264 results on '"natural agents"'
Search Results
52. Strategic and Innovative Roles of lncRNAs Regulated by Naturally-derived Small Molecules in Cancer Therapy.
- Author
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Alkan AH, Ensoy M, and Cansaran-Duman D
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- Humans, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Antineoplastic Agents chemistry, Small Molecule Libraries chemistry, Small Molecule Libraries pharmacology, Small Molecule Libraries therapeutic use, Biological Products pharmacology, Biological Products chemistry, Biological Products therapeutic use, Animals, RNA, Long Noncoding genetics, RNA, Long Noncoding metabolism, Neoplasms drug therapy, Neoplasms genetics
- Abstract
In the field of precision and personalized medicine, the next generation sequencing method has begun to take an active place as genome-wide screening applications in the diagnosis and treatment of diseases. Studies based on the determination of the therapeutic efficacy of personalized drug use in cancer treatment in the size of the transcriptome and its extension, lncRNA, have been increasing rapidly in recent years. Targeting and/or regulating noncoding RNAs (ncRNAs) consisting of long noncoding RNAs (lncRNAs) are promising strategies for cancer treatment. Within the scope of rapidly increasing studies in recent years, it has been shown that many natural agents obtained from biological organisms can potentially alter the expression of many lncRNAs associated with oncogenic functions. Natural agents include effective small molecules that provide anti-cancer effects and have been used as chemotherapy drugs or in combination with standard anti-cancer drugs used in routine treatment. In this review, it was aimed to provide detailed information about the potential of natural agents to regulate and/or target non-coding RNAs and their mechanisms of action to provide an approach for cancer therapy. The discovery of novel anti-cancer targets and subsequent development of effective drugs or combination strategies that are still needed for most cancers will be promising for cancer treatment., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
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- 2024
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53. Wound Healing: A Brief Look at the Inflammatory Stage and Role of Medicinal Plants and Their Derivations on Modulating the Inflammatory Responses: A Systematic Review.
- Author
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Raei Abbasabadi O and Farahpour MR
- Abstract
Aims: Wound is believed to be a major disorder in certain organs and/or tissues, which could be transmitted to other tissues. Skin is constantly exposed to infections, injuries, scratches, and burns. Wound dressings are commonly utilized for the treatment of wound site and protect it from external contamination. The biological importance of natural agents, such as herbal medicines and their derivations including extracts, essential oils and active compounds in the wound healing process has attracted the attention of researchers and also some manufacturers of wound dressings. Such natural agents improve wound healing by their antioxidant and antibacterial properties. This novel review article was conducted to evaluate the effects of medicinal plants and their derivations on inflammatory responses in surgical wound infection. Methods: The data were collected from various databases using specific keywords. Results: The results revealed that different medicinal plants and their derivations decrease the inflammation in the wound healing process by modulating in gene expression of inflammatory cytokines and immune cells. Conclusion: Active compounds of medicinal plants can alleviate inflammation in the wound healing process, which must be taken into consideration in pharmaceutical industries., Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2023
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54. Enhanced Activity and Sustained Release of Protocatechuic Acid, a Natural Antibacterial Agent, from Hybrid Nanoformulations with Zinc Oxide Nanoparticles
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Khaled AbouAitah, Urszula Piotrowska, Jacek Wojnarowicz, Anna Swiderska-Sroda, Ahmed H. H. El-Desoky, and Witold Lojkowski
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ZnO nanoparticles ,protocatechuic acid prodrug ,natural agents ,hybrid nanoformulation ,delivery system ,sustained release ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Hybrid nanostructures can be developed with inorganic nanoparticles (NPs) such as zinc oxide (ZnO) and natural antibacterials. ZnO NPs can also exert antibacterial effects, and we used them here to examine their dual action in combination with a natural antibacterial agent, protocatechuic acid (PCA). To produce hybrid nanoformulations, we functionalized ZnO NPs with four types of silane organic molecules and successfully linked them to PCA. Physicochemical assessment confirmed PCA content up to ~18% in hybrid nanoformulations, with a PCA entrapment efficiency of ~72%, indicating successful connection. We then investigated the in vitro release kinetics and antibacterial effects of the hybrid against Staphylococcus aureus. PCA release from hybrid nanoformulations varied with silane surface modification. Within 98 h, only 8% of the total encapsulated PCA was released, suggesting sustained long-term release. We used nanoformulation solutions collected at days 3, 5, and 7 by disc diffusion or log reduction to evaluate their antibacterial effect against S. aureus. The hybrid nanoformulation showed efficient antibacterial and bactericidal effects that also depended on the surface modification and at a lower minimum inhibition concentration compared with the separate components. A hybrid nanoformulation of the PCA prodrug and ZnO NPs offers effective sustained-release inhibition of S. aureus growth.
- Published
- 2021
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55. Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management
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Chandra K. Singh, Gagan Chhabra, Arth Patel, Hao Chang, and Nihal Ahmad
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prostate malignancy ,zinc transporters ,metallothioneins ,natural agents ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Studies have suggested an important role of the trace element zinc (Zn) in prostate biology and functions. Zn has been shown to exist in very high concentrations in the healthy prostate and is important for several prostatic functions. In prostate cancer (PCa), Zn levels are significantly decreased and inversely correlated with disease progression. Ideally, restoration of adequate Zn levels in premalignant/malignant prostate cells could abort prostate malignancy. However, studies have shown that Zn supplementation is not an efficient way to significantly increase Zn concentrations in PCa. Based on a limited number of investigations, the reason for the lower levels of Zn in PCa is believed to be the dysregulation of Zn transporters (especially ZIP and ZnT family of proteins), metallothioneins (for storing and releasing Zn), and their regulators (e.g., Zn finger transcription factor RREB1). Interestingly, the level of Zn in cells has been shown to be modulated by naturally occurring dietary phytochemicals. In this review, we discussed the effect of selected phytochemicals (quercetin, resveratrol, epigallocatechin-3-gallate and curcumin) on Zn functioning and proposes that Zn in combination with specific dietary phytochemicals may lead to enhanced Zn bioaccumulation in the prostate, and therefore, may inhibit PCa.
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- 2021
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56. Multiple pharmacological approaches on hydroalcoholic extracts from different parts of Cynoglossum creticum Mill. (Boraginaceae).
- Author
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Menghini, Luigi, Ferrante, Claudio, Zengin, Gokhan, Mahomoodally, Mohamad Fawzi, Leporini, Lidia, Locatelli, Marcello, Cacciagrano, Francesco, Recinella, Lucia, Chiavaroli, Annalisa, Leone, Sheila, Brunetti, Luigi, and Orlando, Giustino
- Subjects
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PHENOL oxidase , *BORAGINACEAE , *EXTRACTS , *HYDROGEN peroxide , *PHENOLS , *CELL lines - Abstract
Cynoglossum creticum Mill (Boraginaceae) is used traditionally as a remedy to manage several human ailments. In this context, the present study aimed to perform multiple pharmacological investigations on the hydroalcoholic extracts prepared from Cynoglossum roots and aerial parts (leaves and flowers). We evaluated the antioxidant and enzyme inhibitory (against cholinesterases, α-glucosidase, α-amylase, lipase and tyrosinase) activity of the extracts. The protective effect(s) of the extracts on cardiomyocyte C2C12 and intestinal HCT116 cell lines challenged with hydrogen peroxide (H2O2) was studied. We found that the aerial parts harbored the highest amount of phenolic compounds. Generally, aerial parts showed significant antioxidant and enzyme inhibitory effects. Leaves exhibited the best lipase inhibitory activity (173.15 mgOE/g extract), followed by flowers and roots. The root and aerial extracts were equally able to blunt intracellular H2O2 induced reactive oxygen species production from both C2C12 and HCT116 cell lines. Both cells lines could be treated with scalar concentrations of root and flower extracts in the range 50–300 μg/mL without interferences on cell viability. In conclusion, the present study showed protective effects exerted by Cynoglossum extracts, which could serve as a foundation for the development of pharmaceuticals and nutraceuticals derived from Cynoglossum. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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57. New pharmacological targets of three Asphodeline species using in vitro and ex vivo models of inflammation and oxidative stress.
- Author
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Zengin, Gokhan, Locatelli, Marcello, Ferrante, Claudio, Menghini, Luigi, Orlando, Giustino, Brunetti, Luigi, Recinella, Lucia, Chiavaroli, Annalisa, Leone, Sheila, Leporini, Lidia, Aumeeruddy, Muhammad Zakariyyah, and Mahomoodally, Mohamad Fawzi
- Subjects
- *
PHYTOTHERAPY , *ANIMAL experimentation , *COLON (Anatomy) , *GENE expression , *INFLAMMATION , *INTERLEUKINS , *LACTATE dehydrogenase , *MICE , *NITRATES , *PROSTAGLANDINS , *TUMOR necrosis factors , *PLANT extracts , *OXIDATIVE stress , *IN vitro studies , *IN vivo studies - Abstract
This study explored the efficacy of the methanolic extract of three Asphodeline species (A. damascena subsp. rugosa, A. tenuior subsp. tenuiflora var. tenuiflora, and A. cilicica) to protect against hydrogen peroxide (H2O2)-induced lactate dehydrogenase (LDH) activity in HCT116 cells, and also any protective effects against lipopolysaccharides (LPS)-induced nitrite levels, prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2α (8-iso-PGF2α) levels, 5HIAA/5-HT ratio, tumor necrosis factor (TNF)-α and interleukin (IL)-6 gene expression in rat colon specimens. Interestingly, A. tenuior extract was most effective in improving the tested biomarkers, by reducing LDH activity and nitrite level. On the other hand, A. damascena was the only species able to blunt LPS-induced TNF-α gene expression in rat colon specimens. The present findings highlighted the protective effects of Asphodeline extracts via in vitro and ex vivo models of inflammation and oxidative stress, adding new insights to the pharmacological actions of these medicinal plant species. Abbreviations: IBD: inflammatory bowel disease; LPS: lipopolysaccharide; LDH: lactate dehydrogenase; 5HIAA: 5-hydroxyindoleacetic acid; 5-HT: 5-hydroxytryptamine [ABSTRACT FROM AUTHOR]
- Published
- 2019
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58. Effect of commercial herbal toothpastes and mouth rinses on the prevention of enamel demineralization using a microcosm biofilm model.
- Author
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Braga, Aline Silva, Girotti, Letícia Dragonetti, de Melo Simas, Leticia Lobo, Pires, Juliana Gonçalves, Pelá, Vinícius Taioqui, Buzalaf, Marília Afonso Rabelo, and Magalhães, Ana Carolina
- Subjects
TOOTHPASTE ,TOOTH demineralization ,DENTAL enamel ,MOUTH ,PROPOLIS ,PREVENTION - Abstract
This work evaluated the effects of commercial toothpastes and mouth rinses containing natural/herbal agents on biofilm viability, extracellular polysaccharide (EPS) production and on enamel demineralization in vitro. Microcosm biofilm was produced on bovine enamel for 5 days and treated daily with: Orgânico natural
® (toothpaste/mouth rinse), Boni Natural Menta & Malaleuca® (toothpaste/mouth rinse), Propolis & Myrrh® (toothpaste), Colgate Total 12 Clean Mint® (toothpaste, positive control), Malvatricin® Plus (mouth rinse), PerioGard® (mouth rinse, positive control) or PBS (negative control). Tom's Propolis & Myrrh® and Colgate Total 12® toothpastes and Malvatricin® Plus and PerioGard® mouth rinses significantly reduced biofilm viability (p < 0.05). Only PerioGard® had significant effects on biofilm thickness and EPS. Despite the indication that Tom's Propolis & Myrrh® significantly reduced lesion depth, only Colgate Total 12® significantly reduced mineral loss. Malvatricin® Plus significantly reduced mineral loss and lesion depth, as did PerioGard® . Some herbal products, Malvatricin® Plus and Tom's Propolis & Myrrh® , showed anticaries effects. [ABSTRACT FROM AUTHOR]- Published
- 2019
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59. Biological activity of extracts of traditional wild medicinal plants from the Balkan Peninsula.
- Author
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Vujanović, M., Zengin, G., Đurović, S., Mašković, P., Cvetanović, A., and Radojković, M.
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MEDICINAL plants , *ANTIOXIDANTS , *HERBAL medicine , *PHENOL oxidase , *GLUCOSIDASE inhibitors - Abstract
Abstract The aim of the present study was to investigate antioxidant, cytotoxic and enzyme-inhibitory activities of wild growing medicinal herbs in the Balkan Peninsula (Morus nigra L., Symphytum officinale L., Sambucus nigra L., Teucrium chamaedrys L. and Teucrium montanum L.). Notably, antioxidant activity of investigated plant species was confirmed through several assays including free radical scavenging (ABTS), reducing power (CUPRAC), phosphomolybdenum and metal chelating test. Cytotoxic activity was evaluated using three different cell lines: Hep2c, RD and L2OB. S. officinale L. and S. nigra L. showed the highest cytotoxic activity. All studied extracts exhibited remarkable inhibitory effects on tested enzymes. S. nigra L. and T. chamaedrys L. exhibited the strongest tyrosinase inhibitory effects (26.62 ± 0.77 extract and 14.72 ± 0.41 mg KAEs/g, respectively), while S. officinale L. was the most potent in terms on α-glucosidase inhibition (11.47 ± 0.05 mmol ACAE/g extract). The obtained results indicate that the extracts of the tested wild grown plants could be used which can be explored as natural medicines for the promotion of health. Highlights • The extracts obtained by microwave extraction technique were investigated. • Total phenolic and flavonoid contents were determined. • Enzyme-inhibitory activity was assessed by three different enzyme assays. • Antioxidant activity of extracts was assessed using four different assays. • Cytotoxic activities of obtained extracts were determined. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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60. Multidirectional approaches on autofermented chamomile ligulate flowers: Antioxidant, antimicrobial, cytotoxic and enzyme inhibitory effects.
- Author
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Cvetanović, A., Zeković, Z., Zengin, G., Mašković, P., Petronijević, M., and Radojković, M.
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GERMAN chamomile , *ANTIOXIDANTS , *ANTI-infective agents , *HYDROXYL group , *ENZYMES - Abstract
Abstract In the frame of the present paper the enzymatic transformation of apigenin-glucosides into free aglycone was achieved by autofermentation of chamomile ligulate flowers (CLF). Antioxidant properties of the autofermented CLF (A-CLF) extract were evaluated by their radical scavenging activity against hydroxyl radicals and inhibition of lipid peroxidation. Obtained results showed that A-CLF extract in a concentration of 0.84 mg/mL was able to inhibit 50% of hydroxyl radicals, while IC 50 value in the case of inhibition of lipid peroxidation was 5.21 mg/mL. Antimicrobial activity was done by measuring minimal inhibitory concentration (MIC) values for eight microbial strains. Obtained MIC values (9.75–156.25 μg/mL) confirmed high antibacterial and antifungal activities of the extract. Cytotoxic activity was done by using three histological different cell lines: Hep2C; RD and L2OB. Obtained IC 50 values for these cell lines were: 28.72; 17.31 and 10.92, respectively. Furthermore, in vitro investigation of the A-CLF ability to inhibit selected enzymes (α-amylase, α-glucosidase, tyrosinase) was done as well. Determined activities against α-amylase and α-glucosidase were 0.94 and 3.24 mmol ACAE/g, respectively. Further, measured activity against tyrosinase was 0.69 mg KAEs/g indicating high enzyme-inhibitory activity of examined sample. Results demonstrated that A-CLF extracts showed considerable pharmacological activity. Highlights • Transformation of apigenin glycosides into apigenin by autofermentation of chamomile • Determination of antioxidant properties of extracts • Antimicrobial properties of extracts were examined using six indicator strains. • Using different cell lines cytotoxic activity of examined extracts was determined. • Enzyme-inhibitory activity was determined against amylase, glucosidase and tyrosinase. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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61. Chemical composition and biological activity of Capparis spinosa L. from Lipari Island.
- Author
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Mollica, A., Stefanucci, A., Macedonio, G., Locatelli, M., Luisi, G., Novellino, E., and Zengin, G.
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CAPPARIS spinosa , *CHEMICAL composition of plants , *ANTIOXIDANTS , *CHOLINESTERASES - Abstract
Abstract Several plants belonging to the genus Capparis are the focus of growing interest due to their singular nutritional and medicinal properties. In the present study, flower bud samples from C. spinosa L. (Lipari Island, Italy) were subjected to decoction, Soxhlet, and microwave extraction techniques and the individual extracts investigated to better characterize the phytochemical and antioxidant profiles of the plant. Total phenolic and flavonoid amounts, phenolic composition, radical scavenging as well as reductive and metal chelating properties were determinated by well-established chemical and analytical procedures. Furthermore, cholinesterase inhibitory effects were evaluated by Ellman's method. Fatty acid percentage and essential oil composition were also detected by GC and GC–MS techniques respectively. Rutin was found to be the major component in the studied extracts. The Soxhlet extract exhibited the strongest radical scavenging and reductive activities as compared to the other extracts, most probably due to the highest concentration of phenolics, especially rutin. The best cholinesterase inhibitory effect was observed in the microwave extract. Palmitic acid was the most abundant fatty acid in the studied oil, whereas docosane was the major volatile compound in the essential oil. Present data corroborate the multipurpose potential of C. spinosa for designing bio-based drug formulations or functional applications. Highlights • Lipid profile, essential oils and flavonoids have been analyzed. • Antioxidant activity, metal chelating and radical scavenger properties of Capparis spinosa L. were reported. • Cholinesterase activity for the extracts has been tested. • Different types of extracting methods have been used and compared. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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62. The role of natural anti-parasitic guided development of synthetic drugs for leishmaniasis.
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Pal, Rohit, Teli, Ghanshyam, Akhtar, Md Jawaid, and Matada, Gurubasavaraja Swamy Purawarga
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SYNTHETIC drugs , *LEISHMANIASIS , *DRUG development , *NEGLECTED diseases , *QUINAZOLINE , *PHYTOCHEMICALS , *CHALCONE - Abstract
Leishmaniasis is a parasitic disease and categorised as a neglected tropical disease (NTD). Each year, between 70,0000 and 1 million new cases are believed to occur. There are approximately 90 sandfly species which can spread the Leishmania parasites (over 20 species) causing 20,000 to 30,000 death per year. Currently, leishmaniasis has no specific therapeutic treatment available. The prescribed drugs with several drawbacks including high cost, challenging administration, toxicity, and drug resistance led to search for the alternative treatment with less toxicity and selectivity. Introducing the molecular features like that of phytoconstituents for the search of compounds with less toxicity is another promising approach. The current review classifies the synthetic compounds according to the core rings present in the natural phytochemicals for the development of antileishmanial agents (2020–2022). Considering the toxicity and limitations of synthetic analogues, natural compounds are at the higher notch in terms of effectiveness and safety. Synthesized compounds of chalcones (Compound 8 ; IC 50 : 0.03 μM, 4.7 folds more potent than Amphotericin B; IC 50 : 0.14 μM), pyrimidine (compound 56 ; against L. tropica ; 0.04 μM and L. infantum ; 0.042 μM as compared to glucantime: L. tropica ; 8.17 μM and L. infantum ; 8.42 μM), quinazoline and (compound 72 ; 0.021 μM, 150 times more potent than miltefosine). The targeted delivery against DHFR have been demonstrated by one of the pyrimidine compounds 62 with an IC 50 value of 0.10 μM against L. major as compared to the standard trimethoprim (IC 50 : 20 μM). The review covers the medicinal importance of antileishmanial agents from synthetic and natural sources such as chalcone, pyrazole, coumarins, steroids, and alkaloidal-containing drugs (indole, quinolines, pyridine, pyrimidine, carbolines, pyrrole, aurones, and quinazolines). The efforts of introducing the core rings present in the natural phytoconstituents as antileishmanial in the synthetic compounds are discussed with their structural activity relationship. The perspective will support the medicinal chemists in refining and directing the development of novel molecules phytochemicals-based antileishmanial agents. [Display omitted] • The marketed antileishmanial drugs are associated with toxicity and resistance. • Natural products are promising in treating the leishmanial suffering without the toxic side effects. • Recent developments of natural phytochemicals guided synthesis of potent antileishmanial drugs. • SAR of the different synthesized derivatives to exhibit antileishmanial activity are discussed. [ABSTRACT FROM AUTHOR]
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- 2023
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63. Biological and chemical insights of Morina persica L.: A source of bioactive compounds with multifunctional properties
- Author
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Andrei Mocan, Gokhan Zengin, Ahmet Uysal, Erdogan Gunes, Adriano Mollica, Nurdan Sena Degirmenci, Lokman Alpsoy, and Abdurrahman Aktumsek
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Morina persica ,Cytotoxic ,Natural agents ,Rutin ,Functional ingredients ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Morina persica L. has weak rosy smell flowers that together with aerial parts are infused or decocted and used as a functional tea. It is a representative of the Anatolian traditional medicine and is used for the treatment of cold. Biological and chemical fingerprints of different extracts (methanolic, acetone and water) of M. persica were investigated. Antioxidant, enzyme inhibitory, antimicrobial, cytotoxic and mutagenic/antimutagenic effects were evaluated for biological profiling. Rutin, chlorogenic and rosmarinic acids were detected as dominant compounds. Generally, the methanolic and acetone extracts had strong antioxidant, enzyme inhibitory, antimicrobial and antimutagenic effects. Additionally, all extracts showed remarkable inhibitory effects on HeLa cells at 100 µg/mL. Furthermore, possible interactions between rutin, the dominant phenolic compound in M. persica and the tested enzymes were assessed by molecular docking. Results indicate that M. persica could be considered as a natural source of high-valued functional ingredients for further use in healthful formulations.
- Published
- 2016
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64. Natural Agents Targeting Mitochondria in Cancer
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Shalini Mani, Geeta Swargiary, and Keshav K. Singh
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cancer ,mitochondria ,mitocans ,anticancer herbs ,natural agents ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Mitochondria are the key energy provider to highly proliferating cancer cells, and are subsequently considered one of the critical targets in cancer therapeutics. Several compounds have been studied for their mitochondria-targeting ability in cancer cells. These studies’ outcomes have led to the invention of “mitocans”, a category of drug known to precisely target the cancer cells’ mitochondria. Based upon their mode of action, mitocans have been divided into eight classes. To date, different synthetic compounds have been suggested to be potential mitocans, but unfortunately, they are observed to exert adverse effects. Many studies have been published justifying the medicinal significance of large numbers of natural agents for their mitochondria-targeting ability and anticancer activities with minimal or no side effects. However, these natural agents have never been critically analyzed for their mitochondria-targeting activity. This review aims to evaluate the various natural agents affecting mitochondria and categorize them in different classes. Henceforth, our study may further support the potential mitocan behavior of various natural agents and highlight their significance in formulating novel potential anticancer therapeutics.
- Published
- 2020
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65. Current Evidence of Natural Agents in Oral and Periodontal Health
- Author
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Gaetano Isola
- Subjects
periodontitis ,natural agents ,gingivitis ,antioxidants ,vitamins ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Oral and periodontal diseases, chewing disorders, and many destructive inflammatory diseases of the supporting tissues of the teeth are usually caused by an imbalance between host defense and environmental factors like smoking, poor nutrition, and a high percentage of periodontopathogenic bacteria. For these reasons, it is important also to focus attention on plaque control and also on improving host resistance through smoking and stress reduction, and a healthy diet. During the last decades, the importance of micronutrients has been extensively reviewed, and it was concluded that the prevention and treatment of periodontitis should include correct daily nutrition and a correct balance between antioxidants, probiotics, natural agents, vitamin D, and calcium. Recently, there has been growing interest in the literature on the impact of nutraceutical dietary aliments on oral and general health. This Special Issue provides a current and thoughtful perspective on the relationship of diet and natural agents on oral and periodontal diseases through a correct clinical approach with the last and most important evidence that may determine good oral conditions and high quality of life.
- Published
- 2020
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66. MicroRNAs in Breast Cancer Research: Progress and Promise
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Ahmed, Alia, Ali, Ashhar S., Ali, Shadan, Ahmad, Aamir, Philip, Philip A., Sarkar, Fazlul H., and Ahmad, Aamir, editor
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- 2013
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67. Focusing on the Chemical Characterization, Antioxidant and Cytotoxic Properties of Two Geophytes: Crocus Pallasii and Cyclamen Cilicium
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Gokhan Zengin and Evren Yildiztugay
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crocus ,cyclamen ,antioxidant ,cell assay ,natural agents ,General Works - Abstract
Species of the Crocus and Cyclamen genus have been reported to possess diverse biological properties. In the current work, the antioxidant and cytotoxic effects of the methanolic extracts of C. pallasii and C. cilicium aerial and underground parts were evaluated. The flower extracts of C. pallasii and C. cilicium possessed highest flavonoid content. Highest phenolic content was recorded from C. cilicium root extract (47.62 mg gallic acid equivalent/g extract). C. cilicium root extract showed significantly (p < 0.05) high radical scavenging (94.28 and 139.60 mg trolox equivalent [TE]/g extract, against DPPH and ABTS radicals, respectively) and reducing potential (173.30 and 109.53 mg TE/g extract, against CUPRAC and FRAP, respectively). Methanolic extracts of C. pallasii and C. cilicium showed toxicity against breast cancer cell lines. In the light of the above findings, C. cilicium might be considered as an interesting candidate in the development of anti-cancer agent, possessing antioxidant properties.
- Published
- 2019
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68. A study on Antioxidant Properties of Different Extracts from Kitaibelia balansae
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Gokhan Zengin, Rabia Betul Aygun, and Abdurrahman Aktumsek
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kitaibelia balansae ,antioxidant ,phenolics ,natural agents ,General Works - Abstract
Nowadays, knowledge of ancient botanical medicinal practices and application of modern phytochemical techniques have provided the excellent tools for the purification and structural elucidation of various phyto-compounds, which, in turn, has given insights into their mode of action on the human body. This study has been designed to investigate for the first time the antioxidant effects of the ethyl acetate, methanolic, and water extracts of Kitaibelia balansae. Different chemical methods were performed and the observed abilities depend on the solvent used. The best antioxidant ability was noted in water extract, followed by methanol and ethyl acetate extracts. The highest level of phenolic was also detected in water extract. The present findings suggest that K. balansae can be considered as a potential source of bioactive compounds for novel phytopharmaceuticals development
- Published
- 2019
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69. Study of the Antioxidant, Antimicrobial, and Wound Healing Properties of Raw Hydrolyzed Extract from Nile Tilapia Skin (Oreochromis niloticus).
- Author
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Tozetto R, Santos Rocha B, Assis de Andrade E, Stolz Cruz L, da Rosa RL, Machinski I, Lemos de Oliveira É, Borges Monteiro JR, Koga AY, Cavalcante Lipinski L, Meurer EC, Kitagawa RR, and Beltrame FL
- Subjects
- Animals, Antioxidants pharmacology, Gas Chromatography-Mass Spectrometry, Wound Healing, Cichlids microbiology, Anti-Infective Agents pharmacology
- Abstract
Oreochromis niloticus (Nile tilapia) skin is a by-product of Brazilian fish farming, rich in collagen. The present study aims to evaluate the wound healing, antioxidant, and antimicrobial potential of the raw hydrolyzed extract of Nile tilapia skin, as well as the identification of the main compounds. The in vitro activity was performed using antioxidant, antimicrobial and scratch wound healing assays. An in vivo experiment was performed to evaluate the wound healing potential. On days 1, 7, 14 and 21, the lesions were photographed to assess wound retraction and on the 7
th , 14th and 21st days the skins were removed for histological evaluation and the blood of the animals was collected for glutamic oxaloacetic transaminase and glutamic pyruvic transaminase determination. The chemical study was carried out through liquid chromatography-tandem mass spectrometry and de novo sequencing of peptides. The in vitro assays showed a reduction of the gap area in 24 h, dose-dependent antimicrobial activity for both bacteria, and antioxidant activity. The chemical analysis highlighted the presence of active biopeptides. The histological evaluation showed that the raw hydrolyzed extract of Nile tilapia skin has a healing potential, and does not present toxicological effects; therefore, is promising for the treatment of wounds., (© 2023 Wiley-VHCA AG, Zurich, Switzerland.)- Published
- 2023
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70. Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: a multi-functional insight.
- Author
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Zengin, Gokhan, Uysal, Ahmet, Diuzheva, Alina, Gunes, Erdogan, Jekő, József, Cziáky, Zoltán, Picot-Allain, Carene Marie Nancy, and Mahomoodally, Mohamad Fawzi
- Subjects
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FERULA , *PLANT extracts , *PHYTOCHEMICALS , *HIGH performance liquid chromatography , *TANDEM mass spectrometry - Abstract
Highlights • Chemical composition and biological effect of Ferula halophila extracts were investigated. • Antioxidant, antimutagenic and enzyme inhibitory effects were tested for biological potentials. • HPLC-MS/MS analysis revealed the presence of cinnamic acid derivatives such as methyl cinnamete and ferulic acid. • F. halophila has a good pharmacological potential for designing novel drug formulations. Abstract The inhibitory action of F. halophila extracts (acetone, chloroform, and methanol) against key enzymes linked to diabetes (α-amylase, α-glucosidase), cognitive functions (acetyl cholinesterase (AChE), butyryl cholinesterase (BChE)), and hyperpigmentation (tyrosinase) was assessed. The mutagenic/antimutagenic activities were assessed and the phytochemical profile established by HPLC-MS/MS. The acetone extract showed the highest phenolic (55.22 mg GAE/g extract) and flavonoid (34.52 mg RE/g extract) contents. The chloroform extract was a potent inhibitor of cholinesterases (4.86 and 6.13 mg GALAE/g extract, against AChE and BChE, respectively). Cinnamic acid derivatives (methyl cinnamate, ferulic acid, methoxycinnamic acid isomer) were identified in the chloroform extract. Methanol extract showed potent inhibitory action against tyrosinase (137.63 mg KAE/g extract) and glucosidase (43.02 mmol ACAE/g extract). The chloroform extract (32.07 mg EDTAE/g extract) showed potent metal chelating potential. The neuroprotective action of the chloroform extract might be attributed to the metal chelating action coupled by the cholinesterase inhibitory potential. F. halophila showed no mutagenic capacity. When combined with 2-aminoflouren and 2-aminoanthracene, the acetone and chloroform extracts revealed excellent antimutagenicity in the presence of metabolic activation enzymes for Salmonella typhimurium TA98 and TA100 strains. The observed inhibitory effects of F. halophila against the studied enzyme suggest that this plant could be a promising source of bioactive phytochemicals for the management of clinical conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
71. Natural agents in the management of oral mucositis in cancer patients-systematic review.
- Author
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Nagi, Ravleen, Patil, Deepa Jatti, Rakesh, N., Jain, Supreet, and Sahu, Shashikant
- Abstract
Introduction Oral mucositis is most severe complication of cancer therapy characterized by ulcerative lesions of oral mucosa causing negative impact on patient's quality of life. Wide variety of therapeutic agents are available to reduce the lesions of mucositis. Currently, natural herbal remedies have become popular in treating this condition due to fewer side effects than synthetic drugs. Aim The aim of this systematic review is to compile evidence based studies to evaluate the effectiveness of natural agents in the management of oral mucositis induced by chemotherapy or radiotherapy in cancer patients. Materials and method Computerized literature searches were performed to identify all published articles in the subject. The following databases were used: PUBMED [MEDLINE], SCOPUS, COCHRANE DATABASE, EMBASE and SCIENCE DIRECT using specific keywords. The search was for limited articles published in English which were read in full by two authors. Results Twenty six randomized controlled trials satisfied our inclusion criteria. Most studies showed statistically significant result demonstrating the efficacy of natural agents with minimal side effects except manuka honey which was not tolerated by few patients. Conclusion Natural agents proved to be promising in healing cancer induced oral mucositis but future demands further randomized controlled clinical trials on these agents which should also be focused on drug interactions of the natural remedies. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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72. On Minimal Autonomous Agency: Natural and Artificial.
- Author
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Moreno, Alvaro
- Subjects
AGENT (Philosophy) ,AUTONOMY (Philosophy) ,SYNTHETIC biology ,HUMAN behavior ,ORIGIN of life - Abstract
The idea of minimal agency (MA) may be understood as the simplest agent within the known phenomenological domain, that is, the simplest agent as-we-know-it, and as the simplest agent that could exist, either synthetically or in a hypothetical process of biogenesis, that is, the simplest agent as-it-should-be. The second view is more radical, since it focuses on the simplest organizational and material conditions required for generating agential capacities, not on how they are in fact minimally instantiated. It searches for the simplest material building blocks that, either naturally or artificially, could achieve the simplest form of organization necessary to display agency. Yet, although synthetic methodologies may seem a more adequate strategy to generate minimal forms of agency, I argue that the study of how the biological domain has generated agents is ultimately necessary to understand paradoxical cases of minimal agents and shows us fundamental lessons for their artificial fabrication. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
73. Multidirectional investigations on different parts of Allium scorodoprasum L. subsp. rotundum (L.) Stearn: Phenolic components, in vitro biological, and in silico propensities.
- Author
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Mollica, Adriano, Zengin, Gokhan, Locatelli, Marcello, Picot-Allain, Carene Marie Nancy, and Mahomoodally, Mohamad Fawzi
- Subjects
- *
ALLIUM , *PLANT phenols , *PLANT species , *MEDICINAL plants , *ENZYME inhibitors - Abstract
Allium species have been widely used for culinary and medicinal purposes. This study attempts for the first time to investigate into the enzyme inhibitory potential of different plant parts of Allium scorodoprasum L. subsp. rotundum (L.) Stearn, also known as wild garlic or leek in Turkey. The antioxidant and enzyme inhibitory potential of the flower, stem, and bulb extracts of A. scorodoprasum were assessed using in vitro bio-assays. The phenolic composition of the different plant parts was also established. The flower extract, having high phenolic content (27.69 mg GAEg extract), showed potent antioxidant activity as a metal chelating agent (22.27 mg EDTAE/g extract), radical scavenger (34.83 and 66.02 mg trolox equivalent (TE)/g extract, for 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) assays, respectively) and reducing agent (90.53 mg TE/g extract, for the cupric reducing antioxidant capacity assay). Besides, the flower extract was a potent inhibitor of butyrylcholinesterase (3.16 mg galantamine equivalent (GALAE)/g extract) and tyrosinase (55.21 mg kojic acid equivalent/g extract). The flower extract was rich in rosmarinic acid. In silico studies revealed that rosmarinic acid established several hydrogen bonds and π–π interactions in the enzymatic cavity of butyrylcholinesterase. On the other hand, the stem extract of A. scorodoprasum showed inhibitory action against acetylcholinesterase (2.17 mg GALAE/g extract) and α-amylase (0.55 mmol acarbose equivalent/g extract). Interestingly, we noted that the bulb extract of A. scorodoprasum , inferior in phenolic compounds, showed the least activity. These results suggest that the different plant parts of A. scorodoprasum possessed different biological activities and might be used as a medicinal food plants for specific therapeutic applications. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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74. Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties.
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Zengin, Gokhan, Mahomoodally, M. Fawzi, Aktumsek, Abdurrahman, Ceylan, Ramazan, Uysal, Sengul, Mocan, Andrei, Yilmaz, Mustafa Abdullah, Picot-Allain, Carene Marie Nancy, Ćirić, Ana, Glamočlija, Jasmina, and Soković, Marina
- Subjects
ANTIOXIDANTS ,BIOACTIVE compounds ,PHYTOCHEMICALS - Abstract
Six wild species ( S. alba , S. conoidea , S. dichotoma, S. italica, S. supina , and S. vulgaris ) from the Silene genera were tested for potential anti-enzymatic (acetyl cholinesterase (AChE), butyryl cholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase), antimicrobial (16 microbial strains), and antioxidant activity. An ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry method was used for phytochemical determination. Quinic acid, malic acid, protocatechuic acid, p -coumaric acid, and hesperidin were common in the six Silene species. All extracts showed higher antibacterial effects compared to streptomycin and ampicillin (except S. dichotoma ). Antifungal agents, bifonazole (MIC 0.10–0.20 mg/mL and MFC 0.20–0.30 mg/mL) and ketoconazole (MIC 0.15–2.30 mg/mL and MFC 0.20–3.50 mg/mL) showed lower activity than the investigated Silene species extracts. S. alba inhibited AChE (2.00 mg GALAE/g extract) and BChE (1.0 mg GALAE/g extract). The results showed metal chelating potential ranging from 12 to 19 mg EDTAE/g extract, with S. conoidea being the most active, and S. supina the least. S. dichotoma showed the highest reducing potential against both cupric (154 mg TE/g extract for CUPRAC) and ferric (102 mg TE/g extract for FRAP) ions. Overall, Silene species could be considered as emerging interesting functional foods and sources of nutraceuticals with applications in the management of different diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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75. Prostate cancer chemoprevention by natural agents: Clinical evidence and potential implications.
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Chhabra, Gagan, Singh, Chandra K., Ndiaye, Mary Ann, Fedorowicz, Samantha, Molot, Arielle, and Ahmad, Nihal
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PROSTATE cancer prevention , *CHEMOPREVENTION , *CANCER-related mortality , *NATURAL products , *CANCER invasiveness - Abstract
Prostate cancer (PCa) is the most common non-skin cancer and the second leading cause of cancer-related deaths in American men. Due to its long latency period, PCa is considered as an ideal cancer type for chemopreventive interventions. Chemopreventive agents include various natural or synthetic agents that prevent or delay cancer development, progression and/or recurrence. Pre-clinical studies suggest that many natural products and dietary agents have chemopreventive properties. However, a limited number of these agents have been tested in clinical trials, with varying success. In this review, we have discussed the available clinical studies regarding the efficacy of natural chemopreventive agents against PCa, including tea polyphenols, selenium, soy proteins, vitamins and resveratrol. We have also provided a discussion on the clinical challenges and opportunities for the potential use of chemopreventive agents against PCa. Based on available literature, it appears that the variable outcomes of the chemopreventive clinical studies necessitate a need for additional studies with more rigorous designs and methodical interpretations in order to measure the potential of the natural agents against PCa. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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76. Biological, chemical and in silico fingerprints of Dianthus calocephalus Boiss.: A novel source for rutin.
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Uysal, Sengul, Aktumsek, Abdurrahman, Unuvar, Hamiyet, Zengin, Gokhan, Picot-Allain, Carene M.N., Mahomoodally, Mohamad Fawzi, Mollica, Adriano, and Georgiev, Milen I.
- Subjects
- *
PINKS (Plants) , *RUTIN , *PHENOLS , *PHENOL analysis , *CHOLINESTERASES , *PHENOL oxidase - Abstract
Extracts (methanol, ethyl acetate, and water) from Dianthus calocephalus Boiss. prepared by different extraction techniques (maceration, Soxhlet, and ultrasonication) were studied for possible inhibitory action against key enzymes (α-amylase, α-glucosidase, acetyl cholinesterase, butyryl cholinesterase, and tyrosinase). Antioxidant potential was established using a battery of assays and phenolic compounds profiled by RP-HPLC. Binding pose of tyrosinase with rutin was studied by means of molecular docking. Methanol extracts showed the highest phenolic (39.35–40.25 mgGAE/g) content and rich in rutin (61.38–72.07 mg/g extract). Ethyl acetate extracts of D. calocephalus were potent inhibitors of acetyl (1.45–1.48 mgGALAE/g) and butyryl (2.44–2.74 mgGALAE/g) cholinesterases. Docking studies showed that rutin interacts with the side chains of the key amino acid residues and to the copper atom found at the active site of tyrosinase. Methanol extracts showed highest antioxidant capacity. D. calocephalus showed interesting biological properties that could be further studied to manage diabetes, neurodegenerative diseases, Alzheimer's disease, and hyperpigmentation. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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77. Natural Agents-Mediated Targeting of Histone Deacetylases.
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Farooqi, Ammad, Naqvi, Syed, Perk, Aliye, Yanar, Onur, Tabassum, Sobia, Ahmad, Muhammad, Mansoor, Qaisar, Ashry, Mohamed, Ismail, Muhammad, Naoum, George, and Arafat, Waleed
- Abstract
In the past few years, basic and clinical scientists have witnessed landmark achievements in many research projects, such as those conducted by the US National Institutes of Health Roadmap Epigenomics Mapping Consortium, the International Human Epigenome Consortium, The Cancer Genome Atlas Network and the International Cancer Genome Consortium, which have provided near-complete resolution of epigenetic landscape in different diseases. Furthermore, genome sequencing of tumors has provided compelling evidence related to frequent existence of mutations in readers, erasers and writers of epigenome in different cancers. Histone acetylation is an intricate mechanism modulated by two opposing sets of enzymes and deeply studied as a key biological phenomenon in 1964 by Vincent Allfrey and colleagues. The research group suggested that this protein modification contributed substantially in transcriptional regulation. Subsequently, histone deacetylases (HDACs), histone acetyltransferases and acetyl-Lys-binding proteins were identified as transcriptional mediators, which further deepened our comprehension regarding biochemical modifications. Overwhelmingly increasing high-impact research is improving our understanding of this molecularly controlled mechanism; moreover, quantification and identification of lysine acetylation by mass spectrometry has added new layers of information. We partition this multi-component review into how both activity and expression of HDAC are targeted using natural agents. We also set spotlight on how oncogenic fusion proteins tactfully utilize HDAC-associated nano-machinery to modulate expression of different genes and how HDAC inhibitors regulate TRAIL-induced apoptosis in cancer cells. HDAC inhibitors have been reported to upregulate expression of TRAIL receptors and protect TRAIL from proteasomal degradation. Deeper understanding of HDAC biology will be useful for stratification and selection of patients who are responders, non-responders and poor-responders for HDACi therapy, and for the rational design of combination studies using HDACi. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
78. Amides from Zanthoxylum bungeanum Maxim. (Rutaceae) are promising natural agents with neuroprotective activities.
- Author
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Li, Ruo-Lan, Duan, Hu-Xinyue, Wang, Ling-Yu, Liang, Qi, Wu, Chunjie, and Peng, Wei
- Abstract
Neurodegenerative diseases are neurological diseases that are characterized by neuronal degeneration and apoptosis; they threaten populations around the world and place a great burden on the social economy. Unfortunately, the drugs currently used to treat neurodegenerative diseases have obvious side effects, making them much less effective. Therefore, discovery of new safe and effective drugs is urgently needed. Zanthoxylum bungeanum Maxim. (ZBM) has a long medicinal history in China and can also be used as food. ZBM contains many types of chemical components, of which amides are the most abundant. In preparing this review, we searched and integrated the relevant literature in PubMed, Web of Science, Elesvier, Wliey and Springer using the keywords "ZBM", "amide", "physicochemical properties", and "neurodegenerative diseases". It was found that the amides that are present in ZBM (AZB), although structurally unstable, are the likely material basis for an irritating sensation in the mout,. In addition, AZB can play a therapeutic role in Alzheimer's disease, Parkinson's and depression by exerting antioxidant and anti-inflammatory effects. The main targets of AZB are the TRPV1, TRPA1 and PI3K/AKT signalling pathways. This review will discuss the physical and chemical properties of AZB and its use in the treatment of neurodegenerative diseases to provide a reference for the development of ZBM for use in the treatment of neurodegenerative diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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79. A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica
- Author
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Serife Yerlikaya, Gokhan Zengin, Adriano Mollica, Mehmet C. Baloglu, Yasemin Celik Altunoglu, and Abdurrahman Aktumsek
- Subjects
Ononis ,bioactive compounds ,natural agents ,pharmaceuticals ,molecular docking ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The genus Ononis has important value as traditional drugs and foods. In the present work, we aimed to assess the chemical profiles and biological effects of Ononis natrix subsp. hispanica extracts (ethyl acetate, methanol, and water). For chemical profile, total and individual phenolic components were detected. For biological effects, antioxidant (DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating assays), enzyme inhibitory (against cholinesterase, tyrosinase, α-amylase and α-glucosidase), antimicrobial, DNA protection and cytotoxic abilities were tested. The predominant phenolics were apigenin, luteolin, and quercetin in the tested extracts. Generally, the ethyl acetate and methanol extracts were noted as the most active in the antioxidant and enzyme inhibitory assays. Water extract with different concentrations indicated high level of DNA protection activity. Methanol and ethyl acetate extracts showed antibacterial effect against to Staphylococcus aureus and Staphylococcus epidermidis strains. The cytotoxic effects of O. natrix subsp. hispanica extracts on the survival of HeLa and PC3 cells were determined by MTT cell viability assay. Water and methanol extracts caused initiation of apoptosis for PC3 cell line. Furthermore, molecular docking was performed to better understand interactions between dominant phenolic compounds and selected enzymes. Our results clearly indicate that O. natrix subsp. hispanica could be considered a potential candidate for designing novel pharmaceuticals, cosmeceuticals and nutraceuticals.
- Published
- 2017
- Full Text
- View/download PDF
80. Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment.
- Author
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Pandey, Manoj K., Gupta, Subash C., Nabavizadeh, Ali, and Aggarwal, Bharat B.
- Subjects
- *
PHYSIOLOGICAL aspects of food habits , *POLYPHENOLS , *PEROXISOME proliferator-activated receptors , *TRANSCRIPTION factors , *KINASES - Abstract
Although it is widely accepted that better food habits do play important role in cancer prevention and treatment, how dietary agents mediate their effects remains poorly understood. More than thousand different polyphenols have been identified from dietary plants. In this review, we discuss the underlying mechanism by which dietary agents can modulate a variety of cell-signaling pathways linked to cancer, including transcription factors, nuclear factor κB (NF-κB), signal transducer and activator of transcription 3 (STAT3), activator protein-1 (AP-1), β-catenin/Wnt, peroxisome proliferator activator receptor- gamma (PPAR-γ), Sonic Hedgehog, and nuclear factor erythroid 2 (Nrf2); growth factors receptors (EGFR, VEGFR, IGF1-R); protein Kinases (Ras/Raf, mTOR, PI3K, Bcr-abl and AMPK); and pro-inflammatory mediators (TNF-α, interleukins, COX-2, 5-LOX). In addition, modulation of proteasome and epigenetic changes by the dietary agents also play a major role in their ability to control cancer. Both in vitro and animal based studies support the role of dietary agents in cancer. The efficacy of dietary agents by clinical trials has also been reported. Importantly, natural agents are already in clinical trials against different kinds of cancer. Overall both in vitro and in vivo studies performed with dietary agents strongly support their role in cancer prevention. Thus, the famous quote “Let food be thy medicine and medicine be thy food” made by Hippocrates 25 centuries ago still holds good. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
81. Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches.
- Author
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Zengin, Gokhan, Bulut, Gizem, Mollica, Adriano, Haznedaroglu, Mehmet Zeki, Dogan, Ahmet, and Aktumsek, Abdurrahman
- Subjects
- *
YARROW , *BUPLEURUM , *BIOACTIVE compounds , *ANTIOXIDANTS , *ENZYME inhibitors - Abstract
This study presents the effects of the Achillea phrygia Boiss. et Bal. and Bupleurum croceum Fenzl. extracts obtained by different solvents (ethyl acetate, methanol and water) on selected enzyme inhibitory effects and antioxidant ability with screening bioactive compounds. Total and individual bioactive compounds were detected by spectrophotometric and HPLC-DAD techniques. Antioxidant abilities were evaluated by different methods including free radical scavenging (ABTS and DPPH), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating. Enzyme inhibitory effects were tested against cholinesterases, tyrosinase, amylase, glucosidase and lipase. Total phenolic contents were ranged from 20.52 mgGAE/g extract ( B. croceum methanol extract) to 41.13 mgGAE/g extract ( A. phrygia methanol extract). Generally, methanol and water extracts showed the strongest antioxidant abilities, while the ethyl acetate extracts had the most promising enzyme inhibitory effects. HPLC analysis revealed the abundance of some phenolics including rutin, quercetin, sinapic acid and chlorogenic acid, respectively. These components were also assessed using molecular modelling with the aim to study their docking properties on a set of six enzymes used in this study. Overall, these species could be suggested as valuable sources of natural-bioactive agents for developing new functional, pharmacological and health-promoting ingredients. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
82. Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer.
- Author
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Marucci, Laura, Farneti, Alessia, Di Ridolfi, Paolo, Pinnaro, Paola, Pellini, Raul, Giannarelli, Diana, Vici, Patrizia, Conte, Mario, Landoni, Valeria, and Sanguineti, Giuseppe
- Subjects
CANCER chemotherapy ,MUCOSITIS ,MUCOUS membrane diseases ,HEAD & neck cancer ,OTOLARYNGOLOGY - Abstract
Background There is no widely accepted intervention in the prevention of acute mucositis during chemoradiotherapy for head and neck carcinoma. In the present double-blind study, we tested 4 natural agents, propolis, aloe vera, calendula, and chamomile versus placebo. Methods Patients undergoing concomitant chemo-intensity-modulated radiotherapy (IMRT) were given natural agent or matched placebo; grade 3 mucositis on physical examination according to Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 was the primary endpoint. Various covariates were tested at logistic regression, including the individual amount of mucosa receiving at least 9.5 Gy per week (V9.5w). Results One hundred seven patients were randomized from January 2011 to July 2014, and 104 were assessable (51%-49% were assigned to the placebo group and 53%-51% were assigned to the natural agent). Overall, 61 patients developed peak grade 3 mucositis with no difference between arms ( P = .65). Conversely, V9.5w ( P = .007) and primary site ( P = .037) were independent predictors. Conclusion The selected natural agents do not prevent mucositis, whereas the role of V9.5w is confirmed. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
83. A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica.
- Author
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Yerlikaya, Serife, Zengin, Gokhan, Mollica, Adriano, Baloglu, Mehmet C., Altunoglu, Yasemin Celik, and Aktumsek, Abdurrahman
- Subjects
BIOACTIVE compounds ,ANTIOXIDANTS ,ETHYL acetate - Abstract
The genus Ononis has important value as traditional drugs and foods. In the present work, we aimed to assess the chemical profiles and biological effects of Ononis natrix subsp. hispanica extracts (ethyl acetate, methanol and water). For chemical profile, total and individual phenolic components were detected. For biological effects, antioxidant (DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum and metal chelating assays), enzyme inhibitory (against cholinesterase, tyrosinase, α-amylase and α-glucosidase), antimicrobial, DNA protection and cytotoxic abilities were tested. The predominant phenolics were apigenin, luteolin and quercetin in the tested extracts. Generally, the ethyl acetate and methanol extracts were noted as the most active in the antioxidant and enzyme inhibitory assays. Water extract with different concentrations indicated high level of DNA protection activity. Methanol and ethyl acetate extracts showed antibacterial effect against to Staphylococcus aureus and Staphylococcus epidermidis strains. The cytotoxic effects of O. natrix subsp. hispanica extracts on the survival of HeLa and PC3 cells were determined by MTT cell viability assay. Water and methanol extracts caused initiation of apoptosis for PC3 cell line. Furthermore, molecular docking was performed to better understand interactions between dominant phenolic compounds and selected enzymes. Our results clearly indicate that O. natrix subsp. hispanica could be considered a potential candidate for designing novel pharmaceuticals, cosmeceuticals and nutraceuticals. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
84. Application of cinnamon bark emulsions to protect strawberry jam from fungi.
- Author
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Ribes, Susana, Fuentes, Ana, Talens, Pau, and Barat, Jose Manuel
- Subjects
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CINNAMON , *EMULSIONS , *JAM (Preserves) , *XANTHAN gum , *ANTI-infective agents - Abstract
The objective of the work was to evaluate the use of cinnamon bark-xanthan gum emulsions to preserve strawberry jam. The optimisation of the methodology used to prepare the emulsions and, the evaluation of their antimicrobial activity in culture media and in the strawberry jam were investigated. Emulsions were prepared in either a rotor-stator homogeniser or a magnetic stirrer combined with a high pressure homogeniser. Microorganism suspensions (10 3 and 10 6 CFU/mL), essential oil concentration and microbial sensitivity were decisive in the emulsions’ antimicrobial activity. The high stress applied to samples and their heating during homogenisation caused essential oil content losses. The jams prepared with the oil-in-water emulsions inoculated with Aspergillus flavus, Penicillium expansum, Zygosaccharomyces rouxii and Zygosaccharomyces bailii exhibited no growth during the 28 days of analysis The obtained results indicated the suitability of cinnamon bark oil-xanthan gum emulsions for preserving strawberry jam. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
85. MicroRNAs mediate therapeutic and preventive effects of natural agents in breast cancer.
- Author
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LIANG, Zhipin and XI, Yaguang
- Abstract
MicroRNAs (miRNAs) are a set of non-coding small RNA molecules that play a critical role in regulation of protein coding genes in cells. MiRNAs have been extensively studied as novel biomarkers, therapeutic targets, and new drugs in various human diseases. Breast cancer is a one of the leading tumor types significantly affecting women health worldwide. Over the past decade, a number of natural agents, such as paclitaxel and curcumin, have been applied for treatment and prevention of breast cancer due to their relatively low toxicity. However, the mechanisms of action have not been completely understood. Investigation on miRNAs is able to potentially provide a novel insight into better understanding the anticancer activities of these natural products. Given that a single miRNA can target multiple genes, theoretically, those genes involved in a certain phenotype can be clustered with one or a few miRNAs. Therefore, pleiotropic activities of natural agents should be interpreted by interactions between selected miRNAs and their targets. In this review, we summarize the latest publications related to the alterations of miRNAs by two natural agents (paclitaxel and curcumin) that are currently used in intervention of breast cancer, and conclude that the mechanism involving the regulation of miRNA expression is one of the keys to understand pleiotropic activities of natural agents. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
86. Impact of natural agents on buildings and remedial approach- An overview
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Srihari, V. and Das, Ashutosh
- Published
- 2010
87. PENGENDALIAN SERANGAN GANODERMA SPP. (60-80%) PADA TANAMAN SENGON SEBAGAI PELINDUNG TANAMAN KOPI DAN KAKAO
- Author
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Elis Nina Herliyana, Darmono Taniwiryono, Hayati Minarsih, Muhammad Alam Firmansyah, and Benyamin Dendang
- Subjects
Genetic variation ,sengon ,natural agents ,Trichoderma ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
Information about genetic variation of Ganoderma spp. As a cause of rot disease on plantation crops is necessary for consideration in efforts to protect crops. Exploration of the use of biological agents, especially Trichoderma spp., For the control of Ganoderma on forestry crops is still limited to laboratory testing. Its effectiveness to control Trichoderma spp. To protect plants in the nursery sengon being carried out, as well as to determine its role in improving plant growth
- Published
- 2011
88. The Hunt for Natural Skin Whitening Agents
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Stan Pavel, Nico Smit, and Jana Vicanova
- Subjects
whitening ,tyrosinase inhibitors ,natural agents ,cosmetics ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Skin whitening products are commercially available for cosmetic purposes in order to obtain a lighter skin appearance. They are also utilized for clinical treatment of pigmentary disorders such as melasma or postinflammatory hyperpigmentation. Whitening agents act at various levels of melanin production in the skin. Many of them are known as competitive inhibitors of tyrosinase, the key enzyme in melanogenesis. Others inhibit the maturation of this enzyme or the transport of pigment granules (melanosomes) from melanocytes to surrounding keratinocytes. In this review we present an overview of (natural) whitening products that may decrease skin pigmentation by their interference with the pigmentary processes.
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- 2009
- Full Text
- View/download PDF
89. The Potential Application of Chinese Medicine in Liver Diseases: A New Opportunity
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Honglin Zhou, Yunxia Li, Ke Fu, Cheng Ma, and Cheng Wang
- Subjects
Alcoholic liver disease ,liver diseases ,Disease ,Traditional Chinese medicine ,RM1-950 ,Review ,Gut flora ,Bioinformatics ,Liver disease ,Immune system ,medicine ,potential application ,Pharmacology (medical) ,Pharmacology ,clinical trials ,biology ,Chinese medicine ,business.industry ,Fatty liver ,toxicity ,medicine.disease ,biology.organism_classification ,Therapeutics. Pharmacology ,Liver cancer ,business ,natural agents - Abstract
Liver diseases have been a common challenge for people all over the world, which threatens the quality of life and safety of hundreds of millions of patients. China is a major country with liver diseases. Metabolic associated fatty liver disease, hepatitis B virus and alcoholic liver disease are the three most common liver diseases in our country, and the number of patients with liver cancer is increasing. Therefore, finding effective drugs to treat liver disease has become an urgent task. Chinese medicine (CM) has the advantages of low cost, high safety, and various biological activities, which is an important factor for the prevention and treatment of liver diseases. This review systematically summarizes the potential of CM in the treatment of liver diseases, showing that CM can alleviate liver diseases by regulating lipid metabolism, bile acid metabolism, immune function, and gut microbiota, as well as exerting anti-liver injury, anti-oxidation, and anti-hepatitis virus effects. Among them, Keap1/Nrf2, TGF-β/SMADS, p38 MAPK, NF-κB/IκBα, NF-κB-NLRP3, PI3K/Akt, TLR4-MyD88-NF-κB and IL-6/STAT3 signaling pathways are mainly involved. In conclusion, CM is very likely to be a potential candidate for liver disease treatment based on modern phytochemistry, pharmacology, and genomeproteomics, which needs more clinical trials to further clarify its importance in the treatment of liver diseases.
- Published
- 2021
90. Centaurea pterocaula özütlerinin antioksidan ve antimutajenik özellikleri ile enzim inhibitör potansiyellerinin incelenmesi.
- Author
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UYSAL, Ahmet, ZENGİN, Gökhan, DURAK, Yusuf, and AKTÜMSEK, Abduhrraman
- Abstract
The purpose of this study was to evaluate the antioxidant capacities, mutagenic/antimutagenic propeties and enzyme inhibitory effects of three extracts (ethyl acetate, methanol and water) of Centaurea pterocaula. The antioxidant properties were investigated using in vitro antioxidant methods such as radical scavenging (DPPH assay), reducing power (FRAP and CUPRAC assays), phosphomolybdenum and metal chelating activity. Enzyme inhibitory effects were tested aganist cholinesterase, tyrosinase, amylase and glucosidase. Ames test was used to show mutagenic/antimutagenic properties of these extracts. Methanol extract had the strongest free radical scavenging (31.06 mgTE/g extract) and reducing power abilities (66.95 mgTE/g extract for CUPRAC and 51.03 mgTE/g extract for FRAP). Also, ethyl acetate extract exhibited the strongest effect on the tested enzymes (except for glucosidase). Total phenolic and flavonoid contents were found to be 15.77-25.22 mg GAE/g extract and 0.67-31.44 mg RE/g extract, respectively. The mutagenicity was not seen for all extracts tested, while it was determined that some samples had significant antimutagenicity. In the condition of presence of S9 mix, ethyl acetate and methanol extracts revealed excellent antimutagenic activity (92% and 92%) at a dose of 5000 µg/plate against 2-aminoflourene (2-AF) for TA98 strain. According to the results of the present study, C. pterocaula can be considered as a potential source for developing new nutraceuticals or pharmaceuticals. [ABSTRACT FROM AUTHOR]
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- 2016
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91. Biological and chemical insights of Morina persica L.: A source of bioactive compounds with multifunctional properties.
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Mocan, Andrei, Zengin, Gokhan, Uysal, Ahmet, Gunes, Erdogan, Mollica, Adriano, Degirmenci, Nurdan Sena, Alpsoy, Lokman, and Aktumsek, Abdurrahman
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Morina persica L. has weak rosy smell flowers that together with aerial parts are infused or decocted and used as a functional tea. It is a representative of the Anatolian traditional medicine and is used for the treatment of cold. Biological and chemical fingerprints of different extracts (methanolic, acetone and water) of M. persica were investigated. Antioxidant, enzyme inhibitory, antimicrobial, cytotoxic and mutagenic/antimutagenic effects were evaluated for biological profiling. Rutin, chlorogenic and rosmarinic acids were detected as dominant compounds. Generally, the methanolic and acetone extracts had strong antioxidant, enzyme inhibitory, antimicrobial and antimutagenic effects. Additionally, all extracts showed remarkable inhibitory effects on HeLa cells at 100 µg/mL. Furthermore, possible interactions between rutin, the dominant phenolic compound in M. persica and the tested enzymes were assessed by molecular docking. Results indicate that M. persica could be considered as a natural source of high-valued functional ingredients for further use in healthful formulations. [ABSTRACT FROM AUTHOR]
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- 2016
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92. Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
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Tiwari, Prakash, Sahay, Satya, Pandey, Manuraj, Qadri, Syed S.Y.H., and Gupta, Krishna P.
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BUTYRIC acid , *NICOTINAMIDE , *TOLIDINE , *NEOPLASTIC cell transformation , *ANTHRACENE , *LABORATORY mice , *MICRORNA - Abstract
Skin cancer is among the most common cancers worldwide and identifiable molecular changes for early and late stage of skin tumorigenesis can suggest the better targets for its control. In this study, we investigated the status of K-Ras-PI3K-AKTpathway followed by NF-κB, cyclin D1, MMP-9 and regulatory micro RNA during 7, 12-dimethylbenz[a]anthracene (DMBA) induced mouse skin tumorigenesis and its prevention by butyric acid (BA), nicotinamide (NA) and calcium glucarate (CAG), individually or in combination with respect to time. DMBA upregulated the K-Ras, PI3K, Akt, NF-κB, cyclin D1 and MMP-9, but downregulated the PTEN in a time dependent manner. DMBA also reduced the levels of micoRNA let-7a but induced the levels of miR-21 and miR-20a as a function of time. BA, NA and CAG were found to prevent DMBA induced changes, but they were most effective when used together in a combination. Reduced let-7a and miR-211 were correlated with the overexpression of K-Ras and MMP-9. Overexpression of miR-21 and miR-20a was correlated with the down regulation of PTEN and overexpression of Cyclin D1. Collectively, the enhanced chemopreventive potential of natural compound in combination via regulation of K-Ras-PI3K-AKTpathway along with regulatory micro RNAs provide a newer and effective mean for cancer management. [ABSTRACT FROM AUTHOR]
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- 2016
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93. Restoring E-cadherin Expression by Natural Compounds for Anticancer Therapies in Genital and Urinary Cancers
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Xueqiong Zhu, Yizuo Song, Miaomiao Ye, Junhan Zhou, and Zhiwei Wang
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0301 basic medicine ,Cancer Research ,Urinary system ,Cancer therapy ,lcsh:RC254-282 ,Article ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,medicine ,cancer ,Pharmacology (medical) ,Sex organ ,therapy ,Cadherin ,business.industry ,EMT ,Cancer ,E-cadherin ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,invasion ,Clinical trial ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,Molecular Medicine ,Signal transduction ,business ,natural agents - Abstract
E-cadherin plays a pivotal role in cancer progression, including the epithelial-mesenchymal transition (EMT) process and tumor metastasis. Loss of E-cadherin contributes to enhanced invasion and metastasis in human cancers. Therefore, restoring E-cadherin could be a potential approach for cancer therapy. Multiple natural compounds have been shown to possess anti-tumor activities through the regulation of key molecules in signaling pathways, including E-cadherin. In this review, we describe the numerous compounds that restore the expression of E-cadherin in genital and urinary malignancies. We further discuss the potential anti-tumor molecular mechanisms of these agents as the activators of E-cadherin in genital and urinary cancers. Although these compounds exhibit their potential to inhibit the development and progression of cancers, there are several challenges to developing them as therapeutic drugs for cancer patients. Poor bioavailability in vivo is the main disadvantage of these compounds. Modification of compound structures has produced actual improvements in bioavailability. Nanoparticle-based delivery systems could be useful to deliver the agents to targeted organs. These compounds could be new promising therapeutic agents for the treatment of human genital and urinary cancers. Further investigations are required to determine the safety and side effects of natural compounds using animal models prior to clinical trials. Keywords: E-cadherin, EMT, invasion, cancer, natural agents, therapy
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- 2019
94. Multidirectional approaches on autofermented chamomile ligulate flowers: Antioxidant, antimicrobial, cytotoxic and enzyme inhibitory effects
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Mirjana Petronijević, Gokhan Zengin, Marija Radojković, Aleksandra Cvetanović, Pavle Mašković, Zoran Zeković, Selçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, and Zengin, Gökhan
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0106 biological sciences ,Antioxidant ,Doğal ajanlar ,medicine.medical_treatment ,Tyrosinase ,Plant Science ,01 natural sciences ,Lipid peroxidation ,03 medical and health sciences ,chemistry.chemical_compound ,Minimum inhibitory concentration ,0302 clinical medicine ,Otomatik fermantasyon ,Natural agents ,medicine ,Enzim inhibitörleri ,Food science ,IC50 ,2. Zero hunger ,Chemistry ,Biological activity ,Chamomile ,Enzyme-inhibitions ,Antimicrobial ,Autofermentation ,3. Good health ,Biyolojik aktivite ,Aglycone ,Papatya ,030220 oncology & carcinogenesis ,010606 plant biology & botany - Abstract
WOS: 000456314600012, In the frame of the present paper the enzymatic transformation of apigenin-glucosides into free aglycone was achieved by autofermentation of chamomile ligulate flowers (CLF). Antioxidant properties of the autofermented CLF (A-CLF) extract were evaluated by their radical scavenging activity against hydroxyl radicals and inhibition of lipid peroxidation. Obtained results showed that A-CLF extract in a concentration of 0.84 mg/mL was able to inhibit 50% of hydroxyl radicals, while IC50 value in the case of inhibition of lipid peroxidation was 5.21 mg/mL. Antimicrobial activity was done by measuring minimal inhibitory concentration (MIC) values for eight microbial strains. Obtained MIC values (9.75-156.25 mu g/mL) confirmed high antibacterial and antifungal activities of the extract. Cytotoxic activity was done by using three histological different cell lines: Hep2C; RD and L2OB. Obtained IC50 values for these cell lines were: 28.72; 17.31 and 10.92, respectively. Furthermore, in vitro investigation of the A-CLF ability to inhibit selected enzymes (alpha-amylase, alpha-glucosidase, tyrosinase) was done as well. Determined activities against alpha-amylase and alpha-glucosidase were 0.94 and 3.24 mmol ACAE/g, respectively. Further, measured activity against tyrosinase was 0.69 mg KAEs/g indicating high enzyme-inhibitory activity of examined sample. Results demonstrated that A-CLF extracts showed considerable pharmacological activity. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved., Ministry of Education, Science and Technological Development of the Republic of Serbia [TR31013], The present work was carried out within the projects of the Ministry of Education, Science and Technological Development of the Republic of Serbia, (Projects No. TR31013). The authors are grateful to Dr. Dusan Adamovic, Institute of Field and Vegetable Crops, Backi Petrovac, Serbia, for his support in supplying plant material.
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- 2019
95. Chemical composition and biological activity of Capparis spinosa L. from Lipari Island
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Azzurra Stefanucci, Giorgia Macedonio, Gokhan Zengin, Ettore Novellino, Adriano Mollica, Grazia Luisi, Marcello Locatelli, Selçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, and Zengin, Gökhan
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0106 biological sciences ,Capparis ,Rutin ,Flavonoid ,Decoction ,Plant Science ,01 natural sciences ,law.invention ,Palmitic acid ,chemistry.chemical_compound ,food ,law ,Natural agents ,Food science ,Essential oil ,chemistry.chemical_classification ,biology ,Drug formulations ,Capparis spinosa ,Cholinesterase ,biology.organism_classification ,food.food ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry ,Phytochemical ,Antioxidant ,010606 plant biology & botany - Abstract
WOS: 000456314600016, Several plants belonging to the genus Capparis are the focus of growing interest due to their singular nutritional and medicinal properties. In the present study, flower bud samples from C. spinosa L. (Lipari Island, Italy) were subjected to decoction, Soxhlet, and microwave extraction techniques and the individual extracts investigated to better characterize the phytochemical and antioxidant profiles of the plant. Total phenolic and flavonoid amounts, phenolic composition, radical scavenging as well as reductive and metal chelating properties were determinated by well-established chemical and analytical procedures. Furthermore, cholinesterase inhibitory effects were evaluated by Ellman's method. Fatty acid percentage and essential oil composition were also detected by GC and GC-MS techniques respectively. Rutin was found to be the major component in the studied extracts. The Soxhlet extract exhibited the strongest radical scavenging and reductive activities as compared to the other extracts, most probably due to the highest concentration of phenolics, especially rutin. The best cholinesterase inhibitory effect was observed in the microwave extract. Palmitic acid was the most abundant fatty acid in the studied oil, whereas docosane was the major volatile compound in the essential oil. Present data corroborate the multipurpose potential of C. spinosa for designing bio-based drug formulations or functional applications. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.
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- 2019
96. New pharmacological targets of three Asphodeline species using in vitro and ex vivo models of inflammation and oxidative stress
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Claudio Ferrante, Annalisa Chiavaroli, Luigi Menghini, Lidia Leporini, Sheila Leone, Marcello Locatelli, Muhammad Zakariyyah Aumeeruddy, Luigi Brunetti, Gokhan Zengin, Lucia Recinella, Giustino Orlando, Mohamad Fawzi Mahomoodally, Selçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, and Zengin, Gokhan
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Lipopolysaccharide ,Health, Toxicology and Mutagenesis ,Inflammation ,010501 environmental sciences ,Pharmacology ,medicine.disease_cause ,01 natural sciences ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Lactate dehydrogenase ,medicine ,oxidative stress ,030212 general & internal medicine ,Asphodeline ,pharmaceutical applications ,0105 earth and related environmental sciences ,biology ,Chemistry ,Public Health, Environmental and Occupational Health ,Interleukin ,General Medicine ,biology.organism_classification ,Pollution ,inflammation ,Tumor necrosis factor alpha ,medicine.symptom ,natural agents ,Ex vivo ,Oxidative stress - Abstract
WOS: 000477781000004, PubMed: 30514101, This study explored the efficacy of the methanolic extract of three Asphodeline species (A. damascena subsp. rugosa, A. tenuior subsp. tenuiflora var. tenuiflora, and A. cilicica) to protect against hydrogen peroxide (H2O2)-induced lactate dehydrogenase (LDH) activity in HCT116 cells, and also any protective effects against lipopolysaccharides (LPS)-induced nitrite levels, prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2 alpha (8-iso-PGF2 alpha) levels, 5HIAA/5-HT ratio, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 gene expression in rat colon specimens. Interestingly, A. tenuior extract was most effective in improving the tested biomarkers, by reducing LDH activity and nitrite level. On the other hand, A. damascena was the only species able to blunt LPS-induced TNF-alpha gene expression in rat colon specimens. The present findings highlighted the protective effects of Asphodeline extracts via in vitro and ex vivo models of inflammation and oxidative stress, adding new insights to the pharmacological actions of these medicinal plant species.
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- 2018
97. Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management
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Hao Chang, Gagan Chhabra, Arth Patel, Nihal Ahmad, and Chandra K. Singh
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0301 basic medicine ,Male ,metallothioneins ,Phytochemicals ,chemistry.chemical_element ,Zinc ,Review ,Resveratrol ,zinc transporters ,03 medical and health sciences ,chemistry.chemical_compound ,Prostate cancer ,0302 clinical medicine ,Prostate ,medicine ,Homeostasis ,Humans ,TX341-641 ,Transcription factor ,prostate malignancy ,Nutrition and Dietetics ,Nutrition. Foods and food supply ,Prostatic Neoplasms ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,030220 oncology & carcinogenesis ,Bioaccumulation ,Curcumin ,Cancer research ,Quercetin ,natural agents ,Food Science - Abstract
Studies have suggested an important role of the trace element zinc (Zn) in prostate biology and functions. Zn has been shown to exist in very high concentrations in the healthy prostate and is important for several prostatic functions. In prostate cancer (PCa), Zn levels are significantly decreased and inversely correlated with disease progression. Ideally, restoration of adequate Zn levels in premalignant/malignant prostate cells could abort prostate malignancy. However, studies have shown that Zn supplementation is not an efficient way to significantly increase Zn concentrations in PCa. Based on a limited number of investigations, the reason for the lower levels of Zn in PCa is believed to be the dysregulation of Zn transporters (especially ZIP and ZnT family of proteins), metallothioneins (for storing and releasing Zn), and their regulators (e.g., Zn finger transcription factor RREB1). Interestingly, the level of Zn in cells has been shown to be modulated by naturally occurring dietary phytochemicals. In this review, we discussed the effect of selected phytochemicals (quercetin, resveratrol, epigallocatechin-3-gallate and curcumin) on Zn functioning and proposes that Zn in combination with specific dietary phytochemicals may lead to enhanced Zn bioaccumulation in the prostate, and therefore, may inhibit PCa.
- Published
- 2021
98. Editorial: Regulation of PI3K/Akt signaling pathway: A feasible approach for natural neuroprotective agents to treat various neuron injury-related diseases.
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Chen Y, Hsu C, Chen X, Zhang H, and Peng W
- Abstract
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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- 2023
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99. Emerging Strategies to Combat Methicillin-resistant Staphylococcus aureus (MRSA): Natural Agents with High Potential.
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Ueda JM, Milho C, A Heleno S, Soria-Lopez A, Carpena M, Alves MJ, Pires T, Prieto MA, Simal-Gandara J, C Calhelha R, Ferreira ICFR, and Barros L
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- Humans, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Methicillin, Penicillins, Microbial Sensitivity Tests, Methicillin-Resistant Staphylococcus aureus, Staphylococcal Infections drug therapy, Staphylococcal Infections microbiology
- Abstract
Infectious diseases have always been a concern for human health, responsible for numerous pandemics throughout history. Even with the advancement of medicine, new infectious diseases have been discovered over the years, requiring constant effort in medical research to avoid future problems. Like the emergence of new diseases, the increase in resistance of certain bacterial strains also becomes a concern, carried out through the misuse of antibiotics, generating the adaptation of certain microorganisms. Worldwide, the resistance developed by several bacterial strains is growing exponentially, creating awareness and developing novel strategies to control their evolution a mandatory research topic. Methicillin-resistant Staphylococcus aureus (MRSA) is an example of a bacterial strain that causes serious and mortal infections. The fact is that this bacterial strain started to develop resistance against commonly used antibiotics, first to penicillin and against methicillin. Thus, the treatment against infections caused by MRSA is limited and difficult due to its capacity to develop defense mechanisms against the antibiotic's action. Given the urgency to find new alternatives, the scientific community has been developing interesting research regarding the exploitation of natural resources to discover bioactive molecules that are able to inhibit/kill MRSA. In this sense, several natural matrices, namely plants, have shown great potential against MRSA, due to the presence of phenolic compounds, molecules with high antimicrobial capacity due to their chemical structure and arrangement., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
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- 2023
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100. Diseño de sistemas basados en materiales porosos para la liberación controlada de agentes naturales contra plagas
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Palomares Gimeno, Antonio Eduardo, Jorda Moret, Jose Luis, Universitat Politècnica de València. Departamento de Ingeniería Química y Nuclear - Departament d'Enginyeria Química i Nuclear, Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials, Arroyo Fructuoso, Alba, Palomares Gimeno, Antonio Eduardo, Jorda Moret, Jose Luis, Universitat Politècnica de València. Departamento de Ingeniería Química y Nuclear - Departament d'Enginyeria Química i Nuclear, Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials, and Arroyo Fructuoso, Alba
- Abstract
[ES] La aplicación de productos químicos sintéticos para el control de plagas genera importantes problemas medioambientales y hace que sea necesario el estudio de nuevos sistemas más sostenibles y ecológicos. Una alternativa es el uso de agentes naturales derivado de aceites esenciales, los cuales tienen actividad biocida sobre algunas plagas y no generan problemas en el medio ambiente. El problema de estos agentes naturales es su elevada volatilidad, por ello es necesario, para su aplicación, soportarlos sobre materiales que permitan una liberación controlada y prolongada del agente natural a lo largo del tiempo. En este TFG se han seleccionado el citronelol, el citronelal y el geraniol, todos ellos compuestos presentes en el aceite de citronela, como agentes naturales con actividad biocida que pueden ser utilizados para el control de plagas. Se han utilizado como soportes distintos tipos de materiales porosos: MCM41 y MCM-41 sililado, ambos sintetizados en el laboratorio, carbón activo (Norit 100 MESH), sepiolita y tierra de diatomeas (Celite®545). Se han incorporado a estos materiales los agentes naturales seleccionados y se ha estudiado su liberación durante un periodo de tres meses. Los resultados permiten establecer cuáles serían los sistemas más adecuados según su aplicación agrícola. Así, se ha determinado que, si se quiere utilizar para el control de plagas, previniendo la aparición de estas, lo más adecuado sería utilizar los agentes naturales citronelol y geraniol con el material soporte MCM-41 sililado pues produce una liberación más lenta y continuada en el tiempo. Por contrario, si se quiere aplicar como tratamiento de choque sobre una plaga ya instalada se necesita sistemas con cantidades de liberación más elevadas. Para este último caso lo más adecuado sería utilizar los agentes naturales citronelol y geraniol con el material soporte sepiolita, pues se produce una liberación más rápida, proporcionando concentraciones mayores., [EN] The application of synthetic chemicals for pest control generates significant environmental problems and makes the study of new, more sustainable and ecological systems necessary. An alternative is the use of natural agents derived from essential oils, which have biocidal activity on some pests and do not cause problems in the environment. The problem of these natural agents is their high volatility, so it is necessary, for their application, to support them on materials that allow a controlled and prolonged release of the natural agent over time. In this TFG, citronellol, citronelal and geraniol have been selected, all of them compounds present in citronella oil, as natural agents with biocidal activity that can be used for pest control. Different types of porous materials have been used as supports: MCM-41 and MCM-41 silylated, both synthesized in the laboratory, active carbon (Norit 100 MESH), sepiolite and diatomites (Celite®545). The selected natural agents have been incorporated into these materials and their release has been studied over a period of three months. The results allow to establish which would be the most appropriate systems according to their agricultural application. Thus, it has been determined that, if it is to be used for pest control, preventing the appearance of these, the most appropriate would be to use the natural agents citronellol and geraniol with the silylated MCM-41 support material as it produces a slower and more continuous release in the time. On the contrary, if you want to apply as shock treatment on an already installed pest, systems with higher release amounts are needed. In the latter case, the most appropriate would be to use the natural agents citronellol and geraniol with the sepiolite support material, as a faster release occurs, providing higher concentrations., [CA] L'aplicació de productes químics sintètics per al control de plagues genera importants problemes mediambientals i fa que siga necessari l'estudi de nous sistemes més sostenibles i ecològics. Una alternativa és l'ús d'agents naturals derivat d'olis essencials, els quals tenen activitat biocida sobre algunes plagues i no generen problemes en el medi ambient. El problema d'aquests agents naturals és la seua elevada volatilitat, per això és necessari, per a la seua aplicació, suportar-los sobre materials que permeten un alliberament controlat i prolongat de l'agent natural al llarg del temps. En aquest TFG s'han seleccionat el citronelol, el citronelal i el geraniol, tots ells compostos presents en l'oli de citronel·la, com a agents naturals amb activitat biocida que poden ser utilitzats per al control de plagues. S'han utilitzat com a suports diferents tipus de materials porosos: MCM-41 i MCM-41 sililat, tots dos sintetitzats en el laboratori, carbó actiu (Norit 100 MESH), sepiolita i terra de diatomees (Celite®545). S'han incorporat a aquests materials els agents naturals seleccionats i s'ha estudiat el seu alliberament durant un període de tres mesos. Els resultats permeten establir quins serien els sistemes més adequats segons la seua aplicació agrícola. Així, s'ha determinat que, si es vol utilitzar per al control de plagues, prevenint l'aparició d'aquestes, el més adequat seria utilitzar els agents naturals citronelol i geraniol amb el material suport MCM-41 sililat perquè produeix un alliberament més lent i continuada en el temps. Per contrari, si es vol aplicar com a tractament de xoc sobre una plaga ja instal·lada es necessita sistemes amb quantitats d'alliberament més elevades. Per a aquest últim cas el més adequat seria utilitzar els agents naturals citronelol i geraniol amb el material suport sepiolita, perquè es produeix un alliberament més ràpid, proporcionant concentracions majors.
- Published
- 2020
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