The symptoms were quantified initially by conducting postural maneuvers that would reproduce the symptoms, to rule-in the possibility of TOS and further confirmed by using ultrasonography in upper limbs as the imaging modality of choice to evaluate arterial and/or venous compression. This study also looks at the presence of a concurrent diagnosis of EDS among the symptomatic patients who test positive for TOS.

The case report presents a patient with a possible neuropathic sternal pain associated with a recent heart transplant procedure. The patient could not breathe deeply and move the upper limbs, with a trunk torsion, feeling a sharp pain under and around the left breastbone. A fascial osteopathic approach in the treatment of the pelvic floor, the respiratory diaphragm, the thoracic outlet, the tongue and the tentorium cerebelli allowed the patient to access to a cardiovascular rehabilitation program. In osteopathic medicine, these anatomical parts of the body are called the five diaphragms. To our best knowledge, this is the first case report that uses osteopathic treatment in a patient with sternal pain associated with an undergoing cardiac transplantation. The clinical importance of the case report is added to other osteopathic research with patients undergoing cardiac surgery (coronary artery bypass graft) and with multiple benefits, without side effects. One of the main goals of osteopathic treatment is to provide the patient with well-being, from many clinical points of view, allowing the person to be discharged from the hospital more quickly and/or with less pain.

CT angiogram (CTA) has become the modality of choice for imaging of thoracic vascular pathologies, involving the aorta and the pulmonary arteries. Apart from showing exquisite details of these large arteries, pathologies and anatomic variants of their branches can also be studied to a great extent. The major branches of aortic arch can be affected by a wide variety of pathologies ranging from atherosclerosis to trauma and vasculitis. Bronchial arteries in spite of supplying only 1% of lung parenchyma can become hypertrophied in various congenital and acquired conditions, becoming an important source of collateral circulation as well as a source for life threatening hemoptysis. CT also plays an important role in diagnosis of vascular compression at the thoracic outlet. With advances in CT technology, the acquisition, interpretation and clinical applications of CT angiography will continue to grow in the years to come.

Upper extremity deep vein thrombosis (UEDVT) may be the first manifestation of venous thoracic outlet syndrome (VTOS). It primarily affects young, physically active people. The clinical findings depend on the degree of obstruction of the subclavian vein. Correct diagnosis — aided by various imaging modalities — as well as rapid initiation of local thrombolytic therapy, surgical decompression of the thoracic outlet (when indications are present), and the immediate initiation of anticoagulation therapy aim at successfully restoring the patient’s quality of life.

Paget–Schroetter syndrome (PSS) is an upper extremity thrombosis occurring in the axillary and subclavian veins. PSS is also known as “effort thrombosis,” because it is usually associated with repetitive and strenuous activities of the upper limbs. We present 2 patients with atypical PSS, so-called “non-effort thrombosis,” who were not involved in vigorous activities. They underwent thoracic outlet decompression through the infraclavicular approach without concomitant venoplasty. They were discharged without postoperative anticoagulant therapy. Venography and computed tomography after surgery revealed successful recanalization of the subclavian vein in each case. We highlight the characteristic pathophysiology of “non-effort thrombosis,” an atypical PSS entity.

Thoracic outlet syndrome (TOS) consists of a group of distinct pathologies arising as a result of compression of structures at the thoracic outlet. The structures at risk are, from anterior to posterior, the subclavian vein, subclavian artery and brachial plexus. Compression or impingement causes venous (VTOS), arterial (ATOS) or neurogenic (NTOS) TOS. NTOS is the most common presentation, caused by compression of the brachial plexus at the scalene triangle or pectoralis minor space. Other compression syndromes at the carpal and cubital tunnels should be excluded. Management is usually conservative, employing physiotherapy and postural exercises, but pain or muscle wasting may be indications for surgery. VTOS is caused by compression of the subclavian vein at the costoclavicular junction, resulting in venous thrombosis, the Paget-Schroetter syndrome, often as a result of exercise in fit young muscular people or musicians. Positional swelling of the upper limb without thrombosis is termed McCleery's syndrome. In the presence of thrombosis, clot lysis, first rib excision and venoplasty may be indicated. ATOS occurs due to compression of the subclavian artery at the scalene triangle, often in association with an anomalous bony structure, such as cervical rib, causing post-stenotic aneurysmal dilation of the artery, thrombosis and embolization. Acute upper limb ischaemia necessitates urgent cervical rib excision and arterial reconstruction.

Objective Aberrant right subclavian artery (ARSA) is a rare anatomical variant of the origin of the right subclavian artery. ARSA is defined as the right subclavian artery originating as the final branch of the aortic arch. The purpose of this study is to determine the prevalence and the anatomy of ARSA evaluated with computed tomography (CT) angiography. Methods CT angiography was performed in 3460 patients between March 1, 2014 and November 30, 2015 and the results were analyzed. The origin of the ARSA, course of the vessel, possible inadvertent ARSA puncture site during subclavian vein catheterization, Kommerell diverticula, and associated vascular anomalies were evaluated. We used the literature to review the clinical importance of ARSA. Results Seventeen in 3460 patients had ARSA. All ARSAs in 17 patients originated from the posterior aspect of the aortic arch and traveled along a retroesophageal course to the right thoracic outlet. All 17 ARSAs were located in the anterior portion from first to fourth thoracic vertebral bodies and were located near the right subclavian vein at the medial third of the clavicle. Only one of 17 patients presented with dysphagia. Conclusion It is important to be aware ARSA before surgical approaches to upper thoracic vertebrae in order to avoid complications and effect proper treatment. In patients with a known ARSA, a right transradial approach for aortography or cerebral angiography should be changed to a left radial artery or transfemoral approach.

Sindrom gornjeg torakalnog otvora iznimno je složen kompresivni sindrom koji, još uvijek, zbunjuje velik broj zdravstvenih djelatnika diljem svijeta. Svake godine pojavljuje se značajan broj pacijenata sa širokim spektrom simptoma koji se automatski pripisuju drugim poremećajima i sindromima što dovodi do dugogodišnje patnje pacijenata u procesu posjećivanja različitih stručnjaka i pronalaska pravog uzroka. Pacijente se nerijetko uvjerava kako je njihovo stanje uzrokovano psihosomatskim razlozima te to uzrokuje daljnje frustracije i česti razvoj depresije i anksioznosti, posebice obzirom da prisutni simptomi uvelike ograničavaju svakodnevne aktivnosti. Razlog tome je slabo poznavanje sindroma gornjeg torakalnog otvora i njegovih mehanizama nastanka među zdravstvenim djelatnicima te manjak objektivnih kriterija u postavljanju točne dijagnoze. Detaljnim pretraživanjem literature pronađeno je svega nekoliko znanstvenih radova i članaka na hrvatskom jeziku. Cilj ovog diplomskog rada je prikazati detaljan opis sindroma gornjeg torakalnog otvora, njegovih mehanizama nastanka i raznih metoda rehabilitacije koje mogu potpomognuti u njegovom tretiranju, gdje najbitniju ulogu igra kineziterapija. Smatra se da je sindrom gornjeg torakalnog otvora sve češći problem današnjice obzirom na sve dominantniji sedentarni način života koji posljedično stvara krive posturalne mehanizme već u djetinjstvu. Zato je iznimno bitno pojačati svijest o pojavnosti ovoga sindroma i dovesti do sveobuhvatnih dijagnostičkih kriterija koji će doprinijeti jasnoj diferencijaciji sindroma gornjeg torakalnog otvora. Thoracic outlet syndrome is a very complex compression syndrome which, still, confuses a large number of healthcare professionals around the world. Every year a significant number of patients appear with a wide range of symptoms that are automatically attributed to other disorders and syndromes, which leads to long – term suffering of patients in the process of visiting various specialists and finding the real cause. Patients are often covinced that their condition is caused by psychosomatic reasons and this causes further frustrations and a frequent occurance of depression and anxiety, especially since the present symptoms greatly limit patients everyday activities. The reason for this is the poor understanding of the thoracic outlet syndrome and its occurence mechanisms among healthcare professionals and due to lack of objective criteria in providing an accurate diagnosis. A detailed search of the literature revealed only a few scientific papers and articles in the croatian language. The aim of this thesis is to present a detailed description of the thoracic outlet syndrome, its occurence mechanisms and various methods for rehabilitation which can help in its treatment, where the most important role is played by kinesitherapy. Thoracic outlet syndrome is thought to be an increasingly common problem today when taken into account the increasingly dominant sedentary lifestyle that consequently created bad postural mechanisms already in childhood. Therefore, it is extremely important to increase awereness of the occurrence of this syndrome and lead to comprehensive diagnostic criteria which will contribute to a clear differentiation of Thoracic outlet syndrome.

Materials and Methods Nineteen patients presented with an unsightly deformity of the shoulder, pain or discomfort at the medial scapular border, pseudo nonparalytic scapular winging, and thoracic outlet symptoms after excessive resection of the clavicle for either complete acromioclavicular separation or displaced fracture of the outer clavicle, which allows the scapula and shoulder to rotate anteriorly and inferiorly on the chest creating traction on the medial scapular muscles and the brachial plexus resulting in pseudo nonparalytic winging and thoracic outlet symptoms. Results All underwent transfer of the coracoid process with the attached conjoined tendon to the end of the clavicle, restoring length and alignment. Eighteen patients were evaluated at a mean of 13.3 years. Seventeen had resolution of symptoms, restored alignment of the clavicle with the shoulder, improved appearance, healed transfer, and were pleased with the outcome. One patient was lost to follow-up but was considered a failure at his last visit. In a second patient, the transfer healed in a tilted position and the patient was dissatisfied with the appearance but otherwise had resolution of his symptoms. The mean American Shoulder and Elbow Surgeons Outcome Score improved from 53.2 preoperatively to 87.4 postoperatively (P Conclusion This is the first report of using this transfer to restore length and alignment of an excessively short, unstable clavicle. The transfer succeeded in improving the appearance and symptoms in this complication of an excessively short, unstable clavicle.

Neurogenic thoracic outlet syndrome (NTOS) is an etiologically and clinically diverse disorder caused by compression of the brachial plexus traversing the thoracic outlet. Athletes who perform repetitive overhead activities are at risk of developing NTOS with sport-specific symptoms. This article reviews the controversial NTOS nomenclature, common sites of anatomic compression, and red flag symptoms that require immediate intervention. It also reviews the congenital, traumatic, and functional etiologies of NTOS, with a discussion of the differential diagnosis, diagnostic criteria, and workup for NTOS. Nonsurgical treatment is highlighted with an emphasis on thoracic outlet syndrome-specific physical therapy and updates on injection options and ultrasound guided hydrodissection. This article compares nonsurgical versus surgical functional outcome data with an emphasis on athletes with NTOS. Functional assessment tools and performance metrics for athletes are reviewed, as well as return to sport considerations.

Introduction and importance Mediastinal cystic lesions, such as paratracheal air cyst (PTAC) and bronchogenic cyst (BC), are rare anomaly usually found incidentally in thoracic imaging. Special attention is needed in the case of thoracic surgery. Case presentation All three patients were male, 71, 73, and 76 years old. Preoperative CT showed each had a lobular cystic lesion at the right posterolateral side of trachea in the thoracic outlet 11, 14, and 19 mm in size, respectively, with air density and tracheal communication, leading to a diagnosis of PTACs. An oval cystic lesion, 7 mm in size, was found in one patient at the right lateral side of the upper esophagus with low density and without tracheal communication, leading to a diagnosis of paraesophageal BC. Intraoperative findings of the three PTACs demonstrated a soft bulge from the membranous portion of trachea that was left intact. The BC had an oval elastic structure, mimicking a metastatic lymph node, and was removed with the mediastinal lymph nodes. Histological examination showed ciliated columnar epithelium, confirming a diagnosis of BC. Clinical discussion PTACs are associated with increased intraluminal pressure due to chronic lung disease. BCs are congenital anomalies that originate from abnormal budding of the embryonic foregut. Conclusion PTACs and BCs need to be considered in preoperative image diagnosis in patients with esophageal cancer. PTACs should be left intact to avoid tracheal injury, while removal of isolated BCs is recommended as a diagnostic and therapeutic measure., Highlights • Paratracheal air cyst (PTAC) and bronchogenic cyst (BC) are rare anomaly. • Three PTACs and a BC were found in patients who received thoracoscopic esophagectomy for esophageal cancer. • PTACs were carefully left intact to avoid tracheal injury. • BC was removed for diagnostic and therapeutic measure. • PTACs and BCs need to be considered in preoperative image diagnosis in patients with esophageal cancer.

Neurogenic thoracic outlet syndrome (N-TOS) is a chronic compressive brachial plexopathy that involves the C8, T1 roots, and/or lower trunk. Medial antebrachial cutaneous (MABC) nerve conduction study (NCS) abnormality is reportedly one of the most sensitive findings among the features of N-TOS. The aim of the present study was to report clinical features, imaging findings, treatment, and prognoses of two N-TOS patients with no abnormalities in electrophysiological studies. Both patients presented with paresthesia of unilateral arm, and examination revealed no neurologic deficits. Electrophysiologic studies including MABC NCS were normal. Computed tomography (CT) angiography and brachial plexus magnetic resonance imaging (MRI) of the patients showed compression and displacement of the neurovascular bundle in the thoracic outlet by causative structures. Due to their sensory symptoms and CT angiography and brachial plexus MRI findings, after excluding other diseases, we diagnosed them with N-TOS. With the development of imaging techniques, more patients presenting with clinical features of lower trunk brachial plexopathy and anomalous structures compressing the neurovascular bundle on imaging studies can be diagnosed with N-TOS, even if electrophysiologic studies including MABC NCS do not show abnormalities.

Thoracic outlet syndrome (TOS) encompasses a group of disorders caused by compression of the neurovascular structures serving the upper extremity, resulting in three distinct conditions (neurogenic, venous, and arterial). Successful surgical treatment for all types of TOS depends on sound understanding of the relationships between the musculoskeletal and neurovascular structures in this region, as well as the variable anatomy and pathologic findings likely to be encountered. The principal risks of thoracic outlet decompression revolve around the potential for nerve or vascular injury in this area, as well as operative inadequacies that may lead to persistent or recurrent problems. In current practice, the frequency of complications associated with thoracic outlet decompression are very low in the hands of experienced surgeons, but there remains potential for significant injury to the brachial plexus, phrenic nerve, long thoracic nerve, subclavian artery, and subclavian vein. Other potential concerns include postoperative pneumothorax, pleural effusion, wound hematoma and hemothorax, and persistent lymph leak and chylothorax. The frequency of persistent or recurrent symptoms of brachial plexus compression is one of the most challenging aspects of surgical treatment for neurogenic TOS, and late complications of treatment for venous TOS may include residual subclavian vein obstruction despite adequate decompression.