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53. Additional file 1 of Menopausal hormone therapy, oral contraceptives and risk of chronic low back pain: the HUNT Study

Author

Heuch, Ingrid, Heuch, Ivar, Hagen, Knut, Storheim, Kjersti, and Zwart, John-Anker

Abstract

Additional file 1: Table S1. Descriptive statistics of potential risk factors for LBP at baseline in HUNT2, by follow-up status. Table S2. Associations between use of systemic MHT and prevalence or risk of chronic LBP in cross-sectional and cohort analysis, among nonpregnant women aged 40-69 years, with and without adjustment for HADS. Table S3. Associations between use of systemic MHT and prevalence or risk of chronic LBP in cross-sectional and cohort analysis, among nonpregnant women aged 40-69 years, in broad intervals of age in HUNT2. Table S4. Associations between use of OC and prevalence or risk of chronic LBP in cross-sectional and cohort analysis, among women aged 20-69 years, with and without adjustment for HADS. Table S5. Associations between use of OC and prevalence or risk of chronic LBP in cross-sectional and cohort analysis, among women aged 20-69 years, in intervals of BMI in HUNT2.

Published
2023
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54. Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

Author

Wang, Heming, Lane, Jacqueline M., Jones, Samuel E., Dashti, Hassan S., Ollila, Hanna M., Wood, Andrew R., van Hees, Vincent T., Brumpton, Ben, Winsvold, Bendik S., Kantojärvi, Katri, Palviainen, Teemu, Cade, Brian E., Sofer, Tamar, Song, Yanwei, Patel, Krunal, Anderson, Simon G., Bechtold, David A., Bowden, Jack, Emsley, Richard, Kyle, Simon D., Little, Max A., Loudon, Andrew S., Scheer, Frank A. J. L., Purcell, Shaun M., Richmond, Rebecca C., Spiegelhalder, Kai, Tyrrell, Jessica, Zhu, Xiaofeng, Hublin, Christer, Kaprio, Jaakko A., Kristiansson, Kati, Sulkava, Sonja, Paunio, Tiina, Hveem, Kristian, Nielsen, Jonas B., Willer, Cristen J., Zwart, John-Anker, Strand, Linn B., Frayling, Timothy M., Ray, David, Lawlor, Deborah A., Rutter, Martin K., Weedon, Michael N., Redline, Susan, and Saxena, Richa

Published
2019
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55. Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes.

Author

Vigeland, Maria Dehli, Flåm, Siri Tennebø, Vigeland, Magnus Dehli, Espeland, Ansgar, Zucknick, Manuela, Wigemyr, Monica, Bråten, Lars Christian Haugli, Gjefsen, Elisabeth, Zwart, John-Anker, Storheim, Kjersti, Pedersen, Linda Margareth, Selmer, Kaja, Lie, Benedicte Alexandra, and Gervin, Kristina

Subjects
LUMBAR pain, DNA methylation, GENE expression, EPIGENOMICS, AMOXICILLIN, IMMUNOGLOBULIN genes
Abstract

Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and epigenome analyses in patients (n = 100) receiving amoxicillin treatment or placebo for 100 days in the Antibiotics in Modic Changes (AIM) study. Gene expression and DNA methylation were investigated at a genome-wide level at screening, after 100 days of treatment, and at one-year follow-up. We identified intra-individual longitudinal changes in gene expression and DNA methylation in patients receiving amoxicillin, while few changes were observed in patients receiving placebo. After 100 days of amoxicillin treatment, 28 genes were significantly differentially expressed, including the downregulation of 19 immunoglobulin genes. At one-year follow-up, the expression levels were still not completely restored. The significant changes in DNA methylation (n = 4548 CpGs) were mainly increased methylation levels between 100 days and one-year follow-up. Hence, the effects on gene expression occurred predominantly during treatment, while the effects on DNA methylation occurred after treatment. In conclusion, unrecognized side effects of long-term amoxicillin treatment were revealed, as alterations were observed in both gene expression and DNA methylation that lasted long after the end of treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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56. Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder

Author

Kelsoe, John R., Greenwood, Tiffany A., Nievergelt, Caroline M., McKinney, Rebecca, Shilling, Paul D., Smith, Erin N., Schork, Nicholas J., Bloss, Cinnamon S., Nurnberger, John I., Jr., Edenberg, Howard J., Foroud, Tatiana, Koller, Daniel L., Gershon, Elliot S., Badner, Judith A., Liu, Chunyu, Scheftner, William A., Lawson, William B., Nwulia, Evaristus A., Hipolito, Maria, Potash, James, Coryell, William, Rice, John, Byerley, William, McMahon, Francis J., Berrettini, Wade H., Zandi, Peter P., Mahon, Pamela B., McInnis, Melvin G., Zöllner, Sebastian, Zhang, Peng, Craig, David W., Szelinger, Szabolics, Barrett, Thomas B., Schulze, Thomas G., Wedenoja, Juho, Kaunisto, Mari A., Heikkilä, Kauko, Kaprio, Jaakko, Wessman, Maija, Kallela, Mikko, Färkkilä, Markus, Artto, Ville, Aromaa, Arpo, Eriksson, Johan G., Winsvold, Bendik S., Zwart, John-Anker, Gormley, Padhraig, Palotie, Aarno, Kurth, Tobias, Rose, Lynda M., Buring, Julie E., Ridker, Paul M., Chasman, Daniel I., Bettella, Francesco, Steinberg, Stacy, Stefansson, Hreinn, Stefansson, Kari, McMahon, George, Davey-Smith, George, Malik, Rainer, Freilinger, Tobias, Erich Wichmann, Heinz, Dichgans, Martin, Muller-Myhsok, Bertram, Meitinger, Thomas, de Vries, Boukje, Terwindt, Gisela, Stam, Anine H., Frants, Rune R., Pelzer, Nadine, Weller, Claudia M., Zielman, Ronald, Ferrari, Michel D., van den Maagdenberg, Arn M.J.M., Medland, Sarah E., Montgomery, Grant W., Martin, Nicholas G., Nyholt, Dale R., Todt, Unda, Borck, Guntram, Kubisch, Christian, Quaye, Lydia, Williams, Frances M.K., Cherkas, Lynn, Koiranen, Markku, Hartikainen, Anna-Liisa, Pouta, Anneli, Jarvelin, Marjo-Riitta, Arfan Ikram, M., van den Ende, Joyce, Uitterlinden, Andre G., Hofman, Albert, Amin, Najaf, van Duijn, Cornelia, Lehtimäki, Terho, Ligthart, Lannie, Hottenga, Jouke-Jan, Vink, Jacqueline M., Penninx, Brenda W., Boomsma, Dorret I., Schürks, Markus, Jakobsson, Finnbogi, Schoenen, Jean, Heath, Andrew C., Madden, Pamela A.F., Göbel, Hartmut, Heinze, Axel, Heinze-Kuhn, Katja, Schreiber, Stefan, Anttila, Verneri, Daly, Mark J., Alexander, Michael, Raitakari, Olli, Strachan, David P., Jacobsen, Kaya K., Zayats, Tetyana, Akiskal, Hagop S., Haavik, Jan, Bernt Fasmer, Ole, Johansson, Stefan, and Oedegaard, Ketil J.

Published
2015
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57. Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome

Author

Dhariwal, Achal, primary, Haugli Bråten, Lars Christian, additional, Sturød, Kjersti, additional, Salvadori, Gabriela, additional, Bargheet, Ahmed, additional, Åmdal, Heidi, additional, Junges, Roger, additional, Berild, Dag, additional, Zwart, John-Anker, additional, Storheim, Kjersti, additional, and Petersen, Fernanda Cristina, additional

Published
2022
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59. Amoxicillin Did Not Reduce Modic Change Edema in Patients With Chronic Low Back Pain

Author

Kristoffersen, Per M., primary, Vetti, Nils, additional, Grøvle, Lars, additional, Brox, Jens I., additional, Haugli Bråten, Lars C., additional, Grotle, Margreth, additional, Julsrud Haugen, Anne, additional, Rolfsen, Mads P., additional, Froholdt, Anne, additional, Skouen, Jan S., additional, Lutro, Olav, additional, Marchand, Gunn H., additional, Anke, Audny, additional, Zwart, John-Anker, additional, Storheim, Kjersti, additional, Assmus, Jörg, additional, and Espeland, Ansgar, additional

Published
2022
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61. Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Author

Bjornsdottir, Gyda, Stefánsdóttir, Lilja, Thorleifsson, Gudmar, Sulem, Patrick, Norland, Kristjan, Ferkingstad, Egil, Oddsson, Asmundur, Zink, Florian, Lund, Sigrun H., Nawaz, Muhammad S., Bragi Walters, G., Skuladottir, Astros Th., Gudjonsson, Sigurjon A., Einarsson, Gudmundur, Halldorsson, Gisli H., Bjarnadottir, Valgerdur, Sveinbjornsson, Gardar, Helgadottir, Anna, Styrkársdóttir, Unnur, Gudmundsson, Larus J., Pedersen, Ole B., Hansen, Thomas Folkmann, Werge, Thomas, Banasik, Karina, Troelsen, Anders, Skou, Soren T., Thørner, Lise Wegner, Erikstrup, Christian, Nielsen, Kaspar Rene, Mikkelsen, Susan, Andersen, Steffen, Brunak, Søren, Burgdorf, Kristoffer, Hjalgrim, Henrik, Jemec, Gregor, Jennum, Poul, Johansson, Per Ingemar, Nielsen, Kasper Rene, Nyegaard, Mette, Bruun, Mie Topholm, Pedersen, Ole Birger, Dinh, Khoa Manh, Sørensen, Erik, Ostrowski, Sisse R., Johansson, Pär Ingemar, Gudbjartsson, Daniel F., Stefansson, Hreinn, Þorsteinsdóttir, Unnur, Larsen, Margit Anita Hørup, Didriksen, Maria, Sækmose, Susanne, Zeggini, Eleftheria, Hatzikotoulas, Konstantinos, Southam, Lorraine, Gilly, Arthur, Barysenka, Andrei, van Meurs, Joyce B. J., Boer, Cindy G., Uitterlinden, André G., Jonsson, Helgi, Ingvarsson, Thorvaldur, Esko, Tõnu, Mägi, Reedik, Teder-Laving, Maris, Ikegawa, Shiro, Terao, Chikashi, Takuwa, Hiroshi, Meulenbelt, Ingrid, Coutinho de Almeida, Rodrigo, Kloppenburg, Margreet, Tuerlings, Margo, Slagboom, P. Eline, Nelissen, Rob R. G. H. H., Valdes, Ana M., Mangino, Massimo, Tsezou, Aspasia, Zengini, Eleni, Alexiadis, George, Babis, George C., Cheah, Kathryn S. E., Wu, Tian T., Samartzis, Dino, Cheung, Jason Pui Yin, Sham, Pak Chung, Kraft, Peter, Kang, Jae Hee, Hveem, Kristian, Zwart, John-Anker, Luetge, Almut, Skogholt, Anne Heidi, Johnsen, Marianne B., Thomas, Laurent F., Winsvold, Bendik, Gabrielsen, Maiken E., Lee, Ming Ta Michael, Zhang, Yanfei, Lietman, Steven A., Shivakumar, Manu, Smith, George Davey, Tobias, Jonathan H., Hartley, April, Gaunt, Tom R., Zheng, Jie, Wilkinson, J. Mark, Steinberg, Julia, Morris, Andrew P., Jonsdottir, Ingileif, Bjornsson, Aron, Olafsson, Ingvar H., Ulfarsson, Elfar, Blondal, Josep, Vikingsson, Arnor, Brunak, Soren, Ullum, Henrik, Thorsteinsdottir, Unnur, Thorgeirsson, Thorgeir E., Stefansson, Kari, Consortium, DBDS Genetic, Consortium, GO, and Internal Medicine

Subjects
Science, General Physics and Astronomy, Intervertebral Disc Degeneration, Intervertebral Disc/metabolism, Bone and Bones/metabolism, Bone and Bones, General Biochemistry, Genetics and Molecular Biology, health services administration, Humans, Sodium Sulfate Cotransporter/genetics, Intervertebral Disc, 3' Untranslated Regions, health care economics and organizations, Sodium Sulfate Cotransporter, Symporters/genetics, Multidisciplinary, Symporters, Sulfates, General Chemistry, equipment and supplies, Intervertebral Disc Degeneration/genetics, Intervertebral Disc Displacement/genetics, Sulfates/metabolism, population characteristics, human activities, Intervertebral Disc Displacement, Genome-Wide Association Study
Abstract

Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and intervertebral disc disorder (IDD) (58,854 cases, 922,958 controls). We identify 41 variants at 33 loci. The most significant association (ORIDD = 0.92, P = 1.6 × 10−39; ORdorsalgia = 0.92, P = 7.2 × 10−15) is with a 3’UTR variant (rs1871452-T) in CHST3, encoding a sulfotransferase enzyme expressed in intervertebral discs. The largest effects on IDD are conferred by rare (MAF = 0.07 − 0.32%) loss-of-function (LoF) variants in SLC13A1, encoding a sodium-sulfate co-transporter (LoF burden OR = 1.44, P = 3.1 × 10−11); variants that also associate with reduced serum sulfate. Genes implicated by this study are involved in cartilage and bone biology, as well as neurological and inflammatory processes.

Published
2022

62. Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index

Author

Hartley, April, Sanderson, Eleanor, Granell, Raquel, Paternoster, Lavinia, Zheng, Jie, Smith, George Davey, Southam, Lorraine, Hatzikotoulas, Konstantinos, Boer, Cindy G., Van Meurs, Joyce, Zeggini, Eleftheria, Gregson, Celia L., Tobias, Jon H., Stefánsdóttir, Lilja, Zhang, Yanfei, De Almeida, Rodrigo Coutinho, Wu, Tian T., Teder-Laving, Maris, Skogholt, Anne Heidi, Terao, Chikashi, Zengini, Eleni, Alexiadis, George, Barysenka, Andrei, Bjornsdottir, Gyda, Gabrielsen, Maiken E., Gilly, Arthur, Ingvarsson, Thorvaldur, Johnsen, Marianne B., Jonsson, Helgi, Kloppenburg, Margreet G., Luetge, Almut, Mägi, Reedik, Mangino, Massimo, Nelissen, Rob R.G.H.H., Shivakumar, Manu, Steinberg, Julia, Takuwa, Hiroshi, Thomas, Laurent, Tuerlings, Margo, Babis, George, Cheung, Jason Pui Yin, Samartzis, Dino, Lietman, Steve A., Slagboom, P. Eline, Stefansson, Kari, Uitterlinden, André G., Winsvold, Bendik, Zwart, John Anker, Sham, Pak Chung, Thorleifsson, Gudmar, Gaunt, Tom R., Morris, Andrew P., Valdes, Ana M., Tsezou, Aspasia, Cheah, Kathryn S.E., Ikegawa, Shiro, Hveem, Kristian, Esko, Tõnu, Wilkinson, J. Mark, Meulenbelt, Ingrid, Michael Lee, Ming Ta, Styrkársdóttir, Unnur, and Internal Medicine

Subjects
Oncology, musculoskeletal diseases, medicine.medical_specialty, UK Biobank, Epidemiology, body mass index, Osteoarthritis, Polymorphism, Single Nucleotide, Genetic correlation, Body Mass Index, Mendelian Randomization, Uk Biobank, Bone Mineral Density, Bone Density, Internal medicine, Mendelian randomization, medicine, Humans, Allele, Risk factor, Bone mineral, business.industry, General Medicine, Mendelian Randomization Analysis, Osteoarthritis, Knee, medicine.disease, Causality, Observational study, business, bone mineral density, Body mass index, Genome-Wide Association Study
Abstract

Objectives Observational analyses suggest that high bone mineral density (BMD) is a risk factor for osteoarthritis (OA); it is unclear whether this represents a causal effect or shared aetiology and whether these relationships are body mass index (BMI)-independent. We performed bidirectional Mendelian randomization (MR) to uncover the causal pathways between BMD, BMI and OA. Methods One-sample (1S)MR estimates were generated by two-stage least-squares regression. Unweighted allele scores instrumented each exposure. Two-sample (2S)MR estimates were generated using inverse-variance weighted random-effects meta-analysis. Multivariable MR (MVMR), including BMD and BMI instruments in the same model, determined the BMI-independent causal pathway from BMD to OA. Latent causal variable (LCV) analysis, using weight-adjusted femoral neck (FN)–BMD and hip/knee OA summary statistics, determined whether genetic correlation explained the causal effect of BMD on OA. Results 1SMR provided strong evidence for a causal effect of BMD estimated from heel ultrasound (eBMD) on hip and knee OA {odds ratio [OR]hip = 1.28 [95% confidence interval (CI) = 1.05, 1.57], p = 0.02, ORknee = 1.40 [95% CI = 1.20, 1.63], p = 3 × 10–5, OR per standard deviation [SD] increase}. 2SMR effect sizes were consistent in direction. Results suggested that the causal pathways between eBMD and OA were bidirectional (βhip = 1.10 [95% CI = 0.36, 1.84], p = 0.003, βknee = 4.16 [95% CI = 2.74, 5.57], p = 8 × 10–9, β = SD increase per doubling in risk). MVMR identified a BMI-independent causal pathway between eBMD and hip/knee OA. LCV suggested that genetic correlation (i.e. shared genetic aetiology) did not fully explain the causal effects of BMD on hip/knee OA. Conclusions These results provide evidence for a BMI-independent causal effect of eBMD on OA. Despite evidence of bidirectional effects, the effect of BMD on OA did not appear to be fully explained by shared genetic aetiology, suggesting a direct action of bone on joint deterioration.

Published
2022

63. Killing pain?: a population-based registry study of the use of prescription analgesics, anxiolytics, and hypnotics among all children, adolescents and young adults in Norway from 2004 to 2019

Author

Stangeland, Helle, primary, Handal, Marte, additional, Skurtveit, Svetlana Ondrasova, additional, Aakvaag, Helene Flood, additional, Dyb, Grete, additional, Wentzel-Larsen, Tore, additional, Baumann-Larsen, Monica, additional, Zwart, John Anker, additional, Storheim, Kjersti, additional, and Stensland, Synne Øien, additional

Published
2022
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66. Cluster headache polygenetic risk and known functional variants of CYP3A4 are not associated with treatment response.

Author

Petersen, Anja Sofie, Barloese, Mads, Lund, Nunu, Pedersen, Adam Friis, Søborg, Marie‐Louise Kulas, Chalmer, Mona Ameri, Callesen, Ida, Winsvold, Bendik Slagsvold, Zwart, John‐Anker, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Sellebjerg, Finn, Søndergaard, Helle Bach, Hansen, Malene Bredahl, Jensen, Rigmor Højland, and Hansen, Thomas Folkmann

Subjects
CLUSTER headache, CYTOCHROME P-450 CYP3A, GENOME-wide association studies, SINGLE nucleotide polymorphisms, DISEASE risk factors, GENETIC variation
Abstract

Background and purpose: The response to cluster headache treatments has a high interindividual variation. To date, treatment response has only been assessed by a candidate gene approach and no investigations into metabolic pathways have been performed. Our aim was to investigate the association between the polygenetic risk of cluster headache and treatment response to first‐line cluster headache treatments as well as known functional variants of CYP3A4 and the response to verapamil. Further, it was aimed to replicate previous single nucleotide polymorphisms found to be associated with treatment response in cluster headache and/or migraine. Methods: In, 508 cluster headache patients diagnosed according to the International Classification of Headache Disorders were genotyped and participated in a semi‐structured interview to evaluate treatment response. Polygenetic risk scores were calculated by the effect retrieved from a meta‐analysis of the latest two genome‐wide association studies on cluster headache. Results: Inferior treatment response to oxygen, triptans and verapamil is associated with chronicity of cluster headache were confirmed but no evidence was found that a response could be predicted by a high genetic risk of cluster headache. Likewise, verapamil response was not associated with functional variants of CYP3A4. No support of the genetic variants previously reported to be associated with treatment response to triptans or verapamil was found. Conclusion: The clinically relevant variation in treatment response for cluster headache was not influenced by genetic factors in the present study. [ABSTRACT FROM AUTHOR]

Published
2023
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67. Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas

Author

Eising, Else, Huisman, Sjoerd M. H., Mahfouz, Ahmed, Vijfhuizen, Lisanne S., Anttila, Verneri, Winsvold, Bendik S., Kurth, Tobias, Ikram, M. Arfan, Freilinger, Tobias, Kaprio, Jaakko, Boomsma, Dorret I., van Duijn, Cornelia M., Järvelin, Marjo-Riitta R., Zwart, John-Anker, Quaye, Lydia, Strachan, David P., Kubisch, Christian, Dichgans, Martin, Davey Smith, George, Stefansson, Kari, Palotie, Aarno, Chasman, Daniel I., Ferrari, Michel D., Terwindt, Gisela M., de Vries, Boukje, Nyholt, Dale R., Lelieveldt, Boudewijn P. F., van den Maagdenberg, Arn M. J. M., and Reinders, Marcel J. T.

Published
2016
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82. Low Back Pain With Persistent Radiculopathy; the Clinical Role of Genetic Variants in the Genes SOX5, CCDC26/GSDMC and DCC

Author

Lie, Marie Udnesseter, primary, Pedersen, Linda Margareth, additional, Heuch, Ingrid, additional, Winsvold, Bendik, additional, Gjerstad, Johannes, additional, Hasvik, Eivind, additional, Nygaard, Øystein Petter, additional, Grotle, Margreth, additional, Matre, Dagfinn, additional, Zwart, John-Anker, additional, and Nilsen, Kristian Bernhard, additional

Published
2022
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83. Stroke genetics informs drug discovery and risk prediction across ancestries

Author

Debette, Stéphanie, primary, Mishra, Aniket, additional, Malik, Rainer, additional, Hachiya, Tsuyoshi, additional, Jürgenson, Tuuli, additional, Namba, Shinichi, additional, Koido, Masaru, additional, Grand, Quentin Le, additional, Kamanu, Frederick, additional, Shi, Mingyang, additional, He, Yunye, additional, Georgakis, Marios, additional, Caro, Ilana, additional, Krebs, Kristi, additional, Vaura, Felix, additional, Habib, Naomi, additional, Winsvold, Bendik, additional, Jee, Yon Ho, additional, Thomassen, Jesper Qvist, additional, Abedi, Vida, additional, Cárcel-Márquez, Jara, additional, Lin, Kuang, additional, Nygaard, Marianne, additional, Chauhan, Ganesh, additional, Leonard, Hampton, additional, Yang, Chaojie, additional, Yonova-Doing, Ekaterina, additional, Knol, Maria, additional, Ago, Tetsuro, additional, Amouyel, Philippe, additional, Anderson, Christopher, additional, Armstrong, Nicole, additional, Bakker, Mark, additional, Bartz, Traci, additional, Bis, Joshua, additional, Bordes, Constance, additional, Borte, Sigrid, additional, Cain, Anael, additional, Ridker, Paul, additional, Chen, Zhengming, additional, Chong, Michael, additional, Cole, John, additional, de Cid, Rafael, additional, Endres, Matthias, additional, Ferreira, Leslie, additional, Gasca, Natalie, additional, Gudnason, Vilmundur, additional, Hata, Jun, additional, Havulinna, Aki, additional, Hopewell, Jemma, additional, Hyacinth, Hyacinth, additional, Inouye, Michael, additional, Jacob, Mina, additional, Jeon, Christina , additional, Jern, Christina, additional, Kamouchi, Masahiro, additional, Keene, Keith, additional, Kitazono, Takanari, additional, Kittner, Steven, additional, Konuma, Takahiro, additional, Kumar, Amit, additional, Lacaze, Paul, additional, Launer, Lenore, additional, Lepik, Kaido, additional, Li, Jiang, additional, Li, Liming, additional, Manichaikul, Ani, additional, Markus, Hugh, additional, Marston, Nicholas, additional, Meitinger, Thomas, additional, Mitchell, Braxton, additional, Montellano, Felipe, additional, Morisaki, Takayuki, additional, Mosley, Thomas, additional, Nalls, Mike, additional, Nordestgaard, Børge, additional, O'Donnell, Martin, additional, Okada, Yukinori, additional, Pare, Guillaume, additional, Peters, Annette, additional, Psaty, Bruce, additional, Rich, Stephen, additional, Rosand, Jonathan, additional, Sabatine, Marc, additional, Sacco, Ralph, additional, Saleheen, Danish, additional, Sandset, Else Charlotte, additional, Sargurupremraj, Muralidharan, additional, Sasaki, Makoto, additional, Satizabal, Claudia, additional, Schmidt, Carsten, additional, Shimizu, Atsushi, additional, Smith, Nicholas, additional, Strbian, Daniel, additional, Sutoh, Yoichi, additional, Tanno, Kozo, additional, Tiedt, Steffen, additional, Torres-Aguila, Nuria, additional, Trégouët, David-Alexandre, additional, Trompet, Stella, additional, Tuladhar, Anil, additional, Tybjærg-Hansen, Anne, additional, Vugt, Marion van, additional, Vibo, Riina, additional, Wiggins, Kerri, additional, Woo, Daniel, additional, Xu, Huichun, additional, Yang, Qiong, additional, Lathrop, Mark, additional, Millwood, Iona, additional, Gieger, Christian, additional, Ninomiya, Toshiharu, additional, Grabe, Hans, additional, Jukema, J Wouter, additional, Rissanen, Ina, additional, Seshadri, Sudha, additional, Longstreth, William, additional, Chasman, Daniel, additional, Howson, Joanna, additional, Irvin, Marguerite, additional, Adams, Hieab, additional, Wasssertheil-Smoller, Sylvia, additional, Christensen, Kaare, additional, Ikram, M. Arfan, additional, Rundek, Tatjana, additional, Rotter, Jerome, additional, Riaz, Moeen, additional, Simonsick, Eleanor, additional, Kõrv, Janika, additional, França, Paulo, additional, Fornage, Myriam, additional, Zand, Ramin, additional, Prasad, Kameshwar, additional, Frikke-Schmidt, Ruth, additional, de Leeuw, Frank-Erik, additional, Liman, Thomas, additional, Haeusler, Karl Georg, additional, Ruigrok, Ynte, additional, Heuschmann, Peter, additional, Jung, Keum, additional, Zwart, John-Anker, additional, Niiranen, Teemu, additional, Ruff, Christian, additional, Fernández-Cadenas, Israel, additional, Walters, Robin, additional, Milani, Lili, additional, Kamatani, Yoichiro, additional, and Dichgans, Martin, additional

Published
2022
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90. Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Author

Boer, Cindy G., Hatzikotoulas, Konstantinos, Southam, Lorraine, Stefánsdóttir, Lilja, Zhang, Yanfei, Coutinho de Almeida, Rodrigo, Wu, Tian T., Zheng, Jie, Hartley, April, Teder-Laving, Maris, Skogholt, Anne Heidi, Terao, Chikashi, Zengini, Eleni, Alexiadis, George, Barysenka, Andrei, Bjornsdottir, Gyda, Gabrielsen, Maiken E., Gilly, Arthur, Ingvarsson, Thorvaldur, Johnsen, Marianne B., Jonsson, Helgi, Kloppenburg, Margreet, Luetge, Almut, Lund, Sigrun H., Mägi, Reedik, Mangino, Massimo, Nelissen, Rob R.G.H.H., Shivakumar, Manu, Steinberg, Julia, Takuwa, Hiroshi, Thomas, Laurent F., Tuerlings, Margo, Babis, George C., Cheung, Jason Pui Yin, Kang, Jae Hee, Kraft, Peter, Lietman, Steven A., Samartzis, Dino, Slagboom, P. Eline, Stefansson, Kari, Thorsteinsdottir, Unnur, Tobias, Jonathan H., Uitterlinden, André G., Winsvold, Bendik, Zwart, John-Anker, Davey Smith, George, Sham, Pak Chung, Thorleifsson, Gudmar, Gaunt, Tom R., Morris, Andrew P., Valdes, Ana M., Tsezou, Aspasia, Cheah, Kathryn S.E., Ikegawa, Shiro, Hveem, Kristian, Esko, Tõnu, Wilkinson, J. Mark, Meulenbelt, Ingrid, Lee, Ming Ta Michael, van Meurs, Joyce B.J., Styrkársdóttir, Unnur, and Zeggini, Eleftheria

Published
2021
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92. Genome-wide association study identifies new locus associated with OCD

Author

Strom, Nora I., primary, Yu, Dongmei, additional, Gerring, Zachary F., additional, Halvorsen, Matthew W., additional, Abdellaoui, Abdel, additional, Rodriguez-Fontenla, Cristina, additional, Sealock, Julia M., additional, Bigdeli, Tim, additional, Coleman, Jonathan R. I., additional, Mahjani, Behrang, additional, Thorp, Jackson G., additional, Bey, Katharina, additional, Burton, Christie L., additional, Luykx, Jurjen J., additional, Zai, Gwyneth, additional, Askland, Kathleen D., additional, Barlassina, Cristina, additional, Nissen, Judith Becker, additional, Bellodi, Laura, additional, Bienvenu, O. Joseph, additional, Black, Donald, additional, Bloch, Michael, additional, Boberg, Julia, additional, Bosch, Rosa, additional, Breen, Michael, additional, Brennan, Brian P., additional, Brentani, Helena, additional, Buxbaum, Joseph D., additional, Bybjerg-Grauholm, Jonas, additional, Byrne, Enda M., additional, Camarena, Beatriz, additional, Camarena, Adrian, additional, Cappi, Carolina, additional, Carracedo, Angel, additional, Casas, Miguel, additional, Cavallini, Maria C., additional, Ciullo, Valentina, additional, Cook, Edwin H., additional, Coric, Vladimir, additional, Cullen, Bernadette A., additional, De Schipper, Elles J., additional, Devlin, Bernie, additional, Djurovic, Srdjan, additional, Elias, Jason A., additional, Erdman, Lauren, additional, Estivil, Xavier, additional, Falkenstein, Martha J., additional, Fundin, Bengt T., additional, Gabrielsen, Maiken E., additional, Goes, Fernando S., additional, Grados, Marco A., additional, Grove, Jakob, additional, Guo, Wei, additional, Haavik, Jan, additional, Hagen, Kristen, additional, Havdahl, Alexandra, additional, Hounie, Ana G., additional, Hucks, Donald, additional, Hultman, Christina, additional, Janecka, Magdalena, additional, Jenike, Michael, additional, Karlsson, Elinor K., additional, Klawohn, Julia, additional, Klei, Lambertus, additional, Krasnow, Janice, additional, Krebs, Kristi, additional, Krompinger, Jason, additional, Lanzagorta, Nuria, additional, Macciardi, Fabio, additional, Maher, Brion, additional, McArthur, Evonne, additional, McGregor, Nathaniel, additional, McLaughlin, Nicole C., additional, Meier, Sandra, additional, Miguel, Euripedes C., additional, Mulhern, Maureen, additional, Nestadt, Paul S., additional, Nurmi, Erika L., additional, O’Connell, Kevin S., additional, Osiecki, Lisa, additional, Palviainen, Teemu, additional, Piras, Fabrizio, additional, Piras, Federica, additional, Pulver, Ann E., additional, Rabionet, Raquel, additional, Ramirez, Alfredo, additional, Rauch, Scott, additional, Reichenberg, Abraham, additional, Reichert, Jennifer, additional, Riddle, Mark A., additional, Ripke, Stephan, additional, Sampaio, Aline S., additional, Schiele, Miriam A., additional, Sloofman, Laura G., additional, Smit, Jan, additional, Sobell, Janet L., additional, Artigas, María Soler, additional, Thomas, Laurent F., additional, Vallada, Homero, additional, Veenstra-VanderWeele, Jeremy, additional, Vulink, Nienke N. C. C., additional, Walker, Christopher P., additional, Wang, Ying, additional, Wendland, Jens R., additional, Winsvold, Bendik S., additional, Yao, Yin, additional, Alonso, Pino, additional, Berberich, Götz, additional, Bulik, Cynthia M., additional, Cath, Danielle, additional, Cusi, Daniele, additional, Delorme, Richard, additional, Denys, Damiaan, additional, Eapen, Valsamma, additional, Falkai, Peter, additional, Fernandez, Thomas V., additional, Fyer, Abby J., additional, Geller, Daniel A., additional, Grabe, Hans J., additional, Greenberg, Benjamin D., additional, Hanna, Gregory L., additional, Hickie, Ian M., additional, Hougaard, David M., additional, Kathmann, Norbert, additional, Kennedy, James, additional, Kung-Yee, Liang, additional, Landén, Mikael, additional, Le Hellard, Stéphanie, additional, Leboyer, Marion, additional, Lochner, Christine, additional, McCracken, James T., additional, Medland, Sarah E., additional, Mortensen, Preben B., additional, Neale, Benjamin, additional, Nicolini, Humberto, additional, Nordentoft, Merete, additional, Pato, Michele, additional, Pato, Carlos, additional, Pauls, David L., additional, Pedersen, Nancy L., additional, Piacentini, John, additional, Pittenger, Christopher, additional, Posthuma, Danielle, additional, Ramos-Quiroga, Josep A, additional, Rasmussen, Steven A., additional, Ressler, Kerry J., additional, Richter, Margaret A., additional, Rosário, Maria C., additional, Rosenberg, David R., additional, Ruhrmann, Stephan, additional, Samuels, Jack F., additional, Sandin, Sven, additional, Sandor, Paul, additional, Spalletta, Gianfranco, additional, Stein, Dan J., additional, Stewart, S. Evelyn, additional, Storch, Eric A., additional, Stranger, Barbara E., additional, Turiel, Maurizio, additional, Werge, Thomas, additional, Andreassen, Ole A., additional, Børglum, Anders D., additional, Walitza, Susanne, additional, Hansen, Bjarne K. A., additional, Rück, Christian P., additional, Martin, Nicholas G., additional, Milani, Lili, additional, Mors, Ole, additional, Reichborn-Kjennerud, Ted, additional, Ribasés, Marta, additional, Kvale, Gerd, additional, Mataix-Cols, David, additional, Domschke, Katharina, additional, Grünblatt, Edna, additional, Wagner, Michael, additional, Zwart, John-Anker, additional, Breen, Gerome, additional, Nestadt, Gerald, additional, Metspalu, Andres, additional, Kaprio, Jaakko, additional, Arnold, Paul D., additional, Grice, Dorothy E., additional, Knowles, James A., additional, Ask, Helga, additional, Verweij, Karin J. H., additional, Davis, Lea K., additional, Smit, Dirk J. A., additional, Crowley, James J., additional, Mathews, Carol A., additional, Derks, Eske M., additional, Scharf, Jeremiah M., additional, and Mattheisen, Manuel, additional

Published
2021
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98. Macrophage migration inhibitory factor: a potential biomarker for chronic low back pain in patients with Modic changes

Author

Gjefsen, Elisabeth, primary, Gervin, Kristina, additional, Goll, Guro, additional, Bråten, Lars Christian Haugli, additional, Wigemyr, Monica, additional, Aass, Hans Christian D, additional, Vigeland, Maria Dehli, additional, Schistad, Elina, additional, Pedersen, Linda Margareth, additional, Pripp, Are Hugo, additional, Storheim, Kjersti, additional, Selmer, Kaja Kristine, additional, and Zwart, John Anker, additional

Published
2021
Full Text
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100. Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools

Author

Bahrami, Shahram, Hindley, Guy Frederick Lanyon, Winsvold, Bendik K S, O'Connell, Kevin S, Frei, Oleksandr, Shadrin, Alexey, Cheng, Weiqiu, Bettella, Francesco, Rødevand, Linn, Ødegaard, Ketil Joachim, Fan, Chun C, Pirinen, Matti J, Hautakangas, Heidi M, Martinsen, Amy, Skogholt, Anne Heidi, Brumpton, Ben Michael, Willer, Cristen J, Tronvik, Erling Andreas, Kristoffersen, Espen Saxhaug, Zwart, John Anker Henrik, Nielsen, Jonas Bille, Hagen, Knut, Nilsen, Kristian Bernhard, Hveem, Kristian, Stovner, Lars Jacob, Fritsche, Lars, Thomas, Laurent, Pedersen, Linda Margareth, Gabrielsen, Maiken Elvestad, Johnsen, Marianne Bakke, Lie, Marie, Holmen, Oddgeir Lingaas, Børte, Sigrid, Stensland, Synne, Zhou, Wei, Dale, Anders, Djurovic, Srdjan, Smeland, Olav Bjerkehagen, Andreassen, Ole, University of Helsinki, Department of Mathematics and Statistics, Helsinki Institute for Information Technology, Centre of Excellence in Complex Disease Genetics, Statistical and population genetics, Biostatistics Helsinki, and Institute for Molecular Medicine Finland

Subjects
False discovery rate, Multifactorial Inheritance, BIPOLAR, Migraine Disorders, PATHOPHYSIOLOGY, LOCI, Biology, Genetic correlation, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, HEADACHE, medicine, Humans, migraine, genetics, Genetic Predisposition to Disease, Bipolar disorder, GENOME-WIDE ASSOCIATION, METAANALYSIS, Depression (differential diagnoses), 030304 developmental biology, Genetic association, bipolar disorder, RISK, Genetics, 0303 health sciences, Mental Disorders, 3112 Neurosciences, DEPRESSION, medicine.disease, Phenotype, PREVALENCE, 3. Good health, schizophrenia, Migraine, Schizophrenia, Neurology (clinical), 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are implicated in both. A shared genetic basis to migraine and mental disorders has been suggested but previous studies have reported weak or non-significant genetic correlations and five shared risk loci. Using the largest samples to date and novel statistical tools, we aimed to determine the extent to which migraine’s polygenic architecture overlaps with bipolar disorder, depression and schizophrenia beyond genetic correlation, and to identify shared genetic loci. Summary statistics from genome-wide association studies were acquired from large-scale consortia for migraine (n cases = 59 674; n controls = 316 078), bipolar disorder (n cases = 20 352; n controls = 31 358), depression (n cases = 170 756; n controls = 328 443) and schizophrenia (n cases = 40 675, n controls = 64 643). We applied the bivariate causal mixture model to estimate the number of disorder-influencing variants shared between migraine and each mental disorder, and the conditional/conjunctional false discovery rate method to identify shared loci. Loci were functionally characterized to provide biological insights. Univariate MiXeR analysis revealed that migraine was substantially less polygenic (2.8 K disorder-influencing variants) compared to mental disorders (8100–12 300 disorder-influencing variants). Bivariate analysis estimated that 800 (SD = 300), 2100 (SD = 100) and 2300 (SD = 300) variants were shared between bipolar disorder, depression and schizophrenia, respectively. There was also extensive overlap with intelligence (1800, SD = 300) and educational attainment (2100, SD = 300) but not height (1000, SD = 100). We next identified 14 loci jointly associated with migraine and depression and 36 loci jointly associated with migraine and schizophrenia, with evidence of consistent genetic effects in independent samples. No loci were associated with migraine and bipolar disorder. Functional annotation mapped 37 and 298 genes to migraine and each of depression and schizophrenia, respectively, including several novel putative migraine genes such as L3MBTL2, CACNB2 and SLC9B1. Gene-set analysis identified several putative gene sets enriched with mapped genes including transmembrane transport in migraine and schizophrenia. Most migraine-influencing variants were predicted to influence depression and schizophrenia, although a minority of mental disorder-influencing variants were shared with migraine due to the difference in polygenicity. Similar overlap with other brain-related phenotypes suggests this represents a pool of ‘pleiotropic’ variants that influence vulnerability to diverse brain-related disorders and traits. We also identified specific loci shared between migraine and each of depression and schizophrenia, implicating shared molecular mechanisms and highlighting candidate migraine genes for experimental validation.

Published
2021

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