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59 results on '"hemostatic factors"'

51. The influence of physiological and surgical menopause on coronary heart disease risk markers

Author

Peter Kenemans, Marieke O. Verhoeven, Rene H. M. Verheijen, Marius J. van der Mooren, Tom Teerlink, Peter G. Scheffer, Obstetrics and gynaecology, Clinical chemistry, ICaR - Ischemia and repair, and University of Groningen

Subjects
Leptin, Asymmetric dimethylarginine, ASYMMETRICAL DIMETHYLARGININE, Heart disease, Homocysteine, Ubiquinone, medicine.medical_treatment, POPULATION-BASED COHORT, Coronary Disease, Body Mass Index, chemistry.chemical_compound, Risk Factors, Longitudinal Studies, Cardiovascular risk factors, Estradiol, Obstetrics and Gynecology, Hormone replacement therapy (menopause), HEALTHY POSTMENOPAUSAL WOMEN, Middle Aged, Lipids, Menopause, C-Reactive Protein, CARDIOVASCULAR-DISEASE, Symmetric dimethylarginine, Female, Preventive bilateral salpingo-ovariectomy, medicine.medical_specialty, AUSTRALIAN-BORN WOMEN, Ovariectomy, Arginine, COENZYME Q(10), Surgical Menopause, Internal medicine, medicine, Humans, Inhibins, business.industry, HORMONE REPLACEMENT THERAPY, medicine.disease, Endocrinology, chemistry, PLASMA HOMOCYSTEINE, Case-Control Studies, HEMOSTATIC FACTORS, Follicle Stimulating Hormone, business, Body mass index, Biomarkers
Abstract

Objective: To investigate the influence of physiological and surgical menopause oil Serum concentrations of corollary heart disease (CHD) risk markers and sex hormones. Design: Physiological menopausal transition was investigated in two studies. In a longitudinal Study, 16 women were followed from 2 years before until 2 years after physiological menopause. In a case-control study, 27 early postmenopausal women were compared with 27 age-matched late premenopausal women. Surgical menopause was investigated in 11 women undergoing a prophylactic bilateral salpingo-oophorectomy. The following parameters were measured: serum concentrations of estradiol, follicle-stimulating hormone, inhibin A, inhibin B, asymmetric dimethylarginine, lipids, leptin, homocysteine, C-reactive protein, and coenzyme Q10, as well as weight and body mass index. Results: After physiological and surgical menopause, serum estradiol and inhibin A and B decreased, whereas follicle-stimulating hormone increased (all P values

Published
2009
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52. NASH predicts plasma inflammatory biomarkers independently of visceral fat in men

Author

Giovanni Targher, Giacomo Zoppini, Lorenzo Bertolini, Massimo Franchini, Giuseppe Lippi, Michele Muggeo, Christopher P. Day, and Stefano Rodella

Subjects
Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Overweight, Intra-Abdominal Fat, Fibrinogen, Endocrinology, Insulin resistance, nash, Predictive Value of Tests, Risk Factors, Internal medicine, Plasminogen Activator Inhibitor 1, medicine, Humans, Obesity, inflammatory biomarkers, hemostatic factors, Triglycerides, Inflammation, Nutrition and Dietetics, Adiponectin, business.industry, Confounding, Case-control study, nutritional and metabolic diseases, Middle Aged, medicine.disease, digestive system diseases, Fatty Liver, C-Reactive Protein, Cardiovascular Diseases, Predictive value of tests, Case-Control Studies, Linear Models, Steatosis, medicine.symptom, Insulin Resistance, business, Biomarkers, medicine.drug
Abstract

We assessed the differential contribution of nonalcoholic steatohepatitis (NASH) and visceral adiposity to nontraditional cardiovascular risk biomarkers in adult men. We enrolled 45 consecutive, overweight, male patients with biopsy-proven NASH, 45 overweight male patients without ultrasound-diagnosed hepatic steatosis, and 45 healthy male volunteers. All participants were matched for age; NASH and overweight patients were also matched for BMI and visceral adiposity (as estimated by abdominal ultrasonography). Nontraditional cardiovascular risk biomarkers were measured in all participants. Plasma concentrations of high-sensitivity C-reactive protein (hs-CRP), fibrinogen, plasminogen activator inhibitor-1 (PAI-1) activity, and adiponectin were markedly different among the groups; the lowest values (the highest for adiponectin) were in nonobese healthy subjects, intermediate in overweight nonsteatotic patients, and the highest (the lowest for adiponectin) in those with biopsy-proven NASH. The marked differences in these cardiovascular risk biomarkers that were observed between overweight and NASH patients were only slightly weakened after adjustment for age, BMI, smoking, plasma triglycerides, and insulin resistance (IR) as assessed by homeostasis model assessment (HOMA). In multivariate regression analysis, NASH and visceral adiposity predicted cardiovascular risk biomarkers independently of potential confounders. In conclusion, our results suggest that NASH can predict a more atherogenic risk profile in a manner that is partly independent from the contribution of visceral adiposity in adult men.

Published
2008

53. Nonalcoholic fatty liver disease as a contributor to hypercoagulation and thrombophilia in the metabolic syndrome

Author

Targher, G., Chonchol, M., Miele, Luca, Zoppini, G., Pichiri, I., Muggeo, M., Miele L. (ORCID:0000-0003-3464-0068), Targher, G., Chonchol, M., Miele, Luca, Zoppini, G., Pichiri, I., Muggeo, M., and Miele L. (ORCID:0000-0003-3464-0068)

Abstract

Nonalcoholic fatty liver disease (NAFLD), comprising its whole spectrum of conditions ranging from simple steatosis to steatohepatitis (nonalcoholic steatohepatitis; NASH) and cirrhosis, is the most frequent liver disease in developed countries and is now regarded as the liver manifestation of the metabolic syndrome. Several studies indicate that NAFLD, especially in its necro-inflammatory form (NASH), is associated with a systemic proinflammatory/prothrombotic state, independently of shared metabolic risk factors. This suggests that NAFLD/NASH is not simply a marker of the proinflammatory/ prothrombotic state in the metabolic syndrome but is actively involved in its pathogenesis, possibly through the systemic release of proinflammatory and procoagulant factors from the steatotic liver (C-reactive protein, plasminogen activator inhibitor-1, interleukin-6, fibrinogen, and other proinflammatory cytokines). The clinical impact of NAFLD on the proinflammatory/prothrombotic risk profile deserves particular attention in view of the implications for screening and surveillance strategies in the growing number of patients with NAFLD. Copyright © 2009 by Thieme Medical Publishers, Inc.

Published
2009

54. Mechanisms coupling thrombin to metastasis and tumorigenesis.

Author

Remiker AS and Palumbo JS

Subjects
Humans, Thrombin pharmacology, Carcinogenesis immunology, Neoplasm Metastasis immunology, Thrombin therapeutic use
Abstract

The association of malignancy and thrombophilia is bidirectional, as evidenced by four decades of studies in animal models showing that hemostatic system components support cancer progression. Consistent with this view, clinical studies have suggested that anticoagulants not only limit thromboembolic complications associated with cancer, but also improve survival by impeding cancer progression, and may even prevent the development of cancer. In order to fully capitalize on this association, a detailed understanding of the mechanisms coupling hemostatic factors to cancer pathogenesis is required. Multiple studies have shown that thrombin-mediated procoagulant functions strongly promote metastatic potential. In particular, the platelet/fibrin(ogen) axis has been shown to protect newly formed micrometastases from innate immune surveillance, contribute to creation of a metastatic niche by recruitment of prometastatic inflammatory cells, and promote the epithelial to mesenchymal transition of metastatic cells. Thrombin-mediated functions have also been shown to support tumor growth in some contexts, and have even been linked to tumorigenesis in the setting of inflammation-driven colon cancer. Here, local thrombin-mediated extravascular fibrin deposition, and specifically fibrin-α M β 2 integrin interaction, push intestinal inflammatory cells toward a pro-tumorigenic phenotype, resulting in the elaboration of key cytokines and growth factors that support the proliferation and survival of transformed intestinal epithelial cells. These studies reveal that hemostatic factors can serve as a bridge between pathological inflammation and the development of cancer. As a large proportion of cancers are caused by pathological inflammation, these studies suggest that therapies targeting the nexus between hemostasis and inflammation could be used to prevent cancer development., (Copyright © 2017. Published by Elsevier Ltd.)

Published
2018
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55. Effect of an increased intake of alpha-linolenic acid and group nutritional education on cardiovascular risk factors: the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study

Author

Bemelmans, W.J., Broer, J., Feskens, E.J., Smit, A.J., Muskiet, F.A., Lefrandt, J.D., Bom, V.J., May, J.F., Meyboom-de Jong, B., Science in Healthy Ageing & healthcaRE (SHARE), Analytical Biochemistry, Lifestyle Medicine (LM), Groningen Kidney Center (GKC), and Vascular Ageing Programme (VAP)

Subjects
linoleic acid, cardiovascular risk factors, POLYUNSATURATED FATTY-ACIDS, ACUTE MYOCARDIAL-INFARCTION, nutritional education, MARGARIN study, PLASMA-CHOLESTEROL, HEALTHY-SUBJECTS, CORONARY HEART-DISEASE, ischemic heart disease, N-3, alpha-linolenic acid, CONTROLLED TRIAL, prevention, FISH, PLATELET-AGGREGATION, HEMOSTATIC FACTORS, Netherlands
Abstract

Background: The effect of long-term increased intakes of alpha-linolenic acid (ALA; 18:3n-3) on cardiovascular risk factors is unknown. Objectives: Our objectives were to assess the effect of increased ALA intakes on cardiovascular risk factors and the estimated risk of ischemic heart disease (IHD) at 2 y and the effect of nutritional education on dietary habits. Design: Subjects with multiple cardiovascular risk factors (124 men and 158 women) were randomly assigned in a double-blind fashion to consume a margarine rich in either ALA [46% linoleic acid (LA; 18:2n-6) and 15% ALA; n = 114] or LA (58% LA and 0.3% ALA; n = 168). An intervention group (n = 110; 50% ALA) obtained group nutritional education, and a control group (n = 172; 34% ALA) received a posted leaflet containing the standard Dutch dietary guidelines. Results: Average ALA intakes were 6.3 and 1.0 g/d in the ALA and LA groups, respectively. After 2 y, the ALA group had a higher ratio of total to HDL cholesterol (+0.34; 95% CI: 0.12, 0.56), lower HDL cholesterol (-0.05 mmol/L; -0.10, 0), higher serum triacylglycerol (+0.24 mmol/L; 0.02, 0.46), and lower plasma fibrinogen (-0.18 g/L; -0.31, -0.04; after 1 y) than did the LA a cup (adjusted for baseline values, sex, and lipid-lowering drugs). No significant difference existed in 10-y estimated IHD risk. After 2 y, the intervention group had lower saturated fat intakes and higher fish intakes than did the control group. Conclusions: Increased ALA intakes decrease the estimated IHD risk to an extent similar to that found with increased LA intakes. Group nutritional education can effectively increase fish intake.

Published
2002

56. Genetic Epidemiologic Studies Of Plasma Fatty Acids, Hemostatic Factors, And Abdominal Aortic Aneurysm

Author

Weng, Lu-Chen

Subjects
abdominal aortic aneurysm, gene by gender interaction, genetic association study, hemostatic factors, Mendelian randomization, Plasma fatty acids
Abstract

Plasma fatty acids and hemostatic factors are biochemical measurements and associated with the risk of venous thromboembolism (VTE) or abdominal aortic aneurysm (AAA), which are important public health issues. Current research has identified genes and variants for these diseases but they only explain a small amount of disease risk. We used three approaches to evaluate the genetic influences on these diseases or their biochemical measurements and the interactions between genetic variants and gender. In the first manuscript, we tested gene-by-gender interactions on plasma phospholipid polyunsaturated fatty acid (PUFA) levels in 8,962 individuals of European ancestry (EA) from 5 cohorts, using meta-analysis data for selected plasma PUFA-related single nucleotide polymorphisms (SNPs). A few nominally significant interactions with gender were observed (p

Published
2015

57. Hemostatic and fibrinolytic factors vary during menstrual cycle in young women.

Abstract

Studies the variation in hemostatic and fibrinolytic factors during the menstrual cycle in young women. Measurement of endogenous hormones and hemostatic factors; Variability in estradiol and progesterone during the follicular and luteal phases; Difference in the measurement of plasminogen activator inhibitor and D-dimer during the two phases.

Published
2005

58. Association of electrocardiographic left ventricular hypertrophy with incident cardiovascular disease in Japanese older hypertensive patients.

Author

Edison ES, Yano Y, Hoshide S, and Kario K

Subjects
Age Factors, Aged, Aged, 80 and over, Biomarkers blood, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Chi-Square Distribution, Fibrinogen metabolism, Humans, Hypertension blood, Hypertension diagnosis, Hypertension physiopathology, Hypertrophy, Left Ventricular blood, Hypertrophy, Left Ventricular physiopathology, Incidence, Japan epidemiology, Kaplan-Meier Estimate, Male, Middle Aged, Norepinephrine blood, Predictive Value of Tests, Proportional Hazards Models, Prospective Studies, Risk Factors, Sex Factors, Asian People, Electrocardiography, Hypertension ethnology, Hypertrophy, Left Ventricular diagnosis, Hypertrophy, Left Ventricular ethnology
Abstract

Background: Our aim was to assess whether electrocardiographic left ventricular hypertrophy (ECG-LVH) is associated with a higher risk of cardiovascular disease (CVD) events, independent of 24-hour blood pressure (BP) and circulating levels of norepinephrine and hemostatic factors., Methods: In 514 older hypertensive patients (mean age 72.3 years; 37% men), we assessed ambulatory BP values, circulating levels of norepinephrine and hemostatic factors (plasma fibrinogen, prothrombin fragment 1+2 (F1+2), von Willebrand factor (vWF), and plasminogen activator inhibitor-1 (PAI-1)), and the presence or absence of ECG-LVH (Sokolow-Lyon voltage ≥ 3.5 mV). The incidence of CVD events (i.e., myocardial infarction and stroke) was prospectively ascertained., Results: During an average 41 months of follow-up (1,751 person-years), 43 stroke and 3 myocardial infarction events occurred. At baseline, patients with ECG-LVH had higher mean 24-hour BP (148.8/83.8mm Hg vs. 135.7/77.2mm Hg) and circulating norepinephrine levels (404.6 pg/ml vs. 336.3 pg/ml) compared to those without ECG-LVH; the differences remained unchanged after adjustment for age, gender, smoking status, presence of diabetes, and antihypertensive medication uses at follow-up time (all P < 0.01). Cox proportional hazards models suggested that the hazard ratio (HR; 95% confidence interval (CI)) of CVD events for those with ECG-LVH was 4.4 (2.3-8.2), and the association between ECG-LVH and incident CVD events remained significant after adjustment for high 24-hour BP (≥130/80mm Hg), nocturnal SBP, circulating norepinephrine and fibrinogen levels (HRs, 3.5-4.2, all P < 0.001)., Conclusions: In older hypertensive patients, ECG-LVH was associated with a higher risk of CVD events, independent of ambulatory BP parameters and circulating norepinephrine and fibrinogen levels., (© American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Published
2015
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