51. Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity
- Author
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Gordon A. Ferns, Mahmoud Ebrahimi, Syyed Javad Hosseininezhad, Shima Tavallaei, Seyyed Mohamad Reza Parizade, Mohamad Taghi Shakeri, Mina Akbari Rad, Majid Ghayour-Mobarhan, Seyyed Mohammad Reza Kazemi-Bajestani, Maryam Hoseini, Mohsen Azimi-Nezhad, Fatemeh Farhoudi, Naser Mobarra, Samaneh Rezaiean, and Amirhosein Vejdani
- Subjects
Adult ,Male ,medicine.medical_specialty ,Docosahexaenoic Acids ,HSP27 Heat-Shock Proteins ,Blood Pressure ,Autoimmune Diseases ,Body Mass Index ,chemistry.chemical_compound ,Fish Oils ,Risk Factors ,Internal medicine ,Fatty Acids, Omega-3 ,Weight Loss ,medicine ,Humans ,Omega 3 fatty acid ,Aged ,chemistry.chemical_classification ,Inflammation ,Metabolic Syndrome ,medicine.diagnostic_test ,Cholesterol ,business.industry ,R735 ,Fatty acid ,General Medicine ,Middle Aged ,Fish oil ,medicine.disease ,Eicosapentaenoic acid ,Endocrinology ,C-Reactive Protein ,chemistry ,Eicosapentaenoic Acid ,Docosahexaenoic acid ,Cardiovascular Diseases ,Dietary Supplements ,Female ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,business ,Lipid profile ,Biomarkers - Abstract
OBJECTIVE\ud \ud Fish-oil contains high concentrations of omega-3 fatty acids that have been shown to have anti-inflammatory properties. We have evaluated the effects of purified omega-3 fatty acid supplements on several anthropometric and biochemical parameters, including heat shock protein (Hsp) 27 antibody titres in subjects with metabolic syndrome.\ud \ud METHODS\ud \ud Subjects (n = 120) with metabolic syndrome (mean age of 52.9 +/- 11.9 years) were randomly allocated to one of two groups: sixty subjects were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period.\ud \ud RESULTS\ud \ud The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega 3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group.\ud \ud CONCLUSION\ud \ud It appears that omega 3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity