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Tool actions are characterized by a transformation (of spatio-temporal and/or force-related characteristics) between movements and their resulting consequences in the environment. This transformation has to be taken into account, when planning and executing movements and its existence may affect performance. In the present study we investigated how angular gain transformations between movement and visual feedback during circling movements affect coordination performance. Participants coordinated the visual feedback (feedback dot) with a continuously circling stimulus (stimulus dot) on a computer screen in order to produce mirror symmetric trajectories of them. The movement angle was multiplied by a gain factor (0.5–2; nine levels) before it was presented on the screen. Thus, the angular gain transformations changed the spatio-temporal relationship between the movement and its feedback in visual space, and resulted in a non-constant mapping of movement to feedback positions. Coordination performance was best with gain = 1. With high gains the feedback dot was in lead of the stimulus dot, with small gains it lagged behind. Anchoring (reduced movement variability) occurred when the two trajectories were close to each other. Awareness of the transformation depended on the deviation of the gain from 1. In conclusion, the size of an angular gain transformation as well as its mere presence influence performance in a situation in which the mapping of movement positions to visual feedback positions is not constant. When designing machines or tools that involve transformations between movements and their external consequences, one should be aware that the mere presence of angular gains may result in performance decrements and that there can be flaws in the representation of the transformation.

One of the prominent pharmacological features of drugs acting at the brain cannabinoid receptor (CB1) is the induction of alterations in motor behavior. Catalepsy, immobility, ataxia, or the impairment of complex behavioral acts are observed after acute administration of either natural and synthetic cannabinoid receptor agonists or the endogenous CB1 ligand anandamide. The dense presence of CB1 receptors in the cerebellum and in the basal ganglia, especially at the outflow nuclei (substantia nigra and the internal segment of the globus pallidus), supports the existence of an endogenous cannabinoid system regulating motor activity. In the basal ganglia, the functionality of the anandamide-CB1 system is poorly understood. Dual effects are often observed after the administration of CB1 ligands in animal models of pharmacological manipulation of basal ganglia transmitter systems, indicating that the activity of the anandamide-CB1 system depends on the ongoing activation of the different elements of the basal ganglia. This finding is in agreement with the proposed activity-dependent release of anandamide from a plasmalemma precursor. Additionally, a potential state-dependent bidirectional coupling of the CB1 receptor to the adenylate cyclase transduction system has also been described. From this perspective, the endogenous cannabinoid system can be proposed as a local regulator of neurotransmission processes within the basal ganglia. This system may serve as a counterregulatory homeostatic mechanism preserving the functional role of basal ganglia circuits in coding the serial order of events that constitute movement.

Repetitive behaviors (such as circling) are one of the defining features of autism. The substantia nigra (SN) is involved in circling. We used unilateral SN pars reticulata (SNR) infusions of the GABA agonist muscimol to induce circling and deoxyglucose autoradiography mapping in adult and postnatal day (PN) 15 male and female rats to determine its substrates. In adults, muscimol infusions in posterior SNR induced a higher circling rate than in anterior SNR, after which males displayed faster circling than females. In contrast, PN15 female rats circled faster than PN15 male rats. Autoradiograms demonstrated age- and sex-specific alterations of deoxyglucose uptake in the SN pars compacta (SNC) associated with highest circling rates. The data suggest that there is a close relationship of the GABAergic SNR and dopaminergic SNC in the induction of circling; there is a topographic organization of the SNR in terms of circling behavior and associated deoxyglucose uptake, which is dependent on age and sex.

A video image analyzing system is presented which measures turning behavior, thigmotactic scanning and locomotion in rats. The system works by analyzing digitized video images obtained by a black/white video camera. Turning behavior is expressed in different diameter classes and as partial or full turns. Thigmotactic scanning is expressed as distance or time locomoted with the left or right side of the body along one of the walls of the testing environment. Locomotion is measured as distance travelled and is expressed in meters. Examples for the application of these behavioral measures are given which include: the measurement of spontaneous or drug-dependent behavioral asymmetries after brain lesion (the unilateral 6-hydroxydopamine model), a unilateral peripheral manipulation (hemivibrissotomy), and the measurement of open-field behavior (spontaneous or drug-induced) in intact animals. Among others, these examples show that the analysis of thigmotactic scanning may provide an alternative behavioral measure,which may be especially useful in the study of functional asymmetries. Deutsche Forschungs gemeinschaft/[Hu 306/6-4]/DFG/Alemania UCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicina UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)

Reindeer (Rangifer tarandus) kept in corrals or otherwise forced to clump typically start milling in response to stressing events. This behaviour is generally considered to have an antipredator effect. An inquiry on herd behaviour, to which 35 Norwegian reindeer husbandry districts responded, showed that 32 experienced that corralled rein¬deer consistently circled leftwards, whereas the remaining three reported consistently rightward circling. Regular monitoring of a reindeer herd in central Norway over a two-year period (1993-94), and experimental studies on a fraction of the same herd, revealed the following traits. Free-ranging reindeer showed no right- or left-turning preference during grazing or browsing, but when the reindeer were driven into corrals or forced to clump in the open they invariably rotated leftwards. The circling of corralled reindeer was triggered at an average group size of 20 to 25 animals, apparently independently of the age and sex of the animals. When they dug craters in the snow to reach food, the reindeer used their left foreleg significantly more often than their right. In 23 out of 35 reindeer, the right hemisphere of the brain was heavier than the left. However, in the sample as a whole, the weights of the left and right hemispheres did not differ significantly. Lateralised behaviour in reindeer is thought to be determined by natural and stress induced asymmetries in brain structure and hormonal activity. In addition, learning is probably important for passing on the behaviour between herd members and generations. Differences in lateralised behaviour between nearby herds are thought to be related primarily to different exposure to stress and learning, whereas genetical and environmental fac¬tors (e.g. diet), age structure and sex ratio are probably more important for explaining differences between distant pop¬ulations.