7,731 results on '"sulfadiazine"'
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52. URGO MEDICAL ITALIA secures contract for Medical Consumables - Lot 33 - Sterile Non-Adherent Contact Dressing With Silver Or Sulfadiazine
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Sulfadiazine ,Contract agreement ,News, opinion and commentary - Abstract
Italy based URGO MEDICAL ITALIA has secured contract from Societa di Committenza Regione Piemonte S.p.A. - S.C.R. - Piemonte S.p.A. for Medical Consumables - Lot 33 - Sterile Non-Adherent Contact [...]
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- 2024
53. Synthesis and Characterization of Sulfonamide-Containing Naphthalimides as Fluorescent Probes
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Zhi-Wei Liu, Fan Liu, Chun-Tao Shao, Guo-Ping Yan, and Jiang-Yu Wu
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fluorescent imaging ,fluorescent probe ,naphthalimide ,sulfonamide ,sulfadiazine ,Organic chemistry ,QD241-441 - Abstract
A tumor-targeting fluorescent probe has attracted increasing interest in fluorescent imaging for the noninvasive detection of cancers in recent years. Sulfonamide-containing naphthalimide derivatives (SN-2NI, SD-NI) were synthesized by the incorporation of N-butyl-4-ethyldiamino-1,8-naphthalene imide (NI) into sulfonamide (SN) and sulfadiazine (SD) as the tumor-targeting groups, respectively. These derivatives were further characterized by mass spectrometry (MS), nuclear magnetic resonance spectroscopy (1H NMR), Fourier transform infrared spectroscopy (FT-IR), ultraviolet–visible spectroscopy (UV), and a fluorescence assay. In vitro properties, including cell cytotoxicity and the cell uptake of tumor cells, were also evaluated. Sulfonamide-containing naphthalimide derivatives possessed low cell cytotoxicity to B16F10 melanoma cells. Moreover, SN-2NI and SD-NI can be taken up highly by B16F10 cells and then achieve good green fluorescent images in B16F10 cells. Therefore, sulfonamide-containing naphthalimide derivatives can be considered to be the potential probes used to target fluorescent imaging in tumors.
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- 2024
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54. Ecological Response of Enzyme Activities in Watershed Sediments to the Reintroduction of Antibiotics
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Yue Lu, Yongshan Chen, Jinghua Xu, Ying Feng, and Jinping Jiang
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oxytetracycline ,sulfadiazine ,enzyme activity ,watershed ,Jinjiang river ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
The impact of antibiotic residue on sediment ecology at the watershed level is not yet fully understood. In this investigation, varying concentrations of oxytetracycline (OTC) and sulfadiazine (SD) were added to the overlying water of both the upper (0–10 cm) and bottom sediment (20–30 cm) layers at the watershed scale to evaluate the ecological impact on sediment habitats through the analysis of the activities of enzymes, namely urease (UA), alkaline phosphatase (APA), peroxidase (POA), and dehydrogenase (DHA). Results showed that the levels of UA and APA in the bottom sediment layers exceeded those in the top sediment layer upon reintroduction of antibiotics. Conversely, the fluctuations in DHA were notably reduced across various types of antibiotics and exposure concentrations in the bottom sediment layers. Within the top sediment layers, as the concentration of OTC exposure increased, there was a corresponding elevation in POA levels. However, the response of POA initially ascended and subsequently descended with rising SD exposure concentration, although it consistently exceeded the control levels. In contrast, the response of DHA displayed an inverse correlation with OTC exposure concentration but a direct correlation with SD exposure concentration. At the watershed scale, under antibiotic exposure, UA and DHA exhibited significantly higher levels upstream compared to downstream. Conversely, APA and POA appeared relatively stable across the watershed following the reintroduction of antibiotics. Moreover, DHA demonstrated a noticeable decreasing trend with increasing concentrations of OTC exposure. Environmental factors had a predominant influence, exceeding 40%, on enzyme activities during antibiotic reintroduction. Specifically, particle size significantly inhibited enzyme activity, while sediment nutrient conditions, including total carbon, nitrogen, and sulfur content, significantly enhanced enzyme activities. The study suggests that enzyme activities associated with antibiotic reintroduction in watershed sediments are established during stable stages in the bottom sediment layer or downstream sediment environment as part of sedimentary and transport processes. More research is required to explore the maintenance and evolution of antibiotic resistance profiles in the presence of long-term antibiotic residues.
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- 2024
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55. Recent Approaches to Combat Toxoplasma Gondii with Plant-Derived Alternatives
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Niveria, Karishma, Yadav, Monika, Dangi, Kapil, Singh, Priyanka, Verma, Anita K., Kanwar, Jagat Rakesh, Singh, Archana, editor, Rathi, Brijesh, editor, Verma, Anita K., editor, and Singh, Indrakant K., editor
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- 2023
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56. Prototype for rapid test devices to detect residues of sulfonamides in chicken carcasses from traditional breeders in Surabaya, Indonesia
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Mochamad Lazuardi, Eka Pramyrtha Hestianah, and Tjuk Imam Restiadi
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diazotation ,food safety ,residues ,sulfadiazine ,veterinary drugs ,Animal culture ,SF1-1100 ,Veterinary medicine ,SF600-1100 - Abstract
Background and Aim: Sulfadiazine, one of the sulfonamide group’s active compounds, is widely used for therapeutic production against several diseases. Veterinary drug residues can have a significant impact on human health conditions. This study aimed to develop a prototype of rapid test devices (RTDs) for detecting sulfadiazine residues on chicken carcasses based on the color indication. Materials and Methods: Seven samples of carcasses collected from traditional breeders in Surabaya-Indonesia were prepared and tested using RTDs. This sample represents the population considering that in the last report, the use of antibiotics was more than 40%, while the ability to monitor RTDs was estimated at 100. The standard color of purple by Hex code standard color or decimal code color was used to compare the positive samples. A light-emitting diode (LED) lamp was used to observe purple color. Analysis of sulfonamides resulting from RTDs was compared using a ultraviolet-visible spectrophotometer. Results: Sulfonamides contamination levels of 50% and 100% were detected at concentrations of 0.472 µg/mL and 0.642 µg/mL, respectively. Sulfonamides contamination that was
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- 2023
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57. Synthesis, antimicrobial evaluation, and docking studies of new series Pyrazolone, Pyrimidine, Thiazine, and Pyranone derivatives bearing a Sulfonamide moiety using ultrasound irradiation
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Jala Bahjat Ziwar
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Sulfadiazine ,Antimicrobial evaluation ,Molecular Docking ,Ultrasound Irradiation ,Chemistry ,QD1-999 - Abstract
This study presents a green chemistry approach to synthesizing new heterocyclic compounds with sulfadiazine moiety using ultrasound techniques. Diazotization of sulfadiazine (1) that results in the formation of diazonium salt (1a) followed by coupling of the latter with active methylene compounds leads to hydrazine derivative (2a-d). Heterocyclization of compounds (2a-d) with hydrazine and phenyl hydrazine gives to a series of pyrazole derivatives (3a-d) and (4a-d) under ultrasound irradiation. Subsequently, the pyrimidine derivatives (5a-d) and thiazine derivatives (6a-d) were synthesized upon treatment of hydrazone compounds (2a-d) with urea and thiourea under ultrasound irradiation. Additionally, pyran derivatives 8 and 10 were synthesized by combining reactions 2a and 2c with acetylacetone under ultrasonic irradiation at 60 °C. The chemical structures of the produced compounds were determined using 1H, 13C NMR, and FT-IR spectroscopic techniques. These compounds displayed moderate to good antimicrobial effects on human-pathogenic bacteria types, like Escherichia coli and Staphylococcus aureus, and on fungal types, such as C. albicans, which was determined through the broth microdilution technique. Molecular docking studies were then employed to demonstrate the active sites and the binding affinity of the products to the target proteins or receptors in S. aureus (PDB ID Code: 1HSK).
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- 2023
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58. Stability of sulfadiazine sugar-free oral suspensions for the treatment of congenital toxoplasmosis
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Micheline Silva Dias, Amanda Maccangnan Zamberlan, Rebeca Lino Lourenço, Emanuele Saul Saraiva, Julya Sarmento Neis, Luana Mota Ferreira, and Andréa Inês Horn Adams
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Pediatric formulation ,Sulfadiazine ,Suspension ,Congenital toxoplasmosis ,Extemporaneous suspensions ,Pharmacy and materia medica ,RS1-441 - Abstract
Abstract This study aimed to develop and evaluate the stability of sulfadiazine sugar-free extemporaneous oral suspensions, focusing on treating congenital toxoplasmosis. The excipients were carefully chosen to obtain safe products for the pediatric population. Sulfadiazine suspensions (100 mg/ mL) were prepared from the raw material or tablets, stored in amber glass bottles at 5±3ºC, and evaluated at 0, 14, and 30 days. An ultra-performance liquid chromatographic method was developed and validated to assay the drug. The particle size ranged from 29.3 to 50.6 µm, with some variation over the study; pH values around 7.0 and non-Newtonian behavior were observed without modification in the period. Formulations showed a fast dissolution rate (>80% in 15 minutes) without variation over the study. The drug assay was about 100% of the label claimed throughout the study, demonstrating the chemical stability and the preparations’ dose homogeneity. The microbiological investigation indicated that both preparations met the requirements for the microbial count and absence of pathogens. In conclusion, the developed formulations can be used for 30 days when stored under refrigeration. The oral suspensions produced are easy to prepare and contain safe components, providing an alternative for congenital toxoplasmosis treatment in children.
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- 2023
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59. Synthesis, Crystal Structure Analyses, and Antibacterial Evaluation of the Cobalt(II) Complex with Sulfadiazine-Pyrazole Prodrug.
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Altowyan, Mezna Saleh, Haukka, Matti, Ayoup, Mohammed Salah, Ismail, Magda M. F., El Menofy, Nagwan G., Soliman, Saied M., Barakat, Assem, Sharaf, Mona M., Abu-Youssef, Morsy A. M., and Yousri, Amal
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CRYSTAL structure , *MOLECULAR structure , *COUNTER-ions , *SCHIFF bases , *COBALT , *INTERMOLECULAR interactions , *ATOMS - Abstract
The complex [Co(L)(H2O)4](NO3)2 of (E)-4-(2-(3-methyl-5-oxo-1-(pyridin-2-yl)-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-N-(pyrimidin-2-yl)benzenesulfonamide (L) was synthesized via the self-assembly technique. Its molecular and supramolecular structures were analyzed using FTIR, elemental analyses, and single-crystal X-ray diffraction, as well as Hirshfeld calculations. This complex crystallized in the triclinic space group P 1 ¯ with Z = 2. The crystallographic asymmetric unit comprised one complex cation and two nitrate counter anions. This complex had distorted octahedral geometry around the Co(II) ion. Numerous intermolecular interactions affecting the molecular packing of this complex were conformed using Hirshfeld investigations. The most significant contacts for the cationic inner sphere [Co(L)(H2O)4]2+ were O···H (38.8%), H···H (27.8%), and N···H (9.9%). On the other hand, the main interactions for the counter NO3¯ ions were the O···H (79.6 and 77.8%), O···N (8.0%), and O···C (9.1%). A high propensity for making interactions for each atom pair in the contacts O...H, N...C, N...H, and C...C was revealed by enrichment ratio values greater than 1. The antibacterial efficacy of the complex and the free ligand were assessed. The free ligand had higher antibacterial activity (MIC = 62.5–125 µg/mL) than the [Co(L)(H2O)4](NO3)2 complex (MIC ≥ 250 µg/mL) versus all the studied bacteria. [ABSTRACT FROM AUTHOR]
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- 2023
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60. Sulfadiazine analogs: anti-Toxoplasma in vitro study of sulfonamide triazoles.
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Arafa, Fadwa M, Osman, Doaa Hassan, Tolba, Mona Mohamed, Rezki, Nadjet, Aouad, Mohamed R, Hagar, Mohamed, Osman, Mervat, and Said, Heba
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SULFADIAZINE , *SULFONAMIDES , *TRIAZOLES , *IN vitro studies , *AMINO group - Abstract
Toxoplasmosis is an infection that prevails all over the world and is caused by the obligate intracellular protozoan parasite Toxoplasma gondii (T. gondii). Promising novel compounds for the treatment of T. gondii are introduced in the current investigation. In order to test their in vitro potency against T. gondii tachyzoites, six 1,2,3-triazoles-based sulfonamide scaffolds with terminal NH2 or OH group were prepared and investigated as sulfadiazine equivalents. When compared to sulfadiazine, which served as a positive control, hybrid molecules showed much more anti-Toxoplasma activity. The results showed that the IC50 of the examined compounds 3(a–f) were recoded as 0.07492 μM, 0.07455 μM, 0.0392 μM, 0.03124 μM, 0.0533 μM, and 0.01835 μM, respectively, while the sulfadiazine exhibited 0.1852 μM. The studied 1,2,3-triazole-sulfadrug molecular conjugates 3(a–f) revealed selectivity index of 10.4, 8.9, 25.4, 21, 8.3, and 29; respectively. The current study focused on the newly synthesized amino derivatives 3(d–f), as they contain the more potent amino groups which are recognized to be essential elements and promote better biological activity. Extracellular tachyzoites underwent striking morphological alterations after 2 h of treatment as seen by scanning electron microscopy (SEM). Additionally, the intracellular tachyzoite exposed to the newly synthesized amino derivatives 3(d–f) for a 24-h period of treatment revealed damaged and altered morphology by transmission electron microscopic (TEM) indicating cytopathic effects. Moreover, compound 3f underwent the most pronounced changes, indicating that it had the strongest activity against T. gondii. [ABSTRACT FROM AUTHOR]
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- 2023
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61. In vitro multitarget activity of sulfadiazine substituted triazenes as antimicrobial, cytotoxic, and larvicidal agents.
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Aydin, Hasan, Akocak, Süleyman, Lolak, Nebih, Uslu, Uğur, Sait, Ahmet, Korkmaz, Serol, Parmaksiz, Ayşe, Ceylan, Onur, and Aksakal, Abdulbaki
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SULFADIAZINE ,TRIAZENES ,POISONS ,VACCINIA ,DRUG resistance ,COUMARINS - Abstract
Multidrug resistance (MDR) causes difficulties in the treatment of infections and cancer. Research and development studies have become increasingly important for the strategy of preventing MDR. There is a need for new multitarget drug research and advancement to reduce the development of drug resistance in drug‐drug interactions and reduce cost and toxic effects. This study aimed to determine the effects of multi‐target triazene compounds on antibacterial, antifungal, antiviral, cytotoxic, and larvicidal activities were investigated in vitro. A series of 12 novel of 1,3‐diaryltriazene‐substituted sulfadiazine (SDZ) derivatives were synthesized, and the obtained pure products characterized in detail by spectroscopic and analytic methods (FT‐IR, 1H‐NMR, 13C‐NMR, and melting points). The antibacterial and antifungal activities of these derivatives (AH1‐12) were determined by broth microdilution method. All derivatives have been evaluated in cell‐based assays for cytotoxic and antiviral activities against Modified Vaccinia Virus Ankara. The larvicidal efficacy of these chemical compounds was also investigated by using Lucilia sericata (L. sericata) larvae. Twelve 1,3‐diaryltriazene‐substituted SDZ derivatives (AH1‐12) were designed and developed as potent multitargeted compounds. Among them, the AH1 derivative showed the most antibacterial and antifungal activity. Besides, synthesized derivatives AH2, AH3, AH5, and AH7 showed higher antiviral activity than SDZ. All synthesized derivatives showed higher cytotoxic activity than SDZ. Also, they showed larvicidal activity at 72 h of the experiment. As a result, these compounds might be great leads for the development of next‐generation multitargeted agents. [ABSTRACT FROM AUTHOR]
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- 2023
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62. Photodegradation performance and mechanism of sulfadiazine in Fe(III)-EDDS-activated persulfate system.
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Liang, Jianwei, Huang, Wenyu, Wei, Shiping, Tian, Chengyue, Zhang, Xinyun, Nong, Guoyou, Wang, Shuangfei, and Song, Hainong
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SULFADIAZINE ,SMALL molecules ,PHOTODEGRADATION ,RADICALS (Chemistry) ,PH effect ,HUMIC acid - Abstract
In order to overcome the shortcomings in the traditional Fenton process, Fe(III)-EDDS-activated persulfate advanced oxidation process under irradiation is carried out as a promising technology. The photodegradation of sulfadiazine (SD) in Fe(III)-EDDS-activated persulfate system was investigated in this paper. The results showed that SD could be effectively degraded in Fe(III)-EDDS/ S 2 O 8 2 − /hv system. The effects of Fe(III):EDDS molar ratio, the concentration of Fe(III)-EDDS, and the concentration of S 2 O 8 2 − on SD degradation were explored. At neutral pH, when Fe(III):EDDS = 1:1, Fe(III)-EDDS = 0.1 mM, S 2 O 8 2 − = 1.5 mM, the best SD degradation was achieved. The experiment of external influence factors showed that the degradation of SD could be obviously inhibited by the presence of C O 3 2 − , S O 4 2 − , whereas the degradation of SD was almost unaffected by the addition ofCl
− . The degradation of SD could be slightly inhibited by the presence of humic acid and NO3 − . The effect of pH on SD degradation was investigated, and SD could be degraded effectively in the pH range of 3–9. ESR proved that1 O2 , ·OH, S O 4 − , and O2 − were produced in the process. S O 4 − and ·OH were identified as the main radicals while O2 ·− also played non-ignorable role. Eleven intermediate products of SD were analysed. The C = N, S–N, and S–C bonds of SD were attacked by radicals firstly, leading to a series of reactions that eventually resulted in the destruction of SD molecules and the formation of small organic molecules. [ABSTRACT FROM AUTHOR]- Published
- 2023
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63. Visible light-driven photocatalysts, quantum chemical calculations, ADMET-SAR parameters, and DNA binding studies of nickel complex of sulfadiazine.
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Pandya, Sachin B., Socha, Bhavesh N., Dubey, Rahul P., Patel, Urmila H., Patel, R. H., Bhatt, Bhupesh S., Thakor, Parth, Bhakhar, Sanjay, Vekariya, Nikhil, and Valand, Jignesh
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SULFADIAZINE , *NICKEL , *MEASUREMENT of viscosity , *VISIBLE spectra , *PHOTOCATALYSTS , *ACETATES , *METHYLENE blue , *SCHIFF bases - Abstract
A 3D-supramolecular nickel integrated Ni-SDZ complex was synthesized using sodium salt of sulfadiazine as the ligand and nickel(II) acetate as the metal salt using a condensation process and slow evaporation approach to growing the single crystal. The metal complex was characterized for its composition, functional groups, surface morphology as well as complex 3D structure, by resorting to various analytical techniques. The interacting surface and stability as well as reactivity of the complex were carried out using the DFT platform. From ADMET parameters, human Intestinal Absorbance data revealed that the compound has the potential to be well absorbed, and also Ni-SDZ complex cannot cross the blood–brain barrier (BBB). Additionally, the complex's DNA binding affinity and in-vivo and in-vitro cytotoxic studies were explored utilizing UV–Vis absorbance titration, viscosity measurements, and S. pombe cells and brine shrimp lethality tests. In visible light radiation, the Ni-SDZ complex displayed exceptional photo-degradation characteristics of approximately 70.19% within 70 min against methylene blue (MB). [ABSTRACT FROM AUTHOR]
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- 2023
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64. Electrochemical Monitoring of Sulfadiazine via La@CeO Incorporated with Reduced Graphene Oxide.
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Disouza, Francis Packiaraj Don, Sundaresan, Ruspika, Chen, Shen-Ming, Ramachandran, Balaji, and Chandrasekar, Narendhar
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GRAPHENE oxide , *SULFADIAZINE , *NANOPARTICLES , *ENVIRONMENTAL sampling , *WATER sampling - Abstract
In recent years, indiscriminate consumption and dumping of antibiotics have become destructive to human health and causes ecotoxicological pollution. Here, the irregular particle nanosized dendrite structure of lanthanum-doped cerium oxide (LCO) decorated with sheet-like reduced graphene oxide (RGO) composite was utilized to detect the sulfonamide-based drug sulfadiazine (SZ). LCO@RGO nanocomposite was prepared using the hydrothermal method, the synergistic effect between LCO and RGO facilitates electron transferability and conductivity which enhances the electrochemical properties toward the detection of SZ. The detection of SZ expressed a lower detection limit (0.005 µM) and linear range (0.01–265 µM) of the fabricated LCO@RGO/GCE electrode toward SZ, analyzed using the highly sensitive DPV technique. Also, DPV was utilized to determined shows good repeatability, reproducibility, and storage stability of fabricated LCO@RGO/GCE. Moreover, effective practicability was proven in human blood serum and river water samples with great recovery results. All the above probes the synthesized LCO@RGO's thriving and outstanding electrocatalytic performance of this nanocomposite's highly sensitive detection of SZ in real biological and environmental samples. [ABSTRACT FROM AUTHOR]
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- 2023
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65. NEW METHOD OF SULFADIAZINE RESIDUE BIODEGRADATION IN POULTRY MANURE BY SPORE-BOUNDING LACCASE.
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CHAIJAK, Pimprapa
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POULTRY manure , *LACCASE , *SULFADIAZINE , *ANTIBIOTIC residues , *BIODEGRADATION , *LIVESTOCK farms , *POULTRY farming - Abstract
Antibiotics have been used in livestock farming worldwide. In poultry farming, sulfonamide antibiotics are mainly used to inhibit microbial infection. Sulfadiazine (SDZ) is one type of sulfonamide that is secreted into the ecosystem through feces and urine owing to its low adsorption and degradation in the animal intestine. In this study, the spore-bound laccase from the Bacillus sp. strains was investigated for its potential for degradation of SDZ. The highest laccase activity was selected to degrade the SDZ residue in the poultry feces. The results demonstrated that the spore-bound laccase of Bacillus sp. PM45 successfully reduced the residue of SDZ in poultry manure by 98.00±0.50 %. This work gained new knowledge and the method is cost-effective and more eco-friendly for antibiotic residue treatment. [ABSTRACT FROM AUTHOR]
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- 2023
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66. Simultaneous degradation of sulfadiazine and dissolved organic matter based on low‐impact development facilities.
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Yuan, Donghai, Xiong, Siyu, Yan, Chenling, Zhai, Linxiao, Cui, Yanqi, and Kou, Yingying
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DISSOLVED organic matter , *SULFADIAZINE , *ORGANIC bases , *ORGANIC compounds , *SOIL infiltration , *SOIL percolation , *ANTIBIOTICS - Abstract
Sulfadiazine (SD) is a common antibiotic administered to treat bacterial infections in livestock, and its fate and migration are greatly affected by dissolved organic matter (DOM). The soil infiltration system [a typical low-impact development (LID) facility] can significantly alter DOM properties during runoff pollution, thus affecting the complexation of SD with DOM. Here, the binding characteristics of different DOM components and SD in the soil infiltration system were explored using spectroscopic techniques (excitation–emission matrices, parallel factor analysis, and synchronous fluorescence spectroscopy). Combined with the weakening of DOM fluorescence intensity and 78.63% reduction in mean SD concentration following treatment, synchronous degradation may have occurred. The binding sequence of SD and DOM fluorophores was further explored using two-dimensional correlation spectroscopy. Effluent DOM showed greater sensitivity to SD and more binding sites than influent DOM. Moreover, hydrophobic protein-like substances exhibited higher log K M values than other fluorescent components, indicating that protein-like components play significant roles in SD complexation. The soil percolation system improved the complexation stability and binding sequence of fulvic-like substances. Thus, SD–DOM can be intercepted and degraded using LID facilities to reduce the risk of SD in aquatic environments. [ABSTRACT FROM AUTHOR]
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- 2023
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67. Bioaccumulation and Depletion of the Antibiotic Sulfadiazine 14 C in Lambari (Astyanax bimaculatus).
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Evangelista, Patrícia Alexandre, Lourenço, Felipe Machado de Oliveira, Chakma, Darmin, Shaha, Chironjit Kumar, Konate, Almamy, Pimpinato, Rodrigo Floriano, Louvandini, Helder, and Tornisielo, Valdemar Luiz
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DRUG disposal , *FISH feeds , *SULFADIAZINE , *ASTYANAX , *BIOACCUMULATION in fishes , *BIOACCUMULATION , *SEWAGE disposal plants - Abstract
Simple Summary: Antibiotics are present in the environment and can be bioaccumulated by organisms and transferred through the food chain, which poses a problem when considering fish meat consumption. The study focused on lambari, a fish with potential in aquaculture because of its ease of rearing in small-scale operations. The objective of the study was to measure the bioaccumulation and clearance of the antibiotic sulfadiazine (SDZ) in lambaris. The tests were divided into two phases: exposure and depletion. During exposure, the fish were fed medicated feed for seven days, and during depletion they were transferred to clean tanks and fed uncontaminated feed for another seven days. SDZ concentrations increased in the fish over the days, with the greatest accumulation occurring on day seven. After the depletion phase, SDZ concentrations decreased. The results showed that there was little bioaccumulation of SDZ in the fish, but that the compound was more present in the water. The results also indicated that the concentrations of SDZ were below the established maximum limit. This study contributes to the understanding of the dynamics of SDZ in an aquatic species native to Brazil. Antibiotics are present in the environment, primarily due to their release through wastewater treatment plants, agricultural practices, and improper disposal of unused medications. In the environment, these drugs can be bioaccumulated by organisms and transferred along the food chain. This is a problem when considering the consumption of fish meat. In the United States, legislation stipulates that the maximum residue limit for sulfadiazine (SDZ) should not exceed 100 μg kg−1. Lambari fishes have potential economic importance in aquaculture, as they are relatively easy to breed and can be raised in small-scale operations. Finally, studying the biology and ecology of lambari could provide valuable information about freshwater ecosystems and their inhabitants. The current work aimed to measure the bioaccumulation and depletion of the antibiotic SDZ 14C in lambari (Astyanax bimaculatus). For this purpose, the tests were divided into two stages; seven days of exposure and seven days of depletion, where one fish was randomly selected and sampled every day. In the exposure phase, the fish were fed the medicated feed three times a day at a concentration of 2.5 mg·g−1. The control fish were fed uncontaminated feed. For the depletion phase, the remaining lambari were transferred to clean tanks and fed uncontaminated feed three times a day. The fish samples were burned in the Oxidizer and the reading of radioactivity was performed in a liquid scintillation spectrometer. It is worth noting that on day 7 and day 14, the water in the aquariums was filtered through filter paper to collect the metabolic excrement. SDZ concentrations increased over the days and accumulation occurred in the fish, with day seven presenting the maximum accumulation value of 91.7 ng·g−1 due to feeding uptake. After the depletion phase on day 13, the value found was 0.83 ng·g−1. The bioconcentration factor calculated was 20 L·kg−1. After the bioaccumulation period, the concentrations of SDZ in the water and excreta were 4.5 µg·L−1 and 363.5 ng·g−1, respectively. In the depletion period, the concentrations in the water and excreta were 0.01 µg·L−1 and 5.96 ng·g−1, respectively. These results imply that there was little SDZ bioaccumulation in the fish, but that it was distributed in larger amounts in the water. This is due to the physicochemical properties of the molecule with the low Log P value. Regarding the maximum residue limit, the value was below the established value. This study contributes to understanding SDZ dynamics in an aquatic species native to Brazil. [ABSTRACT FROM AUTHOR]
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- 2023
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68. Experimental and DFT study on the removal of sulfadiazine by activated carbon prepared from Rubus alceifolius
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Umdor, R. S., Ezung, S. L., Sharma, S., Kumar, S., Longchar, I. T., and Sinha, D.
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- 2024
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69. Effects of Hydrothermal Pretreatment and Anaerobic Digestion of Pig Manure on the Antibiotic Removal and Methane Production
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Guo, Chunchun, Ma, Yanfang, Li, Yitao, Wang, Zhiwu, Lin, Shupeng, Dong, Renjie, and Liu, Shan
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- 2024
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70. World Trade Organization: Committee on Sanitary and Phytosanitary Measures - Notification - Japan - Veterinary drug - Residues - Sulfadiazine
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International economic relations ,Sulfadiazine ,Business, international ,World Trade Organization - Abstract
Geneva, Switzerland: World Trade Organization has issued the following document: The Complete document can be viewed at this link: [...]
- Published
- 2024
71. P05-41 Simulations of antibiotics in dairy cattle in PKSim: a case study of sulfadiazine and trimethoprim.
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Lautz, L., Fischer-Holzhausen, S., and Siccardi, M.
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DAIRY cattle , *SULFADIAZINE , *TRIMETHOPRIM , *ANTIBIOTICS - Published
- 2024
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72. Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis
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- 2021
73. Synergistic effects of layered Ti3C2TX MXene/MIL-101(Cr) heterostructure as a sonocatalyst for efficient degradation of sulfadiazine and acetaminophen in water
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Kugalur Shanmugam Ranjith, Seyed Majid Ghoreishian, Soobin Han, Nilesh R. Chodankar, Ganji Seeta Rama Raju, Supriya J. Marje, Yun Suk Huh, and Young-Kyu Han
- Subjects
Ti3C2Tx MXene ,Sonocatalytic degradation, MIL-101(Cr) ,Sulfadiazine ,Acetaminophen ,Pharmaceutical pollutants ,Chemistry ,QD1-999 ,Acoustics. Sound ,QC221-246 - Abstract
In this work, different mass loadings of MXene-coupled MIL-101(Cr) (MXe/MIL-101(Cr)) nanocomposites were generated through a hydrothermal process in order to investigate the potential of this nanocomposite as a novel sonocatalyst for the elimination of sulfadiazine (SD) and acetaminophen (AAP) in aqueous media. The sonocatalytic activity of different MXe/MIL-101(Cr) compositions and surface functionalities was investigated. In addition, the sonocatalytic activities at various pH values, temperatures, pollutant concentrations, catalyst dosages, initial H2O2 concentrations, and organic matter contents were investigated. The experiments on the sonocatalytic elimination of SD and AAP revealed that MXe/MIL-101(Cr) exhibited a catalytic efficiency of ∼ 98% in 80 min when the MXene loading was 30 wt% in the nanocomposite. Under optimized reaction conditions, the degradation efficiency of MXe/MIL-101(Cr) reached 91.5% for SD and 90.6% for AAP in 60 min; these values were 1.2 and 1.8 times greater than those of MXene and MIL-101(Cr), respectively. The high surface area of the MXe/MIL-101(Cr) nanocomposite increased from 4.68 m2/g to 294.21 m2/g, and the band gap of the tagged MIL-101(Cr) on the MXene surface was minimized. The superior sonocatalytic activity of MXe/MIL-101(Cr) was attributed to the effective contact interface, the effective separation rate of e- − h+ pairs through the type II heterostructure interface, and the favorable high free •OH radical production rates that promoted the degradation of SD and AAP. The solid heterointerface between MIL-101(Cr) and MXene was confirmed through Raman and FTIR analysis and was found to promote accessible •OH radical production under sonication, thus maximizing the catalytic activity of nanocomposites. The present results present an effective strategy for the design of a highly efficient, low-cost, reliable sonocatalyst that can eradicate pharmaceutical pollutants in our environment.
- Published
- 2023
- Full Text
- View/download PDF
74. FITERMAN DISTRIBUTION secures contract for Various Medicinal Products -Silver Sulfadiazine Cream 10Mg/G 50G
- Subjects
Silver sulfadiazine ,Precious metals industry -- Contracts ,Sulfadiazine ,Contract agreement ,News, opinion and commentary - Abstract
Romania based FITERMAN DISTRIBUTION has secured contract from Institutul de Boli Infectioase Prof. Dr. Matei Bals for Various Medicinal Products -Silver Sulfadiazine Cream 10Mg/G 50G. The value of the contract [...]
- Published
- 2024
75. FILDAS TRADING secures contract for Various Medicinal Products - Combinations - Micronized Silver Sulfadiazine 0.1G+9.7G Light Kaolin/10G Powder
- Subjects
Powders ,Silver sulfadiazine ,Sulfadiazine ,Contract agreement ,News, opinion and commentary - Abstract
Romania based FILDAS TRADING has secured contract from Spital Clinic Judetean de Urgenta Arad for Various Medicinal Products - Combinations - Micronized Silver Sulfadiazine 0.1G+9.7G Light Kaolin/10G Powder. The value [...]
- Published
- 2024
76. FARMEXIM S.A. secures contract for Various Medicinal Products - Sulfadiazine 10 Mg/G + Hydrogenated Peanut Oil
- Subjects
Sulfadiazine ,Contract agreement ,News, opinion and commentary - Abstract
Romania based FARMEXIM S.A. has secured contract from Spital Clinic Judetean de Urgenta Arad for Various Medicinal Products - Sulfadiazine 10 Mg/G + Hydrogenated Peanut Oil. The value of the [...]
- Published
- 2024
77. FITERMAN DISTRIBUTION secures contract for Pharmaceutical Products - Silver Sulfadiazine 1%
- Subjects
Silver sulfadiazine ,Drug wholesalers ,Precious metals industry -- Contracts ,Sulfadiazine ,Contract agreement ,News, opinion and commentary - Abstract
Romania based FITERMAN DISTRIBUTION has secured contract from SPITALUL DE BOLI PSIHICE CRONICE BORSA for Pharmaceutical Products - Silver Sulfadiazine 1%. The value of the contract is worth 3380 RON. [...]
- Published
- 2024
78. MEDIPLUS EXIM secures contract for Various Medicinal Products - Silver Sulfadiazine Cream 10Mg/G 50G
- Subjects
Silver sulfadiazine ,Precious metals industry -- Contracts ,Sulfadiazine ,Contract agreement ,News, opinion and commentary - Abstract
Romania based MEDIPLUS EXIM has secured contract from Institutul de Boli Infectioase Prof. Dr. Matei Bals for Various Medicinal Products - Silver Sulfadiazine Cream 10Mg/G 50G. The value of the [...]
- Published
- 2024
79. PHARM AHEAD S.R.L. secures contract for Various Medicinal Products - Silver Sulfadiazine Cream 10Mg/G 50G
- Subjects
Silver sulfadiazine ,Precious metals industry -- Contracts ,Sulfadiazine ,Contract agreement ,News, opinion and commentary - Abstract
Romania based PHARM AHEAD S.R.L. has secured contract from Institutul de Boli Infectioase Prof. Dr. Matei Bals for Various Medicinal Products - Silver Sulfadiazine Cream 10Mg/G 50G. The value of [...]
- Published
- 2024
80. FITERMAN DISTRIBUTION secures contract for Various Medicinal Products - 1 Silver Sulfadiazine Cream 10Mg/G 50G
- Subjects
Silver sulfadiazine ,Precious metals industry -- Contracts ,Sulfadiazine ,Contract agreement ,News, opinion and commentary - Abstract
Romania based FITERMAN DISTRIBUTION has secured contract from Institutul de Boli Infectioase Prof. Dr. Matei Bals for Various Medicinal Products - 1 Silver Sulfadiazine Cream 10Mg/G 50G. The value of [...]
- Published
- 2024
81. GUATEMALAN INSTITUTE OF SOCIAL SECURITY -IGSS- invites tenders for Igss Code 1384 Argentine Sulfadiazine Cream Jar 400 G
- Subjects
Sulfadiazine ,News, opinion and commentary - Abstract
GUATEMALAN INSTITUTE OF SOCIAL SECURITY -IGSS-, Guatemala has invited tenders for Igss Code 1384 Argentine Sulfadiazine Cream Jar 400 G. Tender Notice No: 23353902 Deadline: June 17, 2024 Copyright © [...]
- Published
- 2024
82. SOCIAL INSURANCE FUND invites tenders for Multilumen Central Venous Catheter Tray Coated with Chlorhexidine and Silver Sulfadiazine, Iida Call, 1000969549-08-31, See Technical Specifications
- Subjects
Silver sulfadiazine ,Insurance ,Chlorhexidine ,Sulfadiazine ,Insurance industry ,News, opinion and commentary - Abstract
SOCIAL INSURANCE FUND, Panama has invited tenders for Multilumen Central Venous Catheter Tray Coated with Chlorhexidine and Silver Sulfadiazine, Iida Call, 1000969549-08-31, See Technical Specifications. Tender Notice No: 2024-1-10-0-08-LP-533663 Deadline: [...]
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- 2024
83. SOCIAL INSURANCE FUND invites tenders for Silver Sulfadiazine 1% Cream /Pot 100-400G Vtsee Attached Specifications and Conditions
- Subjects
Silver sulfadiazine ,Insurance ,Sulfadiazine ,Insurance industry ,News, opinion and commentary - Abstract
SOCIAL INSURANCE FUND, Panama has invited tenders for Silver Sulfadiazine 1% Cream /Pot 100-400G Vtsee Attached Specifications and Conditions. Tender Notice No: 2024-1-10-0-08-LP-532367 Deadline: May 16, 2024 Copyright © 2011-2022 [...]
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- 2024
84. HEALTH AFFAIRS AT THE MINISTRY OF NATIONAL GUARD invites tenders for Aa-Silver Sulfadiazine 1% Cream Jar-Pr 2171581
- Subjects
Silver sulfadiazine ,Military personnel ,Sulfadiazine ,News, opinion and commentary - Abstract
HEALTH AFFAIRS AT THE MINISTRY OF NATIONAL GUARD, Saudi Arabia has invited tenders for Aa-Silver Sulfadiazine 1% Cream Jar-Pr 2171581. Tender Notice No: 2171581 Deadline: May 16, 2024 Copyright © [...]
- Published
- 2024
85. GUATEMALAN INSTITUTE OF SOCIAL SECURITY -IGSS- invites tenders for Argentine Sulfadiazine Crema Tarro 400 G
- Subjects
Sulfadiazine ,News, opinion and commentary - Abstract
GUATEMALAN INSTITUTE OF SOCIAL SECURITY -IGSS-, Guatemala has invited tenders for Argentine Sulfadiazine Crema Tarro 400 G. Tender Notice No: 22996877 Deadline: May 14, 2024 Copyright © 2011-2022 pivotalsources.com. All [...]
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- 2024
86. Efficient purification of aqueous solutions contaminated with sulfadiazine by coupling electro-Fenton/ultrasound process: optimization, DFT calculation, and innovative study of human health risk assessment.
- Author
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Nasab, Ehsan Abbasi, Nasseh, Negin, Damavandi, Sobhan, Amarzadeh, Mohamadamin, Ghahrchi, Mina, Hoseinkhani, Atefeh, Alver, Alper, khan, Nadeem A., Farhadi, Asadollah, and Danaee, Iman
- Subjects
HEALTH risk assessment ,SULFADIAZINE ,AQUEOUS solutions ,DENSITY functional theory ,HUMAN experimentation ,WATER sampling - Abstract
In the current work, the hybrid process potential of ultrasound (US) and electro-Fenton (EF), named sono-electro-Fenton (SEF), was fully investigated for sulfadiazine (SDZ) degradation. The decontamination in the integration approach was revealed to be greater than in individual procedures, i.e., EF process (roughly 66%) and US process (roughly 15%). The key operating process factors (i.e., applied voltage, H
2 O2 content, pH, initial concentration of SDZ, and reaction time) affecting SDZ removal were evaluated and optimized using Box-Behnken Design (BBD). In addition, an adaptive neuro-fuzzy inference system (ANFIS) as an efficient predictive model was applied to forecast the decontamination efficiency of SDZ through the SEF process based on the same findings produced from BBD. The results revealed that the predictability of SDZ elimination by the ANFIS and BBD approaches exhibited an excellent agreement (a greater R2 of 0.99%) among the both models. Density functional theory was also employed to forecast the plausible decomposition elucidation by the bond-breaking mechanism of organic substances. Plus, the main side products of SDZ degradation during the SEF process were tracked. Eventually, the non-carcinogenic risk assessment of different samples of natural water containing SDZ that was treated by adopting US, EF, and SEF processes was examined for the first time. The findings indicated that the non-carcinogenic risk (HQ) values of all the purified water sources were computed in the permissible range. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
87. The Effect of Dietary Synbiotics in Actively Racing Standardbred Horses Receiving Trimethoprim/Sulfadiazine.
- Author
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Lagounova, Maria, MacNicol, Jennifer L., Weese, J. Scott, and Pearson, Wendy
- Subjects
- *
SYNBIOTICS , *HORSE racing , *SULFADIAZINE , *TRIMETHOPRIM , *MICROBIAL communities , *RACE horses , *HORSES - Abstract
Simple Summary: Synbiotics are often provided to horses receiving antibiotics to protect against disturbances of gut microbioma, despite a lack of evidence for efficacy. The purpose of this study was to evaluate the effect of a synbiotic (PROBIOPlusTM) in horses receiving antibiotics. Sixteen actively racing Standardbred horses were randomly allocated to one of four groups: antibiotics (10 days; AB), synbiotic (28 days; PBP), PBP + AB, or Control. Make-up of the bacterial gut population was assessed, as well as indicators of manure quality. The PBP + AB group had a significantly different population of bacteria in their manure compared with all other groups. Most of the differences were found in bacterial populations that function to degrade fiber, including Fibrobacter and Ruminococcaceae. The Fibrobacter population was significantly higher in AB and PBP + AB horses than Control. For Ruminococcaceae, Control was significantly higher than AB and PBP during antibiotic treatment, and PBP + AB horses were significantly higher than PBP horses after antibiotic treatment. In conclusion, these data provide support for the ability of PROBIOPlus™ to maintain healthy gastrointestinal microbiome during antibiotic treatment. Synbiotics are often provided to horses receiving antibiotics to protect against microbiome disturbances, despite a lack of evidence for efficacy. The purpose of this study was to evaluate the effect of a synbiotic product in horses receiving antibiotics. Sixteen actively racing Standardbred horses were randomly allocated (four-way crossover) to one of four groups: antibiotics (10 days; AB), synbiotics (28 days; PROBIOPlusTM; PBP), PBP + AB, or Control. The fecal microbiome was investigated using 16S rRNA sequencing, and fecal dry matter (DM; %), pH, and scores (FS; 0–9) were measured. Data were analyzed with two-way ANOVA. Results found microbiota differences in community membership between PBP + AB and all other treatments during and after antibiotic treatment. During antibiotic treatment, AB and PBP + AB were significantly different from Control. After antibiotic treatment, PBP + AB was significantly different from all other treatments. The few differences found in relative abundance of phyla or predominant genera were mostly in fiber degrading bacteria. The Fibrobacter population was significantly higher in AB and PBP + AB horses than Control. Unclassified Ruminococcaceae was significantly higher in Control than AB and PBP. After antibiotic treatment, PBP + AB horses were significantly higher than PBP horses. In conclusion, these data provide support for the ability of PROBIOPlus™ to maintain healthy gastrointestinal microbiome during antibiotic treatment. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
- View/download PDF
88. Combining Polymer and Cyclodextrin Strategy for Drug Release of Sulfadiazine from Electrospun Fibers.
- Author
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Morais, Diego C., Fontes, Marina L., Oliveira, Analú B., Gabbai-Armelin, Paulo R., Ferrisse, Túlio M., De Oliveira, Luiz F. C., Brighenti, Fernanda Lourenção, Barud, Hernane S., and De Sousa, Frederico B.
- Subjects
- *
SUPRAMOLECULAR polymers , *CYCLODEXTRINS , *SULFADIAZINE , *TRANSDERMAL medication , *FIBERS , *DRUG delivery systems - Abstract
This study reports the fabrication of polymeric matrices through electrospinning using polymethyl methacrylate (PMMA) and poly(lactic-co-glycolic acid) (PLGA), biocompatible polymers commonly used in medical systems. These polymers were combined with an antibacterial drug, sulfadiazine sodium salt (SDS) or its supramolecular system formed with hydroxypropyl-β-cyclodextrin (HPβ/CD) at 1:1 molar ratio, aiming to assemble a transdermal drug delivery system. The formation of fibers was confirmed by scanning electron microscopy (SEM), and the fibers' surface properties were analyzed using contact angle and water vapor permeability techniques. Drug release tests and cell viability assays were performed to evaluate the potential toxicity of the material. SEM images demonstrated that the obtained fibers had nanoscale- and micrometer-scale diameters in PLGA and PMMA systems, respectively. The contact angle analyses indicated that, even in the presence of hydrophilic molecules (SDS and HPβCD), PMMA fibers exhibited hydrophobic characteristics, while PLGA fibers exhibited hydrophilic surface properties. These data were also confirmed by water vapor permeability analysis. The drug release profiles demonstrated a greater release of SDS in the PLGA system. Moreover, the presence of HPβCD improved the drug release in both polymeric systems and the cell viability in the PMMA SDS/HPβCD system. In terms of antibacterial activity, all membranes yielded positive outcomes; nevertheless, the PLGA SDS/HPβCD membrane exhibited the most remarkable results, with the lowest microbial load values. Additionally, the pseudo wound healing analysis demonstrated that the PLGA SDS/HPβCD fiber exhibited results similar to the control group. Consequently, these findings exemplify the substantial potential of the obtained materials for use in wound healing applications. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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- View/download PDF
89. Sulfadiazine Elimination from Wastewater Effluents under Ozone-Based Catalysis Processes.
- Author
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Li, Ruixue, Zhang, Yanqiong, Lu, Fengru, Li, Feng, Xu, Lijie, Gan, Lu, Cui, Chao, Li, Xuesong, Jin, Qiutong, Chu, Wei, Yan, Muting, and Gong, Han
- Subjects
- *
SULFADIAZINE , *CATALYSIS , *SEWAGE , *OZONE generators , *WASTEWATER treatment , *HYDROXYL group , *LAND degradation - Abstract
The presence of antibiotic sulfadiazine (SFD) poses threats to the ecosystem and human health, and traditional wastewater treatment processes are not ideal for sulfadiazine removal. Therefore, it is urgent to develop treatment processes with high efficiency targeting sulfadiazine. This study investigated the degradation and mineralization mechanisms of SFD by ozone-based catalysis processes including ozone/persulfate (PS) and ozone/peroxymonosulfate (PMS). The degradation, mineralization and byproducts of SFD were monitored by HPLC, TOC and LC/MS, respectively. SFD was efficiently removed by two ozone-based catalysis processes. Ozone/PMS showed high efficiency for SFD removal of 97.5% after treatment for 1 min and TOC reduction of 29.4% after treatment for 20 min from wastewater effluents. SFD degradation was affected by pH, oxidant dosage, SFD concentration and anions. In the two ozone-based catalysis processes, hydroxyl radicals (OH•) and sulfate radicals (SO4•−) contributed to the degradation of SFD. The degradation pathways of SFD under the two processes included hydroxylation, the opening of the pyrimidine ring and SO2 extrusion. The results of this study demonstrate that the two ozone-based catalysis processes have good potential for the elimination of antibiotics from water/wastewater effluents. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
90. Oral pharmacokinetics of sulfadiazine and sulfamonomethoxine in female Holstein milking cows.
- Author
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Tsuyoshi TAJIMA, Masumi SAIGA, Haru YAMAMOTO, ELBADAWY, Mohamed, ABUGOMAA, Amira, Ryotaro MIURA, Tatsuya USUI, Kazuaki SASAKI, and Minoru SHIMODA
- Subjects
ORAL drug administration ,SULFADIAZINE ,COWS ,PHARMACOKINETICS ,GOAT milk ,INTRAVENOUS therapy - Abstract
The efficacy of orally administered drugs in cattle is thought to be slow because of the anatomical and physiological features of their forestomach. Thus, parenteral routes are mainly preferred to administer drugs. However, the effect of some drugs with unique physicochemical properties was promptly obtained even after oral administration in clinically ill cattle. Therefore, the present study aimed to investigate pharmacokinetically the usefulness of the oral route in cattle by comparing the oral pharmacokinetic properties of two sulfonamides with different physicochemical properties. Sulfadiazine (SDZ) and sulfamonomethoxine (SMM) were administered by intravenous and oral route to four female Holstein cows with a 4-weeks washout period. Blood samples were collected over time, and SDZ and SMM concentrations in plasma were analyzed by HPLC. Data obtained from the same animal after intravenous and oral administration were simultaneously analyzed with the one compartment model, and kinetic parameters were calculated. The Tmax (mean ± SD) of SMM (2.75 ± 0.96 hr) was significantly achieved earlier than that of SDZ (5.00 ± 1.15 hr). Further, the mean absorption time of SMM (5.24 ± 0.69 hr) was significantly shorter than that of SDZ (5.92 ± 1.11 hr). Also, the half-life of absorption of SMM (3.91 ± 0.51 hr) was significantly shorter than that of SDZ (4.51 ± 0.82 hr). These data suggest that the absorption rates of highly unionized drugs (such as SMM) from the forestomach of cattle may be markedly higher than less unionized ones (such as SDZ). [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
91. Prototype for rapid test devices to detect residues of sulfonamides in chicken carcasses from traditional breeders in Surabaya, Indonesia.
- Author
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Lazuardi, Mochamad, Hestianah, Eka Pramyrtha, and Restiadi, Tjuk Imam
- Subjects
- *
SULFONAMIDES , *CHICKENS , *COLOR codes , *VETERINARY drug residues , *LIGHT emitting diodes - Abstract
Background and Aim: Sulfadiazine, one of the sulfonamide group's active compounds, is widely used for therapeutic production against several diseases. Veterinary drug residues can have a significant impact on human health conditions. This study aimed to develop a prototype of rapid test devices (RTDs) for detecting sulfadiazine residues on chicken carcasses based on the color indication. Materials and Methods: Seven samples of carcasses collected from traditional breeders in Surabaya-Indonesia were prepared and tested using RTDs. This sample represents the population considering that in the last report, the use of antibiotics was more than 40%, while the ability to monitor RTDs was estimated at 100. The standard color of purple by Hex code standard color or decimal code color was used to compare the positive samples. A light-emitting diode (LED) lamp was used to observe purple color. Analysis of sulfonamides resulting from RTDs was compared using a ultravioletvisible spectrophotometer. Results: Sulfonamides contamination levels of 50% and 100% were detected at concentrations of 0.472 µg/mL and 0.642 µg/mL, respectively. Sulfonamides contamination that was <0.395 µg/mL did not appear purple. Conclusion: The study's findings showed that RTDs can be used to detect sulfonamides residues at a limit of detection 0.5 µg/mL after a 45 min exposure to an LED operating at a wavelength of 980 nm (p < 0.05). The limitation of RTDs was not being able to monitor the presence of residues bound in fat samples. Rapid test devices can be developed for commonly monitoring devices due to the limited technology available in the market. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
92. Development and Validation of Aptasensor Based on MnO 2 for the Detection of Sulfadiazine Residues.
- Author
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Zheng, Xiaoling, Yang, Lulan, Sun, Qi, Zhang, Lei, and Le, Tao
- Subjects
SULFADIAZINE ,HIGH performance liquid chromatography ,ELECTROSTATIC interaction ,ENVIRONMENTAL sampling ,MOLECULAR dynamics - Abstract
The monitoring of sulfadiazine (SDZ) is of great significance for food safety, environmental protection, and human health. In this study, a fluorescent aptasensor based on MnO
2 and FAM-labeled SDZ aptamer (FAM-SDZ30-1) was developed for the sensitive and selective detection of SDZ in food and environmental samples. MnO2 nanosheets adsorbed rapidly to the aptamer through its electrostatic interaction with the base, providing the basis for an ultrasensitive SDZ detection. Molecular dynamics was used to explain the combination of SMZ1S and SMZ. This fluorescent aptasensor exhibited high sensitivity and selectivity with a limit of detection of 3.25 ng/mL and a linear range of 5–40 ng/mL. The recoveries ranged from 87.19% to 109.26% and the coefficients of variation ranged from 3.13% to 13.14%. In addition, the results of the aptasensor showed an excellent correlation with high-performance liquid chromatography (HPLC). Therefore, this aptasensor based on MnO2 is a potentially useful methodology for highly sensitive and selective detection of SDZ in foods and environments. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
93. Effects of sulfadiazine and Cu on soil potential nitrification and ammonia-oxidizing archaea and bacteria communities across different soils.
- Author
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Guoqin Hou, Zafran Gul Wazir, Jing Liu, Guizhen Wang, Fangxu Rong, Yuzhi Xu, Mingyue Li, Kai Liu, Aijv Liu, Hongliang Liu, and Fayuan Wang
- Subjects
COPPER ,AMMONIA-oxidizing bacteria ,SULFADIAZINE ,SOILS ,NITRIFICATION ,SOIL microbial ecology ,GRASSLAND soils ,PLANT-soil relationships - Abstract
Introduction: Sulfadiazine (SDZ) and copper (Cu) are frequently detected in agricultural soils, but little is known on their single or combined impact on ammonia oxidizing microbial community and function across different soils. Methods: In this study, a microcosm was conducted to distinguish the microbial ecotoxicity of SDZ and Cu across different soils by analyzing soil potential nitrification rate (PNR) and the amoA gene sequences. Results: The results showed that the single spiking of SDZ caused a consistent decrease of soil PNR among three tested soils, but no consistent synergistic inhibition of SDZ and Cu was observed across these soils. Moreover, across three tested soils, the distinct responses to the single or joint exposure of SDZ and Cu were found in amoA gene abundance, and diversity as well as the identified genus taxa of ammonia-oxidizing archaea (AOA) and bacteria (AOB). Meanwhile, only the specific genus taxa of AOA or AOB consistently corresponded to the variation of soil PNR across different treated soils. The further principal component analysis (PCA) exhibited that the variable influence of SDZ and Cu on ammonia oxidizing microbial community and function was greatly dependent on soil type. Discussion: Therefore, in addition to ecological functionality and the specific prokaryotic taxa, soil microbial ecotoxicity of SDZ and Cu also was dependent on edaphic factors derived from soil types. This study proposes an integrative assessment of soil properties and multiple microbial targets to soil contamination management. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
94. Biological Inspired Green Synthesis of TiO2 Coupled g-C3N4 Nanocomposites and Its Improved Activities for Sulfadiazine and Bisphenol A Degradation.
- Author
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Khan, Iltaf, Khan, Shoaib, Chen, Jinyin, Shah, Sayyar Ali, and Yuan, Aihua
- Subjects
- *
SULFADIAZINE , *GINGER , *BISPHENOL A , *NANOCOMPOSITE materials , *ENVIRONMENTAL degradation , *POLLUTANTS - Abstract
In this research study an eco-friendly approach is utilized to synthesize the green g-C3N4 based nanocomposites by employing Zingiber officinale as stabilizer and mediator. Our results proved that the green g-C3N4 have good performances and exceptional visible light photocatalytic activities as compared to the chemically synthesized g-C3N4. The small surface area, and low charge separation of g-C3N4 is upgraded by coupling with TiO2 nanoparticles. Our experimental results have confirmed that Zingiber officinale worked as stabilizer and mediator, while the coupling of TiO2 worked as facilitator and photoelectron modulator to enhance the charge separation. Compared to pristine green g-C3N4 (GCN), the most active sample 5Ti/GCN showed ~ 2.5-fold improvement in photocatalytic activities for sulfadiazine and bisphenol A degradation. The degradation pathways of sulfadiazine and bisphenol A showed the mineralization steps and production of less hazardous and small molecules (CO2 and H2O). Finally, our current novel research work will provide a new gateway to synthesize the plant assisted and eco-friendly green nanomaterials and its employment for pollutants degradation and environmental purification. Graphical abstract representing the Zingiber officinale mediated synthesis of TiO2 coupled g-C3N4 green nanocomposites [ABSTRACT FROM AUTHOR]
- Published
- 2023
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95. Perioperative anaphylactic reactions to central venous and pulmonary artery catheters containing chlorhexidine, sulfadiazine, or latex: a historical cohort study.
- Author
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Pinnock, Terrique M., Volcheck, Gerald W., Smith, Mark M., Murray, Andrew W., Renew, Johnathan R., and Smith, Bradford B.
- Abstract
Copyright of Canadian Journal of Anaesthesia / Journal Canadien d'Anesthésie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
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- View/download PDF
96. A Novel Rare Earth and Covalent Organic Framework Composite for Rapid and Highly Sensitive Electrochemical Analysis of Sulfadiazine in Fish Muscle.
- Author
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Han, Jiajia, Liao, Zicong, Chen, Guosheng, Qiu, Junlang, and Zhu, Fang
- Subjects
ELECTROCHEMICAL analysis ,CHARGE transfer kinetics ,ELECTROCHEMICAL sensors ,RARE earth metals ,SULFADIAZINE ,HUMAN ecology - Abstract
The misuse of sulfadiazine (SFZ) has led to great hazard to the environment and human safety; therefore, a simple, rapid, and sensitive method to detect sulfadiazine is urgently needed. Herein, we report a simple fabrication method for rare earth vanadate samarium (SmV)-doped covalent organic framework COF
TDBA-TTL nanocomposites (SmV/COFTDBA-TTL ), which were used to construct a sulfadiazine (SFZ) electrochemical sensor. The synergistic effect arising from the combination of SmV and COFTDBA-TTL accelerates the charge transfer kinetics, along with the creation of more surface-active sites that benefit effective detection. Compared with other electrochemical sensors, this electrochemical sensor exhibits low detection limit (2.40 nM), wide linear range (7.32–12.0 μM), good reproducibility (RSD = 0.823%), and stability (RSD = 3.60%). It provides a novel method and theoretical basis for the application of rare earth COF-based electrochemical sensors to detect environmentally destructive pollutants. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
97. Drug release and antimicrobial property of Cellulose Nanofibril/β-Cyclodextrin/Sulfadiazine films.
- Author
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Michel, Bastien, Heggset, Ellinor B., Sillard, Cécile, Syverud, Kristin, Dufresne, Alain, and Bras, Julien
- Subjects
CELLULOSE ,ANTI-infective agents ,PHYSISORPTION ,ANTIBACTERIAL agents ,CARBOXYLIC acids ,SULFADIAZINE - Abstract
Active Principal Ingredient (API) encapsulation through adsorption and physical entrapment onto TEMPO-oxidized cellulose nanofibrils (toCNFs) is possible, but challenges such as burst release and use of low water-soluble API such as sulfadiazine (SD) are yet to be addressed. The objective of this study is to assess the release property and antibacterial activity of toCNF/β-Cyclodextrin (β-CD)/SD materials in the form of films. Release in sink conditions was achieved with result highlighting the importance of the toCNF network structure, which is tightened at acidic pH for toCNFs due to its carboxylic content, reducing the burst effect phenomena. Antibacterial activity against Staphylococcus aureus and Escherichia coli was assessed and the results showed a clear beneficial impact of using β-CDs. An antibacterial effect for toCNF/SD films is confirmed for 3 successive applications whereas an antibacterial effect for a toCNF/CMβCD/SD film is prolonged up to 7 successive applications. The improvement of the topical release of a prophylactic agent with these materials are making them promising for biomedical applications such as wound dressing. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
98. Adsorptive removal of pharmaceutically active compounds from multicomponent system using Azadirachta indica induced zinc oxide nanoparticles: analysis of competitive and cooperative adsorption
- Author
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Nayanathara O. Sanjeev, Manjunath Singanodi Vallabha, and Aswathy E Valsan
- Subjects
acetaminophen ,adsorption ,competitive adsorption ,green synthesis ,sulfadiazine ,zinc oxide nanoparticle ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
In this research, zinc oxide (ZnO) nanoparticles synthesized using neem leaf (Azadirachta indica) extract were used as an adsorbent for removing two widely used pharmaceutical compounds acetaminophen (AMP) and sulfadiazine (SDZ). The synthesized ZnO nanoparticles were characterized using SEM-EDS, FTIR, TEM, BET, and XRD analysis. The synthesized ZnO nanoparticles were found to be in the size range of 10 nm with a surface area of 48.551 m2/g. The adsorptive performance of ZnO nanoparticles in both mono-component (MoS) and multi-component system (MuS) was investigated under various operational parameters viz. contact time, temperature, pH, concentration of pharmaceutical compound and ZnO nanoparticles dose. It was observed that the maximum adsorption capacity of ZnO nanoparticles was 7.87 mg/g and 7.77 mg/g for AMP and SDZ, respectively, under the optimum conditions of 7 pH and 2 g/L adsorbent dosage. The experimental data best-fitted with the pseudo-second-order model and Langmuir model, indicating monolayer chemisorption. Further investigation on removal of AMP and SDZ from multicomponent system was modelled using a Langmuir competitive model. The desorption study has shown 25.28% and 22.4% removal of AMP and SDZ from the surface of ZnO nanoparticles. In general, green synthesized ZnO nanoparticles can be utilized effectively as adsorbent for removal of pharmaceutically active compounds from wastewater. HIGHLIGHTS Zinc oxide nanoparticles were synthesized from Azadirachta indica leaf extract.; Removal of pharmaceutically active compounds sulfadiazine and acetaminophen using ZnO nanoparticles was investigated in a mono-component and multi-component system.; An adsorption study in a multi-component system was performed using Langmuir's competitive model and nature of adsorption was studied.; Recyclability of the adsorbent was studied.;
- Published
- 2023
- Full Text
- View/download PDF
99. Comparative Analysis of Cost-effectiveness of Silver Dressing in Burns (ARGENTUM)
- Author
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Luciane Cruz Lopes, Professor - Researcher
- Published
- 2021
100. Thermodynamic Analysis of the Solubility of Sulfadiazine in (Acetonitrile 1-Propanol) Cosolvent Mixtures from 278.15 K to 318.15 K
- Author
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Carlos Francisco Trujillo-Trujillo, Fredy Angarita-Reina, Mauricio Herrera, Claudia Patria Ortiz, Rossember Edén Cardenas-Torres, Fleming Martinez, and Daniel Ricardo Delgado
- Subjects
sulfadiazine ,solubility ,cosolvent ,thermodynamics ,acetonitrile ,1-propanol ,Organic chemistry ,QD241-441 - Abstract
Drug solubility is one of the most significant physicochemical properties as it is related to drug design, formulation, quantification, recrystallization, and other processes, so understanding it is crucial for the pharmaceutical industry. In this context, this research presents the thermodynamic analysis of the solubility of sulfadiazine (SD) in cosolvent mixtures {acetonitrile + 1-propanol} at 9 temperatures (278.15 K–318.15 K), which is a widely used drug in veterinary therapy, and two solvents of high relevance in the pharmaceutical industry, respectively. The solubility of SD, in cosolvent mixtures {acetonitrile + 1-propanol} is an endothermic process where the maximum solubility was reached in pure acetonitrile at 318.15 K and the minimum in 1-propanol at 278.15 K. Although the solubility parameters of acetonitrile and propanol were similar, the addition of acetonitrile to the cosolvent mixture leads to a positive cosolvent effect on the solubility of DS. As for the thermodynamic functions of the solution, the process is strongly influenced by enthalpy, and according to the enthalpy–entropy compensation analysis, the process is enthalpy-driven in intermediate to rich mixtures in 1-propanol and entropy-driven in mixtures rich in acetonitrile.
- Published
- 2022
- Full Text
- View/download PDF
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