51. Emergence of Magnusiomyces capitatus infections in Western Nepal.
- Author
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Subramanya Supram H, Gokhale S, Chakrabarti A, Rudramurthy SM, Gupta S, and Honnavar P
- Subjects
- Adolescent, Aged, Aged, 80 and over, Amplified Fragment Length Polymorphism Analysis, Antifungal Agents pharmacology, Cluster Analysis, DNA, Fungal chemistry, DNA, Fungal genetics, DNA, Ribosomal chemistry, DNA, Ribosomal genetics, DNA, Ribosomal Spacer chemistry, DNA, Ribosomal Spacer genetics, Female, Humans, Immunocompromised Host, Male, Microbial Sensitivity Tests, Middle Aged, Molecular Sequence Data, Molecular Typing, Mycological Typing Techniques, Nepal epidemiology, Phylogeny, RNA, Ribosomal genetics, Saccharomycetales genetics, Saccharomycetales physiology, Sequence Analysis, DNA, Tertiary Care Centers, Mycoses epidemiology, Mycoses microbiology, Saccharomycetales classification, Saccharomycetales isolation & purification
- Abstract
Magnusiomyces capitatus is an emerging opportunistic yeast in the Mediterranean region. We report from Nepal one case of M. capitatus infection and six other cases of colonization/probable infection due to M. capitatus at a tertiary care center. Majority of the patients were immunocompromised, at extreme age, associated with comorbidities, and had history of close contact with livestock and poultry. The isolates were identified by phenotypic and genotypic (ITS and D1/D2 region of 26S rDNA sequence) methods. Molecular typing of the isolates was carried out by amplified fragment length polymorphism. Minimum inhibitory concentration (MIC) of the isolates for amphotericin B, caspofungin, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, and micafungin were 2, 0.1-4, 2, 0.12-0.5, 0.12-0.5, 0.25, 1-4, and 1-4 μg/ml, respectively. Presence of M. capitatus infection was not known in Nepal, and the study should alert the clinicians and infectious disease specialists., (© The Author 2015. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2016
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