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This article develops the concept of brokerage to analyse the systems of borderland governance that have underpinned processes of state formation and capitalist development in the conflict-affected Myanmar-China borderland region of northern Shan State since the late 1980s. It focuses on the brokerage arrangements that have developed between the Myanmar Army and local militias, and how the illegal drug trade has become integral to these systems of brokered rule. This article draws particular attention to the inherent tensions and contradictions surrounding brokerage. In the short term, deploying militias as borderland brokers has provided an expedient mechanism through which the Myanmar Army has sought to extend and embed state authority, and has also provided the stability and coercive muscle needed to attract capital, expand trade, and intensify resource extraction. However, at the same time, militias have sought to use their position as brokers to aggrandise their own power and counter the extension of central state control. In the longer term, brokerage arrangements have thus had the effect of reinvigorating systems of strongman borderland governance, further fragmenting the means of violence and the proliferation of drugs and disempowering non-militarised forms of political negotiation. [ABSTRACT FROM AUTHOR]

The article discusses a study on the challenges faced by doctors working in COVID-19 units during the second phase of the pandemic in the Czech Republic. Conducted by researchers including Anasuya Guha and published in the "Central European Journal of Public Health." The study highlights issues such as procedural challenges, COVID-19 infections among medical professionals, staff reductions impacting patient care, and the need for better support systems.

Outer space holds a special place in the geographical imagination of techno-utopianism. At a time of climate crisis, the mining of celestial bodies, including asteroids, is cast as a possible "tech-driven" response to the need for "green transition" mineral resources in a context of rising geopolitical tensions and concerns over terrestrial extraction. Although still a long way from commercial-scale implementation, outer space mining no longer appears as far-fetched science fiction within the context of a booming "New Space" industry and privatization of celestial commons. Drawing from a growing body of research and critiques of responsible mineral sourcing, we explore some of the legal, political, ethical, and environmental dimensions of outer space mining, and compare them with land-based and deep-sea terrestrial mining. We then point to key areas for further geographical and social sciences enquiries into outer space extractive frontiers, including the uneven distribution of space mining wealth, the impacts on terrestrial mining communities in the Global South, and the reconceptualization of the mining enclave. [ABSTRACT FROM AUTHOR]

Research has shown that neoadjuvant immunotherapy may provide more significant clinical benefits to cancer patients undergoing surgery than adjuvant therapy. This study examines the development of neoadjuvant immunotherapy research using bibliometric analysis. As of 12 February 2023, articles on neoadjuvant immunotherapy in the Web of Science Core Collection were collected. Coauthorship and keyword co-occurrence analyses and visualizations were performed using VOSviewer, while CiteSpace was used to identify bursting keywords and references. The study analyzed a total of 1222 neoadjuvant immunotherapy publications. The top contributors to this field were the United States, China, and Italy, and the journal with the most publications was Frontiers in Oncology. Francesco Montorsi had the highest H-index. The most common keywords were 'immunotherapy' and 'neoadjuvant therapy'. The study conducted a bibliometric analysis of over 20 years of neoadjuvant immunotherapy research, identifying the countries, institutions, authors, journals, and publications involved in this field. The findings provide a comprehensive overview of neoadjuvant immunotherapy research. [ABSTRACT FROM AUTHOR]

Green building (GB) projects, although being developed and operated for more than two decades, may still be regarded as innovative. To address the socio-environmental challenges of the built environment, GBs need to continuously innovate. A comprehensive account of the innovation frontiers and factors affecting GB project innovation is missing in previous studies. In this study, for an in-depth understanding of what makes these projects innovative and how to create an enabling environment for their innovation, semi-structured interviews with 45 GB experts from six regions were conducted. Innovation in GBs was found to be a function of the GB idea, constituent building technologies, potential performance, and the project development process. Key frontiers where innovation in GB projects is needed include environmental performance, health and well-being, and the resolution of mutually contradicting project aspirations. The study also identified some factors contributing to innovation in GBs, which are primarily related to support from the government, client, and project team; availability of time and budget; scalability of innovative solutions; and nature of the construction industry. A nexus between green certifications, sustainability, and innovation is also explained. The awareness and understanding of industry experts regarding GB project innovation will add to the theory of GB projects and green innovation, and will help stakeholders to create a more enabling environment for innovation. [ABSTRACT FROM AUTHOR]

Objective/context: This article shows the internal dynamics of a distinct frontier region along the eastern plains of the New Kingdom of Granada during the sixteenth and seventeenth centuries. The foundation of cities, the creation of governorships, their constant shifts and jurisdictional disputes, the exploitation of indigenous labor, security, and the imperial expansion were highly complex issues that today allow analyzing the territorialization of the Spanish Empire on a local scale in which multiple negotiations took place between the central power of the Audiencia at the Reign’s capital and the rulers and settlers in the frontier. Methodology: By comparing and contrasting rarely explored sources, such as the capitulations of governorships and the reports of royal officials and Jesuit missionaries on indigenous slavery and settlement, the article shows how the plain’s provinces were politically and administratively constructed over this period. Originality: the research delves into the complexities of provincial formation in a frontier area, expanding in detail the procedures for the settlement of the Llanos’ governorships, a topic little studied in the literature dedicated to the imperial past in the New Kingdom of Granada. Conclusions: The dynamism and mobility that occurred in the plains piedmont, influenced by phenomena such as indigenous slavery, jurisdictional instability and fear of possible invasions by foreign powers, reveal the local construction of the Empire and the relationships between different managing levels.

Conquest of new frontiers in the universe requires the colonization of old ones. This article interrogates technoscience desires to explore outer space, and how time and territory for discovering extraterrestrials and habitable planets are organized through settler colonialism on our own. Examining modern astronomy at Mauna Kea, I argue the technoscientific promise of the Thirty Meter Telescope hinges on a temporality of lateness—late to show up and late in time—that contributes to the dehumanization, elimination, and dispossession of Kanaka Maoli, the Indigenous people of Hawai‘i. I demonstrate further that kia‘i—mountain protectors— unsettle technoscientific conquest by cruising Mauna Kea as an alternative tempo that disrupts the pace of building the observatory.

The discovery of the Higgs boson, a fundamental particle of the Standard Model, at the Large Hadron Collider (LHC) in 2012, marked a monumental milestone in the field of particle physics. Since then, extensive research has been conducted to understand the properties and interactions of the Higgs boson, particularly its couplings with other known particles. This article provides a review of the past, present, and future measurements of the Higgs boson couplings, with a focus on the most recent experimental developments. It discusses the experimental techniques and methods used to study the Higgs boson couplings, including the production and decay channels employed in various experiments. The article highlights the important relationships between the Higgs boson and other known particles, including the gauge bosons (W and Z bosons), quarks, and leptons and the Higgs boson itself, through its self-interaction. After discussing the channels used by ATLAS and CMS collaborations to measure the Higgs boson coupling to the other standard model particles, the article will present an overview of the latest results obtained at the LHC, commenting on how various measurements have evolved over time along with a better comprehension of the detectors and ever more refined analysis techniques. Future collider developments and expectation for the measurement of the Higgs boson couplings and double-Higgs boson production with increased precision and accuracy will be discussed along with the main challenges faced by future experiments.

Frontier making in Ethiopia has historical roots from the formation of the modern Ethiopian state in the late-19th century through wars of conquest. The conquest, which was inspired by political and economic motivations of the highland Christian kingdom, used the notion of a "civilizing mission"—civilizing the "backward" and "underdeveloped" people, and "underutilized" spaces—through imposition of an imperial state system and Orthodox Christianity. The foundation and horizontal expansion of Addis Ababa or Finfinne by displacing Indigenous inhabitants was part of the state building project under successive regimes. Over the last century and a half, the city has continued its unchecked expansion in a process involving multilayered actors whose interests overlapped in terms of grabbing the land they considered "underutilized." More specifically, the last three decades evince commoditization of farmlands, grazing areas, and cultural and sacred spaces through land lease, which eventually dissolve existing customary systems, values, and practices. This paper critically analyzes the dynamics of frontier making in or from Addis Ababa or Finfinne, the political economy behind such unchecked frontier expansion and how it activated the power of resistance in 2014. The paper concludes that frontier making in or from Addis Ababa through dispossession of Oromo farmers has been part of the broader political establishment in Ethiopia and should be viewed within the same lens. [ABSTRACT FROM AUTHOR]

Background: As the complexity and diversity of the tumor immune microenvironment (TIME) are becoming better understood, burgeoning research has progressed in this field. However, there is a scarcity of literature specifically focused on the bibliometric analysis of this topic. This study sought to investigate the development pattern of TIME-related research from 2006 to September 14, 2022, from a bibliometric perspective. Methods: We acquired both articles and reviews related to TIME from the Web of Science Core Collection (WoSCC) (retrieved on September 14, 2022). R package "Bibliometrix" was used to calculate the basic bibliometric features, present the collaborative conditions of countries and authors, and generate a three-field plot to show the relationships among authors, affiliations, and keywords. VOSviewer was utilized for co-authorship analysis of country and institution and keyword co-occurrence analysis. CiteSpace was used for citation burst analysis of keywords and cited references. In addition, Microsoft Office Excel 2019 was used to develop an exponential model to fit the cumulative publication numbers. Results: A total of 2545 publications on TIME were included, and the annual publication trend exhibited a significant increase over time. China and Fudan University were the most productive country and institution, with the highest number of publications of 1495 and 396, respectively. Frontiers in Oncology held the highest number of publications. A number of authors were recognized as the main contributors in this field. The clustering analysis revealed six clusters of keywords that highlighted the research hot spots in the fields of basic medical research, immunotherapy, and various cancer types separately. Conclusions: This research analyzed 16 years of TIME-related research and sketched out a basic knowledge framework that includes publications, countries, journals, authors, institutions, and keywords. The finding revealed that the current research hot spots of the TIME domain lie in "TIME and cancer prognosis", "cancer immunotherapy", and "immune checkpoint". Our researchers identified the following areas: "immune checkpoint-based immunotherapy", "precise immunotherapy" and "immunocyte pattern", which may emerge as frontiers and focal points in the upcoming years, offering valuable avenues for further exploration. [ABSTRACT FROM AUTHOR]

This paper presents the results of geophysical surveys conducted within two castles in central Iberia: the fortifications of Molina de Aragón and Atienza, both located within the modern province of Guadalajara in Spain. They represent essential case studies for understanding the transformations of the frontier societies of medieval south‐western Europe, because both were founded during the Andalusi period, both played a fundamental role at the time of the military confrontations between opposing Islamic and Christian states, and both became capitals within the feudal dependencies of the Crown of Castile during the Late Middle Ages. At present, these castles are uninhabited and protected archaeological sites, with no modern developments within their wards; the adjacent towns have developed on the outskirts of their outer walls. Although both castles have been the focus of uneven amounts of archaeological research, geophysical surveys, the first conducted at these sites, have proved to be a fundamental tool not only for planning future archaeological investigations but also for the data that they have provided on the potential roles of these castle wards. [ABSTRACT FROM AUTHOR]

The west of Santa Catarina was occupied by indigenous groups and caboclos until the arrival of other migrants and immigrants in the 20th century. The spaces occupied by fields and forests were described as "sertões" (wilderness), as they did not have a suitable agricultural practice at the time. The object of this article is to analyze the uses and occupation process of forest areas in western Santa Catarina from 1920 to 1960, when this frontier was "closed". For this, a varied typology of sources was analyzed, in dialogue with the precepts of environmental history. The advance of colonization was responsible for the reduction of spaces dominated by the forest, which is now occupied by agriculture and animal husbandry. Both were the main elements responsible for the formation and consolidation of the agro-industrial sector in the region. [ABSTRACT FROM AUTHOR]

Copyright of Confluenze. Rivista di Studi Iberoamericani is the property of Universita di Bologna, Dipartimento di Lingue, Letterature e Culture Moderne and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In the world of chaos, nothing is certain. In such an unpredictable world, measuring the efficiency of any individual is inevitable. In a conventional data envelopment analysis (DEA) model, exact input and output quantity data are needed to measure the relative efficiencies of homogeneous decision-making units (DMUs). However, in many real-world applications, the exact knowledge of data might not be available. The rough set theory allows for handling this type of situation. This paper tries to construct a rough DEA model by combining conventional DEA and rough set theory using optimistic and pessimistic $ \beta $ confidence values of rough variables, all of which help provide a way to quantify uncertainty. In the proposed method, the same set of constraints (production possibility sets) is employed to build a unified production frontier for all DMUs that can be used to properly assess each DMU's performance in the presence of rough input and output data. Besides, a ranking system is presented based on the approaches that have been proposed. In the presence of uncertain conditions, this article investigates the efficiency of the Indian fertilizer supply chain for over a decade. The results of the proposed models are compared to the existing DEA models, demonstrating how decision-makers can increase the supply chain performance of Indian fertilizer industries. [ABSTRACT FROM AUTHOR]

Using a recently re-discovered text by Alexander Chayanov, this article argues that while demographic differentiation may lead to stratification, this is, for a variety of reasons, mostly temporary and does not generally result in the formation of antagonistic rural classes. At the same time there is also the far more deep-rooted phenomenon of market-induced differentiation. This latter type stems from, and reflects, capital's ability to create and bridge price differentials, mostly through long-distance trading and food engineering. [ABSTRACT FROM AUTHOR]

Copyright of De Familias y Terapias is the property of Instituto Chileno de Terapia Familiar and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article follows the history of the Dawei special economic zone (SEZ), a port, industrial zone, and logistics project located in Myanmar's southern borderlands. Suspended in 2013 due to financing shortfalls and public criticism, the Dawei project's implementation has been far from straightforward. This article dwells on the non-linear temporality of the project, focusing on the problem of financing. It is there, above all, that project proponents continually entertain both prospects of progress and frustrating obstacles. This story of financing shows, I argue, that frontiers are temporal projects, constituted by fits and starts, slowdowns and accelerations, and periods of deferral and delay. Beginning with the project's origins and moving through recent attempts to revive it, I foreground three moments of labor in and of time – three timescapes, in short – which I describe in terms of futurity and deferral, boom and bust, and suspension and renewal. The complex temporality of the project raises doubts about the notion that capitalist modernity consists of a singular, abstract, homogeneous time – defined by acceleration, speed, or time–space compression. On this frontier, rather, the inter-mingling of multiple times suggests not vestiges of the premodern, but the heterogeneous timescapes – unstable, unruly, uneven – that compose capitalist modernity itself. [ABSTRACT FROM AUTHOR]

Objective/context: This article shows the internal dynamics of a distinct frontier region along the eastern plains of the New Kingdom of Granada during the sixteenth and seventeenth centuries. The foundation of cities, the creation of governorships, their constant shifts and jurisdictional disputes, the exploitation of indigenous labor, security, and the imperial expansion were highly complex issues that today allow analyzing the territorialization of the Spanish Empire on a local scale in which multiple negotiations took place between the central power of the Audiencia at the Reign's capital and the rulers and settlers in the frontier. Methodology: By comparing and contrasting rarely explored sources, such as the capitulations of governorships and the reports of royal officials and Jesuit missionaries on indigenous slavery and settlement, the article shows how the plain's provinces were politically and administratively constructed over this period. Originality: the research delves into the complexities of provincial formation in a frontier area, expanding in detail the procedures for the settlement of the Llanos' governorships, a topic little studied in the literature dedicated to the imperial past in the New Kingdom of Granada. Conclusions: The dynamism and mobility that occurred in the plains piedmont, influenced by phenomena such as indigenous slavery, jurisdictional instability and fear of possible invasions by foreign powers, reveal the local construction of the Empire and the relationships between different managing levels. [ABSTRACT FROM AUTHOR]

Copyright of Studia Periegetica is the property of WSB University in Poznan and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Ecological restoration projects are becoming a mainstream of research, and their studies are widely followed by scholars worldwide, yet there is no comprehensive review of this research. Nowadays, bibliometrics has attracted much attention from the scientific community, and its methodological approach allows quantitative and qualitative analysis of research performance in journals or subject areas. This paper provides a systematic and comprehensive description of the progress and hotspots of ecological restoration projects from a bibliometric perspective, based on 1173 articles in the Web of Science Core Collection (WOSCC) database. Research on ecological restoration projects has shown a positive growth trend since the twenty-first century. China and the USA are the most active countries in terms of the number of relevant articles published, and more than half of the top 10 active institutions are from China, but there is less collaboration between different countries/institutions. Research in ecological restoration projects is summarized into three main research areas: the main ecological damage problems, the impact of human beings on ecological damage, and the main methods of ecological restoration. Finally, some challenges and outlooks conducive to the rapid and balanced development of ecological restoration projects are presented, which provide valuable references and help for future researchers. [ABSTRACT FROM AUTHOR]

This paper applies David Lowenthal's 1968 Geographical Review article "The American Scene" and John Dos Passos' 1963 travelogue Brazil on the Move to develop a notion of the Brazilian scene. It argues for the importance of "scene" as a concept in geographic inquiry and the relevance of Brazil to concerns across the discipline. Scene matters to geographers because it provides immense pedagogical value in explaining the character and most important features of a place. As a demographic and socioeconomic "microcosm of the world," Brazil is fertile ground for constructing a theory of scene. Three interrelated concepts are integral to the Brazilian scene: ufanismo (pride in abundance of land and natural resources), a belief in the promise of the future, and movement inward from the Atlantic. A close reading of Brazil on the Move advances the concept of scene beyond the "long succession of idealized images and visual stereotypes" posed by Lowenthal, and toward including visions that better account for issues of contemporary interest. [ABSTRACT FROM AUTHOR]

In the months leading up to the transfer of power in India, the eastern Himalayan kingdom of Sikkim made several representations to the Cabinet Mission and other constitutional bodies that were giving shape to the successor Indian government. The Sikkim Darbar was worried that its ambiguous position under colonial treaties might lead India to treat it as one of the five-hundred odd princely states that were slowly merging with the union. In letters, memoranda, legal briefs, and personal meetings, the Darbar argued that it was racially, religiously, socially, and culturally distinct from India, and that its allegiance lied to its north with Tibet. This article traces the vocabulary for the Sikkim Darbar's assertion of difference from India back to the racialised imperial writing and realpolitik that had informed colonial policy towards the Himalayan states since the nineteenth century, most notably Olaf Caroe's 1940 thesis on the 'Mongolian Fringe'. This archival evidence emphasises Sikkimese agency and helps excavate an imagination of the Himalaya from within the region. The article also nuances the history of the forging of Indian republic by foregrounding the processes of negotiation and compromise that continued to shape the territorial contours of the Indian nation long after the moment of decolonisation. 1 [ABSTRACT FROM AUTHOR]

Objective: To summarize the general information and hotspots of functional near-infrared spectroscopy (fNIRS)-based clinical disease research over the past 10 years and provide some references for future research. Methods: The related literature published between 1 January 2011 and 31 January 2022 was retrieved from the Web of Science core database (WoS). Bibliometric visualization analysis of countries/regions, institutions, authors, journals, keywords and references were conducted by using CiteSpace 6.1.R3. Results: A total of 467 articles were included, and the annual number of articles published over nearly a decade showed an upward trend year-by-year. These articles mainly come from 39 countries/regions and 280 institutions. The representative country and institution were the USA and the University of Tubingen. We identified 266 authors, among which Andreas J Fallgatter and Ann-Christine Ehlis were the influential authors. Neuroimage was the most cocited journal. The major topics in fNIRS disease research included activation, prefrontal cortex, working memory, cortex, and functional magnetic resonance imaging (fMRI). In recent years, the Frontier topics were executive function, functional connectivity, performance, diagnosis, Alzheimer's disease, children, and adolescents. Based on the burst of co-cited references, gait research has received much attention. Conclusion: This study conducted a comprehensive, objective, and visual analysis of publications, and revealed the status of relevant studies, hot topics, and trends concerning fNIRS disease research from 2011 to 2022. It is hoped that this work would help researchers to identify new perspectives on potential collaborators, important topics, and research Frontiers. [ABSTRACT FROM AUTHOR]

This chapter shows how the speculative (pre-)lives and afterlives of resource extraction are put together through corporate narrative and imaginative practices. It shows that the expansion of extractive frontiers is not merely driven by abstract and asocial market forces, but that deeply social practices of storytelling and imagination are also vital for making mining exploration possible. Drawing on 15 months of fieldwork in Colombia, it discusses the spectacular narratives surrounding the exploration campaign of South African gold mining corporation AngloGold Ashanti (AGA) across the Colombian Andes. The chapter examines how corporate storytelling unfolds through corporate processes and individual narratives, and shows it to be integral to conjuring Colombia as the ‘last Andean frontier’ for gold exploration in the international investor’s imagination. Corporate narrative and performative practices were not only crucial to attracting and sustaining investor interest, but also served an important internal function in shaping the professional identity of exploration geologists and corporate identity more broadly. At the same time, the chapter shows that frontier expansion and the capitalisation of mineral finds are uneven and speculative processes, with room for alternative stories.

Extractive frontiers are expanding rapidly as demand for minerals and metals continues to increase, often driven by—and despite—concerns about sustainability. This introduction brings theories of the resource curse and extractivism into conversation with materiality and social reproduction to account for the multiple scales and dimensions in which extractive industries operate, taking heed of the gendered and lived experience of communities, indigenous peoples and workers. We highlight the global resonance of these diverse experiences to illuminate the making of frontiers, forms of belonging, and accumulation logics that produce, enable, and potentially undermine the expansion of extractive industries.

Background: In recent years, liquid biopsy has shown great potential for improving cancer diagnosis and treatment. This study aimed to explore the trends and prospects in liquid biopsy for cancer from a bibliometric perspective.Methods: Reviews and articles on liquid biopsy and cancer were collected from the Web of Science Core Collection (WoSCC). Key bibliometric characteristics were analyzed using CiteSpace. Co-occurrence analysis of keywords and co-citation analysis of references was performed.Results: A total of 6331 publications from 11 years of scientific research were retrieved. Ninety-five countries and 7004 institutions in liquid biopsy and cancer contributed. The United States (US) and China published the most articles. The institution with the most published articles was the University of Texas MD Anderson Cancer Center. The most published journals were Cancer and Frontiers in Oncology. “Bettegowda (2014)'' was the most cited reference with the highest burst strength in the last decade. Cluster analysis revealed that the recent hot topics were “circulating tumor cells,” “cancer,” and “exosomes.''Conclusions: This bibliometric analysis maps the basic knowledge structure of the field of liquid biopsy for cancer. The field is entering a phase of rapid development. The hot spots identified in this study deserve further investigation.

In 2018, an unprecedented red tide prompted Chile's Ministry of Health to close fisheries throughout the country's southern Aysén Region. The disaster heightened the precarity of "paper fishers," or those who seldom fish but deftly navigate Chile's neoliberal fisheries management system. Amid the crisis, these fishers performed valuable distributive labor. They connected benefits from transferable fishing quotas to community‐based networks, persuaded officials to recognize additional claimants, and redistributed cash in their communities. This enabled fishers to access public funds when fishing was impossible and strengthened community solidarity in the face of precarity. Yet it also required that claims for financial compensation be legible to state officials, and it prevented political actions that would have disrupted the state‐backed aquaculture industry, despite the latter's contribution to the red tide. Thus, neoliberal distributive programs that depend on the commodification of nature simultaneously benefit rural communities in crisis and facilitate the displacement of beneficiaries. [ABSTRACT FROM AUTHOR]

Background: Despiteproviding clinicalbenefit,immunecheckpointinhibitors (ICIs) can cause immune-related adverse events (irAEs) in anumberof patients. This study explored the development pattern in irAEs research froma bibliometric perspective. Methods: We obtained articles and reviews related to irAEs from the Web of Science Core Collection (WoSCC) (retrieved on September 13, 2022). Using the R package "Bibliometrix", the main bibliometric features were calculated, and a three-filed plot was generated to show the relationship between authors, institutions, and topics. VOSviewer was used for co-authorship and keyword co-occurrence analysis and visualization. CiteSpace was used to detect burst references and keywords. Results: A total of 3995 publications on irAEs were included. The United States (US), Japan, and China had the highest publications. The Journal for ImmunoTherapy of Cancer had the highest number of publications. In addition to "immune-related adverse events", "immune checkpoint inhibitors", "immunotherapy", and "nivolumab" were the most frequently used keywords. Conclusions: A bibliometric analysis of 17 years of irAEs research was conducted to map a basic knowledge structure including countries, institutions, authors, journals, and publications. The findings provided a comprehensive perspective on the broad future of this research area. [ABSTRACT FROM AUTHOR]

We answer the question of which conjunctive queries are uniquely characterized by polynomially many positive and negative examples and how to construct such examples efficiently. As a consequence, we obtain a new efficient exact learning algorithm for a class of conjunctive queries. At the core of our contributions lie two new polynomial-time algorithms for constructing frontiers in the homomorphism lattice of finite structures. We also discuss implications for the unique characterizability and learnability of schemamappings and of description logic concepts. [ABSTRACT FROM AUTHOR]

Across the global south, regimes of labour and mobility control are reforming that attempt to manage the northern movement of people. By combining financing development projects with explicit forms of border enforcement (including border personnel training and new securitization technologies), western governments and southern elites attempt to encourage publics (invariably poorer people of colour) to stay in local regions, rather than seek better livelihoods elsewhere. By reference to the USAID funded Centros Quédate or Stay Here Centres in Guatemala, this paper explores the merging of development and migration governance regimes through the concept of "frontiering through development." The paper argues that initiatives such as these fail to consider the root causes of colonialism and imperialism that have long led people to migrate in the first place. Moreover, migration is cast as something problematic under discourses of populist economic nationalist sentiment, rather than beneficial to migrants, country-of-origin and destination regions. However, rather than passive recipients of patronising development, I show how participants rework the Quédate programme to fit their own onward goals. Paternalist development paradigms should take into account how crucial and embedded mobile livelihoods are in present-day realities. [ABSTRACT FROM AUTHOR]

The intensifying extraction, privatization, and conservation of maritime spaces are transforming seascapes globally. Amidst rapid coastal change and the ambiguous reconfiguration of oceans as frontiers are coastal dwellers who occupy the shadows of these seascapes. In contrast to the capture of high-profile marine species, the harvest of the edible nests of balinsasayaw (swiftlet, Aerodramus fuciphagus) remains largely concealed at the interstitial spaces between land, coast, and sea. In the Philippines, harvesters known as busyador negotiate social relations, political networks, and karst systems to extract these lucrative nests. Despite the nest industry growing in value in Southeast Asia, we show how the busyador struggle in precarious social relations and spaces peripheral to coastal governance in northern Palawan Island. Building on the concept of 'seascape assemblages', we emphasize the importance of the less visible human-nonhuman relations that shape the nest harvest and trade. We trace the marginal social histories of the balinsasayaw by highlighting the precarious nature of the harvest, revealing how the busyador are subject to unfair working conditions, dispossession, and violence. We argue that as state actors and local elites reconfigure oceans as frontiers for development and conservation, struggles over labour and tenure rights, livelihood opportunities, and justice at sea are disregarded. [ABSTRACT FROM AUTHOR]

This study aims to formulate, determine alternative and priority strategies for the development of the maritime defense area of Miangas Island using qualitative and quantitative methods. Data sources consist of two types, which are primary data sources and secondary data sources. Data analysis uses evaluative methods and SWOT analysis. The results showed that the WO 1 strategy had the highest weight and was a priority strategy, such as taking advantage of the Indonesian Navy's MEF policy opportunities by increasing the Posal Miangas capability which supports patrolling and Posal Miangas maritime operations. The strategic steps that need to be implemented to realize optimal Posal Miangas facilities by: Adding sea facilities (1 Unit Sea Rider; or 1 Unit Combat Boat), fulfilling Posal Miangas personnel, and procuring electronic observation facilities in the form of coastal radar.

Green building (GB) projects, although being developed and operated for more than two decades, may still be regarded as innovative. To address the socio-environmental challenges of the built environment, GBs need to continuously innovate. A comprehensive account of the innovation frontiers and factors affecting GB project innovation is missing in previous studies. In this study, for an in-depth understanding of what makes these projects innovative and how to create an enabling environment for their innovation, semi-structured interviews with 45 GB experts from six regions were conducted. Innovation in GBs was found to be a function of the GB idea, constituent building technologies, potential performance, and the project development process. Key frontiers where innovation in GB projects is needed include environmental performance, health and well-being, and the resolution of mutually contradicting project aspirations. The study also identified some factors contributing to innovation in GBs, which are primarily related to support from the government, client, and project team; availability of time and budget; scalability of innovative solutions; and nature of the construction industry. A nexus between green certifications, sustainability, and innovation is also explained. The awareness and understanding of industry experts regarding GB project innovation will add to the theory of GB projects and green innovation, and will help stakeholders to create a more enabling environment for innovation.

Hadrian's Wall remains one of the most iconic elements of Roman frontier infrastructure, with considerable symbolic capital in all kinds of contemporary situations and representations. Whether inspiring the fictional ice wall in Game of Thrones or illustrating debates about English–Scottish relationships in Brexit-era Britain, the Wall has a powerful legacy. In more scholarly circles, the Wall sometimes figures in the literature of the emerging field of Border Studies, too, and in this paper I examine some of these representations, as a prelude to discussing what Border Studies offers to Wall studies within Roman archaeology. While the interdisciplinary nature of Border Studies can mean that Hadrian's Wall is misunderstood when taken out of context, this does not mean that the broader insights of Border Studies have no value to Roman archaeologists in better interpreting the Wall and its place in Roman Britain. To the contrary, the combination of innovative theories of frontiers and borderlands with detailed, nuanced understanding of the Wall communities through time has much to offer the archaeology of Britain in the Roman empire. Indeed, this field has the potential to connect frontier studies better with other dimensions of Roman provincial archaeology than has been typical in our discipline over much of the last half-century. [ABSTRACT FROM AUTHOR]

Background: Non-coding RNAs (ncRNA) are a kind of RNA that does not encode protein, which play an important role in Alzheimer’s disease (AD). However, there is a lack of bibliometric analysis and visualization analysis of the research related to AD and ncRNAs. Materials and methods: Literature related to AD and ncRNAs in the last decade were searched through the Web of Science Core Collection (WOSCC). The relevant information from all the searched articles was collected. The bibliometric visualization website, CiteSpace, and VOSviewer were used for visualization analysis of countries/regions, institutions, authors, and keywords. Results: In total, 1,613 kinds of literature were published in the field. Literature in this field were published in 494 journals. The Journal of Alzheimer’s Disease was the most popular journal. China, Louisiana State University System, and Lukiw WJ were the countries/regions, institutions, and authors with the highest scientific productivity, respectively. The research hotspots in this field focused on the role and mechanism of ncRNAs, especially microRNAs, in AD. The level of research was mainly based on basic research, focusing on animal and cellular levels, and related to proteomics. “Circular RNAs,” “regulation of neuroinflammation,” and “tau protein” were the future research directions. Conclusion: Taken together, the field of AD and ncRNAs is developing well. The research hotspots and frontiers in this field can provide a reference for researchers to choose their research direction. [ABSTRACT FROM AUTHOR]

In 2019, Gray & Pape, Inc., conducted data-recovery efforts at the Hodges site (12MG564), a predominately late precontact Oliver phase (AD 1200–1450) site found in the White River valley of Indiana. Investigations of the site have fostered new ideas regarding the emergence of the Oliver phase. Previous models have suggested that the emergence of the Oliver phase was largely due to the migration of Fort Ancient groups into the region. Other models suggested that the region served as a frontier. The concepts of frontier interaction zones and fluid boundaries are presented here as the reasons for the emergence of the Oliver phase from in situ Late Woodland populations. [ABSTRACT FROM AUTHOR]

Research around sport-related concussion (SRC) has made great advances during the twenty-first century. However, few studies have systematically analyzed the published SRC research. A bibliometric analysis was conducted of data from articles from the Web of Science Core Collection database. Descriptive statistics were used to analyze publication trends, most productive countries, institutions, authors, journals, research fields, and references with the highest citation number. VOSviewer software was used to perform network visualization and keywords co-occurrence analysis. CiteSpace software was used to perform reference co-citation analysis. 1) The number of publications and number of citations of research in SRC progressively increased between 2000 and 2021; 2) the United States was the leading country in research in SRC; 3) extensive cooperation among countries, institutions, and investigators was prevalent in SRC research; 4) P. McCrory, M. McCrea, and K.M. Guskiewicz were the 3 most prolific and influential authors; 5) research in SRC involved multidisciplinary perspectives and approaches; 6) research in SRC mainly covered aspects of primary prevention, diagnosis, and management, and the latter two have gained more attention in recent years; and 7) specific questions about "education," "predictors," "youth," "exercise," "reliability," "validity," and "baseline" were the research frontiers of SRC. Attention to research in SRC has rapidly increased in recent years. Our work is a holistic overview that summarizes the hotspots, frontiers, and prospects of SRC, thus providing valuable information and guidance concerning research directions for those who are interested in or are dedicated to SRC research. [ABSTRACT FROM AUTHOR]